US9949657B2 - Displaying multiple-activation areas on an electroanatomical map - Google Patents

Displaying multiple-activation areas on an electroanatomical map Download PDF

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US9949657B2
US9949657B2 US14/960,904 US201514960904A US9949657B2 US 9949657 B2 US9949657 B2 US 9949657B2 US 201514960904 A US201514960904 A US 201514960904A US 9949657 B2 US9949657 B2 US 9949657B2
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activation
activation area
heart
display
processor
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Eliyahu Ravuna
Lior Botzer
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Biosense Webster Israel Ltd
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Biosense Webster Israel Ltd
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Assigned to BIOSENSE WEBSTER (ISRAEL) LTD. reassignment BIOSENSE WEBSTER (ISRAEL) LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BOTZER, LIOR, RAVUNA, ELIYAHU
Priority to AU2016253655A priority patent/AU2016253655A1/en
Priority to IL248883A priority patent/IL248883B/en
Priority to CA2949991A priority patent/CA2949991A1/fr
Priority to JP2016236505A priority patent/JP6830805B2/ja
Priority to EP16202441.8A priority patent/EP3178391B1/fr
Priority to CN201611115292.9A priority patent/CN106901718B/zh
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Definitions

  • the present invention relates to the field of electroanatomical mapping, specifically of the heart.
  • a “local activation time” of a particular area of the heart is the time at which the wavefront of electrical propagation passes through the area.
  • a local activation time is typically measured from a particular reference time, such as a particular point in time in the QRS complex of a body-surface electrocardiogram (ECG) recording.
  • ECG body-surface electrocardiogram
  • a method for displaying electroanatomical information includes identifying at least one multiple-activation area of a surface of a heart, at which multiple-activation area were recorded at least two different local activations during a single cardiac cycle of the heart.
  • the multiple-activation area is displayed, on an electroanatomical map of the surface of the heart, in a manner that indicates a time difference between respective times of the two local activations.
  • displaying the multiple-activation area includes displaying the multiple-activation area in a color that indicates the time difference.
  • displaying the multiple-activation area includes displaying the multiple-activation area with an overlaid indicator, a property of which indicates the time difference.
  • the property of the overlaid indicator includes a color of the overlaid indicator.
  • the property of the overlaid indicator includes a size of the overlaid indicator.
  • displaying the multiple-activation area includes setting a value of a display property of the multiple-activation area by applying, to the time difference, a function that maps a domain of time differences to a range of values of the display property.
  • the function (i) is monotonic for time differences that lie between an upper limit and a lower limit, (ii) returns a first value for the lower limit, and (iii) is constant, at a second value, for differences that lie above the upper limit.
  • the method further includes receiving from a user, via a user interface, the upper limit and the lower limit.
  • the method further includes receiving from the user, via the user interface, the first value and the second value.
  • the method further includes:
  • displaying the single-activation area includes setting a color of the single-activation area by applying, to the time of the single local activation, a first function that maps a domain of times to a first range of color values, and
  • displaying the multiple-activation area includes setting a color of the multiple-activation area by applying, to the time difference, a second function that maps a domain of time differences to a second range of color values that is distinct from the first range.
  • the multiple-activation area includes an area of the heart that was ablated.
  • apparatus for use with a display.
  • the apparatus includes an electrical interface, and a processor, configured to (i) receive, via the electrical interface, one or more electrocardiogram (ECG) signals, (ii) from the ECG signals, identify at least one multiple-activation area of a surface of a heart, at which multiple-activation area were recorded at least two different local activations during a single cardiac cycle of the heart, and (iii) drive the display to display, on an electroanatomical map of the surface of the heart, the multiple-activation area in a manner that indicates a time difference between respective times of the two local activations.
  • ECG electrocardiogram
  • a computer software product including a tangible non-transitory computer-readable medium in which program instructions are stored.
  • the instructions when read by a processor, cause the processor to (i) identify at least one multiple-activation area of a surface of a heart, at which multiple-activation area were recorded at least two different local activations during a single cardiac cycle of the heart, and (ii) drive a display to display, on an electroanatomical map of the surface of the heart, the multiple-activation area in a manner that indicates a time difference between respective times of the two local activations.
