USRE47219E1 - System for performing remote ischemic conditioning - Google Patents

System for performing remote ischemic conditioning Download PDF

Info

Publication number
USRE47219E1
USRE47219E1 US15/783,628 US201715783628A USRE47219E US RE47219 E1 USRE47219 E1 US RE47219E1 US 201715783628 A US201715783628 A US 201715783628A US RE47219 E USRE47219 E US RE47219E
Authority
US
United States
Prior art keywords
controller
cuff
device
section
attachment section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US15/783,628
Inventor
Rocky Eugene Ganske
Lahav Gil
Adam Shepperdley
Raymond Cracauer
Igal Royblat
Kristopher Thomas Christensen
Rade Gadzic
Christopher Caldarone
Andrew Redington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CellAegis Devices Inc
Original Assignee
CellAegis Devices Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US13/088,243 priority Critical patent/US8764789B2/en
Priority to US14/302,624 priority patent/US9205019B2/en
Application filed by CellAegis Devices Inc filed Critical CellAegis Devices Inc
Priority to US15/783,628 priority patent/USRE47219E1/en
Application granted granted Critical
Publication of USRE47219E1 publication Critical patent/USRE47219E1/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00Pneumatic or hydraulic massage
    • A61H9/005Pneumatic massage
    • A61H9/0078Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • A61H9/0092Cuffs therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/132Tourniquets
    • A61B17/1322Tourniquets comprising a flexible encircling member
    • A61B17/1325Tourniquets comprising a flexible encircling member with means for applying local pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/132Tourniquets
    • A61B17/135Tourniquets inflatable
    • A61B17/1355Automated control means therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • A61B5/022Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A61B5/02233Occluders specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H9/00Pneumatic or hydraulic massage
    • A61H9/005Pneumatic massage
    • A61H9/0078Pneumatic massage with intermittent or alternately inflated bladders or cuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00115Electrical control of surgical instruments with audible or visual output
    • A61B2017/00119Electrical control of surgical instruments with audible or visual output alarm; indicating an abnormal situation
    • A61B2017/00123Electrical control of surgical instruments with audible or visual output alarm; indicating an abnormal situation and automatic shutdown
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00477Coupling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00858Material properties high friction, non-slip
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06Measuring instruments not otherwise provided for
    • A61B2090/064Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A61B2090/065Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01Constructive details
    • A61H2201/0107Constructive details modular
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01Constructive details
    • A61H2201/0173Means for preventing injuries
    • A61H2201/0176By stopping operation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01Constructive details
    • A61H2201/0173Means for preventing injuries
    • A61H2201/0184Means for preventing injuries by raising an alarm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16Physical interface with patient
    • A61H2201/1602Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/165Wearable interfaces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5007Control means thereof computer controlled
    • A61H2201/501Control means thereof computer controlled connected to external computer devices or networks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5023Interfaces to the user
    • A61H2201/5035Several programs selectable
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5023Interfaces to the user
    • A61H2201/5038Interfaces to the user freely programmable by the user
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5023Interfaces to the user
    • A61H2201/5041Interfaces to the user control is restricted to certain individuals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5023Interfaces to the user
    • A61H2201/5043Displays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5058Sensors or detectors
    • A61H2201/5071Pressure sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50Control means thereof
    • A61H2201/5097Control means thereof wireless
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2230/00Measuring physical parameters of the user
    • A61H2230/30Blood pressure
    • A61H2230/305Blood pressure used as a control parameter for the apparatus

Abstract

A system for performing remote ischemic conditioning includes an inflatable cuff configured to encircle a limb of a subject and a controller removably attached to the cuff. The controller includes a pump; a manifold in fluid communication with the pump; a connector in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; a pressure sensor; and a control circuit configured to implement a remote ischemic conditioning treatment protocol.

Description

RELATED APPLICATIONS

This application is a continuation of and claims priority to U.S. patent application Ser. No. 13/088,243, entitled “System For Performing Remote Ischemic Conditioning,” filed Apr. 15, 2011, the entire disclosure of which is incorporated herein by reference.

FIELD

This invention relates generally to systems for performing remote ischemic conditioning, and more particularly, to systems for performing remote ischemic conditioning incorporating a removable controller.

BACKGROUND

Ischemic diseases are significant causes of mortality in industrialized nations. It is well established that tissue damage results from ischemia (insufficient blood flow to a tissue) followed by reperfusion (reflow of blood to the tissue). Ischemia and reperfusion cause disturbance of microcirculation with ensuing tissue damage and organ dysfunction. Organs such as the kidney, heart, liver, pancreas, lung, brain and intestine are known to sustain damage following ischemia and reperfusion.

In ischemic conditioning (IC), a tissue or organ or region of a subject's body is deliberately subjected to brief ischemic episodes, followed by brief reperfusion episodes. IC has been found to render the tissue, organ or region resistant to injury during subsequent ischemic episodes. The phenomenon of ischemic conditioning has been demonstrated in most mammalian tissues. IC is now recognized as one of the most potent innate protective mechanisms against ischemia-reperfusion (I-R) injury.

Remote ischemic conditioning (RIC) refers to the deliberate induction of transient ischemia in a subject at a region remote from at least some of the tissue to be protected. Often, RIC includes inducing transient ischemia in a subject's limb to protect organs remote from the limb, such as the myocardium. Myocardial protection has been demonstrated by a variety of remote stimuli, including renal ischemia, liver ischemia, mesenteric artery ischemia, and skeletal muscle hind limb ischemia.

RIC, in the broadest sense, involves deliberate induction of an ischemic period followed by a reperfusion period. The ischemic period may involve complete cessation of blood flow (blood flow occlusion). Such ischemic periods may be induced by applying super-systolic pressures on a region of the body, such as for example a limb. Alternatively, ischemic periods may also be induced by applying a less than systolic pressure.

RIC may be performed prior to (pre-), during (per-) and/or following (post-) an ischemic injury or other injury which benefits from RIC. RIC has shown benefit in reducing or preventing damage resulting from, myocardial infarction and trauma, inter alia.

SUMMARY

In one aspect, a device for performing RIC includes an inflatable cuff configured to encircle a limb of a subject and a controller removably attached to the cuff. The controller includes a pump; a manifold in fluid communication with the pump; an outlet in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; a pressure sensor; and a control circuit configured to implement a RIC treatment protocol.

In another aspect, a cuff assembly may be adapted to encircle a limb of a subject. The cuff assembly includes an inner layer, an outer layer, and a bladder disposed between the inner layer and the outer layer. The outer layer includes two flexible foam sections spaced apart in a longitudinal direction of the cuff assembly. The outer layer also includes an intermediate section disposed between the two flexible foam sections. The intermediate section may have a greater rigidity than the two flexible foam sections.

In a further aspect, a device includes an inflatable cuff and a controller attachment section. The inflatable cuff may be configured to encircle a limb of a subject. The cuff has an axial direction substantially parallel to an axis of the limb when the cuff is in the fitted state. The controller attachment section may be operatively attached to the cuff by at least one attachment joint oriented substantially parallel to the axial direction of the cuff. The controller attachment section may include a connector adapted for removable attachment of a controller. The controller attachment section may provide fluid communication between the controller and cuff in a location removed from the connector when the controller is in an attached state.

It should be appreciated that all combinations of the foregoing aspects and additional concepts discussed in greater detail below (provided such concepts are not mutually inconsistent) are contemplated as being part of the inventive subject matter disclosed herein.

The foregoing and other aspects, embodiments, and features of the present teachings can be more fully understood from the following description in conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings are not intended to be drawn to scale. In the drawings, each identical or nearly identical component that is illustrated in various figures is represented by a like numeral. For purposes of clarity, not every component may be labeled in every drawing. Various embodiments of the invention will now be described, by way of example, with reference to the accompanying drawings, in which:

FIG. 1 is a schematic perspective view of an assembled system for remote ischemic conditioning with a removable controller;

FIG. 2 is a schematic perspective view of the system for remote ischemic conditioning depicted in FIG. 1 with the controller removed;

FIG. 3 is a cross sectional view of the system for remote ischemic conditioning depicted in FIG. 1 taken along the line 3-3 in FIG. 1;

FIG. 4 is an exploded schematic perspective view of the cuff of the system depicted in FIG. 1;

FIG. 5 is a schematic top perspective view of the controller attachment section of the system depicted in FIG. 1;

FIG. 6 is a schematic bottom perspective view of the controller attachment section of the system depicted in FIG. 1;

FIG. 7 is a schematic bottom perspective view of the controller of the system depicted in FIG. 1;

FIG. 8 is a schematic top perspective view of the controller of the system depicted in FIG. 1;

FIG. 9 is a cross sectional view of the controller and controller attachment section while coupled to the system depicted in FIG. 1;

FIG. 9A is a detailed view of FIG. 9 corresponding to box A of FIG. 9;

FIG. 10 is a schematic perspective view of the controller of the system depicted in FIG. 1 with the cover removed;

FIG. 11 is a schematic perspective view of the controller of the system depicted in FIG. 1 with the cover and PCB removed;

FIG. 12. is a schematic perspective view of a charging cradle to be used with the controller; and

FIG. 13 is a schematic perspective view of the charging cradle of FIG. 12 with an optional wall mount.

DETAILED DESCRIPTION

The illustrative embodiments described herein are not necessarily intended to show all aspects of the invention. Aspects of the invention are not intended to be construed narrowly in view of the illustrative embodiments. It should be appreciated that the various concepts and embodiments introduced above and those discussed in greater detail below may be implemented in any of numerous ways, as the disclosed concepts and embodiments are not limited to any particular manner of implementation. In addition, it should be understood that aspects of the invention may be used alone or in any suitable combination with other aspects of the invention.

In one aspect, a system for performing RIC includes an inflatable cuff, a controller attachment section joined to the cuff, and a controller selectively removable from the controller attachment section. The controller may control the inflation and deflation of the inflatable cuff. Furthermore, the controller may include a control circuit programmed to implement an RIC protocol. In another aspect the cuff may be soft, rigid, and made from thermoformable materials.

Turning now to the figures, several possible embodiments are described in further detail.

FIGS. 1 and 2 illustrate one embodiment of a system 2 for RIC. System 2 may include an inflatable cuff 4, a controller attachment section 6, and a controller 8. In some embodiments, as depicted in FIG. 2, the controller 8 is selectively removable from system 2. The controller attachment section 6 may include an interlocking retaining tab 10 adapted to provide removable attachment of the controller. The controller attachment section may also include a conduit 12 that provides, sealed, fluid communication between the controller 8 and inflatable cuff 6.

In one aspect, cuff 4 is axially rigid while being soft or non-irritating to the skin. In one embodiment, cuff 4 may include an inner layer 16, a layer 18, and a selectively inflatable bladder 20 disposed between layers 16 and 18, as depicted in FIG. 4. Cuff 4 may be adapted to encircle a limb of an individual. Axis 15 represents the approximate center of a circular configuration formed when cuff 4 is wrapped about a patient's limb. An axial direction of cuff 4 corresponds to the approximate direction of axis 15. Cuff 4 has a longitudinal direction extending down the length of cuff 4 which is substantially perpendicular to the above defined axial direction. Cuff 4 may also be intended to be a disposable item for use with removable controller 8. Inner layer 16 typically is positioned adjacent to, and often in contact with, the skin of an individual wearing system 2. Since inner layer 16 may be in contact with skin, the inner layer may be made from a soft and/or non-irritating material. The inner layer 16 may be made from a knit, woven, or felted cloth. The cloth may include either natural or synthetic materials. Possible cloths include brushed polyester, brushed nylon, and/or other suitable materials as would be apparent to one of skill in the art. Alternatively, inner layer 16 may be made from a foam. In some embodiments, inner layer 16 may be further adapted to provide moisture absorption, wicking, and/or breathability to cuff 4.

