US9416095B2 - Salts, crystals, complexes, and derivatives of threonine diacetic acid, a process to prepare threonine diacetic acid, and the use thereof - Google Patents
Salts, crystals, complexes, and derivatives of threonine diacetic acid, a process to prepare threonine diacetic acid, and the use thereof Download PDFInfo
- Publication number
- US9416095B2 US9416095B2 US14/905,432 US201414905432A US9416095B2 US 9416095 B2 US9416095 B2 US 9416095B2 US 201414905432 A US201414905432 A US 201414905432A US 9416095 B2 US9416095 B2 US 9416095B2
- Authority
- US
- United States
- Prior art keywords
- threonine
- salt
- diacetic acid
- acid
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 150000003839 salts Chemical class 0.000 title claims abstract description 36
- 239000013078 crystal Substances 0.000 title abstract description 9
- YGDANRKJYNQFFR-FBCQKBJTSA-N C[C@@H](O)[C@H](N(CC(O)=O)CC(O)=O)C(O)=O Chemical class C[C@@H](O)[C@H](N(CC(O)=O)CC(O)=O)C(O)=O YGDANRKJYNQFFR-FBCQKBJTSA-N 0.000 title description 12
- 239000000203 mixture Substances 0.000 claims abstract description 42
- 238000009472 formulation Methods 0.000 claims abstract description 4
- 239000004473 Threonine Substances 0.000 claims description 64
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 63
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 63
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 claims description 30
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 24
- 239000011734 sodium Substances 0.000 claims description 24
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 19
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 17
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 15
- -1 nitrile compound Chemical class 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- 229910052708 sodium Inorganic materials 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 13
- 229910052700 potassium Inorganic materials 0.000 claims description 13
- 239000011591 potassium Substances 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 10
- 150000001768 cations Chemical class 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229910052742 iron Inorganic materials 0.000 claims description 9
- 230000020477 pH reduction Effects 0.000 claims description 9
- 239000011575 calcium Substances 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 7
- 229910052791 calcium Inorganic materials 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 4
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 4
- 159000000000 sodium salts Chemical class 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- 229910052782 aluminium Inorganic materials 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 2
- 229910052792 caesium Inorganic materials 0.000 claims description 2
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims description 2
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 229910052744 lithium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
- 239000004411 aluminium Substances 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 32
- 239000006185 dispersion Substances 0.000 abstract description 3
- 239000002002 slurry Substances 0.000 abstract description 2
- 229960002898 threonine Drugs 0.000 description 61
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 60
- 230000015572 biosynthetic process Effects 0.000 description 24
- 239000002738 chelating agent Substances 0.000 description 17
- 239000000047 product Substances 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 12
- 239000007787 solid Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 229910052783 alkali metal Inorganic materials 0.000 description 8
- 239000003599 detergent Substances 0.000 description 8
- 230000014759 maintenance of location Effects 0.000 description 8
- 150000002825 nitriles Chemical class 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 238000005481 NMR spectroscopy Methods 0.000 description 7
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 7
- 230000002378 acidificating effect Effects 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 6
- 229910021529 ammonia Inorganic materials 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000005160 1H NMR spectroscopy Methods 0.000 description 5
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 5
- 238000009616 inductively coupled plasma Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 4
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 238000001704 evaporation Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000003456 ion exchange resin Substances 0.000 description 4
- 229920003303 ion-exchange polymer Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 4
