US9106046B2 - Integrated optical structure comprising an optical isolator - Google Patents
Integrated optical structure comprising an optical isolator Download PDFInfo
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- US9106046B2 US9106046B2 US14/349,394 US201214349394A US9106046B2 US 9106046 B2 US9106046 B2 US 9106046B2 US 201214349394 A US201214349394 A US 201214349394A US 9106046 B2 US9106046 B2 US 9106046B2
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Images
Classifications
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/005—Optical components external to the laser cavity, specially adapted therefor, e.g. for homogenisation or merging of the beams or for manipulating laser pulses, e.g. pulse shaping
- H01S5/0064—Anti-reflection components, e.g. optical isolators
-
- G—PHYSICS
- G02—OPTICS
- G02F—OPTICAL DEVICES OR ARRANGEMENTS FOR THE CONTROL OF LIGHT BY MODIFICATION OF THE OPTICAL PROPERTIES OF THE MEDIA OF THE ELEMENTS INVOLVED THEREIN; NON-LINEAR OPTICS; FREQUENCY-CHANGING OF LIGHT; OPTICAL LOGIC ELEMENTS; OPTICAL ANALOGUE/DIGITAL CONVERTERS
- G02F1/00—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics
- G02F1/01—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour
- G02F1/09—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on magneto-optical elements, e.g. exhibiting Faraday effect
- G02F1/095—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on magneto-optical elements, e.g. exhibiting Faraday effect in an optical waveguide structure
- G02F1/0955—Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulating; Non-linear optics for the control of the intensity, phase, polarisation or colour based on magneto-optical elements, e.g. exhibiting Faraday effect in an optical waveguide structure used as non-reciprocal devices, e.g. optical isolators, circulators
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/50—Amplifier structures not provided for in groups H01S5/02 - H01S5/30
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B2006/12083—Constructional arrangements
- G02B2006/12085—Integrated
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
- G02B6/12—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
- G02B2006/12133—Functions
- G02B2006/12157—Isolator
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/02—Structural details or components not essential to laser action
- H01S5/0206—Substrates, e.g. growth, shape, material, removal or bonding
- H01S5/021—Silicon based substrates
-
- H01S5/02248—
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/02—Structural details or components not essential to laser action
- H01S5/022—Mountings; Housings
- H01S5/023—Mount members, e.g. sub-mount members
- H01S5/02325—Mechanically integrated components on mount members or optical micro-benches
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/02—Structural details or components not essential to laser action
- H01S5/026—Monolithically integrated components, e.g. waveguides, monitoring photo-detectors, drivers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01S—DEVICES USING THE PROCESS OF LIGHT AMPLIFICATION BY STIMULATED EMISSION OF RADIATION [LASER] TO AMPLIFY OR GENERATE LIGHT; DEVICES USING STIMULATED EMISSION OF ELECTROMAGNETIC RADIATION IN WAVE RANGES OTHER THAN OPTICAL
- H01S5/00—Semiconductor lasers
- H01S5/10—Construction or shape of the optical resonator, e.g. extended or external cavity, coupled cavities, bent-guide, varying width, thickness or composition of the active region
- H01S5/1003—Waveguide having a modified shape along the axis, e.g. branched, curved, tapered, voids
- H01S5/1014—Tapered waveguide, e.g. spotsize converter
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/755—Nanosheet or quantum barrier/well, i.e. layer structure having one dimension or thickness of 100 nm or less
Definitions
- the present invention pertains to an optical isolator intended to be integrated into optical devices, such as optoelectronic components, and, in particular, photonic integrated circuits, or PICs. These optical devices are used mainly in the field of high-speed digital telecommunications.
- the invention also extends to the method for manufacturing such an optical isolator.