In some embodiments, cuff 4 may include two sections 22 spaced apart in a longitudinal direction and an intermediate section 24 disposed between the sections 22. Intermediate section 24 may be constructed to have a greater rigidity than sections 22. The increased rigidity of the intermediate section 24 may be created either by an inherent material property difference, a difference in the physical construction (e.g. a thicker section and/or inclusion of reinforcing features), or both. In one embodiment, the intermediate section 24 may include a substantially flat outer surface 25 for attachment to the controller attachment section 6. Intermediate section 24 may also include an inner surface 26 which is curved in the longitudinal direction of the cuff 4. The curved inner surface 26 may be constructed so as to generally conform to the curvature of a limb. In some embodiments, the size and curvature of the cuff 4 may be suited for a variety of sizes and ages of patients ranging from neonates to obese adults. The cuff 4 may also be sized for either attachment to an arm or a leg. The intermediate section 24 may be constructed from thermosetting plastics, thermoforming plastics, and/or foamed materials. Sections 22 and the intermediate section 24 may be integrally formed with one another, or they may be formed separately and subsequently joined using any appropriate method including, but not limited to, a sewn seam, ultrasonic welds, adhesives, rivets, clamping structures, and/or mechanically interlocking features. Section 22 may be formed of a foam material or any other suitably flexible yet strong material.

In one embodiment, cuff 4 may also include a plurality of reinforcing structures 28 substantially aligned in the axial direction of the cuff assembly. Reinforcing structures 28 typically may be formed in outer layer 18 of sections 22. Reinforcing structures 28 provide axial rigidity to the cuff 4. The increased axial rigidity provided by reinforcing structures 28 helps to distribute the pressure applied by cuff 4 in the axial direction to provide a substantially uniform pressure across the axial width of the cuff 4. Reinforcing structures 28 may also help to prevent kinks in cuff 4 when it is placed around the arm or leg of an individual. Reinforcing structures 28 may be spaced apart in a longitudinal direction to permit the cuff 4 to easily bend around an encircled limb while still providing increased axial rigidity. Reinforcing structures 28 may be curved or straight in shape in the axial direction. In some embodiments, the reinforcing structures 28 may be integrally formed with the foam in sections 22 such as by the application of heat and/or pressure (e.g. thermoforming) to selectively melt and/or compress portions of the foam in sections 22. The uncompressed and/or unmelted portions of foam in sections 22 form the raised reinforcing structures 28. Alternatively, reinforcing structures 28 may be separately formed and subsequently joined to sections 22.

Layer 18 may also include a cloth layer 19 applied to an exterior surface. Cloth layer 19 may be formed of a low stretch or non-stretch cloth. The low stretch or non-stretch properties may be an inherent property of the cloth selected. Alternatively, cloth layer 19 may be a made from thermoformable materials and may be laminated to the exterior surface of layer 18. The lamination process may alter the thermoformable fabric to be a low stretch or non-stretch material. In one embodiment, the cloth may be applied to and laminated with layer 18 in a flat layout prior to forming reinforcing structures 28. Reinforcing structures 28 may subsequently be thermoformed to a final desired shape. The resulting sections 22 may be soft and have low stretch or non-stretch properties. Furthermore, sections 22 may be thermoformable enabling subsequent processing steps.

Selectively inflatable bladder 20 may be disposed between inner layer 16 and layer 18. Bladder 20 may have a valve 30 arranged and adapted to provide a fluid inlet to the interior of bladder 20. Valve 30 extends through a hole 32 in the intermediate section 24 of cuff 4. Valve 30 may be placed in sealed fluid communication with a corresponding structure 33 on controller attachment section 6 which may also be in sealed fluid communication with an outlet 48 of controller 8. When connected to outlet 48 of controller 8 through structure 33 of the controller attachment section 6, valve 30 may provide pressurized gas such as air to bladder 20. In some embodiments, bladder 20 may be a component separate from layers 16 and 18. Bladder 20 may be formed such as by bonding two separate sheets of thermoplastic polyurethane together. In other embodiments, bladder 20 may be formed from air impermeable layers incorporated into layers 16 and 18 of cuff 4. Layers of bladder 20 may be bonded together in an air tight manner using any number of methods including adhesives, ultrasonic welding, beads of material around the edges, and/or other appropriate methods as would be apparent to one of skill in the art. Bladder 20 may also be formed as a unitary structure without separate layers.

Layers 16, 18, 19, and bladder 20 of cuff 4 may be held together at their edges in any suitable fashion, such as by a binding material 36 wrapped around the edge of cuff 4 and sewn to cuff 4, as shown in FIG. 4. Alternatively, cuff 4 may be held together using adhesives, rivets, ultrasonic welds, or other appropriate methods as would be apparent to one of skill in the art.

In one aspect, it may be desirable to provide a non-slip interface to prevent cuff 4 from moving on the limb of a subject, since system 2 may be worn for protracted periods of time. To provide a non-slip interface, at least one non-slip structure 34 may be disposed on the face of inner layer 16. The non-slip structure 34 may be printed, glued, sewn, applied as a bead of material using a guided tool, or by hand. The non-slip structure 34 may include, but is not limited to, one or more strips of silicone.

The cuff 4 may also include fasteners to hold the cuff on a limb of a subject and to adjust the circumferential size of the cuff 4 when in the fitted state. Such fasteners include, but are not limited to, hook and loop fasteners, latches, ratchet mechanisms, clasps, snaps, buckles, and other appropriate structures as would be apparent to one of skill in the art. For example, the fastener may be a hook and loop fastener including a plurality of adjacent unconnected hook sections 38a disposed on layer 18 or 19 and loop sections 38b disposed on inner layer 16. Hook sections 38a may extend in the axial direction of the cuff 4. The width of each hook section 38a, with respect to the longitudinal direction of the cuff, may be selected to provide a flexible cuff able to wrap around different sized limbs.

The controller attachment section 6 of FIG. 1 is shown in more detail in FIGS. 3, 5 and 6. In one embodiment, controller attachment section 6 may include an upper surface 40 for supporting controller 8 in the attached state, a lower surface 44, and an upstanding wall 42 surrounding surface 40. A raised portion 43 of upstanding wall 42 may be located adjacent to and block a power inlet 52 of controller 8 in the attached state. By blocking access to power inlet 52 in the attached state, raised portion 43 may prevent use of the device while controller 8 is connected to an external power source. The controller attachment section 6 may also include a connector, such as retaining tab 10, arranged to provide removable attachment of controller 8. In one embodiment, tab 10 is mounted at one end to surface 40 and includes a projecting edge 41 spaced from surface 40 that faces outwardly towards wall 42. Bosses 45 are disposed on wall 42 on the opposite side of section 6 from tab 10. When controller 8 is attached to attachment section 6, the upper portion of tab 10 is pushed inwardly away from wall 42 so that it passes through slot 49 that is disposed between the body of controller 8 and an outer band 51, as shown in FIG. 7. At the same time, bosses 45 extend into recesses 53 of controller 8, as shown in FIG. 8. Tab 10 has sufficient resilience that when snapped into place, this resilience creates an outward bias on tab 10 that causes edge 41 to overlie the upper edge of band 51. To release controller 8, the upper portion of tab 10 is again pushed inwardly against its bias toward controller 8 until edge 41 overlies slot 49 and is clear of band 51 at which time controller 8 may be pulled out of attachment section 6 at the end closest to tab 10.

In one embodiment, lower surface 44 and/or bottom edge 46 of controller attachment section 6 may be disposed on and substantially conform to the shape of an outer surface of cuff 4. In some embodiments, bottom surface 44 and/or bottom edge 46 of the controller attachment section 6 may be disposed on and substantially conform to the shape of outer surface 25 of intermediate section 24 of cuff 4 shown in FIG. 4. As shown in FIG. 3, the controller attachment section 6 may be joined to outer surface 25 of intermediate section 24 of inflatable cuff 4 along lower surface 44 by at least one and typically two attachment joints 14. In one embodiment, the attachment joint(s) 14 may be oriented substantially parallel to axis 15 of the cuff. The attachment joint 14 may be formed using any appropriate method including, but not limited to, a sewn seam, an ultrasonic weld, an adhesive, and/or rivets. When two or more attachment joints 14 are included, the joints 14 may be spaced apart in the longitudinal direction to allow the cuff 4 to bend and conform to the shape of different sized limbs.

As shown in FIGS. 9 and 9A, controller attachment section 6 may provide fluid communication between the controller 8 and bladder 20 of cuff 4 via structure 33. Structure 33 may include a conduit 12 which is provided in a location spaced from retaining tab 10, when the controller 8 is in an attached state. Conduit 12 fluidly couples controller 8 to valve 30 of bladder 20. Conduit 12 may include a female section 12a that is constructed and arranged to mate with an outlet 48 of controller 8 and a male section 12b that is constructed and arranged to mate with valve 30 of bladder 20. Outlet 48 may include a fluid conduit 58. While a male and female connection have been described, the male and female portions could be reversed or even replaced with other comparable fluid connections, such as a tube or the like. A seal, such as O-ring 60, may be disposed on a shoulder 59 located in structure 33. The O-ring 60 may create a gland seal between female section 12a and outlet 48. Alternatively, a compression seal with O-ring 60 may be used. A retaining structure 61 may be included in structure 33 to retain O-ring 60. Retaining structure 61 may be joined to structure 33 using any appropriate method including, but not limited to, press fitting, ultrasonic welding, and/or adhesives.

As shown in FIG. 8, controller 8 has a front cover 50, which may include controls and displays, and a power inlet 52. Guide structures 54 may be included in controller 8 for alignment and/or engagement with a charging mechanism

The internal components of controller 8 are best shown in FIGS. 10 and 11, where front cover 50 of controller 8 has been removed. Controller 8 may include a pump 62 in fluid communication with a manifold 64. Manifold 64 is in fluid communication with relief valve 68 and outlet 48. Controller 8 may also include a printed circuit board (PCB) 66 which may include a control circuit and memory. The controller 8 may also include a pressure sensor associated with the pressurized components of the system and the control circuit. The pressure sensor (not shown) may be incorporated into pump 62 and/or placed in pressure sensing communication with manifold 64. Furthermore, the pressure sensor may communicate with the control circuit of PCB 66. The control circuit may be programmed to implement an RIC treatment protocol. The controller may also determine blood pressure during, or as part of, an RIC treatment protocol. To provide convenient mobile usage of system 2, batteries 70 may be arranged, typically in series, to provide a higher operating voltage. Alternatively, batteries 70 may be in electrical communication with a transformer adapted to provide a higher operating voltage. In one embodiment, the operating voltage may be approximately 5 to 6 VDC. In other embodiments, the operating voltage may be approximately 12 VDC or any other appropriate voltage. As shown in FIG. 11, PCB 66 may be connected to the other controller components through plug connector 72.

The control circuit of PCB 66 may be programmed with certain error conditions which may cause the procedure to be aborted or which may cause an indication of the error to appear on a display or which can be used in other known ways. These error conditions may include, but are not limited to: the cuff is not pressurized within a predefined period, such as 20 seconds, 30 seconds, 40 seconds, 50 seconds, or one minute; there is no communication between pump 62 and PCB 66 upon start up; there is no communication between pump 62 and PCB 66 for more than a predefined period, such as two, three. four, or five seconds; multiple consecutive repumps are needed to maintain cuff pressure; pump 62 continues to run and does not respond to an abort signal after a predefined number of retrys, such as three, four, or five retrys; pressure in cuff 4 is not near zero gage pressure within a predefined period, such as 20 seconds, 30 seconds, 40 seconds, 50 seconds, or one minute after the end of an inflation cycle; pressure in cuff 4 is above a predetermined pressure such as 200, 220, 240 or 260 mmHg for longer than a predefined period, such as 5, 10, 20, or 30 seconds; and the pump 62 CPU does not wake up after a command is sent to it by the control circuit. The error condition may be cleared and/or the system may be reset such as by pressing a stop button 76 on the face of controller 8.

During usage, controller 8 may be attached to controller attachment section 6 to place controller outlet 48 into fluid communication with cuff 4. Pressurized gas may then be pumped through controller outlet 48 to inflate the cuff 4. The cuff pressure may be controlled by selectively opening valve 68 in response to a command from the control circuitry of PCB 66. In some embodiments, valve 68 may include a pressure safety relief feature that opens valve 68 in response to an over pressure event during an RIC treatment. In one embodiment, valve 68 opens when the pressure in cuff 4 exceeds 260 mmHg. Valve 68 may open in response to either an error command from the control circuitry of PCB 66, or the valve 68 may include an automatically actuated mechanical system. Controller 8 may also include a slow continuous relief valve. Such a valve would continuously release gas from inflated bladder 20 at a selected rate lower than the rated flow rate of the pump 62. The slow continuous release of gas from bladder 20 could be used to deflate bladder 20 in case of a mechanism failure.