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 3
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 3
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 238000004061 bleaching Methods 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 239000013522 chelant Substances 0.000 description 3
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000008098 formaldehyde solution Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 3
- CSIFGMFVGDBOQC-UHFFFAOYSA-N 3-iminobutanenitrile Chemical compound CC(=N)CC#N CSIFGMFVGDBOQC-UHFFFAOYSA-N 0.000 description 2
- BDKQUSBWXQKOGS-FBCQKBJTSA-N C[C@H]1OC(=O)CN(CC(O)=O)[C@@H]1C(O)=O Chemical compound C[C@H]1OC(=O)CN(CC(O)=O)[C@@H]1C(O)=O BDKQUSBWXQKOGS-FBCQKBJTSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003518 caustics Substances 0.000 description 2
- 229920001429 chelating resin Polymers 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- LTYRAPJYLUPLCI-UHFFFAOYSA-N glycolonitrile Chemical compound OCC#N LTYRAPJYLUPLCI-UHFFFAOYSA-N 0.000 description 2
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- 150000004679 hydroxides Chemical class 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000011785 micronutrient Substances 0.000 description 2
- 235000013369 micronutrients Nutrition 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 2
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 2
- 238000003918 potentiometric titration Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000006798 ring closing metathesis reaction Methods 0.000 description 2
- FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 2
- 239000012265 solid product Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- IVWWFWFVSWOTLP-YVZVNANGSA-N (3'as,4r,7'as)-2,2,2',2'-tetramethylspiro[1,3-dioxolane-4,6'-4,7a-dihydro-3ah-[1,3]dioxolo[4,5-c]pyran]-7'-one Chemical compound C([C@@H]1OC(O[C@@H]1C1=O)(C)C)O[C@]21COC(C)(C)O2 IVWWFWFVSWOTLP-YVZVNANGSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- BDKQUSBWXQKOGS-UHFFFAOYSA-N CC1OC(=O)CN(CC(O)=O)C1C(O)=O Chemical compound CC1OC(=O)CN(CC(O)=O)C1C(O)=O BDKQUSBWXQKOGS-UHFFFAOYSA-N 0.000 description 1
- HQDWLFZDKXCJRB-WYAAXJSCSA-N C[C@H]1OC(=O)CN(CC(=O)O)[C@@H]1C(=O)O.O.O=C=O.[H]CN(CC(=O)O)[C@H](C(=O)O)[C@@H](C)O.[OH3+] Chemical compound C[C@H]1OC(=O)CN(CC(=O)O)[C@@H]1C(=O)O.O.O=C=O.[H]CN(CC(=O)O)[C@H](C(=O)O)[C@@H](C)O.[OH3+] HQDWLFZDKXCJRB-WYAAXJSCSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- IYBCYJZKZFSOGW-BYPYZUCNSA-N OC(=O)CN1CC(=O)OC[C@H]1C(O)=O Chemical compound OC(=O)CN1CC(=O)OC[C@H]1C(O)=O IYBCYJZKZFSOGW-BYPYZUCNSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- NSIKFNOYIGGILA-UHFFFAOYSA-N [Na].[Na].[K] Chemical compound [Na].[Na].[K] NSIKFNOYIGGILA-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical compound NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 description 1
- 150000008361 aminoacetonitriles Chemical class 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- KDPAWGWELVVRCH-UHFFFAOYSA-N bromoacetic acid Chemical compound OC(=O)CBr KDPAWGWELVVRCH-UHFFFAOYSA-N 0.000 description 1
- LLSDKQJKOVVTOJ-UHFFFAOYSA-L calcium chloride dihydrate Chemical compound O.O.[Cl-].[Cl-].[Ca+2] LLSDKQJKOVVTOJ-UHFFFAOYSA-L 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 150000005323 carbonate salts Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229910001914 chlorine tetroxide Inorganic materials 0.000 description 1
- 150000001868 cobalt Chemical class 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- KVPZWVBHVFPEEG-FHNDMYTFSA-L disodium 2-[[(1S)-1-carboxy-2-hydroxyethyl]-(carboxylatomethyl)amino]acetate Chemical compound C(CN([C@@H](CO)C(=O)O)CC(=O)[O-])(=O)[O-].[Na+].[Na+] KVPZWVBHVFPEEG-FHNDMYTFSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000909 electrodialysis Methods 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000004698 iron complex Chemical class 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000010641 nitrile hydrolysis reaction Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000005324 oxide salts Chemical class 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Chemical compound [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 description 1
- 150000003588 threonines Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229910009112 xH2O Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/25—Aminoacetonitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
Definitions
- the present invention relates to new salts, crystals, complexes, and derivatives of the chelating agent threonine-N,N-diacetic acid, to processes to prepare such threonine diacetic acid and its salts, complexes, crystals, and derivatives, and to the use thereof.