- optical isolator is a nonreciprocal passive device that has high attenuation in one direction and low attenuation in the opposite direction; it makes it possible to transmit light in only one direction, but prevents light from propagating in an opposite direction. For this reason, optical isolators are essential elements for eliminating the negative effects of reflected and parasitic light beams in fiber-optic transmission, particularly at high speeds.
- integrated component refers to a component that is monolithically incorporated into a device, meaning a component supported by a substrate that is shared with the device's components.
- a first type of optical isolator implements a nonreciprocal optical effect so that it can serve as an optical isolator, the most well-known of which is the Faraday effect.
- magneto-optical materials change the light's polarization direction.
- An optical isolator of this first type is normally composed of (i) a magnetic garnet crystal that has a Faraday effect, (ii) a permanent magnet for applying a defined magnetic field, and (iii) polarizing elements that allow only light that has a given direction of polarization (incident light) to pass through, while blocking the passage of light that has a direction of polarization orthogonal to that of the incident light.
- This first type of optical isolator is hard to integrate into optical devices, as it requires multiple components whose integrated version is not yet available.
- optical isolator an absorption optical isolator, whose complex optical index is nonreciprocal.
- the optical index of some ferromagnetic materials such as an iron-cobalt metal alloy, depends on the direction in which the light propagates. Depending on its direction of propagation, the light will consequently be more attenuated or less.
- This second type of optical isolator is well suited to being integrated into optical devices that particularly comprise a semiconductor laser source.
- the ferromagnetic metals introduce high optical power losses, often greater than 20 dB, including in the incident direction.
- Semiconductor optical amplifiers, or SOAs must therefore also be integrated in order to compensate for these optical power losses.
- SOAs Semiconductor optical amplifiers
- the amplification of the optical signal provided by the SOA makes it possible to offset the ferromagnetic material's optical power losses in a first direction of incident light propagation. In the direction opposite the propagation, the ferromagnetic material's attenuation remains predominant, in order to keep the light from traveling backwards.
- optical isolator of this second type normally comprises an optical amplifier SOA made up of a stack (i) of an n-doped semiconductor material layer, (ii) an amplifying active part, which has an optical index greater than the layers that surround it, and (iii) a p-doped semiconductor material layer.
- the ferromagnetic metals may be deposited onto the top or sides of the SOA's waveguide.
- the strip's height is very critical, as the optical signal's propagation mode needs to interact with the ferromagnetic metals. This is because the waveguide's thickness determines the distance separating the ferromagnetic metals from the amplifying active layer. In this case, there will be considerable optical power losses due both to the electrical contact layers, often made of an InGaAs, ternary semiconducting material, and to the electrical contact-conveying metallic layer, which is placed above the waveguide.
- the ferromagnetic metal layer depositing operation is the very critical operation.
- the step of removing material by etching turns out to be very difficult to carry out in this type of optical isolator.
- the purpose of the present invention is to disclose an integrated optical structure comprising an optical isolator of the second type that does not exhibit the drawbacks of optical isolators of this type known from the prior art.
- the object of the present invention is an integrated optical structure comprising
- the optical isolator's integrated optical structure uses the hybrid technology of integrating III-V semiconducting materials on a silicon-based substrate, called “III-V on SOI” (for “Silicon On Isolator”).
- III-V on SOI for “Silicon On Isolator”.
- the magneto-optical layer is now disposed beneath the waveguide's active zone.
- the optical isolator's magneto-optical layer is a layer of ferromagnetic metallic material.
- Ferromagnetic materials include iron, cobalt, nickel, Fe-based alloys (particularly ferrites) and/or Co, and HEUSLER alloys with the formula X 2 YZ, such as Cu 2 MnAl, Cu 2 MnIn, Cu 2 MnSn, etc . . .
- the optical isolator's magneto-optical layer is a metallic alloy layer with the equiatomic composition Fe 50 Co 50 .
- the optical isolator's magneto-optical layer is a magnetic oxide layer (garnets, perovskite, etc.).
