US8794232B2 - Disposable monodose inhaler for powdered medicaments - Google Patents
Disposable monodose inhaler for powdered medicaments Download PDFInfo
- Publication number
- US8794232B2 US8794232B2 US11/574,868 US57486807A US8794232B2 US 8794232 B2 US8794232 B2 US 8794232B2 US 57486807 A US57486807 A US 57486807A US 8794232 B2 US8794232 B2 US 8794232B2
- Authority
- US
- United States
- Prior art keywords
- inhaler according
- inhaler
- duct
- delivery duct
- drop region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
- 239000003814 drug Substances 0.000 title claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 23
- 239000002775 capsule Substances 0.000 claims abstract description 10
- 230000008021 deposition Effects 0.000 claims description 2
- 238000001746 injection moulding Methods 0.000 claims description 2
- 229940079593 drug Drugs 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 230000008093 supporting effect Effects 0.000 description 3
- 238000000151 deposition Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
Definitions
- the present invention relates to inhalers for powdered medicaments, and in particular to a disposable monodose inhaler.
- This type of inhaler has various drawbacks: a rather high cost; a significant complexity that makes its use rather difficult, in particular for elderly patients; a great difficulty in maintaining it in a satisfactory hygienic state over time; the risk that the powdered medicament is not properly delivered due to thickening or formation of a film caused by humidity or by other factors; the fact that usually most of the medicament does not reach the patient's lungs because it is deposited on the walls of mouth and throat.
- this type of inhaler essentially consists of a pipe-shaped body with a first portion, for housing a medicament-containing capsule, connected through a screen to a second portion, for delivering the powder, that the patient puts in his mouth.
- a button with a spike suitable to pierce the capsule placed in an adequate supporting member a button-supporting spring being arranged between the button and the capsule-supporting member to prevent a premature piercing of the capsule.
- the object of the present invention is to provide a disposable monodose inhaler which is free from said drawbacks. This object is achieved by means of a monolithic inhaler provided with a bottom duct in the delivering portion and suitable to house an autoperforating cartridge.
- the main advantage of the present inhaler is given by the presence of the secondary stream, delivered from the bottom duct, that supports and directs the primary stream, which carries the powdered medicament, so that the primary stream can climb over the patient's tongue. In this way there is prevented the excessive deposition of the medicament in the oropharingeal cavity and there is obtained a greater effectiveness of the treatment thanks to the larger amount of medicament that reaches the lungs.
- this inhaler is its low cost, thanks to the fact that notwithstanding the presence of the bottom duct it can still be manufactured in plastic by injection molding with a monolithic structure. Moreover, this inhaler is suitable to house an autoperforating cartridge, like the cartridge disclosed in WO 03/011708 in the name of one of the inventors, whereby the other members for capsule piercing described in the above-mentioned prior art inhaler can be dispensed with.
- FIG. 1 is a front perspective view of the inhaler
- FIG. 3 is a side view of the inhaler
- FIG. 5 is a rear perspective view of the inhaler.
- FIG. 6 is a sectional rear perspective view taken along the longitudinal midplane of the inhaler.
- an inhaler conventionally consists of a hollow substantially pipe-shaped body that has a first portion H, for housing the capsule or cartridge of the powdered medicament, and a second portion M, for delivering the medicament through a delivery duct D whose end is suitable to be placed in the patient's mouth.
- the wall W that defines the housing portion H there are formed one or more vertical slots S to provide air intakes to the inner region P where the powder drops.
- the illustrated embodiment there are provided three slots S, namely a central slot extending through the whole height of wall W at the midplane in distal position and other two shorter slots symmetrically arranged with respect to the central slot.
- the air entering through slots S forms a stream F that carries the powder from region P, through grid G, along the delivery duct D up to the patient's mouth.
- a second wall W′ that encloses wall W at least partially, for example along the rear half of the latter in the illustrated embodiment, and is spaced therefrom so as to obtain an interspace S′ between the two walls.
- the delivering portion M results therefore consisting of two ducts D, D′ one on top of the other separated by a horizontal baffle B.
- the secondary stream F′ supports the primary stream F and prevents the powder from depositing, also due to gravity, on the patient's tongue or on other walls of the oropharingeal cavity. This supporting and directing function is particularly important in case the patient holds the distal end of the inhaler too much inclined upwards.
- This supporting effect can be increased or decreased by changing the ratio between the cross-sections of ducts D, D′ and/or between the cross-sections of the air intakes S, S′ or other details.