In some embodiments, the control circuit of PCB 66 may be programmable by a health professional and/or an end user according to a prescribed treatment protocol. Alternatively, the control circuit may only be programmed at the factory and may not be altered afterwards by the end user. The control circuitry may also include non-volatile memory for the logging and storage of treatment history. A health care professional may be able to access this memory to determine the treatment history of a patient and determine compliance with a prescribed treatment regime. In another embodiment, the controller may send this information via wireless, or hard wired, communication to a separate receiver for patient records, monitoring, or call center purposes. In one embodiment, controller 8 may include a start button 74 and stop button 76. In some embodiments, the start and stop buttons 74 and 76 may be incorporated into a single button. Controller 8 may also include a hard wired and/or emergency stop button and/or a quick release valve (not shown). In other embodiments, other controls may be included to allow expanded control of an RIC treatment.

In addition to controls, controller 8 may include displays related to the current cycle, the number of cycles left in a treatment, whether the treatment is completed, error signals, charge of the system, and other relevant information. In one embodiment, controller 8 may include a cycle time display 78. Cycle time display 78 may indicate the remaining portion of the inflation/deflation cycle by using illuminated indicators 78a arranged in a circular pattern corresponding to a full inflation/deflation cycle. Each indicator 78a of cycle time display 78 may correspond to a set fraction of the inflation/deflation cycle. When all of the indicators 78a of cycle time display 78 are illuminated, the inflation/deflation cycle is complete. Alternatively, the indicators 78a of cycle time display 78 may start a cycle fully illuminated and sequentially turn off as the cycle proceeds. When each indicator 78a of cycle time display 78 is dark, the particular inflation/deflation cycle is complete. While a circular display has been disclosed, cycle time display 78 could also be arranged in other linear, or non-linear, shapes corresponding to a full cycle. Controller 8 may also include a current cycle display 80, or a digital numeric display, indicating whether the current cycle is the first, second, third, or other cycle. A procedure complete indicator 82 may be illuminated with a solid color or it may blink when the RIC treatment is complete to indicate the end of the procedure. An error display 84 may indicate when an error has occurred by blinking or being fully illuminated. Alternatively, error display 84 may blink in a preset pattern or display a particular color to indicate which error has occurred. A battery charge indicator 86 may indicate the approximate charge remaining in the batteries 70, and may also signal that that the remaining charge is only sufficient for one cycle by blinking.

The above described system may be used for implementing an RIC treatment. The treatment includes placing cuff 4 on a limb of a user and attaching controller 8 to controller attachment section 6 on cuff 4. A user may then press start button 74 to initiate the treatment. Once started the control circuitry of PCB 66 monitors the pressure sensor and turns pump 62 on to inflate the cuff 4. The pressure is then increased to a desired pressure, such as a blood flow occlusion pressure. In one embodiment, the control circuitry of PCB 66 maintains the cuff pressure between preselected pressure limits such as 200 mmHg to 210 mmHg. In other embodiments, the control circuitry of PCB 66 may first determine a systolic blood pressure. After determining a systolic blood pressure, the control circuitry of PCB 66 may subsequently initiate the RIC treatment protocol with a desired pressure such as a pressure greater than the measured systolic blood pressure. Regardless of the specific pressure used, the pressure may be maintained for a selected ischemic duration. Ischemic durations may last on the order of seconds or minutes. After completing the ischemic duration, the controller may activate valve 68 to deflate cuff 4 and initiate the reperfusion duration. Reperfusion durations generally last for at least a minute, although shorter reperfusion durations may be used. After completion of the reperfusion duration another RIC cycle may be conducted. An RIC treatment may include a single cycle or multiple cycles. In one embodiment, an RIC treatment may include four cycles with ischemic durations of approximately 5 minutes, and reperfusion durations of approximately 5 minutes. At the end of the last cycle the cuff 4 may deflate within 30 seconds and the controller 8 may confirm a near zero gage pressure prior to shutting down.

In some embodiments, controller 8 may be charged using a charging cradle 88, as shown in FIG. 12. Charging cradle 88 may include a power connector 90 and mating guide structures 92. In one embodiment, mating guide structures 92 on the charging cradle mate with guide structures 54 on the controller. Mating guide structures 92 act as alignment features. In other embodiments, mating guide structures 92 may be actuated when controller 8 is inserted into the charging cradle 88 to turn the power on and off to power connector 90. Charging cradle 88 may also include a raised area 94 to prevent insertion of the controller while controller 8 is connected to cuff 4 or a patient. In addition to the above, charging cradle 88 may optionally connect with a wall mount portion 96 as shown in FIG. 13.

While the present teachings have been described in conjunction with various embodiments and examples, it is not intended that the present teachings be limited to such embodiments or examples. On the contrary, the present teachings encompass various alternatives, modifications, and equivalents, as will be appreciated by those of skill in the art. Accordingly, the foregoing description and drawings are by way of example only.

Claims (40)

What is claimed is:
1. A device for remote ischemic conditioning comprising:
an inflatable cuff configured to encircle a limb of a subject;
a controller removably attached to the cuff, wherein the controller comprises:
a manifold configured to provide fluid communication between the controller and the cuff;
an outlet in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; and
a control circuit configured to implement a remote ischemic conditioning treatment protocol; and
a controller attachment section joined to the cuff, the controller attachment section having a bottom surface that substantially conforms to an outer surface of the cuff, wherein the controller is removably attached to the cuff by selective attachment to the controller attachment section disposed on the cuff, the controller attachment section further comprising:
an upper surface for supporting the controller in an attached state;
an upstanding wall surrounding the upper surface;
a tab mounted at one end of the upper surface and including a projecting edge spaced from the upper surface, the projecting edge facing outwardly toward the upstanding wall; and
bosses disposed on the upstanding wall on the opposite side of the controller attachment section from the tab;
wherein the controller further comprises a slot that is disposed between a body of the controller and an outer band, and wherein the device is arranged such that when the controller is attached to the controller attachment section, an upper portion of the tab is pushed inwardly away from the upstanding wall so that the tab passes through the slot, and the bosses extend into corresponding recesses provided in the controller body.
2. The device of claim 1, wherein the controller attachment section further includes a conduit that provides sealed, fluid communication between the controller and inflatable cuff.
3. The device of claim 1, wherein cuff pressure is controllable by selectively opening a valve of the controller in response to a command from control circuitry of the control circuit.
4. The device of claim 3, wherein the controller attachment section provides fluid communication between the controller and a bladder of the cuff via a structure that includes a conduit that has a female section constructed and arranged to mate with the controller outlet and a male section that is constructed and arranged to mate with a valve of the bladder of the cuff.
5. The device of claim 1, wherein:
an axial direction of the cuff is substantially parallel to an axis of the limb when the cuff is in a fitted state;
the controller attachment section is operatively attached to the cuff by at least one attachment joint oriented substantially parallel to the axial direction of the cuff; and
the controller attachment section provides fluid communication between the controller and the cuff.
6. The device of claim 1, wherein the controller comprises a slow continuous relief valve that continually releases gas from the cuff at a flow rate lower than a flow rate of the gas being introduced into the cuff.
7. The device of claim 1, wherein the controller further comprises at least one valve configured to open in response to an overpressure event, or in response to an error command from the control circuit.
8. The device of claim 7, wherein the valve opens in response to a command from the controller when a specified condition is detected.
9. The device of claim 1, wherein the control circuit maintains a cuff pressure between pre-selected pressure limits during an ischemic duration of the remote ischemic conditioning treatment protocol.
10. A device for remote ischemic conditioning comprising:
an inflatable cuff configured to encircle a limb of a subject;
a controller removably attached to the cuff, wherein the controller comprises:
a manifold configured to provide fluid communication between the controller and the cuff;
an outlet in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; and
a control circuit configured to implement a remote ischemic conditioning treatment protocol; and
a controller attachment section joined to the cuff, the controller attachment section having a bottom surface that substantially conforms to an outer surface of the cuff, wherein the controller is removably attached to the cuff by selective attachment to the controller attachment section disposed on the cuff;
wherein cuff pressure is controllable by selectively opening a valve of the controller in response to a command from control circuitry of the control circuit;
wherein the controller attachment section provides fluid communication between the controller and a bladder of the cuff via a structure that includes a conduit that has a female section constructed and arranged to mate with the controller outlet and a male section that is constructed and arranged to mate with a valve of the bladder of the cuff; and
wherein the controller outlet has an outer dimension at an end spaced from the controller, and the female section of the conduit has an upper opening that is configured to receive the end of the controller outlet, a cross-sectional size of the upper opening of the female section being greater than the outer dimension of the controller outlet and greater than an inner dimension of the male section.
11. The device of claim 10, further comprising an O-ring seal disposed within the upper opening of the female section, the O-ring seal surrounding and sealing the controller outlet when disposed within the female section.
12. The device of claim 11, wherein a mouth of the upper opening of the female section includes a retaining structure that has an upper surface that forms an acute angle with respect to a direction of elongation of the controller outlet.
13. A device for remote ischemic conditioning comprising:
an inflatable cuff configured to encircle a limb of a subject;
a controller removably attached to the cuff, wherein the controller comprises:
an outlet in removable fluid communication with the inflatable cuff; and
a control circuit configured to implement a remote ischemic conditioning treatment protocol;
wherein cuff pressure is controllable by selectively opening a valve of the controller in response to a command from control circuitry of the control circuit;
wherein fluid communication between the controller and a bladder of the cuff is provided via a structure that includes a conduit that has a female section constructed and arranged to mate with the controller outlet and a male section that is constructed and arranged to mate with a valve of the bladder of the cuff; and
wherein the controller outlet has an outer dimension at an end spaced from the controller, and the female section of the conduit has an upper opening that is configured to receive the end of the controller outlet, a cross-sectional size of the upper opening of the female section being greater than the outer dimension of the controller outlet.
14. The device of claim 13, wherein the inflatable cuff comprises:
at least two flexible sections spaced apart in a longitudinal direction of the cuff and an intermediate section disposed between the two flexible sections, the intermediate section having a greater rigidity than the two flexible sections; and
a plurality of reinforcing structures disposed on at least one of the two flexible sections and being elongated in an axial direction substantially perpendicular to the longitudinal direction of the cuff, wherein when the cuff is inflated, the reinforcing structures distribute pressure applied by the cuff in the axial direction.
15. The device of claim 14, wherein the plurality of reinforcing structures are spaced apart in a longitudinal direction, and are generally parallel to one another to permit the cuff to bend around an encircled limb while providing increased rigidity in the direction generally perpendicular to the longitudinal direction.
16. The device of claim 14, wherein the reinforcing structures are curved.
17. The device of claim 14, wherein the reinforcing structures are generally linear.
18. The device of claim 14, wherein the reinforcing structures are integrally formed with the flexible sections.
19. The device of claim 18, wherein the reinforcing structures comprise portions of the flexible sections which are uncompressed.
20. The device of claim 14, wherein the reinforcing structures are formed by providing alternating areas of compressed foam and uncompressed foam.
21. The device of claim 14, wherein the reinforcing structures are formed separately from the flexible sections and are attached to at least one of the two flexible sections after formation of the flexible sections.
22. The device of claim 14, wherein the reinforcing structures extend substantially across a width of the cuff.
23. The device of claim 22, wherein the reinforcing structures distribute pressure applied by the cuff across the width of the cuff in the axial direction.
24. The device of claim 14, wherein the reinforcing structures assist in preventing kinks in the cuff assembly.
25. The device of claim 14, further compromising: an outer layer; an inner layer; and an inflatable bladder disposed between the inner layer and the outer layer.
26. The device of claim 25, wherein the reinforcing structures are formed on the outer layer.
27. The device of claim 25, further comprising at least one non-slip structure disposed on an exterior face of the inner layer and configured to face the limb of the subject.
28. The device of claim 27, wherein the non-slip structure comprises a strip formed of silicone.
29. The device of claim 25, wherein the inner layer is formed of a soft, non-irritating material.
30. The device of claim 25, wherein the inner layer is configured to provide moisture absorption, wicking, and/or breathability to the cuff.
31. The device of claim 30, wherein the inner layer comprises a cloth material.
32. The device of claim 31, wherein the cloth material comprises a felt.
33. The device of claim 25, wherein a fluid inlet to the bladder extends from the bladder through the intermediate section of the outer layer.
34. The device of claim 14, further comprising a fastener to couple together ends of the two flexible sections about the limb of the subject.
35. The device of claim 34, wherein the fastener comprises a hook and loop fastener.
36. The device of claim 14, wherein the intermediate section comprises:
a substantially planar upper surface;
an attachment device configured to removably attach the controller to the upper surface; and
the conduit.
37. The device of claim 36, wherein the intermediate section comprises a curved inner surface extending in the longitudinal direction of the cuff.
38. The device of claim 14, further comprising a controller attachment section disposed on the intermediate section, the controller attachment section being configured to permit removable attachment of the controller.
39. The device of claim 38, wherein the controller attachment section is joined to the intermediate section by two attachment joints that are aligned in a direction generally perpendicular to the longitudinal direction of the cuff.
40. A device for remote ischemic conditioning comprising:
an inflatable cuff configured to encircle a limb of a subject;
a controller removably attached to the cuff; and
a controller attachment section joined to the cuff, the controller attachment section having a bottom surface that substantially conforms to an outer surface of the cuff, wherein the controller is removably attached to the cuff by selective attachment to the controller attachment section disposed on the cuff, the controller attachment section further comprising:
an upper surface for supporting the controller in an attached state; an upstanding wall surrounding the upper surface; and
a tab mounted at one end of the upper surface and including a projecting edge spaced from the upper surface, the projecting edge facing outwardly toward the upstanding wall;
wherein the controller further comprises a slot that is disposed between a body of the controller and an outer band, and wherein the device is arranged such that when the controller is attached to the controller attachment section, an upper portion of the tab is pushed inwardly away from the outstanding wall so that the tab passes through the slot.
US15/783,628 2011-04-15 2017-10-13 System for performing remote ischemic conditioning Active USRE47219E1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/088,243 US8764789B2 (en) 2011-04-15 2011-04-15 System for performing remote ischemic conditioning
US14/302,624 US9205019B2 (en) 2011-04-15 2014-06-12 System for performing remote ischemic conditioning
US15/783,628 USRE47219E1 (en) 2011-04-15 2017-10-13 System for performing remote ischemic conditioning