- the upper insulating layer and the lower insulating layer are made up of an insulating material chosen from between a silicon nitride SiN and a silicon oxide SiO x .
- the n-doped semiconductor layer and p-doped semiconductor layer of the waveguide are made of a semiconducting material of the III-V group, particularly indium phosphide InP or gallium arsenide GaAs.
- the active area of the waveguide comprises a structure with multiple quantum wells.
- the method comprises the following steps:
- the magneto-optical layer is deposited by a cathodic spraying method.
- the magneto-optical layer is etched in order to give it a structure that makes it possible to increase the magneto-optical effect.
- the method comprises at least one operation intended to smooth the surface of a layer of insulating material using a CMP method.
- the present invention has several advantages, including:
- the invention is intended to be used by optoelectronic component manufacturers, particularly PIC photonic integrated circuits.
- FIG. 1 depicts a lateral perspective view of one embodiment of an integrated optical structure comprising an optical isolator
- FIGS. 2 a and 2 b depict a view, respectively from the top and side, of another embodiment of an integrated optical structure comprising an optical isolator,
- FIG. 3 schematically depicts the method of creating an integrated optical structure comprising an optical isolator.
- FIG. 1 depicts an integrated optical structure comprising an optical isolator created by the hybrid technology III-V on SOI.
- the SOI technology consists of inserting an electrically insulating layer of a silicon oxide SiO x , such as SiO 2 , between a semiconducting thin upper layer of silicon Si and a semiconducting thick lower layer of silicon Si, with the assembly constituting a SOI base.
- the optical isolator 1 is integrated onto a SOI base 2 that comprises a crystalline silicon Si layer 3 , or any other semiconducting substrate, covered by an insulating layer 4 , for example one made of a silicon oxide SiO x like silica SiO 2 , topped with a second crystalline silicon Si layer 5 .
- the thickness of the silicon layers is at most 0.5 ⁇ m and that of the silicon oxide layer is about 2 ⁇ m.
- the optical isolator 1 is associated with an optical waveguide 6 made of a stack of a semiconducting lower n-doped III-V layer 7 , for example an indium phosphide InP based one, an active area 8 , and a semiconducting upper p-doped III-V layer 9 , for example also an indium phosphide InP based one.
- the semiconducting material III-V may particularly be an indium phosphide InP or a gallium arsenide GaAs.
- the active area 8 comprises, for example, an MQW (“Multiple Quantum Wells”) structure.
- the SOA 10 comprises the waveguide 6 with a semiconducting multilayer structure, topped with an upper electrical contact layer 11 , for example made of an InGaAs ternary semiconducting material.
- the upper electrical contact layer 11 is itself coated with a metallic film 12 that makes it possible to inject current through the metallic contact into the active layer of the SOA amplifying semiconducting structure.
- the lower semiconducting layer 7 plays the role of a lower electrical contact layer for the SOA optical amplifier 10 .
- a metallic layer 13 may then be affixed onto the lower semiconducting layer 7 to allow the current to continue. The optical losses may thereby be compensated by injecting electrical current into a SOA semiconductor optical amplifier structure with multiple quantum wells.
- the optical isolator 1 comprises an upper insulating layer 14 and a lower insulating layer 15 , for example one made of a silicon nitride Si x N y like Si 3 N 4 , or a silicon oxide SiO x .
- the insulating layer is made of SiO 2 .
- a magneto-optical layer 16 of ferromagnetic metals is sandwiched between the upper insulating layer 14 and the lower insulating layer 15 .
- the magneto-optical layer 16 comprises, for example, ferromagnetic metals, such as an iron-cobalt [Fe:Co] metal alloy, the atomic percentage of iron being comprised between 50% and 90%, and preferably the metal alloy is an equiatomic composition Fe 50 Co 50 .
- the magneto-optical layer 16 creates an attenuation of the light wave 17 propagating within the optical waveguide 6 .