- the detergent market is currently undergoing important changes. Due to ecological and regulatory reasons the use of phosphate in high concentrations in detergent formulations is to be banned altogether or must at least be greatly reduced.
- the formulators of detergent products have to find alternatives to replace the phosphate compounds, with the most promising replacements being biodegradable chelating agents. In other areas where acids are used, there is a growing trend towards replacing acids with more eco-friendly materials. In the oil industry operators are also looking for alternatives, and here again biodegradable chelating agents that can be isolated in their acidic form proved to be promising alternatives.
- chelating agent is serine-N,N-diacetic acid.
- U.S. Pat. No. 5,019,296 discloses the use thereof in detergents as complexing agent, bleaching agent stabilizer and builder.
- the chelating agent should be obtainable in good yield by a simple process with little or no colour.
- U.S. Pat. No. 5,019,296 discloses a preparation of serine-N,N-diacetic acid by reacting formaldehyde and hydrogen cyanide with serine and S Korman et al., Journal of Biological Chemistry, Vol. 22, no. 18, 1 Jan. 1956, pp. 113-132 discloses a preparation of serine diacetic acid by reacting serine with monobromo acetic acid, which is from an industrial perspective a less attractive route because of lower yields and expensive raw materials.
- the present invention now provides processes to prepare threonine N,N-diacetic acid and salts or complexes thereof, provides salts of threonine N,N-diacetic acid of the formula CH 3 —CHOH—C(H)(COOM)-N—(CH 2 —COOM) 2 , wherein at least one M is sodium, potassium, lithium, cesium, ammonium, and provides complexes of threonine diacetic acid and a divalent or trivalent cation, wherein the cation is selected from the group of calcium, magnesium, iron, zinc, manganese, aluminum, copper, and cobalt.
- the present invention covers each of the above products in which the amount of the L-enantiomer (i.e. the 2S, 3R threonine enantiomer; the natural amino acid based enantiomer) is at least 50 mole %, as well as crystals of any of the above products and liquids containing one or more of the above products and a solvent, and dispersions thereof containing a continuous liquid phase.
- the amount of the L-enantiomer i.e. the 2S, 3R threonine enantiomer; the natural amino acid based enantiomer
- threonine-N,N-diacetic acid is mentioned together with for example the above discussed serine-N,N-diacetic acid, which is, as said, a chelating agent having a not too different chemical structure.
- the present invention provides processes to prepare threonine N,N-diacetic acid.
- the processes of the invention do give the much less coloured to non-coloured chelating agent threonine N,N-diacetic acid and salts thereof, from which also low coloured complexes can be prepared, though it should be realized that some complexes are intrinsically coloured due to the choice of cation, e.g. iron, copper, manganese and cobalt complexes are oftentimes coloured.
- the processes of the invention to prepare threonine N,N-diacetic acid are a process comprising two or more steps wherein in one step threonine, a sodium or potassium salt thereof or a mixture thereof is reacted with formaldehyde and hydrogen cyanide, at a pH equal to or below 7, and in another step the nitrile compound formed in the first step is hydrolyzed in the presence of a base, or less preferably in the presence of an acid (a Singer process); a process comprising reacting threonine, a sodium or potassium salt thereof or a mixture thereof with formaldehyde, hydrogen cyanide, a potassium or sodium salt thereof or a mixture thereof, and potassium hydroxide, sodium hydroxide or a mixture thereof, in an aqueous solution, at a pH higher than 7 and at an elevated temperature to remove formed NH 3 (a Strecker/Bersworth process); and a process wherein threonine is reacted with a monohaloacetic acid (CH2X—CO
- the invention in addition relates to the molecule 4-(carboxymethyl)-2-methyl-6-oxomorpholine-3-carboxylic acid, which is basically the molecule of threonine N,N-diacetic acid having undergone a ring closure reaction.