- the two streams F, F′ can be adjusted through the design of the various parts of the inhaler in order to obtain several embodiments with different inhalation characteristics for different specific applications.
- the air intake S′ for the secondary stream F′ could be formed directly at the rear end of the secondary duct D′, in which case wall W′ would extend only below the powder drop region P.
- the dividing baffle B could be U-shaped rather than plane, so that the “air cushion” formed by the secondary stream F′ partially encloses the primary stream F also on the sides.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IT2004/000501 WO2006030459A1 (en) | 2004-09-16 | 2004-09-16 | Disposable monodose inhaler for powdered medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
US20070215151A1 US20070215151A1 (en) | 2007-09-20 |
US8794232B2 true US8794232B2 (en) | 2014-08-05 |
Family
ID=34959068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/574,868 Active 2029-04-30 US8794232B2 (en) | 2004-09-16 | 2004-09-16 | Disposable monodose inhaler for powdered medicaments |
Country Status (10)
Country | Link |
---|---|
US (1) | US8794232B2 (en) |
EP (1) | EP1799289B1 (en) |
CN (1) | CN100522274C (en) |
AT (1) | ATE555823T1 (en) |
DK (1) | DK1799289T3 (en) |
ES (1) | ES2382550T3 (en) |
MX (1) | MX2007003046A (en) |
PL (1) | PL1799289T3 (en) |
PT (1) | PT1799289E (en) |
WO (1) | WO2006030459A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0602897D0 (en) * | 2006-02-13 | 2006-03-22 | Jagotec Ag | Improvements In Or Relating To Dry Powder Inhaler Devices |
GB0611656D0 (en) | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
GB0611659D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
GB0919465D0 (en) * | 2009-11-06 | 2009-12-23 | Norton Healthcare Ltd | Airflow adaptor for a breath-actuated dry powder inhaler |
IT201600093878A1 (en) * | 2016-09-19 | 2018-03-19 | Hollycon Italy Pte Ltd S R L | SINGLE-DOSE INHALER TO LOSE FOR POWDER MEDICINES |
KR101992171B1 (en) * | 2017-06-27 | 2019-06-25 | 한국유나이티드제약 주식회사 | Inhaler for dry powder |
TWI673075B (en) * | 2018-11-01 | 2019-10-01 | 郭漢彬 | Guiding tube apparatus and drug delivery apparatus |
FR3104413B1 (en) * | 2019-12-11 | 2021-12-24 | Nemera La Verpilliere | Mouthpiece for product dispensing device |
IT202000005698A1 (en) | 2020-03-17 | 2021-09-17 | Everest Group Holding Sa | Device for inhalation of powdered acetylsalicylic acid and its relative use |
Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3994421A (en) * | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
US4648393A (en) * | 1984-11-02 | 1987-03-10 | Ackrad Laboratories, Inc. | Breath activated medication spray |
US4846168A (en) * | 1986-12-05 | 1989-07-11 | Mect Corporation | Inhaler |
US5002048A (en) * | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5224472A (en) * | 1990-02-09 | 1993-07-06 | Solange Quenderff | Inhalation device |
US5239993A (en) * | 1992-08-26 | 1993-08-31 | Glaxo Inc. | Dosage inhalator providing optimized compound inhalation trajectory |
US5301666A (en) | 1991-12-14 | 1994-04-12 | Asta Medica Aktiengesellschaft | Powder inhaler |
US5435297A (en) | 1991-08-29 | 1995-07-25 | Christoph Klein | Medical device for inhaling metered aerosols |
US5524613A (en) * | 1993-08-25 | 1996-06-11 | Habley Medical Technology Corporation | Controlled multi-pharmaceutical inhaler |
US5669378A (en) | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US6089227A (en) * | 1995-06-21 | 2000-07-18 | Microdrug Ag | Device for an inhaler |
US6116237A (en) * | 1996-04-29 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Methods of dry powder inhalation |
US6397840B1 (en) * | 1998-11-05 | 2002-06-04 | Delsys Pharmaceutical Corporation | Dry powder dispensing device |
US20030079743A1 (en) * | 2001-10-30 | 2003-05-01 | Genova Perry A. | Breath actuated dry powder inhaler |
US6615826B1 (en) * | 1999-02-26 | 2003-09-09 | 3M Innovative Properties Company | Slow spray metered dose inhaler |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITPG20010036A1 (en) | 2001-07-24 | 2003-01-24 | Marco Cecchini | SELF-PERFORATING CARTRIDGE FOR INHALATION DRIED DUST DISPENSERS |