- the ferromagnetic, metallic magneto-optical layer 16 is magnetized perpendicular to the direction in which the optical signal propagates.
- the magneto-optical layer 16 is constructed here by a method comprising steps of depositing followed by steps of etching, so as to let the magneto-optical layer 16 made of a ferromagnetic metallic alloy [Fe:Co] occupy a determined surface.
- the SOA optical amplifier 10 comprising the waveguide 6 with III-V semiconductors makes it possible to obtain optical amplification, while the ferromagnetic metals 16 introduce a refraction index or non-reciprocal losses in order to serve as an optical isolator.
- the waveguide's width may vary from 0.5 ⁇ m to 2 ⁇ m, for example.
- the magneto-optical layer 16 for example a ferromagnetic metallic alloy [Fe:Co] preferably has a thickness between 30 nm and 150 nm, and the upper 14 and lower 15 insulating layers, for example made of silica SiO 2 , placed above and in contact with the magneto-optical layer 16 , have a thickness of about 30 nm.
- the optical waveguide 6 based on III-V semiconductors here has a typical layered structure that allows coupling between the III-V semiconductors and the optical isolator 1 integrated onto a base 2 constructed using the SOI technique.
- TM mode for “Transverse Magnetic”, a mode for which the losses and the refraction index of ferromagnetic metals are non-reciprocal
- metallic magneto-optical layer 16 with more than 0.5% of the mode confinement factor in the magneto-optical layer 16
- Such a structure comprises two extreme regions 20 A and 20 B of the amplifier, in which the III-V waveguide typically has a width of 2 ⁇ m.
- the structure also comprises a central isolator region 21 whose width is about 0.5 ⁇ m.
- the structure finally comprises two intermediary regions 22 A and 22 B in which two cones enable the transition between the isolator and amplifier regions.
- the optical mode propagates within the SOA optical amplifier without interacting with the optical isolator.
- the optical mode whose profile has been altered, partially propagates within the optical isolator.
- the optical isolator's integrated optical structure may be inserted into a PIC photonic integrated circuit, for example to allow insulation between two optical devices.
- the invention may also be used to construct an optical insulator integrated optical structure using a magneto-optical layer made of a magnetic oxide, such as a magneto-optical garnet (YIG, BIG, Ce:YIG, etc . . . ), rather than ferromagnetic metals.
- a magneto-optical garnet YIG, BIG, Ce:YIG, etc . . .
- the garnet layer is deposited or affixed onto a lower insulating layer covering a base SOI.
- the method for manufacturing the integrated optical structure is schematically depicted in FIG. 3 . Regardless of the nature of the magneto-optical layer, the construction of the integrated optical structure proceeds in a like manner.
- the magneto-optical layer 32 is then deposited onto the lower insulating layer 31 , for example by a cathodic spraying method, during a second step of depositing 41 .
- the magneto-optical layer 32 is etched in order to give it a structure that makes it possible to increase the magneto-optical effect.
- An example of such a structure is a Bragg grating, in which the magneto-optical layer is periodically etched, which causes the magneto-optical effect to increase within a wavelength range.
- a third step of depositing 42 is used to deposit a second layer of an insulating material, for example silicon oxide SiO 2 atop the etched magneto-optical layer 32 in order to obtain the upper insulating layer 33 .
- the surface of the new assembly is itself made flat by a CMP method.
- a III-V semiconducting die 34 is affixed onto the upper insulating layer 33 deposited atop the magneto-optical layer 32 , for example, one made of ferromagnetic metal or garnet.
- the III-V semiconducting die 34 is treated in order to create the III-V active waveguide of the SOA optical amplifier, whose presence makes it possible to offset the optical power losses in this sort of optical isolator.