- This ring closure takes place after subjecting threonine-N,N-diacetic acid to conditions under which water is easily extracted, which are often acidic conditions, such as adding an acid, an ion exchange resin or subjecting the molecule to acidifying electrodialysis, but also increasing the temperature or reducing the pressure, as represented in the scheme below.
- threonine-N,N-diacetic acid is capable of ring closing as indicated above makes it a chelating agent with delayed functionality, which is an advantage in many applications where the chelating capacity should take place slowly and not instantaneously, such as the use of the compound in the oil or gas field. It should be noted that threonine N,N-diacetic acid much easier and more completely undergoes the ring closure than serine-N,N-diacetic acid, which is the most similar molecule from a chemical structure perspective, which is another benefit for the products of the present invention.
- threonine-N,N-diacetic acid can be produced in high yields, forms relatively stable complexes with many cations (to phrase it differently, it is one of the stronger chelating agents within the group of chelating agents that do not bind cations so strongly that they will hardly release them again). Further, the compound is readily biodegradable.
- THDA threonine-N,N-diacetic acid
- alkali metal salts wherein y is more than 1 strike a good balance between low viscosity and being obtainable by a process using raw materials that are easily available on an industrial site for a low price. Also, these alkali metal salts have a reasonable molecular weight to viscosity balance, i.e. they have a sufficiently low viscosity to make them transportable and a sufficiently low molecular weight to get sufficient chelate activity per weight unit of alkalimetal chelate salt.
- mixed salts of THDA have the benefit that they can be transported in high concentrations (60% expressed in wt % is no problem) while still having a sufficiently low viscosity to be pumpable at low temperatures ( ⁇ 40° C.). This also means that a smaller amount of material needs to be transported to get the same amount of chelate at the place of destination.
- the mixed salt is lower than for a full potassium version for solutions having the same chelating power.
- the molecular weight of the trisodium salt of THDA being 301.1, would become 349.5 for the tripotassium salt. So, to get the same active ingredient with respect to sequestering power almost 20% more material would need to be dissolved.
- the monopotassium disodium THDA of the invention requires only 5% more product to be dissolved instead of 20%, and this without the product having the negative effect of high viscosity at more concentrated solutions when compared with the trisodium version.
- x is between 1.5 and 2.5 and y is between 0.5 and 1.5, most preferably x is about 2 and y is about 1.
- the invention provides a process to prepare the above (alkali metal salts of) threonine-N,N-diacetic acid (THDA) comprising reacting threonine, a sodium or potassium salt thereof or a mixture thereof, with formaldehyde, hydrogen cyanide, a potassium or sodium salt thereof or a mixture thereof, and potassium hydroxide, sodium hydroxide or a mixture thereof, in an aqueous solution at an elevated temperature to remove formed NH 3 .
- THDA threonine-N,N-diacetic acid
- the molar ratio of sodium to potassium in the reactants is between 1:1 and 5:1.
- the molar ratio of sodium to potassium in the reactants is between 1:1 and 3:1, most preferably about 2:1.
- the novel threonine-N,N-diacetic acid salt is prepared by a so-called Strecker/Bersworth route at alkaline conditions using an 1-pot synthesis.
- the reaction route encompasses reacting threonine with formaldehyde and hydrogen cyanide in the presence of sodium hydroxide and potassium hydroxide.
- the excess cyanide/formaldehyde needed is 10% or more; use is made of a minimum of 2.2 equivalents cyanide/formaldehyde per equivalent of threonine.