-
2004
- 2004-09-16 US US11/574,868 patent/US8794232B2/en active Active
- 2004-09-16 WO PCT/IT2004/000501 patent/WO2006030459A1/en active Application Filing
- 2004-09-16 DK DK04787593.5T patent/DK1799289T3/en active
- 2004-09-16 PL PL04787593T patent/PL1799289T3/en unknown
- 2004-09-16 PT PT04787593T patent/PT1799289E/en unknown
- 2004-09-16 ES ES04787593T patent/ES2382550T3/en active Active
- 2004-09-16 MX MX2007003046A patent/MX2007003046A/en active IP Right Grant
- 2004-09-16 CN CNB2004800440148A patent/CN100522274C/en not_active Expired - Fee Related
- 2004-09-16 AT AT04787593T patent/ATE555823T1/en active
- 2004-09-16 EP EP04787593A patent/EP1799289B1/en active Active
Patent Citations (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3994421A (en) * | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
US4648393A (en) * | 1984-11-02 | 1987-03-10 | Ackrad Laboratories, Inc. | Breath activated medication spray |
US4846168A (en) * | 1986-12-05 | 1989-07-11 | Mect Corporation | Inhaler |
US5002048A (en) * | 1989-12-12 | 1991-03-26 | Makiej Jr Walter J | Inhalation device utilizing two or more aerosol containers |
US5224472A (en) * | 1990-02-09 | 1993-07-06 | Solange Quenderff | Inhalation device |
US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5435297A (en) | 1991-08-29 | 1995-07-25 | Christoph Klein | Medical device for inhaling metered aerosols |
US5301666A (en) | 1991-12-14 | 1994-04-12 | Asta Medica Aktiengesellschaft | Powder inhaler |
US5239993A (en) * | 1992-08-26 | 1993-08-31 | Glaxo Inc. | Dosage inhalator providing optimized compound inhalation trajectory |
US5524613A (en) * | 1993-08-25 | 1996-06-11 | Habley Medical Technology Corporation | Controlled multi-pharmaceutical inhaler |
US6089227A (en) * | 1995-06-21 | 2000-07-18 | Microdrug Ag | Device for an inhaler |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5669378A (en) | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US6116237A (en) * | 1996-04-29 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Methods of dry powder inhalation |
US6397840B1 (en) * | 1998-11-05 | 2002-06-04 | Delsys Pharmaceutical Corporation | Dry powder dispensing device |
US6615826B1 (en) * | 1999-02-26 | 2003-09-09 | 3M Innovative Properties Company | Slow spray metered dose inhaler |
US20030079743A1 (en) * | 2001-10-30 | 2003-05-01 | Genova Perry A. | Breath actuated dry powder inhaler |
Also Published As
Publication number | Publication date |
---|---|
EP1799289B1 (en) | 2012-05-02 |
MX2007003046A (en) | 2007-08-02 |
WO2006030459A1 (en) | 2006-03-23 |
DK1799289T3 (en) | 2012-05-29 |
CN101022846A (en) | 2007-08-22 |
CN100522274C (en) | 2009-08-05 |
ATE555823T1 (en) | 2012-05-15 |
EP1799289A1 (en) | 2007-06-27 |
ES2382550T3 (en) | 2012-06-11 |
PL1799289T3 (en) | 2012-10-31 |
PT1799289E (en) | 2012-06-01 |
US20070215151A1 (en) | 2007-09-20 |
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Legal Events
Date | Code | Title | Description |
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AS | Assignment |
Owner name: COSSI, GIAMPIERO, ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BARBERA, MARIO LA;CECCHINI, MARCO;REEL/FRAME:019070/0222 Effective date: 20070305 |
|
AS | Assignment |
Owner name: COSSI, GIAMPIERO, ITALY Free format text: CHANGE OF NAME;ASSIGNOR:COSSI, GIAMPIERO;REEL/FRAME:019228/0552 Effective date: 20070402 |
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STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
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CC | Certificate of correction | ||
AS | Assignment |
Owner name: HOLLYCON ITALY PTE. LTD.- S.R.L., ITALY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COSSI, GIAMPIERO;REEL/FRAME:036830/0144 Effective date: 20150716 |
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Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YR, SMALL ENTITY (ORIGINAL EVENT CODE: M2551) Year of fee payment: 4 |
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