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Nonlinear Science (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Optical Integrated Circuits (AREA)
- Semiconductor Lasers (AREA)
- Light Guides In General And Applications Therefor (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
Abstract
Description
-
- at least one SOA optical amplifier comprising a waveguide comprising an n-doped semiconductor layer, a p-doped semiconductor layer, and an active zone disposed between the n-doped semiconductor layer and the p-doped semiconductor layer, associated with
- at least one optical isolator disposed between an SOI base and the SOA optical amplifier waveguide, comprising a magneto-optical layer disposed between a lower insulating layer and an upper insulating layer.
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- a first layer of an insulating material is deposited onto an SOI base,
- a magneto-optical layer is deposited onto the first layer of insulating material,
- a second layer of an insulating material is deposited onto the magneto-optical layer,
- a semiconducting die is affixed to the second layer of insulating material,
- the semiconducting die is treated in order to create an optical waveguide.
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- injecting an electrical current into the amplifying active area is now separated from the magneto-optical layer, which allows it to be optimized independent of the optimization of the magneto-optical layer;
- the technology for producing the optical device is based on III-V on SOI hybrid integration, so the manufacturing of the isolator is much easier than in the prior art, and the optical isolator may thereby be used on silicon PIC photonic integrated circuits.
Claims (12)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1159501 | 2011-10-20 | ||
| FR1159501A FR2981803B1 (en) | 2011-10-20 | 2011-10-20 | INTEGRATED OPTICAL STRUCTURE COMPRISING AN OPTICAL ISOLATOR |
| PCT/EP2012/070563 WO2013057138A1 (en) | 2011-10-20 | 2012-10-17 | Integrated optical structure comprising an optical isolator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| US20140247477A1 US20140247477A1 (en) | 2014-09-04 |
| US9106046B2 true US9106046B2 (en) | 2015-08-11 |
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ID=47040732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US14/349,394 Expired - Fee Related US9106046B2 (en) | 2011-10-20 | 2012-10-17 | Integrated optical structure comprising an optical isolator |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9106046B2 (en) |
| EP (1) | EP2769445B1 (en) |
| JP (1) | JP5873181B2 (en) |
| KR (1) | KR101604559B1 (en) |
| CN (1) | CN103891068B (en) |
| FR (1) | FR2981803B1 (en) |
| TW (1) | TWI491952B (en) |
| WO (1) | WO2013057138A1 (en) |
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| KR20220103537A (en) | 2021-01-15 | 2022-07-22 | 삼성전자주식회사 | Optical isolator and photonic integrated circuit including the same |
| CN114512893B (en) * | 2022-02-16 | 2024-06-25 | 中国电子科技集团公司第四十四研究所 | Heterogeneous single-chip unidirectional injection-locked semiconductor laser and preparation method thereof |
| EP4579314A1 (en) * | 2023-10-17 | 2025-07-02 | Kyocera Corporation | Optical integrated circuit |
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- 2012-10-17 EP EP12773324.4A patent/EP2769445B1/en active Active
- 2012-10-17 KR KR1020147010482A patent/KR101604559B1/en not_active Expired - Fee Related
- 2012-10-17 WO PCT/EP2012/070563 patent/WO2013057138A1/en not_active Ceased
- 2012-10-17 CN CN201280051661.6A patent/CN103891068B/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2769445A1 (en) | 2014-08-27 |
| TWI491952B (en) | 2015-07-11 |
| CN103891068A (en) | 2014-06-25 |
| CN103891068B (en) | 2016-06-29 |
| KR20140064988A (en) | 2014-05-28 |
| JP5873181B2 (en) | 2016-03-01 |
| EP2769445B1 (en) | 2016-04-13 |
| TW201333582A (en) | 2013-08-16 |
| KR101604559B1 (en) | 2016-03-17 |
| FR2981803B1 (en) | 2016-01-08 |
| FR2981803A1 (en) | 2013-04-26 |
| WO2013057138A1 (en) | 2013-04-25 |
| US20140247477A1 (en) | 2014-09-04 |
| JP2014532980A (en) | 2014-12-08 |
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