  • FIG. 1 is a schematic illustration of a system for generating an electroanatomical map of an inner or epicardial surface of a heart, in accordance with some embodiments of the present invention
  • FIGS. 2-3 are schematic illustrations of visual output, displayed in accordance with some embodiments of the present invention.
  • FIG. 4 is a flow diagram for a method for displaying an electroanatomical map of an inner or epicardial surface of a heart, in accordance with some embodiments of the present invention.
  • the distal end of a catheter is moved along the inner or epicardial surface of a heart, and one or more electrodes at the distal end of the catheter are used to record the electrical activity of the heart.
  • the electrodes may be used to record intracardiac ECG signals, from which the respective local activation times at various areas may be identified. Such information may be used to generate an electroanatomical map.
  • some areas of the inner or epicardial surface of the heart exhibit two or more local activations per cardiac cycle.
  • Multiple local activations in a particular area may be indicative of the presence of a line of block in the area.
  • Such a line of block may be pathological, or may be the intended result of an ablation procedure, referred to as a line of ablation.
  • the time difference between the local activations may indicate the proximity of the multiple-activation area to an edge of the line of block, or to an unintended gap in the line of ablation.
  • embodiments described herein provide methods and apparatus for displaying multiple-activation areas on an electroanatomical map, in an intuitive manner that indicates the respective time differences for the multiple-activation areas.
  • a function may be used to map the time differences to respective colors, such that the color in which a particular multiple-activation area is displayed on the map indicates the time difference for the multiple-activation area.
  • a physician may then use the electroanatomical map to locate, with relative precision, a pathological line of block, or to identify an unintended gap in a line of ablation.
  • An advantage of embodiments of the present invention is that the physician need not examine the “raw” intracardiac ECG signal in order to determine the time difference between activations for a multiple-activation area. Rather, the physician may readily perceive the time difference, simply by looking at the electroanatomical map. Moreover, since the electroanatomical map typically shows all of the multiple-activation areas at once, the physician may locate pathological tissue, or an unintended gap in a line of ablation, much more quickly and/or effectively, relative to if the physician were to examine each individual intracardiac ECG signal. Hence, embodiments of the present invention may improve the diagnosis and/or treatment of the subject.
  • FIG. 1 is a schematic illustration of a system 21 for generating an electroanatomical map of an inner or epicardial surface of a heart 23 of a subject 25 , in accordance with some embodiments of the present invention.
  • a system 21 for generating an electroanatomical map methods disclosed in U.S. Pat. Nos. 6,226,542, 6,301,496, and 6,892,091, whose disclosures are herein incorporated by reference, may be used.
  • One commercial product embodying elements of system 21 is the CARTO® 3 System, available from Biosense Webster, Inc., 3333 Diamond Canyon Road, Diamond Bar, Calif. 91765. This system may be modified by those skilled in the art to embody the principles of embodiments described herein.
  • FIG. 1 shows a physician 27 holding a catheter 29 , a distal end 31 of which is disposed within heart 23 of subject 25 .
  • Physician 27 moves distal end 31 of catheter 29 along the inner or epicardial surface of the heart, and one or more electrodes at the distal end of the catheter are used to record intracardiac ECG signals, as described above.
  • a processor (PROC) 28 receives the ECG signals via an electrical interface 35 .
  • processor 28 identifies any recorded local activations, and further measures the respective local activation times of the local activations, or at least the respective differences between any multiple local activations.
  • processor 28 In response to the measured local activation times and/or the time differences, processor 28 generates an electroanatomical map, and drives a display 26 to display the map, as described in detail below.
  • processor 28 may be embodied as a single processor, or a cooperatively networked or clustered set of processors.
  • Processor 28 is typically a programmed digital computing device comprising a central processing unit (CPU), random access memory (RAM), non-volatile secondary storage, such as a hard drive or CD ROM drive, network interfaces, and/or peripheral devices.
  • Program code, including software programs, and/or data are loaded into the RAM for execution and processing by the CPU and results are generated for display, output, transmittal, or storage, as is known in the art.