- glycolonitrile HO—CH 2 —CN
- This glycolonitrile is reacted with threonine or the sodium or potassium salt thereof in an alkaline environment (Strecker/Bersworth process). 1 threonine+2HO—CH 2 —CN+3MOH ⁇ THDA-M 3 +2NH 3 +2H 2 O
- the threonine diacetic acid and its (alkali metal) salts of the invention are prepared by a Singer process comprising two or more steps, wherein in a first step threonine, a sodium or potassium salt thereof or a mixture thereof is reacted with formaldehyde and hydrogen cyanide at a pH equal to or below 7, and in a subsequent step the nitrile compound formed in the first step is hydrolyzed with an alkali metal hydroxide, and optionally acidified in a next step.
- the acidification step can be performed by adding an organic or inorganic acid, but is preferably done, mainly to avoid the formation of salt, by reaction with an ion exchange resin or by an electrodialytical acidification, such as for example disclosed in EP-A-1004571 or EP-A-2086923.
- a mixture of alkali metal hydroxides can be used, for example one wherein the molar ratio of sodium to potassium in the reactants is between 1:1 and 5:1.
- a two-step process in which the first step takes place at neutral or acidic pH (the above so-called Singer process), between 1.6 and 2.4 equivalents of formaldehyde are used per equivalent of threonine or salt thereof and 1.6 to 2.4 equivalents of HCN are used per equivalent of threonine or salt thereof.
- 1.9-2.1 equivalents of formaldehyde and HCN are used per equivalent of threonine or salt thereof.
- the amount of formaldehyde and HCN is about 2.0 equivalents per equivalent of threonine or salt thereof.
- the amount of HCN may be (but does not need to be) the same as the amount of formaldehyde.
- the first step is split up into two substeps, firstly a reaction of threonine or its salt with formaldehyde to generate a Schiff base intermediate and subsequently a reaction with HCN and remaining formaldehyde to form threonine N,N diacetonitrile.
- the raw material is monosodium salt of threonine, threonine or the monopotassium salt of threonine.
- the solubility of threonine can be enhanced by dissolving it in MOH (resulting in the formation of monosodium or monopotassium salt); having about 0.6-1.4 equivalents of base is preferred.
- the monosodium salt or monopotassium salt of threonine is then dissolved in water and formaldehyde and cyanide are added to obtain final reaction mixture with acidic or neutral pH.
- the addition of formaldehyde and hydrogen cyanide preferably takes place at a temperature between 0 and 70° C., preferably 0 and 40° C.
- the result is an intermediate product having two nitrile functionalities.
- These types of products are known as aminoacetonitriles or, for short, “nitriles”.
- the nitrile of THDA e.g. threonine-N,N-diacetonitrile, is also indicated as THDN below.
- the nitrile, being a water-soluble compound, is hydrolyzed in a second step applying caustic.
- each M and M′ may be the same or different and represent an alkali metal ion.
- the process has as an additional benefit that having potassium THDN one needs only sodium hydroxide to produce the THDA-KNa2. Not all production locations have access to KOH or storage tanks of KOH; NaOH is more commonly used. Production of a mixed salt is easier than of the full potassium version that requires KOH to be present in each location, i.e. the location carrying out the nitrile hydrolysis only needs the commonly used NaOH.
- threonine diacetonitrile monopotassium salt is formed by reacting either potassium salt of threonine with hydrogen cyanide and formaldehyde or threonine with potassium cyanide and formaldehyde, the nitrile being hydrolyzed with sodium hydroxide in the subsequent step.
- threonine As starting material instead of threonine also the potassium salt thereof can be employed.
- the main advantage of monopotassium salt of threonine in the production process is its very high solubility even at room temperature.
- Monosodium threonine has a high solubility in water at room temperature (higher solubility compared to the non-salt threonine itself), monopotassium threonine has an even higher solubility.
- the more concentrated the threonine can be processed the less water removal is required to make a concentrated THDA solution.
- the final nitrile concentration will be higher due to the higher solubility of potassium salt of threonine. It allows for more economical transport, more output per reactor volume, lower energy costs, and is an easy way to produce highly concentrated final THDA solutions in the hydrolysis of the nitrile functionalities without water removal.