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15/783,628 USRE47219E1 (en) 2011-04-15 2017-10-13 System for performing remote ischemic conditioning

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US14/302,624 Reissue US9205019B2 (en) 2011-04-15 2014-06-12 System for performing remote ischemic conditioning

Publications (1)

Publication Number Publication Date
USRE47219E1 true USRE47219E1 (en) 2019-02-05

Family

ID=46022677

Family Applications (5)

Application Number Title Priority Date Filing Date
US13/088,243 Active 2032-02-16 US8764789B2 (en) 2011-04-15 2011-04-15 System for performing remote ischemic conditioning
US29/429,677 Active USD709197S1 (en) 2011-04-15 2012-08-15 Combined controller and cuff for remote ischemic conditioning
US29/429,684 Active USD709048S1 (en) 2011-04-15 2012-08-15 Controller for remote ischemic conditioning
US14/302,624 Active US9205019B2 (en) 2011-04-15 2014-06-12 System for performing remote ischemic conditioning
US15/783,628 Active USRE47219E1 (en) 2011-04-15 2017-10-13 System for performing remote ischemic conditioning

Family Applications Before (4)

Application Number Title Priority Date Filing Date
US13/088,243 Active 2032-02-16 US8764789B2 (en) 2011-04-15 2011-04-15 System for performing remote ischemic conditioning
US29/429,677 Active USD709197S1 (en) 2011-04-15 2012-08-15 Combined controller and cuff for remote ischemic conditioning
US29/429,684 Active USD709048S1 (en) 2011-04-15 2012-08-15 Controller for remote ischemic conditioning
US14/302,624 Active US9205019B2 (en) 2011-04-15 2014-06-12 System for performing remote ischemic conditioning

Country Status (7)

Country Link
US (5) US8764789B2 (en)
EP (1) EP2696781A2 (en)
CN (2) CN106420300A (en)
AU (1) AU2012242724B2 (en)
CA (1) CA2870434A1 (en)
TW (2) TWI612956B (en)
WO (1) WO2012142360A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7717855B2 (en) 2006-12-06 2010-05-18 The Hospital For Sick Children System for performing remote ischemic preconditioning
EP2429477B1 (en) * 2009-05-13 2013-07-10 The Hospital For Sick Children Performance enhancement
US8974491B2 (en) 2009-06-23 2015-03-10 Infarct Reduction Technologies Inc. Methods for adaptive limb occlusion
US9801780B2 (en) 2009-06-23 2017-10-31 Lifecuff Technologies Inc. Methods and devices for remote ischemic conditioning via partial limb occlusion
EP2448474B1 (en) 2009-06-23 2019-09-18 Boris Leschinsky Devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
JP2018508314A (en) * 2015-03-18 2018-03-29 ライフカフ テクノロジーズ インコーポレイテッド Method and apparatus for remote ischemia conditioning via partial limb occlusion
AU2011210508B2 (en) * 2010-02-01 2015-01-29 The Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
US8911469B2 (en) * 2010-03-25 2014-12-16 Neocardium, Limited Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
EP2552331A4 (en) 2010-03-31 2015-10-21 Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
RU2012147442A (en) 2010-04-08 2014-05-20 Дзе Хоспитал Фор Сик Чилдрен Application of remote ischemic conditioning in traumatic damage
US8764789B2 (en) 2011-04-15 2014-07-01 CellAegis Devices Inc. System for performing remote ischemic conditioning
GB201112933D0 (en) 2011-07-27 2011-09-14 Olberon Ltd Improvements relating to needle insertion or cannulation
USD708338S1 (en) 2012-08-15 2014-07-01 CellAegis Devices Inc. Cuff for remote ischemic conditioning
WO2014075627A1 (en) * 2012-11-16 2014-05-22 上海微创医疗器械(集团)有限公司 Radial artery hemostat and method for operating radial artery hemostat
WO2014081970A1 (en) 2012-11-21 2014-05-30 Medical Ingenuities, LLC Radial compression hemostasis band with doppler confirming vascular patency
AU2013203746B2 (en) 2013-03-15 2015-05-07 Cellaegis Devices, Inc. Gas Powered System for Performing Remote Ischemic Conditioning
US10272241B2 (en) 2013-03-15 2019-04-30 The Hospital For Sick Children Methods for modulating autophagy using remote ischemic conditioning
WO2014199239A2 (en) * 2013-03-15 2014-12-18 The Hospital For Sick Children Methods relating to the use of remote ischemic conditioning
CA2904504A1 (en) 2013-03-15 2014-09-18 The Hospital For Sick Children Treatment of erectile dysfunction using remote ischemic conditioning
US10136900B2 (en) * 2013-05-26 2018-11-27 M.A.S. Med Global Ltd Pneumatic tourniquet
US20150057585A1 (en) * 2013-08-20 2015-02-26 Covidien Lp Compression device having compliance tracking
USD738355S1 (en) * 2013-09-06 2015-09-08 Dometic Sweden Ab Control
WO2015070997A1 (en) * 2013-11-18 2015-05-21 Olberon Medical Innovation Sas Tourniquet
US20170273695A1 (en) * 2014-08-22 2017-09-28 CellAegis Devices Inc. Medical apparatus incorporating a system for performing remote ischemic conditioning
KR20180030601A (en) * 2015-07-08 2018-03-23 셀에이지스 디바이시스 인크. A configurable system for performing remote ischemia control (RIC) on a subject
US10166166B1 (en) * 2015-08-11 2019-01-01 Trevor James Theriot Apparatus for applying periodic pressure to the limb of a patient and method of use
TWM547950U (en) * 2016-05-31 2017-09-01 Nano-Second Technology Co Ltd Wearable blood pressure measuring device not having the pressure pump
CN105974773A (en) * 2016-07-18 2016-09-28 钦州富仕通科技有限公司 Smart watch capable of detecting blood pressure
CN108354644A (en) * 2016-12-28 2018-08-03 黄河科技学院 The postoperative positioning pressurization bundling device of neck
WO2018144963A1 (en) * 2017-02-06 2018-08-09 Gnotrix, Llc Apparatus and methods of sensing a patient condition, such as anatomy position, and of controlling patient applications
US20190209422A1 (en) * 2017-08-07 2019-07-11 Bhavya Ramesh Shah Device, systems, and methods for prevention of deep vein thrombosis
WO2019177569A1 (en) * 2018-03-12 2019-09-19 Zimmer Biomet CMF and Thoracic, LLC End effector coupler for surgical arm