  • the program code and/or data may be downloaded to the computer in electronic form, over a network, for example, or it may, alternatively or additionally, be provided and/or stored on non-transitory tangible media, such as magnetic, optical, or electronic memory.
  • Such program code and/or data when provided to the processor, produce a machine or special-purpose computer, configured to perform the tasks described herein.
  • FIG. 2 is a schematic illustration of visual output 37 , which is displayed on display 26 in accordance with some embodiments of the present invention.
  • Visual output 37 includes an electroanatomical map 32 of an inner surface 34 of a heart (e.g., a portion of the left-ventricular or right-ventricular myocardium of the heart), which is generated by processor 28 in response to the local activation times of the recorded local activations.
  • FIG. 2 shows the anatomical scenario that leads to the display of map 32 as shown.
  • an electrical wavefront 24 propagates along surface 34 , as indicated by the arrow.
  • wavefront 24 Upon reaching the “near” side of a line of block 22 , wavefront 24 circumvents the line of block, and continues along its previous trajectory at the “far” side of the line of block.
  • multiple local activation times are measured in the vicinity of the line of block.
  • FIG. 2 depicts, via a plurality of “x” symbols, the measurement of local activation times at areas 30 a , 30 b , and 30 c that lie along the line of block.
  • the measured local activation times might be as follows:
  • Areas such as areas 30 a , 30 b , and 30 c are referred to herein as “multiple-activation areas.”
  • areas in which only a single local activation is recorded per cardiac cycle are referred to herein as “single-activation areas.”
  • single-activation areas areas in which only a single local activation is recorded per cardiac cycle.
  • the difference between the local activation times at a multiple-activation area is a function of the propagation time needed for wavefront 24 to circumvent the line of block, and is therefore a function of the proximity of the multiple-activation area to the edge of the line of block.
  • the difference between the local activation times is 50 ms for area 30 c , but only 10 ms for area 30 a , since area 30 a is closer to the edge of the line of block.
  • processor 28 Based on the measured local activation times, processor 28 identifies areas 30 a , 30 b , and 30 c as multiple-activation areas. Processor 28 then drives display 26 to display, on electroanatomical map 32 , each of the multiple-activation areas in a manner that indicates the time difference between the two local activation times measured at the area. For example, FIG. 2 shows each of areas 30 a , 30 b , and 30 c displayed in a color that indicates the time difference between the two local activation times measured at the area. In particular, area 30 a , at which a relatively small time difference was measured, is shown in a darker color, while area 30 c , at which a larger time difference was measured, is shown in a lighter color. Area 30 b is shown in an intermediate color. (It is noted that in the context of the present application, including the claims, black is considered to be a color.)
  • the processor sets a value of a display property of the multiple-activation area by applying, to the time difference, a function that maps a domain of time differences to a range of values of the display property.
  • a function that maps a domain of time differences to a range of values of the display property.
  • FIG. 2 depicts an embodiment in which the modified display property is the display color; hence, the processor applies a function that maps a domain of time differences delta-T ( ⁇ T) to a range of color values.
  • ⁇ T domain of time differences delta-T
  • the function that is used for displaying the multiple-activation areas (i) is monotonic (e.g., strictly monotonic) for time differences that lie between an upper limit and a lower limit, (ii) returns a first value for the lower limit, and (iii) is constant, at a second value, for differences that lie above the upper limit.
  • C2_R, C2_G, and C2_B are, respectively, the red (R), green (G), and blue (B) components of the color C2 in which the multiple-activation area is displayed, and C2_A is the opacity of the color.
  • this function maps the domain of time differences to the color range between black, represented by the RGBA vector (0,0,0,1), and white, represented by (1,1,1,1).
  • this function (i) is strictly monotonically (linearly) increasing, from 0 to 1 for ⁇ T values between 10 ms and 50 ms, (ii) returns 0 for ⁇ T values less than or equal to 10 ms, and (iii) returns 1 for ⁇ T values greater than or equal to 50 ms.
  • the scope of the present invention includes setting any relevant display property to indicate the time difference between the local activation times.