- the invention provides the following two alternative processes. Firstly, a process comprising titrating threonine-N,N-diacetic acid (or an appropriate derivative or salt thereof) with a sodium salt and a potassium salt wherein the molar ratio of sodium to potassium in the materials is between 5:1 and 1:1 and, secondly, a process of mixing the trisodium salt of THDA and the tripotassium salt of THDA in a molar ratio of between 5:1 and 1:1.
- the complexes of the present invention are made by contacting a salt of threonine diacetic acid or the acidic version of threonine diacetic acid with a compound containing a divalent or trivalent metal cation, like a salt of such a metal cation, preferably, the carbonate, oxide or hydroxide salt of such cation to avoid the formation of further salts, even more preferably the oxide salt, as hydroxide salts sometimes are not too soluble and the use of carbonate salts may result in the formation of a considerable amount of CO 2 gas, which is sometimes undesirable.
- a metal oxide it is preferred to use the threonine N—N-diacetic acid in the acidic version.
- the complexes are normally made in a solvent, preferably water.
- ammonium salts of the present invention are preferably made by contacting the acidic version of threonine diacetic acid (i.e. wherein at least one of the counterions is a hydrogen ion) with an ammonium salt or ammonia, preferably with NH 4 OH.
- the present invention relates to the use of the alkali metal salts in a detergent or bleaching composition, a descaling composition, a microbial composition, human food or animal feed composition, an oil or gas well treatment composition, a micronutrient composition, in gas sweetening, pulp and paper bleaching, drilling, or in the preparation of any of such compositions.
- a 1 liter reactor was charged with 178.5 g threonine, (1.5 moles), 300 g water, and 130 g 50 wt % aqueous NaOH (1.6 moles). The reactor contents were heated to boiling temperature. Simultaneously in circa 3 hours 4.0 moles sodium cyanide solution (30 wt %) and 4.0 moles formaldehyde solution (44 wt %) were dosed. After the dosing was completed 2 hrs of boiling off ammonia/water took place (level control of the mixture by addition of water).
- Circa 995 grams of a light-coloured solution having a Fe-sequestering capacity of 48 wt % were obtained, which contained ⁇ 1 wt % of the starting material, threonine, indicating a good conversion.
- a 1 liter reactor equipped with a stirrer, thermometer, and pH meter was charged with 104 g threonine (0.87 moles), 500 g water, and 5.5 grams 50 wt % aqueous NaOH. To this solution 67 g 44.3% formaldehyde solution (0.99 moles) were added. Subsequently over a period of 80 minutes, 54 g HCN (2.00) moles and 67 g (0.99 moles) 44.3 wt % formaldehyde were co-dosed. The pH was adjusted to 4 with 50% sodium hydroxide. The threonine diacetonitrile solution was dosed over a period of 90 minutes to a reactor that contained 209 g 50% caustic and 250 g water. After dosing had been completed the ammonia was boiled off by evaporating water/ammonia at 109° C. using level control by addition of water. The reactor mixture (650 grams) showed a Fe-sequestering capacity of 28%.
- a 3 liter jacketed reactor with baffles and turbine stirrer was charged with 858 g of water and 361.0 g (3 moles) of L-threonine (99%, Fluka). This slurry is heated to 60° C. The dosing of 50 wt % aqueous NaOH solution was started and the pH value was maintained at 8.0 during the process when dosing a 42.9 wt % aqueous solution of sodium monochloroacetate. The reaction was monitored by the determination of its sequestering value.
- the solution obtained in example 1 was acidified using an ion exchange resin. Acidification took place using Amberlite IR-120, a strong acid ion exchange resin: 55 g of GLDA solution, 110 g of Amberlite IR-120 as such, and ca 100 g of water were stirred in a 500 ml round-bottomed flask for at least 48 h. After filtering off the resin the solution was dried by evaporation of water at reduced pressure at 70° C. The light-coloured crispy foam obtained was further dried in a vacuum oven at 65° C. This resulted in a solid product in a yield of circa 85%.
- the ratio of open/closed structure in solution is dependent on a number of factors such as e.g. pH-value, concentration.
- the ratio of open/closed structure in solid form strongly depends on factors like e.g. drying time, temperature, strength of vacuum applied.
- Example 2 Water was removed from 50.8 g of the solution of Example 1 using a rotavap at 65° C. under reduced pressure. This resulted in 39.41 g of solid material. After dissolving this solid in glacial acetic acid (100 ml) the solution was precipitated by mixing with about 1,200 ml of isopropyl alcohol (IPA). After filtration through a G2 filter frit the solid was dried in a vacuum oven under reduced pressure at 100° C., resulting in 15.49 g of colourless material with a THDA:THDA ring closed ratio of 80:20
- IPA isopropyl alcohol
- Example 1 The solution obtained in Example 1 was used to prepare the powder of threonine diacetate.
- To the obtained mixture an equimolar amount of an aqueous solution of CaCl 2 .2H 2 O was added, followed by partial evaporation under vacuum to give a concentrated mixture.
- the concentrated mixture was left standing overnight at room temperature for further crystallization.
- the obtained solids were filtered off, washed with water (3 ⁇ 1 ml), and dried under vacuum (50° C.) to obtain white crystals.
- the formation of the crystalline Ca-THDA complex was supported by XRD, ICP, ESI-MS, and NMR analysis of the isolated material.
- Example 2 Following the procedure as in Example 1, a 1 liter reactor was charged with 157.6 g serine, (1.5 moles), 120 g water, and 123 g 50 wt % aqueous NaOH (1.54 moles). The reactor contents were heated to boiling temperature. Simultaneously in circa 3 hours 4.0 moles sodium cyanide solution (30 wt %) and 4.0 moles formaldehyde solution (44 wt %) were dosed. After the dosing was completed 2 hrs of boiling off ammonia/water took place (level control of the mixture by addition of water). Ca.
- a 30% aqueous solution of disodium threonine diacetate (129 mg) was mixed well with a DMSO-d 6 /TFA solution (2761 mg, 80:20 w/w) and changes in the obtained mixture were monitored by 1 H NMR at ambient temperature. The steady state was reached after 40 minutes with a conversion of 90% of THDA to cyclic-THDA.
- THDA can be used in applications that relate to dissolving carbonate or sequestering iron, such as use in the oil field (e.g. dissolving CaCO 3 and controlling iron in subterranean treatment), use in a feed, food or micronutrient composition (e.g. complexing iron and calcium for delivery to growing substrates), use in detergents and water treatments (e.g. sequestering calcium from water to soften water and sequestering iron present in stains), and many more uses.
- oil field e.g. dissolving CaCO 3 and controlling iron in subterranean treatment
- use in a feed, food or micronutrient composition e.g. complexing iron and calcium for delivery to growing substrates
- use in detergents and water treatments e.g. sequestering calcium from water to soften water and sequestering iron present in stains
Abstract
Description
1 threonine+2HO—CH2—CN+3MOH→THDA-M3+2NH3+2H2O
1 threonine+2CH2O+2HCN+3MOH→THDA-M3+2NH3+H2O
CH3—CHOH—C(H)(COOM′)-N—(CH2—CN)2+2M(OH)+2H2O→CH3—CHOH—C(H)(COOM′)-N—(CH2—COOM)2+2NH3
(aminoacetonitrile intermediate+base→aminocarboxylate+ammonia)
Claims (12)
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Also Published As
Publication number | Publication date |
---|---|
CN105377809A (en) | 2016-03-02 |
CA2917252A1 (en) | 2015-01-22 |
CN105377809B (en) | 2018-06-08 |
US20160159730A1 (en) | 2016-06-09 |
WO2015007630A1 (en) | 2015-01-22 |
EP3022171B1 (en) | 2017-07-05 |
EP3022171A1 (en) | 2016-05-25 |
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