Citations (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3552383A (en) 1969-01-08 1971-01-05 Ibm Method and system for estimation of arterial pressure
GB1323365A (en) 1969-11-14 1973-07-11 Minnesota Mining & Mfg Disposable blood pressure cuff
US4106002A (en) 1976-12-06 1978-08-08 Hogue Jr Robert J Tourniquet pressure monitor
US4206764A (en) 1976-12-08 1980-06-10 Weisman & Allen Method and apparatus for analyzing cardiovascular systems
US4294261A (en) 1976-06-01 1981-10-13 The United States Of America As Represented By The United States National Aeronautics And Space Administration Logic-controlled occlusive cuff system
US4321929A (en) 1979-10-12 1982-03-30 Lemelson Jerome H Tourniquet
WO1983000995A1 (en) 1981-09-28 1983-03-31 Clark, Nancy, G. Pressure-responsive tourniquet
US4629433A (en) 1982-09-29 1986-12-16 Magid Sidney H Inflatable articles and method of making same
US4664651A (en) 1985-03-01 1987-05-12 The Procter & Gamble Company Subatmospheric method and apparatus for expanding blood vessels to facilitate puncture with a cannula
US4690151A (en) 1984-11-22 1987-09-01 Omron Tateisi Electronics Co. Blood pressure measuring apparatus
JPH021221A (en) 1988-01-27 1990-01-05 Terumo Corp Cuff for measuring blood pressure and blood pressure measuring device having the same cuff
US4967758A (en) 1988-12-08 1990-11-06 Prospect Holdings, Inc. Disposable cover/liner for blood pressure measuring devices
WO1991018571A1 (en) 1990-06-01 1991-12-12 Richard Crangle Disposable multi-use pressurized bandage system
US5072736A (en) 1990-01-19 1991-12-17 Nihon Kohden Corporation Non-invasive automatic blood pressure measuring apparatus
US5135003A (en) 1987-08-11 1992-08-04 Terumo Kabushiki Kaisha Automatic sphygmomanometer
US5201758A (en) 1992-01-07 1993-04-13 Boehringer Mannheim Corporation Disposable tourniquet cuff
US5267565A (en) 1988-02-18 1993-12-07 Beard Jonathan D Method and apparatus for determining the patency of a blood vessel
JPH0751276A (en) 1993-05-27 1995-02-28 Heinrich Ulrich Apparatus for inducing bloodlessness at extremities of patient
US5571075A (en) 1995-04-28 1996-11-05 Bullard; Horace Method for exercise and simultaneous movement of blood by external pressure
US5634467A (en) 1993-11-08 1997-06-03 Robin Medical Technologies Method and apparatus for assessing cardiovascular performance
US5643315A (en) 1994-09-22 1997-07-01 Daneshvar; Yousef Device for wound therapy and prevention of bleeding
US5651369A (en) 1992-01-13 1997-07-29 Tomita; Mitsuei Apparatus for detecting and displaying blood circulatory information
US5687732A (en) 1994-10-07 1997-11-18 Omron Corporation Blood pressure monitor
WO1998030144A1 (en) 1997-01-08 1998-07-16 Biosense Inc. Monitoring of myocardial revascularization
US5830198A (en) * 1994-10-11 1998-11-03 Stryker Corporation Blood conservation system
US5970548A (en) 1995-02-14 1999-10-26 Welch; Robert Dudley Pleated sac for patient support mattress
EP0960598A1 (en) 1998-05-28 1999-12-01 Microlife Systems AG A method and a device for noninvasive measurement of the blood pressure and for detection of arrhythmia
EP1016379A1 (en) 1998-12-31 2000-07-05 Depuy Orthopaedics, Inc. Gel tourniquet cuff
WO2000057776A1 (en) 1999-03-29 2000-10-05 Vasocor, Inc. Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
US6210423B1 (en) 1998-01-29 2001-04-03 Sinil Kim Bone marrow shielding apparatus and method of bone marrow-shielded cancer chemotherapy
US6245023B1 (en) 1999-08-19 2001-06-12 Critikon Company, Llc Conical blood pressure cuff with rectangular bladder
US6251080B1 (en) * 1999-05-13 2001-06-26 Del Mar Medical Systems, Llc Self contained ambulatory blood pressure cincture
US6344025B1 (en) * 1999-02-19 2002-02-05 Omron Corporation Blood pressure monitor
JP2002156773A (en) 2000-09-08 2002-05-31 Ricoh Co Ltd Electrophotographic photoreceptor, method for forming image by using the same, image forming device, process cartridge for the image forming device
EP1249218A2 (en) 2001-04-11 2002-10-16 Colin Corporation Venous thromboembolism preventing apparatus
US6485429B2 (en) 1998-05-28 2002-11-26 Microlife Intellectual Property Gmbh Method and a device for non-invasive measurement of the blood pressure and for detection of arrhythmia
US20030013974A1 (en) 1998-08-07 2003-01-16 Ananth Natarajan Implantable myocardial ischemia detection, indication and action technology
US6550482B1 (en) 2000-04-21 2003-04-22 Vascular Control Systems, Inc. Methods for non-permanent occlusion of a uterine artery
US20030176795A1 (en) 2000-06-02 2003-09-18 Harris Thomas John Blood pressure measurement apparatus and method
US6626840B2 (en) 2000-06-12 2003-09-30 Rutgers, The State University Of New Jersey Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph
US20030216651A1 (en) 2003-03-28 2003-11-20 Applied Cardiac Systems, Inc. System and method for generating external counterpulsation reports
US20030233118A1 (en) 2002-06-13 2003-12-18 Hui John C. K. Method for treating congestive heart failure using external counterpulsation
US20040044290A1 (en) 2001-09-21 2004-03-04 Ward Kevin R Methods for monitoring and optimizing central venous pressure and intravascular volume
US6702720B2 (en) 2001-04-24 2004-03-09 Lifewaves International, Inc. Systems and methods for breathing exercise regimens to promote ischemic preconditioning
US20040064076A1 (en) 2002-09-27 2004-04-01 Jagadish Bilgi External chest therapy blanket for infants
US6719704B2 (en) 2002-05-14 2004-04-13 Colin Corporation Vascular endothelial cell function evaluating apparatus
US20040102818A1 (en) 2002-11-26 2004-05-27 Hakky Said I. Method and system for controlling blood pressure
US20040241634A1 (en) 2003-06-02 2004-12-02 Organ Recovery Systems Method and apparatus for pressure control for maintaining viability of organs
US20040255956A1 (en) 2001-12-21 2004-12-23 Jakob Vinten-Johansen Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
US20050004476A1 (en) 2003-05-28 2005-01-06 Saeed Payvar Method and apparatus for detecting ischemia
WO2005011503A1 (en) 2003-08-05 2005-02-10 The University Of Queensland Apparatus and method for early detection of cardiovascular disease using vascular imaging
US20050070405A1 (en) 2001-10-02 2005-03-31 Norbert Egger Fitness device
WO2005051250A1 (en) 2003-11-30 2005-06-09 Flowmedic Limited A method and apparatus for enhancement of circulation within cast incased body part
RU2253429C1 (en) 2003-12-02 2005-06-10 Государственное образовательное учреждение высшего профессионального образования Московская медицинская академия им. И.М. Сеченова МЗ РФ Method and pneumostocking device for treating obliterating diseases of limb arteries
US6905456B1 (en) 1998-06-26 2005-06-14 B.M.R.A. Corporation B.V. Intermittent compression device
US20050159640A1 (en) 2001-04-24 2005-07-21 Coaxia, Inc. Cerebral perfusion augmentation
US20050171444A1 (en) 2003-12-08 2005-08-04 Nihon Kohden Corporation Vital sign telemeter
US20050177078A1 (en) 2003-10-07 2005-08-11 Loeb Marvin P. External counter pulsation treatment
WO2005077265A1 (en) 2004-02-18 2005-08-25 Miklos Illyes Apparatus and method for measuring hemodynamic parameters
US6962599B2 (en) 2000-11-10 2005-11-08 Vasomedical, Inc. High efficiency external counterpulsation apparatus and method for controlling same
US7004907B2 (en) 2004-04-07 2006-02-28 Triage Wireless, Inc. Blood-pressure monitoring device featuring a calibration-based analysis
US20060052714A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
US20060052713A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
WO2006024871A1 (en) 2004-09-03 2006-03-09 King's College London Methods and apparatus for the measurement of blood pressure
US20060052712A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
US20060058717A1 (en) 2004-09-14 2006-03-16 Hui John C K External counterpulsation device having a curvilinear bed
WO2006030441A2 (en) 2004-09-15 2006-03-23 Itamar Medical Ltd. Measuring blood flow and venous capacitance
US7018335B2 (en) 2003-03-03 2006-03-28 Omron Healthcare Co., Ltd. Blood pressure monitor and cardiovascular disease risk analyzing program
US20060100639A1 (en) 2004-11-05 2006-05-11 G&L Consulting, Llc System and method for the treatment of reperfusion injury
US7048702B2 (en) 2002-06-13 2006-05-23 Vasomedical, Inc. External counterpulsation and method for minimizing end diastolic pressure
WO2006061825A2 (en) 2004-12-07 2006-06-15 Exerflow Medical Ltd External counterpulsation device and method
US20060142663A1 (en) 2004-12-10 2006-06-29 Omron Healthcare Co., Ltd. Electronic blood pressure monitor and blood pressure measuring system
US7111346B2 (en) 2002-05-15 2006-09-26 Non-Invasive Monitoring Systems, Inc. Reciprocating movement platform for the external addition of pulses of the fluid channels of a subject
US20070005106A1 (en) 2005-06-30 2007-01-04 Adducci James P Systems and methods to facilitate muscular benefit using vascular occlusion
US7166077B2 (en) 2004-02-03 2007-01-23 Pharma-Smart, Llc Cuff for measurement of blood pressure
US20070135836A1 (en) 2005-12-14 2007-06-14 Mcewen James A Low-cost disposable tourniquet cuff
US20070150005A1 (en) 2005-12-23 2007-06-28 Sih Haris J Method and apparatus for tissue protection against ischemia using remote conditioning
WO2007085816A1 (en) 2006-01-24 2007-08-02 Bristol-Myers Squibb Company A proximity detection apparatus
WO2007085828A1 (en) 2006-01-24 2007-08-02 Bristol-Myers Squibb Company Control unit assembly
US20070197943A1 (en) 2003-07-18 2007-08-23 Pneu Medex Inc. Fluid operated actuators and pneumatic unloading orthoses
US20080077176A1 (en) 2006-09-21 2008-03-27 Tyco Healthcare Group Lp Safety connector assembly
US7374540B2 (en) 2001-04-05 2008-05-20 Itamar Medical Ltd. Non-invasive probe for detecting medical conditions
US20080139949A1 (en) 2006-12-06 2008-06-12 The Hospital For Sick Children System for performing remote ischemic preconditioning
US7390303B2 (en) 2003-09-30 2008-06-24 Ehud Dafni Assessment of vascular dilatation
US7404221B2 (en) 2003-08-04 2008-07-29 Non-Invasive Monitoring Systems, Inc. Reciprocating movement platform for the external addition of pulses to the fluid channels of a subject
CN201098315Y (en) 2007-11-01 2008-08-13 吉训明;罗玉敏;陈 俊;党 莎;赵士勇 Cerebrovascular and cardiovascular health care therapeutic instrument
US20080222769A1 (en) 2007-03-15 2008-09-18 Hillary Natonson Garment-integrated proprioceptive feedback system
US7427268B2 (en) 2004-02-03 2008-09-23 Pharma-Smart, Llc Ring-shaped cuff for measurement of blood pressure
WO2008148062A1 (en) 2007-05-23 2008-12-04 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
CN101317805A (en) 2007-11-01 2008-12-10 吉训明;罗玉敏;党 莎;赵士勇;陈 俊 Cerebrovascular and cardiovascular health care therapeutic instrument
US7485131B2 (en) 1999-03-29 2009-02-03 Stryker Corporation System and method for controlling pressure in a surgical tourniquet
US20090036785A1 (en) 2006-02-01 2009-02-05 Per Danielsson Blood pressure monitor
WO2009049103A2 (en) 2007-10-09 2009-04-16 Sleep Improvement Center P.C. Blood clot prevention device
US20090124912A1 (en) 2007-11-09 2009-05-14 Western Clinical Engineering Ltd. Tourniquet Apparatus for Measuring Limb Occlusion Pressure
US20090137884A1 (en) 2007-11-25 2009-05-28 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
CN201316381Y (en) 2008-11-11 2009-09-30 首都医科大学宣武医院 Low oxygen saturation human body protecting training instrument
US20090287069A1 (en) 2007-11-25 2009-11-19 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US20090318818A1 (en) 2008-06-20 2009-12-24 Welch Allyn, Inc. Blood pressure monitoring system
US20090324748A1 (en) 2006-07-25 2009-12-31 Hibernation Therapeutics Limited Trauma therapy
US7689286B2 (en) 2006-05-02 2010-03-30 Cardiac Pacemakers, Inc. Myocardium conditioning using myocardial and parasympathetic stimulation
EP2168553A1 (en) 2008-09-30 2010-03-31 Tyco Healthcare Group LP Tubeless Compression Device
US20100081941A1 (en) 2006-03-22 2010-04-01 Endothelix, Inc. Cardiovascular health station methods and apparatus
US20100105993A1 (en) 2007-05-23 2010-04-29 Ic Therapeutics, Inc. Methods and apparatus for noninvasive ischemic conditioning
US20100185220A1 (en) 2007-05-23 2010-07-22 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
US20100186752A1 (en) 2009-01-28 2010-07-29 Sandy Rixson Disposable cuff liner for use with a blood pressure cuff
US20100292619A1 (en) 2009-05-13 2010-11-18 The Hospital For Sick Children Performance enhancement
US20100324429A1 (en) * 2009-06-23 2010-12-23 Boris Leschinsky Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
US20100322467A1 (en) 2004-07-02 2010-12-23 Reed Alastair M Steganographic Encoding and Decoding
US20100328142A1 (en) 2008-03-20 2010-12-30 The Curators Of The University Of Missouri Microwave and millimeter wave resonant sensor having perpendicular feed, and imaging system
US20100326442A1 (en) 2009-06-26 2010-12-30 Hamilton Robert M Resuscitation/respiration system
EP2301496A1 (en) 2009-09-29 2011-03-30 Tyco Healthcare Group LP Pneumatic compression garment with noise attenuating means
US20110152650A1 (en) 2009-12-21 2011-06-23 General Electric Company Adaptive pump control during non-invasive blood pressure measurement
US20110190807A1 (en) 2010-02-01 2011-08-04 The Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
USRE42754E1 (en) * 2001-12-19 2011-09-27 Welch Allyn, Inc. Blood pressure measuring apparatus
US20110238107A1 (en) 2010-03-25 2011-09-29 Fazal Raheman Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
US20110240043A1 (en) 2010-03-31 2011-10-06 The Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
US20110251635A1 (en) 2010-04-08 2011-10-13 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2012024342A1 (en) 2010-08-16 2012-02-23 Breathe Technologies, Inc. Methods, systems and devices using lox to provide ventilatory support
US8123694B2 (en) * 2008-07-18 2012-02-28 Welch Allyn, Inc. Electro pneumatic interface for blood pressure system
US20130317581A1 (en) 2010-12-30 2013-11-28 The Hospital For Sick Children Methods and devices relating to non-invasive electrical nerve stimulation
US20140024986A1 (en) 2011-03-31 2014-01-23 Terumo Kabushiki Kaisha Limb compression device and control method
US8672854B2 (en) * 2009-05-20 2014-03-18 Sotera Wireless, Inc. System for calibrating a PTT-based blood pressure measurement using arm height
US8764789B2 (en) * 2011-04-15 2014-07-01 CellAegis Devices Inc. System for performing remote ischemic conditioning
US8783499B2 (en) * 2006-11-16 2014-07-22 Sangenic International Limited Waste storage device
US9439574B2 (en) * 2011-02-18 2016-09-13 Sotera Wireless, Inc. Modular wrist-worn processor for patient monitoring
US9492094B2 (en) * 2009-07-31 2016-11-15 Omron Healthcare Co., Ltd. Blood pressure monitor
US9743744B2 (en) * 2010-01-28 2017-08-29 Koniklijike Philips N.V. Module retainer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0751276Y2 (en) 1990-02-17 1995-11-22 大建工業株式会社 Roofing materials cutting machine
US5209718A (en) * 1991-10-28 1993-05-11 Mcdaniel William R Pressure applying bandage or drsssing for superficial wounds
DE69427716D1 (en) * 1993-03-10 2001-08-23 Nichiban Kk Adhesive dressing for control of bleeding
USD358216S (en) * 1993-09-16 1995-05-09 The Kendall Company Sleeve for applying compressive pressure to the leg
CN2225870Y (en) * 1995-06-13 1996-05-01 谢济良 Medical air-bag type dilator
USD462450S1 (en) * 2000-11-10 2002-09-03 Vincent E Robinette Electro magnetic stimulation belt control
EP1765253A4 (en) * 2004-06-09 2009-08-19 Flowmedic Ltd A portable self-contained device for enhancing circulation
USD476421S1 (en) * 2002-11-12 2003-06-24 Zimmer, Inc. Tourniquet pressure control apparatus
USD517695S1 (en) * 2004-02-23 2006-03-21 Tyco Healthcare Group Ip Compression sleeve
USD523147S1 (en) * 2004-02-23 2006-06-13 Tyco Healthcare Group Lp Compression sleeve
USD642281S1 (en) * 2008-11-21 2011-07-26 Empi, Inc. Electrical stimulation controller
USD672727S1 (en) * 2010-07-09 2012-12-18 Invacare Corporation Controller
US20120209153A1 (en) * 2011-02-14 2012-08-16 Farrow Mark A Deep vein thrombosis therapy device
USD701610S1 (en) * 2012-01-13 2014-03-25 Modular Therapeutx, Llc Remote controller for portable TENS device