  • the multiple-activation area may be displayed with an overlaid indicator (e.g., a “+,” “x,” or “*” symbol), a property of which indicates the time difference between the two local activation times.
  • the color or size of the overlaid indicator may indicate the time difference.
  • a function may be used to map the relevant domain of time differences to the relevant range of values for the color or size of the indicator, analogously to that which was described above.
  • S is the size, in pixels, of the indicator.
  • Such a function returns a size of zero pixels for ⁇ T values equal to or less than 10 ms, a size of 10 pixels for ⁇ T values equal to or greater than 50 ms, and a size that varies linearly from zero to 10 pixels for ⁇ T values between 10 ms and 50 ms.
  • mapping function is linearly increasing between the upper and lower time-difference limits.
  • mapping function may be exponential or logarithmic, or may take any other suitable form.
  • the upper and lower limits of the domain for the monotonically varying portion of the function, and/or the corresponding values of the range are received from a user (e.g., the physician) via a user interface 38 , which is included in visual output 37 .
  • a user e.g., the physician
  • FIG. 2 depicts user interface 38 taking the form of a color bar. By sliding two sliders 39 along the color bar, the user is able to choose the upper and lower limits, as well as the colors in which these limits are displayed.
  • the upper and lower limits are not received from a user, but rather, are calculated based on the distribution of ⁇ T. In yet other embodiments, the upper and lower limits are preset, constant values.
  • the lower limit of the domain is also the cutoff for identifying multiple-activation areas. For example, if the lower limit is 10 ms, areas having time differences of less than 10 ms may be treated as single-activation areas, despite these areas exhibiting multiple activations. In other embodiments, however, the cutoff may be different from the lower limit.
  • user interface 38 may allow the user to separately input a cutoff. Thus, for example, if the user inputs a cutoff of 5 ms, a lower limit of 10 ms, and an upper limit of 50 ms, assuming a black color for the lower limit and a white color for the upper limit:
  • Some multiple-activation areas may exhibit more than two local activation times.
  • the processor attempts to identify one or more of the local activation times as outliers, by, for example, comparing the local activation times to those of nearby areas. By disregarding any identified outliers, the number of local activation times is reduced. If more than two local activation times remain even after disregarding the outliers, the processor may, for example, calculate ⁇ T as the difference between the first and last local activation times. In other embodiments, the processor does not attempt to identify any outliers, but rather, simply calculates ⁇ T as the difference between the first and last local activation times, or uses any other suitable method to choose the “primary” two local activation times.
  • the processor ignores any portions of the intracardiac ECG that were recorded during portions of the cardiac cycle in which electrical noise is known to be relatively high. This may reduce the number of spurious local activations that are identified.
  • processor 28 further identifies at least one single-activation area, and displays, on map 32 , the single-activation area in a manner that indicates the single local activation time of the single-activation area. For example, in FIG. 2 , single-activation areas are identified for the majority of surface 34 , and these single-activation areas are displayed on the map in different colors (indicated in FIG. 2 by different dot-pattern densities), which indicate the different respective local activation times of the areas.
  • the processor applies a function that maps a domain of local activation times to a range of display-property values.
  • the processor may apply a function that maps a domain of local activation times T to a range of color values C1, which is distinct from the range of color values C2 in which the multiple-activation areas are displayed.
  • C2 may range between black and white, with C1 ranging across other colors such as blue, red, violet, etc. The use of distinct color-value ranges allows the physician to easily distinguish between multiple-activation areas and single-activation areas.
  • the upper and lower local-activation-time limits, and/or the range of display-property values for the single-activation areas is received via user interface 38 .
  • the user interface may include a separate color bar, and accompanying sliders, for setting the relevant values.
  • color interpolation may be used to assign color values to certain areas at which ECG recordings were not performed.
  • Such interpolation which may be performed in accordance with any relevant technique known in the art, typically gives the electroanatomical map a smooth appearance, thus allowing the electroanatomical map to be more readily interpreted.
  • first area is assigned a color value of (0,0,0,1)
  • second area is assigned a color value of (20,20,20,1)
  • areas that lie between the first and second areas may be assigned color values that increase (e.g., linearly) from (0,0,0,1) to (20,20,20,1).
  • the respective display-property values of the single-activation areas indicate to the physician the direction of electrical propagation, while the respective display-property values of the multiple-activation areas additionally indicate the location of any lines of block.
  • the physician may ascertain, based on the colors in which the single-activation areas are displayed, that the wavefront of electrical activity propagates outward from an area 40 of surface 34 , in all directions, including toward an area 42 of the surface.
  • the colors in which the multiple-activation areas are displayed further indicate that a line of block is located along the route from area 40 to area 42 , the edge of the line of block being at area 30 a.
  • the double-activation areas are displayed with indicative display-property values.
  • the double-activation areas may be displayed in the black-white color range, while the single-activation areas are displayed in a single color.
  • display 26 includes a legend that shows the mapping that was used to display the multiple-activation areas, and/or the mapping that was used to display the single-activation areas.
  • user interface 38 may include such a legend, in the form of the color bars described above.
  • FIG. 3 is a schematic illustration of visual output 58 a and 58 b , displayed in accordance with some embodiments of the present invention.
  • embodiments described herein may be used to locate a pathological line of block.
  • embodiments described herein may be used to identify an unintended gap in a line of ablation, which is a line of electrically non-conductive tissue created by a physician during an ablation procedure, typically in order to terminate or alter an arrhythmia of the subject.
  • Visual output 58 a corresponds to a scenario in which the line of ablation is continuous, as intended. In such a scenario, the varying colors of the multiple-activation areas provide intuitive, visual feedback to the physician that the ablation was successful.
  • Visual output 58 b corresponds to a scenario in which the line of ablation has an unintended gap 62 . In such a scenario, the varying colors of the multiple-activation areas provide intuitive, visual feedback to the physician that the ablation was not entirely successful. In response thereto, the physician may reablate the area at gap 62 .
  • FIG. 4 is a flow diagram for a method for displaying an electroanatomical map of an inner or epicardial surface of a heart, in accordance with some embodiments of the present invention.
  • an input-receiving step 46 receives user input, at an input-receiving step 46 .
  • such input includes the information that is used to map local-activation-time differences to display-property values for the multiple-activation areas, and/or the information that is used to map local activation times to display-property values for the single-activation areas.
  • the local activation times for a plurality of areas of the surface are measured, as described above. (In some embodiments, input-receiving step 46 is performed subsequently to measuring step 44 .)
  • each of the areas of the surface is identified as being either a single-activation area or a multiple-activation area.
  • a single-activation area is any area for which either (i) only one local activation time was measured, or (ii) the difference between local activation times is less than a cutoff.
  • the cutoff is typically the lower time-difference limit for the multiple-activation-area mapping. Thus, for example, if the user inputs a lower limit of 10 ms, any area for which the difference between local activation times is less than 10 ms will be classified as a single-activation area.
  • a first function which is based on the received user input, is used to map the local activation times of the single-activation areas to respective display-property values.
  • a second function which is also based on the received user input, is used to map the differences between local activation times of the multiple-activation areas to respective display-property values.
  • the electroanatomical map is then displayed, at a displaying step 54 , with the display-property values calculated in steps 50 and 52 . The physician may then use the electroanatomical map to diagnose the subject.
  • apparatus and methods described herein may be practiced with both static electroanatomical maps, which do not change from one heartbeat to the next, and dynamic electroanatomical maps.
  • dynamic electroanatomical maps may be used, for example, to visualize changes in the pattern of electrical propagation from one heartbeat to the next, in order to better diagnose and/or treat certain types of arrhythmias.

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IL248883A IL248883B (en) 2015-12-07 2016-11-09 Presentation of multi-activity areas in an electro-anatomical map
CA2949991A CA2949991A1 (fr) 2015-12-07 2016-11-28 Affichage de zones multi activation sur un plan electroanatomique
JP2016236505A JP6830805B2 (ja) 2015-12-07 2016-12-06 電気解剖学的マップ上における多重興奮到達区域の表示
EP16202441.8A EP3178391B1 (fr) 2015-12-07 2016-12-06 Affichage des zones à activation multiple sur une carte électroanatomique
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