Patent Citations (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3552383A (en) 1969-01-08 1971-01-05 Ibm Method and system for estimation of arterial pressure
GB1323365A (en) 1969-11-14 1973-07-11 Minnesota Mining & Mfg Disposable blood pressure cuff
US4294261A (en) 1976-06-01 1981-10-13 The United States Of America As Represented By The United States National Aeronautics And Space Administration Logic-controlled occlusive cuff system
US4106002A (en) 1976-12-06 1978-08-08 Hogue Jr Robert J Tourniquet pressure monitor
US4206764A (en) 1976-12-08 1980-06-10 Weisman & Allen Method and apparatus for analyzing cardiovascular systems
US4321929A (en) 1979-10-12 1982-03-30 Lemelson Jerome H Tourniquet
WO1983000995A1 (en) 1981-09-28 1983-03-31 Clark, Nancy, G. Pressure-responsive tourniquet
US4629433A (en) 1982-09-29 1986-12-16 Magid Sidney H Inflatable articles and method of making same
US4690151A (en) 1984-11-22 1987-09-01 Omron Tateisi Electronics Co. Blood pressure measuring apparatus
US4664651A (en) 1985-03-01 1987-05-12 The Procter & Gamble Company Subatmospheric method and apparatus for expanding blood vessels to facilitate puncture with a cannula
US5135003A (en) 1987-08-11 1992-08-04 Terumo Kabushiki Kaisha Automatic sphygmomanometer
JPH021221A (en) 1988-01-27 1990-01-05 Terumo Corp Cuff for measuring blood pressure and blood pressure measuring device having the same cuff
US5267565A (en) 1988-02-18 1993-12-07 Beard Jonathan D Method and apparatus for determining the patency of a blood vessel
US4967758A (en) 1988-12-08 1990-11-06 Prospect Holdings, Inc. Disposable cover/liner for blood pressure measuring devices
US5072736A (en) 1990-01-19 1991-12-17 Nihon Kohden Corporation Non-invasive automatic blood pressure measuring apparatus
WO1991018571A1 (en) 1990-06-01 1991-12-12 Richard Crangle Disposable multi-use pressurized bandage system
US5201758A (en) 1992-01-07 1993-04-13 Boehringer Mannheim Corporation Disposable tourniquet cuff
US5651369A (en) 1992-01-13 1997-07-29 Tomita; Mitsuei Apparatus for detecting and displaying blood circulatory information
JPH0751276A (en) 1993-05-27 1995-02-28 Heinrich Ulrich Apparatus for inducing bloodlessness at extremities of patient
US5569304A (en) 1993-05-27 1996-10-29 Ulrich; Heinrich C. Apparatus for inducing bloodlessness at the extremities of a patient
US5634467A (en) 1993-11-08 1997-06-03 Robin Medical Technologies Method and apparatus for assessing cardiovascular performance
US5643315A (en) 1994-09-22 1997-07-01 Daneshvar; Yousef Device for wound therapy and prevention of bleeding
US5687732A (en) 1994-10-07 1997-11-18 Omron Corporation Blood pressure monitor
US5830198A (en) * 1994-10-11 1998-11-03 Stryker Corporation Blood conservation system
US5970548A (en) 1995-02-14 1999-10-26 Welch; Robert Dudley Pleated sac for patient support mattress
US5571075A (en) 1995-04-28 1996-11-05 Bullard; Horace Method for exercise and simultaneous movement of blood by external pressure
JP2001505472A (en) 1997-01-08 2001-04-24 バイオセンス・インコーポレイテッド Monitoring of revascularization of the heart muscle
WO1998030144A1 (en) 1997-01-08 1998-07-16 Biosense Inc. Monitoring of myocardial revascularization
US6210423B1 (en) 1998-01-29 2001-04-03 Sinil Kim Bone marrow shielding apparatus and method of bone marrow-shielded cancer chemotherapy
US20010029389A1 (en) 1998-01-29 2001-10-11 Sinil Kim Bone marrow shielding apparatus and method of bone marrow-shielded cancer chemotherapy
EP0960598A1 (en) 1998-05-28 1999-12-01 Microlife Systems AG A method and a device for noninvasive measurement of the blood pressure and for detection of arrhythmia
US6485429B2 (en) 1998-05-28 2002-11-26 Microlife Intellectual Property Gmbh Method and a device for non-invasive measurement of the blood pressure and for detection of arrhythmia
US6905456B1 (en) 1998-06-26 2005-06-14 B.M.R.A. Corporation B.V. Intermittent compression device
US20030013974A1 (en) 1998-08-07 2003-01-16 Ananth Natarajan Implantable myocardial ischemia detection, indication and action technology
EP1016379A1 (en) 1998-12-31 2000-07-05 Depuy Orthopaedics, Inc. Gel tourniquet cuff
US6344025B1 (en) * 1999-02-19 2002-02-05 Omron Corporation Blood pressure monitor
US7485131B2 (en) 1999-03-29 2009-02-03 Stryker Corporation System and method for controlling pressure in a surgical tourniquet
US20030065270A1 (en) 1999-03-29 2003-04-03 Raines Jeffrey K. Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
WO2000057776A1 (en) 1999-03-29 2000-10-05 Vasocor, Inc. Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
US6152881A (en) 1999-03-29 2000-11-28 Vasocor, Inc. Calibrated measurement of blood vessels and endothelium after reactive hyperemia and method therefor
JP2002539879A (en) 1999-03-29 2002-11-26 ヴァーソカー インコーポレイテッド Calibration measurements and method of vascular and endothelial after reactive hyperemia
US6251080B1 (en) * 1999-05-13 2001-06-26 Del Mar Medical Systems, Llc Self contained ambulatory blood pressure cincture
US6245023B1 (en) 1999-08-19 2001-06-12 Critikon Company, Llc Conical blood pressure cuff with rectangular bladder
US6550482B1 (en) 2000-04-21 2003-04-22 Vascular Control Systems, Inc. Methods for non-permanent occlusion of a uterine artery
US20030176795A1 (en) 2000-06-02 2003-09-18 Harris Thomas John Blood pressure measurement apparatus and method
US6626840B2 (en) 2000-06-12 2003-09-30 Rutgers, The State University Of New Jersey Method and system for detecting vascular conditions using an occlusive arm cuff plethysmograph
JP2002156773A (en) 2000-09-08 2002-05-31 Ricoh Co Ltd Electrophotographic photoreceptor, method for forming image by using the same, image forming device, process cartridge for the image forming device
US7314478B2 (en) 2000-11-10 2008-01-01 Vasomedical, Inc. High efficiency external counterpulsation apparatus and method for controlling same
US6962599B2 (en) 2000-11-10 2005-11-08 Vasomedical, Inc. High efficiency external counterpulsation apparatus and method for controlling same
US7374540B2 (en) 2001-04-05 2008-05-20 Itamar Medical Ltd. Non-invasive probe for detecting medical conditions
EP1249218A2 (en) 2001-04-11 2002-10-16 Colin Corporation Venous thromboembolism preventing apparatus
US6702720B2 (en) 2001-04-24 2004-03-09 Lifewaves International, Inc. Systems and methods for breathing exercise regimens to promote ischemic preconditioning
US20050159640A1 (en) 2001-04-24 2005-07-21 Coaxia, Inc. Cerebral perfusion augmentation
US7338410B2 (en) 2001-04-24 2008-03-04 Lifewaves International Inc. Systems and methods for breathing exercise regimens to promote ischemic preconditioning
US20040044290A1 (en) 2001-09-21 2004-03-04 Ward Kevin R Methods for monitoring and optimizing central venous pressure and intravascular volume
US20050070405A1 (en) 2001-10-02 2005-03-31 Norbert Egger Fitness device
USRE42754E1 (en) * 2001-12-19 2011-09-27 Welch Allyn, Inc. Blood pressure measuring apparatus
US20040255956A1 (en) 2001-12-21 2004-12-23 Jakob Vinten-Johansen Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs
US6719704B2 (en) 2002-05-14 2004-04-13 Colin Corporation Vascular endothelial cell function evaluating apparatus
US7228576B2 (en) 2002-05-15 2007-06-12 Non-Invasive Monitoring Systems, Inc. Reciprocating movement platform for the external addition of pulses to the fluid channels of a subject
US7111346B2 (en) 2002-05-15 2006-09-26 Non-Invasive Monitoring Systems, Inc. Reciprocating movement platform for the external addition of pulses of the fluid channels of a subject
US7048702B2 (en) 2002-06-13 2006-05-23 Vasomedical, Inc. External counterpulsation and method for minimizing end diastolic pressure
US20030233118A1 (en) 2002-06-13 2003-12-18 Hui John C. K. Method for treating congestive heart failure using external counterpulsation
US20040064076A1 (en) 2002-09-27 2004-04-01 Jagadish Bilgi External chest therapy blanket for infants
US20040102818A1 (en) 2002-11-26 2004-05-27 Hakky Said I. Method and system for controlling blood pressure
US7018335B2 (en) 2003-03-03 2006-03-28 Omron Healthcare Co., Ltd. Blood pressure monitor and cardiovascular disease risk analyzing program
US6858012B2 (en) 2003-03-28 2005-02-22 Applied Cardiac Systems, Inc. System and method for generating external counterpulsation reports
US20030216651A1 (en) 2003-03-28 2003-11-20 Applied Cardiac Systems, Inc. System and method for generating external counterpulsation reports
US20050004476A1 (en) 2003-05-28 2005-01-06 Saeed Payvar Method and apparatus for detecting ischemia
US20040241634A1 (en) 2003-06-02 2004-12-02 Organ Recovery Systems Method and apparatus for pressure control for maintaining viability of organs
US20070197943A1 (en) 2003-07-18 2007-08-23 Pneu Medex Inc. Fluid operated actuators and pneumatic unloading orthoses
US7404221B2 (en) 2003-08-04 2008-07-29 Non-Invasive Monitoring Systems, Inc. Reciprocating movement platform for the external addition of pulses to the fluid channels of a subject
WO2005011503A1 (en) 2003-08-05 2005-02-10 The University Of Queensland Apparatus and method for early detection of cardiovascular disease using vascular imaging
US7390303B2 (en) 2003-09-30 2008-06-24 Ehud Dafni Assessment of vascular dilatation
US20050177078A1 (en) 2003-10-07 2005-08-11 Loeb Marvin P. External counter pulsation treatment
US7517312B2 (en) 2003-10-07 2009-04-14 Cardiomedics, Inc. External counter pulsation treatment
WO2005051250A1 (en) 2003-11-30 2005-06-09 Flowmedic Limited A method and apparatus for enhancement of circulation within cast incased body part
US20070055188A1 (en) 2003-11-30 2007-03-08 Flowmedic Limited Supportive structure and circulation enhancing apparatus
RU2253429C1 (en) 2003-12-02 2005-06-10 Государственное образовательное учреждение высшего профессионального образования Московская медицинская академия им. И.М. Сеченова МЗ РФ Method and pneumostocking device for treating obliterating diseases of limb arteries
US9723985B2 (en) * 2003-12-08 2017-08-08 Nihon Kohden Corporation Vital sign telemeter
US20050171444A1 (en) 2003-12-08 2005-08-04 Nihon Kohden Corporation Vital sign telemeter
US7427268B2 (en) 2004-02-03 2008-09-23 Pharma-Smart, Llc Ring-shaped cuff for measurement of blood pressure
US7166077B2 (en) 2004-02-03 2007-01-23 Pharma-Smart, Llc Cuff for measurement of blood pressure
WO2005077265A1 (en) 2004-02-18 2005-08-25 Miklos Illyes Apparatus and method for measuring hemodynamic parameters
US7004907B2 (en) 2004-04-07 2006-02-28 Triage Wireless, Inc. Blood-pressure monitoring device featuring a calibration-based analysis
US20100322467A1 (en) 2004-07-02 2010-12-23 Reed Alastair M Steganographic Encoding and Decoding
WO2006024871A1 (en) 2004-09-03 2006-03-09 King's College London Methods and apparatus for the measurement of blood pressure
US20060052713A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
US20060052714A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
US20060052712A1 (en) 2004-09-07 2006-03-09 Biomedix, Inc. Vascular testing system
US20060058717A1 (en) 2004-09-14 2006-03-16 Hui John C K External counterpulsation device having a curvilinear bed
WO2006030441A2 (en) 2004-09-15 2006-03-23 Itamar Medical Ltd. Measuring blood flow and venous capacitance
US20060100639A1 (en) 2004-11-05 2006-05-11 G&L Consulting, Llc System and method for the treatment of reperfusion injury
WO2006061825A2 (en) 2004-12-07 2006-06-15 Exerflow Medical Ltd External counterpulsation device and method
US20060142663A1 (en) 2004-12-10 2006-06-29 Omron Healthcare Co., Ltd. Electronic blood pressure monitor and blood pressure measuring system
US20070005106A1 (en) 2005-06-30 2007-01-04 Adducci James P Systems and methods to facilitate muscular benefit using vascular occlusion
US20070135836A1 (en) 2005-12-14 2007-06-14 Mcewen James A Low-cost disposable tourniquet cuff
US20070150005A1 (en) 2005-12-23 2007-06-28 Sih Haris J Method and apparatus for tissue protection against ischemia using remote conditioning
US7885710B2 (en) 2005-12-23 2011-02-08 Cardiac Pacemakers, Inc. Method and apparatus for tissue protection against ischemia using remote conditioning
US20070247304A1 (en) 2006-01-24 2007-10-25 Bristol-Myers Squibb Company Proximity detection apparatus
WO2007085828A1 (en) 2006-01-24 2007-08-02 Bristol-Myers Squibb Company Control unit assembly
WO2007085816A1 (en) 2006-01-24 2007-08-02 Bristol-Myers Squibb Company A proximity detection apparatus
US20090036785A1 (en) 2006-02-01 2009-02-05 Per Danielsson Blood pressure monitor
WO2007087707A1 (en) 2006-02-03 2007-08-09 Western Clinical Engineering Ltd. Low-cost disposable tourniquet cuff
US20100081941A1 (en) 2006-03-22 2010-04-01 Endothelix, Inc. Cardiovascular health station methods and apparatus
US7689286B2 (en) 2006-05-02 2010-03-30 Cardiac Pacemakers, Inc. Myocardium conditioning using myocardial and parasympathetic stimulation
US20090324748A1 (en) 2006-07-25 2009-12-31 Hibernation Therapeutics Limited Trauma therapy
US20080077176A1 (en) 2006-09-21 2008-03-27 Tyco Healthcare Group Lp Safety connector assembly
US8783499B2 (en) * 2006-11-16 2014-07-22 Sangenic International Limited Waste storage device
US9119759B2 (en) * 2006-12-06 2015-09-01 The Hospital For Sick Children System for performing remote ischemic preconditioning
US20080139949A1 (en) 2006-12-06 2008-06-12 The Hospital For Sick Children System for performing remote ischemic preconditioning
US8790266B2 (en) 2006-12-06 2014-07-29 The Hospital For Sick Children Methods and system for performing remote ischemic preconditioning
US20120277789A1 (en) 2006-12-06 2012-11-01 The Hospital For Sick Children Methods and system for performing remote ischemic preconditioning
US20100305607A1 (en) 2006-12-06 2010-12-02 The Hospital For Sick Children System for performing remote ischemic preconditioning
US7717855B2 (en) 2006-12-06 2010-05-18 The Hospital For Sick Children System for performing remote ischemic preconditioning
US20100160799A1 (en) 2006-12-06 2010-06-24 The Hospital For Sick Children Methods and system for performing remote ischemic preconditioning
US9119761B2 (en) * 2006-12-06 2015-09-01 The Hospital For Sick Children Methods and system for performing remote ischemic preconditioning
US20080222769A1 (en) 2007-03-15 2008-09-18 Hillary Natonson Garment-integrated proprioceptive feedback system
US20100105993A1 (en) 2007-05-23 2010-04-29 Ic Therapeutics, Inc. Methods and apparatus for noninvasive ischemic conditioning
WO2008148062A1 (en) 2007-05-23 2008-12-04 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
US20100185220A1 (en) 2007-05-23 2010-07-22 Ic Therapeutics, Inc. Apparatus and methods for controlled ischemic conditioning
WO2008148045A1 (en) 2007-05-23 2008-12-04 Ic Therapeutics, Inc. Methods and apparatus for noninvasive ischemic conditioning
WO2009049103A2 (en) 2007-10-09 2009-04-16 Sleep Improvement Center P.C. Blood clot prevention device
US20100268130A1 (en) 2007-10-09 2010-10-21 Khan Sitara R Blood clot prevention device
CN101317805A (en) 2007-11-01 2008-12-10 吉训明;罗玉敏;党 莎;赵士勇;陈 俊 Cerebrovascular and cardiovascular health care therapeutic instrument
CN201098315Y (en) 2007-11-01 2008-08-13 吉训明;罗玉敏;陈 俊;党 莎;赵士勇 Cerebrovascular and cardiovascular health care therapeutic instrument
US20090124912A1 (en) 2007-11-09 2009-05-14 Western Clinical Engineering Ltd. Tourniquet Apparatus for Measuring Limb Occlusion Pressure
US20090137884A1 (en) 2007-11-25 2009-05-28 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US8246548B2 (en) 2007-11-25 2012-08-21 Morteza Naghavi Ischemic conditioning for improved athletic performance
US20090287069A1 (en) 2007-11-25 2009-11-19 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US8986342B2 (en) * 2007-11-25 2015-03-24 Ic Therapeutics Methods and apparatus for repeated ischemic conditioning treatment of hypertension and other medical conditions
US20100328142A1 (en) 2008-03-20 2010-12-30 The Curators Of The University Of Missouri Microwave and millimeter wave resonant sensor having perpendicular feed, and imaging system
US20090318818A1 (en) 2008-06-20 2009-12-24 Welch Allyn, Inc. Blood pressure monitoring system
US8123694B2 (en) * 2008-07-18 2012-02-28 Welch Allyn, Inc. Electro pneumatic interface for blood pressure system
EP2168553A1 (en) 2008-09-30 2010-03-31 Tyco Healthcare Group LP Tubeless Compression Device
US20100081977A1 (en) 2008-09-30 2010-04-01 Tyco Healthcare Group Lp Tubeless Compression Device
CN201316381Y (en) 2008-11-11 2009-09-30 首都医科大学宣武医院 Low oxygen saturation human body protecting training instrument
US20100186752A1 (en) 2009-01-28 2010-07-29 Sandy Rixson Disposable cuff liner for use with a blood pressure cuff
US20100292619A1 (en) 2009-05-13 2010-11-18 The Hospital For Sick Children Performance enhancement
WO2010132115A1 (en) 2009-05-13 2010-11-18 The Hospital For Sick Children Performance enhancement
US8672854B2 (en) * 2009-05-20 2014-03-18 Sotera Wireless, Inc. System for calibrating a PTT-based blood pressure measurement using arm height
US8753283B2 (en) * 2009-06-23 2014-06-17 Infarct Reduction Technologies Inc. Automatic devices for remote ischemic preconditioning
US8114026B2 (en) * 2009-06-23 2012-02-14 Infarct Reduction Technologies Inc. Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
US9610213B2 (en) * 2009-06-23 2017-04-04 Lifecuff Technologies Inc. Automatic devices for remote ischemic preconditioning
US20120130419A1 (en) 2009-06-23 2012-05-24 Infarct Reduction Technologies Inc. Automatic devices for remote ischemic preconditioning
US20100324429A1 (en) * 2009-06-23 2010-12-23 Boris Leschinsky Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
WO2011005538A2 (en) 2009-06-23 2011-01-13 Boris Leschinsky Methods and devices for remote ischemic preconditioning and near-continuous blood pressure monitoring
US20100326442A1 (en) 2009-06-26 2010-12-30 Hamilton Robert M Resuscitation/respiration system
US9492094B2 (en) * 2009-07-31 2016-11-15 Omron Healthcare Co., Ltd. Blood pressure monitor
EP2301496A1 (en) 2009-09-29 2011-03-30 Tyco Healthcare Group LP Pneumatic compression garment with noise attenuating means
US20110077566A1 (en) 2009-09-29 2011-03-31 Tyco Healthcare Group Lp Pneumatic compression garment with noise attenuating means
US20110152650A1 (en) 2009-12-21 2011-06-23 General Electric Company Adaptive pump control during non-invasive blood pressure measurement
US9743744B2 (en) * 2010-01-28 2017-08-29 Koniklijike Philips N.V. Module retainer
US20110190807A1 (en) 2010-02-01 2011-08-04 The Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
US20110238107A1 (en) 2010-03-25 2011-09-29 Fazal Raheman Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
US8911469B2 (en) 2010-03-25 2014-12-16 Neocardium, Limited Methods and apparatus for optimal remote ischemic preconditioning (ORIP) for preventing ischemia-reperfusion injuries to organs
US20110240043A1 (en) 2010-03-31 2011-10-06 The Hospital For Sick Children Use of remote ischemic conditioning to improve outcome after myocardial infarction
US9393025B2 (en) * 2010-04-08 2016-07-19 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
US20110251635A1 (en) 2010-04-08 2011-10-13 The Hospital For Sick Children Use of remote ischemic conditioning for traumatic injury
WO2012024342A1 (en) 2010-08-16 2012-02-23 Breathe Technologies, Inc. Methods, systems and devices using lox to provide ventilatory support
US20130317581A1 (en) 2010-12-30 2013-11-28 The Hospital For Sick Children Methods and devices relating to non-invasive electrical nerve stimulation
US9439574B2 (en) * 2011-02-18 2016-09-13 Sotera Wireless, Inc. Modular wrist-worn processor for patient monitoring
US20140024986A1 (en) 2011-03-31 2014-01-23 Terumo Kabushiki Kaisha Limb compression device and control method
US9205019B2 (en) * 2011-04-15 2015-12-08 CellAegis Devices Inc. System for performing remote ischemic conditioning
US20140296756A1 (en) 2011-04-15 2014-10-02 CellAegis Devices Inc. System for performing remote ischemic conditioning
US8764789B2 (en) * 2011-04-15 2014-07-01 CellAegis Devices Inc. System for performing remote ischemic conditioning

Non-Patent Citations (54)

* Cited by examiner, † Cited by third party
Title
Addison et al., "Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction," Am. J. Physiol. Heart Circ. Physiol., vol. 285, pp. 1435-1443 (2003).
Ali et al., Remote ischemic preconditioning reduces myocardial and renal injury after elective abdominal aortic aneurysm repair: a randomized controlled trial,: Circulation, vol. 116, 11 Suppl., pp. 98-105 (Sep. 2007).
Bartekova et al., "Liver ischemia induced remote preconditioning: role of cardioprotective proteins," ISHR-ES Meeting, J. Mol. Cell Cardiol., vol. 38, Issue No. 6, p. 1004 (Jun. 21-25, 2005).
Botker et al., Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial, Lancet, vol. 375, Issue No. 9716, pp. 727-734 (Feb. 2010).
Bøtker et al., Upper-limb ischemia during ambulance transfer reduces myocardial perfusion injury in STEMI. Heartwire. Mar. 28, 2009. Featured at i2 Session of AAC. Mar. 28-31, 2009. Last Accessed on Mar. 5, 2012 from http://www.theheart.org/article/951627.do.
Brzozowski et al., "Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves," Eur. J. Pharmacol., vol. 499, Issue Nos. 1-2, pp. 201-213 (Sep. 2004).
Brzozowski et al., "Ischemic preconditioning of remote organs attenuates gastric ischemia—reperfusion injury through involvement of prostaglandins and sensory nerves," Eur. J. Pharmacol., vol. 499, Issue Nos. 1-2, pp. 201-213 (Sep. 2004).
Cheung et al., "Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans," J. Am. Coll. Cardiol., vol. 47, Issue No. 11, pp. 2277-2282 (Jun. 2006).
Dickson et al., "Rabbit heart can be "preconditioned" via transfer of coronary effluent," Am. J. Physiol., vol. 277, Issue No. 6, Pt. 2, pp. H2451-H2457 (Dec. 1999).
Dong et al., "Limb ischemic preconditioning reduces infarct size following myocardial ischemia-reperfusion in rats," vol. 56, Issue No. 1, pp. 41-46 (Feb. 2004) [Chinese].
Dong et al., "Limb ischemic preconditioning reduces infarct size following myocardial ischemia-reperfusion in rats," vol. 56, Issue No. 1, pp. 41-46 (Feb. 2004) [English abstract].
Gho et al., "Myocardial protection by brief ischemia in noncardiac tissue," Circulation, vol. 94, Issue No. 9, pp. 2193-2200 (Nov. 1996).
Hausenloy et al., "Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial," Lancet, vol. 370, Issue No. 9587, pp. 575-579 (Aug. 2007).
Hausenloy et al., "Preconditioning and postconditioning: underlying mechanisms and clinical application," Atherosclerosis, vol. 204, Issue No. 2, pp. 334-341 (Jun. 2009).
Hausenloy et al., "The therapeutic potential of ischemic conditioning: an update," Nat. Rev. Cardiol., vol. 8, Issue No. 11, pp. 619-629 (Jun. 2011).
Hoole et al., "Cardiac Remote Ischemic Preconditioning in Coronary Stenting (Crisp Stent) Study: a prospective, randomized control trial" Circulation, vol. 119, Issue No. 6, pp. 820-827 (Feb. 2009).
Jenkins et al., "Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery," Heart, vol. 77, Issue No. 4, pp. 314-318 (Apr. 1997).
Kharbanda et al., "Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo," Circulation, vol. 103, Issue No. 12, pp. 1624-1630 (Mar. 2001).
Kharbanda et al., "Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study," Heart, vol. 92, Issue No. 10, pp. 1506-1511 (Eur. Pub-Jul. 2006).
Kharbanda et al., "Transient limb ischemia induces remote ischemic preconditioning in vivo," Circulation, vol. 106, Issue No. 23, pp. 2881-2883 (Dec. 2002).
Kharbanda et al., "Translation of remote ischaemic preconditioning into clinical practice," Lancet, vol. 374, Issue No. 9700, pp. 1557-1565 (Oct. 2009).
Kharbanda et al., "Remote ischaemic preconditioning protects against cardiopulmonary bypass-induced tissue injury: a preclinical study," Heart, vol. 92, Issue No. 10, pp. 1506-1511 (Eur. Pub—Jul. 2006).
Konstantinov et al., "Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism," Transplantation, vol. 79, Issue No. 12, pp. 1691-1695 (Jun. 2005).
Konstantinov et al., "The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium," J. Thorac. Cardiovasc. Surg., vol. 130, Issue No. 5, pp. 1326-1332 (Nov. 2005).
Konstantinov et al., "The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans," Physiol Genomics, vol. 19, No. 1, pp. 143-150 (Sep. 2004).
Lang et al., "Myocardial preconditioning and remote renal preconditioning-identifying a protective factor using proteomic methods?," Basic Res. Cardiol., vol. 101, Issue No. 2, pp. 149-158 (Mar. 2006).
Lang et al., "Myocardial preconditioning and remote renal preconditioning—identifying a protective factor using proteomic methods?," Basic Res. Cardiol., vol. 101, Issue No. 2, pp. 149-158 (Mar. 2006).
Laskey et al., "Frequency and clinical significance of ischemic preconditioning during percutaneous coronary intervention," J. Am. Coll. Cardiol., vol. 24, Issue No. 6, pp. 998-1003 (Sep. 2003).
Leesar et al., "Nonelectrocardiographic evidence that both ischemic preconditioning and adenosine preconditioning exist in humans," J. Am. Coll. Cardiol., vol. 42, Issue No. 3, pp. 437-435 (Aug. 2003).
Leesar et al., "Preconditioning of human myocardium with adenosine during coronary angioplasty," Circulation, vol. 95, Issue No. 11, pp. 2500-2507 (Jun. 1997).
Loukogeorgakis et al., "Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system," J. Am. Coll. Cardiol., vol. 46, Issue No. 3, pp. 450-456 (Aug. 2005).
Loukogeorgakis et al., "Transient limb ischemia induces remote preconditioning and remote postconditioning in humans by a K(ATP)-channel dependent mechanism," Circulation, vol. 116, Issue No. 12, pp. 1386-1395 (Sep. 2007).
May 29, 2013 Office Action from U.S. Appl. No. 13/542,929.
McCully et al., "Adenosine-enhanced ischemic preconditioning: adenosine receptor involvement during ischemia and reperfusion," Am. J. Physiol. Heart Circ. Physiol., vol. 280, Issue No. 2, pp. H591-H602 (Feb. 2001).
Murray et al., "Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium," Circulation, vol. 74, Issue No. 5, pp. 1 124-1136 (Nov. 1986).
Nandagopal et al., "Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance," J. Pharmacol. Exp. Ther., vol. 297, Issue No. 2, pp. 474-478 (May 2001).
Peng et al., "The protective effects of ischemic and calcitonin gene-related peptide-induced preconditioning on myocardial injury by endothelin-1 in the isolated perfused rat heart," Life Sci., vol. 59, Issue No. 18, pp. 1507-1514 (1996).
Penttila et al., "Ischemic preconditioning does not improve myocardial preservation during off-pump multivessel coronary operation," Ann. Thorac. Surg., vol. 75, Issue No. 4, pp. 1246-1252 (Apr. 2003).
Peralta et al., "Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury," Transplant Proc., vol. 35, Issue No. 5, pp. 1800-1802 (Aug. 2003).
Product ad by Delfi Medical Innovations, Inc., (Delfi tourniquet)(2011).
Przyklenk et al., "Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion," Circulation, vol. 87, Issue No. 3, pp. 893-899 (Mar. 1993).
Przyklenk et al., "Regional ischemic ‘preconditioning’ protects remote virgin myocardium from subsequent sustained coronary occlusion," Circulation, vol. 87, Issue No. 3, pp. 893-899 (Mar. 1993).
Redington et al., "Exploring remote ischaemic preconditioning," Internal Innovation, pp. 42-44 www.research.media.eu.
Saxena et al., "Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application," J. Card. Surg., vol. 25, Issue No. 1, pp. 127-134 (Jan.-Feb. 2010).
Schmidt et al., "Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic preconditioning," Am. J. Physiol. Heart Circ. Physiol., vol. 292, Issue No. 4, pp. H1883-H1890 (Apr. 2007).
Schoemaker et al., "Bradykinin mediates cardiac preconditioning at a distance," Am. J. Physiol. Heart Circ. Physiol., vol. 278, Issue No. 5, pp. H1571-1576 (May 2000).
Search Report from PCT Application No. PCT/US2012/033442, no date.
Takarada et al., "Applications of vascular occlusion diminish disuse atrophy of knee extensor muscles," ed. Sci. Sports. Exerc., vol. 32, Issue No. 12, pp. 2035-2039 (Dec. 2000).
Takarada et al., "Applications of Vascular Occlusion Diminish Disuse Atrophy of Knee Extensor Muscles," Official Journal of the American College of Sports Medicine, Medicine and Science in Sports and Exercise, pp. 2035-2039 (Apr. 2000).
Tanaka et al., "Expression of heat shock protein after ischemic preconditioning in rabbit hearts," Jpn. Circ J., vol. 62, Issue No. 7, pp. 512-516 (Jul. 1998).
Tejwani et al., "Tourniquet cuff pressure: The gulf between science and practice," J. Trauma, vol. 61, Issue No. 6, pp. 1415-1418 (Dec. 2006).
Tomai et al., "Ischemic preconditioning in humans: models, mediators, and clinical relevance," Circulation, vol. 100, Issue No. 5, pp. 559-563 (Aug. 1999).
Wolfrum et al., "Calcitonin gene related peptide mediates cardioprotection by remote preconditioning," Regal. Pept., vol. 127, Issue Nos. 1-3 (Apr. 2005).
Written Opinion from PCT Application No. PCT/US2012/033442, no date.

Also Published As

Publication number Publication date
TW201811289A (en) 2018-04-01
CN103796598B (en) 2016-08-17
TW201247192A (en) 2012-12-01
USD709048S1 (en) 2014-07-15
WO2012142360A2 (en) 2012-10-18
US20140296756A1 (en) 2014-10-02
AU2012242724B2 (en) 2015-01-22
US8764789B2 (en) 2014-07-01
AU2012242724A1 (en) 2013-05-02
CN103796598A (en) 2014-05-14
CA2870434A1 (en) 2012-10-18
USD709197S1 (en) 2014-07-15
EP2696781A2 (en) 2014-02-19
TWI612956B (en) 2018-02-01
US9205019B2 (en) 2015-12-08
US20120265240A1 (en) 2012-10-18
CN106420300A (en) 2017-02-22
WO2012142360A3 (en) 2013-01-31

Similar Documents

Publication Publication Date Title
JP2713984B2 (en) Improved inflatable bed apparatus, and a method of controlling the firmness of an inflatable bed
US6468237B1 (en) Pneumatic pump, housing and methods for medical purposes
US6746470B2 (en) Emergency and military tourniquet for pre-hospital use
DE69232572T2 (en) Pneumatic compression device and method for use in the medical field
US7597659B2 (en) Suprapatellar external counterpulsation apparatus
CA2060910C (en) Protective boot structure
US20050159690A1 (en) Method and apparatus for assisting vascular flow through external compression synchronized with venous phasic flow
US5383893A (en) Device for preventing post-catherization wound bleeding
AU2007216669B2 (en) Compression device, system and method of use
CA1080072A (en) Inflatable anti-shock and splinting trousers
US5201758A (en) Disposable tourniquet cuff
US7794405B2 (en) Cuff for blood pressure monitor, and blood pressure monitor having the same
US2899955A (en) Respirator belt
CA2570612C (en) Compression apparatus
US5354260A (en) Slipper with an inflatable foot pump
US20100100018A1 (en) Orthopedic walker boot having an inflatable bladder
KR20130089219A (en) Compression garment apparatus having baseline pressure
US20070282230A1 (en) Systems and methods for applying reversed sequence pressure to control edema flow
US4301791A (en) Body transfer unit
US5891065A (en) Mobile extremity pumping apparatus
US5433724A (en) Compressive hemostatic belt
US20050182331A1 (en) Cuff for measurement of blood pressure
KR101304177B1 (en) Compression garment apparatus having support bladder
JP5843367B2 (en) Staged compression device for treating circulatory system disorders
US20060020236A1 (en) Disposable compression sleeve

Legal Events

Date Code Title Description
FEPP Fee payment procedure

Free format text: ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: BIG.); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY

FEPP Fee payment procedure

Free format text: ENTITY STATUS SET TO SMALL (ORIGINAL EVENT CODE: SMAL); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY