US8299233B2 - Molecular in vitro diagnosis of breast cancer - Google Patents

Molecular in vitro diagnosis of breast cancer Download PDF

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US8299233B2
US8299233B2 US12/811,792 US81179209A US8299233B2 US 8299233 B2 US8299233 B2 US 8299233B2 US 81179209 A US81179209 A US 81179209A US 8299233 B2 US8299233 B2 US 8299233B2
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seq
nucleic acids
probe set
acids consisting
probe
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US20110009286A1 (en
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Fabrice Andre
Stefan Michiels
Suzette Delaloge
Marc Spielmann
Philippe Dessen
Philippe Vielh
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Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
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Centre National de la Recherche Scientifique CNRS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Definitions

  • the present invention describes a molecular in vitro diagnosis of breast cancers. More particularly, the invention relates to the use of molecular probes for the diagnosis evaluation of breast tumors.
  • CNB Core needle biopsy
  • FNA fine needle aspiration cytology
  • mammogram is currently considered as the gold standard for mass screening. Nevertheless, this approach is limited by a high rate of false negative results, especially in young women and in aggressive tumors. In addition, mammogram is limited by the fact that a significant proportion of women do not perform the test. These considerations point out the need for a screening test that would be better or complementary to mammogram and that would be based on an easier procedure.
  • WO 2007/048978 describes methods and compositions for the detection of molecular markers in order to diagnose cancer.
  • this document describes methods and compositions that can be used to detect the presence or evolution of a breast tumor in a patient.
  • micro-arrays for the evaluation of miss-regulated expressed genes, without interest for the expression of variants of genes.
  • WO 2004/065545 discloses a diagnostic and prognostic method of the breast cancer tumor status, wherein said method consists to compare the expression profile of at least 5 genes of a determined list of 70 genes to the expression profile of said at least 5 genes of a determined list of 70 genes of a control tumor.
  • the disclosed method can detect splicing variant of the mentioned at least 5 genes chosen among the list of 70 genes to determine the breast cancer status of a tumor.
  • One aim of the invention is to provide a molecular diagnosis to determine the status of a breast tumor.
  • Another aim of the invention provides micro-arrays to determine the benign or malignant status of a breast tumor.
  • Another aim of the invention provides a method using the micro-array to determine the benign or malignant status of a breast tumor.
  • the invention also provides a kit for the breast cancer diagnosis.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets, said multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, each nucleic acid sequence specifically hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
  • the invention discloses the use of a multiplicity of polynucleotide probe sets
  • KRT17 LOC440421, KRT6C and KRT6A genes, said genes being respectively represented by SEQ ID NO 5431; 5689; 5651 and 5682, the above mentioned definition of the nucleic acid sequence of each polynucleotide probe of a given pool of polynucleotide probe set applies with the exception that:
  • the invention is based on the unexpected observation made by the inventors that the variation of expression of some genes, and their variants when they exist, may characterize the evolution of a diagnosed breast tumor. More particularly, the variants of the invention are the products of a differential splicing, or alternative splicing.
  • the inventors have demonstrated that the variation of expression of at least 12 determined genes of a group of 275 determined genes, and of variants of said at least 12 determined genes when they exist, hallmarks the benign or malignant status of a breast tumor.
  • the invention describes the use of polynucleotide probes to characterize a benign versus malignant hallmark of a breast tumor, each polynucleotide probe hybridizing specifically with one gene, and at least one of its splicing variants when they exist, said gene splicing variant being able to be recognized by at least one polynucleotide probe.
  • splicing is a modification of genetic information after transcription, in which introns of precursor messenger RNA (pre-mRNA) are removed and exons of precursor messenger RNA are joined.
  • pre-mRNA precursor messenger RNA
  • the splicing prepares the pre-mRNA to produce the mature messenger RNA (mRNA), which then undergoes translation as part of the protein synthesis to produce proteins.
  • Alternative splicing in the sense of the invention, is the RNA splicing variation mechanism, in which the exons of the pre-mRNA are separated and reconnected so as to produce alternative ribonucleotide arrangements.
  • alternative splicing uses genetic expression to facilitate the synthesis of a greater variety of transcripts.
  • the pre-mRNA When the pre-mRNA has been transcribed from the DNA, it includes several introns and exons. The exons which are retained in the mRNA are determined during the splicing process.
  • the use of alternative splicing factors leads to a modification of the definition of a “gene” and imposes the variant notion.
  • a pre-mRNA containing 3 exons if it is considered that variants must contain at least one exon of the gene and at least one exon missing of said gene, can hypothetically produce 6 different variants, as the result of alternative splicing.
  • a gene is defined by the fact that it comprises the deoxyribonucleic acid sequence corresponding to the mRNA which results of the transcription of the DNA sequence, and after the splicing process. Then, the gene is characterized in that it comprises all the exons present in the genomic sequence of said gene.
  • All the 275 genes considered in the invention present a nucleic acid sequence chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
  • this gene can is characterized in the invention by the presence of a target region.
  • This target region corresponds to a nucleic acid sequence contained in the total nucleic acid sequence of the said gene.
  • this gene is defined by a target region, and its variant is defined by the same target region.
  • the difference between the gene and its variant is preferably determined by the fact that the nucleic acid sequence of said gene is longer than the nucleic acid sequence of its variant.
  • This recognizing by one target region allows a redundancy of the representativity of said gene. Indeed, the target region contained in a gene having one variant is thus recognized at least twice, i.e. when the gene is present and when the variant of this gene is present. This redundancy enhances the specificity of detection of the gene expression variation.
  • this gene is defined by at least two regions, these two regions characterizing the gene. These regions are therefore present in gene. These regions, also called target regions correspond to nucleic acid sequences contained in the total nucleic acid sequence of said gene. Moreover, these target regions of said gene are located at a different position in the sequence of said gene.
  • targets regions that are involved in the invention present a nucleic acid sequence chosen among the group consisting in SEQ ID NO 2939 to SEQ ID NO 4578.
  • a “variant” is defined as a polynucleotide molecule that differs from the reference polynucleotide molecule (the gene), but retains essential properties.
  • the gene and its variants share similar polynucleotide sequences with, for example, 70% of nucleic acids identity, preferably 80% of nucleic acids identity, preferably 90% of nucleic acids identity and more preferably 95% of nucleic acids identity.
  • the variants of the invention can be also considered as isoforms.
  • a polynucleotide sequence must contain at least one nucleotide sequence present in the said gene, this sequence corresponding to the target sequence defined above.
  • a variant is the unique variant of a gene
  • this variant has the same target region as its gene, preferably with a nucleic acid sequence with a size that is shorter than the size of the nucleic acid sequence of said gene. Since said variant corresponds to a splicing product of a gene, it generally has one or more exons lacking that are present in said gene. Nevertheless, it is possible, in some rare examples, that a variant of a gene has a nucleic acid sequence with a size which is higher than the size of the nucleic acid sequence of said gene.
  • a variant is a variant of a gene that has at least two variants, said variant has at least one difference in the presence of a nucleic acid sequence with respect to the given gene nucleic acid sequence.
  • the specific combination of the presence of at least one target sequence and the absence of at least one target sequence defines the specific characteristic of a given variant. Therefore, each variant is defined by a “bar code” corresponding to the diversity of the presence and absence of all the target sequences present in a gene.
  • FIG. 1A illustrates this example.
  • a variant of a gene is characterized in that it comprises at least on target region.
  • These target regions corresponds to polynucleotidic sequences chosen among the group consisting in SEQ ID NO 2939 to SEQ ID NO 4578.
  • a given variant of a gene can be characterized with respect to the target sequence by the fact it contains at least a target region, present in the gene corresponding to said variant, and must is devoid of at least one target region, present in the gene corresponding to said variant, only in the case of a gene that has at least two variants.
  • a variant of a gene having at least two variants is then characterized by a bar code which corresponds to a combination of the presence of at least one target region of the gene, corresponding to the variant, and the absence of at least one target region of the gene corresponding to the variant.
  • a variant can also be alternatively defined. This other definition is supported by the feature of the invention: the alternative splicing.
  • a gene constituted by at least 3 exons
  • some exons are fused to exons which are not naturally fused in the sequence of the gene.
  • E1, E2 and E3 one variant can be constituted by the fusion of E1 and E3.
  • the natural configuration corresponds to the sequence E1-E2-E3. Then the configuration observed in the variant, E1-E3, is considered as a non natural configuration.
  • variant presents a sequence that does not exist in the natural configuration of the gene. It generally corresponds to a junction of to distant exons, separated by at least one other exon. If the target region characterizing the variant corresponds to the junction between two exons, naturally distant in the normal configuration in the gene, said target region characterizes specifically said variant. This example is illustrated by FIG. 1B .
  • Example of genes having, or not, at least one variant are represented in FIG. 3 .
  • polynucleotide probes are used to detect the variation of expression of a gene, and/or its variants when they exist, to determine the status of a breast tumor.
  • polynucleotide probes are grouped to form a polynucleotide probe set.
  • the term “polynucleotide probe set” used in the invention defines a group of polynucleotide probes as described above.
  • a given set of polynucleotide probe contains from one polynucleotide probe to several polynucleotide probes.
  • the polynucleotide probe set of the invention contains one polynucleotide probe to three or four polynucleotide probes.
  • polynucleotide probes regrouped in a polynucleotide probe set of the invention are able to hybridize to the same target region.
  • the polynucleotides probes are also brought together to form a “pool of polynucleotide probe sets”.
  • the polynucleotides probes contained in the polynucleotide probe sets of a pool are able to specifically hybridize with nucleic acid sequences of a gene, and/or variants of said gene when they exist.
  • polynucleotide probes contained in the polynucleotide probe sets of a pool are able to specifically hybridize neither with nucleic acid sequences of a different gene, nor with nucleic acid sequences of variants of said different gene, when they exist.
  • genes KRT17 SEQ ID NO 5431
  • LOC440421 SEQ ID NO 5689
  • these genes are two different genes, but share a high similarity/identity in their nucleic acid sequence.
  • these two genes present some gene regions in their nucleic acid sequence which can be identical. If a target region is present in said gene region, therefore, the polynucleotide probe that recognize the target region contained in said gene region will be able to recognize the two genes.
  • polynucleotide probes of a pool of polynucleotide probe sets are able to characterize a gene and its variants. Moreover, a given gene, and its variants when they exist, can be detected only by the polynucleotide probes of the same pool of polynucleotide probe sets.
  • each gene, and its variants when present can be detected by all the polynucleotide probes of a probe set.
  • each gene can be recognized by all the polynucleotide probes of at least one polynucleotide probe set, i.e. each gene and its variants can be defined by at least one polynucleotide probe set.
  • a variant can be detected by two polynucleotide probes belonging to two different polynucleotide probe sets, provided that they belong to the same pool of polynucleotide probe set.
  • the multiplicity, pool, polynucleotide probe set, and polynucleotide probe interconnection are represented in FIG. 2 .
  • library comprising or consisting of at least one copy each of the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938
  • the library can contain one, or two, or three, or four, or five or six or seven or eight, or nine or ten copies of each polynucleotide probes represented by the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938.
  • the minimal library contains 2938 polynucleotides probes
  • the maximal library contains 29380 polynucleotides probes.
  • the preferred library of the invention contains 4582 polynucleotides probes.
  • a “benign breast tumor” is any non-cancerous breast abnormality. Some (not all) benign conditions can signal an increased risk for breast cancer. The most common benign breast conditions include fibrocystic breast condition, benign breast tumors, and breast inflammation. Depending on the type of benign breast condition and the patient's medical situation, treatment may or may not be necessary.
  • a “malignant breast tumor” refers” to a malignant tumor that has developed from cells in the breast. Malignant tumors penetrate and destroy healthy body tissues. A group of cells within a tumor may also break away and spread to other parts of the body. Cells that spread from one region of the body into another are called metastases.
  • base is used to define the components of the DNA or RNA, i.e. deoxyribonucleotides and ribonucleotides respectively.
  • nucleic acids “nucleic acid molecule”, “nucleic acid sequence”, “polynucleotidic sequence”, and “polynucleotide” are uniformly used to define a chain of bases that characterizing a DNA or an RNA molecule.
  • polynucleotide probe represent a fragment of nucleic acid molecule, corresponding to DNA or RNA, with a variable length.
  • the length of the polynucleotide probe is commonly comprised between 15 bases to 1000 bases, and preferably between 20 bases to 500 bases.
  • the polynucleotide probes defined in the invention comprise from 20 bases to 30 bases. These polynucleotide probes are defined by their nucleic acid sequence.
  • multiplicity and “combination” are used to define a group of polynucleotide probes sets and polynucleotide probes, respectively. Theses groups correspond to an ensemble of probes, or sets of probes, characterized in that they contains similar information.
  • each nucleic acid sequence corresponding to nucleic acid probe “specifically hybridizes with” a target region of the said gene.
  • each polynucleotide probe is able to hybridize with a gene, and/or its variants when they exist, defined above.
  • the polynucleotide probe thereby hybridizes to single-stranded nucleic acid molecule (gene and/or its variants, which are DNA or RNA) whose nucleic acid sequence allows base pairing due to complementarity between the nucleic acid sequence of the probe and the nucleic acid sequence of the gene and/or variants of said gene.
  • the base pairing (A-T;G-C) is a concept well known by the skilled man in the art.
  • Each polynucleotide probe is able to hybridize with one gene and/or at least one variant of said gene, in a specific region of said variant called target region.
  • Said target region is then defined as the region allowing the base pairing between polynucleotide probe and a gene and/or its variants, when they exist.
  • each polynucleotide probe is able to define a gene and/or at least one variant of said gene, when they exist.
  • each polynucleotide probe specifically hybridizes with a specific nucleic acid sequence contained in the target region. Moreover, each polynucleotide probes can recognizes a sequence overlapping partially with the sequence recognized by another probe of the same polynucleotide probe set.
  • each gene, or reference transcript can be expressed differentially in the form of variants.
  • These variants differ from each other by the presence or absence or the variation of a sequence of a specific region: the target region.
  • This region is liable to be recognized by one to three polynucleotide probes, said polynucleotide probes hybridizing with the same target region being brought together in a polynucleotide probe set.
  • the use of the multiplicity of polynucleotide probe sets of the invention allows to detect the variation of expression of at least 12 determined genes consisting in SEQ ID NO 5421, SEQ ID NO 5423, SEQ ID NO 5432, SEQ ID NO 5434, SEQ ID NO 5486, SEQ ID NO 5491, SEQ ID NO 5525, SEQ ID NO 5552, SEQ ID NO 5599, SEQ ID NO 5652, SEQ ID NO 5654 and SEQ ID NO 5683, and their variants when they exist, of the group of determined genes constituted by genes of the group constituted by SEQ ID NO 5419 to SEQ ID NO 5693, and a skill man in the art can determine if the breast tumor is malignant or benign.
  • the expression of a given gene and/or at least one of its variants belonging to the group of 12 determined genes corresponds to a “profile” similar to that of a benign tumor
  • the tumor of the patient will be considered as evolving to a benign status.
  • the expression of a gene and/or at least one of its variant belonging to the group of 12 genes corresponds to that of a “profile” similar to a malignant tumor, it will be considered that the tumor is a malignant tumor.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets chosen among 1640 probe sets of polynucleotides, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, each nucleic acid sequence hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
  • the invention discloses the use of a multiplicity of polynucleotide probe sets defined above, for determining the variation of the expression of at least 20 determined genes of a group of genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693,
  • the invention resides in the unexpected observation that the variation of expression of a group of at least 20 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets as above defined, for determining the variation of the expression of at least 35 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • the invention also resides in the unexpected observation that the variation of expression of a group of at least 35 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets previously defined, for determining the variation of the expression of at least 43 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693,
  • the invention also resides in the unexpected observation that the variation of expression of a group of at least 43 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets such as defined above, for determining the variation of the expression of at least 206 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • the invention also resides in the unexpected observation that the variation of expression of a group of at least 206 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor, and provide the best results.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets such as above defined, for determining the variation of the expression of 275 determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693.
  • the invention also resides in the unexpected observation that the variation of expression of 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
  • the invention describes the use of a multiplicity of polynucleotide probe sets that allow the detection of variation of expression 12 genes, and their variants when they exist, said variation defining the benign or malignant hallmark of the breast tumor.
  • the 12 genes, and their variants when they exist are represented by their nucleic acid sequences consisting in SEQ ID NO 5421, SEQ ID NO 5423, SEQ ID NO 5432, SEQ ID NO 5434, SEQ ID NO 5486, SEQ ID NO 5491, SEQ ID NO 5525, SEQ ID NO 5552, SEQ ID NO 5599, SEQ ID NO 5652, SEQ ID NO 5654 and SEQ ID NO 5683 and are specifically recognized by their target sequences.
  • the invention relates to the use of a multiplicity of polynucleotide probe sets for determining the variation the gene expression as defined above, and of at least one variant of said genes when present, said variant being represented by the nucleic acid sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694, the correspondence between each variant and its corresponding gene being represented in Table 1A-E and in Table 6.
  • the inventors have demonstrated that the determination of the variation of expression of at least 12 genes chosen among a group of 275 genes, and of at least one variant of each at least 12 genes give a good information about the benign or malignant status of a breast tumor, without important false positives.
  • the variation of expression of all the 275 determined genes and at least one of their variant allows the diagnostic.
  • the invention relates to the use as defined above, for the determination of the variation of expression of at least 12 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 12 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1A.
  • Table 1A represents the correspondences between the group of 12 determined genes and their corresponding variants.
  • SEQ ID Variants SEQ ID AK5 SEQ ID NO 5654 SEQ ID NO 4620 COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784; SEQ ID NO 5242; SEQ ID NO 5384 DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860; SEQ ID NO 5058; SEQ ID NO 5095; SEQ ID NO 5150; SEQ ID NO 5381; SEQ ID NO 5410; KIT SEQ ID NO 5423 SEQ ID NO 5107 KRT14 SEQ ID NO 5434 SEQ ID NO 4819; SEQ ID NO 4825; SEQ ID NO 4845; SEQ ID NO 4877; SEQ ID NO 4891; SEQ ID NO 4969 KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881 KRT5 SEQ ID NO 5432 SEQ ID NO 5279 MYH11 SEQ ID NO 5599 SEQ ID NO 4697; SEQ ID NO 4870; SEQ ID NO 5361; SEQ ID NO
  • the invention relates to the use as defined above, for the determination of the variation of expression of at least 20 determined genes of the group of 275 genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 20 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1B.
  • Table 1B represents the correspondences between the group of 20 determined genes and their corresponding variants.
  • SEQ ID Variants SEQ ID AK5 SEQ ID NO 5654 SEQ ID NO 5224 C2orf40 SEQ ID NO 5616 SEQ ID NO 4832 C9orf61 SEQ ID NO 5516 SEQ ID NO 4661 CNN1 SEQ ID NO 5457 SEQ ID NO 5181; SEQ ID NO 4666 COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784; SEQ ID NO 5242; SEQ ID NO 5384 DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860; SEQ ID NO 4908; SEQ ID NO 5058; SEQ ID NO 5095; SEQ ID NO 5150; SEQ ID NO 5381; SEQ ID NO 5410; SEQ ID NO 5107 DMN SEQ ID NO 5643 SEQ ID NO 4610; SEQ ID NO 5120 EDN3 SEQ ID NO 5673 SEQ ID NO 5405 IL33 SEQ ID NO 5624 SEQ ID NO 4927 KIT SEQ ID NO 5423 SEQ ID NO 5177
  • the invention relates to the use as defined above, for the determination of the variation of expression of at least 35 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 35 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1C.
  • Table 1C represents the correspondences between the group of 35 determined genes and their corresponding variants.
  • SEQ ID Variants SEQ ID ACTA2 SEQ ID NO 5462 — AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620; SEQ ID NO 4658; SEQ ID NO 4694; SEQ ID NO 4786; SEQ ID NO 4794; SEQ ID NO 4856; SEQ ID NO 5078; SEQ ID NO 5224; SEQ ID NO 5391 C2orf40 SEQ ID NO 5616 SEQ ID NO 4832 C9orf61 SEQ ID NO 5516 SEQ ID NO 4661 CNN1 SEQ ID NO 5457 SEQ ID NO 5181 CNTNAP3 SEQ ID NO 5627 SEQ ID NO 4675 COL14A1 SEQ ID NO 5594 SEQ ID NO 5102 COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784; SEQ ID NO 5242; SEQ ID NO 5384 CRYAB SEQ ID NO 5470 SEQ ID NO 4858 DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4586
  • the invention relates to the use as defined above, for the determination of the variation of expression of at least 43 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 43 determined genes, wherein the correspondence between genes and their variant s is indicated in the following table 1D.
  • Table 1D represents the correspondences between the group of 43 determined genes and their corresponding variants.
  • SEQ ID Variants SEQ ID ACTA2 SEQ ID NO 5462 SEQ ID NO 4633; SEQ ID NO 4795; SEQ ID NO 4956; SEQ ID NO 5052; SEQ ID NO 5093; SEQ ID NO AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620; SEQ ID NO 4658; SEQ ID NO 4694; SEQ ID NO 4786; SEQ ID NO 4794; SEQ ID NO 4856; SEQ ID NO 5078; SEQ ID NO 5224; SEQ ID NO 5391 C2orf40 SEQ ID NO 5616 SEQ ID NO 4832; SEQ ID NO 4862 C9orf61 SEQ ID NO 5516 SEQ ID NO 4661 CNN1 SEQ ID NO 5457 SEQ ID NO 5181; SEQ ID NO 5185 CNTNAP3 SEQ ID NO 5627 SEQ ID NO 4597; SEQ ID NO 4675 COL14A1 SEQ ID NO 5594 SEQ ID NO 5102 COL17A1 SEQ ID NO 5683 SEQ ID NO
  • the invention relates to the use as defined above, for the determination of the variation of expression of at least 206 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 206 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1E.
  • Table 1E represents the correspondences between the group of 206 determined genes and their corresponding variants.
  • SEQ ID Variants SEQ ID A2M SEQ ID NO 5420 SEQ ID NO 4855; SEQ ID NO 4945; SEQ ID NO 5092; SEQ ID NO 5248; SEQ ID NO 5328; SEQ ID NO 5363; SEQ ID NO 5364 ACTA2 SEQ ID NO 5462 SEQ ID NO 4632; SEQ ID NO 4633; SEQ ID NO 4795; SEQ ID NO 4956; SEQ ID NO 4959; SEQ ID NO 4981; SEQ ID NO 5052; SEQ ID NO 5057; SEQ ID NO 5093; SEQ ID NO 5316; SEQ ID NO 5350; SEQ ID NO 5369 ACTG2 SEQ ID NO 5463 SEQ ID NO 4774; SEQ ID NO 4777; SEQ ID NO 4940 ADD3 SEQ ID NO 5588 SEQ ID NO 4629 AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620; SEQ ID NO 4658; SEQ ID NO 4694; SEQ ID NO 4786; SEQ ID NO 47
  • the invention relates to the use as defined above, for the determination of the variation of expression of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of their variants when they exist, wherein the correspondence between genes and their variants is indicated in the following table 6.
  • the invention relates to the use of a multiplicity of polynucleotide probe sets for determining the variation of the gene expression as defined above, and of its variants when present, wherein target regions are characterized by the polynucleotide sequences SEQ ID NO 2939 to 4578, each target region of each gene, and of each variant when they exist, being represented in Table 6.
  • each of the 12 genes has the following target region:
  • the invention discloses the use of a multiplicity of polynucleotide probe sets for determining the variation of the gene expression as defined above, and/or of their variants when present, wherein each polynucleotide probe contained in a polynucleotide probe set is represented by the nucleic acid sequence of the library consisting in SEQ ID NO 1 to SEQ ID NO 2938, the correspondence between each polynucleotide probe and its corresponding target region, said target region corresponding to a gene and its variants when present, being represented in Table 6.
  • each of the 12 genes is recognized by the following polynucleotide probes:
  • the invention also relates to the use of a multiplicity of at least 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets, the nucleic acid sequences of the polynucleotide probes contained in said 50 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 136; 137; 138; 157; 158; 159; 167; 168; 169; 171; 172; 173; 177; 312; 313; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374; 375; 790; 791; 792; 793; 794; 7
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 50 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
  • 143 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
  • the above mentioned polynucleotide probes contained in the 50 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
  • the invention relates to the use of a multiplicity of at least 100 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotides probes contained in said 100 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NO 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 312; 313; 314; 315; 316; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 363;
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 100 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
  • 282 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
  • the above mentioned polynucleotide probes contained in the 100 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
  • the invention relates to the use of a multiplicity of at least 150 polynucleotide probe sets as previously defined, the nucleic acid sequence of the polynucleotides probes contained in said 150 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 197; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 3
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 150 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three
  • the above mentioned polynucleotide probes contained in the 150 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
  • a preferred embodiment of the invention relates to the use of a multiplicity of at least 200 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotide probes contained in said 200 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 121; 122; 123; 130; 131; 132; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 195; 196; 197; 198; 199; 200; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337
  • the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 200 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954
  • 565 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952;
  • the above mentioned polynucleotide probes contained in the 200 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
  • the invention relates to the use of a multiplicity of at least 1228 polynucleotide probe sets as defined above, containing 3985 polynucleotide probes, the nucleic acid sequence of the polynucleotide probes contained in said 1228 polynucleotide probe sets being represented in the first 1228 lines of the Table 7,
  • a preferred embodiment of the invention discloses the use of a multiplicity of 1640 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotide probes contained in said 1640 polynucleotide probe sets being represented in Table 7,
  • the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the sub-group of genes is constituted by 12 to 259 genes chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
  • the sub-groups of genes contain at least 12 genes, as described above.
  • the sub-group of genes can also contain advantageously 19 genes, or advantageously 32 genes, or advantageously 40 genes, or advantageously 214 genes or more advantageously 259 genes.
  • each gene of the sub-groups of genes, and/or its variants when they exist are specifically recognized by at least one polynucleotide probe belonging to a polynucleotide probe set of a pool of polynucleotide probe sets.
  • the invention relates to the use of a multiplicity of polynucleotide probe sets, wherein the sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
  • the inventors have unexpectedly demonstrated that a group of 259 genes, and/or their variants when they exist, give some powerful information to precisely determine the benign or malignant status of a breast tumor.
  • each gene, and its variants when they exist is specifically recognized by at least one polynucleotide probe belonging to a polynucleotide probe set of a pool of polynucleotide probe sets.
  • the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the polynucleotide probe sets are chosen among at least 50 polynucleotide probe sets, particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
  • the multiplicity of polynucleotide probe sets is of at least 50 polynucleotide probe sets, and particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, and more advantageously at least 200 polynucleotide probe sets.
  • the Top 50 polynucleotide probe sets contains a combination of polynucleotide probes characterized by SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 3
  • the Top 100 polynucleotide probe set contains a combination of polynucleotide probes characterized by SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 332, SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO
  • the Top 150 polynucleotide probe set contains a combination of polynucleotide probes characterized by polynucleotide probes chosen among SEQ ID NO 1 to SEQ ID NO 2938.
  • the Top 200 polynucleotide probe set contains a combination of polynucleotide probes characterized by polynucleotide probes chosen among SEQ ID NO 1 to SEQ ID NO 2938.
  • the multiplicities used can also be represented by a number of at least 300 polynucleotide probe sets, more particularly at least 400 polynucleotide probe sets, more particularly at least 500 polynucleotide probe sets, more particularly at least 600 polynucleotide probe sets, more particularly at least 700 polynucleotide probe sets, more particularly at least 800 polynucleotide probe sets, more particularly at least 900 polynucleotide probe sets, more particularly at least 1000 polynucleotide probe sets, more particularly at least 1100 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, more particularly at least 1400 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets.
  • the 1228 polynucleotide probe sets are an advantageous multiplicity of probe sets defined to diagnose the benign versus malignant status of a breast tumor.
  • the invention also relates to the use of a multiplicity of polynucleotide probe sets, wherein polynucleotide probe sets are chosen among at least 50 polynucleotide probe sets, particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938,
  • sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
  • the benign versus malignant status of a breast tumor can be determined by the use of 2938 polynucleotide probes.
  • the invention describes the use of a multiplicity of polynucleotide probe sets, wherein a variant of a given gene is chosen among the group of variants consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
  • each gene can have:
  • the invention discloses the use of a multiplicity of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe, each probe being able to specifically hybridize with at least one gene, and/or its variants when they exist, to determine the benign or malignant status of a breast tumor.
  • the invention discloses the use of 2938 polynucleotides probes, assembled in polynucleotide probe sets, said polynucleotides probes being able to detect the variation of expression of at least one gene chosen among 259 genes, and/or its variants when present.
  • the variation of expression of at least 839 variants and the variation of expression 259 genes can be detected by the use of the multiplicities of polynucleotide probe sets described above.
  • the invention also discloses a library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
  • This library consists in all the polynucleotide probes that can be regrouped in 1640 representative probe sets of the invention. Then, the library consists in a group that contains 2938 polynucleotide probes.
  • the invention advantageously discloses a multiplicity of polynucleotide probes sets chosen among the nucleic acid sequences of the library described above, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 214 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
  • the group of polynucleotide probes represents a combination of 1228 polynucleotide probe sets.
  • the group allows to detect the variation of expression of 214 genes and/or their variants when they exist.
  • the invention advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8 , wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 40 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
  • the group of polynucleotide probes represents a combination of 200 polynucleotide probe sets.
  • the group allows to detect the variation of expression of 40 genes and/or their variants when they exist.
  • the invention more advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8 , wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 32 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
  • the group of polynucleotide probes represents a combination of 150 polynucleotide probe sets.
  • the group allows to detect the variation of expression of 32 genes and/or their variants when they exist.
  • the invention more advantageously discloses multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8 , wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 19 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
  • the set of polynucleotide probe being able to specifically hybridize with 19 genes, and/or their variants when they exist, comprises the polynucleotide probes consisting in SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 331, S
  • the group of polynucleotide probes represents a combination of 100 polynucleotide probe sets.
  • the group allows to detect the variation of expression of 19 genes and/or their variants when they exist.
  • the invention advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8 , wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 12 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
  • the set of polynucleotide probe being able to specifically hybridize with 12 genes, and/or their variants when they exist, comprises the polynucleotide probes consisting in SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO
  • the group of polynucleotide probes represents a combination of 50 polynucleotide probe sets.
  • the group allows to detect the variation of expression of 12 genes and/or their variants when they exist.
  • the invention also discloses a multiplicity of 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
  • the invention relates to a multiplicity of at least 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets, the nucleic acid sequences of the polynucleotide probes contained in said 50 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 136; 137; 138; 157; 158; 159; 167; 168; 169; 171; 172; 173; 177; 312; 313; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374; 375; 790; 791; 792; 793; 794; 795; 9
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
  • the invention also discloses a multiplicity of 100 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
  • the invention relates to a multiplicity of at least 100 polynucleotide probe sets as above defined, the nucleic acid sequences of the polynucleotides probes contained in said 100 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NO 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 312; 313; 314; 315; 316; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 363; 364; 365
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
  • the invention also discloses a multiplicity of 150 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
  • the invention relates to a multiplicity of at least 150 polynucleotide probe sets previously defined, the nucleic acid sequences of the polynucleotides probes contained in said 150 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 197; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies.
  • Another preferred embodiment of the invention relates to a multiplicity of 200 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
  • a preferred embodiment of the invention discloses a multiplicity of at least 200 polynucleotide probe sets defined above, the nucleic acid sequences of the polynucleotide probes contained in said 200 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 121; 122; 123; 130; 131; 132; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 195; 196; 197; 198; 199; 200; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 3
  • each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes
  • SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284;
  • Another particular embodiment of the invention relates to a multiplicity of 1228 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
  • the invention in a particular embodiment, relates to a multiplicity of at least 1228 polynucleotide probe sets as defined above, containing 3985 polynucleotide probes, the nucleic acid sequences of the polynucleotide probes contained in said 1228 polynucleotide probe sets being represented in the first 1228 lines of the Table 7.
  • the invention discloses, in another preferred embodiment, a multiplicity 1640 polynucleotide probe sets as defined above.
  • the invention related to a multiplicity of 1640 polynucleotide probe sets as previously defined, the nucleic acid sequences of the polynucleotide probes contained in said 1640 polynucleotide probe sets being represented in Table 7.
  • the invention also discloses a micro-array comprising or consisting in a multiplicity of polynucleotide probe sets as defined above.
  • the invention discloses a micro-array comprising the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or a multiplicity of polynucleotide probe sets:
  • the microarray refers to nucleic acid molecule covalently attached to an inert chemical surface, such as coated glass slides or gene chips, and to which a mobile DNA target is hybridized. All the commonly used surfaces can also serve as a support.
  • the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, by determining the variation of the expression of a gene, and/or at least one of its variants when present, of a sub-group comprising at least 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677, comprising:
  • the invention relates to a method for the determination, preferably in vitro and/or ex vivo, of the benign or malignant state of a breast tumor in a biological sample from a subject, by determining the variation of the expression of
  • the invention also describes a method that allows the determination of the status, benign or malignant, of a breast tumor.
  • a biological sample corresponding to a breast tumor is used as a source of nucleic acid molecule.
  • Said biological sample refers to a sample obtained from an organism or from components (e.g., cells) of an organism.
  • the sample may be one of any biological tissue. Frequently the sample could be a “clinical sample” which is a sample derived from a patient.
  • Such samples include, but are not limited to, FNA sample, CNB sample, ductal lavage and blood sample.
  • Biological samples may also include sections of tissues such as frozen sections taken for histological purposes.
  • the subject from which biological sample is provided is commonly a woman, afflicted, or suspected to be afflicted by a breast tumor.
  • the subject can also be a man, with, or suspected to have, a breast cancer.
  • all the mammals can be diagnosed by the method provides by the invention, with the proviso that they could develop a breast tumor.
  • nucleic acid molecules extracted from the biological sample are RNA.
  • the method of the invention consists in contacting nucleic acid molecules extracted from the biological sample of a subject, with a multiplicity of polynucleotide probe sets.
  • Each polynucleotide probe set contains at least one polynucleotide probe.
  • the contact between the polynucleotide probe set, and more particularly the polynucleotide probes contained in each polynucleotide probe set, allows to form a nucleic acid complex between the nucleic acid molecule corresponding to a gene, and/or its variants when they exist, and a polynucleotide probe.
  • nucleic acid molecules are labeled with any know labeling agents (radioisotopes, enzymes, fluorescent molecule . . . ).
  • labeling agents radioisotopes, enzymes, fluorescent molecule . . . .
  • the hybridization is made according a standard procedure, by modulating if necessary saline concentration and temperature.
  • the protocol used for hybridization is well known by the skilled man in the art.
  • the presence and amount of the formed nucleic acid complex is detected, by the detection of hybridized nucleic acid molecules which have been labeled with labeling agent, with a specific detection method fitting to the used labeled agent.
  • each probe set that have hybridized with labeled nucleic acid molecules allows to attribute a value of hybridization.
  • the given value is dependant of the labeling agent.
  • the tumor profile is compared to a reference profile, in particular profile of tumors deriving from biological sample of non afflicted by breast cancer subjects, or derived from biological sample of a subject afflicted by a benign or a malignant breast tumor.
  • the tumor profile assayed can be compared with tumor profile of patients afflicted by benign breast tumor or malignant breast tumor.
  • the comparison is made by using software commonly used in this type of comparison, and well known and described in the art.
  • the breast tumor derived from the biological sample of a patient is a benign tumor or a malignant tumor.
  • the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein the determination of the variation of the expression of a gene, and/or at least one of its variants when present, of a sub-group comprising at least 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677, comprises:
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, by determining the variation of the expression of at least 20 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • said 20 determined genes being represented by the following nucleotidic sequences: SEQ ID Nos 5421; 5423; 5432; 5434; 5457; 5486; 5491; 5513; 5516; 5525; 5532; 5552; 5599; 5616; 5624; 5643; 5652; 5654; 5673 and 5683.
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, by 35 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • Another preferred embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as previously defined, by determining the variation of the expression of at least 43 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • Another particular embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, by determining the variation of the expression of at least 206 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
  • the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, by determining the variation of the expression of 275 determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693.
  • Another particular embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, wherein said variant being represented by the nucleic acid sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694, the correspondence between each variant and its corresponding gene being represented in Table 1A-E and Table 6.
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, wherein target regions are characterized by the polynucleotide sequences SEQ ID NO 2939 to 4578, the each target region of each gene, and of each variant when they exist, being represented in Table 6.
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as previously defined, wherein each polynucleotide probe contained in a polynucleotide probe set is represented by the nucleic acid sequence of the library consisting in SEQ ID NO 1 to SEQ ID NO 2938,
  • each polynucleotide probe and its corresponding target region said target region corresponding to a gene and its variants when present, being represented in Table 6.
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein the sub-group of genes is constituted by 12 to 259 genes chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
  • the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor described above, wherein the sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
  • the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein said set of polynucleotide probes are chosen among the group consisting in:
  • polynucleotide probe sets particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probes sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
  • the sub-groups of 50, 100, 150, 200 polynucleotide probe sets are defined as the Top sub-groups allowing to determine the benign or malignant status of the tumor.
  • the multiplicity of probe sets can be constituted by at least 300 polynucleotide probe sets, more particularly at least 400 polynucleotide probe sets, more particularly at least 500 polynucleotide probe sets, more particularly at least 600 polynucleotide probe sets, more particularly at least 700 polynucleotide probe sets, more particularly at least 800 polynucleotide probe sets, more particularly at least 900 polynucleotide probe sets, more particularly at least 1000 polynucleotide probe sets, more particularly at least 1100 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, more particularly at least 1400 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets.
  • polynucleotide probes contained in the polynucleotide probe sets used in the method of the invention are chosen among a library of nucleic acid sequences consisting SEQ ID NO 1 to SEQ ID NO 2938.
  • the invention discloses a method described above, wherein a variant of a given gene is chosen among the group of variants consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
  • the method of the invention allows to detect the variation of expression genes, and their variants when they exist, said genes being characterized in that they consist in the nucleic acid sequences chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677 and said variants being characterized in that they consist in the nucleic acid sequence chosen among the group consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
  • a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor wherein the variation of expression of a gene, and/or at least one of its variants when present, said gene being chosen in the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693, is
  • Each gene expression, and expression of its variants if they exist, revealed by the method of the invention corresponds to an expression product of a gene of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
  • variants are normally expressed in a subject non afflicted by breast cancer. These variants are also expressed in the biological of subject afflicted by benign breast cancer or malignant breast cancer. Each variant have a specific expression level corresponding to the state of the breast cancer. Each variant can then be overexpressed compare to the same variant expressed in a normal subject, or under expressed comparing to the same variant expressed in a normal subject.
  • the genes, and/or their variants are up-regulated, preferably when their expression levels are more than 1.7 fold higher than the expression levels of said genes in a patient non afflicted by a breast tumor, and significantly different (preferably with a significant coefficient value of less than 0.05).
  • the genes, and/or their variants are down-regulated, preferably when their expression levels are less than 1.7 fold lower than the expression levels of said genes in a patient non afflicted by a breast tumor, and significantly different (preferably with a significant coefficient value of less than 0.05).
  • the invention discloses a method described above, wherein the nucleic acid molecules from the biological sample of the subject are mRNA/or cDNA, said mRNA resulting from the expression of the genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693, and/or at least one of their variants when present, represented by the nucleotidic sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694.
  • nucleic acid molecules are extracted from the biological sample of the subject, prior to be contacted with the set of polynucleotide probes, immobilized in a support.
  • RNA are extracted from the biological sample, eventually, mRNA are isolated from the total RNA.
  • mRNA are reverse-transcripted with a standard procedure.
  • the invention relates to a kit for the in vitro and/or ex vivo determination of benign or malignant status of a breast tumor, comprising:
  • the invention relates to a kit for the in vitro and/or ex vivo determination of benign or malignant status of a breast tumor, comprising the following group of polynucleotide probes:
  • SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies, or
  • SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies, or
  • SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies, or
  • SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284;
  • the invention also relates to
  • the micro-array comprises 1228 polynucleotide probe sets that represent the best multiplicity of polynucleotide probe sets to characterize efficiently the benign or malignant status of the breast tumor of a subject.
  • the kit of the invention may contain protocol and molecules to label nucleic acid molecules used to be contacted with the micro-array. Also, the kit of the invention may contain protocol and material for the extraction and purification of the nucleic acid molecules from the biological sample of a subject.
  • the contain of the kit is not limited to the described materials and protocols described above, and may contain any other material or procedures that can help a skilled man in the art to use the kit of the invention.
  • FIGS. 1 TO 6 ILLUSTRATE THE INVENTION
  • FIG. 1A represents a gene containing 3 exons, and its variants that lack at least one exon.
  • T represents a Target region.
  • FIG. 1B represents a gene containing 3 exons, and its variant that lacks one exon.
  • T represents a Target region.
  • FIG. 2 represents the notions of multiplicity, pool, probe set and probes of the invention.
  • FIG. 3A to 3G represent the gene and its variant when they exist and the corresponding target region.
  • FIG. 3A represents a gene having no variant and having one target region.
  • FIG. 3B represents a gene having no variant and having two target regions.
  • FIG. 3C represents a gene having one variant and having one target region.
  • FIG. 3D represents a gene having one variant and having two target regions.
  • FIG. 3E represents a gene having two variants and having two target regions.
  • FIG. 3F represents a gene having two variants and having three target regions.
  • FIG. 3G represents a gene having two variants and having three target regions, one of its target regions being in a configuration different in variant and gene.
  • FIG. 4 represents Heatmap of the 1656 exon-probes that present a more than two fold higher intensity in malignant condition.
  • the FIG. 4 reports the intensities of exon-probes that present more than a two-fold higher intensity in malignant tumors.
  • Each column represents a sample, and each raw represent an exon-probe.
  • FIG. 5 represents the correlation of each specimen with the average benign and malignant profiles.
  • Each tumor is classified according to its correlation with the average expressions of the probes in the benign and malignant group respectively during one leave-one-out-step.
  • the bisecting line defines a region of benign prediction (bottom right triangle) and malignant prediction (upper left triangle). Tumors from the benign group are depicted in black, and those from the malignant group, in grey. Any misclassifications correspond to benign samples located in the malignant prediction area and vice versa.
  • FIG. 6 represents the correlation of each specimen in the validation set with the average benign and malignant profiles of the preferred 1,228 signature polynucleotide probe sets obtained on the patients in the training set.
  • the bisecting line defines a region of benign prediction (bottom right triangle) and malignant prediction (upper left triangle). Tumors from the benign group are depicted in black, and those from the malignant group, in grey. Any misclassifications correspond to benign samples located in the malignant prediction area and vice versa.
  • 56652 probes (8%) presented a different intensity between malignant and benign conditions (adjusted p value ⁇ 0.05).
  • 37858 were exon-probes (B, T, and F) and 18794 were junction-probes (C, D, E).
  • 17441 were higher in malignant as opposed to benign diseases.
  • the 17441 exon-probes (B, T, F) that were found higher in malignant condition referred to 12091 exons and 3391 genes.
  • 1656 presented more than a two fold increased intensity in malignant conditions as compared to benign tumors. Heatmap of intensities for these 1656 probes is reported in FIG. 4 .
  • These 1656 probe sets referred to 1178 exons and 363 genes.
  • the level of gene expression was then determined as reported in patients and methods section.
  • 3733 were differentially expressed between cancer and benign conditions (adjusted p value ⁇ 0.05). This accounts for 7% of the overall genes included in the array and 31% of the filtered genes. Of these, 1984 were overexpressed in malignant condition.
  • Several of these genes are currently being targeted in therapeutics including TOP2A, VEGFA, AURKA, PARP1, RAS. Seventy-two genes presented more than a two fold increase of the mean value in breast cancer.
  • FIG. 3 reports the dot-plots for gene expression of the top 10 overexpressed genes. Two (PTTG1, NET1) of the 10 most overexpressed genes were considered as potential new therapeutic targets given their oncogenic properties.
  • 2675 exons (adjusted p value ⁇ 0.05) overexpressed in malignant condition who were not located within the 1984 filtered genes whose geometric mean values differ between cancer and benign lesions. These 2675 exon-probes were located in 1559 genes. The splice index for the 2675 exon is reported in supplementary table 4. Numbers of these over-expressed exons located within unchanged genes have potential oncogenic properties.
  • the inventors developed a molecular classifier for breast cancer diagnosis on FNA samples.
  • Sample amplification and labeling was performed using the WT-Ovation Pico RNA Amplification System and the FL-Ovation cDNA Biotin Module v2 (NuGen, Inc., part #'s 3300-60 and 4200-60) according to manufacturer's instructions.
  • a pan-genomic array has been designed to detect 138,636 splicing events. 20,649 genes are analyzed using this array. The overall number of probes included in this array was 6,079,562. The present study was focused on 703,680 Evidenced probes.
  • the arrays were washed and stained using the FS450-0001 Fluidics protocol prior to scanning using the Affymetrix GeneChip® Scanner 3000 7G. .DAT and .CEL images were visually inspected for anomalies and accurate grid placement.
  • the .CEL files were imported into Partek® Genomics Suite and the data were processed using the Robust Multichip Average (RMA) background correction method followed by GC content background correction. Quantile normalization was performed across all arrays, and then data was Log2 transformed and mean probe summarization was performed.
  • RMA Robust Multichip Average
  • the inventors filtered out probes whose expression varied little across the 94 patient training set as follows: first the inventors floored the expression values at 10 (i.e. all expression values lower than 10 were replaced by 10), and secondly they deleted a probe from the data set if the ratio of the maximum by minimum intensity across the 94-patient set was higher or equal to 5 and if the difference between the maximum and minimum intensity was higher or equal to 100. In total 176,832 probes were retained for analysis after the pre-filtering step.
  • the point biserial correlation coefficient was calculated for each probe between probe expression and a binary indicator which value was defined by the status of the patient (the indicator took the value 0 in patients who had benign tissue and the value 1 in tissues from patients with tumors) (Kraemer H C: Biserial correlation, in Encyclopedia of Statistical Science, Vol 1. Edited by Kotz S, Read C B. New York, Wiley, 1982, pp 276-280).
  • the probes with the highest absolute correlation are those which are the most likely correlated with the occurrence of a tumor.
  • the inventors used the t-test to test whether the point biserial correlation values were significantly different from 0 (Kraemer HC: Biserial correlation, in Encyclopedia of Statistical Science, Vol 1. Edited by Kotz S, Read C B. New York, Wiley, 1982, pp 276-280). In order to take the multiple testing issues into account they used a very stringent cut-off for statistical significance: 10e-8 (1 out of 100 million).
  • Leave-one-out cross-validation was used to estimate the prediction accuracy of the prediction rule.
  • One sample is left out, and the remaining samples are used to build the prediction rule, which is then used to classify the left-out sample.
  • the entire model-building process was repeated for each leave-one-out training set to provide unbiased estimates of the prediction accuracy (Ntzani E E, Vietnamesenidis J P. Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment. Lancet 2003; 362: 1439-44; Simon R, Radmacher M D, Dobbin K, McShane L M. Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification.
  • the inventors repeated the above performance evaluation procedure based on leave-one-out cross-validation for different p-value thresholds for signature genes in order to find an optimal prediction rule yielding the lowest number of misclassified patients. They tried the following four p-values thresholds to define the signature genes: 10e-11, 10e-10, 10e-09 and 10e-8.
  • the inventors also provide subsets of 50, 100, 150 and 200 polynucleotide probe sets whose expression can be used to classify the benign and malignant status of tissues of new patients.
  • the polynucleotide probe sets with positive correlation are those which have increased expression in malignant tissues, those with negative correlation have increased expression in the benign tissues.
  • the inventors developed an optimal prediction rule based on the methodology explained above.
  • the preferred p-value threshold for defining signature genes was p ⁇ 10e-9. This p-value threshold corresponds to the first 1228 polynucleotide probe sets in Table 3 (with identifier no 1 to no 1228).
  • leave-one-out cross-validation to estimated the prediction accuracy of the prediction rule with this particular threshold, they obtained 0 out of 24 patients (0%) with benign status that were misclassified and 0 out of 70 patients with malignant status that were misclassified (0%). This corresponds to a sensitivity of 100% and a specificity of 100%.
  • NM_000109.2 BI551231.1 EST 1 3 1756.026.1-C_at ⁇ 0.89221 0.8922081 18.94884 ⁇ 1e ⁇ 16 1756.026.
  • NM_000109.2 M63075.1 mRNA 1 4 1756.022.4-T_at ⁇ 0.87666 0.87666398 17.47788 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 5 1756.011.1-B_at ⁇ 0.87581 0.87581182 17.40484 ⁇ 1e ⁇ 16 1756.011.
  • NM_000109.2 AX114289.1 GENBANK_PATENT 1 6 1308.008.1-C_at ⁇ 0.86492 0.86492412 16.52922 ⁇ 1e ⁇ 16 1308.008. NM_130778.1 BE148646.1 EST 1 7 1756.022.3-F_at ⁇ 0.84937 0.84936983 15.43558 ⁇ 1e ⁇ 16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1 8 3861.020.1-D_at ⁇ 0.84359 0.84358795 15.06806 ⁇ 1e ⁇ 16 3861.020.
  • NM_022844.1 AY520817.1 mRNA 16 11 1756.022.4-B_at ⁇ 0.83558 0.83557952 14.58872 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 M63075.1 mRNA 1 15 1756.022.1-B_at ⁇ 0.82986 0.8298586 14.26541 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1
  • NM_000526.3 BM563823.1 EST 1 21 4629.020.1-F_at ⁇ 0.8194 0.81940128 13.71099 ⁇ 1e ⁇ 16 4629.020.
  • NM_022844.1 BI819760.1 EST 1 22 3861.001.1-B_at ⁇ 0.81782 0.8178189 13.63089 ⁇ 1e ⁇ 16 3861.001.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 24 1756.026.1-F_at ⁇ 0.81627 0.81626518 13.55314 ⁇ 1e ⁇ 16 1756.026.
  • NM_000109.2 M63075.1 mRNA 1 25 1756.022.2-T_at ⁇ 0.81571 0.815705 13.52532 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 26 1756.022.2-F_at ⁇ 0.81498 0.8149825 13.48962 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 27 3861.022.1-B_at ⁇ 0.81494 0.81494272 13.48766 ⁇ 1e ⁇ 16 3861.022.
  • NM_000526.3 BI085500.1 EST 1 28 3868.004.1-D_at ⁇ 0.81412 0.81412336 13.4474 ⁇ 1e ⁇ 16 3868.004.
  • NM_000526.3 BG677893.1 EST 1 32 1756.022.1-F_at ⁇ 0.81112 0.81111566 13.30165 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 33 1308.003.1-T_at ⁇ 0.80635 0.80635142 13.07706 ⁇ 1e ⁇ 16 1308.003.
  • NM_130778.1 NM_000494.2 REFSEQ 19 34 3868.005.1-B_at ⁇ 0.8061 0.80610095 13.06545 ⁇ 1e ⁇ 16 3868.005.
  • NM_005557.2 BG682632.1 EST 1 35 1308.007.1-F_at ⁇ 0.8044 0.80440011 12.98719 ⁇ 1e ⁇ 16 1308.007.
  • NM_130778.1 BF916393.1 EST 1 36 1308.009.1-F_at ⁇ 0.8039 0.80390038 12.96437 ⁇ 1e ⁇ 16 1308.009.
  • NM_130778.1 DA425187.1 EST 1 37 3861.007.1-E_at ⁇ 0.8038 0.80380368 12.95997 ⁇ 1e ⁇ 16 3861.007.
  • NM_000526.3 BG682207.1 EST 11 38 4629.016.1-D_at ⁇ 0.80378 0.80377953 12.95887 ⁇ 1e ⁇ 16 4629.016.
  • NM_022844.1 DB289769.1 EST 1 39 3084.007.1-F_at ⁇ 0.80131 0.80130924 12.84728 ⁇ 1e ⁇ 16 3084.007.
  • NM_022844.1 CQ717811.1 GENBANK_PATENT 1 44 4629.020.1-D_at ⁇ 0.78948 0.78947575 12.33726 ⁇ 1e ⁇ 16 4629.020.
  • NM_022844.1 BI819760.1 EST 1 45 5764.001.1-F_at ⁇ 0.78733 0.78733221 12.24894 ⁇ 1e ⁇ 16 5764.001.
  • NM_002825.5 AX135902.1
  • GENBANK_PATENT 3 46 3815.002.3-F_at ⁇ 0.78506 0.78505901 12.15655 ⁇ 1e ⁇ 16 3815.002.
  • NM_022844.1 AY520817.1 mRNA 16 49 128553.003.1-F ⁇ 0.78062 0.78061872 11.97975 ⁇ 1e ⁇ 16 128553.00 NM_173485.2 BP394387.1 EST 1 50 26289.003.1-F_at ⁇ 0.78004 0.78004 11.95705 ⁇ 1e ⁇ 16 26289.003 NM_174858.1 AK090967.1 mRNA 3 51 3815.002.2-F_at ⁇ 0.77826 0.77825678 11.88761 ⁇ 1e ⁇ 16 3815.002.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 52 1756.029.1-B_at ⁇ 0.77795 0.77795132 11.87578 ⁇ 1e ⁇ 16 1756.029.
  • NM_000109.2 BI551231.1 EST 1 53 4629.005.1-E_at ⁇ 0.7779 0.77790413 11.87396 ⁇ 1e ⁇ 16 4629.005.
  • NM_022844.1 CB963138.1 EST 3 54 4629.010.1-B_at ⁇ 0.77786 0.77786129 11.8723 ⁇ 1e ⁇ 16 4629.010.
  • NM_022844.1 AY520817.1 mRNA 16 63 23336.001.1-C_at ⁇ 0.76979 0.76978838 11.56754 ⁇ 1e ⁇ 16 23336.001
  • NM_145728.1 AJ697971.1 mRNA 1 64 1308.003.1-D_at ⁇ 0.76831 0.7683088 11.5132 ⁇ 1e ⁇ 16 1308.003.
  • NM_130778.1 NM_000494.2 REFSEQ 19 65 1756.022.3-T_at ⁇ 0.76731 0.76730759 11.47668 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 66 3861.020.1-T_at ⁇ 0.76715 0.76714705 11.47084 ⁇ 1e ⁇ 16 3861.020.
  • NM_000526.3 BM018298.1 EST 1 67 3861.022.1-C_at ⁇ 0.76448 0.76448457 11.37481 ⁇ 1e ⁇ 16 3861.022.
  • NM_000424.2 CQ733668.1 GENBANK_PATENT 1 69 26289.012.1-E_at ⁇ 0.76192 0.76191947 11.28361 ⁇ 1e ⁇ 16 26289.012 NM_174858.1 BG189938.1 EST 1 70 23336.003.1-T_at ⁇ 0.76122 0.76122392 11.2591 ⁇ 1e ⁇ 16 23336.003 NM_145728.1 CQ723645.1 GENBANK_PATENT 1 71 26289.007.1-B_at ⁇ 0.76082 0.76081931 11.24488 ⁇ 1e ⁇ 16 26289.007 NM_174858.1 DA259560.1 EST 1 72 84417.001.1-T_at ⁇ 0.76076 0.76075848 11.24275 ⁇ 1e ⁇ 16 84417.001 NM_032411.1 BI561114.1 EST 1 73 3861.018.1-D_at ⁇ 0.7605 0.76050387 11.23382 ⁇ 1e ⁇ 16 3
  • NM_000424.2 BE715131.1 EST 1 75 90865.006.1-B_at ⁇ 0.76035 0.76035315 11.22855 ⁇ 1e ⁇ 16 90865.006 NM_033439.2 AV707946.1 EST 1 76 4629.021.1-F_at ⁇ 0.76012 0.7601167 11.22027 ⁇ 1e ⁇ 16 4629.021.
  • NM_022844.1 CQ717811.1 GENBANK_PATENT 1 77 3861.018.1-T_at ⁇ 0.76002 0.76001693 11.21679 ⁇ 1e ⁇ 16 3861.018.
  • NM_000526.3 BM019687.1 EST 1 78 1756.022.1-T_at ⁇ 0.75998 0.75998388 11.21563 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 79 1264.003.1-B_at ⁇ 0.75956 0.75955538 11.20068 ⁇ 1e ⁇ 16 1264.003.
  • NM_001299.4 CV811526.1 EST 1 80 26289.010.1-E_at ⁇ 0.7591 0.75909546 11.18467 ⁇ 1e ⁇ 16 26289.010 NM_174858.1 AX988359.1 GENBANK_PATENT 1 81 3861.001.1-F_at ⁇ 0.75842 0.75842235 11.16131 ⁇ 1e ⁇ 16 3861.001. NM_000526.3 BG677893.1 EST 1 82 1908.002.1-T_at ⁇ 0.75841 0.75841175 11.16094 ⁇ 1e ⁇ 16 1908.002.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 86 1756.022.2-B_at ⁇ 0.75476 0.75476064 11.03568 ⁇ 1e ⁇ 16 1756.022.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 87 1756.027.1-B_at ⁇ 0.75441 0.75441365 11.0239 ⁇ 1e ⁇ 16 1756.027.
  • NM_000109.2 S60971.1 mRNA 1 88 3852.008.2-T_at ⁇ 0.75435 0.75434944 11.02172 ⁇ 1e ⁇ 16 3852.008.
  • NM_000526.3 BM018298.1 EST 1 97 1308.008.1-D_at ⁇ 0.7468 0.746803 10.77082 ⁇ 1e ⁇ 16 1308.008.
  • NM_000109.2 CQ714747.1 GENBANK_PATENT 1 101 79937.001.1-T_at ⁇ 0.74608 0.74607796 10.74722 ⁇ 1e ⁇ 16 79937.001 NM_033655.2 AF333769.2 mRNA 1 102 4915.012.1-E_at ⁇ 0.74575 0.74575052 10.73659 ⁇ 1e ⁇ 16 4915.012. NM_006180.3 CD103051.1 EST 1 103 3861.022.1-T_at ⁇ 0.74356 0.74356005 10.66593 ⁇ 1e ⁇ 16 3861.022.
  • NM_000902.2 A30431.1 GENBANK_PATENT 1 107 26289.006.1-T_at ⁇ 0.74283 0.74282989 10.64255 ⁇ 1e ⁇ 16 26289.006 NM_174858.1 CN356131.1 EST 1 108 5288.003.1-F_at ⁇ 0.74231 0.74231399 10.62608 ⁇ 1e ⁇ 16 5288.003. NM_004570.2 CQ721655.1 GENBANK_PATENT 1 109 4629.020.1-B_at ⁇ 0.7423 0.74230371 10.62575 ⁇ 1e ⁇ 16 4629.020.
  • NM_022844.1 BI819760.1 EST 1 110 26289.007.1-D_at ⁇ 0.74169 0.74168883 10.60617 ⁇ 1e ⁇ 16 26289.007 NM_174858.1 DA259560.1 EST 1 111 3815.002.1-B_at ⁇ 0.74167 0.74166962 10.60556 ⁇ 1e ⁇ 16 3815.002.
  • NM_053025.2 DR005817.1 EST 2 115 3084.008.1-F_at ⁇ 0.74052 0.74051659 10.56902 ⁇ 1e ⁇ 16 3084.008.
  • NM_013957.1 CQ733299.1
  • GENBANK_PATENT 1 116 4311.001.2-T_at ⁇ 0.73955 0.73955496 10.5387 ⁇ 1e ⁇ 16 4311.001.
  • NM_000902.2 CB988534.1 EST 1 117 3815.002.1-D_at ⁇ 0.73931 0.73930643 10.53089 ⁇ 1e ⁇ 16 3815.002.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 118 4629.020.1-T_at ⁇ 0.73906 0.73905518 10.523 ⁇ 1e ⁇ 16 4629.020.
  • NM_022844.1 BI819760.1 EST 1 119 1756.026.1-B_at ⁇ 0.739 0.73899721 10.52119 ⁇ 1e ⁇ 16 1756.026.
  • NM_000109.2 M63075.1 mRNA 1 120 3852.022.1-T_at ⁇ 0.73857 0.73856714 10.50771 ⁇ 1e ⁇ 16 3852.022.
  • NM_000424.2 BP226135.1 EST 1 121 4629.015.1-D_at ⁇ 0.73849 0.73848689 10.5052 ⁇ 1e ⁇ 16 4629.015.
  • NM_022844.1 DB284318.1 EST 1 122 26289.007.1-C_at ⁇ 0.73826 0.73825579 10.49797 ⁇ 1e ⁇ 16 26289.007 NM_174858.1 DA259560.1 EST 1 123 23194.003.1-C_at ⁇ 0.73638 0.73638084 10.43964 ⁇ 1e ⁇ 16 23194.003 NM_012304.3 BP290286.1 EST 1 124 3815.002.1-F_at ⁇ 0.73534 0.73534271 10.40757 ⁇ 1e ⁇ 16 3815.002.
  • NM_021110.1 CQ716670.1 GENBANK_PATENT 1 131 10010.002.1-E_at ⁇ 0.7322 0.73219822 10.31139 ⁇ 1e ⁇ 16 10010.002 NM_004180.2 CF242863.1 EST 1 132 59.026.1-B_at ⁇ 0.73215 0.73215036 10.30993 ⁇ 1e ⁇ 16 59.026.1 — — — — 133 4915.011.1-F_at ⁇ 0.73192 0.73191927 10.30292 ⁇ 1e ⁇ 16 4915.011.
  • NM_006180.3 CQ723929.1 GENBANK_PATENT 1 134 3872.007.1-D_at ⁇ 0.73192 0.73191502 10.30279 ⁇ 1e ⁇ 16 3872.007.
  • NM_000422.1 BU155457.1
  • EST 1 135 26289.002.1-D_at ⁇ 0.73171 0.73171045 10.2966 ⁇ 1e ⁇ 16 26289.002
  • NM_000109.2 NM_004016.1 REFSEQ 30 138 57447.033.1-C_at ⁇ 0.73085 0.73084864 10.27055 ⁇ 1e ⁇ 16 57447.033 NM_201535.1 DA135222.1 EST 1 139 26289.009.1-E_at ⁇ 0.7304 0.73039812 10.25697 ⁇ 1e ⁇ 16 26289.009 NM_174858.1 AA393277.1 EST 1 140 3872.006.1-F_at ⁇ 0.73024 0.73023988 10.25221 ⁇ 1e ⁇ 16 3872.006.
  • NM_022844.1 CB963138.1 EST 3 149 3815.002.1-T_at ⁇ 0.72727 0.72727235 10.16356 ⁇ 1e ⁇ 16 3815.002.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 150 23336.001.1-B_at ⁇ 0.72692 0.7269191 10.15309 ⁇ 1e ⁇ 16 23336.001
  • NM_022844.1 CB963138.1 EST 3 156 3872.009.1-T_at ⁇ 0.72329 0.72328551 10.04637 1E ⁇ 16 3872.009.
  • NM_000422.1 BX647923.1 mRNA 91 157 59.014.2-D_at ⁇ 0.72287 0.72287431 10.0344 1E ⁇ 16 59.014.2
  • NM_001613.1 CB962422.1
  • NM_003722.3 AB042841.1 mRNA 1 167 3815.002.4-T_at ⁇ 0.71955 0.71955195 9.938531 1E ⁇ 16 3815.002.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 168 84668.004.1-F_at ⁇ 0.71918 0.71917508 9.927746 1E ⁇ 16 84668.004 NM_032581.2 AL597549.1 EST 1 169 3872.007.1-F_at ⁇ 0.71916 0.71915759 9.927246 1E ⁇ 16 3872.007.
  • NM_000422.1 BU155457.1 EST 1 170 57447.031.1-E_at ⁇ 0.7189 0.71889801 9.919829 2E ⁇ 16 57447.031 NM_201535.1 AI272253.1 EST 1 171 3084.012.3-T_at ⁇ 0.71856 0.71855665 9.910088 2E ⁇ 16 3084.012. NM_013957.1 U02325.1 mRNA 1 172 3852.005.1-T_at ⁇ 0.71827 0.71827136 9.901958 2E ⁇ 16 3852.005.
  • NM_000424.2 R47851.1 EST 1 173 84417.001.2-T_at ⁇ 0.71816 0.71816117 9.898821 2E ⁇ 16 84417.001 NM_032411.1 BI561114.1 EST 1 174 3866.003.2-T_at ⁇ 0.71746 0.71745931 9.878874 2E ⁇ 16 3866.003. NM_002275.2 AK090604.1 mRNA 22 175 3866.008.1-C_at ⁇ 0.71716 0.71715783 9.870325 2E ⁇ 16 3866.008. NM_002275.2 BI771363.1 EST 1 176 3852.009.1-F_at ⁇ 0.71671 0.71671024 9.857654 2E ⁇ 16 3852.009.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 180 4281.010.1-B_at ⁇ 0.71619 0.71619361 9.84306 2E ⁇ 16 4281.010. NM_033290.1 AY540016.1 mRNA 1 181 59.008.1-B_at ⁇ 0.71578 0.7157817 9.831448 2E ⁇ 16 59.008.1 NM_001613.1 BP373197.1 EST 1 182 1264.007.1-T_at ⁇ 0.71577 0.71576716 9.831038 2E ⁇ 16 1264.007.
  • NM_001299.4 CX761868.1 EST 1 183 3868.004.1-T_at ⁇ 0.7156 0.71560057 9.826348 2E ⁇ 16 3868.004.
  • NM_005557.2 BM045170.1 EST 1 184 3084.002.1-F_at ⁇ 0.71513 0.71512815 9.813066 3E ⁇ 16 3084.002.
  • NM_013957.1 CN603657.1
  • NM_022844.1 AX898971.1 GENBANK_PATENT 1 187 4915.011.1-T_at ⁇ 0.71337 0.71336654 9.763782 3E ⁇ 16 4915.011.
  • NM_006180.3 CQ723929.1 GENBANK_PATENT 1 188 3852.013.1-E_at ⁇ 0.71333 0.71332619 9.762657 3E ⁇ 16 3852.013.
  • NM_001885.1 AX899079.1 GENBANK_PATENT 1 202 3866.009.2-D_at ⁇ 0.70722 0.70721526 9.594607 8E ⁇ 16 3866.009.
  • NM_002275.2 BI457146.1 EST 1 203 59.026.1-T_at ⁇ 0.70717 0.70717265 9.59345 8E ⁇ 16 59.026.1 — — — — 204 440421.001.1-T ⁇ 0.70711 0.70711453 9.591873 8E ⁇ 16 440421.00 XM_496202.2 XM_934894.1 REFSEQ 2 205 1756.022.4-D_at ⁇ 0.70675 0.70675086 9.582014 9E ⁇ 16 1756.022.
  • NM_003722.3 BG698723.1 EST 1 216 5288.001.1-B_at ⁇ 0.70452 0.70452172 9.521914 1E ⁇ 15 5288.001.
  • NM_004570.2 CQ720591.1 GENBANK_PATENT 1 217 72.001.1-B_at ⁇ 0.70441 0.70440953 9.518904 1E ⁇ 15 72.001.1 NM_001615.3 BP330025.1 EST 1 218 3866.006.2-D_at ⁇ 0.70383 0.70382789 9.503322 1E ⁇ 15 3866.006.
  • NM_002275.2 BQ641523.1 EST 1 219 3852.004.1-T_at ⁇ 0.70371 0.70371224 9.500228 1E ⁇ 15 3852.004.
  • NM_000424.2 BE715131.1 EST 1 220 4629.016.1-F_at ⁇ 0.70364 0.70363752 9.49823 1E ⁇ 15 4629.016.
  • NM_022844.1 DB289769.1 EST 1 221 4629.007.1-T_at ⁇ 0.70359 0.70358925 9.49694 1E ⁇ 15 4629.007.
  • NM_022844.1 AY520817.1 mRNA 16 222 65983.008.1-T_at ⁇ 0.70354 0.70353523 9.495496 1E ⁇ 15 65983.008 NM_023927.1 BI547735.1 EST 2 223 65983.013.1-F_at ⁇ 0.70278 0.7027824 9.475409 1E ⁇ 15 65983.013 NM_023927.1 AA610396.1 EST 1 224 3084.004.1-F_at ⁇ 0.70205 0.70204717 9.455852 2E ⁇ 15 3084.004.
  • NM_000422.1 BU155457.1 EST 1 261 2115.008.1-T_at ⁇ 0.69097 0.6909716 9.168257 6E ⁇ 15 2115.008.
  • BP262020.1 EST 1 263 57447.034.1-D_at ⁇ 0.69053 0.69052533 9.156935 7E ⁇ 15 57447.034 NM_201535.1 BC011240.1 mRNA 1 264 3866.001.1-F_at ⁇ 0.69016 0.69016212 9.147735 7E ⁇ 15 3866.001.
  • NM_002275.2 CQ733235.1 GENBANK_PATENT 23 265 3866.008.1-T_at ⁇ 0.69014 0.69014281 9.147247 7E ⁇ 15 3866.008.
  • NM_002275.2 BI771363.1 EST 1 266 1959.003.1-C_at ⁇ 0.68985 0.68984796 9.139789 7E ⁇ 15 1959.003.
  • NM_000399.2 BX414563.2 EST 3 267 389432.002.1-T ⁇ 0.68963 0.6896308 9.134301 8E ⁇ 15 389432.00 NM_001030060.
  • NM_004454.1 DB094869.1 EST 1 278 4638.006.2-F_at ⁇ 0.68764 0.6876412 9.084246 1E ⁇ 14 4638.006.
  • NM_053025.2 DR005817.1 EST 2 279 3866.007.2-D_at ⁇ 0.687 0.68699646 9.068108 1E ⁇ 14 3866.007.
  • NM_002275.2 BM548942.1 EST 1 280 59.014.1-T_at ⁇ 0.68691 0.68691236 9.066007 1E ⁇ 14 59.014.1
  • NM_001613.1 CB962422.1 EST 1 281 3866.001.2-F_at ⁇ 0.68681 0.68680934 9.063433 1E ⁇ 14 3866.001.
  • NM_002275.2 CQ733235.1 GENBANK_PATENT 23 282 1308.008.1-B_at ⁇ 0.68652 0.68652289 9.056281 1E ⁇ 14 1308.008.
  • NM_002275.2 BI457146.1 EST 1 291 4240.004.1-D_at ⁇ 0.68504 0.68503667 9.019305 1E ⁇ 14 4240.004.
  • NM_005928.1 BC003610.2 mRNA 448 292 3866.010.1-C_at ⁇ 0.68501 0.68500991 9.018641 1E ⁇ 14 3866.010.
  • NM_002275.2 BM045201.1 EST 1 293 3866.009.2-B_at ⁇ 0.68464 0.68464309 9.009548 1E ⁇ 14 3866.009.
  • NM_002275.2 BI457146.1 EST 1 294 3866.009.1-T_at ⁇ 0.68457 0.68456652 9.007652 1E ⁇ 14 3866.009.
  • NM_002275.2 BI457146.1 EST 1 295 4629.006.1-T_at ⁇ 0.68451 0.68450911 9.00623 1E ⁇ 14 4629.006.
  • NM_022844.1 DB079784.1 EST 1 296 7018.029.1-B_at ⁇ 0.68388 0.68388329 8.990755 2E ⁇ 14 7018.029.
  • NM_004684.2 CQ727530.1 GENBANK_PATENT 1 327 3860.007.1-D_at ⁇ 0.67955 0.67954786 8.884565 3E ⁇ 14 3860.007.
  • NM_002275.2 BI772438.1 EST 1 336 3852.017.1-D_at ⁇ 0.6775 0.67750467 8.835124 3E ⁇ 14 3852.017.
  • NM_000424.2 CV575305.1 EST 1 337 4915.005.1-T_at ⁇ 0.67735 0.67734733 8.831332 3E ⁇ 14 4915.005.
  • NM_006180.3 BP348402.1 EST 1 338 4638.003.1-B_at ⁇ 0.67707 0.67706981 8.82465 3E ⁇ 14 4638.003.
  • NM_053025.2 BP289609.1 EST 2 339 1756.003.1-B_at ⁇ 0.67674 0.67673545 8.816608 4E ⁇ 14 1756.003.
  • NM_000109.2 AB208836.1 mRNA 1 340 4638.006.1-F_at ⁇ 0.67651 0.6765092 8.811172 4E ⁇ 14 4638.006.
  • NM_053025.2 DR005817.1
  • EST 2 341 57447.035.1-F_at ⁇ 0.67604 0.67604162 8.799953 4E ⁇ 14 57447.035
  • NM_201535.1 BQ636638.1 EST 1 342 4638.014.1-T_at ⁇ 0.67585 0.67584646 8.795276 4E ⁇ 14 4638.014.
  • NM_053025.2 DB267860.1 EST 1 350 7373.002.1-F_at ⁇ 0.67455 0.67455304 8.764365 5E ⁇ 14 7373.002.
  • NM_002275.2 BI769443.1 EST 1 352 5608.002.1-T_at ⁇ 0.67444 0.67443693 8.761597 5E ⁇ 14 5608.002.
  • NM_002758.2 DA427998.1 EST 1 353 3866.001.1-C_at ⁇ 0.67411 0.67411218 8.753863 5E ⁇ 14 3866.001.
  • NM_002275.2 CQ733235.1
  • GENBANK_PATENT 23 354 1756.013.1-B_at ⁇ 0.67402 0.67402382 8.75176 5E ⁇ 14 1756.013.
  • REFSEQ 2 355 2115.006.1-E_at ⁇ 0.67381 0.67381491 8.746791 5E ⁇ 14 2115.006.
  • NM_013957.1 NM_013964.1 REFSEQ 5 358 3815.002.4-F_at ⁇ 0.67334 0.67333838 8.735471 5E ⁇ 14 3815.002.
  • NM_001299.4 CN366945.1 EST 1 361 59.022.2-D_at ⁇ 0.67316 0.67315986 8.731236 5E ⁇ 14 59.022.2 — — — — 362 25925.001.1-T_at ⁇ 0.67306 0.67306029 8.728874 5E ⁇ 14 25925.001 NM_015461.1 BC032869.2 mRNA 19 363 4638.006.2-B_at ⁇ 0.67278 0.67278344 8.722314 6E ⁇ 14 4638.006. NM_053025.2 DR005817.1 EST 2 364 7373.003.5-B_at ⁇ 0.67271 0.67270981 8.72057 6E ⁇ 14 7373.003.
  • NM_004684.2 BG716198.1 EST 1 366 59.012.1-T_at ⁇ 0.67254 0.67254112 8.716577 6E ⁇ 14 59.012.1
  • NM_000902.2 A30431.1 GENBANK_PATENT 1 372 59.031.2-T_at ⁇ 0.67084 0.67084085 8.676467 7E ⁇ 14 59.031.2 NM_001613.1 BG197213.1 EST 19 373 4311.009.1-T_at ⁇ 0.67054 0.67053973 8.669389 7E ⁇ 14 4311.009. NM_000902.2 A30431.1 GENBANK_PATENT 1 374 3866.006.2-B_at ⁇ 0.67045 0.67044748 8.667223 7E ⁇ 14 3866.006.
  • NM_001360.1 BX438503.2 EST 1 377 59.004.2-D_at ⁇ 0.67008 0.67008376 8.658687 8E ⁇ 14 59.004.2
  • NM_001613.1 CQ696293.1 GENBANK_PATENT 1 378 3866.007.2-B_at ⁇ 0.66995 0.66994537 8.655442 8E ⁇ 14 3866.007.
  • NM_002275.2 BM548942.1 EST 1 379 3866.010.1-F_at ⁇ 0.66945 0.66944797 8.643794 8E ⁇ 14 3866.010.
  • NM_002275.2 BM045201.1 EST 1 380 9768.004.1-D_at 0.669331 0.66933125 8.641063 8E ⁇ 14 9768.004.
  • NM_001460.2 CD684429.1 EST 1 386 1308.004.1-B_at ⁇ 0.66865 0.66864754 8.625092 9E ⁇ 14 1308.004.
  • NM_130778.1 BE615666.1 EST 1 387 2568.005.2-B_at ⁇ 0.66838 0.66838113 8.61888 9E ⁇ 14 2568.005.
  • NM_014211.1 AK055205.1 mRNA 11 388 2568.001.1-T_at ⁇ 0.66811 0.66811257 8.612624 9E ⁇ 14 2568.001.
  • NM_014211.1 BX509618.1 EST 1 389 3084.004.2-T_at ⁇ 0.66789 0.66788994 8.607442 1E ⁇ 13 3084.004.
  • NM_013957.1 NM_013964.1 REFSEQ 5 390 7373.003.4-B_at ⁇ 0.66777 0.66776994 8.604651 1E ⁇ 13 7373.003.
  • NM_021110.1 CQ716670.1 GENBANK_PATENT 1 391 7153.002.2-D_at 0.667642 0.66764203 8.601677 1E ⁇ 13 7153.002.
  • NM_001067.2 CQ735949.1
  • GENBANK_PATENT 114 392 2893.006.2-T_at ⁇ 0.66761 0.66760773 8.600879 1E ⁇ 13 2893.006.
  • NM_000829.1 BF669210.1 EST 1 393 3872.016.1-D_at ⁇ 0.66759 0.66758641 8.600384 1E ⁇ 13 3872.016.
  • NM_000422.1 CB127430.1 EST 1 394 9413.006.1-F_at ⁇ 0.6674 0.6674036 8.596137 1E ⁇ 13 9413.006.
  • NM_006180.3 CQ723929.1 GENBANK_PATENT 1 398 27122.018.1-F_at ⁇ 0.66662 0.6666247 8.578072 1E ⁇ 13 27122.018 NM_013253.4 BG715341.1 EST 1 399 3852.006.1-B_at ⁇ 0.66652 0.66652184 8.57569 1E ⁇ 13 3852.006.
  • NM_000424.2 BG679014.1 EST 1 400 4638.006.2-D_at ⁇ 0.66649 0.66648584 8.574857 1E ⁇ 13 4638.006.
  • NM_053025.2 DR005817.1 EST 2 401 7153.005.1-E_at 0.666056 0.66605623 8.56492 1E ⁇ 13 7153.005.
  • NM_001067.2 DB061604.1
  • EST 1 402 7373.001.2-T_at ⁇ 0.66587 0.66587031 8.560624 1E ⁇ 13 7373.001.
  • NM_053025.2 AX885051.1 GENBANK_PATENT 39 419 3861.023.1-T_at ⁇ 0.66279 0.66279224 8.489919 2E ⁇ 13 3861.023.
  • NM_000526.3 BG676679.1
  • EST 1 420 5858.003.3-C_at ⁇ 0.66243 0.66242627 8.481564 2E ⁇ 13 5858.003.
  • NM_002864.1 AX512279.1 GENBANK_PATENT 2 421 3861.020.1-F_at ⁇ 0.66242 0.66241661 8.481344 2E ⁇ 13 3861.020.
  • NM_006180.3 NM_001018066 REFSEQ 28 426 3866.008.1-B_at ⁇ 0.66173 0.66172906 8.465676 2E ⁇ 13 3866.008.
  • NM_002275.2 BI771363.1 EST 1 427 8626.002.1-E_at ⁇ 0.66173 0.66172521 8.465589 2E ⁇ 13 8626.002.
  • NM_003722.3 AB016072.1 mRNA 16 428 1264.003.1-T_at ⁇ 0.66156 0.66156109 8.461855 2E ⁇ 13 1264.003.
  • NM_001299.4 CV811526.1 EST 1 429 59.042.1-F_at ⁇ 0.66151 0.66151227 8.460744 2E ⁇ 13 59.042.1 NM_001613.1 EH_001613.8 PREDICTED 1 430 4833.004.1-C_at 0.661269 0.66126853 8.455204 2E ⁇ 13 4833.004.
  • NM_005009.2 BG478602.1 EST 8 431 2568.006.1-B_at ⁇ 0.66106 0.661057 8.450399 2E ⁇ 13 2568.006.
  • NM_000424.2 CQ733668.1 GENBANK_PATENT 1 437 59.033.1-T_at ⁇ 0.66029 0.66028879 8.43298 2E ⁇ 13 59.033.1 — — — — 438 27122.002.1-C_at ⁇ 0.66018 0.66018203 8.430563 2E ⁇ 13 27122.002 NM_013253.4 AK098756.1 mRNA 1 439 3880.011.1-B_at ⁇ 0.65981 0.65981353 8.422227 2E ⁇ 13 3880.011.
  • NM_023927.1 DB261377.1 EST 1 447 7373.003.5-F_at ⁇ 0.65893 0.65892789 8.402237 3E ⁇ 13 7373.003.
  • NM_001360.1 DB170498.1 EST 1 460 1756.027.1-F_at ⁇ 0.65672 0.6567193 8.352655 3E ⁇ 13 1756.027.
  • NM_000109.2 S60971.1 mRNA 1 461 59.042.1-B_at ⁇ 0.65672 0.65671619 8.352585 3E ⁇ 13 59.042.1 NM_001613.1 EH_001613.8 PREDICTED 1 462 7153.002.5-D_at 0.656687 0.65668727 8.351939 3E ⁇ 13 7153.002.
  • GENBANK_PATENT 114 463 57447.031.1-F_at ⁇ 0.6565 0.65650401 8.347842 3E ⁇ 13 57447.031 NM_201535.1 AI272253.1 EST 1 464 140885.011.1-C ⁇ 0.65642 0.6564245 8.346065 3E ⁇ 13 140885.01 NM_080792.2 BM041242.1 EST 1 465 59.003.1-T_at ⁇ 0.65633 0.65632979 8.34395 3E ⁇ 13 59.003.1 NM_001613.1 DD218797.1 GENBANK_PATENT 1 466 3832.002.1-D_at 0.655783 0.65578291 8.331747 4E ⁇ 13 3832.002.
  • NM_004523.2 BQ959682.1 EST 1 467 3880.005.1-D_at ⁇ 0.65576 0.65576275 8.331298 4E ⁇ 13 3880.005.
  • NM_002276.3 BE732853.1 EST 1 468 3084.012.1-F_at ⁇ 0.65533 0.65532867 8.32163 4E ⁇ 13 3084.012.
  • NM_053025.2 NM_053029.2 REFSEQ 2 490 6376.001.1-T_at ⁇ 0.65101 0.6510092 8.226201 6E ⁇ 13 6376.001.
  • NM_001063.2 BM690655.1 EST 1 498 7018.028.1-E_at ⁇ 0.64913 0.64913076 8.185136 7E ⁇ 13 7018.028.
  • NM_006180.3 NM_001007097 REFSEQ 4 500 358.018.1-C_at ⁇ 0.64903 0.64902608 8.182855 7E ⁇ 13 358.018.1 NM_198098.1 BI765065.1 EST 1 501 7153.002.6-B_at 0.648669 0.64866924 8.175087 8E ⁇ 13 7153.002.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 502 57447.012.1-T_at ⁇ 0.6478 0.64780212 8.156247 9E ⁇ 13 57447.012 NM_201535.1 DB294263.1 EST 1 503 59.040.1-B_at ⁇ 0.6477 0.64769503 8.153924 9E ⁇ 13 59.040.1 NM_001613.1 EH_001613.6 PREDICTED 1 504 57447.006.1-T_at ⁇ 0.64719 0.64718891 8.142957 9E ⁇ 13 57447.006 NM_201535.1 DA283861.1 EST 4 505 9493.006.1-F_at 0.646558 0.64655811 8.129315 1E ⁇ 12 9493.006.
  • NM_005009.2 BG478602.1 EST 8 526 3426.001.1-F_at ⁇ 0.64388 0.64388211 8.071756 1E ⁇ 12 3426.001.
  • NM_000204.1 BC020718.1 mRNA 165 527 59.034.1-B_at ⁇ 0.64382 0.64381551 8.07033 1E ⁇ 12 59.034.1 — — — — 528 10253.001.1-E_at ⁇ 0.64381 0.64381114 8.070237 1E ⁇ 12 10253.001
  • NM_005842.2 BE297407.1 EST 1 529 9073.001.1-C_at ⁇ 0.64379 0.64379361 8.069862 1E ⁇ 12 9073.001.
  • BX480398.1 EST 1 542 358.012.1-B_at ⁇ 0.6417 0.6417015 8.025228 2E ⁇ 12 358.012.1 NM_198098.1
  • NM_033290.1 AY539998.1 mRNA 1 550 10144.020.2-B_at ⁇ 0.64053 0.64053304 8.000433 2E ⁇ 12 10144.020 NM_014883.2 DA864231.1 EST 1 551 6876.016.1-E_at ⁇ 0.64047 0.64046896 7.999075 2E ⁇ 12 6876.016. NM_001001522.
  • NM_002275.2 CQ733235.1 GENBANK_PATENT 23 560 55107.006.2-T_at ⁇ 0.63865 0.63864972 7.960666 2E ⁇ 12 55107.006 NM_018043.4 CQ722042.1 GENBANK_PATENT 1 561 79068.010.1-D_at ⁇ 0.63836 0.63836198 7.954611 2E ⁇ 12 79068.010 XM_051200.8 DA647247.1 EST 1 562 57447.009.1-T_at ⁇ 0.63836 0.63835821 7.954532 2E ⁇ 12 57447.009 NM_201535.1 BI550962.1 EST 1 563 2115.015.1-T_at ⁇ 0.638 0.63799997 7.947002 2E ⁇ 12 2115.0
  • NM_004956.3 DA220931.1 EST 1 564 1756.013.1-C_at ⁇ 0.638 0.63799967 7.946996 2E ⁇ 12 1756.013.
  • NM_000109.2 NM_004019.1
  • REFSEQ 2 565 7169.015.1-F_at ⁇ 0.63796 0.63796151 7.946194 2E ⁇ 12 7169.015.
  • NM_213674.1 DB291177.1 EST 1 566 65983.013.2-F_at ⁇ 0.63792 0.63792448 7.945416 2E ⁇ 12 65983.013 NM_023927.1 AA610396.1 EST 1 567 8404.001.1-B_at ⁇ 0.63758 0.63757819 7.938148 2E ⁇ 12 8404.001. NM_004684.2 DA132781.1 EST 1 568 4240.004.1-B_at ⁇ 0.63705 0.6370484 7.927043 3E ⁇ 12 4240.004.
  • NM_004684.2 BX463355.2 EST 1 584 3426.002.1-D_at ⁇ 0.63533 0.63533255 7.891208 3E ⁇ 12 3426.002.
  • NM_000204.1 CQ718881.1 GENBANK_PATENT 1 585 2335.027.1-T_at 0.635297 0.63529691 7.890465 3E ⁇ 12 2335.027.
  • NM_006206.3 BP336054.1 EST 1 598 5858.004.1-E_at ⁇ 0.63354 0.63353969 7.853973 4E ⁇ 12 5858.004.
  • NM_002864.1 DB033417.1 EST 1 599 25802.008.1-D_at ⁇ 0.63342 0.63342256 7.851548 4E ⁇ 12 25802.008
  • NM_012134.1 DA767597.1
  • NM_001460.2 CD684429.1 EST 1 601 3852.004.1-C_at ⁇ 0.63298 0.63298294 7.842454 4E ⁇ 12 3852.004.
  • NM_004684.2 CQ498058.1 GENBANK_PATENT 1 612 84441.002.1-E_at ⁇ 0.63188 0.63188122 7.819718 4E ⁇ 12 84441.002 NM_032427.1 CQ739825.1 GENBANK_PATENT 1 613 2.013.1-E_at ⁇ 0.63181 0.63181031 7.818258 4E ⁇ 12 2.013.1 NM_000014.4 DA467444.1 EST 1 614 3084.004.1-T_at ⁇ 0.63137 0.63136737 7.809141 4E ⁇ 12 3084.004.
  • NM_000222.1 CQ719901.1 GENBANK_PATENT 1 621 1756.009.1-D_at ⁇ 0.63082 0.63082241 7.797942 5E ⁇ 12 1756.009.
  • NM_000109.2 NM_004023.1 REFSEQ 1 622 7091.014.1-B_at ⁇ 0.63047 0.63046815 7.790673 5E ⁇ 12 7091.014.
  • NM_033290.1 AY539999.1 mRNA 1 628 84668.002.2-T_at ⁇ 0.62976 0.62975676 7.776099 5E ⁇ 12 84668.002 NM_032581.2 AL833296.1 mRNA 20 629 4240.004.1-F_at ⁇ 0.6295 0.62950111 7.77087 5E ⁇ 12 4240.004. NM_005928.1 BC003610.2 mRNA 448 630 8404.005.1-D_at ⁇ 0.62918 0.62917718 7.76425 6E ⁇ 12 8404.005.
  • NM_004684.2 DA763956.1 EST 1 631 8404.032.1-B_at ⁇ 0.62902 0.62902338 7.761109 6E ⁇ 12 8404.032.
  • NM_004684.2 CQ498058.1 GENBANK_PATENT 1 632 57447.044.1-E_at ⁇ 0.6289 0.62890008 7.758592 6E ⁇ 12 57447.044 NM_201535.1 DB232855.1 EST 1 633 8626.006.2-F_at ⁇ 0.62867 0.6286676 7.753849 6E ⁇ 12 8626.006.
  • NM_000204.1 CQ718881.1 GENBANK_PATENT 1 637 1308.001.1-T_at ⁇ 0.62793 0.62793498 7.738925 6E ⁇ 12 1308.001. NM_130778.1 BM773425.1 EST 1 638 389432.002.1-F ⁇ 0.62759 0.62758948 7.731899 6E ⁇ 12 389432.00 NM_001030060.
  • NM_002644.2 DB225999.1 EST 1 642 57447.029.1-F_at ⁇ 0.62716 0.6271633 7.723242 7E ⁇ 12 57447.029 NM_201535.1
  • BX354120.2 EST 6 643 8626.006.1-F_at ⁇ 0.62697 0.62697054 7.71933 7E ⁇ 12 8626.006.
  • NM_003722.3 CB049427.1 EST 1 644 2982.002.1-C_at ⁇ 0.62686 0.62686245 7.717138 7E ⁇ 12 2982.002.
  • NM_053025.2 DA694890.1 EST 1 662 57447.017.1-C_at ⁇ 0.62424 0.62423695 7.664109 9E ⁇ 12 57447.017 NM_201535.1 DA130260.1 EST 1 663 7373.004.1-T_at ⁇ 0.62423 0.6242336 7.664041 9E ⁇ 12 7373.004.
  • NM_000424.2 BG675837.1 EST 1 665 4281.015.1-E_at ⁇ 0.62376 0.62376072 7.654536 9E ⁇ 12 4281.015.
  • NM_004454.1 BU197295.1 EST 1 679 7373.003.6-F_at ⁇ 0.6217 0.62170218 7.613316 1E ⁇ 11 7373.003.
  • NM_021110.1 CQ716670.1 GENBANK_PATENT 1 680 79608.008.1-T_at ⁇ 0.6214 0.62140438 7.607374 1E ⁇ 11 79608.008 NM_024557.2 DA748988.1 EST 2 681 3852.008.1-T_at ⁇ 0.62129 0.62128908 7.605075 1E ⁇ 11 3852.008.
  • NM_000424.2 BG675837.1 EST 1 682 8626.007.1-T_at ⁇ 0.62113 0.62113254 7.601955 1E ⁇ 11 8626.007.
  • NM_003722.3 BG698723.1 EST 1 683 8404.022.1-T_at ⁇ 0.62104 0.62103797 7.60007 1E ⁇ 11 8404.022.
  • NM_004684.2 BP311988.1 EST 1 684 8404.034.1-T_at ⁇ 0.62101 0.62101196 7.599552 1E ⁇ 11 8404.034.
  • NM_004684.2 DA148306.1 EST 1 685 57447.049.1-T_at ⁇ 0.62097 0.62096556 7.598628 1E ⁇ 11 57447.049 NM_201535.1 DB180733.1 EST 1 686 5311.002.1-B_at ⁇ 0.62092 0.62092128 7.597746 1E ⁇ 11 5311.002. NM_000297.2 CQ727531.1 GENBANK_PATENT 1 687 2335.025.3-T_at 0.620916 0.62091648 7.597651 1E ⁇ 11 2335.025.
  • NM_000204.1 CQ718881.1 GENBANK_PATENT 1 692 7091.001.1-C_at ⁇ 0.62037 0.62037055 7.586788 1E ⁇ 11 7091.001.
  • NM_007005.3 BC045650.1 mRNA 17 693 8404.021.1-D_at ⁇ 0.62032 0.6203222 7.585827 1E ⁇ 11 8404.021.
  • NM_004684.2 DA291834.1 EST 1 694 7153.002.3-B_at 0.620304 0.62030417 7.585469 1E ⁇ 11 7153.002.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 695 53335.002.1-E_at ⁇ 0.62026 0.62026302 7.584651 1E ⁇ 11 53335.002 NM_018014.2 BU159551.1 EST 1 696 5284.003.2-T_at ⁇ 0.62002 0.62001653 7.579754 1E ⁇ 11 5284.003. NM_002644.2 BP220016.1 EST 1 697 4306.002.1-F_at ⁇ 0.61996 0.61995574 7.578547 1E ⁇ 11 4306.002.
  • NM_022844.1 DB289769.1 EST 1 707 6876.002.1-C_at ⁇ 0.61913 0.61912596 7.562091 1E ⁇ 11 6876.002. NM_001001522. DB262921.1 EST 1 708 65983.007.1-T_at ⁇ 0.61906 0.61905788 7.560743 1E ⁇ 11 65983.007 NM_023927.1 DA388235.1 EST 1 709 7373.003.2-F_at ⁇ 0.61891 0.61891452 7.557905 1E ⁇ 11 7373.003.
  • NM_021110.1 CQ716670.1 GENBANK_PATENT 1 710 152015.004.1-T ⁇ 0.61872 0.61872078 7.554071 2E ⁇ 11 152015.00 NM_001012337.
  • NM_033290.1 AY540014.1 mRNA 1 728 4094.001.1-T_at ⁇ 0.61638 0.61638223 7.507972 2E ⁇ 11 4094.001.
  • NM_005360.3 REFSEQ 17 729 2995.001.1-T_at ⁇ 0.61614 0.6161404 7.503223 2E ⁇ 11 2995.001.
  • NM_002101.3 CQ729268.1 GENBANK_PATENT 1 730 4638.011.1-T_at ⁇ 0.61607 0.61606684 7.501779 2E ⁇ 11 4638.011.
  • NM_007005.3 AL551038.3 EST 1 739 8404.008.1-C_at ⁇ 0.61554 0.61554203 7.491488 2E ⁇ 11 8404.008.
  • NM_004684.2 DA342341.1 EST 1 740 6376.001.2-C_at ⁇ 0.61538 0.61538183 7.488349 2E ⁇ 11 6376.001.
  • NM_021110.1 CQ656872.1 GENBANK_PATENT 1 748 4744.004.1-C_at ⁇ 0.61432 0.61431915 7.467569 2E ⁇ 11 4744.004.
  • NM_021076.2 BQ636126.1 EST 1 749 140885.010.1-T ⁇ 0.61432 0.61431838 7.467554 2E ⁇ 11 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1 750 6876.016.2-E_at ⁇ 0.61423 0.61422523 7.465735 2E ⁇ 11 6876.016.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 771 2568.003.1-T_at ⁇ 0.61165 0.61164713 7.415606 3E ⁇ 11 2568.003.
  • NM_014211.1 CD696885.1
  • NM_001613.1 BP373197.1 EST 1 773 9898.015.2-B_at 0.611466 0.61146611 7.4121 3E ⁇ 11 9898.015.
  • NM_002644.2 AX012182.1 GENBANK_PATENT 1 778 2.002.1-C_at ⁇ 0.61064 0.61064092 7.396143 3E ⁇ 11 2.002.1 NM_000014.4 CQ672194.1
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 796 3852.023.1-T_at ⁇ 0.60821 0.60820967 7.349352 4E ⁇ 11 3852.023.
  • NM_000424.2 BG681715.1 EST 1 797 8404.013.1-F_at ⁇ 0.60812 0.60812437 7.347716 4E ⁇ 11 8404.013.
  • NM_153649.2 BQ959117.1
  • EST 1 805 54928.003.1-E_at ⁇ 0.60719 0.60719005 7.329827 4E ⁇ 11 54928.003
  • NM_017813.2 DB283344.1 EST 1 806 2335.025.1-B_at 0.607111 0.60711088 7.328313 4E ⁇ 11 2335.025.
  • NM_212482.1 CQ715726.1
  • GENBANK_PATENT 3 807 3084.010.1-T_at ⁇ 0.60698 0.60697967 7.325805 4E ⁇ 11 3084.010.
  • NM_014211.1 AK055205.1 mRNA 11 811 8404.032.1-F_at ⁇ 0.60677 0.60676941 7.321788 5E ⁇ 11 8404.032.
  • NM_004684.2 CQ498058.1 GENBANK_PATENT 1 812 2115.003.1-E_at ⁇ 0.60663 0.60662753 7.319079 5E ⁇ 11 2115.003.
  • NM_004684.2 CQ727530.1 GENBANK_PATENT 1 816 6289.003.1-B_at ⁇ 0.60525 0.60524909 7.292816 5E ⁇ 11 6289.003.
  • NM_030754.2 R83510.1 EST 1 817 7170.025.1-F_at 0.604985 0.6049846 7.287789 5E ⁇ 11 7170.025.
  • NM_153649.2 BE208737.1 EST 1 818 8404.030.1-D_at ⁇ 0.60498 0.60498368 7.287771 5E ⁇ 11 8404.030.
  • NM_000204.1 CQ718881.1 GENBANK_PATENT 1 823 4638.003.1-D_at ⁇ 0.60438 0.60437577 7.276231 6E ⁇ 11 4638.003.
  • NM_053025.2 BP289609.1
  • EST 2 824 4147.011.1-T_at ⁇ 0.6043 0.60430187 7.274829 6E ⁇ 11 4147.011.
  • NM_004684.2 DA291834.1 EST 1 833 25925.011.1-E_at ⁇ 0.60378 0.6037774 7.264891 6E ⁇ 11 25925.011 NM_015461.1 DA105762.1 EST 1 834 23266.001.3-F_at ⁇ 0.60352 0.60352263 7.260069 6E ⁇ 11 23266.001 NM_012302.2 AK123422.1 mRNA 2 835 9232.004.1-F_at 0.603479 0.60347894 7.259242 6E ⁇ 11 9232.004. NM_004219.2 BF983295.1 EST 1 836 4147.005.2-F_at ⁇ 0.60347 0.60346555 7.258989 6E ⁇ 11 4147.005.
  • NM_053025.2 DR005817.1 EST 2 839 147804.004.1-T 0.603318 0.60331792 7.256196 6E ⁇ 11 147804.00 NM_001010856.
  • GENBANK_PATENT 114 849 1063.002.1-F_at 0.602485 0.60248476 7.24046 7E ⁇ 11 1063.002.
  • GENBANK_PATENT 1 850 10144.021.1-F_at ⁇ 0.60221 0.60221389 7.235351 7E ⁇ 11 10144.021 NM_014883.2 BG434219.1
  • NM_004684.2 DB086831.1 EST 1 852 6876.020.1-B_at ⁇ 0.60216 0.60215903 7.234317 7E ⁇ 11 6876.020.
  • NM_001001522. BM921237.1 EST 1 853 7170.006.1-C_at 0.601994 0.6019941 7.231209 7E ⁇ 11 7170.006.
  • NM_153649.2 DB003864.1 EST 1 854 10051.016.1-T_at 0.601783 0.60178293 7.227232 7E ⁇ 11 10051.016 NM_001002799.
  • NM_014211.1 AK055205.1 mRNA 11 877 10051.005.3-T_at 0.599532 0.59953164 7.184979 9E ⁇ 11 10051.005 NM_001002799.
  • BU183025.1 EST 1 878 2568.002.2-T_at ⁇ 0.59944 0.59943802 7.183228 9E ⁇ 11 2568.002.
  • NM_014211.1 DB235581.1 EST 1 879 4147.004.1-F_at ⁇ 0.59921 0.59921316 7.179023 9E ⁇ 11 4147.004.
  • NM_002497.2 BI464450.1 EST 1 890 64151.001.2-T_at 0.597704 0.59770416 7.150876 1E ⁇ 10 64151.001 NM_022346.3 CQ729716.1 GENBANK_PATENT 2 891 29089.003.1-T_at 0.597695 0.59769515 7.150708 1E ⁇ 10 29089.003 NM_014176.1 AV740591.1 EST 1 892 59.031.1-B_at ⁇ 0.59762 0.59761835 7.149279 1E ⁇ 10 59.031.1 NM_001613.1 BG197213.1 EST 19 893 7018.025.1-T_at ⁇ 0.59758 0.59757801 7.148528 1E ⁇ 10 7018.025.
  • NM_213674.1 BG385598.1 EST 1 898 25925.006.1-T_at ⁇ 0.59714 0.59714283 7.140436 1E ⁇ 10 25925.006 NM_015461.1 DB276803.1 EST 1 899 59.049.1-F_at ⁇ 0.59713 0.59712525 7.140109 1E ⁇ 10 59.049.1 — — — — 900 5284.003.1-T_at ⁇ 0.59709 0.59708796 7.139416 1E ⁇ 10 5284.003.
  • NM_003380.2 BE728213.1 EST 1 913 8404.029.1-E_at ⁇ 0.5957 0.59569505 7.113583 1E ⁇ 10 8404.029.
  • NM_004684.2 AA384658.1 EST 1 914 6876.020.1-T_at ⁇ 0.59541 0.59541268 7.108359 1E ⁇ 10 6876.020.
  • BM921237.1 EST 1 915 301.005.1-T_at ⁇ 0.59539 0.59538592 7.107864 1E ⁇ 10 301.005.1
  • NM_000700.1 AU139656.1 EST 7 916 9055.014.1-T_at 0.59529 0.5952897 7.106085 1E ⁇ 10 9055.014.
  • NM_003981.2 BE300335.1 EST 1 917 4281.023.1-T_at ⁇ 0.5952 0.59520125 7.104449 1E ⁇ 10 4281.023.
  • NM_033290.1 AY539976.1 mRNA 1 918 3868.005.1-D_at ⁇ 0.59519 0.59519189 7.104276 1E ⁇ 10 3868.005.
  • NM_005557.2 BG682632.1 EST 1 919 1062.001.6-B_at 0.595002 0.59500239 7.100775 1E ⁇ 10 1062.001.
  • NM_001813.2 CQ715352.1 GENBANK_PATENT 1 920 5858.005.1-T_at ⁇ 0.59493 0.5949259 7.099362 1E ⁇ 10 5858.005.
  • NM_005928.1 BF525404.1 EST 1 923 8404.029.1-T_at ⁇ 0.59477 0.59477341 7.096546 1E ⁇ 10 8404.029.
  • NM_014736.4 BG529193.1 EST 13 926 11197.001.1-T_at ⁇ 0.59454 0.59454222 7.092279 1E ⁇ 10 11197.001 NM_007191.2 W37154.1 EST 1 927 6285.002.1-T_at ⁇ 0.59451 0.59450684 7.091626 1E ⁇ 10 6285.002. NM_006272.1 BQ435930.1 EST 1 928 2335.006.2-F_at 0.594359 0.59435947 7.088907 1E ⁇ 10 2335.006. NM_212482.1 CX785805.1 EST 1 929 7169.001.1-C_at ⁇ 0.59424 0.59424202 7.086742 1E ⁇ 10 7169.001.
  • NM_002417.2 BG106198.1 EST 1 935 8321.004.1-D_at ⁇ 0.59365 0.59365154 7.075865 1E ⁇ 10 8321.004.
  • NM_003505.1 AA249884.1 EST 1 936 8564.004.1-E_at ⁇ 0.59345 0.59344954 7.072148 1E ⁇ 10 8564.004.
  • NM_003679.2 AV646525.1 EST 3 937 7169.022.1-C_at ⁇ 0.59343 0.59343079 7.071803 1E ⁇ 10 7169.022.
  • NM_213674.1 BG385598.1 EST 1 938 29127.013.1-T_at 0.593386 0.59338577 7.070975 1E ⁇ 10 29127.013 NM_013277.2 DA812983.1 EST 1 939 2.018.1-B_at ⁇ 0.59317 0.59316746 7.066961 1E ⁇ 10 2.018.1 NM_000014.4 DB090657.1 EST 1 940 2.005.1-D_at ⁇ 0.59314 0.59313787 7.066417 1E ⁇ 10 2.005.1 NM_000014.4 BI493707.1 EST 1 941 1058.004.2-T_at 0.5931 0.59310026 7.065726 2E ⁇ 10 1058.004.
  • NM_000618.2 U40870.1 mRNA 4 950 94274.003.1-D_at ⁇ 0.59243 0.59242603 7.053346 2E ⁇ 10 94274.003 NM_033256.1 AB056509.1 mRNA 1 951 84668.003.1-T_at ⁇ 0.59229 0.5922945 7.050934 2E ⁇ 10 84668.003 NM_032581.2 CQ727246.1 GENBANK_PATENT 1 952 22974.008.1-E_at 0.592131 0.59213066 7.04793 2E ⁇ 10 22974.008 NM_012112.4 CQ727779.1 GENBANK_PATENT 1 953 55656.007.3-B_at 0.592104 0.59210361 7.047434 2E ⁇ 10 55656.007 NM_017864.2 CQ715091.1 GENBANK_PATENT 1 954 29127.002.1-T_at 0.591958 0.59195836 7.044773 2
  • NM_033290.1 CN298826.1 EST 1 956 2335.013.1-B_at 0.591874 0.59187364 7.043221 2E ⁇ 10 2335.013.
  • NM_212482.1 AL551632.3 EST 2 957 79627.003.1-B_at ⁇ 0.59185 0.59184571 7.042709 2E ⁇ 10 79627.003 NM_024576.3 CQ725357.1
  • GENBANK_PATENT 1 965 7169.015.1-D_at ⁇ 0.59148 0.59147642 7.035949 2E ⁇ 10 7169.015.
  • NM_014211.1 CD696885.1 EST 1 973 5311.003.1-T_at ⁇ 0.59073 0.59073163 7.022336 2E ⁇ 10 5311.003.
  • NM_000297.2 DA153606.1
  • NM_002971.2 BP359118.1 EST 1 975 3861.008.1-B_at ⁇ 0.59048 0.59048159 7.017772 2E ⁇ 10 3861.008.
  • NM_000526.3 BE184532.1 EST 1 976 7018.013.1-B_at ⁇ 0.59035 0.59035214 7.01541 2E ⁇ 10 7018.013.
  • NM_004684.2 DA763956.1 EST 1 978 7170.027.1-C_at 0.590216 0.59021624 7.012932 2E ⁇ 10 7170.027.
  • NM_153649.2 BQ959117.1 EST 1 979 8404.023.1-C_at ⁇ 0.59009 0.59009089 7.010646 2E ⁇ 10 8404.023.
  • NM_001034.1 BG261296.1 EST 1 985 1410.001.1-T_at ⁇ 0.5894 0.58939515 6.997977 2E ⁇ 10 1410.001.
  • NM_001885.1 W40377.1 EST 1 986 4781.015.2-B_at ⁇ 0.58938 0.5893752 6.997614 2E ⁇ 10 4781.015.
  • NM_005596.1 DN995118.1 EST 1 987 72.002.1-T_at ⁇ 0.58937 0.58936787 6.99748 2E ⁇ 10 72.002.1 NM_001615.3 BP372072.1 EST 2 988 4833.004.1-D_at 0.589279 0.58927851 6.995855 2E ⁇ 10 4833.004.
  • NM_005009.2 BG478602.1 EST 8 989 57447.024.1-D_at ⁇ 0.58924 0.58924443 6.995235 2E ⁇ 10 57447.024 NM_201535.1 DA566498.1 EST 1 990 2982.013.2-T_at ⁇ 0.5892 0.58920321 6.994486 2E ⁇ 10 2982.013.
  • NM_000856.2 CF594362.1 EST 1 991 79971.012.1-T_at ⁇ 0.58907 0.5890694 6.992053 2E ⁇ 10 79971.012 NM_001002292.
  • BG702604.1 EST 1 992 8404.028.3-C_at ⁇ 0.589 0.58899948 6.990782 2E ⁇ 10 8404.028.
  • NM_004684.2 CQ727530.1
  • GENBANK_PATENT 1 993 4638.011.1-E_at ⁇ 0.58897 0.58897325 6.990305 2E ⁇ 10 4638.011.
  • NM_053025.2 DB267860.1 EST 1 994 7169.004.1-C_at ⁇ 0.58895 0.58894617 6.989813 2E ⁇ 10 7169.004.
  • NM_213674.1 BG027526.1 EST 1 995 4288.004.1-F_at 0.588788 0.58878813 6.986942 2E ⁇ 10 4288.004.
  • NM_212482.1 CQ875357.1 GENBANK_PATENT 281 1000 259266.003.1-C 0.588552 0.58855227 6.98266 2E ⁇ 10 259266.00 NM_018136.2 CB217235.1 EST 1 1001 9055.020.1-T_at 0.588545 0.58854487 6.982525 2E ⁇ 10 9055.020.
  • NM_003981.2 BP363287.1 EST 1 1002 7091.016.1-T_at ⁇ 0.58837 0.58836788 6.979313 2E ⁇ 10 7091.016.
  • NM_007005.3 DA323941.1 EST 1 1003 59.023.1-T_at ⁇ 0.5882 0.58819673 6.976209 2E ⁇ 10 59.023.1 NM_001613.1 DB248573.1 EST 1 1004 57162.010.1-B_at ⁇ 0.58814 0.58813698 6.975125 2E ⁇ 10 57162.010 NM_020651.2 DB241492.1 EST 1 1005 4781.002.2-D_at ⁇ 0.58809 0.58808634 6.974207 2E ⁇ 10 4781.002.
  • NM_005928.1 AA021047.1 EST 1 1008 59.034.1-T_at ⁇ 0.58783 0.58782732 6.969513 2E ⁇ 10 59.034.1 — — — — 1009 8404.004.2-D_at ⁇ 0.58782 0.58782345 6.969443 2E ⁇ 10 8404.004.
  • NM_004684.2 DA589023.1 EST 1 1010 9413.001.2-T_at ⁇ 0.58777 0.5877726 6.968522 2E ⁇ 10 9413.001.
  • NM_004816.2 DA824091.1 EST 1 1011 2.005.1-F_at ⁇ 0.58772 0.58771984 6.967566 2E ⁇ 10 2.005.1 NM_000014.4 BI493707.1
  • NM_000424.2 R47851.1 EST 1 1014 7170.027.1-B_at 0.587642 0.58764175 6.966152 2E ⁇ 10 7170.027.
  • NM_153649.2 BQ959117.1
  • NM_003012.3 AX565729.1 GENBANK_PATENT 3 1020 6241.013.1-F_at 0.587043 0.58704329 6.955324 3E ⁇ 10 6241.013.
  • NM_001034.1 BG261296.1 EST 1 1021 2335.032.1-T_at 0.58699 0.58699048 6.95437 3E ⁇ 10 2335.032.
  • NM_001885.1 BI561839.1 EST 1 1027 7170.040.1-E_at 0.586568 0.58656826 6.946742 3E ⁇ 10 7170.040.
  • NM_153649.2 BG283654.1 EST 1 1028 6289.002.2-F_at ⁇ 0.5864 0.58639668 6.943645 3E ⁇ 10 6289.002.
  • NM_030754.2 AA345111.1 EST 1 1029 7373.003.4-C_at ⁇ 0.58637 0.58636622 6.943095 3E ⁇ 10 7373.003.
  • NM_153649.2 BF967161.1 EST 4 1031 128553.003.1-B ⁇ 0.586 0.58599544 6.936408 3E ⁇ 10 128553.00 NM_173485.2 BP394387.1
  • NM_004684.2 CD001002.1 EST 1 1036 59.029.1-T_at ⁇ 0.58564 0.58563959 6.929996 3E ⁇ 10 59.029.1 NM_001613.1 AL540709.3 EST 1 1037 29089.001.1-T_at 0.585601 0.58560082 6.929298 3E ⁇ 10 29089.001 NM_014176.1 CA495294.1 EST 2 1038 358.012.1-T_at ⁇ 0.5856 0.58559702 6.929229 3E ⁇ 10 358.012.1 NM_198098.1 AX597685.1 GENBANK_PATENT 1 1039 9134.001.1-B_at 0.585561 0.58556099 6.92858 3E ⁇ 10 9134.001.
  • NM_212482.1 AL551632.3 EST 2 1041 1410.010.1-T_at ⁇ 0.58543 0.58542981 6.926219 3E ⁇ 10 1410.010.
  • NM_001885.1 AJ710474.1 EST 2 1042 2327.003.4-F_at ⁇ 0.58542 0.58541593 6.925969 3E ⁇ 10 2327.003.
  • NM_001885.1 BF670917.1 EST 1 1048 80034.004.1-T_at ⁇ 0.58483 0.58482793 6.915393 3E ⁇ 10 80034.004 NM_024969.2 DA786544.1 EST 1 1049 1410.008.1-T_at ⁇ 0.58477 0.58476949 6.914343 3E ⁇ 10 1410.008.
  • NM_001885.1 R68496.1 EST 1 1050 57447.051.2-D_at ⁇ 0.5847 0.58469568 6.913017 3E ⁇ 10 57447.051 NM_201535.1 BX460053.2 EST 1 1051 7170.016.3-B_at 0.58466 0.58466041 6.912384 3E ⁇ 10 7170.016.
  • NM_153649.2 BF575596.1
  • EST 1 1052 4240.001.1-C_at ⁇ 0.58464 0.58463983 6.912014 3E ⁇ 10 4240.001.
  • NM_005928.1 BF525404.1
  • EST 1 1053 6288.001.1-T_at ⁇ 0.58463 0.58462773 6.911797 3E ⁇ 10 6288.001.
  • NM_030754.2 CR744712.1 EST 1 1057 6876.011.1-F_at ⁇ 0.58434 0.58433766 6.906588 3E ⁇ 10 6876.011.
  • NM_000204.1 CQ718881.1 GENBANK_PATENT 1 1070 53829.001.2-T_at ⁇ 0.58296 0.58295977 6.881904 4E ⁇ 10 53829.001 NM_023914.2 NM_176894.1 REFSEQ 12 1071 2115.001.2-B_at ⁇ 0.58274 0.58274226 6.878015 4E ⁇ 10 2115.001.
  • NM_005656.2 DA460061.1 EST 1 1083 4781.014.2-B_at ⁇ 0.5816 0.58160201 6.857667 4E ⁇ 10 4781.014.
  • NM_005596.1 DN918235.1 EST 1 1084 2335.016.1-E_at 0.581544 0.58154398 6.856633 4E ⁇ 10 2335.016.
  • GENBANK_PATENT 281 1085 11065.003.1-T_at 0.581391 0.58139079 6.853905
  • GENBANK_PATENT 5 1086 3872.006.1-T_at ⁇ 0.58132 0.58131729 6.852596
  • NM_000422.1 BM017443.1 EST 1 1087 3084.005.1-F_at ⁇ 0.58129 0.58128817 6.852078 4E ⁇ 10 3084.005.
  • NM_004684.2 DA589023.1 EST 1 1091 54829.001.1-F_at 0.580792 0.58079186 6.843247 4E ⁇ 10 54829.001 NM_017680.3 AK027359.1 mRNA 4 1092 8404.001.1-T_at ⁇ 0.58046 0.58046456 6.83743 4E ⁇ 10 8404.001. NM_004684.2 DA132781.1 EST 1 1093 9055.011.1-E_at 0.580443 0.58044278 6.837043 4E ⁇ 10 9055.011.
  • NM_003981.2 CX868839.1 EST 1 1094 6289.003.2-F_at ⁇ 0.58043 0.58043238 6.836859 4E ⁇ 10 6289.003.
  • NM_030754.2 R83510.1 EST 1 1095 22974.007.1-T_at 0.580276 0.5802757 6.834076 4E ⁇ 10 22974.007 NM_012112.4 AF287265.1 mRNA 213 1096 59.023.2-T_at ⁇ 0.58018 0.58017715 6.832326 4E ⁇ 10 59.023.2 NM_001613.1 DB248573.1 EST 1 1097 7169.015.1-T_at ⁇ 0.58013 0.58013361 6.831554 4E ⁇ 10 7169.015.
  • NM_153649.2 BE208737.1 EST 1 1106 7018.025.1-B_at ⁇ 0.57934 0.57934031 6.817488 5E ⁇ 10 7018.025.
  • NM_005596.1 AK131233.1 mRNA 2 1126 7373.003.1-F_at ⁇ 0.57736 0.57736415 6.782575 6E ⁇ 10 7373.003.
  • NM_021110.1 CQ716670.1 GENBANK_PATENT 1 1127 8404.009.1-D_at ⁇ 0.57736 0.57735822 6.78247 6E ⁇ 10 8404.009.
  • NM_005656.2 CQ976407.1 GENBANK_PATENT 1 1138 4240.009.1-D_at ⁇ 0.57692 0.57692271 6.7748 6E ⁇ 10 4240.009.
  • NM_005928.1 BG829936.1 EST 2 1139 7153.002.4-B_at 0.576735 0.57673523 6.771501 6E ⁇ 10 7153.002.
  • NM_001067.2 CQ735949.1
  • DA878291.1 EST 1 1148 152015.005.2-F ⁇ 0.5759 0.57589713 6.756772 6E ⁇ 10 152015.00 NM_001012337. CQ732372.1 GENBANK_PATENT 1 1149 4288.005.1-D_at 0.575849 0.57584855 6.75592 6E ⁇ 10 4288.005. NM_002417.2 BM455229.1 EST 1 1150 8404.002.1-T_at ⁇ 0.57584 0.57584028 6.755774 6E ⁇ 10 8404.002. NM_004684.2 BP383384.1 EST 1 1151 6441.004.1-E_at ⁇ 0.57578 0.5757767 6.754659 6E ⁇ 10 6441.004.
  • NM_003019.4 BG542824.1 EST 1 1152 6122.046.1-B_at ⁇ 0.57577 0.57577128 6.754563 6E ⁇ 10 6122.046.
  • NM_000967.3 BM019962.1 EST 1 1153 115908.002.1-T 0.575641 0.57564097 6.752277 6E ⁇ 10 115908.00 NM_138455.2 AF395488.1 mRNA 1 1154 9481.001.1-F_at ⁇ 0.57564 0.5756408 6.752274 6E ⁇ 10 9481.001.
  • NM_004684.2 DA342341.1 EST 1 1156 1410.007.1-D_at ⁇ 0.57559 0.57559279 6.751432 6E ⁇ 10 1410.007.
  • NM_004684.2 CD357736.1 EST 1 1158 57447.039.1-T_at ⁇ 0.57552 0.57551972 6.75015 6E ⁇ 10 57447.039 NM_201535.1 DA356658.1 EST 1 1159 4147.004.1-E_at ⁇ 0.57546 0.57545554 6.749025 7E ⁇ 10 4147.004.
  • NM_212482.1 CQ731573.1 GENBANK_PATENT 1 1161 891.007.1-T_at 0.575369 0.57536931 6.747513 7E ⁇ 10 891.007.1 NM_031966.2 BT020128.1 mRNA 1 1162 2335.002.1-T_at 0.575308 0.57530785 6.746436 7E ⁇ 10 2335.002.
  • NM_004684.2 CD001002.1 EST 1 1164 57451.004.1-B_at ⁇ 0.57522 0.57521923 6.744883 7E ⁇ 10 57451.004 XM_931456.1 AK056053.1 mRNA 5 1165 8404.001.1-F_at ⁇ 0.57518 0.57517525 6.744112 7E ⁇ 10 8404.001. NM_004684.2 DA132781.1 EST 1 1166 8626.006.2-B_at ⁇ 0.57508 0.57507892 6.742424 7E ⁇ 10 8626.006.
  • NM_002417.2 BE840921.1 EST 1 1198 244.011.1-T_at ⁇ 0.5724 0.57240479 6.69574 8E ⁇ 10 244.011.1 NM_001630.1 BX399166.2 EST 1 1199 94274.003.1-B_at ⁇ 0.57238 0.57238283 6.695358 8E ⁇ 10 94274.003 NM_033256.1 AB056509.1 mRNA 1 1200 3178.003.1-E_at ⁇ 0.57235 0.5723545 6.694865 8E ⁇ 10 3178.003. NM_031157.2 DA761057.1 EST 1 1201 7153.002.4-T_at 0.572294 0.57229362 6.693806 8E ⁇ 10 7153.002.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 1202 9055.012.1-D_at 0.57223 0.57222967 6.692694 8E ⁇ 10 9055.012.
  • NM_003981.2 BE298728.1 EST 1 1203 9232.001.1-E_at 0.572158 0.57215824 6.691452 8E ⁇ 10 9232.001.
  • NM_002417.2 BP232141.1 EST 1 1227 7170.014.1-C_at 0.570269 0.57026859 6.658675 1E ⁇ 09 7170.014.
  • NM_153649.2 DA690776.1 EST 1 1228 7170.007.1-D_at 0.570241 0.57024107 6.658199 1E ⁇ 09 7170.007.
  • NM_002417.2 BE840921.1 EST 1 1235 301.008.1-T_at ⁇ 0.5693 0.56929536 6.641856 1E ⁇ 09 301.008.1 NM_000700.1 CD688703.1
  • NM_006206.3 BP321319.1 EST 1 1237 4781.001.1-F_at ⁇ 0.56917 0.56917015 6.639695 1E ⁇ 09 4781.001.
  • NM_005596.1 BF541662.1 EST 1 1238 4281.016.1-E_at ⁇ 0.56916 0.56915511 6.639435 1E ⁇ 09 4281.016.
  • NM_002758.2 BP220368.1 EST 1 1255 9055.014.1-D_at 0.56752 0.56752001 6.61128 1E ⁇ 09 9055.014.
  • NM_003981.2 BE300335.1 EST 1 1256 5156.009.1-F_at ⁇ 0.56751 0.56750707 6.611058 1E ⁇ 09 5156.009.
  • NM_033290.1 AY540016.1 mRNA 1 1271 57447.020.1-T_at ⁇ 0.56666 0.56665556 6.596441 1E ⁇ 09 57447.020 NM_201535.1 BX461883.2 EST 5 1272 7170.035.2-D_at 0.566638 0.56663777 6.596136 1E ⁇ 09 7170.035.
  • NM_153649.2 BF575164.1 EST 1 1273 10124.005.1-T_at ⁇ 0.56646 0.56645955 6.593081 1E ⁇ 09 10124.005 NM_001037164.
  • NM_014211.1 CD696885.1 EST 1 1279 55713.004.1-T_at ⁇ 0.56607 0.56607498 6.586493 1E ⁇ 09 55713.004 NM_018102.3 AL833936.1 mRNA 1 1280 2335.026.3-F_at 0.565913 0.56591326 6.583725 1E ⁇ 09 2335.026.
  • NM_212482.1 BX641150.1 mRNA 43 1281 7168.010.1-C_at ⁇ 0.56585 0.56585375 6.582706 1E ⁇ 09 7168.010.
  • CD556048.1 EST 1 1282 1959.002.1-T_at ⁇ 0.56583 0.56583226 6.582339 1E ⁇ 09 1958.002.
  • NM_002533.2 CQ731324.1 GENBANK_PATENT 1 1290 57447.039.1-C_at ⁇ 0.5653 0.56530385 6.573303 1E ⁇ 09 57447.039 NM_201535.1 DA356658.1 EST 1 1291 57561.001.1-T_at ⁇ 0.56529 0.56529076 6.573079 1E ⁇ 09 57561.001 NM_020801.1 BQ428339.1 EST 1 1292 57447.002.1-D_at ⁇ 0.56527 0.56526525 6.572643 1E ⁇ 09 57447.002 NM_201535.1 BF526188.1 EST 1 1293 4094.001.1-B_at ⁇ 0.56526 0.56525669 6.572497 1E ⁇ 09 4094.001.
  • NM_002533.2 BU170621.1 EST 1 1297 79971.010.2-T_at ⁇ 0.56505 0.56505357 6.569027 1E ⁇ 09 79971.010 NM_001002292.
  • CB268343.1 EST 1 1298 29127.009.1-T_at 0.564971 0.56497093 6.567616 1E ⁇ 09 29127.009 NM_013277.2
  • BX421176.2 EST 1 1299 2770.004.1-T_at ⁇ 0.56473 0.56473004 6.563504 2E ⁇ 09 2770.004.
  • NM_002069.4 DA801873.1 EST 1 1300 59.015.2-F_at ⁇ 0.56468 0.56468244 6.562692 2E ⁇ 09 59.015.2
  • NM_001613.1 BP372009.1 EST 1 1301 2335.032.1-B_at 0.564674 0.56467386 6.562545 2E ⁇ 09 2335.032.
  • NM_212482.1 DA647475.1 EST 1 1302 1410.006.1-B_at ⁇ 0.56446 0.56446046 6.558905 2E ⁇ 09 1410.006.
  • NM_002644.2 AX012182.1 GENBANK_PATENT 1 1321 301.003.1-T_at ⁇ 0.56291 0.56291408 6.532585 2E ⁇ 09 301.003.1 NM_000700.1 CB124198.1 EST 1 1322 4240.007.1-F_at ⁇ 0.5629 0.56290348 6.532405 2E ⁇ 09 4240.007.
  • NM_005928.1 CN485231.1 EST 1 1323 4240.007.1-B_at ⁇ 0.56283 0.56283211 6.531193 2E ⁇ 09 4240.007.
  • NM_001018020 AA096317.1 EST 1 1330 90293.004.2-T_at ⁇ 0.56231 0.56231454 6.522407 2E ⁇ 09 90293.004 NM_033495.2 AL591986.1 mRNA 38 1331 1410.006.1-D_at ⁇ 0.56207 0.56206646 6.518201 2E ⁇ 09 1410.006.
  • NM_001885.1 BF670917.1 EST 1 1332 7113.010.1-E_at ⁇ 0.56205 0.56205065 6.517933 2E ⁇ 09 7113.010.
  • DA711278.1 EST 1 1335 4240.005.1-T_at ⁇ 0.56194 0.5619438 6.516122 2E ⁇ 09 4240.005.
  • NM_004684.2 CQ727530.1
  • GENBANK_PATENT 1 1349 11130.004.1-T_at 0.561027 0.56102703 6.500602 2E ⁇ 09 11130.004 NM_001005414.
  • BQ065119.1 EST 1 1350 2568.002.2-B_at ⁇ 0.56101 0.56100825 6.500285 2E ⁇ 09 2568.002.
  • NM_213674.1 BQ923578.1 EST 67 1361 7170.026.1-C_at 0.560224 0.5602241 6.487039 2E ⁇ 09 7170.026.
  • NM_153649.2 BQ933569.1
  • EST 1 1362 667.010.1-B_at ⁇ 0.56012 0.56011837 6.485255 2E ⁇ 09 667.010.1 NM_183380.1
  • DA361412.1 EST 1 1363 4781.010.1-F_at ⁇ 0.56006 0.56006097 6.484286 2E ⁇ 09 4781.010.
  • NM_000856.2 BX649180.1 mRNA 10 1373 152015.005.1-F ⁇ 0.55929 0.55929021 6.471297 2E ⁇ 09 152015.00 NM_001012337.
  • CQ732372.1 GENBANK_PATENT 1 1374 3914.001.1-C_at ⁇ 0.5592 0.55919902 6.469761 2E ⁇ 09 3914.001.
  • NM_000228.2 CQ921791.1 GENBANK_PATENT 2 1375 7168.012.2-B_at ⁇ 0.55912 0.55911961 6.468425 2E ⁇ 09 7168.012.
  • NM_001018020 CQ732372.1 GENBANK_PATENT 1 1374 3914.001.1-C_at ⁇ 0.5592 0.55919902 6.469761 2E ⁇ 09 3914.001.
  • NM_000228.2 CQ921791.1 GENBANK_PATENT 2 1375 7168.012.2-B_at ⁇
  • NM_002417.2 BM455229.1 EST 1 1382 2938.007.1-T_at ⁇ 0.55888 0.55887858 6.464369 2E ⁇ 09 2938.007.
  • NM_145740.2 AX477713.1 GENBANK_PATENT 1 1383 29127.020.1-T_at 0.558848 0.55884819 6.463858 2E ⁇ 09 29127.020 NM_013277.2 DB089267.1
  • GENBANK_PATENT 1 1385 9232.001.1-T_at 0.558605 0.55860527 6.459774 2E ⁇ 09 9232.001.
  • NM_004219.2 CN285866.1 EST 1 1386 55214.004.1-T_at ⁇ 0.55803 0.55802814 6.450079 3E ⁇ 09 55214.004 NM_018192.2 DA953365.1 EST 1 1387 79971.002.1-B_at ⁇ 0.55798 0.5579779 6.449236 3E ⁇ 09 79971.002 NM_001002292.
  • CQ720425.1 GENBANK_PATENT 1 1388 3977.002.1-T_at ⁇ 0.55793 0.55793279 6.448479 3E ⁇ 09 3977.002.
  • NM_002310.3 DR005799.1 EST 1 1389 7170.028.1-F_at 0.557857 0.5578569 6.447206 3E ⁇ 09 7170.028.
  • NM_153649.2 BQ220396.1 EST 2 1390 1410.009.1-E_at ⁇ 0.55785 0.55784993 6.447089 3E ⁇ 09 1410.009.
  • NM_001885.1 BQ437433.1 EST 2 1391 4781.004.1-T_at ⁇ 0.55762 0.55762387 6.443297 3E ⁇ 09 4781.004.
  • NM_005656.2 CQ976404.1 GENBANK_PATENT 2 1409 390.003.1-T_at ⁇ 0.55648 0.55648155 6.424167 3E ⁇ 09 390.003.1 NM_005168.3 DA532407.1 EST 1 1410 6304.002.2-T_at ⁇ 0.55641 0.55641323 6.423025 3E ⁇ 09 6304.002. NM_002971.2 BC001744.1 mRNA 33 1411 6304.009.2-T_at ⁇ 0.55633 0.55633335 6.42169 3E ⁇ 09 6304.009.
  • NM_002971.2 DA497369.1 EST 1 1412 3872.017.1-T_at ⁇ 0.55631 0.55631309 6.421351 3E ⁇ 09 3872.017.
  • NM_000422.1 BX378477.2 EST 1 1413 2335.013.1-D_at 0.556298 0.55629818 6.421102 3E ⁇ 09 2335.013.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 1426 4240.001.1-T_at ⁇ 0.55574 0.55573744 6.411735 3E ⁇ 09 4240.001.
  • NM_005928.1 BF525404.1 EST 1 1427 58499.005.1-T_at ⁇ 0.55571 0.55571242 6.411317 3E ⁇ 09 58499.005 NM_021224.3 BI461756.1 EST 1 1428 7168.026.1-C_at ⁇ 0.55559 0.55558982 6.409271 3E ⁇ 09 7168.026.
  • NM_001018020 GENBANK_PATENT 114 1426 4240.001.1-T_at ⁇ 0.55574 0.55573744 6.411735 3E ⁇ 09 4240.001.
  • NM_005928.1 BF525404.1
  • EST 1 1427 58499.005.1-T_at ⁇ 0.55571 0.55571242 6.411317 3E ⁇ 09
  • NM_004454.1 BE408130.1 EST 1 1437 1959.001.2-T_at ⁇ 0.55498 0.55498357 6.399162 3E ⁇ 09 1959.001.
  • NM_000399.2 DB086600.1 EST 1 1438 9824.006.1-T_at 0.55476 0.55475962 6.395432 3E ⁇ 09 9824.006.
  • NM_004454.1 DB094869.1 EST 1 1449 6304.011.2-T_at ⁇ 0.55412 0.55411832 6.38476 3E ⁇ 09 6304.011.
  • NM_000967.3 BF315041.1 EST 1 1460 4781.014.2-T_at ⁇ 0.55315 0.55315167 6.368705 4E ⁇ 09 4781.014.
  • NM_005596.1 DN918235.1
  • NM_001018020 BP257563.1 EST 1 1462 4147.003.1-F_at ⁇ 0.55281 0.55280885 6.36302 4E ⁇ 09 4147.003.
  • NM_002380.3 AY358895.1 mRNA 81 1463 57451.001.3-B_at ⁇ 0.55273 0.55273245 6.361754 4E ⁇ 09 57451.001 XM_931456.1 CS188752.1 GENBANK_PATENT 1 1464 9055.018.1-T_at 0.552521 0.55252074 6.358246 4E ⁇ 09 9055.018.
  • NM_003981.2 DA033856.1 EST 1 1465 4931.013.1-T_at 0.552443 0.552443 6.356958 4E ⁇ 09 4931.013.
  • NM_014211.1 AK055205.1 mRNA 11 1468 4435.001.1-T_at ⁇ 0.5524 0.55240125 6.356267 4E ⁇ 09 4435.001.
  • NM_001460.2 CD684429.1 EST 1 1524 3945.014.1-B_at ⁇ 0.54812 0.54812393 6.285794 5E ⁇ 09 3945.014.
  • NM_002300.3 BG402389.1
  • EST 1 1525 151438.003.1-C ⁇ 0.54801 0.54801484 6.284006 5E ⁇ 09 151438.00 AK055877.1 DB124570.1
  • NM_005656.2 DA627080.1 EST 1 1527 441417.001.1-B ⁇ 0.54784 0.54783722 6.281095 5E ⁇ 09 441417.00 XM_497039.2 XM_933326.1 REFSEQ 3 1528 2982.012.1-F_at ⁇ 0.54781 0.54781217 6.280685 6E ⁇ 09 2982.012.
  • NM_000856.2 BC012627.1 mRNA 2 1529 7168.005.3-E_at ⁇ 0.54767 0.54766942 6.278347 6E ⁇ 09 7168.005.
  • NM_001018020 EST 1 1527 441417.001.1-B ⁇ 0.54784 0.54783722 6.281095 5E ⁇ 09 441417.00 XM_497039.2 XM_933326.1 REFSEQ 3 1528 2982.012.1-F_at ⁇ 0.54781 0.54781217 6.280685 6E ⁇ 09 2982.012.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 1544 2568.005.2-D_at ⁇ 0.5465 0.5464996 6.259217 6E ⁇ 09 2568.005.
  • NM_014211.1 AK055205.1 mRNA 11 1545 2335.039.1-F_at 0.546413 0.5464132 6.257806 6E ⁇ 09 2335.039.
  • NM_153649.2 DA893534.1 EST 1 1550 667.014.1-T_at ⁇ 0.54573 0.54572906 6.246645 6E ⁇ 09 667.014.1 NM_183380.1 CQ851391.1 GENBANK_PATENT 1 1551 4781.009.2-D_at ⁇ 0.54569 0.54568951 6.246 6E ⁇ 09 4781.009. NM_005596.1 CQ732556.1 GENBANK_PATENT 1 1552 7169.001.1-D_at ⁇ 0.54565 0.54565203 6.24539 6E ⁇ 09 7169.001.
  • AK129882.1 mRNA 2 1556 10010.004.1-E_at ⁇ 0.54541 0.54540884 6.241427 7E ⁇ 09 10010.004 NM_004180.2 BM750784.1 EST 1 1557 54443.009.1-D_at 0.545394 0.54539371 6.241181 7E ⁇ 09 54443.009 NM_018685.2 DA242046.1 EST 1 1558 7039.002.1-D_at ⁇ 0.54538 0.54537813 6.240927 7E ⁇ 09 7039.002.
  • NM_003981.2 BE300335.1 EST 1 1563 79971.013.1-T_at ⁇ 0.54495 0.54494911 6.233942 7E ⁇ 09 79971.013 NM_001002292.
  • DA878291.1 EST 1 1564 11065.003.2-T_at 0.544945 0.5449453 6.23388 7E ⁇ 09 11065.003 NM_181802.1 CS138819.1
  • GENBANK_PATENT 5 1565 7113.009.1-E_at ⁇ 0.54493 0.54493426 6.233701 7E ⁇ 09 7113.009.
  • NM_005656.2 DA873416.1 EST 1 1566 51203.002.2-T_at 0.544867 0.54486653 6.232599 7E ⁇ 09 51203.002 NM_016359.2 AL561514.3 EST 1 1567 7170.006.1-B_at 0.54486 0.54486029 6.232497 7E ⁇ 09 7170.006.
  • NM_153649.2 DB003864.1 EST 1 1568 80034.002.1-T_at ⁇ 0.54484 0.54484345 6.232223 7E ⁇ 09 80034.002 NM_024969.2 DA769284.1 EST 1 1569 1345.012.1-D_at 0.544806 0.54480624 6.231618 7E ⁇ 09 1345.012.
  • NM_130439.3 CS031066.1 GENBANK_PATENT 3 1573 3709.004.1-E_at ⁇ 0.54444 0.54444277 6.225708 7E ⁇ 09 3709.004.
  • NM_002223.1 BP364657.1 EST 1 1574 4781.017.2-T_at ⁇ 0.5444 0.54440035 6.225019 7E ⁇ 09 4781.017.
  • AK092573.1 mRNA 5 1581 55732.003.1-T_at 0.543852 0.54385205 6.216114 7E ⁇ 09 55732.003 NM_018186.2 DA733233.1 EST 2 1582 23266.001.1-T_at ⁇ 0.54381 0.54380864 6.21541 7E ⁇ 09 23266.001 NM_012302.2 AK123422.1 mRNA 2 1583 4288.006.2-E_at 0.543777 0.54377742 6.214903 7E ⁇ 09 4288.006. NM_002417.2 BP363635.1 EST 1 1584 4781.013.2-D_at ⁇ 0.54375 0.5437474747 6.214417 7E ⁇ 09 4781.013.
  • NM_153649.2 BM011010.1 EST 1 1587 51201.007.1-T_at ⁇ 0.54346 0.5434567 6.2097 8E ⁇ 09 51201.007 NM_016353.2 BF541714.1 EST 1 1588 7169.002.1-F_at ⁇ 0.54328 0.54327991 6.206834 8E ⁇ 09 7169.002.
  • NM_005596.1 DN995118.1 EST 1 1591 9055.012.1-T_at 0.543077 0.54307679 6.203543 8E ⁇ 09 9055.012.
  • NM_003981.2 BE298728.1 EST 1 1592 2893.004.1-T_at ⁇ 0.5429 0.54289557 6.200607 8E ⁇ 09 2893.004.
  • NM_000829.1 DA066848.1 EST 1 1593 91653.015.1-T_at ⁇ 0.54284 0.54283984 6.199705 8E ⁇ 09 91653.015 NM_033254.2 R75666.1 EST 1 1594 10010.001.1-T_at ⁇ 0.54281 0.54280637 6.199163 8E ⁇ 09 10010.001 NM_004180.2 DA670701.1 EST 6 1595 1410.003.2-T_at ⁇ 0.54281 0.54280581 6.199154 8E ⁇ 09 1410.003.
  • NM_001885.1 AX899079.1 GENBANK_PATENT 1 1596 6595.013.1-B_at ⁇ 0.54268 0.54268082 6.19713 8E ⁇ 09 6595.013.
  • NM_003070.3 DA825858.1 EST 1 1597 4601.009.1-T_at ⁇ 0.54264 0.54264498 6.19655 8E ⁇ 09 4601.009.
  • NM_020127.1 BP315579.1 EST 1 1603 4931.004.1-T_at 0.54224 0.54223963 6.189993 8E ⁇ 09 4931.004.
  • NM_002533.2 BM693264.1 EST 1 1604 7113.005.1-E_at ⁇ 0.54224 0.5422385 6.189974 8E ⁇ 09 7113.005.
  • NM_001067.2 CQ735949.1 GENBANK_PATENT 114 1613 54443.001.1-F_at 0.541435 0.54143463 6.176988 9E ⁇ 09 54443.001 NM_018685.2 BC070066.1 mRNA 10 1614 142.012.1-F_at 0.541335 0.54133459 6.175374 9E ⁇ 09 142.012.1 NM_001618.2
  • CQ717842.1 GENBANK_PATENT 1 1633 57447.004.1-B_at ⁇ 0.54026 0.54025744 6.158014 1E ⁇ 08 57447.004
  • NM_201535.1 CD515320.1
  • NM_000856.2 DB179470.1 EST 1 1635 4288.005.1-T_at 0.539862 0.53986198 6.151651 1E ⁇ 08 4288.005.
  • NM_002417.2 BM455229.1 EST 1 1636 10957.018.1-F_at ⁇ 0.53982 0.53982225 6.151012 1E ⁇ 08 10957.018 NM_006813.1 AI547283.1 EST 1 1637 2568.006.2-B_at ⁇ 0.53981 0.53980996 6.150815 1E ⁇ 08 2568.006.
  • NM_014211.1 CD385249.1 EST 1 1638 10051.015.2-F_at 0.539796 0.53979645 6.150597 1E ⁇ 08 10051.015 NM_001002799.
  • prediction rules were constructed using the top 50, top 100, top 150 and top 200 polynucleotide probe sets of Table 4 (with identifiers no 1 to no 50, no 1 to no 100, no 1 to no 150 and no 1 to no 200).
  • the estimated prediction accuracies by leave-one-out crossvalidation were as follows:
  • Table 5 contains the average profiles of the preferred 1,228 signature polynucleotide probe sets with p ⁇ 10e-9 measured on the 24 benign and 70 malignant tissues of the training set. Thus, the preferred set of probes to be used for predicting the malignant status of a tissue of a future patient is reported here.
  • the inventors have developed an optimal prediction rule based on the methodology reported previously.
  • the preferred p-value threshold for defining signature genes was p ⁇ 10e-9.
  • the inventors When using leave-one-out cross-validation to estimate the prediction accuracy of the prediction rule with this particular threshold, the inventors accurately classified all the samples as shown in FIG. 4 . This corresponds to a sensitivity of 100% and a specificity of 100%.
  • Table 5 contains the average profiles of the preferred 1228 signature probe sets with p ⁇ 10e-9 measured on the 20 benign and 74 malignant tissues of the training set. The probes with positive correlation are those which have increased expression in malignant tissues, those with negative correlation have increased expression in the benign tissues.
  • a validation set was carried-out that included overall 71 samples. Of these, 21 and 50 were benign lesions and breast cancer respectively. Using this dataset, the inventors assessed the performances of the 1228 signature probes to predict for breast cancer as opposed to benign lesions. Overall 68 out of 71 samples were accurately classified (96%). Sensitivity and specificity of the tests were 96% (95% CI: 90.5-100) and 95% (95% CI: 86.1-100). The correlation of each specimen with the malignant and benign profile is reported in FIG. 6 . Of the three misclassified specimen, one corresponded to a benign tumor (inflammatory granulomatosis) classified as malignant, and two were malignant tumors classified as benign by molecular predictor.
  • a benign tumor inflammatory granulomatosis
  • the inventors then evaluated the add-value of molecular predictor to cytological exam, and to a model that included classification of American College of Radiology (ACR) and age. Cytological exam failed to provide a definitive diagnosis in 5 out of 71 patients. Four out of these 5 patients were accurately classified by the molecular predictor. The proportion of explained variation (PEV) by Clinical model (age and ACR) was 75%+ ⁇ 8%, while the PEV by molecular predictor was 81% (+/ ⁇ 10%). When clinical model and molecular predictor were combined, the PEV was 87% (+/ ⁇ 7%), suggesting that molecular predictor presented an add-value of 12% (+/ ⁇ 7%) to the clinical model.
  • PEV proportion of explained variation
  • the use of the 1228, or 1640, polynucleotide probe sets according to the invention allows, without ambiguity, and misclassification, to determine if a breast tumor is benign or malignant.
  • the inventors have reported the exonic portrait of breast malignancy.
  • the analysis of differential exonic events between malignant and benign lesions provides a complete picture of genomic anomalies associated with breast malignancy.
  • the present study reveals a high level of genomic dysregulation between malignant and benign breast lesions.
  • the inventors found out that 56652 out of 703680 evidenced probes (8%) were different among the two conditions.
  • the analysis focused on gene expression level (geo mean of probe sets) 3733 out of 20649 genes (7%) were differentially expressed between malignant and benign lesions. Analysis of gene expression levels revealed overexpression of candidate genes for further investigations.
  • PTTG1 Pituitary Tumor Transforming 1
  • NET1 Neuroepithelial cell transforming gene 1
  • RhoA RhoA
  • 2675 exon-probes that did not belong to genes identified as differentially expressed, actually presented a significantly higher intensity in breast cancer.
  • a high proportion of these 2675 exon-probes presented a significantly increased splice index in breast cancer as compared to benign tumors.
  • These exon-probes were considered to present a higher difference of intensity between cancer and benign lesions, as compared to the one of their relative genes.
  • Several of these exons are located within genes linked to cancer biology (casein kinase 1, delta (Gao Z H, Seeling J M, Hill V, Yochum A, Virshup D M. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
  • retinoblastoma binding protein 9 (Woitach J T, Zhang M, Niu C H, Thorgeirsson S S. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 August; 19(4):371-4) and ERB2 interacting protein (Jaulin-Bastard F, Arsanto J P, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni M J, Birnbaum D, Borg J P. Interaction between Erbin and a Catenin related protein in epithelial cells.
  • Fine needle aspiration cytology versus percutaneous biopsy of nonpalpable breast lesions. Eur J Radiol. 2002 April; 42(1):10-6). Fine needle aspiration is a safer and easier approach but is associated with a high rate of false negative results.
  • molecular diagnosis by a 1228-probe signature using FNA samples was associated with 100% accuracy in a training set and 96% accuracy in a validation set.
  • molecular classifier provided accurate diagnosis in 4 out of 5 samples for which the cytological exam was not conclusive.
  • the 1228-probe signature could be a complementary tool to cytological exam for the breast cancer diagnosis. This tool could allow avoiding biopsies and unnecessary surgery in patients with benign lesions of the breast.
  • the splice array technology allowed the development of an exon signature for breast cancer diagnosis.

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Abstract

The invention relates to the use of a multiplicity of polynucleotide probe sets, the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of the multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, for determining the variation of expression at least 12 genes, and their variants when present, in order to diagnose the benign or malignant state of a breast tumor.

Description

The present invention describes a molecular in vitro diagnosis of breast cancers. More particularly, the invention relates to the use of molecular probes for the diagnosis evaluation of breast tumors.
Breast Cancer is the most frequent cancer in women in western countries (40,000 new cases in France/year). Although several advances have been achieved in the last 10 years the mortality rates remain high (11,000 death/year in France). There is therefore a need for a new generation of advances in this disease. Two axes have allowed improvement of breast cancer survival rates: i. an earlier and more accurate diagnosis, ii. the development of adjuvant therapies.
Breast Cancer diagnosis is currently performed in a vast majority of cases by a preoperative core needle biopsy. This exam is currently considered as a level 1 recommendation in France (www.has-sante.fr). In selected centers that are experts in this field, a fine needle aspiration is used to perform breast cancer diagnosis. Overall, the preoperative diagnosis of breast cancer is currently allowed by microscopic assessment of samples obtained either fine needle aspiration (FNA) or core needle biopsy (CNB). Each of this approach presents some limitations that hamper the quality of care in patients who present a breast lesion. FNA is associated with an unacceptable rate of misdiagnosis. The rate of uncertain diagnosis is indeed around 30% (Oyama T, Koibuchi Y, McKee G. Core needle biopsy (CNB) as a diagnostic method for breast lesions: comparison with fine needle aspiration cytology (FNA). Breast Cancer. 2004; 11(4):339-42; Orell S R, Farshid G. False-positive reports in fine needle biopsy of breast lesions. Pathology. 2001 November; 33(4):428-36; Meunier M, Clough K. Fine needle aspiration cytology versus percutaneous biopsy of nonpalpable breast lesions. Eur J Radiol. 2002 April; 42(1):10-6). CNB exhibits better performance for diagnosis but is associated with some major limitations. First, since CNB is a complex procedure, the appointments are usually given several weeks after detection of breast lesions. This induces a delayed diagnosis and therefore treatment. With the increase of mass screening, this delay will probably increase over time. Second, the CNB is associated with clinical side effects. The rate of hematoma related to the procedure indeed range between 0.6 and 4% (Barreau B, Tastet S, Lakdja F, Henriques C, Valentin F, Labat M J, Dilhuydy M H. [Patients' information in percutaneous core breast biopsy] Bull Cancer. 2005 March; 92(3):257-65). In addition, CNB is associated is a more painful procedure as compared to FNA. Finally, CNB is an expensive procedure for a frequent disease (200 Euros/procedure). Overall, from these considerations rises the need for a diagnostic test performed on FNA samples that would be accurate, quick and cost-saving. This test could either substitute cytological exam of FNA sample or be performed in complement to this one. This test would allow an earlier, safer and cost-saving diagnosis procedure.
Regarding mass screening, mammogram is currently considered as the gold standard for mass screening. Nevertheless, this approach is limited by a high rate of false negative results, especially in young women and in aggressive tumors. In addition, mammogram is limited by the fact that a significant proportion of women do not perform the test. These considerations point out the need for a screening test that would be better or complementary to mammogram and that would be based on an easier procedure.
So, there is a need to provide test for the patients to diagnose and give a diagnosis of the status of the breast tumor detected.
Many methods based on the knowledge of the molecular mechanism of the breast tumor evolution have been extensively described. These methods describe in particular large-scale process for the determination of variation of expression of genes, or proteins, which can define a hallmark of the breast tumor evolution.
WO 2007/048978 describes methods and compositions for the detection of molecular markers in order to diagnose cancer. In particular, this document describes methods and compositions that can be used to detect the presence or evolution of a breast tumor in a patient.
However, this document discloses in particular micro-arrays for the evaluation of miss-regulated expressed genes, without interest for the expression of variants of genes.
WO 2004/065545 discloses a diagnostic and prognostic method of the breast cancer tumor status, wherein said method consists to compare the expression profile of at least 5 genes of a determined list of 70 genes to the expression profile of said at least 5 genes of a determined list of 70 genes of a control tumor.
However, this document never teaches that the disclosed method can detect splicing variant of the mentioned at least 5 genes chosen among the list of 70 genes to determine the breast cancer status of a tumor.
The setting-up of new arrays to analyse the large-scale expression of exons allows a highly accurate identification of differential molecular events between two conditions. This approach not only analyzes genes differentially expressed (as it is the case with conventional DNA array) but also the differential splicing events. Applied to breast cancer, this large scale analysis could identify differential expression of gene sequences between cancer and benign lesions. Based on these data, it would be possible to set-up molecular assays that could allow a molecular diagnosis of breast cancer based on FNA samples, that would allow a quick, accurate and cost-saving diagnosis. In addition, this approach could allow to set-up a molecular test for breast cancer screening based on blood samples, ductal lavage or breast sampling by FNA.
One aim of the invention is to provide a molecular diagnosis to determine the status of a breast tumor.
Another aim of the invention provides micro-arrays to determine the benign or malignant status of a breast tumor.
Another aim of the invention provides a method using the micro-array to determine the benign or malignant status of a breast tumor.
The invention also provides a kit for the breast cancer diagnosis.
The invention discloses the use of a multiplicity of polynucleotide probe sets, said multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, each nucleic acid sequence specifically hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
    • each given gene, when it presents NO variant, comprising at least one target region, the nucleic acid sequence of which is chosen among SEQ ID NO 2939 TO SEQ ID NO 4578, said target region characterizing said gene,
    • each given gene, when it presents at least one variant, comprising at least two target regions such that:
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is present in a given variant of said gene,
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is either absent in a given variant or is present in a configuration that differs from the one of said gene,
      • said two target regions characterizing said gene,
    • each variant of a given gene presenting at least one target region, said target region being such that its respective nucleic acid sequence is chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
      • each variant is characterized by:
        • either the combination of the presence of at least one target region also present in the gene, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, and the absence of at least one target region present in the gene the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
        • or the presence of a target region, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, said target region presenting a configuration that does not naturally exist in the gene,
      • each polynucleotide probe of a polynucleotide probe set hybridizes with a specific nucleic acid sequence contained in a given target region of the target regions characterizing a given gene, and/or at least one of its variants when present,
      • each given gene, and its variants when present, is specifically recognized by the polynucleotide probes of at least a given polynucleotide probe set,
      • each polynucleotide probe of a given pool of polynucleotide probe set being such that it hybridizes with a given gene, and/or at least one of its variants when present, and cannot hybridize with any other gene different from said given gene, and cannot hybridize with any other variants of a gene different from said given gene,
    • the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of said multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, of a sub-group comprising 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
    • for determining the variation of expression a gene, and its variants when present, of said sub-group in order to diagnose the benign or malignant state of a breast tumor.
The invention discloses the use of a multiplicity of polynucleotide probe sets,
    • each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, said library comprising or consisting of at least one copy each of the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938,
    • said polynucleotide probes being such that the nucleic acid sequence of each polynucleotide probe specifically hybridizes with the nucleotidic sequence of one target region of one gene, and/or of at least one of its variants when present,
      for determining the variation of the expression of
    • at least 12 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes at least 12 determined genes, when they exist,
    • said 12 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID NOs 5421; 5423; 5432; 5434; 5486; 5491; 5525; 5552; 5599; 5652; 5654 and 5683,
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor,
wherein
    • a) each given gene,
      • a. when it presents no variant, comprises at least one target region, said target region characterizing said gene,
      • b. when it presents one variant, comprises at least one target region, said target region characterizing said gene and its variant, and preferably said variant being characterized by the fact that its nucleic acid sequence is shorter than the nucleic acid sequence of said gene,
      • c. when it presents at least two variants, comprises at least two target regions, said two target regions characterizing said gene, such that:
        • i. at least one of the respective polynucleotidic sequences of said target region is present in a given variant of said gene, and
        • ii. at least one of the respective polynucleotidic sequences of said target region is either
          • absent in a given variant, or
          • present in a given variant in a configuration that differs from the one of said gene,
          • preferably said variant being characterized such that its nucleic acid sequence is shorter than the nucleic acid of said gene,
    • b) each variant of a given gene presents at least one target region,
    • and
      • if said variant is the unique variant of a gene, said variant has the same target as said gene, and
      • if said variant is one of the variants of a gene that has at least two variants, each variant of said gene is characterized by either:
        • a. the combination of the presence of at least one target region also present in the gene, and the absence of at least one target region present in the gene, or
        • b. the combination of the presence of at least one target region also present in the gene, and the presence of a target region, said target region presenting a configuration that does not naturally exist in the gene,
    • c) the nucleotidic sequence of each given gene, and its variants when present, is specifically recognized by the nucleic acid sequences of polynucleotide probes contained in at least one given polynucleotide probe set,
    • d) the nucleic acid sequence of each polynucleotide probe of a polynucleotide probe set hybridizes with a specific polynucleotidic sequence contained in a given target region of the target regions which characterize a given gene, and/or at least one of its variants when present,
    • e) the nucleic acid sequence of each polynucleotide probe of a given pool of polynucleotide probe set being such that
      • a. it hybridizes with the nucleotidic sequence of a given gene, and/or of at least one of its variants when present, and
      • b. cannot hybridize with
        • i. the nucleotidic sequence of any other gene different from said given gene, and
        • ii. the nucleotidic sequence of any other variants of a gene different from said given gene,
      • with the proviso that said gene, and its variants when present, is not KRT17, LOC440421, KRT6C and KRT6A, said genes being respectively represented by SEQ ID NO 5431; 5689; 5651 and 5682.
In the case of KRT17, LOC440421, KRT6C and KRT6A genes, said genes being respectively represented by SEQ ID NO 5431; 5689; 5651 and 5682, the above mentioned definition of the nucleic acid sequence of each polynucleotide probe of a given pool of polynucleotide probe set applies with the exception that:
    • 1—polynucleotide probes of a given pool of polynucleotide probe set recognizing KRT17 can hybridize with LOC440421 and at least one of its variant when present,
    • 2—polynucleotide probes of a given pool of polynucleotide probe set recognizing LOC440421 can hybridize with KRT17 and at least one of its variant when present,
    • 3—polynucleotide probes of a given pool of polynucleotide probe set recognizing KRT6C can hybridize with KRT6A and at least one of its variant when present, and
    • 4—polynucleotide probes of a given pool of polynucleotide probe set recognizing KRT6A can hybridize with KRT6C and at least one of its variant when present.
The invention is based on the unexpected observation made by the inventors that the variation of expression of some genes, and their variants when they exist, may characterize the evolution of a diagnosed breast tumor. More particularly, the variants of the invention are the products of a differential splicing, or alternative splicing.
The inventors have demonstrated that the variation of expression of at least 12 determined genes of a group of 275 determined genes, and of variants of said at least 12 determined genes when they exist, hallmarks the benign or malignant status of a breast tumor.
Then, the invention describes the use of polynucleotide probes to characterize a benign versus malignant hallmark of a breast tumor, each polynucleotide probe hybridizing specifically with one gene, and at least one of its splicing variants when they exist, said gene splicing variant being able to be recognized by at least one polynucleotide probe.
In genetics, splicing is a modification of genetic information after transcription, in which introns of precursor messenger RNA (pre-mRNA) are removed and exons of precursor messenger RNA are joined. The splicing prepares the pre-mRNA to produce the mature messenger RNA (mRNA), which then undergoes translation as part of the protein synthesis to produce proteins.
Alternative splicing, in the sense of the invention, is the RNA splicing variation mechanism, in which the exons of the pre-mRNA are separated and reconnected so as to produce alternative ribonucleotide arrangements. In this way, alternative splicing uses genetic expression to facilitate the synthesis of a greater variety of transcripts.
When the pre-mRNA has been transcribed from the DNA, it includes several introns and exons. The exons which are retained in the mRNA are determined during the splicing process. The use of alternative splicing factors leads to a modification of the definition of a “gene” and imposes the variant notion.
For example a pre-mRNA containing 3 exons, if it is considered that variants must contain at least one exon of the gene and at least one exon missing of said gene, can hypothetically produce 6 different variants, as the result of alternative splicing.
In the invention, a gene is defined by the fact that it comprises the deoxyribonucleic acid sequence corresponding to the mRNA which results of the transcription of the DNA sequence, and after the splicing process. Then, the gene is characterized in that it comprises all the exons present in the genomic sequence of said gene.
All the 275 genes considered in the invention present a nucleic acid sequence chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
In the invention, there are two alternatives for a gene:
    • said gene is not submitted to alternative splicing, and presents no variants, or
    • said gene presents at least one variant.
In the case of a gene having no variant, this gene can is characterized in the invention by the presence of a target region. This target region corresponds to a nucleic acid sequence contained in the total nucleic acid sequence of the said gene.
In the case of a gene having one variant, this gene is defined by a target region, and its variant is defined by the same target region. The difference between the gene and its variant is preferably determined by the fact that the nucleic acid sequence of said gene is longer than the nucleic acid sequence of its variant.
This recognizing by one target region allows a redundancy of the representativity of said gene. Indeed, the target region contained in a gene having one variant is thus recognized at least twice, i.e. when the gene is present and when the variant of this gene is present. This redundancy enhances the specificity of detection of the gene expression variation.
In the case of a gene having at least two variants, this gene is defined by at least two regions, these two regions characterizing the gene. These regions are therefore present in gene. These regions, also called target regions correspond to nucleic acid sequences contained in the total nucleic acid sequence of said gene. Moreover, these target regions of said gene are located at a different position in the sequence of said gene.
The targets regions that are involved in the invention present a nucleic acid sequence chosen among the group consisting in SEQ ID NO 2939 to SEQ ID NO 4578.
According to the invention, a “variant” is defined as a polynucleotide molecule that differs from the reference polynucleotide molecule (the gene), but retains essential properties. The gene and its variants share similar polynucleotide sequences with, for example, 70% of nucleic acids identity, preferably 80% of nucleic acids identity, preferably 90% of nucleic acids identity and more preferably 95% of nucleic acids identity. The variants of the invention can be also considered as isoforms.
To be considered as a variant of a given gene, a polynucleotide sequence must contain at least one nucleotide sequence present in the said gene, this sequence corresponding to the target sequence defined above.
If a variant is the unique variant of a gene, this variant has the same target region as its gene, preferably with a nucleic acid sequence with a size that is shorter than the size of the nucleic acid sequence of said gene. Since said variant corresponds to a splicing product of a gene, it generally has one or more exons lacking that are present in said gene. Nevertheless, it is possible, in some rare examples, that a variant of a gene has a nucleic acid sequence with a size which is higher than the size of the nucleic acid sequence of said gene.
If a variant is a variant of a gene that has at least two variants, said variant has at least one difference in the presence of a nucleic acid sequence with respect to the given gene nucleic acid sequence. The specific combination of the presence of at least one target sequence and the absence of at least one target sequence defines the specific characteristic of a given variant. Therefore, each variant is defined by a “bar code” corresponding to the diversity of the presence and absence of all the target sequences present in a gene.
For example, if a gene contains 3 exons, all the nucleic acid sequences consisting in least one exon of said gene, and missing at least one of the other 2 exons of the said given gene, are considered as variants of said given gene.
FIG. 1A illustrates this example.
In the invention, a variant of a gene is characterized in that it comprises at least on target region. These target regions corresponds to polynucleotidic sequences chosen among the group consisting in SEQ ID NO 2939 to SEQ ID NO 4578.
So, a given variant of a gene can be characterized with respect to the target sequence by the fact it contains at least a target region, present in the gene corresponding to said variant, and must is devoid of at least one target region, present in the gene corresponding to said variant, only in the case of a gene that has at least two variants.
As defined above, a variant of a gene having at least two variants is then characterized by a bar code which corresponds to a combination of the presence of at least one target region of the gene, corresponding to the variant, and the absence of at least one target region of the gene corresponding to the variant.
A variant can also be alternatively defined. This other definition is supported by the feature of the invention: the alternative splicing.
When a gene, constituted by at least 3 exons, is differentially spliced, in the corresponding variants, some exons are fused to exons which are not naturally fused in the sequence of the gene. For example, in a gene constituted by 3 exons E1, E2 and E3, one variant can be constituted by the fusion of E1 and E3. In the gene, the natural configuration corresponds to the sequence E1-E2-E3. Then the configuration observed in the variant, E1-E3, is considered as a non natural configuration.
In this case, variant presents a sequence that does not exist in the natural configuration of the gene. It generally corresponds to a junction of to distant exons, separated by at least one other exon. If the target region characterizing the variant corresponds to the junction between two exons, naturally distant in the normal configuration in the gene, said target region characterizes specifically said variant. This example is illustrated by FIG. 1B.
Example of genes having, or not, at least one variant are represented in FIG. 3.
According to the invention, polynucleotide probes are used to detect the variation of expression of a gene, and/or its variants when they exist, to determine the status of a breast tumor.
Artificially, polynucleotide probes are grouped to form a polynucleotide probe set. The term “polynucleotide probe set” used in the invention defines a group of polynucleotide probes as described above. A given set of polynucleotide probe contains from one polynucleotide probe to several polynucleotide probes. Preferably, the polynucleotide probe set of the invention contains one polynucleotide probe to three or four polynucleotide probes. Thereby, polynucleotide probes regrouped in a polynucleotide probe set of the invention are able to hybridize to the same target region.
The polynucleotides probes are also brought together to form a “pool of polynucleotide probe sets”. The polynucleotides probes contained in the polynucleotide probe sets of a pool are able to specifically hybridize with nucleic acid sequences of a gene, and/or variants of said gene when they exist.
Alternatively, the polynucleotide probes contained in the polynucleotide probe sets of a pool are able to specifically hybridize neither with nucleic acid sequences of a different gene, nor with nucleic acid sequences of variants of said different gene, when they exist.
However, in few cases, the above definition should be modulated. In the case of genes KRT17 (SEQ ID NO 5431) and LOC440421 (SEQ ID NO 5689), these genes are two different genes, but share a high similarity/identity in their nucleic acid sequence. Thus, these two genes present some gene regions in their nucleic acid sequence which can be identical. If a target region is present in said gene region, therefore, the polynucleotide probe that recognize the target region contained in said gene region will be able to recognize the two genes.
A similar example applies with genes KRT6A (SEQ ID NO 5682) and KRT6C (SEQ ID NO 5651).
Then, polynucleotide probes of a pool of polynucleotide probe sets are able to characterize a gene and its variants. Moreover, a given gene, and its variants when they exist, can be detected only by the polynucleotide probes of the same pool of polynucleotide probe sets.
According to the invention, each gene, and its variants when present, can be detected by all the polynucleotide probes of a probe set. Moreover, each gene can be recognized by all the polynucleotide probes of at least one polynucleotide probe set, i.e. each gene and its variants can be defined by at least one polynucleotide probe set.
A variant can be detected by two polynucleotide probes belonging to two different polynucleotide probe sets, provided that they belong to the same pool of polynucleotide probe set.
The multiplicity, pool, polynucleotide probe set, and polynucleotide probe interconnection are represented in FIG. 2.
Terms “library comprising or consisting of at least one copy each of the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938” means that the library can contain one, or two, or three, or four, or five or six or seven or eight, or nine or ten copies of each polynucleotide probes represented by the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938. Thus, the minimal library contains 2938 polynucleotides probes, and the maximal library contains 29380 polynucleotides probes. Preferably the preferred library of the invention contains 4582 polynucleotides probes.
In the invention, a “benign breast tumor” is any non-cancerous breast abnormality. Some (not all) benign conditions can signal an increased risk for breast cancer. The most common benign breast conditions include fibrocystic breast condition, benign breast tumors, and breast inflammation. Depending on the type of benign breast condition and the patient's medical situation, treatment may or may not be necessary.
In the invention, a “malignant breast tumor refers” to a malignant tumor that has developed from cells in the breast. Malignant tumors penetrate and destroy healthy body tissues. A group of cells within a tumor may also break away and spread to other parts of the body. Cells that spread from one region of the body into another are called metastases.
The term “base” is used to define the components of the DNA or RNA, i.e. deoxyribonucleotides and ribonucleotides respectively.
Terms “nucleic acids”, “nucleic acid molecule”, “nucleic acid sequence”, “polynucleotidic sequence”, and “polynucleotide” are uniformly used to define a chain of bases that characterizing a DNA or an RNA molecule.
In the invention, “polynucleotide probe” represent a fragment of nucleic acid molecule, corresponding to DNA or RNA, with a variable length. The length of the polynucleotide probe is commonly comprised between 15 bases to 1000 bases, and preferably between 20 bases to 500 bases. Advantageously, the polynucleotide probes defined in the invention comprise from 20 bases to 30 bases. These polynucleotide probes are defined by their nucleic acid sequence.
In the invention, terms “multiplicity” and “combination” are used to define a group of polynucleotide probes sets and polynucleotide probes, respectively. Theses groups correspond to an ensemble of probes, or sets of probes, characterized in that they contains similar information.
According to the invention, each nucleic acid sequence corresponding to nucleic acid probe “specifically hybridizes with” a target region of the said gene. These terms mean that each polynucleotide probe is able to hybridize with a gene, and/or its variants when they exist, defined above. The polynucleotide probe thereby hybridizes to single-stranded nucleic acid molecule (gene and/or its variants, which are DNA or RNA) whose nucleic acid sequence allows base pairing due to complementarity between the nucleic acid sequence of the probe and the nucleic acid sequence of the gene and/or variants of said gene. The base pairing (A-T;G-C) is a concept well known by the skilled man in the art.
Each polynucleotide probe is able to hybridize with one gene and/or at least one variant of said gene, in a specific region of said variant called target region.
Said target region is then defined as the region allowing the base pairing between polynucleotide probe and a gene and/or its variants, when they exist.
Thereby, each polynucleotide probe is able to define a gene and/or at least one variant of said gene, when they exist.
According to the invention, each polynucleotide probe specifically hybridizes with a specific nucleic acid sequence contained in the target region. Moreover, each polynucleotide probes can recognizes a sequence overlapping partially with the sequence recognized by another probe of the same polynucleotide probe set.
To sum up, in the invention each gene, or reference transcript, can be expressed differentially in the form of variants. These variants differ from each other by the presence or absence or the variation of a sequence of a specific region: the target region. This region is liable to be recognized by one to three polynucleotide probes, said polynucleotide probes hybridizing with the same target region being brought together in a polynucleotide probe set.
Then, the use of the multiplicity of polynucleotide probe sets of the invention allows to detect the variation of expression of at least 12 determined genes consisting in SEQ ID NO 5421, SEQ ID NO 5423, SEQ ID NO 5432, SEQ ID NO 5434, SEQ ID NO 5486, SEQ ID NO 5491, SEQ ID NO 5525, SEQ ID NO 5552, SEQ ID NO 5599, SEQ ID NO 5652, SEQ ID NO 5654 and SEQ ID NO 5683, and their variants when they exist, of the group of determined genes constituted by genes of the group constituted by SEQ ID NO 5419 to SEQ ID NO 5693, and a skill man in the art can determine if the breast tumor is malignant or benign.
Thereby, if the expression of a given gene and/or at least one of its variants belonging to the group of 12 determined genes corresponds to a “profile” similar to that of a benign tumor, the tumor of the patient will be considered as evolving to a benign status. In contrast, the expression of a gene and/or at least one of its variant belonging to the group of 12 genes corresponds to that of a “profile” similar to a malignant tumor, it will be considered that the tumor is a malignant tumor.
In one embodiment, the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets chosen among 1640 probe sets of polynucleotides, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, each nucleic acid sequence hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
    • each given gene, when it presents NO variant, comprising at least one target region, the nucleic acid sequence of which is chosen among SEQ ID NO 2939 TO SEQ ID NO 4578, said target region characterizing said gene,
    • each given gene, when it presents at least one variant, comprising at least two target regions such that:
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is present in a given variant of said gene,
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is either absent in a given variant or is present in a configuration that differs from the one of said gene,
      • said two target regions characterizing said gene,
      • each variant of a given gene presenting at least one target region, said target region being such that its respective nucleic acid sequence is chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
      • each variant is characterized by:
        • either the combination of the presence of at least one target region also present in the gene, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, and the absence of at least one target region present in the gene the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
        • or the presence of a target region, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, said target region presenting a configuration that does not naturally exist in the gene,
    • each polynucleotide probe of a polynucleotide probe set hybridizes with a specific nucleic acid sequence contained in a given target region of the target regions which characterize a given gene, and/or at least one of its variants when present,
    • each given gene, and its variants when present, is specifically recognized by at least a given polynucleotide probe set,
    • each polynucleotide probe of a given pool of polynucleotide probe set being such that it hybridizes with a given gene, and/or at least one of its variants when present, and cannot hybridize with any other gene different from said given gene, and cannot hybridize with any other variants of a gene different from said given gene,
    • the polynucleotide probes involved in the combination of pools of polynucleotide probe sets of said multiplicity of polynucleotide probe sets being such that each polynucleotide probe specifically hybridizes with one gene, and/or at least one of its variants when present, of a sub-group comprising 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693,
for determining the variation of expression a gene, and its variants when present, of said sub-group in order to diagnose the benign or malignant state of a breast tumor.
In one preferred embodiment, the invention discloses the use of a multiplicity of polynucleotide probe sets defined above, for determining the variation of the expression of at least 20 determined genes of a group of genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693,
    • said 20 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5421; 5423; 5432; 5434; 5457; 5486; 5491; 5513; 5516; 5525; 5532; 5552; 5599; 5616; 5624; 5643; 5652; 5654; 5673 and 5683.
The invention resides in the unexpected observation that the variation of expression of a group of at least 20 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
In another preferred embodiment the invention discloses the use of a multiplicity of polynucleotide probe sets as above defined, for determining the variation of the expression of at least 35 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
    • said 35 determined genes being represented by the following nucleotidic sequences: SEQ ID Nos 5421; 5423; 5431; 5432; 5434; 5440; 5457; 5462; 5470; 5486; 5491; 5505; 5513; 5516; 5525; 5532; 5546; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5624; 5627; 5630; 5643; 5645; 5652; 5654; 5660; 5669; 5673 and 5683.
The invention also resides in the unexpected observation that the variation of expression of a group of at least 35 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
In another preferred embodiment the invention discloses the use of a multiplicity of polynucleotide probe sets previously defined, for determining the variation of the expression of at least 43 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693,
    • said 43 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5421; 5423; 5431; 5432; 5434; 5440; 5455; 5457; 5462; 5470; 5475; 5486; 5491; 5499; 5505; 5513; 5516; 5520; 5525; 5532; 5546; 5549; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5623; 5624; 5627; 5630; 5643; 5645; 5651; 5652; 5654; 5660; 5669; 5673; 5683 and 5686.
The invention also resides in the unexpected observation that the variation of expression of a group of at least 43 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
In another preferred embodiment the invention discloses the use of a multiplicity of polynucleotide probe sets such as defined above, for determining the variation of the expression of at least 206 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
    • said 206 determined genes being represented by the following nucleotidic sequences: SEQ ID Nos 5420; 5421; 5422; 5423; 5425; 5426; 5427; 5428; 5429; 5430; 5431; 5432; 5434; 5435; 5436; 5437; 5438; 5439; 5440; 5441; 5442; 5443; 5444; 5445; 5446; 5447; 5449; 5450; 5451; 5452; 5453; 5454; 5455; 5456; 5457; 5459; 5460; 5461; 5462; 5463; 5465; 5467; 5468; 5470; 5473; 5475; 5476; 5479; 5480; 5482; 5484; 5485; 5486; 5487; 5488; 5489; 5490; 5491; 5492; 5493; 5495; 5496; 5497; 5498; 5499; 5502; 5503; 5505; 5506; 5507; 5508; 5509; 5511; 5512; 5513; 5515; 5516; 5517; 5518; 5519; 5520; 5523; 5524; 5525; 5526; 5528; 5529; 5530; 5531; 5532; 5533; 5534; 5536; 5538; 5539; 5540; 5543; 5544; 5545; 5546; 5547; 5549; 5550; 5552; 5553; 5554; 5556; 5558; 5559; 5560; 5562; 5563; 5564; 5565; 5566; 5567; 5568; 5569; 5570; 5571; 5573; 5574; 5575; 5576; 5577; 5578; 5581; 5582; 5585; 5587; 5588; 5590; 5591; 5593; 5594; 5595; 5597; 5598; 5599; 5600; 5601; 5602; 5603; 5604; 5605; 5606; 5608; 5609; 5610; 5611; 5612; 5613; 5615; 5616; 5617; 5618; 5622; 5623; 5624; 5625; 5627; 5629; 5630; 5631; 5632; 5633; 5634; 5635; 5637; 5638; 5639; 5640; 5641; 5642; 5643; 5644; 5645; 5647; 5648; 5649; 5651; 5652; 5653; 5654; 5656; 5657; 5658; 5660; 5661; 5665; 5667; 5669; 5672; 5673; 5675; 5676; 5677; 5678; 5680; 5681; 5683; 5684; 5686; 5687; 5689 and 5692.
The invention also resides in the unexpected observation that the variation of expression of a group of at least 206 determined genes chosen among 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor, and provide the best results.
In another preferred embodiment the invention discloses the use of a multiplicity of polynucleotide probe sets such as above defined, for determining the variation of the expression of 275 determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693.
The invention also resides in the unexpected observation that the variation of expression of 275 determined genes is sufficient to determine the malignant or the benign status of a breast tumor.
Then, in an advantageous embodiment, the invention describes the use of a multiplicity of polynucleotide probe sets that allow the detection of variation of expression 12 genes, and their variants when they exist, said variation defining the benign or malignant hallmark of the breast tumor.
More particularly, the 12 genes, and their variants when they exist, are represented by their nucleic acid sequences consisting in SEQ ID NO 5421, SEQ ID NO 5423, SEQ ID NO 5432, SEQ ID NO 5434, SEQ ID NO 5486, SEQ ID NO 5491, SEQ ID NO 5525, SEQ ID NO 5552, SEQ ID NO 5599, SEQ ID NO 5652, SEQ ID NO 5654 and SEQ ID NO 5683 and are specifically recognized by their target sequences.
In one preferred embodiment, the invention relates to the use of a multiplicity of polynucleotide probe sets for determining the variation the gene expression as defined above, and of at least one variant of said genes when present, said variant being represented by the nucleic acid sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694, the correspondence between each variant and its corresponding gene being represented in Table 1A-E and in Table 6.
Thus, according to the invention the inventors have demonstrated that the determination of the variation of expression of at least 12 genes chosen among a group of 275 genes, and of at least one variant of each at least 12 genes give a good information about the benign or malignant status of a breast tumor, without important false positives.
Also, others aspects of the invention demonstrate that the study of the variation of expression of:
    • at least 20 determined genes, or
    • at least 35 determined genes, or
    • at least 43 determined genes or
    • at least 206 determined genes
    • of a group of 275 determined genes, and
      the expression of at least one variant of said at least 20 determined genes, or
    • of said at least 35 determined genes, or
    • of said at least 43 determined genes, or
    • of said at least 206 determined genes
      allows to the pathologist to clearly and without ambiguity determine if a breast tumor is, or will be, benign or malignant.
In one particular embodiment, the variation of expression of all the 275 determined genes and at least one of their variant allows the diagnostic.
In another particular embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of at least 12 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 12 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1A.
Table 1A represents the correspondences between the group of 12 determined genes and their corresponding variants.
Gene Name Gene SEQ ID Variants SEQ ID
AK5 SEQ ID NO 5654 SEQ ID NO 4620
COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784;
SEQ ID NO 5242; SEQ ID NO 5384
DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860;
SEQ ID NO 5058; SEQ ID NO 5095;
SEQ ID NO 5150; SEQ ID NO 5381;
SEQ ID NO 5410;
KIT SEQ ID NO 5423 SEQ ID NO 5107
KRT14 SEQ ID NO 5434 SEQ ID NO 4819; SEQ ID NO 4825;
SEQ ID NO 4845; SEQ ID NO 4877;
SEQ ID NO 4891; SEQ ID NO 4969
KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881
KRT5 SEQ ID NO 5432 SEQ ID NO 5279
MYH11 SEQ ID NO 5599 SEQ ID NO 4697; SEQ ID NO 4870;
SEQ ID NO 5361; SEQ ID NO 5365
NRG1 SEQ ID NO 5552 SEQ ID NO 5084
PTN SEQ ID NO 5486 SEQ ID NO 4666
SFRP1 SEQ ID NO 5491 SEQ ID NO 5161
TSHZ2 SEQ ID NO 5652 SEQ ID NO 4962
In another particular embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of at least 20 determined genes of the group of 275 genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 20 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1B.
Table 1B represents the correspondences between the group of 20 determined genes and their corresponding variants.
Gene Name Gene SEQ ID Variants SEQ ID
AK5 SEQ ID NO 5654 SEQ ID NO 5224
C2orf40 SEQ ID NO 5616 SEQ ID NO 4832
C9orf61 SEQ ID NO 5516 SEQ ID NO 4661
CNN1 SEQ ID NO 5457 SEQ ID NO 5181; SEQ ID NO 4666
COL17A1 SEQ ID NO 5683 SEQ ID NO 4739;
SEQ ID NO 4784; SEQ ID NO 5242;
SEQ ID NO 5384
DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860;
SEQ ID NO 4908; SEQ ID NO 5058;
SEQ ID NO 5095; SEQ ID NO 5150;
SEQ ID NO 5381; SEQ ID NO 5410;
SEQ ID NO 5107
DMN SEQ ID NO 5643 SEQ ID NO 4610; SEQ ID NO 5120
EDN3 SEQ ID NO 5673 SEQ ID NO 5405
IL33 SEQ ID NO 5624 SEQ ID NO 4927
KIT SEQ ID NO 5423 SEQ ID NO 5177; SEQ ID NO 4748;
SEQ ID NO 4817; SEQ ID NO 4821;
SEQ ID NO 5152
KRT14 SEQ ID NO 5434 SEQ ID NO 4969
KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881
KRT5 SEQ ID NO 5432 SEQ ID NO 5279; SEQ ID NO 4740;
SEQ ID NO 4819; SEQ ID NO 4825;
SEQ ID NO 4845; SEQ ID NO 4877;
SEQ ID NO 4878; SEQ ID NO 4891
MYH11 SEQ ID NO 5599 SEQ ID NO 4697; SEQ ID NO 4870;
SEQ ID NO 4972; SEQ ID NO 5103;
SEQ ID NO 5323; SEQ ID NO 5361;
SEQ ID NO 5365
NRG1 SEQ ID NO 5552 SEQ ID NO 5084; SEQ ID NO 5413
NTRK2 SEQ ID NO 5532 SEQ ID NO 5121
PIK3C2G SEQ ID NO 5513 SEQ ID NO 5109
PTN SEQ ID NO 5486 SEQ ID NO 5317; SEQ ID NO 4909
SFRP1 SEQ ID NO 5491 SEQ ID NO 5161
TSHZ2 SEQ ID NO 5652 SEQ ID NO 4962; SEQ ID NO 4620;
SEQ ID NO 4694; SEQ ID NO 4786;
SEQ ID NO 4794
In another preferred embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of at least 35 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 35 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1C.
Table 1C represents the correspondences between the group of 35 determined genes and their corresponding variants.
Gene Name Gene SEQ ID Variants SEQ ID
ACTA2 SEQ ID NO 5462 —
AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620;
SEQ ID NO 4658; SEQ ID NO 4694;
SEQ ID NO 4786; SEQ ID NO 4794;
SEQ ID NO 4856; SEQ ID NO 5078;
SEQ ID NO 5224; SEQ ID NO 5391
C2orf40 SEQ ID NO 5616 SEQ ID NO 4832
C9orf61 SEQ ID NO 5516 SEQ ID NO 4661
CNN1 SEQ ID NO 5457 SEQ ID NO 5181
CNTNAP3 SEQ ID NO 5627 SEQ ID NO 4675
COL14A1 SEQ ID NO 5594 SEQ ID NO 5102
COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784;
SEQ ID NO 5242; SEQ ID NO 5384
CRYAB SEQ ID NO 5470 SEQ ID NO 4858
DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860;
SEQ ID NO 4908; SEQ ID NO 5058;
SEQ ID NO 5095; SEQ ID NO 5150;
SEQ ID NO 5381; SEQ ID NO 5387;
SEQ ID NO 5410
DMN SEQ ID NO 5643 SEQ ID NO 4610; SEQ ID NO 5120
DST SEQ ID NO 5660 SEQ ID NO 5309
EDN3 SEQ ID NO 5673 SEQ ID NO 5405
FAM126A SEQ ID NO 5618 SEQ ID NO 5157
FBXL7 SEQ ID NO 5546 SEQ ID NO 4932
GRAMD3 SEQ ID NO 5601 SEQ ID NO 4857
IL33 SEQ ID NO 5624 SEQ ID NO 4927
IRX1 SEQ ID NO 5603 SEQ ID NO 5140
KIT SEQ ID NO 5423 SEQ ID NO 5107; SEQ ID NO 5177
KRT14 SEQ ID NO 5434 SEQ ID NO 4740; SEQ ID NO 4819;
SEQ ID NO 4825; SEQ ID NO 4845;
SEQ ID NO 4877; SEQ ID NO 4878;
SEQ ID NO 4891; SEQ ID NO 4969
KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881
KRT17 SEQ ID NO 5431 SEQ ID NO 4876; SEQ ID NO 4992
KRT5 SEQ ID NO 5432 SEQ ID NO 4748; SEQ ID NO 4817;
SEQ ID NO 4821; SEQ ID NO 4919;
SEQ ID NO 5152; SEQ ID NO 5279
MME SEQ ID NO 5440 SEQ ID NO 4579; SEQ ID NO 5054
MYH11 SEQ ID NO 5599 SEQ ID NO 4697; SEQ ID NO 4870;
SEQ ID NO 4972; SEQ ID NO 5053;
SEQ ID NO 5103; SEQ ID NO 5323;
SEQ ID NO 5361; SEQ ID NO 5365
MYLK SEQ ID NO 5630 SEQ ID NO 5376
NDRG2 SEQ ID NO 5669 SEQ ID NO 4868; SEQ ID NO 4911
NRG1 SEQ ID NO 5552 SEQ ID NO 5084; SEQ ID NO 5148;
SEQ ID NO 5413
NTRK2 SEQ ID NO 5532 SEQ ID NO 5121
PIK3C2G SEQ ID NO 5513 SEQ ID NO 5109
PTN SEQ ID NO 5486 SEQ ID NO 4666; SEQ ID NO 5317
SFRP1 SEQ ID NO 5491 SEQ ID NO 4909; SEQ ID NO 5161
TANK SEQ ID NO 5505 SEQ ID NO 5069
TSHZ2 SEQ ID NO 5652 SEQ ID NO 4962
WIF1 SEQ ID NO 5645 SEQ ID NO 5397
In other preferred embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of at least 43 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 43 determined genes, wherein the correspondence between genes and their variant s is indicated in the following table 1D.
Table 1D represents the correspondences between the group of 43 determined genes and their corresponding variants.
Gene Name Gene SEQ ID Variants SEQ ID
ACTA2 SEQ ID NO 5462 SEQ ID NO 4633; SEQ ID NO 4795;
SEQ ID NO 4956; SEQ ID NO 5052;
SEQ ID NO 5093; SEQ ID NO
AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620;
SEQ ID NO 4658; SEQ ID NO 4694;
SEQ ID NO 4786; SEQ ID NO 4794;
SEQ ID NO 4856; SEQ ID NO 5078;
SEQ ID NO 5224; SEQ ID NO 5391
C2orf40 SEQ ID NO 5616 SEQ ID NO 4832; SEQ ID NO 4862
C9orf61 SEQ ID NO 5516 SEQ ID NO 4661
CNN1 SEQ ID NO 5457 SEQ ID NO 5181; SEQ ID NO 5185
CNTNAP3 SEQ ID NO 5627 SEQ ID NO 4597; SEQ ID NO 4675
COL14A1 SEQ ID NO 5594 SEQ ID NO 5102
COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4784;
SEQ ID NO 5242; SEQ ID NO 5384
CRYAB SEQ ID NO 5470 SEQ ID NO 4858
DKK3 SEQ ID NO 5549 SEQ ID NO 4933; SEQ ID NO 5208
DMD SEQ ID NO 5421 SEQ ID NO 4664; SEQ ID NO 4860;
SEQ ID NO 4908; SEQ ID NO 5058;
SEQ ID NO 5095; SEQ ID NO 5150;
SEQ ID NO 5381; SEQ ID NO 5387;
SEQ ID NO 5410
DMN SEQ ID NO 5643 SEQ ID NO 4610; SEQ ID NO 5120;
SEQ ID NO 5396
DST SEQ ID NO 5660 SEQ ID NO 5309
EDN3 SEQ ID NO 5673 SEQ ID NO 5405
FAM126A SEQ ID NO 5618 SEQ ID NO 5126; SEQ ID NO 5157
FBXL7 SEQ ID NO 5546 SEQ ID NO 4932
GRAMD3 SEQ ID NO 5601 SEQ ID NO 4857
IL33 SEQ ID NO 5624 SEQ ID NO 4927
IRX1 SEQ ID NO 5603 SEQ ID NO 5140
KIT SEQ ID NO 5423 SEQ ID NO 5107; SEQ ID NO 5177
KRT14 SEQ ID NO 5434 SEQ ID NO 4740; SEQ ID NO 4819;
SEQ ID NO 4825; SEQ ID NO 4845;
SEQ ID NO 4877; SEQ ID NO 4878;
SEQ ID NO 4891; SEQ ID NO 4969
KRT15 SEQ ID NO 5475 SEQ ID NO 4619; SEQ ID NO 4867;
SEQ ID NO 4967
KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881
KRT17 SEQ ID NO 5431 SEQ ID NO 4876; SEQ ID NO 4992;
SEQ ID NO 5036
KRT5 SEQ ID NO 5432 SEQ ID NO 4748; SEQ ID NO 4782;
SEQ ID NO 4817; SEQ ID NO 4821;
SEQ ID NO 4827; SEQ ID NO 4919;
SEQ ID NO 4970; SEQ ID NO 5152;
SEQ ID NO 5279; SEQ ID NO 5406
KRT6C SEQ ID NO 5651 SEQ ID NO 4840
MGC70870 SEQ ID NO 5686 SEQ ID NO 5201
MID1 SEQ ID NO 5623 SEQ ID NO 4706
MME SEQ ID NO 5440 SEQ ID NO 4579; SEQ ID NO 4607;
SEQ ID NO 5054
MYH11 SEQ ID NO 5599 SEQ ID NO 4697; SEQ ID NO 4870;
SEQ ID NO 4972; SEQ ID NO 5053;
SEQ ID NO 5103; SEQ ID NO 5323;
SEQ ID NO 5361; SEQ ID NO 5365
MYLK SEQ ID NO 5630 SEQ ID NO 5376
NDRG2 SEQ ID NO 5669 SEQ ID NO 4868; SEQ ID NO 4898;
SEQ ID NO 4911; SEQ ID NO 5010
NRG1 SEQ ID NO 5552 SEQ ID NO 5084; SEQ ID NO 5085;
SEQ ID NO 5148; SEQ ID NO 5395;
SEQ ID NO 5412; SEQ ID NO 5413
NTRK2 SEQ ID NO 5532 SEQ ID NO 5121
PDE1C SEQ ID NO 5520 SEQ ID NO 4657
PIK3C2G SEQ ID NO 5513 SEQ ID NO 5109
PTN SEQ ID NO 5486 SEQ ID NO 4666; SEQ ID NO 5317
SFRP1 SEQ ID NO 5491 SEQ ID NO 4909; SEQ ID NO 5161
TANK SEQ ID NO 5505 SEQ ID NO 5069
TOP2A SEQ ID NO 5455 SEQ ID NO 5153
TP63 SEQ ID NO 5499 SEQ ID NO 4588
TSHZ2 SEQ ID NO 5652 SEQ ID NO 4962
WIF1 SEQ ID NO 5645 SEQ ID NO 5397
In another preferred embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of at least 206 determined genes of the group of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of the variants of said at least 206 determined genes, wherein the correspondence between genes and their variants is indicated in the following table 1E.
Table 1E represents the correspondences between the group of 206 determined genes and their corresponding variants.
Gene Name Gene SEQ ID Variants SEQ ID
A2M SEQ ID NO 5420 SEQ ID NO 4855; SEQ ID NO 4945;
SEQ ID NO 5092; SEQ ID NO 5248;
SEQ ID NO 5328; SEQ ID NO 5363;
SEQ ID NO 5364
ACTA2 SEQ ID NO 5462 SEQ ID NO 4632; SEQ ID NO 4633;
SEQ ID NO 4795; SEQ ID NO 4956;
SEQ ID NO 4959; SEQ ID NO 4981;
SEQ ID NO 5052; SEQ ID NO 5057;
SEQ ID NO 5093; SEQ ID NO 5316;
SEQ ID NO 5350; SEQ ID NO 5369
ACTG2 SEQ ID NO 5463 SEQ ID NO 4774; SEQ ID NO 4777;
SEQ ID NO 4940
ADD3 SEQ ID NO 5588 SEQ ID NO 4629
AK5 SEQ ID NO 5654 SEQ ID NO 4586; SEQ ID NO 4620;
SEQ ID NO 4658; SEQ ID NO 4694;
SEQ ID NO 4786; SEQ ID NO 4794;
SEQ ID NO 4856; SEQ ID NO 5071;
SEQ ID NO 5078; SEQ ID NO 5224;
SEQ ID NO 5391
ALDH7A1 SEQ ID NO 5456 SEQ ID NO 4836
ALKBH3 SEQ ID NO 5641 SEQ ID NO 4756
ANLN SEQ ID NO 5587 SEQ ID NO 4734; SEQ ID NO 4792;
SEQ ID NO 5210
ANXA1 SEQ ID NO 5436 SEQ ID NO 4651; SEQ ID NO 4760;
SEQ ID NO 4888; SEQ ID NO 5066;
SEQ ID NO 5343
ANXA8L2 SEQ ID NO 5465 SEQ ID NO 4901; SEQ ID NO 5018;
SEQ ID NO 5246
APCDD1 SEQ ID NO 5647 SEQ ID NO 4871; SEQ ID NO 5001;
SEQ ID NO 5081; SEQ ID NO 5182
AQP1 SEQ ID NO 5661 SEQ ID NO 4676; SEQ ID NO 4865
ARHGAP26 SEQ ID NO 5560 SEQ ID NO 5215
ARL4A SEQ ID NO 5453 SEQ ID NO 4793; SEQ ID NO 5002;
SEQ ID NO 5004
ARRDC3 SEQ ID NO 5591 SEQ ID NO 4642; SEQ ID NO 4973
ASPM SEQ ID NO 5581 SEQ ID NO 5050
ASPN SEQ ID NO 5573 SEQ ID NO 4854
ATP8B4 SEQ ID NO 5608 SEQ ID NO 4814
B4GALNT4 SEQ ID NO 5656 SEQ ID NO 5007
BCL11A SEQ ID NO 5577 SEQ ID NO 5204
BUB1 SEQ ID NO 5509 SEQ ID NO 5082
C1orf112 SEQ ID NO 5582 SEQ ID NO 5268
C2orf40 SEQ ID NO 5616 SEQ ID NO 4832; SEQ ID NO 4862
C3orf64 SEQ ID NO 5653 SEQ ID NO 4626
C9orf61 SEQ ID NO 5516 SEQ ID NO 4661; SEQ ID NO 4788;
SEQ ID NO 5034; SEQ ID NO 5290
CCNB1 SEQ ID NO 5615 SEQ ID NO 5138
CCNE2 SEQ ID NO 5631 SEQ ID NO 4656
CDKN3 SEQ ID NO 5523 SEQ ID NO 4837
CENPA SEQ ID NO 5467 SEQ ID NO 4637
CENPE SEQ ID NO 5468 SEQ ID NO 5097
CENPF SEQ ID NO 5568 SEQ ID NO 4843; SEQ ID NO 5130
CFI SEQ ID NO 5422 SEQ ID NO 4719; SEQ ID NO 5105
CHST9 SEQ ID NO 5613 SEQ ID NO 4582
CLDN8 SEQ ID NO 5667 SEQ ID NO 4720; SEQ ID NO 4953
CLIP4 SEQ ID NO 5606 SEQ ID NO 5314
CNN1 SEQ ID NO 5457 SEQ ID NO 5079; SEQ ID NO 5181;
SEQ ID NO 5185
CNTNAP3 SEQ ID NO 5627 SEQ ID NO 4597; SEQ ID NO 4675
CNTNAP3B SEQ ID NO 5692 SEQ ID NO 5399
COL14A1 SEQ ID NO 5594 SEQ ID NO 4727; SEQ ID NO 4936;
SEQ ID NO 5102; SEQ ID NO 5326;
SEQ ID NO 5382; SEQ ID NO 5418
COL17A1 SEQ ID NO 5683 SEQ ID NO 4739; SEQ ID NO 4747;
SEQ ID NO 4784; SEQ ID NO 4897;
SEQ ID NO 5008; SEQ ID NO 5242;
SEQ ID NO 5384
CRK SEQ ID NO 5571 SEQ ID NO 4757
CRYAB SEQ ID NO 5470 SEQ ID NO 4611; SEQ ID NO 4685;
SEQ ID NO 4688; SEQ ID NO 4689;
SEQ ID NO 4773; SEQ ID NO 4858;
SEQ ID NO 4863; SEQ ID NO 4894;
SEQ ID NO 4975; SEQ ID NO 5407;
SEQ ID NO 5416
CTHRC1 SEQ ID NO 5639 SEQ ID NO 4598
CX3CL1 SEQ ID NO 5490 SEQ ID NO 4630; SEQ ID NO 4951
DHCR7 SEQ ID NO 5459 SEQ ID NO 5025; SEQ ID NO 5339
DKK3 SEQ ID NO 5549 SEQ ID NO 4624; SEQ ID NO 4831;
SEQ ID NO 4933; SEQ ID NO 4989;
SEQ ID NO 5049; SEQ ID NO 5184;
SEQ ID NO 5205; SEQ ID NO 5207;
SEQ ID NO 5208; SEQ ID NO 5378
DMD SEQ ID NO 5421 SEQ ID NO 4593; SEQ ID NO 4664;
SEQ ID NO 4860; SEQ ID NO 4908;
SEQ ID NO 5058; SEQ ID NO 5095;
SEQ ID NO 5150; SEQ ID NO 5381;
SEQ ID NO 5387; SEQ ID NO 5388;
SEQ ID NO 5389; SEQ ID NO 5410
DMN SEQ ID NO 5643 SEQ ID NO 4610; SEQ ID NO 5120;
SEQ ID NO 5396
DOCK8 SEQ ID NO 5672 SEQ ID NO 4623; SEQ ID NO 4728;
SEQ ID NO 5118
DST SEQ ID NO 5660 SEQ ID NO 4587; SEQ ID NO 4679;
SEQ ID NO 5236; SEQ ID NO 5309;
SEQ ID NO 5336
EDN3 SEQ ID NO 5673 SEQ ID NO 4714; SEQ ID NO 5405
EGR2 SEQ ID NO 5429 SEQ ID NO 5020; SEQ ID NO 5356
ETV1 SEQ ID NO 5518 SEQ ID NO 4730; SEQ ID NO 5080;
SEQ ID NO 5197; SEQ ID NO 5209;
SEQ ID NO 5214; SEQ ID NO 5218;
SEQ ID NO 5241; SEQ ID NO 5329;
SEQ ID NO 5417
ETV5 SEQ ID NO 5511 SEQ ID NO 4999; SEQ ID NO 5330
FAM126A SEQ ID NO 5618 SEQ ID NO 4641; SEQ ID NO 4646;
SEQ ID NO 5126; SEQ ID NO 5157
FAM130A2 SEQ ID NO 5609 SEQ ID NO 5149; SEQ ID NO 5281
FAM13A1 SEQ ID NO 5559 SEQ ID NO 4680; SEQ ID NO 4804;
SEQ ID NO 5293
FBXL7 SEQ ID NO 5546 SEQ ID NO 4932
FDXR SEQ ID NO 5503 SEQ ID NO 5318
FLJ25770 SEQ ID NO 5684 SEQ ID NO 4735
FMO2 SEQ ID NO 5460 SEQ ID NO 4600; SEQ ID NO 5065
FN1 SEQ ID NO 5675 SEQ ID NO 4608; SEQ ID NO 4609;
SEQ ID NO 4636; SEQ ID NO 4649;
SEQ ID NO 4842; SEQ ID NO 5015;
SEQ ID NO 5022; SEQ ID NO 5098;
SEQ ID NO 5141; SEQ ID NO 5164;
SEQ ID NO 5165; SEQ ID NO 5183;
SEQ ID NO 5186; SEQ ID NO 5258;
SEQ ID NO 5307
FRZB SEQ ID NO 5461 SEQ ID NO 5174
FTO SEQ ID NO 5687 SEQ ID NO 4971; SEQ ID NO 5151;
SEQ ID NO 5257
FZD1 SEQ ID NO 5497 SEQ ID NO 4652
GABRP SEQ ID NO 5554 SEQ ID NO 4614; SEQ ID NO 5031;
SEQ ID NO 5061; SEQ ID NO 5067;
SEQ ID NO 5347
GALE SEQ ID NO 5446 SEQ ID NO 4618
GJB3 SEQ ID NO 5602 SEQ ID NO 5262
GLTSCR2 SEQ ID NO 5566 SEQ ID NO 4775; SEQ ID NO 4834;
SEQ ID NO 4872
GPM6B SEQ ID NO 5443 SEQ ID NO 5104
GPR177 SEQ ID NO 5444 SEQ ID NO 5051; SEQ ID NO 5267;
SEQ ID NO 5298
GRAMD3 SEQ ID NO 5601 SEQ ID NO 4587; SEQ ID NO 4857;
SEQ ID NO 4926; SEQ ID NO 4934;
SEQ ID NO 5087; SEQ ID NO 5088;
SEQ ID NO 5240; SEQ ID NO 5291;
SEQ ID NO 5354
GRIA4 SEQ ID NO 5437 SEQ ID NO 4772; SEQ ID NO 5238
GSTA1 SEQ ID NO 5644 SEQ ID NO 4655
GUCY1A3 SEQ ID NO 5438 SEQ ID NO 4716; SEQ ID NO 4886;
SEQ ID NO 4913; SEQ ID NO 5044;
SEQ ID NO 5070
GYPC SEQ ID NO 5473 SEQ ID NO 5133
HNRNPA1 SEQ ID NO 5612 SEQ ID NO 5273
HOXA7 SEQ ID NO 5538 SEQ ID NO 5005
IFNGR1 SEQ ID NO 5430 SEQ ID NO 4925
IGF1 SEQ ID NO 5435 SEQ ID NO 5414
IL33 SEQ ID NO 5624 SEQ ID NO 4927
IMPAD1 SEQ ID NO 5574 SEQ ID NO 5360
INTS8 SEQ ID NO 5575 SEQ ID NO 4724
IRX1 SEQ ID NO 5603 SEQ ID NO 5140
ITM2A SEQ ID NO 5517 SEQ ID NO 4592
KCTD12 SEQ ID NO 5638 SEQ ID NO 5162
KIAA0101 SEQ ID NO 5556 SEQ ID NO 4648; SEQ ID NO 4808;
SEQ ID NO 4809; SEQ ID NO 4904
KIAA2013 SEQ ID NO 5637 SEQ ID NO 4990
KIF11 SEQ ID NO 5512 SEQ ID NO 4988
KIF23 SEQ ID NO 5640 SEQ ID NO 4725; SEQ ID NO 4732;
SEQ ID NO 4899
KIF4A SEQ ID NO 5547 SEQ ID NO 4964
KIT SEQ ID NO 5423 SEQ ID NO 5107; SEQ ID NO 5177
KLHL13 SEQ ID NO 5625 SEQ ID NO 4979
KMO SEQ ID NO 5498 SEQ ID NO 4653
KRT13 SEQ ID NO 5648 SEQ ID NO 5261; SEQ ID NO 5351
KRT14 SEQ ID NO 5434 SEQ ID NO 4740; SEQ ID NO 4818;
SEQ ID NO 4819; SEQ ID NO 4825;
SEQ ID NO 4845; SEQ ID NO 4877;
SEQ ID NO 4878; SEQ ID NO 4891;
SEQ ID NO 4969
KRT15 SEQ ID NO 5475 SEQ ID NO 4619; SEQ ID NO 4645;
SEQ ID NO 4737; SEQ ID NO 4844;
SEQ ID NO 4849; SEQ ID NO 4866;
SEQ ID NO 4867; SEQ ID NO 4869;
SEQ ID NO 4882; SEQ ID NO 4890;
SEQ ID NO 4967; SEQ ID NO 4978;
SEQ ID NO 5147
KRT16 SEQ ID NO 5525 SEQ ID NO 4826; SEQ ID NO 4881
KRT17 SEQ ID NO 5431 SEQ ID NO 4820; SEQ ID NO 4824;
SEQ ID NO 4873; SEQ ID NO 4876;
SEQ ID NO 4920; SEQ ID NO 4992;
SEQ ID NO 5036; SEQ ID NO 5048
KRT19 SEQ ID NO 5476 SEQ ID NO 4750; SEQ ID NO 4941
KRT28 SEQ ID NO 5657 SEQ ID NO 5154
KRT5 SEQ ID NO 5432 SEQ ID NO 4748; SEQ ID NO 4782;
SEQ ID NO 4817; SEQ ID NO 4821;
SEQ ID NO 4823; SEQ ID NO 4827;
SEQ ID NO 4919; SEQ ID NO 4970;
SEQ ID NO 5152; SEQ ID NO 5179;
SEQ ID NO 5277; SEQ ID NO 5279;
SEQ ID NO 5406
KRT6C SEQ ID NO 5651 SEQ ID NO 4840; SEQ ID NO 5310
KRT7 SEQ ID NO 5524 SEQ ID NO 4896; SEQ ID NO 4995
KRT72 SEQ ID NO 5633 SEQ ID NO 5311
LGR4 SEQ ID NO 5585 SEQ ID NO 4764; SEQ ID NO 5116
LMOD1 SEQ ID NO 5544 SEQ ID NO 4710
LMOD1 SEQ ID NO SEQ ID NO 5280
LMOD1 SEQ ID NO SEQ ID NO 5302
LOC147804 SEQ ID NO 5680 SEQ ID NO 5211
LOC440421 SEQ ID NO 5689 SEQ ID NO 5006
LPHN2 SEQ ID NO 5545 SEQ ID NO 4625; SEQ ID NO 5160
LPHN3 SEQ ID NO 5562 SEQ ID NO 5187
MAF SEQ ID NO 5451 SEQ ID NO 4850; SEQ ID NO 5390
MAGED4B SEQ ID NO 5611 SEQ ID NO 5284
MAML2 SEQ ID NO 5617 SEQ ID NO 4862; SEQ ID NO 5156
MAP2K6 SEQ ID NO 5485 SEQ ID NO 4722; SEQ ID NO 4917
MATN2 SEQ ID NO 5479 SEQ ID NO 4677; SEQ ID NO 4861;
SEQ ID NO 5017; SEQ ID NO 5100
MED20 SEQ ID NO 5507 SEQ ID NO 4830
MERTK SEQ ID NO 5536 SEQ ID NO 5124
MFGE8 SEQ ID NO 5530 SEQ ID NO 4580; SEQ ID NO 4711;
SEQ ID NO 4765; SEQ ID NO 4839;
SEQ ID NO 5301
MGC70870 SEQ ID NO 5686 SEQ ID NO 5201
MID1 SEQ ID NO 5623 SEQ ID NO 4698; SEQ ID NO 4699;
SEQ ID NO 4700; SEQ ID NO 4701;
SEQ ID NO 4702; SEQ ID NO 4703;
SEQ ID NO 4705; SEQ ID NO 4706;
SEQ ID NO 5074
MKI67 SEQ ID NO 5480 SEQ ID NO 4754; SEQ ID NO 4790;
SEQ ID NO 4884; SEQ ID NO 4921;
SEQ ID NO 4954
MME SEQ ID NO 5440 SEQ ID NO 4579; SEQ ID NO 4607;
SEQ ID NO 5054
MXI1 SEQ ID NO 5635 SEQ ID NO 5269
MYH11 SEQ ID NO 5599 SEQ ID NO 4602; SEQ ID NO 4697;
SEQ ID NO 4870; SEQ ID NO 4972;
SEQ ID NO 5053; SEQ ID NO 5103;
SEQ ID NO 5323; SEQ ID NO 5361;
SEQ ID NO 5365
MYLK SEQ ID NO 5630 SEQ ID NO 4682; SEQ ID NO 4687;
SEQ ID NO 4931; SEQ ID NO 5358;
SEQ ID NO 5376; SEQ ID NO 5400;
SEQ ID NO 5401
MYO18A SEQ ID NO 5632 SEQ ID NO 4907
NCAPG SEQ ID NO 5597 SEQ ID NO 4630
NDRG2 SEQ ID NO 5669 SEQ ID NO 4601; SEQ ID NO 4715;
SEQ ID NO 4766; SEQ ID NO 4781;
SEQ ID NO 4822; SEQ ID NO 4859;
SEQ ID NO 4868; SEQ ID NO 4898;
SEQ ID NO 4911; SEQ ID NO 4914;
SEQ ID NO 4947; SEQ ID NO 4977;
SEQ ID NO 4986; SEQ ID NO 5010;
SEQ ID NO 5027; SEQ ID NO 5028;
SEQ ID NO 5030; SEQ ID NO 5062;
SEQ ID NO 5194; SEQ ID NO 5198;
SEQ ID NO 5200; SEQ ID NO 5212;
SEQ ID NO 5222; SEQ ID NO 5227;
SEQ ID NO 5229; SEQ ID NO 5234;
SEQ ID NO 5235; SEQ ID NO 5252;
SEQ ID NO 5256; SEQ ID NO 5292;
SEQ ID NO 5304; SEQ ID NO 5342;
SEQ ID NO 5344; SEQ ID NO 5346;
SEQ ID NO 5348; SEQ ID NO 5367
NECAB1 SEQ ID NO 5598 SEQ ID NO 4797
NEFH SEQ ID NO 5593 SEQ ID NO 4976; SEQ ID NO 5266
NEK2 SEQ ID NO 5482 SEQ ID NO 4976
NFIB SEQ ID NO 5526 SEQ ID NO 4628; SEQ ID NO 4767;
SEQ ID NO 4833; SEQ ID NO 5271;
SEQ ID NO 5370; SEQ ID NO 5371
NME4 SEQ ID NO 5519 SEQ ID NO 4806; SEQ ID NO 5372
NR3C2 SEQ ID NO 5439 SEQ ID NO 4606
NRG1 SEQ ID NO 5552 SEQ ID NO 4713; SEQ ID NO 5084;
SEQ ID NO 5085; SEQ ID NO 5086;
SEQ ID NO 5148; SEQ ID NO 5393;
SEQ ID NO 5394; SEQ ID NO 5395;
SEQ ID NO 5412; SEQ ID NO 5413
NTRK2 SEQ ID NO 5532 SEQ ID NO 4946; SEQ ID NO 5056;
SEQ ID NO 5121; SEQ ID NO 5178;
SEQ ID NO 5385; SEQ ID NO 5386
NUSAP1 SEQ ID NO 5570 SEQ ID NO 4639; SEQ ID NO 4768;
SEQ ID NO 4929; SEQ ID NO 5335
ODZ2 SEQ ID NO 5677 SEQ ID NO 4665; SEQ ID NO 5176
OGFRL1 SEQ ID NO 5605 SEQ ID NO 5040
OSR1 SEQ ID NO 5642 SEQ ID NO 4937
P2RY13 SEQ ID NO 5600 SEQ ID NO 4993
PDE1C SEQ ID NO 5520 SEQ ID NO 4657
PDGFRA SEQ ID NO 5533 SEQ ID NO 4918; SEQ ID NO 4938
PELI1 SEQ ID NO 5590 SEQ ID NO 5014
PFKM SEQ ID NO 5425 SEQ ID NO 5380
PIGR SEQ ID NO 5484 SEQ ID NO 4663; SEQ ID NO 4916;
SEQ ID NO 5345
PIK3C2G SEQ ID NO 5513 SEQ ID NO 5109; SEQ ID NO 5345
PKD2 SEQ ID NO 5426 SEQ ID NO 5111; SEQ ID NO 5128
PPP1R14A SEQ ID NO 5622 SEQ ID NO 4592; SEQ ID NO 4721;
SEQ ID NO 5137
PRC1 SEQ ID NO 5502 SEQ ID NO 4631; SEQ ID NO 4744;
SEQ ID NO 4785; SEQ ID NO 4994;
SEQ ID NO 5075; SEQ ID NO 5188;
SEQ ID NO 5191; SEQ ID NO 5312
PRNP SEQ ID NO 5427 SEQ ID NO 4644; SEQ ID NO 4915
PROS1 SEQ ID NO 5428 SEQ ID NO 5206
PTN SEQ ID NO 5486 SEQ ID NO 4666; SEQ ID NO 5317
PTPRZ1 SEQ ID NO 5487 SEQ ID NO 5064; SEQ ID NO 5112;
SEQ ID NO 5125
PTTG1 SEQ ID NO 5506 SEQ ID NO 4885; SEQ ID NO 5073;
SEQ ID NO 5136
PZP SEQ ID NO 5488 SEQ ID NO 4673; SEQ ID NO 4738;
SEQ ID NO 4851; SEQ ID NO 5313
RACGAP1 SEQ ID NO 5550 SEQ ID NO 4589; SEQ ID NO 5237;
SEQ ID NO 5283; SEQ ID NO 5288;
SEQ ID NO 5322
RBMS3 SEQ ID NO 5445 SEQ ID NO 4980
RIC3 SEQ ID NO 5604 SEQ ID NO 4612; SEQ ID NO 5140;
SEQ ID NO 5155; SEQ ID NO 5270
ROPN1B SEQ ID NO 5447 SEQ ID NO 4718; SEQ ID NO 5144
RPL3 SEQ ID NO 5441 SEQ ID NO 4763; SEQ ID NO 4963
RRM2 SEQ ID NO 5452 SEQ ID NO 4691; SEQ ID NO 4798
S100B SEQ ID NO 5534 SEQ ID NO 4798; SEQ ID NO 4948;
SEQ ID NO 4974
S100P SEQ ID NO 5531 SEQ ID NO 4835
SAA1 SEQ ID NO 5665 SEQ ID NO 4690; SEQ ID NO 4813
SAA2 SEQ ID NO 5610 SEQ ID NO 4584; SEQ ID NO 4813;
SEQ ID NO 4816; SEQ ID NO 5170;
SEQ ID NO 5409
SAMD5 SEQ ID NO 5450 SEQ ID NO 5158
SATB1 SEQ ID NO 5489 SEQ ID NO 4709; SEQ ID NO 4815;
SEQ ID NO 4852; SEQ ID NO 4950;
SEQ ID NO 5249; SEQ ID NO 5337
SFRP1 SEQ ID NO 5491 SEQ ID NO 4674; SEQ ID NO 4909;
SEQ ID NO 5161
SFTPD SEQ ID NO 5492 SEQ ID NO 4674
SIRPA SEQ ID NO 5634 SEQ ID NO 4880; SEQ ID NO 4997;
SEQ ID NO 5131; SEQ ID NO 5379
SLC25A27 SEQ ID NO 5508 SEQ ID NO 5253
SLC26A8 SEQ ID NO 5629 SEQ ID NO 4672
SMARCA2 SEQ ID NO 5493 SEQ ID NO 4810
SMC4 SEQ ID NO 5678 SEQ ID NO 4998; SEQ ID NO 5244;
SEQ ID NO 5320
SORBS1 SEQ ID NO 5564 SEQ ID NO 4681
SPARCL1 SEQ ID NO 5515 SEQ ID NO 4585; SEQ ID NO 4693;
SEQ ID NO 4832; SEQ ID NO 4910;
SEQ ID NO 4924; SEQ ID NO 4935;
SEQ ID NO 4939; SEQ ID NO 4960;
SEQ ID NO 4961; SEQ ID NO 5029;
SEQ ID NO 5035; SEQ ID NO 5055;
SEQ ID NO 5059; SEQ ID NO 5090;
SEQ ID NO 5127; SEQ ID NO 5199;
SEQ ID NO 5202; SEQ ID NO 5228;
SEQ ID NO 5230; SEQ ID NO 5232;
SEQ ID NO 5254; SEQ ID NO 5276;
SEQ ID NO 5325; SEQ ID NO 5353
SPG3A SEQ ID NO 5567 SEQ ID NO 4966
SPRY2 SEQ ID NO 5529 SEQ ID NO 4742; SEQ ID NO 4982;
SEQ ID NO 5233
TAGLN SEQ ID NO 5442 SEQ ID NO 4594; SEQ ID NO 4662;
SEQ ID NO 4906; SEQ ID NO 5024;
SEQ ID NO 5082; SEQ ID NO 5355
TANK SEQ ID NO 5505 SEQ ID NO 4895; SEQ ID NO 5069
TESC SEQ ID NO 5576 SEQ ID NO 5360
TF SEQ ID NO 5454 SEQ ID NO 4654; SEQ ID NO 4668;
SEQ ID NO 4669; SEQ ID NO 4758;
SEQ ID NO 4892; SEQ ID NO 5032;
SEQ ID NO 5099; SEQ ID NO 5411
TLE4 SEQ ID NO 5539 SEQ ID NO 4595; SEQ ID NO 4616;
SEQ ID NO 4635; SEQ ID NO 4729;
SEQ ID NO 4733; SEQ ID NO 4889;
SEQ ID NO 5122
TMEM16A SEQ ID NO 5578 SEQ ID NO 4708
TMPRSS2 SEQ ID NO 5528 SEQ ID NO 5231; SEQ ID NO 5247;
SEQ ID NO 5296
TOP2A SEQ ID NO 5455 SEQ ID NO 4686; SEQ ID NO 5153
TP63 SEQ ID NO 5499 SEQ ID NO 4588; SEQ ID NO 4590;
SEQ ID NO 4653; SEQ ID NO 4828;
SEQ ID NO 5043
TPM1 SEQ ID NO 5449 SEQ ID NO 5319
TPM2 SEQ ID NO 5676 SEQ ID NO 4581; SEQ ID NO 4638;
SEQ ID NO 4789; SEQ ID NO 4800;
SEQ ID NO 4983; SEQ ID NO 5366
TPM3 SEQ ID NO 5649 SEQ ID NO 4634; SEQ ID NO 4741;
SEQ ID NO 4769; SEQ ID NO 4771;
SEQ ID NO 4799; SEQ ID NO 4800;
SEQ ID NO 4803; SEQ ID NO 4875;
SEQ ID NO 4985; SEQ ID NO 4987;
SEQ ID NO 5264; SEQ ID NO 5265;
SEQ ID NO 5274; SEQ ID NO 5299;
SEQ ID NO 5308; SEQ ID NO 5315
TPX2 SEQ ID NO 5543 SEQ ID NO 4596; SEQ ID NO 5129
TRIM2 SEQ ID NO 5563 SEQ ID NO 5119
TRIM29 SEQ ID NO 5681 SEQ ID NO 4847; SEQ ID NO 4848;
SEQ ID NO 5333; SEQ ID NO 5357;
SEQ ID NO 5392
TSHZ2 SEQ ID NO 5652 SEQ ID NO 4962
UBAP2L SEQ ID NO 5558 SEQ ID NO 5072
UBE2C SEQ ID NO 5658 SEQ ID NO 5077; SEQ ID NO 5172;
SEQ ID NO 5173; SEQ ID NO 5403;
SEQ ID NO 5404
UBE2T SEQ ID NO 5553 SEQ ID NO 4660; SEQ ID NO 5041
UTRN SEQ ID NO 5540 SEQ ID NO 5091
VIM SEQ ID NO 5495 SEQ ID NO 4643
WIF1 SEQ ID NO 5645 SEQ ID NO 5142; SEQ ID NO 5397;
SEQ ID NO 5415
YWHAZ SEQ ID NO 5496 SEQ ID NO 4749
ZDHHC2 SEQ ID NO 5569 SEQ ID NO 4768; SEQ ID NO 5106;
SEQ ID NO 5260
ZNF462 SEQ ID NO 5595 SEQ ID NO 4851
ZNF521 SEQ ID NO 5565 SEQ ID NO 4723; SEQ ID NO 5195;
SEQ ID NO 5196; SEQ ID NO 5219;
SEQ ID NO 5321; SEQ ID NO 5359
In another particular embodiment, the invention relates to the use as defined above, for the determination of the variation of expression of 275 determined genes represented by SEQ ID NO 5419 to SEQ ID NO 5693, and of at least one of their variants when they exist, wherein the correspondence between genes and their variants is indicated in the following table 6.
Table 6 summarizes the correspondence between all the sequences disclosed in the invention. In this table:
    • SEQ ID NOs 1-2938 represent polynucleotide probes, and targets, variants and genes they can recognize,
    • SEQ ID NOs 2939-4578 represent target regions, and variant and genes containing them, and polynucleotide probes recognizing them,
    • SEQ ID NOs 4579-5418 and SEQ ID NO 5694 represent variants and their corresponding gene, and target they comprises, and also polynucleotide probes recognizing them,
    • SEQ ID NOs 5419-5493 represent genes.
In another preferred embodiment, the invention relates to the use of a multiplicity of polynucleotide probe sets for determining the variation of the gene expression as defined above, and of its variants when present, wherein target regions are characterized by the polynucleotide sequences SEQ ID NO 2939 to 4578, each target region of each gene, and of each variant when they exist, being represented in Table 6.
For example, in the invention, for detecting the variation of expression of the group of at least 12 determined genes of the group of 275 genes, each of the 12 genes has the following target region:
    • AK5 (SEQ ID NO 5654) contains the following target regions: SEQ ID NO 2979 and 2988
    • COL17A1 (SEQ ID NO 5683) contains the following target regions: SEQ ID NO 2944; 2955; 2971; 2973 and 2974,
    • DMD (SEQ ID NO 5421) contains the following target regions: SEQ ID NO 2939; 2940; 2941; 2942; 2943; 2945; 2947; 2949; 2950; 2952; 2953; 2957; 2961; 2962; 2963; 2964; 2970 and 2980,
    • KIT (SEQ ID NO 5423) contains the following target regions: SEQ ID NO 2984; 2946; 2951; 2954; 2958; 2960; 2965; 2969; 2975 and 2978
    • KRT16 (SEQ ID NO 5525) contains the following target regions: SEQ ID NO 2966 and 2972,
    • KRT14 (SEQ ID NO 5434) contains the following target regions: SEQ ID NO 2946; 2951; 2954; 2958; 2960; 2965; 2969; 2975 and 2978,
    • KRT5 (SEQ ID NO 5432) contains the following target regions: SEQ ID NO 2985,
    • MYH11 (SEQ ID NO 5599) contains the following target regions: SEQ ID NO 2948; 2956; 2959; 2967; 2976; 2981; 2982 and 2986,
    • NRG1 (SEQ ID NO 5552) contains the following target regions: SEQ ID NO 2977,
    • PTN (SEQ ID NO 5486) contains the following target regions: SEQ ID NO 2983,
    • SFRP1 (SEQ ID NO 5491) contains the following target regions: SEQ ID NO 2968, and
    • TSHZ2 (SEQ ID NO 5652) contains the following target regions: SEQ ID NO 2987.
With Table 6, knowing gene and variants, it is easy to identify the sequence of the corresponding target region.
In another particular embodiments, the invention discloses the use of a multiplicity of polynucleotide probe sets for determining the variation of the gene expression as defined above, and/or of their variants when present, wherein each polynucleotide probe contained in a polynucleotide probe set is represented by the nucleic acid sequence of the library consisting in SEQ ID NO 1 to SEQ ID NO 2938, the correspondence between each polynucleotide probe and its corresponding target region, said target region corresponding to a gene and its variants when present, being represented in Table 6.
For example, in the invention, for detecting the variation of expression of the group of at least 12 determined genes of the group of 275 genes, each of the 12 genes is recognized by the following polynucleotide probes:
    • AK5 (SEQ ID NO 5654) is recognized by the polynucleotide probes SEQ ID NO 790; 791; 792; 793; 794 and 795,
    • COL17A1 (SEQ ID NO 5683) is recognized by the polynucleotide probes SEQ ID NO 157; 158; 159; 167; 168; 169; 171; 172; 173 and 177,
    • DMD (SEQ ID NO 5421) is recognized by the polynucleotide probes SEQ ID NO 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374 and 375,
    • KIT (SEQ ID NO 5423) is recognized by the polynucleotide probes SEQ ID NO 1081; 1082 and 1083,
    • KRT14 (SEQ ID NO 5434) is recognized by the polynucleotide probes SEQ ID NO 1165; 1158; 1159; 1160; 1161; 1162; 1166; 1167; 1168; 1169; 1170; 1171; 1185; 1186; 1194; 1198; 1199; 1200 and 1203,
    • KRT16 (SEQ ID NO 5525) is recognized by the polynucleotide probes SEQ ID NO 1262; 1263; 1264; 1267; 1268 and 1269,
    • KRT5 (SEQ ID NO 5432) is recognized by the polynucleotide probes SEQ ID NO 1129; 1140 and 1141,
    • MYH11 (SEQ ID NO 5599) is recognized by the polynucleotide probes SEQ ID NO 1522; 1519; 1520; 1521; 1523; 1524; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556 and 1557,
    • NRG1 (SEQ ID NO 5552) is recognized by the polynucleotide probes SEQ ID NO 969; 972 and 981,
    • PTN (SEQ ID NO 5486) is recognized by the polynucleotide probes SEQ ID NO 2026; 2027 and 2028,
    • SFRP1 (SEQ ID NO 5491) is recognized by the polynucleotide probes SEQ ID NO 2179; 2180 and 2181, and
    • TSHZ2 (SEQ ID NO 5652) is recognized by the polynucleotide probes SEQ ID NO 136; 137 and 138.
    • To summarize, for the same example of at least 12 determined genes of the group of 275 genes, the correspondences are the following ones:
    • NRG1 (SEQ ID NO 5552) and one of its variants (SEQ ID 5084) both contain the target region SEQ ID 2977, said target region being recognized by polynucleotide probes SEQ ID NO 969, 972 and 981,
    • PTN (SEQ ID NO 5486) and one of its variants (SEQ ID 4666) both contain the target region SEQ ID 2983, said target region being recognized by polynucleotide probes SEQ ID NO 2026, 2027 and 2028,
    • SFRP1 (SEQ ID NO 5491) and one of its variants (SEQ ID 5161) both contain the target region SEQ ID 2968, said target region being recognized by polynucleotide probes SEQ ID NO 2179, 2180 and 2181,
    • TSHZ2 (SEQ ID NO 5652) and one of its variants (SEQ ID 4962) both contain the target region SEQ ID 2987, said target region being recognized by polynucleotide probes SEQ ID NO 136, 137 and 138,
    • KIT (SEQ ID NO 5423) and one of its variants (SEQ ID 5107) both contain the target region SEQ ID 2984, said target region being recognized by polynucleotide probes SEQ ID NO 1081, 1082 and 1083,
    • KRT16 (SEQ ID NO 5525) and two of its variants (SEQ ID 4826 and 4881) are such as
      • KRT5 and SEQ ID 4826 both contain the target region SEQ ID 2972, said target region being recognized by polynucleotide probes SEQ ID NO 1267, 1268 and 1269, and
      • KRT5 and SEQ ID 4881 both contain the target region SEQ ID 2966, said target region being recognized by polynucleotide probes SEQ ID NO 1262, 1263 and 1264,
    • KRT5 (SEQ ID NO 5432) and one of its variants (SEQ ID 5279) both contain the target region SEQ ID 2985, said target region being recognized by polynucleotide probes SEQ ID NO 1129, 1140 and 1141,
    • KRT14 (SEQ ID NO 5434) and six of its variants (SEQ ID 4819, 4825, 4845, 4877, 4891 and 4969) are such as:
      • KRT14 and SEQ ID 4819 both contain the target regions SEQ ID 2954, 2960 and 2969, said target regions being recognized respectively by polynucleotide probes SEQ ID NO 116 and 1166, SEQ ID NO 1158 and SEQ ID NO 1159, 1160 and 1161
      • KRT14 and SEQ ID 4825 both contain the target regions SEQ ID 2975 and 2978, said target regions being recognized respectively by polynucleotide probes SEQ ID NO 1167, 1168 and 1169 and SEQ ID NO 1162, 1170 and 1171,
      • KRT14 and SEQ ID 4845 both contain the target region SEQ ID 2965, said target region being recognized by polynucleotide probes SEQ ID NO 1203,
      • KRT14 and SEQ ID 4877 both contain the target region SEQ ID 2946, said target region being recognized by polynucleotide probes SEQ ID NO 1198, 1199 and 1200,
      • KRT14 and SEQ ID 4891 both contain the target region SEQ ID 2958, said target region being recognized by polynucleotide probes SEQ ID NO 1185, 1186 and 1194, and
      • KRT14 and SEQ ID 4969 both contain the target region SEQ ID 2951, said target region being recognized by polynucleotide probes SEQ ID NO 1185, 1186 and 1194,
    • MYH11 (SEQ ID NO 5599) and four of its variants (SEQ ID 4697, 4870, 5361 and 5365) are such as:
      • MYH11 and SEQ ID 4697 both contain the target regions SEQ ID NO 2948 and 2986, said target regions being recognized respectively by polynucleotide probes SEQ ID NO 1522; 1523 and 1524, and SEQ ID NO 1519; 1520 and 1521
      • MYH11 and SEQ ID 4870 both contain the target regions SEQ ID 2956, 2959, 2981 and 2982, said target regions being recognized respectively by polynucleotide probes SEQ ID 1551, 1552 and 1553, SEQ ID NO 1523, 1524 and 1557, SEQ ID NO 1551, 1552 and 1553 and SEQ ID NO 1554, 1555 and 1556,
      • MYH11 and SEQ ID 5361 both contain the target region SEQ ID 2967, said target region being recognized by polynucleotide probes SEQ ID NO 1534, 1535 and 1536,
      • MYH11 and SEQ ID 5365 both contain the target region SEQ ID 2976, said target region being recognized by polynucleotide probes SEQ ID NO 1544, 1545 and 1546,
    • AK5 (SEQ ID NO 5654) and one of its variants (SEQ ID 4654) both contain the target regions SEQ ID 2979 and 2988, said target regions being respectively recognized by polynucleotide probes SEQ ID NO 790, 791 and 792, and SEQ ID NO 793, 794 and 795,
    • COL17A1 (SEQ ID NO 5599) and four of its variants (SEQ ID 4739, 4784, 5242 and 5384) are such as:
      • COL17A1 and SEQ ID 4739 both contain the target regions SEQ ID NO 2944 and 2955, said target regions being recognized respectively by polynucleotide probes SEQ ID NO 171; 172 and 173, and SEQ ID NO 177,
      • COL17A1 and SEQ ID 4784 both contain the target region SEQ ID NO 2973, said target region being recognized by polynucleotide probes SEQ ID NO 167, 168 and 169,
      • COL17A1 and SEQ ID 5242 both contain the target region SEQ ID 2974, said target region being recognized by polynucleotide probes SEQ ID NO 167, 168 and 177,
      • COL17A1 and SEQ ID 5384 both contain the target region SEQ ID 2971, said target region being recognized by polynucleotide probes SEQ ID NO 157, 158 and 159,
    • DMD (SEQ ID NO 5421) and seven of its variants (SEQ ID NO 4664, 4860, 5058, 5095, 5150, 5381 and 5410) are such as:
      • DMD and SEQ ID 4664 both contain the target regions SEQ ID NO 294 and 2947, said target regions being recognized respectively by polynucleotide probes SEQ ID NO 312, 313 and 314, and SEQ ID NO 315, 316 and 317
      • DMD and SEQ ID 4860 both contain the target region SEQ ID 2940, said target region being recognized by polynucleotide probes SEQ ID NO 364, 365 and 366,
      • DMD and SEQ ID 5058 both contain the target region SEQ ID 2950, said target region being recognized by polynucleotide probes SEQ ID NO 353, 360 and 361,
      • DMD and SEQ ID 5095 both contain the target regions SEQ ID 2939, 2942, 2945, 2949, 2953, 2961, 2963, 2964 and 2970, said target region being respectively recognized by polynucleotide probes
        • SEQ ID NO 333, 334 and 335,
        • SEQ ID NO 312, 313 and 348,
        • SEQ ID NO 315, 331 and 336,
        • SEQ ID NO 339, 340 and 341,
        • SEQ ID NO 324, 325 and 326,
        • SEQ ID NO 345, 346 and 347,
        • SEQ ID NO 315, 330 and 331,
        • SEQ ID NO 327, 328 and 329, and
        • SEQ ID NO 327, 328 and 329,
      • DMD and SEQ ID 5150 both contain the target region SEQ ID 2980, said target region being recognized by polynucleotide probes SEQ ID NO 368, 374 and 375,
      • DMD and SEQ ID 5381 both contain the target regions SEQ ID 2941, 2952 and 2962, said target regions being respectively recognized by polynucleotide probes SEQ ID NO 364, 365 and 366, SEQ ID NO 315, 316 and 370, and SEQ ID NO 367, 368 and 369,
      • DMD and SEQ ID 5410 both contain the target region SEQ ID 2957, said target region being recognized by polynucleotide probes SEQ ID NO 315, 316 and 370.
Using Table 6, and knowing genes and variants, it is easy to identify the sequence of the corresponding target region and probes.
The invention also relates to the use of a multiplicity of at least 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets, the nucleic acid sequences of the polynucleotide probes contained in said 50 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 136; 137; 138; 157; 158; 159; 167; 168; 169; 171; 172; 173; 177; 312; 313; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374; 375; 790; 791; 792; 793; 794; 795; 969; 972; 981; 1081; 1082; 1083; 1129; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1185; 1186; 1194; 1198; 1199; 1200; 1203; 1262; 1263; 1264; 1267; 1268; 1269; 1519; 1520; 1521; 1522; 1523; 1524; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 2026; 2027; 2028; 2179; 2180 and 2181,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
for the determination of the variation of expression of:
    • at least 12 determined genes belonging to a group of genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes of at least 12 determined genes, when they exist,
    • said 12 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID NOs 5421; 5423; 5432; 5434; 5486; 5491; 5525; 5552; 5599; 5652; 5654 and 5683 and the corresponding variants being represented in table 1A
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
In one preferred embodiment, the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 50 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
Thus, in all the 50 polynucleotide probe sets mentioned above, 143 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
The above mentioned polynucleotide probes contained in the 50 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
In one preferred embodiment, the invention relates to the use of a multiplicity of at least 100 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotides probes contained in said 100 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NO 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 312; 313; 314; 315; 316; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 378; 379; 380; 381; 555; 556; 557; 558; 560; 561; 562; 566; 567; 788; 789; 790; 791; 792; 793; 794; 795; 800; 801; 802; 821; 822; 823; 969; 971; 972; 981; 1056; 1057; 1058; 1075; 1076; 1077; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1198; 1199; 1200; 1201; 1202; 1203; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1509; 1510; 1511; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1561; 1562; 1682; 1683; 1684; 1776; 1777; 1778; 2023; 2024; 2025; 2026; 2027; 2028; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2762; 2763; 2764; 2860; 2861; 2862; 2883; 2884 and 2885,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
for the determination of the variation of expression of
    • at least 20 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes at least 20 determined genes, when they exist,
    • said 20 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5421; 5423; 5432; 5434; 5457; 5486; 5491; 5513; 5516; 5525; 5532; 5552; 5599; 5616; 5624; 5643; 5652; 5654; 5673 and 5683 and the corresponding variants being represented in table 1B
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
In one preferred embodiment, the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 100 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
Thus, in all the 100 polynucleotide probe sets mentioned above, 282 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
The above mentioned polynucleotide probes contained in the 100 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
In another preferred embodiment, the invention relates to the use of a multiplicity of at least 150 polynucleotide probe sets as previously defined, the nucleic acid sequence of the polynucleotides probes contained in said 150 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 197; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 812; 813; 814; 818; 821; 822; 823; 968; 969; 970; 971; 972; 981; 1056; 1057; 1058; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1284; 1285; 1315; 1469; 1470; 1471; 1509; 1510; 1511; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1580; 1581; 1582; 1671; 1682; 1683; 1684; 1685; 1686; 1690; 1691; 1692; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1952; 1953; 1954; 1963; 2023; 2024; 2025; 2026; 2027; 2028; 2065; 2067; 2088; 2089; 2090; 2091; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2762; 2763; 2764; 2774; 2775; 2776; 2860; 2861; 2862; 2883; 2884 and 2885,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
for the determination of the variation of expression of
    • at least 35 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes at least 35 determined genes, when they exist,
    • said 35 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5421; 5423; 5431; 5432; 5434; 5440; 5457; 5462; 5470; 5486; 5491; 5505; 5513; 5516; 5525; 5532; 5546; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5624; 5627; 5630; 5643; 5645; 5652; 5654; 5660; 5669; 5673 and 5683, and the corresponding variants being represented in table 1C
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
In one preferred embodiment, the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 150 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies.
Thus, in all the 150 polynucleotide probe sets mentioned above, 422 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies.
The above mentioned polynucleotide probes contained in the 150 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
A preferred embodiment of the invention relates to the use of a multiplicity of at least 200 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotide probes contained in said 200 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 121; 122; 123; 130; 131; 132; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 195; 196; 197; 198; 199; 200; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 563; 564; 565; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 809; 810; 811; 812; 813; 814; 815; 816; 817; 818; 821; 822; 823; 824; 825; 826; 840; 841; 845; 846; 847; 868; 968; 969; 970; 971; 972; 973; 974; 975; 976; 977; 981; 1056; 1057; 1058; 1059; 1060; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1084; 1085; 1086; 1087; 1088; 1089; 1094; 1095; 1096; 1103; 1104; 1105; 1110; 1111; 1112; 1114; 1115; 1116; 1123; 1124; 1125; 1126; 1127; 1128; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1229; 1230; 1242; 1243; 1244; 1245; 1250; 1251; 1252; 1262; 1263; 1264; 1265; 1266; 1267; 1268; 1269; 1270; 1271; 1272; 1284; 1285; 1315; 1335; 1407; 1408; 1469; 1470; 1471; 1509; 1510; 1511; 1512; 1513; 1514; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1563; 1564; 1580; 1581; 1582; 1586; 1587; 1588; 1671; 1682; 1683; 1684; 1685; 1686; 1687; 1688; 1689; 1690; 1691; 1692; 1743; 1744; 1745; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1896; 1897; 1898; 1952; 1953; 1954; 1963; 1974; 2023; 2024; 2025; 2026; 2027; 2028; 2061; 2062; 2063; 2065; 2067; 2068; 2072; 2083; 2084; 2085; 2088; 2089; 2090; 2091; 2092; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2381; 2382; 2383; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2601; 2602; 2603; 2762; 2763; 2764; 2774; 2775; 2776; 2778; 2779; 2783; 2794; 2860; 2861; 2862; 2883; 2884 and 2885,
for the determination of the variation of expression of
    • at least 43 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said determined genes at least 43 genes, when they exist,
    • said 43 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5421; 5423; 5431; 5432; 5434; 5440; 5455; 5457; 5462; 5470; 5475; 5486; 5491; 5499; 5505; 5513; 5516; 5520; 5525; 5532; 5546; 5549; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5623; 5624; 5627; 5630; 5643; 5645; 5651; 5652; 5654; 5660; 5669; 5673; 5683 and 5686, and the corresponding variants being represented in table 1D,
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
In one preferred embodiment, the invention relates to the use as defined above, wherein the polynucleotide probes contained in said at least 200 polynucleotide probe sets are as mentioned above and wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284; 1285; 1469; 1470; 1471; 1519; 1520; 1521; 1524; 2065; 2067 and 2089 are present in three copies, SEQ ID NO 1194 is present in 4 copies and SEQ ID NOs 315 and 1162 are present in 6 copies.
Thus, in all the 200 polynucleotide probe sets mentioned above, 565 polynucleotide probes are present, the above mentioned polynucleotide probes being present at least once, and in particular SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284; 1285; 1469; 1470; 1471; 1519; 1520; 1521; 1524; 2065; 2067 and 2089 are present in three copies, SEQ ID NO 1194 is present in 4 copies and SEQ ID NOs 315 and 1162 are present in 6 copies.
The above mentioned polynucleotide probes contained in the 200 nucleotides probe sets specifically recognized the above mentioned gene and their variant when present via target region, the correspondence being deduced from Table 6.
The multiplicities mentioned above are considered as the “Top Polynucleotide Probe Sets”.
In another preferred embodiment, the invention relates to the use of a multiplicity of at least 1228 polynucleotide probe sets as defined above, containing 3985 polynucleotide probes, the nucleic acid sequence of the polynucleotide probes contained in said 1228 polynucleotide probe sets being represented in the first 1228 lines of the Table 7,
for the determination of the variation of expression of for determining the variation of the expression of
    • at least 206 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes at least 206 genes, when they exist,
    • said 206 genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5420; 5421; 5422; 5423; 5425; 5426; 5427; 5428; 5429; 5430; 5431; 5432; 5434; 5435; 5436; 5437; 5438; 5439; 5440; 5441; 5442; 5443; 5444; 5445; 5446; 5447; 5449; 5450; 5451; 5452; 5453; 5454; 5455; 5456; 5457; 5459; 5460; 5461; 5462; 5463; 5465; 5467; 5468; 5470; 5473; 5475; 5476; 5479; 5480; 5482; 5484; 5485; 5486; 5487; 5488; 5489; 5490; 5491; 5492; 5493; 5495; 5496; 5497; 5498; 5499; 5502; 5503; 5505; 5506; 5507; 5508; 5509; 5511; 5512; 5513; 5515; 5516; 5517; 5518; 5519; 5520; 5523; 5524; 5525; 5526; 5528; 5529; 5530; 5531; 5532; 5533; 5534; 5536; 5538; 5539; 5540; 5543; 5544; 5545; 5546; 5547; 5549; 5550; 5552; 5553; 5554; 5556; 5558; 5559; 5560; 5562; 5563; 5564; 5565; 5566; 5567; 5568; 5569; 5570; 5571; 5573; 5574; 5575; 5576; 5577; 5578; 5581; 5582; 5585; 5587; 5588; 5590; 5591; 5593; 5594; 5595; 5597; 5598; 5599; 5600; 5601; 5602; 5603; 5604; 5605; 5606; 5608; 5609; 5610; 5611; 5612; 5613; 5615; 5616; 5617; 5618; 5622; 5623; 5624; 5625; 5627; 5629; 5630; 5631; 5632; 5633; 5634; 5635; 5637; 5638; 5639; 5640; 5641; 5642; 5643; 5644; 5645; 5647; 5648; 5649; 5651; 5652; 5653; 5654; 5656; 5657; 5658; 5660; 5661; 5665; 5667; 5669; 5672; 5673; 5675; 5676; 5677; 5678; 5680; 5681; 5683; 5684; 5686; 5687; 5689 and 5692, and the corresponding variants being represented in table 1E,
      in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
Thus, in all the 1228 polynucleotide probe sets mentioned above, 3427 polynucleotide probes are present.
Also, a preferred embodiment of the invention discloses the use of a multiplicity of 1640 polynucleotide probe sets as defined above, the nucleic acid sequence of the polynucleotide probes contained in said 1640 polynucleotide probe sets being represented in Table 7,
for the determination of the variation of expression of
    • 275 determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes 275 determined genes, when they exist, the correspondence being mentioned in table 6,
    • in order to diagnose in vitro or ex vivo the benign or malignant state of a breast tumor.
Thus, in all the 1640 polynucleotide probe sets mentioned above, 4586 polynucleotide probes are present.
In another embodiment, the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the sub-group of genes is constituted by 12 to 259 genes chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
The sub-groups of genes contain at least 12 genes, as described above. The sub-group of genes can also contain advantageously 19 genes, or advantageously 32 genes, or advantageously 40 genes, or advantageously 214 genes or more advantageously 259 genes.
According to the invention, each gene of the sub-groups of genes, and/or its variants when they exist, are specifically recognized by at least one polynucleotide probe belonging to a polynucleotide probe set of a pool of polynucleotide probe sets.
In a more particular embodiment, the invention relates to the use of a multiplicity of polynucleotide probe sets, wherein the sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
The inventors have unexpectedly demonstrated that a group of 259 genes, and/or their variants when they exist, give some powerful information to precisely determine the benign or malignant status of a breast tumor.
In the group of 259 genes, each gene, and its variants when they exist is specifically recognized by at least one polynucleotide probe belonging to a polynucleotide probe set of a pool of polynucleotide probe sets.
In another advantageous embodiment, the invention discloses the use of a multiplicity of polynucleotide probe sets, wherein the polynucleotide probe sets are chosen among at least 50 polynucleotide probe sets, particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
The multiplicity of polynucleotide probe sets is of at least 50 polynucleotide probe sets, and particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, and more advantageously at least 200 polynucleotide probe sets.
These multiplicities are considered as the “Top Polynucleotide Probe Sets”.
The Top 50 polynucleotide probe sets contains a combination of polynucleotide probes characterized by SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 969, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1129, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1194, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1203, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1520, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2179 and SEQ ID NO 2181.
The Top 100 polynucleotide probe set contains a combination of polynucleotide probes characterized by SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 332, SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 337, SEQ ID NO 338, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 349, SEQ ID NO 350, SEQ ID NO 351, SEQ ID NO 352, SEQ ID NO 353, SEQ ID NO 354, SEQ ID NO 355, SEQ ID NO 356, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 363, SEQ ID NO 364, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 369, SEQ ID NO 371, SEQ ID NO 376, SEQ ID NO 378, SEQ ID NO 379, SEQ ID NO 380, SEQ ID NO 381, SEQ ID NO 555, SEQ ID NO 556, SEQ ID NO 557, SEQ ID NO 558, SEQ ID NO 560, SEQ ID NO 561, SEQ ID NO 562, SEQ ID NO 566, SEQ ID NO 567, SEQ ID NO 788, SEQ ID NO 789, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 800, SEQ ID NO 801, SEQ ID NO 802, SEQ ID NO 821, SEQ ID NO 822, SEQ ID NO 823, SEQ ID NO 969, SEQ ID NO 971, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1056, SEQ ID NO 1057, SEQ ID NO 1058, SEQ ID NO 1075, SEQ ID NO 1076, SEQ ID NO 1077, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1087, SEQ ID NO 1088, SEQ ID NO 1089, SEQ ID NO 1103, SEQ ID NO 1104, SEQ ID NO 1105, SEQ ID NO 1114, SEQ ID NO 1115, SEQ ID NO 1116, SEQ ID NO 1123, SEQ ID NO 1124, SEQ ID NO 1125, SEQ ID NO 1129, SEQ ID NO 1130, SEQ ID NO 1131, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1142, SEQ ID NO 1143, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1163, SEQ ID NO 1163, SEQ ID NO 1164, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1172, SEQ ID NO 1172, SEQ ID NO 1180, SEQ ID NO 1181, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1187, SEQ ID NO 1188, SEQ ID NO 1189, SEQ ID NO 1189, SEQ ID NO 1190, SEQ ID NO 1191, SEQ ID NO 1192, SEQ ID NO 1193, SEQ ID NO 1194, SEQ ID NO 1195, SEQ ID NO 1196, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1201, SEQ ID NO 1202, SEQ ID NO 1203, SEQ ID NO 1207, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1509, SEQ ID NO 1510, SEQ ID NO 1511, SEQ ID NO 1519, SEQ ID NO 1520, SEQ ID NO 1520, SEQ ID NO 1521, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1524, SEQ ID NO 1528, SEQ ID NO 1529, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 1561, SEQ ID NO 1562, SEQ ID NO 1682, SEQ ID NO 1683, SEQ ID NO 1684, SEQ ID NO 1776, SEQ ID NO 1777, SEQ ID NO 1778, SEQ ID NO 2023, SEQ ID NO 2024, SEQ ID NO 2025, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2173, SEQ ID NO 2174, SEQ ID NO 2175, SEQ ID NO 2176, SEQ ID NO 2177, SEQ ID NO 2178, SEQ ID NO 2179, SEQ ID NO 2181, SEQ ID NO 2762, SEQ ID NO 2763, SEQ ID NO 2764, SEQ ID NO 2860, SEQ ID NO 2861, SEQ ID NO 2862, SEQ ID NO 2883, SEQ ID NO 2884 and SEQ ID NO 2885.
The Top 150 polynucleotide probe set contains a combination of polynucleotide probes characterized by polynucleotide probes chosen among SEQ ID NO 1 to SEQ ID NO 2938.
The Top 200 polynucleotide probe set contains a combination of polynucleotide probes characterized by polynucleotide probes chosen among SEQ ID NO 1 to SEQ ID NO 2938.
According to the invention, the multiplicities used can also be represented by a number of at least 300 polynucleotide probe sets, more particularly at least 400 polynucleotide probe sets, more particularly at least 500 polynucleotide probe sets, more particularly at least 600 polynucleotide probe sets, more particularly at least 700 polynucleotide probe sets, more particularly at least 800 polynucleotide probe sets, more particularly at least 900 polynucleotide probe sets, more particularly at least 1000 polynucleotide probe sets, more particularly at least 1100 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, more particularly at least 1400 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets.
All the above-mentioned multiplicities of polynucleotide probe sets contain polynucleotides probes chosen among the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
According to the invention, the 1228 polynucleotide probe sets are an advantageous multiplicity of probe sets defined to diagnose the benign versus malignant status of a breast tumor.
In another embodiment, the invention also relates to the use of a multiplicity of polynucleotide probe sets, wherein polynucleotide probe sets are chosen among at least 50 polynucleotide probe sets, particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probe sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938,
and wherein the sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
According to the invention, the benign versus malignant status of a breast tumor can be determined by the use of 2938 polynucleotide probes.
In an advantageous embodiment, the invention describes the use of a multiplicity of polynucleotide probe sets, wherein a variant of a given gene is chosen among the group of variants consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
According to the invention, each gene can have:
    • no variant
    • at least one variant, as defined above.
In an advantageous embodiment, the invention discloses the use of a multiplicity of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe, each probe being able to specifically hybridize with at least one gene, and/or its variants when they exist, to determine the benign or malignant status of a breast tumor.
More particularly, the invention discloses the use of 2938 polynucleotides probes, assembled in polynucleotide probe sets, said polynucleotides probes being able to detect the variation of expression of at least one gene chosen among 259 genes, and/or its variants when present. According to the invention, the variation of expression of at least 839 variants and the variation of expression 259 genes can be detected by the use of the multiplicities of polynucleotide probe sets described above.
The invention also discloses a library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
This library consists in all the polynucleotide probes that can be regrouped in 1640 representative probe sets of the invention. Then, the library consists in a group that contains 2938 polynucleotide probes.
The invention advantageously discloses a multiplicity of polynucleotide probes sets chosen among the nucleic acid sequences of the library described above, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 214 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
The group of polynucleotide probes represents a combination of 1228 polynucleotide probe sets. The group allows to detect the variation of expression of 214 genes and/or their variants when they exist.
The invention advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 40 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
The group of polynucleotide probes represents a combination of 200 polynucleotide probe sets. The group allows to detect the variation of expression of 40 genes and/or their variants when they exist.
The invention more advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 32 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
The group of polynucleotide probes represents a combination of 150 polynucleotide probe sets. The group allows to detect the variation of expression of 32 genes and/or their variants when they exist.
The invention more advantageously discloses multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 19 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
According to the invention, the set of polynucleotide probe being able to specifically hybridize with 19 genes, and/or their variants when they exist, comprises the polynucleotide probes consisting in SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 332, SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 337, SEQ ID NO 338, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 349, SEQ ID NO 350, SEQ ID NO 351, SEQ ID NO 352, SEQ ID NO 353, SEQ ID NO 354, SEQ ID NO 355, SEQ ID NO 356, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 363, SEQ ID NO 364, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 369, SEQ ID NO 371, SEQ ID NO 376, SEQ ID NO 378, SEQ ID NO 379, SEQ ID NO 380, SEQ ID NO 381, SEQ ID NO 555, SEQ ID NO 556, SEQ ID NO 557, SEQ ID NO 558, SEQ ID NO 560, SEQ ID NO 561, SEQ ID NO 562, SEQ ID NO 566, SEQ ID NO 567, SEQ ID NO 788, SEQ ID NO 789, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 800, SEQ ID NO 801, SEQ ID NO 802, SEQ ID NO 821, SEQ ID NO 822, SEQ ID NO 823, SEQ ID NO 969, SEQ ID NO 971, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1056, SEQ ID NO 1057, SEQ ID NO 1058, SEQ ID NO 1075, SEQ ID NO 1076, SEQ ID NO 1077, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1087, SEQ ID NO 1088, SEQ ID NO 1089, SEQ ID NO 1103, SEQ ID NO 1104, SEQ ID NO 1105, SEQ ID NO 1114, SEQ ID NO 1115, SEQ ID NO 1116, SEQ ID NO 1123, SEQ ID NO 1124, SEQ ID NO 1125, SEQ ID NO 1129, SEQ ID NO 1130, SEQ ID NO 1131, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1142, SEQ ID NO 1143, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1163, SEQ ID NO 1163, SEQ ID NO 1164, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1172, SEQ ID NO 1172, SEQ ID NO 1180, SEQ ID NO 1181, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1187, SEQ ID NO 1188, SEQ ID NO 1189, SEQ ID NO 1189, SEQ ID NO 1190, SEQ ID NO 1191, SEQ ID NO 1192, SEQ ID NO 1193, SEQ ID NO 1194, SEQ ID NO 1195, SEQ ID NO 1196, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1201, SEQ ID NO 1202, SEQ ID NO 1203, SEQ ID NO 1207, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1509, SEQ ID NO 1510, SEQ ID NO 1511, SEQ ID NO 1519, SEQ ID NO 1520, SEQ ID NO 1520, SEQ ID NO 1521, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1524, SEQ ID NO 1528, SEQ ID NO 1529, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 1561, SEQ ID NO 1562, SEQ ID NO 1682, SEQ ID NO 1683, SEQ ID NO 1684, SEQ ID NO 1776, SEQ ID NO 1777, SEQ ID NO 1778, SEQ ID NO 2023, SEQ ID NO 2024, SEQ ID NO 2025, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2173, SEQ ID NO 2174, SEQ ID NO 2175, SEQ ID NO 2176, SEQ ID NO 2177, SEQ ID NO 2178, SEQ ID NO 2179, SEQ ID NO 2181, SEQ ID NO 2762, SEQ ID NO 2763, SEQ ID NO 2764, SEQ ID NO 2860, SEQ ID NO 2861, SEQ ID NO 2862, SEQ ID NO 2883, SEQ ID NO 2884 and SEQ ID NO 2885
The group of polynucleotide probes represents a combination of 100 polynucleotide probe sets. The group allows to detect the variation of expression of 19 genes and/or their variants when they exist.
The invention advantageously discloses a multiplicity of polynucleotide probe sets chosen among the nucleic acid sequences of the library according to claim 8, wherein the multiplicity of polynucleotide probe sets represents a combination of pool of polynucleotide probe sets able to specifically hybridize with 12 genes, and/or their variants when they exist, chosen among SEQ ID NO 5419 to SEQ ID NO 5677.
According to the invention, the set of polynucleotide probe being able to specifically hybridize with 12 genes, and/or their variants when they exist, comprises the polynucleotide probes consisting in SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 969, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1129, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1194, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1203, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1520, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2179 and SEQ ID NO 2181.
The group of polynucleotide probes represents a combination of 50 polynucleotide probe sets. The group allows to detect the variation of expression of 12 genes and/or their variants when they exist.
The invention also discloses a multiplicity of 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
Also, the invention relates to a multiplicity of at least 50 polynucleotide probe sets chosen among 1640 polynucleotide probe sets, the nucleic acid sequences of the polynucleotide probes contained in said 50 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 136; 137; 138; 157; 158; 159; 167; 168; 169; 171; 172; 173; 177; 312; 313; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374; 375; 790; 791; 792; 793; 794; 795; 969; 972; 981; 1081; 1082; 1083; 1129; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1185; 1186; 1194; 1198; 1199; 1200; 1203; 1262; 1263; 1264; 1267; 1268; 1269; 1519; 1520; 1521; 1522; 1523; 1524; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 2026; 2027; 2028; 2179; 2180 and 2181,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies.
In one preferred embodiment, the invention also discloses a multiplicity of 100 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
Also, the invention relates to a multiplicity of at least 100 polynucleotide probe sets as above defined, the nucleic acid sequences of the polynucleotides probes contained in said 100 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NO 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 312; 313; 314; 315; 316; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 378; 379; 380; 381; 555; 556; 557; 558; 560; 561; 562; 566; 567; 788; 789; 790; 791; 792; 793; 794; 795; 800; 801; 802; 821; 822; 823; 969; 971; 972; 981; 1056; 1057; 1058; 1075; 1076; 1077; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1198; 1199; 1200; 1201; 1202; 1203; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1509; 1510; 1511; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1561; 1562; 1682; 1683; 1684; 1776; 1777; 1778; 2023; 2024; 2025; 2026; 2027; 2028; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2762; 2763; 2764; 2860; 2861; 2862; 2883; 2884 and 2885,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies.
In another preferred embodiment, the invention also discloses a multiplicity of 150 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
In other word, the invention relates to a multiplicity of at least 150 polynucleotide probe sets previously defined, the nucleic acid sequences of the polynucleotides probes contained in said 150 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 197; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 812; 813; 814; 818; 821; 822; 823; 968; 969; 970; 971; 972; 981; 1056; 1057; 1058; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1284; 1285; 1315; 1469; 1470; 1471; 1509; 1510; 1511; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1580; 1581; 1582; 1671; 1682; 1683; 1684; 1685; 1686; 1690; 1691; 1692; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1952; 1953; 1954; 1963; 2023; 2024; 2025; 2026; 2027; 2028; 2065; 2067; 2088; 2089; 2090; 2091; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2762; 2763; 2764; 2774; 2775; 2776; 2860; 2861; 2862; 2883; 2884 and 2885,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies.
Another preferred embodiment of the invention relates to a multiplicity of 200 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
Indeed, a preferred embodiment of the invention discloses a multiplicity of at least 200 polynucleotide probe sets defined above, the nucleic acid sequences of the polynucleotide probes contained in said 200 polynucleotide probe sets being the following nucleic acid sequences: SEQ ID NOs 4; 5; 6; 120; 121; 122; 123; 130; 131; 132; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 195; 196; 197; 198; 199; 200; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 563; 564; 565; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 809; 810; 811; 812; 813; 814; 815; 816; 817; 818; 821; 822; 823; 824; 825; 826; 840; 841; 845; 846; 847; 868; 968; 969; 970; 971; 972; 973; 974; 975; 976; 977; 981; 1056; 1057; 1058; 1059; 1060; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1084; 1085; 1086; 1087; 1088; 1089; 1094; 1095; 1096; 1103; 1104; 1105; 1110; 1111; 1112; 1114; 1115; 1116; 1123; 1124; 1125; 1126; 1127; 1128; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1229; 1230; 1242; 1243; 1244; 1245; 1250; 1251; 1252; 1262; 1263; 1264; 1265; 1266; 1267; 1268; 1269; 1270; 1271; 1272; 1284; 1285; 1315; 1335; 1407; 1408; 1469; 1470; 1471; 1509; 1510; 1511; 1512; 1513; 1514; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1563; 1564; 1580; 1581; 1582; 1586; 1587; 1588; 1671; 1682; 1683; 1684; 1685; 1686; 1687; 1688; 1689; 1690; 1691; 1692; 1743; 1744; 1745; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1896; 1897; 1898; 1952; 1953; 1954; 1963; 1974; 2023; 2024; 2025; 2026; 2027; 2028; 2061; 2062; 2063; 2065; 2067; 2068; 2072; 2083; 2084; 2085; 2088; 2089; 2090; 2091; 2092; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2381; 2382; 2383; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2601; 2602; 2603; 2762; 2763; 2764; 2774; 2775; 2776; 2778; 2779; 2783; 2794; 2860; 2861; 2862; 2883; 2884 and 2885,
each polynucleotide probe set containing from 1 to 4 of said polynucleotide probes,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284; 1285; 1469; 1470; 1471; 1519; 1520; 1521; 1524; 2065; 2067 and 2089 are present in three copies, SEQ ID NO 1194 is present in 4 copies and SEQ ID NOs 315 and 1162 are present in 6 copies.
Another particular embodiment of the invention relates to a multiplicity of 1228 polynucleotide probe sets chosen among 1640 polynucleotide probe sets as defined above.
The invention, in a particular embodiment, relates to a multiplicity of at least 1228 polynucleotide probe sets as defined above, containing 3985 polynucleotide probes, the nucleic acid sequences of the polynucleotide probes contained in said 1228 polynucleotide probe sets being represented in the first 1228 lines of the Table 7.
The invention discloses, in another preferred embodiment, a multiplicity 1640 polynucleotide probe sets as defined above.
The invention related to a multiplicity of 1640 polynucleotide probe sets as previously defined, the nucleic acid sequences of the polynucleotide probes contained in said 1640 polynucleotide probe sets being represented in Table 7.
The invention also discloses a micro-array comprising or consisting in a multiplicity of polynucleotide probe sets as defined above.
Thus, the invention discloses a micro-array comprising the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or a multiplicity of polynucleotide probe sets:
    • corresponding to a multiplicity of 1228 polynucleotide probe sets comprising nucleic acid sequences chosen among the group consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • corresponding to a multiplicity of 200 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • corresponding to a multiplicity of 150 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • corresponding to a multiplicity of 100 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, and in particular consisting in SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 332, SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 337, SEQ ID NO 338, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 349, SEQ ID NO 350, SEQ ID NO 351, SEQ ID NO 352, SEQ ID NO 353, SEQ ID NO 354, SEQ ID NO 355, SEQ ID NO 356, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 363, SEQ ID NO 364, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 369, SEQ ID NO 371, SEQ ID NO 376, SEQ ID NO 378, SEQ ID NO 379, SEQ ID NO 380, SEQ ID NO 381, SEQ ID NO 555, SEQ ID NO 556, SEQ ID NO 557, SEQ ID NO 558, SEQ ID NO 560, SEQ ID NO 561, SEQ ID NO 562, SEQ ID NO 566, SEQ ID NO 567, SEQ ID NO 788, SEQ ID NO 789, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 800, SEQ ID NO 801, SEQ ID NO 802, SEQ ID NO 821, SEQ ID NO 822, SEQ ID NO 823, SEQ ID NO 969, SEQ ID NO 971, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1056, SEQ ID NO 1057, SEQ ID NO 1058, SEQ ID NO 1075, SEQ ID NO 1076, SEQ ID NO 1077, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1087, SEQ ID NO 1088, SEQ ID NO 1089, SEQ ID NO 1103, SEQ ID NO 1104, SEQ ID NO 1105, SEQ ID NO 1114, SEQ ID NO 1115, SEQ ID NO 1116, SEQ ID NO 1123, SEQ ID NO 1124, SEQ ID NO 1125, SEQ ID NO 1129, SEQ ID NO 1130, SEQ ID NO 1131, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1142, SEQ ID NO 1143, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1163, SEQ ID NO 1163, SEQ ID NO 1164, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1172, SEQ ID NO 1172, SEQ ID NO 1180, SEQ ID NO 1181, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1187, SEQ ID NO 1188, SEQ ID NO 1189, SEQ ID NO 1189, SEQ ID NO 1190, SEQ ID NO 1191, SEQ ID NO 1192, SEQ ID NO 1193, SEQ ID NO 1194, SEQ ID NO 1195, SEQ ID NO 1196, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1201, SEQ ID NO 1202, SEQ ID NO 1203, SEQ ID NO 1207, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1509, SEQ ID NO 1510, SEQ ID NO 1511, SEQ ID NO 1519, SEQ ID NO 1520, SEQ ID NO 1520, SEQ ID NO 1521, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1524, SEQ ID NO 1528, SEQ ID NO 1529, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 1561, SEQ ID NO 1562, SEQ ID NO 1682, SEQ ID NO 1683, SEQ ID NO 1684, SEQ ID NO 1776, SEQ ID NO 1777, SEQ ID NO 1778, SEQ ID NO 2023, SEQ ID NO 2024, SEQ ID NO 2025, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2173, SEQ ID NO 2174, SEQ ID NO 2175, SEQ ID NO 2176, SEQ ID NO 2177, SEQ ID NO 2178, SEQ ID NO 2179, SEQ ID NO 2181, SEQ ID NO 2762, SEQ ID NO 2763, SEQ ID NO 2764, SEQ ID NO 2860, SEQ ID NO 2861, SEQ ID NO 2862, SEQ ID NO 2883, SEQ ID NO 2884 and SEQ ID NO 2885, or
    • corresponding to a multiplicity of 50 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, and in particular consisting in SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 969, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1129, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1194, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1203, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1520, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2179 and SEQ ID NO 2181.
The microarray refers to nucleic acid molecule covalently attached to an inert chemical surface, such as coated glass slides or gene chips, and to which a mobile DNA target is hybridized. All the commonly used surfaces can also serve as a support.
The invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, by determining the variation of the expression of a gene, and/or at least one of its variants when present, of a sub-group comprising at least 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677, comprising:
    • a) contacting nucleic acid molecules from said biological sample a multiplicity of polynucleotide probe sets, said multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, each nucleic acid sequence specifically hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5677,
    • each given gene, when it presents no variant, comprising at least one target region, the nucleic acid sequence of which is chosen among SEQ ID NO 2939 to SEQ ID NO 4578, said target region characterizing said gene,
    • each given gene, when it presents at least one variant, comprising at least two target regions such that:
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is present in a given variant of said gene,
      • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is either absent in a given variant or is present in a configuration that differs from the one of said gene,
    • said two target regions characterizing said gene,
      • each variant of a given gene presenting at least one target region, said target region being such that its respective nucleic acid sequence is chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
      • each variant is characterized by:
        • either the combination of the presence of at least one target region also present in the gene, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, and the absence of at least one target region present in the gene the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
        • or the presence of a target region, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, said target region presenting a configuration that does not naturally exist in the gene,
      • each polynucleotide probe of a polynucleotide probe set hybridizes with a specific nucleic acid sequence contained in a given target region of the target regions which characterize a given gene, and/or at least one of its variants when present,
      • each given gene, and its variants when present, is specifically recognized by at least a given polynucleotide probe set,
      • each polynucleotide probe of a given pool of polynucleotide probe set being such that it hybridizes with a given gene, and/or at least one of its variants when present, and cannot hybridize with any other gene different from said given gene, and cannot hybridize with any other variants of a gene different from said given gene,
    • b) determining a profile of expression variants of said genes from the detection of the nucleic acid complexes formed in the previous step,
    • c) comparing said profile with a reference gene expression variant profile of a control subject,
    • d) concluding, from the previous comparison, the benign or malignant state of the breast cancer in the subject.
Also, the invention relates to a method for the determination, preferably in vitro and/or ex vivo, of the benign or malignant state of a breast tumor in a biological sample from a subject, by determining the variation of the expression of
    • at least 12 determined genes belonging to a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693 and
    • at least one variant of said genes at least 12 determined genes, when they exist,
    • said 12 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID NOs 5421; 5423; 5432; 5434; 5486; 5491; 5525; 5552; 5599; 5652; 5654 and 5683,
comprising:
    • (1) contacting nucleic acid molecules from said biological sample to a multiplicity of polynucleotide probe sets, said multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets, to allow the formation of a nucleic acid complex,
    • each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences, said library comprising or consisting of at least one copy each of the nucleic acids consisting of SEQ ID NO 1 to SEQ ID NO 2938,
    • said polynucleotide probes being such that the nucleic acid sequence of each polynucleotide probe specifically hybridizes with the nucleotidic sequence of one target region of one gene, and/or of at least one of its variants when present,
wherein
    • a) each given gene,
      • a. when it presents no variant, comprises at least one target region, said target region characterizing said gene,
      • b. when it presents one variant, comprises at least one target region, said target region characterizing said gene and its variant, and said variant being characterized by the fact that its nucleic acid sequence is shorter than the nucleic acid sequence of said gene,
      • c. when it presents at least two variants, comprises at least two target regions, said two target regions characterizing said gene, such that:
        • iii. at least one of the respective polynucleotidic sequences of said target region is present in a given variant of said gene, and
        • iv. at least one of the respective polynucleotidic sequences of said target region is either
          • absent in a given variant, or
          • present in a given variant in a configuration that differs from the one of said gene,
          • said variant being characterized by the fact that its nucleic acid sequence is shorter than the nucleic acid sequence of said gene,
    • b) each variant of a given gene presents at least one target region,
    • and
      • if said variant is the unique variant of a gene, said variant has the same target than said gene, and
      • if said variant is one of the variants of a gene that has at least two variants, each variant of said gene is characterized by either:
        • a. the combination of the presence of at least one target region also present in the gene, and the absence of at least one target region present in the gene, or
        • b. the combination of the presence of at least one target region also present in the gene, and the presence of a target region, said target region presenting a configuration that does not naturally exist in the gene,
    • c) the nucleotidic sequence of each given gene, and its variants when present, is specifically recognized by the nucleic acid sequences of polynucleotide probes contained in at least one given polynucleotide probe set,
    • d) the nucleic acid sequence of each polynucleotide probe of a polynucleotide probe set hybridizes with a specific polynucleotidic sequence contained in a given target region of the target regions which characterize a given gene, and/or at least one of its variants when present,
    • e) the nucleic acid sequence of each polynucleotide probe of a given pool of polynucleotide probe set being such that
      • a. it hybridizes with the nucleotidic sequence of a given gene, and/or of at least one of its variants when present, and
      • b. cannot hybridize with
        • i. the nucleotidic sequence of any other gene different from said given gene, and
        • ii. the nucleotidic sequence of any other variants of a gene different from said given gene,
    • (2) determining a profile of expression of said genes and of variants of said genes from the detection of the nucleic acid complexes formed in the previous step,
    • (3) comparing said profile with a reference expression profile of a control benign breast tumor, and/or a reference expression profile of a control malignant tumor, and
    • (4) concluding, from the previous comparison, that:
      • if said profile of expression is similar to the reference expression profile of a control benign breast tumor, then the breast cancer is benign, and
      • if said profile of expression is similar to the reference expression profile of a control malignant breast tumor, then the breast cancer is malignant,
      • with the proviso that said gene, and its variants when present, is not KRT17, LOC440421, KRT6C and KRT6A, said genes being respectively represented by SEQ ID NO 5431; 5689; 5651 and 5682.
The invention also describes a method that allows the determination of the status, benign or malignant, of a breast tumor.
In the method of the invention, a biological sample corresponding to a breast tumor is used as a source of nucleic acid molecule. Said biological sample refers to a sample obtained from an organism or from components (e.g., cells) of an organism. The sample may be one of any biological tissue. Frequently the sample could be a “clinical sample” which is a sample derived from a patient. Such samples include, but are not limited to, FNA sample, CNB sample, ductal lavage and blood sample. Biological samples may also include sections of tissues such as frozen sections taken for histological purposes.
The subject from which biological sample is provided is commonly a woman, afflicted, or suspected to be afflicted by a breast tumor. The subject can also be a man, with, or suspected to have, a breast cancer. By extension, all the mammals can be diagnosed by the method provides by the invention, with the proviso that they could develop a breast tumor.
The extraction of the nucleic acid molecules of the samples is managed by a routine protocol used in the art. Advantageously, nucleic acid molecules extracted from the biological sample are RNA.
Then, the method of the invention consists in contacting nucleic acid molecules extracted from the biological sample of a subject, with a multiplicity of polynucleotide probe sets. Each polynucleotide probe set contains at least one polynucleotide probe.
The contact between the polynucleotide probe set, and more particularly the polynucleotide probes contained in each polynucleotide probe set, allows to form a nucleic acid complex between the nucleic acid molecule corresponding to a gene, and/or its variants when they exist, and a polynucleotide probe.
Preferably, before contacting the polynucleotide probes with the nucleic acid molecules, nucleic acid molecules are labeled with any know labeling agents (radioisotopes, enzymes, fluorescent molecule . . . ). The hybridization is made according a standard procedure, by modulating if necessary saline concentration and temperature. The protocol used for hybridization is well known by the skilled man in the art.
The presence and amount of the formed nucleic acid complex is detected, by the detection of hybridized nucleic acid molecules which have been labeled with labeling agent, with a specific detection method fitting to the used labeled agent.
According to the invention, each probe set that have hybridized with labeled nucleic acid molecules allows to attribute a value of hybridization. The given value is dependant of the labeling agent.
The compilation of all the values of hybridization allows to establish a profile that corresponds to the specific feature of the tumor assayed. This result is considered as a hallmark of the tumor assayed.
The tumor profile is compared to a reference profile, in particular profile of tumors deriving from biological sample of non afflicted by breast cancer subjects, or derived from biological sample of a subject afflicted by a benign or a malignant breast tumor. Alternatively, the tumor profile assayed can be compared with tumor profile of patients afflicted by benign breast tumor or malignant breast tumor. Typically, the comparison is made by using software commonly used in this type of comparison, and well known and described in the art.
From the comparison between tumor profile and reference profile, it is possible to determine if the breast tumor derived from the biological sample of a patient is a benign tumor or a malignant tumor.
In an advantageous embodiment, the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein the determination of the variation of the expression of a gene, and/or at least one of its variants when present, of a sub-group comprising at least 12 genes among the genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677, comprises:
    • a) contacting nucleic acid molecules from said biological sample with a multiplicity of polynucleotide probe sets consisting in a combination of pools of polynucleotide probe sets chosen among 1640 probe sets of polynucleotides, each polynucleotide probe set containing at least one polynucleotide probe chosen among a library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, each nucleic acid sequence hybridizing with a gene, and/or at least one of its variants when present, said gene being chosen among the group of genes consisting in SEQ ID NO 5419 to SEQ ID NO 5677,
      • each given gene, when it presents NO variant, comprising at least one target region, the nucleic acid sequence of which is chosen among SEQ ID NO 2939 TO SEQ ID NO 4578, said target region characterizing said gene,
      • each given gene, when it presents at least one variant, comprising at least two target regions such that:
        • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is present in a given variant of said gene,
        • at least one of the respective nucleic acid sequences of said target region chosen among SEQ ID NO 2939 to SEQ ID NO 4578 is either absent in a given variant or is present in a configuration that differs from the one of said gene,
        • said two target regions characterizing said gene,
        • each variant of a given gene presenting at least one target region, said target region being such that its respective nucleic acid sequence is chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
        • each variant is characterized by:
          • either the combination of the presence of at least one target region also present in the gene, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, and the absence of at least one target region present in the gene the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578,
          • or the presence of a target region, the respective nucleic acid sequence of which being chosen among SEQ ID NO 2939 to SEQ ID NO 4578, said target region presenting a configuration that does not naturally exist in the gene,
      • each polynucleotide probe of a polynucleotide probe set hybridizes with a specific nucleic acid sequence contained in a given target region of the target regions which characterize a given gene, and/or at least one of its variants when present,
      • each given gene, and its variants when present, is specifically recognized by at least a given polynucleotide probe set,
      • each polynucleotide probe of a given pool of polynucleotide probe set being such that it hybridizes with a given gene, and/or at least one of its variants when present, and cannot hybridize with any other gene different from said given gene, and cannot hybridize with any other variants of a gene different from said given gene,
    • b) determining a profile of expression variants of said genes from the detection of the nucleic acid complexes formed in the previous step,
    • c) comparing said profile with a reference gene expression variant profile of a control subject,
    • d) concluding, from the previous comparison, the benign or malignant state of the breast cancer in the subject.
In one preferred embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, by determining the variation of the expression of at least 20 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
said 20 determined genes being represented by the following nucleotidic sequences: SEQ ID Nos 5421; 5423; 5432; 5434; 5457; 5486; 5491; 5513; 5516; 5525; 5532; 5552; 5599; 5616; 5624; 5643; 5652; 5654; 5673 and 5683.
In one other preferred embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, by 35 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
    • said 35 determined genes being represented by the following nucleotidic sequences:
SEQ ID Nos 5421; 5423; 5431; 5432; 5434; 5440; 5457; 5462; 5470; 5486; 5491; 5505; 5513; 5516; 5525; 5532; 5546; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5624; 5627; 5630; 5643; 5645; 5652; 5654; 5660; 5669; 5673 and 5683.
Another preferred embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as previously defined, by determining the variation of the expression of at least 43 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
    • said 43 determined genes being represented by the following nucleotidic sequences:
    • 5486; 5491; 5499; 5505; 5513; 5516; 5520; 5525; 5532; 5546; 5549; 5552; 5594; 5599; 5601; 5603; 5616; 5618; 5623; 5624; 5627; 5630; 5643; 5645; 5651; 5652; 5654; 5660; 5669; 5673; 5683 and 5686.
Another particular embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, by determining the variation of the expression of at least 206 determined genes of a group of determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693
    • said 206 determined genes being represented by the following nucleotidic sequences:
    • SEQ ID Nos 5420; 5421; 5422; 5423; 5425; 5426; 5427; 5428; 5429; 5430; 5431; 5432; 5434; 5435; 5436; 5437; 5438; 5439; 5440; 5441; 5442; 5443; 5444; 5445; 5446; 5447; 5449; 5450; 5451; 5452; 5453; 5454; 5455; 5456; 5457; 5459; 5460; 5461; 5462; 5463; 5465; 5467; 5468; 5470; 5473; 5475; 5476; 5479; 5480; 5482; 5484; 5485; 5486; 5487; 5488; 5489; 5490; 5491; 5492; 5493; 5495; 5496; 5497; 5498; 5499; 5502; 5503; 5505; 5506; 5507; 5508; 5509; 5511; 5512; 5513; 5515; 5516; 5517; 5518; 5519; 5520; 5523; 5524; 5525; 5526; 5528; 5529; 5530; 5531; 5532; 5533; 5534; 5536; 5538; 5539; 5540; 5543; 5544; 5545; 5546; 5547; 5549; 5550; 5552; 5553; 5554; 5556; 5558; 5559; 5560; 5562; 5563; 5564; 5565; 5566; 5567; 5568; 5569; 5570; 5571; 5573; 5574; 5575; 5576; 5577; 5578; 5581; 5582; 5585; 5587; 5588; 5590; 5591; 5593; 5594; 5595; 5597; 5598; 5599; 5600; 5601; 5602; 5603; 5604; 5605; 5606; 5608; 5609; 5610; 5611; 5612; 5613; 5615; 5616; 5617; 5618; 5622; 5623; 5624; 5625; 5627; 5629; 5630; 5631; 5632; 5633; 5634; 5635; 5637; 5638; 5639; 5640; 5641; 5642; 5643; 5644; 5645; 5647; 5648; 5649; 5651; 5652; 5653; 5654; 5656; 5657; 5658; 5660; 5661; 5665; 5667; 5669; 5672; 5673; 5675; 5676; 5677; 5678; 5680; 5681; 5683; 5684; 5686; 5687; 5689 and 5692.
In another preferred embodiment, the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, by determining the variation of the expression of 275 determined genes represented by the nucleotidic sequences SEQ ID NO: 5419 to SEQ ID NO: 5693.
Another particular embodiment of the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as defined above, wherein said variant being represented by the nucleic acid sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694, the correspondence between each variant and its corresponding gene being represented in Table 1A-E and Table 6.
In still another embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject as defined above, wherein target regions are characterized by the polynucleotide sequences SEQ ID NO 2939 to 4578, the each target region of each gene, and of each variant when they exist, being represented in Table 6.
In one other preferred embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject such as previously defined, wherein each polynucleotide probe contained in a polynucleotide probe set is represented by the nucleic acid sequence of the library consisting in SEQ ID NO 1 to SEQ ID NO 2938,
the correspondence between each polynucleotide probe and its corresponding target region, said target region corresponding to a gene and its variants when present, being represented in Table 6.
In another advantageous embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein the sub-group of genes is constituted by 12 to 259 genes chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
In another embodiment, the invention discloses a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor described above, wherein the sub-group of genes is constituted by the 259 genes of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677.
In a more particular embodiment, the invention relates to a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor in a biological sample from a subject, wherein said set of polynucleotide probes are chosen among the group consisting in:
at least 50 polynucleotide probe sets, particularly at least 100 polynucleotide probe sets, more particularly at least 150 polynucleotide probes sets, more particularly at least 200 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets and more particularly 1640 polynucleotide probe sets of the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938.
The sub-groups of 50, 100, 150, 200 polynucleotide probe sets are defined as the Top sub-groups allowing to determine the benign or malignant status of the tumor.
It is also disclosed in the invention that the multiplicity of probe sets can be constituted by at least 300 polynucleotide probe sets, more particularly at least 400 polynucleotide probe sets, more particularly at least 500 polynucleotide probe sets, more particularly at least 600 polynucleotide probe sets, more particularly at least 700 polynucleotide probe sets, more particularly at least 800 polynucleotide probe sets, more particularly at least 900 polynucleotide probe sets, more particularly at least 1000 polynucleotide probe sets, more particularly at least 1100 polynucleotide probe sets, more particularly at least 1228 polynucleotide probe sets, more particularly at least 1400 polynucleotide probe sets, and more particularly 1640 polynucleotide probe sets.
All the polynucleotide probes contained in the polynucleotide probe sets used in the method of the invention are chosen among a library of nucleic acid sequences consisting SEQ ID NO 1 to SEQ ID NO 2938.
In one embodiment, the invention discloses a method described above, wherein a variant of a given gene is chosen among the group of variants consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
The method of the invention allows to detect the variation of expression genes, and their variants when they exist, said genes being characterized in that they consist in the nucleic acid sequences chosen among the group consisting in SEQ ID NO 5419 to SEQ ID NO 5677 and said variants being characterized in that they consist in the nucleic acid sequence chosen among the group consisting in SEQ ID NO 4579 to SEQ ID NO 5418.
In the invention, it is also disclosed a method for the in vitro and/or ex vivo determination of the benign or malignant state of a breast tumor, wherein the variation of expression of a gene, and/or at least one of its variants when present, said gene being chosen in the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693, is
    • Over represented (Up-regulated), or
    • Under represented (Down-regulated).
Each gene expression, and expression of its variants if they exist, revealed by the method of the invention corresponds to an expression product of a gene of the group consisting in SEQ ID NO 5419 to SEQ ID NO 5693.
These variants are normally expressed in a subject non afflicted by breast cancer. These variants are also expressed in the biological of subject afflicted by benign breast cancer or malignant breast cancer. Each variant have a specific expression level corresponding to the state of the breast cancer. Each variant can then be overexpressed compare to the same variant expressed in a normal subject, or under expressed comparing to the same variant expressed in a normal subject.
The genes, and/or their variants are up-regulated, preferably when their expression levels are more than 1.7 fold higher than the expression levels of said genes in a patient non afflicted by a breast tumor, and significantly different (preferably with a significant coefficient value of less than 0.05). The genes, and/or their variants are down-regulated, preferably when their expression levels are less than 1.7 fold lower than the expression levels of said genes in a patient non afflicted by a breast tumor, and significantly different (preferably with a significant coefficient value of less than 0.05).
In a particular embodiment, the invention discloses a method described above, wherein the nucleic acid molecules from the biological sample of the subject are mRNA/or cDNA, said mRNA resulting from the expression of the genes consisting in SEQ ID NO 5419 to SEQ ID NO 5693, and/or at least one of their variants when present, represented by the nucleotidic sequences SEQ ID NO 4579 to SEQ ID NO 5418 and SEQ ID NO 5694.
In the invention, nucleic acid molecules are extracted from the biological sample of the subject, prior to be contacted with the set of polynucleotide probes, immobilized in a support.
The extraction and preparation of said nucleic acid molecules from the biological sample of the subject is made with a routine protocol commonly used by a skilled man in the art.
More particularly, the RNA are extracted from the biological sample, eventually, mRNA are isolated from the total RNA. In the case of the use of cDNA, mRNA are reverse-transcripted with a standard procedure.
The invention relates to a kit for the in vitro and/or ex vivo determination of benign or malignant status of a breast tumor, comprising:
    • a multiplicity as defined above, or
    • a microarray as defined above.
The invention relates to a kit for the in vitro and/or ex vivo determination of benign or malignant status of a breast tumor, comprising the following group of polynucleotide probes:
    • SEQ ID NOs 136; 137; 138; 157; 158; 159; 167; 168; 169; 171; 172; 173; 177; 312; 313; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 333; 334; 335; 336; 339; 340; 341; 345; 346; 347; 348; 353; 360; 361; 364; 365; 366; 367; 368; 369; 370; 374; 375; 790; 791; 792; 793; 794; 795; 969; 972; 981; 1081; 1082; 1083; 1129; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1185; 1186; 1194; 1198; 1199; 1200; 1203; 1262; 1263; 1264; 1267; 1268; 1269; 1519; 1520; 1521; 1522; 1523; 1524; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 2026; 2027; 2028; 2179; 2180 and 2181,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 327; 328; 329; 331; 364; 365; 366; 368; 370; 1185; 1186; 1194; 1523; 1524; 1551; 1552 and 1553 are present twice, SEQ ID NO 316 is present in three copies and SEQ ID NO 315 is present in 5 copies, or
    • SEQ ID NO 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 312; 313; 314; 315; 316; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 378; 379; 380; 381; 555; 556; 557; 558; 560; 561; 562; 566; 567; 788; 789; 790; 791; 792; 793; 794; 795; 800; 801; 802; 821; 822; 823; 969; 971; 972; 981; 1056; 1057; 1058; 1075; 1076; 1077; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1198; 1199; 1200; 1201; 1202; 1203; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1509; 1510; 1511; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1544; 1545; 1546; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1561; 1562; 1682; 1683; 1684; 1776; 1777; 1778; 2023; 2024; 2025; 2026; 2027; 2028; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2762; 2763; 2764; 2860; 2861; 2862; 2883; 2884 and 2885,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 316; 317; 327; 329; 330; 353; 361; 364; 365; 366; 367; 368; 369; 370; 821; 822; 823; 1129; 1164; 1185; 1186; 1187; 1188; 1189; 1203; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 328; 331; 1162; 1194; 1519; 1520; 1521 and 1524 are present in three copies and SEQ ID NO 315 is present in 6 copies, or
    • SEQ ID NOs 4; 5; 6; 120; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 197; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 812; 813; 814; 818; 821; 822; 823; 968; 969; 970; 971; 972; 981; 1056; 1057; 1058; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1087; 1088; 1089; 1103; 1104; 1105; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1262; 1263; 1264; 1267; 1268; 1269; 1284; 1285; 1315; 1469; 1470; 1471; 1509; 1510; 1511; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1580; 1581; 1582; 1671; 1682; 1683; 1684; 1685; 1686; 1690; 1691; 1692; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1952; 1953; 1954; 1963; 2023; 2024; 2025; 2026; 2027; 2028; 2065; 2067; 2088; 2089; 2090; 2091; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2762; 2763; 2764; 2774; 2775; 2776; 2860; 2861; 2862; 2883; 2884 and 2885,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 969; 1056; 1057; 1058; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1469; 1470; 1471; 1523; 1551; 1552 and 1553 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1194; 1519; 1520; 1521; 1524 are present in three copies, SEQ ID NO 1162 is present in 4 copies and SEQ ID NO 315 is present in 6 copies, or
    • SEQ ID NOs 4; 5; 6; 120; 121; 122; 123; 130; 131; 132; 136; 137; 138; 154; 155; 156; 157; 158; 159; 167; 168; 169; 171; 172; 173; 174; 175; 176; 177; 195; 196; 197; 198; 199; 200; 248; 254; 255; 305; 306; 307; 312; 313; 314; 315; 316; 317; 324; 325; 326; 327; 328; 329; 330; 331; 332; 333; 334; 335; 336; 337; 338; 339; 340; 341; 345; 346; 347; 348; 349; 350; 351; 352; 353; 354; 355; 356; 360; 361; 362; 363; 364; 365; 366; 367; 368; 369; 370; 371; 374; 375; 376; 377; 378; 379; 380; 381; 513; 514; 515; 552; 553; 554; 555; 556; 557; 558; 559; 560; 561; 562; 563; 564; 565; 566; 567; 783; 784; 785; 788; 789; 790; 791; 792; 793; 794; 795; 796; 797; 798; 799; 800; 801; 802; 803; 804; 805; 806; 807; 808; 809; 810; 811; 812; 813; 814; 815; 816; 817; 818; 821; 822; 823; 824; 825; 826; 840; 841; 845; 846; 847; 868; 968; 969; 970; 971; 972; 973; 974; 975; 976; 977; 981; 1056; 1057; 1058; 1059; 1060; 1061; 1062; 1063; 1064; 1065; 1066; 1067; 1068; 1069; 1070; 1071; 1075; 1076; 1077; 1080; 1081; 1082; 1083; 1084; 1085; 1086; 1087; 1088; 1089; 1094; 1095; 1096; 1103; 1104; 1105; 1110; 1111; 1112; 1114; 1115; 1116; 1123; 1124; 1125; 1126; 1127; 1128; 1129; 1130; 1131; 1139; 1140; 1141; 1158; 1159; 1160; 1161; 1162; 1163; 1164; 1165; 1166; 1167; 1168; 1169; 1170; 1171; 1172; 1174; 1175; 1176; 1180; 1181; 1185; 1186; 1187; 1188; 1189; 1190; 1191; 1192; 1193; 1194; 1195; 1196; 1197; 1198; 1199; 1200; 1201; 1202; 1203; 1204; 1205; 1206; 1207; 1229; 1230; 1242; 1243; 1244; 1245; 1250; 1251; 1252; 1262; 1263; 1264; 1265; 1266; 1267; 1268; 1269; 1270; 1271; 1272; 1284; 1285; 1315; 1335; 1407; 1408; 1469; 1470; 1471; 1509; 1510; 1511; 1512; 1513; 1514; 1515; 1516; 1517; 1519; 1520; 1521; 1522; 1523; 1524; 1528; 1529; 1534; 1535; 1536; 1537; 1538; 1539; 1544; 1545; 1546; 1550; 1551; 1552; 1553; 1554; 1555; 1556; 1557; 1558; 1559; 1560; 1561; 1562; 1563; 1564; 1580; 1581; 1582; 1586; 1587; 1588; 1671; 1682; 1683; 1684; 1685; 1686; 1687; 1688; 1689; 1690; 1691; 1692; 1743; 1744; 1745; 1776; 1777; 1778; 1788; 1789; 1790; 1890; 1891; 1892; 1896; 1897; 1898; 1952; 1953; 1954; 1963; 1974; 2023; 2024; 2025; 2026; 2027; 2028; 2061; 2062; 2063; 2065; 2067; 2068; 2072; 2083; 2084; 2085; 2088; 2089; 2090; 2091; 2092; 2173; 2174; 2175; 2176; 2177; 2178; 2179; 2180; 2181; 2196; 2201; 2229; 2230; 2231; 2381; 2382; 2383; 2536; 2537; 2538; 2576; 2577; 2578; 2599; 2600; 2601; 2602; 2603; 2762; 2763; 2764; 2774; 2775; 2776; 2778; 2779; 2783; 2794; 2860; 2861; 2862; 2883; 2884 and 2885,
preferably, wherein SEQ ID NOs 167; 168; 177; 312; 313; 317; 327; 329; 330; 353; 361; 363; 364; 365; 366; 367; 369; 370; 371; 558; 567; 796; 797; 801; 806; 807; 808; 813; 814; 821; 822; 823; 845; 968; 970; 972; 1056; 1057; 1058; 1085; 1114; 1115; 1116; 1123; 1124; 1125; 1129; 1141; 1163; 1164; 1185; 1186; 1187; 1188; 1189; 1199; 1203; 1523; 1551; 1552; 1553; 1557; 1586; 1587; 1588; 1952; 1953; 1954; 2088; 2090; 2091; 2762; 2763 and 2764 are present twice, SEQ ID NOs 316; 328; 331; 368; 788; 1284; 1285; 1469; 1470; 1471; 1519; 1520; 1521; 1524; 2065; 2067 and 2089 are present in three copies, SEQ ID NO 1194 is present in 4 copies and SEQ ID NOs 315 and 1162 are present in 6 copies, or
    • the polynucleotide probes contained in said 1228 polynucleotide probe sets being represented in the first 1228 lines of the Table 7, or
    • the nucleic acid sequence of the polynucleotide probes contained in said 1640 polynucleotide probe sets being represented in Table 7.
The invention also relates to
    • a micro-array comprising the library of nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • a multiplicity of polynucleotide probe sets chosen among the group consisting in:
      • a multiplicity of 1228 polynucleotide probe sets comprising nucleic acid sequences chosen among the group consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • a multiplicity of 200 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • a multiplicity of 150 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, or
    • a multiplicity of 100 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, and in particular consisting in SEQ ID NO 120, SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 154, SEQ ID NO 155, SEQ ID NO 156, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 166, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 174, SEQ ID NO 175, SEQ ID NO 176, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 328, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331, SEQ ID NO 331, SEQ ID NO 332, SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 337, SEQ ID NO 338, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 349, SEQ ID NO 350, SEQ ID NO 351, SEQ ID NO 352, SEQ ID NO 353, SEQ ID NO 354, SEQ ID NO 355, SEQ ID NO 356, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 363, SEQ ID NO 364, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 369, SEQ ID NO 371, SEQ ID NO 376, SEQ ID NO 378, SEQ ID NO 379, SEQ ID NO 380, SEQ ID NO 381, SEQ ID NO 555, SEQ ID NO 556, SEQ ID NO 557, SEQ ID NO 558, SEQ ID NO 560, SEQ ID NO 561, SEQ ID NO 562, SEQ ID NO 566, SEQ ID NO 567, SEQ ID NO 788, SEQ ID NO 789, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 800, SEQ ID NO 801, SEQ ID NO 802, SEQ ID NO 821, SEQ ID NO 822, SEQ ID NO 823, SEQ ID NO 969, SEQ ID NO 971, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1056, SEQ ID NO 1057, SEQ ID NO 1058, SEQ ID NO 1075, SEQ ID NO 1076, SEQ ID NO 1077, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1087, SEQ ID NO 1088, SEQ ID NO 1089, SEQ ID NO 1103, SEQ ID NO 1104, SEQ ID NO 1105, SEQ ID NO 1114, SEQ ID NO 1115, SEQ ID NO 1116, SEQ ID NO 1123, SEQ ID NO 1124, SEQ ID NO 1125, SEQ ID NO 1129, SEQ ID NO 1130, SEQ ID NO 1131, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1142, SEQ ID NO 1143, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1163, SEQ ID NO 1163, SEQ ID NO 1164, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1172, SEQ ID NO 1172, SEQ ID NO 1180, SEQ ID NO 1181, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1187, SEQ ID NO 1188, SEQ ID NO 1189, SEQ ID NO 1189, SEQ ID NO 1190, SEQ ID NO 1191, SEQ ID NO 1192, SEQ ID NO 1193, SEQ ID NO 1194, SEQ ID NO 1195, SEQ ID NO 1196, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1201, SEQ ID NO 1202, SEQ ID NO 1203, SEQ ID NO 1207, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1509, SEQ ID NO 1510, SEQ ID NO 1511, SEQ ID NO 1519, SEQ ID NO 1520, SEQ ID NO 1520, SEQ ID NO 1521, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1524, SEQ ID NO 1528, SEQ ID NO 1529, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 1561, SEQ ID NO 1562, SEQ ID NO 1682, SEQ ID NO 1683, SEQ ID NO 1684, SEQ ID NO 1776, SEQ ID NO 1777, SEQ ID NO 1778, SEQ ID NO 2023, SEQ ID NO 2024, SEQ ID NO 2025, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2173, SEQ ID NO 2174, SEQ ID NO 2175, SEQ ID NO 2176, SEQ ID NO 2177, SEQ ID NO 2178, SEQ ID NO 2179, SEQ ID NO 2181, SEQ ID NO 2762, SEQ ID NO 2763, SEQ ID NO 2764, SEQ ID NO 2860, SEQ ID NO 2861, SEQ ID NO 2862, SEQ ID NO 2883, SEQ ID NO 2884 and SEQ ID NO 2885, or
    • a multiplicity of 50 polynucleotide probe sets comprising nucleic acid sequences consisting in SEQ ID NO 1 to SEQ ID NO 2938, and in particular consisting in SEQ ID NO 138, SEQ ID NO 140, SEQ ID NO 157, SEQ ID NO 159, SEQ ID NO 167, SEQ ID NO 168, SEQ ID NO 169, SEQ ID NO 171, SEQ ID NO 173, SEQ ID NO 177, SEQ ID NO 312, SEQ ID NO 314, SEQ ID NO 315, SEQ ID NO 317, SEQ ID NO 324, SEQ ID NO 326, SEQ ID NO 327, SEQ ID NO 329, SEQ ID NO 330, SEQ ID NO 331SEQ ID NO 333, SEQ ID NO 335, SEQ ID NO 336, SEQ ID NO 339, SEQ ID NO 341, SEQ ID NO 345, SEQ ID NO 347, SEQ ID NO 353, SEQ ID NO 360, SEQ ID NO 361, SEQ ID NO 364, SEQ ID NO 366, SEQ ID NO 367, SEQ ID NO 369, SEQ ID NO 790, SEQ ID NO 792, SEQ ID NO 793, SEQ ID NO 795, SEQ ID NO 969, SEQ ID NO 972, SEQ ID NO 981, SEQ ID NO 1081, SEQ ID NO 1083, SEQ ID NO 1129, SEQ ID NO 1140, SEQ ID NO 1141, SEQ ID NO 1151, SEQ ID NO 1158, SEQ ID NO 1159, SEQ ID NO 1162, SEQ ID NO 1165, SEQ ID NO 1166, SEQ ID NO 1167, SEQ ID NO 1169, SEQ ID NO 1170, SEQ ID NO 1171, SEQ ID NO 1185, SEQ ID NO 1186, SEQ ID NO 1194, SEQ ID NO 1198, SEQ ID NO 1200, SEQ ID NO 1203, SEQ ID NO 1262, SEQ ID NO 1264, SEQ ID NO 1267, SEQ ID NO 1269, SEQ ID NO 1520, SEQ ID NO 1522, SEQ ID NO 1523, SEQ ID NO 1524, SEQ ID NO 1534, SEQ ID NO 1536, SEQ ID NO 1544, SEQ ID NO 1546, SEQ ID NO 1551, SEQ ID NO 1553, SEQ ID NO 1554, SEQ ID NO 1556, SEQ ID NO 1557, SEQ ID NO 2026, SEQ ID NO 2028, SEQ ID NO 2179 and SEQ ID NO 2181.
Preferably in the kit of the invention, the micro-array comprises 1228 polynucleotide probe sets that represent the best multiplicity of polynucleotide probe sets to characterize efficiently the benign or malignant status of the breast tumor of a subject.
Optionally, the kit of the invention may contain protocol and molecules to label nucleic acid molecules used to be contacted with the micro-array. Also, the kit of the invention may contain protocol and material for the extraction and purification of the nucleic acid molecules from the biological sample of a subject.
The contain of the kit is not limited to the described materials and protocols described above, and may contain any other material or procedures that can help a skilled man in the art to use the kit of the invention.
FIGS. 1 TO 6 ILLUSTRATE THE INVENTION
FIG. 1A represents a gene containing 3 exons, and its variants that lack at least one exon. T represents a Target region. The “bar code” associated to the presence or absence of a target region is indicated: 1=present; 0=absent.
FIG. 1B represents a gene containing 3 exons, and its variant that lacks one exon. T represents a Target region. The “bar code” associated to the presence or absence of a target region is indicated: 1=present; 0=absent.
FIG. 2 represents the notions of multiplicity, pool, probe set and probes of the invention.
FIG. 3A to 3G represent the gene and its variant when they exist and the corresponding target region.
FIG. 3A represents a gene having no variant and having one target region.
FIG. 3B represents a gene having no variant and having two target regions.
FIG. 3C represents a gene having one variant and having one target region.
FIG. 3D represents a gene having one variant and having two target regions.
FIG. 3E represents a gene having two variants and having two target regions.
FIG. 3F represents a gene having two variants and having three target regions.
FIG. 3G represents a gene having two variants and having three target regions, one of its target regions being in a configuration different in variant and gene.
FIG. 4 represents Heatmap of the 1656 exon-probes that present a more than two fold higher intensity in malignant condition. The FIG. 4 reports the intensities of exon-probes that present more than a two-fold higher intensity in malignant tumors. Each column represents a sample, and each raw represent an exon-probe.
FIG. 5 represents the correlation of each specimen with the average benign and malignant profiles. Each tumor is classified according to its correlation with the average expressions of the probes in the benign and malignant group respectively during one leave-one-out-step. The bisecting line defines a region of benign prediction (bottom right triangle) and malignant prediction (upper left triangle). Tumors from the benign group are depicted in black, and those from the malignant group, in grey. Any misclassifications correspond to benign samples located in the malignant prediction area and vice versa. Training set included 94 samples (benign tumor, n=24, malignant tumor, n=70).
FIG. 6 represents the correlation of each specimen in the validation set with the average benign and malignant profiles of the preferred 1,228 signature polynucleotide probe sets obtained on the patients in the training set. Validation set included 71 samples (benign tumor, n=21, malignant tumor, n=50). Each tumor is classified according to its correlation with the average expressions of the probes in the benign and malignant profiles. The bisecting line defines a region of benign prediction (bottom right triangle) and malignant prediction (upper left triangle). Tumors from the benign group are depicted in black, and those from the malignant group, in grey. Any misclassifications correspond to benign samples located in the malignant prediction area and vice versa.
The following examples illustrate the invention, but the invention is not limited to these examples.
EXAMPLE I Differentially Expressed Genes and Exons Between Malignant and Benign Breast Diseases
56652 probes (8%) presented a different intensity between malignant and benign conditions (adjusted p value<0.05). Of these, 37858 were exon-probes (B, T, and F) and 18794 were junction-probes (C, D, E). Of the 37858 exon-probes (B, T, F), 17441 were higher in malignant as opposed to benign diseases. The 17441 exon-probes (B, T, F) that were found higher in malignant condition referred to 12091 exons and 3391 genes. Of the 17441 exon-probes increased in malignant tumors, 1656 presented more than a two fold increased intensity in malignant conditions as compared to benign tumors. Heatmap of intensities for these 1656 probes is reported in FIG. 4. These 1656 probe sets referred to 1178 exons and 363 genes.
The level of gene expression was then determined as reported in patients and methods section. Among the 11921 filtered genes, 3733 were differentially expressed between cancer and benign conditions (adjusted p value <0.05). This accounts for 7% of the overall genes included in the array and 31% of the filtered genes. Of these, 1984 were overexpressed in malignant condition. Several of these genes are currently being targeted in therapeutics including TOP2A, VEGFA, AURKA, PARP1, RAS. Seventy-two genes presented more than a two fold increase of the mean value in breast cancer. As expected, a high proportion of these 72 highly overexpressed genes related to cell cycle activation and mitosis, including cyclins (CCNA2, CCNE2, CCNB2), cell division cycle family (CDC2, CKS1B, CKS2, NUF2), kinesin family members (KIF23, NDC80, KIF4A, KIF18A, MKLP2, KIF14) and centromere proteins (CENPF, CENPE). FIG. 3 reports the dot-plots for gene expression of the top 10 overexpressed genes. Two (PTTG1, NET1) of the 10 most overexpressed genes were considered as potential new therapeutic targets given their oncogenic properties. Pathways analyses using BioCarta database identified 7 pathways that presented an enrichment of genes differentially expressed in one or the other condition. Interestingly, genes involved in spliceosome assembly were significantly enriched in malignant condition (LS permutations, p=0.001, KS permutations, p=0.002), suggesting an activation of this phenomenon in breast cancer.
Finally, the inventors identified 2675 exons (adjusted p value <0.05) overexpressed in malignant condition who were not located within the 1984 filtered genes whose geometric mean values differ between cancer and benign lesions. These 2675 exon-probes were located in 1559 genes. The splice index for the 2675 exon is reported in supplementary table 4. Numbers of these over-expressed exons located within unchanged genes have potential oncogenic properties. As illustration, probe sets for exon 9 casein kinase 1 delta (CSNK1D), exon 5-6 retinoblastoma binding protein 9 (RBBP9) and exon 21-22 Erbb2 interacting protein (ERBB2IP/LAP2) presented a 1.67 (adjusted p=0.005), 1.45 (adjusted p=0.006) and 1.6 (adjusted p=0.0005) fold increased intensity in malignant as compared to benign tumors. At the opposite, the geo mean ratio between cancer and benign tumors for gene expression levels were 1.09 (p=0.95), 1.04 (p=0.61) and 1.00 (p=0.96) for CSNK1D, RBBP9, ERBB2IP/LAP2 respectively. These findings suggest that a significant proportion of genes identified as unchanged may actually contain differentially expressed exons. These considerations suggest that analyses at exon level provide additional information to analyses at gene level, to decipher the transcriptional program of breast malignancy.
Based on the finding that breast cancer and benign tumors present widely different exonic profiles, the inventors developed a molecular classifier for breast cancer diagnosis on FNA samples.
EXAMPLE II Development of a Molecular Classifier for Breast Cancer Diagnosis
Patients et Methods.
Patients.
94 patients have been included in the present study. These patients referred at the Institut Gustave Roussy for a clinical or radiological breast lesion in 2006. FNA was performed in all of these patients to assess the diagnosis of the breast lesion. A breast adenocarcinoma was diagnosed in 70 patients, and a benign lesion was diagnosed in 24 patients. Breast cancer diagnosis was based on the identification of cancer cells on the CNB or surgical specimen. The diagnosis of benign lesion was based on the identification of non-malignant epithelial cells on CNB and the identification of non-malignant epithelial cells in FNA sample together with lack of radiological change after 3 or 6 months follow-up. Patient characteristics are reported in Table 2.
TABLE 2
Table 2: patient characteristics
Benign lesions Malignant lesions
(n = 24) (n = 70)
Median Age (range) 41 (16-74) 59 (30-92)
Median clinical size (range) 17 mm (7-35) 29 mm (7-110)
ACR classification
ACR3 14 (58%) 0
ACR4 9 (37%) 13 (19%)
ACR5 1 (5%) 56 (81%)
Not assessable 1
Palpable lesion
Yes 15 (65%) 53 (78%)
NO 8 (35%) 15 (22%)
Not assessable 1 2
Pathological tumor size (range) NA 28 mm (6-60)
pTNM Stage
Node negative disease 27 (45%)
Node positive disease NA 20 (33%)
Stage IV disease 1 (2%)
Preoperative medical treatment 12 (20%)
Not assessable 10
Tumor grade
Grade 1 17 (27%)
Grade 2 NA 24 (37%)
Grade 3 23 (36%)
Not Assessable 6
Estogen receptor expression
ER negative 17 (25%)
ER positive NA 50 (75%)
Not assessable 3
Progesteron receptor expression
PR negative 29 (43%)
PR positive NA 39 (57%)
Not assessable 3
Her2 status
Overexpression 13 (20%)
Not overexpressed NA 53 (80%)
Not assessable 4

Sample Processing and Hybridization
RNA was extracted using RNEasy kit (Qiagen) from FNA specimen. Total RNA quality and quantity were evaluated using the RNA 6000 Nano LabChip kit with the Agilent 2100 Bioanalyzer.
Sample amplification and labeling was performed using the WT-Ovation Pico RNA Amplification System and the FL-Ovation cDNA Biotin Module v2 (NuGen, Inc., part #'s 3300-60 and 4200-60) according to manufacturer's instructions.
Standard methods following recommendations of the manufacturer were used to hybridize the samples. A pan-genomic array has been designed to detect 138,636 splicing events. 20,649 genes are analyzed using this array. The overall number of probes included in this array was 6,079,562. The present study was focused on 703,680 Evidenced probes. Once hybridized, the arrays were washed and stained using the FS450-0001 Fluidics protocol prior to scanning using the Affymetrix GeneChip® Scanner 3000 7G. .DAT and .CEL images were visually inspected for anomalies and accurate grid placement. The .CEL files were imported into Partek® Genomics Suite and the data were processed using the Robust Multichip Average (RMA) background correction method followed by GC content background correction. Quantile normalization was performed across all arrays, and then data was Log2 transformed and mean probe summarization was performed.
Normalization
Data were processed using the RMA background correction method followed by guanine-cytosine content background correction. Quantile normalization was performed across all arrays, and then data was log2 transformed and mean probe summarization was performed.
Pre-filtering
Starting from the 703,680 Evidenced probes, the inventors filtered out probes whose expression varied little across the 94 patient training set as follows: first the inventors floored the expression values at 10 (i.e. all expression values lower than 10 were replaced by 10), and secondly they deleted a probe from the data set if the ratio of the maximum by minimum intensity across the 94-patient set was higher or equal to 5 and if the difference between the maximum and minimum intensity was higher or equal to 100. In total 176,832 probes were retained for analysis after the pre-filtering step.
Statistical Analysis
The point biserial correlation coefficient was calculated for each probe between probe expression and a binary indicator which value was defined by the status of the patient (the indicator took the value 0 in patients who had benign tissue and the value 1 in tissues from patients with tumors) (Kraemer H C: Biserial correlation, in Encyclopedia of Statistical Science, Vol 1. Edited by Kotz S, Read C B. New York, Wiley, 1982, pp 276-280). The probes with the highest absolute correlation are those which are the most likely correlated with the occurrence of a tumor. The inventors used the t-test to test whether the point biserial correlation values were significantly different from 0 (Kraemer HC: Biserial correlation, in Encyclopedia of Statistical Science, Vol 1. Edited by Kotz S, Read C B. New York, Wiley, 1982, pp 276-280). In order to take the multiple testing issues into account they used a very stringent cut-off for statistical significance: 10e-8 (1 out of 100 million).
In order to develop a prediction rule to classify tissues from new patients with unknown status (benign vs. malignant), the inventors chose the nearest centroid prediction rule, which has been intensively studied on data from several microarray studies (S. Michiels, S. Koscielny, C. Hill. Prediction of cancer outcome with microarrays: a multiple random validation strategy. Lancet 2005; 365:488-92). This prediction rule classifies new patients according to the Pearson correlation between the expression of their signature probes and the average profiles in the two categories (the average benign and malignant profiles are defined as the vector of the average expression values of the signature probes in patients with benign and malignant tissues of the 94 patient training set), the predicted category being the one with the highest Pearson correlation. The signature probes were defined as those probes for which the p-value of test of significance of the point biserial correlation coefficient with the benign vs. malignant status was below a particular threshold.
Leave-one-out cross-validation was used to estimate the prediction accuracy of the prediction rule. One sample is left out, and the remaining samples are used to build the prediction rule, which is then used to classify the left-out sample. The entire model-building process was repeated for each leave-one-out training set to provide unbiased estimates of the prediction accuracy (Ntzani E E, Ioannidis J P. Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment. Lancet 2003; 362: 1439-44; Simon R, Radmacher M D, Dobbin K, McShane L M. Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. J Natl Cancer Inst 2003; 95: 14-8): correlation coefficients were recalculated, ordered according to their absolute value, the signature probes defined and the nearest centroid prediction rule was constructed. Then, the inventors predicted the outcome of the one sample they left out in the first place based on the highest correlation coefficient it had with the average benign and the malignant profile from the 93 other samples. At the end of the leave-one-out cross-validation procedure, the inventors counted in how many cases the predictions were correct and in how many cases the predictions were incorrect.
The inventors repeated the above performance evaluation procedure based on leave-one-out cross-validation for different p-value thresholds for signature genes in order to find an optimal prediction rule yielding the lowest number of misclassified patients. They tried the following four p-values thresholds to define the signature genes: 10e-11, 10e-10, 10e-09 and 10e-8.
The inventors also provide subsets of 50, 100, 150 and 200 polynucleotide probe sets whose expression can be used to classify the benign and malignant status of tissues of new patients.
Results:
The inventors found 1,640 Evidenced polynucleotide probe sets that were significantly associated with malignancy at the stringent p-value cut-off of p<10e-8 (see Table 3). The polynucleotide probe sets with positive correlation are those which have increased expression in malignant tissues, those with negative correlation have increased expression in the benign tissues.
The inventors developed an optimal prediction rule based on the methodology explained above. The preferred p-value threshold for defining signature genes was p<10e-9. This p-value threshold corresponds to the first 1228 polynucleotide probe sets in Table 3 (with identifier no 1 to no 1228). When using leave-one-out cross-validation to estimated the prediction accuracy of the prediction rule with this particular threshold, they obtained 0 out of 24 patients (0%) with benign status that were misclassified and 0 out of 70 patients with malignant status that were misclassified (0%). This corresponds to a sensitivity of 100% and a specificity of 100%.
TABLE 3
Polynucleotides probe sets that harbor different values between malignant and benign tumors.
variant
No Probeset_ID correl abs_correl tstat pvalue Event_ID reference_representative_accession variant_representative_accession variant_representative_database nb
1 1756.022.2-C_at −0.91151 0.91150698 21.25746 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
2 1756.029.1-D_at −0.89254 0.89253605 18.98306 <1e−16 1756.029. NM_000109.2 BI551231.1 EST 1
3 1756.026.1-C_at −0.89221 0.8922081 18.94884 <1e−16 1756.026. NM_000109.2 M63075.1 mRNA 1
4 1756.022.4-T_at −0.87666 0.87666398 17.47788 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
5 1756.011.1-B_at −0.87581 0.87581182 17.40484 <1e−16 1756.011. NM_000109.2 AX114289.1 GENBANK_PATENT 1
6 1308.008.1-C_at −0.86492 0.86492412 16.52922 <1e−16 1308.008. NM_130778.1 BE148646.1 EST 1
7 1756.022.3-F_at −0.84937 0.84936983 15.43558 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
8 3861.020.1-D_at −0.84359 0.84358795 15.06806 <1e−16 3861.020. NM_000526.3 BM018298.1 EST 1
9 1756.011.1-F_at −0.83903 0.83903098 14.7913 <1e−16 1756.011. NM_000109.2 AX114289.1 GENBANK_PATENT 1
10 4629.007.1-F_at −0.83653 0.83653075 14.64397 <1e−16 4629.007. NM_022844.1 AY520817.1 mRNA 16
11 1756.022.4-B_at −0.83558 0.83557952 14.58872 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
12 1756.024.1-F_at −0.83305 0.83304555 14.44365 <1e−16 1756.024. NM_000109.2 CD299688.1 EST 1
13 3861.019.1-T_at −0.83092 0.83091678 14.32409 <1e−16 3861.019. NM_000526.3 BO359236.1 EST 1
14 1756.026.1-T_at −0.83005 0.83004684 14.27581 <1e−16 1756.026. NM_000109.2 M63075.1 mRNA 1
15 1756.022.1-B_at −0.82986 0.8298586 14.26541 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
16 3861.001.1-T_at −0.82888 0.82888471 14.21185 <1e−16 3861.001. NM_000526.3 BG677893.1 EST 1
17 1308.008.1-T_at −0.82731 0.82731458 14.12635 <1e−16 1308.008. NM_130778.1 BE148646.1 EST 1
18 4629.020.1-C_at −0.82454 0.82453945 13.97781 <1e−16 4629.020. NM_022844.1 BI819760.1 EST 1
19 1756.027.1-T_at −0.82281 0.82280868 13.88676 <1e−16 1756.027. NM_000109.2 S60971.1 mRNA 1
20 3861.013.1-T_at −0.82153 0.82153279 13.82042 <1e−16 3861.013. NM_000526.3 BM563823.1 EST 1
21 4629.020.1-F_at −0.8194 0.81940128 13.71099 <1e−16 4629.020. NM_022844.1 BI819760.1 EST 1
22 3861.001.1-B_at −0.81782 0.8178189 13.63089 <1e−16 3861.001. NM_000526.3 BG677893.1 EST 1
23 1756.022.4-F_at −0.81687 0.81686612 13.5831 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
24 1756.026.1-F_at −0.81627 0.81626518 13.55314 <1e−16 1756.026. NM_000109.2 M63075.1 mRNA 1
25 1756.022.2-T_at −0.81571 0.815705 13.52532 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
26 1756.022.2-F_at −0.81498 0.8149825 13.48962 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
27 3861.022.1-B_at −0.81494 0.81494272 13.48766 <1e−16 3861.022. NM_000526.3 BI085500.1 EST 1
28 3868.004.1-D_at −0.81412 0.81412336 13.4474 <1e−16 3868.004. NM_005557.2 BM045170.1 EST 1
29 4629.015.1-C_at −0.81348 0.81347687 13.41581 <1e−16 4629.015. NM_022844.1 DB284318.1 EST 1
30 6422.002.1-E_at −0.81346 0.81346311 13.41514 <1e−16 6422.002. NM_003012.3 AX565729.1 GENBANK_PATENT 3
31 3861.001.1-D_at −0.81115 0.81115184 13.30339 <1e−16 3861.001. NM_000526.3 BG677893.1 EST 1
32 1756.022.1-F_at −0.81112 0.81111566 13.30165 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
33 1308.003.1-T_at −0.80635 0.80635142 13.07706 <1e−16 1308.003. NM_130778.1 NM_000494.2 REFSEQ 19
34 3868.005.1-B_at −0.8061 0.80610095 13.06545 <1e−16 3868.005. NM_005557.2 BG682632.1 EST 1
35 1308.007.1-F_at −0.8044 0.80440011 12.98719 <1e−16 1308.007. NM_130778.1 BF916393.1 EST 1
36 1308.009.1-F_at −0.8039 0.80390038 12.96437 <1e−16 1308.009. NM_130778.1 DA425187.1 EST 1
37 3861.007.1-E_at −0.8038 0.80380368 12.95997 <1e−16 3861.007. NM_000526.3 BG682207.1 EST 11
38 4629.016.1-D_at −0.80378 0.80377953 12.95887 <1e−16 4629.016. NM_022844.1 DB289769.1 EST 1
39 3084.007.1-F_at −0.80131 0.80130924 12.84728 <1e−16 3084.007. NM_013957.1 CN603653.1 EST 3
40 3861.007.1-F_at −0.79968 0.79968463 12.77489 <1e−16 3861.007. NM_000526.3 BG682207.1 EST 11
41 26289.003.1-E_at −0.79508 0.7950811 12.57397 <1e−16 26289.003 NM_174858.1 AK090967.1 mRNA 3
42 1756.028.1-T_at −0.79389 0.79388677 12.52282 <1e−16 1756.028. NM_000109.2 CQ733377.1 GENBANK_PATENT 1
43 4629.021.1-E_at −0.7935 0.79350334 12.50648 <1e−16 4629.021. NM_022844.1 CQ717811.1 GENBANK_PATENT 1
44 4629.020.1-D_at −0.78948 0.78947575 12.33726 <1e−16 4629.020. NM_022844.1 BI819760.1 EST 1
45 5764.001.1-F_at −0.78733 0.78733221 12.24894 <1e−16 5764.001. NM_002825.5 AX135902.1 GENBANK_PATENT 3
46 3815.002.3-F_at −0.78506 0.78505901 12.15655 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
47 3852.020.1-T_at −0.78181 0.78181405 12.02688 <1e−16 3852.020. NM_000424.2 DA764792.1 EST 1
48 4629.007.1-E_at −0.78063 0.78063131 11.98024 <1e−16 4629.007. NM_022844.1 AY520817.1 mRNA 16
49 128553.003.1-F −0.78062 0.78061872 11.97975 <1e−16 128553.00 NM_173485.2 BP394387.1 EST 1
50 26289.003.1-F_at −0.78004 0.78004 11.95705 <1e−16 26289.003 NM_174858.1 AK090967.1 mRNA 3
51 3815.002.2-F_at −0.77826 0.77825678 11.88761 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
52 1756.029.1-B_at −0.77795 0.77795132 11.87578 <1e−16 1756.029. NM_000109.2 BI551231.1 EST 1
53 4629.005.1-E_at −0.7779 0.77790413 11.87396 <1e−16 4629.005. NM_022844.1 CB963138.1 EST 3
54 4629.010.1-B_at −0.77786 0.77786129 11.8723 <1e−16 4629.010. NM_022844.1 AI285326.1 EST 1
55 6422.001.1-T_at −0.77686 0.77685589 11.83356 <1e−16 6422.001. NM_003012.3 CQ850220.1 GENBANK_PATENT 2
56 5764.001.1-E_at −0.77561 0.77560627 11.78573 <1e−16 5764.001. NM_002825.5 AX135902.1 GENBANK_PATENT 3
57 3861.008.1-F_at −0.77548 0.77547795 11.78084 <1e−16 3861.008. NM_000526.3 BE184532.1 EST 1
58 1756.030.2-T_at −0.77479 0.77478755 11.75458 <1e−16 1756.030. NM_000109.2 BM929495.1 EST 1
59 3084.009.1-B_at −0.77277 0.77277347 11.67858 <1e−16 3084.009. NM_013957.1 U02327.1 mRNA 2
60 26289.002.1-T_at −0.77207 0.7720739 11.65239 <1e−16 26289.002 NM_174858.1 BF966377.1 EST 1
61 1756.022.5-B_at −0.77137 0.77136743 11.62604 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
62 4629.007.1-D_at −0.77091 0.77091122 11.60908 <1e−16 4629.007. NM_022844.1 AY520817.1 mRNA 16
63 23336.001.1-C_at −0.76979 0.76978838 11.56754 <1e−16 23336.001 NM_145728.1 AJ697971.1 mRNA 1
64 1308.003.1-D_at −0.76831 0.7683088 11.5132 <1e−16 1308.003. NM_130778.1 NM_000494.2 REFSEQ 19
65 1756.022.3-T_at −0.76731 0.76730759 11.47668 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
66 3861.020.1-T_at −0.76715 0.76714705 11.47084 <1e−16 3861.020. NM_000526.3 BM018298.1 EST 1
67 3861.022.1-C_at −0.76448 0.76448457 11.37481 <1e−16 3861.022. NM_000526.3 BI085500.1 EST 1
68 3852.012.2-B_at −0.76294 0.76294046 11.31975 <1e−16 3852.012. NM_000424.2 CQ733668.1 GENBANK_PATENT 1
69 26289.012.1-E_at −0.76192 0.76191947 11.28361 <1e−16 26289.012 NM_174858.1 BG189938.1 EST 1
70 23336.003.1-T_at −0.76122 0.76122392 11.2591 <1e−16 23336.003 NM_145728.1 CQ723645.1 GENBANK_PATENT 1
71 26289.007.1-B_at −0.76082 0.76081931 11.24488 <1e−16 26289.007 NM_174858.1 DA259560.1 EST 1
72 84417.001.1-T_at −0.76076 0.76075848 11.24275 <1e−16 84417.001 NM_032411.1 BI561114.1 EST 1
73 3861.018.1-D_at −0.7605 0.76050387 11.23382 <1e−16 3861.018. NM_000526.3 BM019687.1 EST 1
74 3852.004.1-B_at −0.76039 0.76038766 11.22975 <1e−16 3852.004. NM_000424.2 BE715131.1 EST 1
75 90865.006.1-B_at −0.76035 0.76035315 11.22855 <1e−16 90865.006 NM_033439.2 AV707946.1 EST 1
76 4629.021.1-F_at −0.76012 0.7601167 11.22027 <1e−16 4629.021. NM_022844.1 CQ717811.1 GENBANK_PATENT 1
77 3861.018.1-T_at −0.76002 0.76001693 11.21679 <1e−16 3861.018. NM_000526.3 BM019687.1 EST 1
78 1756.022.1-T_at −0.75998 0.75998388 11.21563 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
79 1264.003.1-B_at −0.75956 0.75955538 11.20068 <1e−16 1264.003. NM_001299.4 CV811526.1 EST 1
80 26289.010.1-E_at −0.7591 0.75909546 11.18467 <1e−16 26289.010 NM_174858.1 AX988359.1 GENBANK_PATENT 1
81 3861.001.1-F_at −0.75842 0.75842235 11.16131 <1e−16 3861.001. NM_000526.3 BG677893.1 EST 1
82 1908.002.1-T_at −0.75841 0.75841175 11.16094 <1e−16 1908.002. NM_207032.1 NM_207033.1 REFSEQ 8
83 4629.007.1-C_at −0.75757 0.75757437 11.132 <1e−16 4629.007. NM_022844.1 AY520817.1 mRNA 16
84 1756.022.5-T_at −0.75733 0.75732729 11.12348 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
85 3815.002.4-B_at −0.75611 0.75610941 11.08167 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
86 1756.022.2-B_at −0.75476 0.75476064 11.03568 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
87 1756.027.1-B_at −0.75441 0.75441365 11.0239 <1e−16 1756.027. NM_000109.2 S60971.1 mRNA 1
88 3852.008.2-T_at −0.75435 0.75434944 11.02172 <1e−16 3852.008. NM_000424.2 BG675837.1 EST 1
89 6422.001.1-E_at −0.75383 0.75383168 11.00419 <1e−16 6422.001. NM_003012.3 CQ850220.1 GENBANK_PATENT 2
90 3861.022.1-F_at −0.75247 0.75247162 10.95837 <1e−16 3861.022. NM_000526.3 BI085500.1 EST 1
91 4915.011.1-D_at −0.75125 0.75124983 10.91748 <1e−16 4915.011. NM_006180.3 CQ723929.1 GENBANK_PATENT 1
92 5288.001.1-F_at −0.75114 0.75113721 10.91373 <1e−16 5288.001. NM_004570.2 CQ720591.1 GENBANK_PATENT 1
93 3861.007.1-T_at −0.75024 0.75024416 10.88402 <1e−16 3861.007. NM_000526.3 BG682207.1 EST 11
94 3852.006.1-C_at −0.74966 0.74965968 10.86465 <1e−16 3852.006. NM_000424.2 BG679014.1 EST 1
95 9413.003.1-T_at −0.74954 0.74953975 10.86069 <1e−16 9413.003. NM_004816.2 BX641153.1 mRNA 10
96 3861.020.1-C_at −0.74922 0.74922185 10.85018 <1e−16 3861.020. NM_000526.3 BM018298.1 EST 1
97 1308.008.1-D_at −0.7468 0.746803 10.77082 <1e−16 1308.008. NM_130778.1 BE148646.1 EST 1
98 23336.001.1-T_at −0.74666 0.74665951 10.76614 <1e−16 23336.001 NM_145728.1 AJ697971.1 mRNA 1
99 3815.001.1-F_at −0.74657 0.74656536 10.76307 <1e−16 3815.001. NM_000222.1 CS237377.1 GENBANK_PATENT 1
100 1756.022.5-F_at −0.74654 0.74654247 10.76233 <1e−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
101 79937.001.1-T_at −0.74608 0.74607796 10.74722 <1e−16 79937.001 NM_033655.2 AF333769.2 mRNA 1
102 4915.012.1-E_at −0.74575 0.74575052 10.73659 <1e−16 4915.012. NM_006180.3 CD103051.1 EST 1
103 3861.022.1-T_at −0.74356 0.74356005 10.66593 <1e−16 3861.022. NM_000526.3 BI085500.1 EST 1
104 26289.005.1-T_at −0.74355 0.74354601 10.66548 <1e−16 26289.005 NM_174858.1 BI546738.1 EST 1
105 3815.002.3-B_at −0.74306 0.74306109 10.64994 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
106 4311.009.1-F_at −0.74287 0.74287019 10.64383 <1e−16 4311.009. NM_000902.2 A30431.1 GENBANK_PATENT 1
107 26289.006.1-T_at −0.74283 0.74282989 10.64255 <1e−16 26289.006 NM_174858.1 CN356131.1 EST 1
108 5288.003.1-F_at −0.74231 0.74231399 10.62608 <1e−16 5288.003. NM_004570.2 CQ721655.1 GENBANK_PATENT 1
109 4629.020.1-B_at −0.7423 0.74230371 10.62575 <1e−16 4629.020. NM_022844.1 BI819760.1 EST 1
110 26289.007.1-D_at −0.74169 0.74168883 10.60617 <1e−16 26289.007 NM_174858.1 DA259560.1 EST 1
111 3815.002.1-B_at −0.74167 0.74166962 10.60556 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
112 26289.004.1-T_at −0.74153 0.74153045 10.60114 <1e−16 26289.004 NM_174858.1 NM_012093.2 REFSEQ 7
113 79192.002.2-T_at −0.74131 0.74131399 10.59427 <1e−16 79192.002 NM_024337.3 CQ731489.1 GENBANK_PATENT 1
114 4638.006.1-D_at −0.74126 0.74125872 10.59252 <1e−16 4638.006. NM_053025.2 DR005817.1 EST 2
115 3084.008.1-F_at −0.74052 0.74051659 10.56902 <1e−16 3084.008. NM_013957.1 CQ733299.1 GENBANK_PATENT 1
116 4311.001.2-T_at −0.73955 0.73955496 10.5387 <1e−16 4311.001. NM_000902.2 CB988534.1 EST 1
117 3815.002.1-D_at −0.73931 0.73930643 10.53089 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
118 4629.020.1-T_at −0.73906 0.73905518 10.523 <1e−16 4629.020. NM_022844.1 BI819760.1 EST 1
119 1756.026.1-B_at −0.739 0.73899721 10.52119 <1e−16 1756.026. NM_000109.2 M63075.1 mRNA 1
120 3852.022.1-T_at −0.73857 0.73856714 10.50771 <1e−16 3852.022. NM_000424.2 BP226135.1 EST 1
121 4629.015.1-D_at −0.73849 0.73848689 10.5052 <1e−16 4629.015. NM_022844.1 DB284318.1 EST 1
122 26289.007.1-C_at −0.73826 0.73825579 10.49797 <1e−16 26289.007 NM_174858.1 DA259560.1 EST 1
123 23194.003.1-C_at −0.73638 0.73638084 10.43964 <1e−16 23194.003 NM_012304.3 BP290286.1 EST 1
124 3815.002.1-F_at −0.73534 0.73534271 10.40757 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
125 26289.007.1-T_at −0.7346 0.73459701 10.38463 <1e−16 26289.007 NM_174858.1 DA259560.1 EST 1
126 65983.009.1-B_at −0.73458 0.73457702 10.38401 <1e−16 65983.009 NM_023927.1 CQ413222.1 GENBANK_PATENT 2
127 23336.001.1-F_at −0.73393 0.73392505 10.36403 <1e−16 23336.001 NM_145728.1 AJ697971.1 mRNA 1
128 1410.007.2-B_at −0.73346 0.73346173 10.34986 <1e−16 1410.007. NM_001885.1 BI548180.1 EST 1
129 1756.029.1-F_at −0.73299 0.73298982 10.33546 <1e−16 1756.029. NM_000109.2 BI551231.1 EST 1
130 7373.003.6-C_at −0.73258 0.73257952 10.32297 <1e−16 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
131 10010.002.1-E_at −0.7322 0.73219822 10.31139 <1e−16 10010.002 NM_004180.2 CF242863.1 EST 1
132 59.026.1-B_at −0.73215 0.73215036 10.30993 <1e−16 59.026.1 — — — —
133 4915.011.1-F_at −0.73192 0.73191927 10.30292 <1e−16 4915.011. NM_006180.3 CQ723929.1 GENBANK_PATENT 1
134 3872.007.1-D_at −0.73192 0.73191502 10.30279 <1e−16 3872.007. NM_000422.1 BU155457.1 EST 1
135 26289.002.1-D_at −0.73171 0.73171045 10.2966 <1e−16 26289.002 NM_174858.1 BF966377.1 EST 1
136 84668.002.1-C_at −0.73162 0.73162167 10.29391 <1e−16 84668.002 NM_032581.2 AL833296.1 mRNA 20
137 1756.002.2-T_at −0.73157 0.73156873 10.2923 <1e−16 1756.002. NM_000109.2 NM_004016.1 REFSEQ 30
138 57447.033.1-C_at −0.73085 0.73084864 10.27055 <1e−16 57447.033 NM_201535.1 DA135222.1 EST 1
139 26289.009.1-E_at −0.7304 0.73039812 10.25697 <1e−16 26289.009 NM_174858.1 AA393277.1 EST 1
140 3872.006.1-F_at −0.73024 0.73023988 10.25221 <1e−16 3872.006. NM_000422.1 BM017443.1 EST 1
141 3861.022.1-D_at −0.72983 0.72982952 10.23988 <1e−16 3861.022. NM_000526.3 BI085500.1 EST 1
142 3861.020.1-B_at −0.72921 0.72920518 10.22116 <1e−16 3861.020. NM_000526.3 BM018298.1 EST 1
143 667.021.1-B_at −0.72908 0.72907922 10.21739 <1e−16 667.021.1 NM_183380.1 DB134537.1 EST 1
144 57447.027.1-F_at −0.72812 0.72812186 10.18881 <1e−16 57447.027 NM_201535.1 BM810623.1 EST 9
145 56477.001.1-D_at −0.72775 0.72774687 10.17766 <1e−16 56477.001 NM_148672.1 NM_019846.3 REFSEQ 13
146 26289.008.1-F_at −0.72745 0.72744814 10.16878 <1e−16 26289.008 NM_174858.1 AV721097.1 EST 1
147 59.024.2-D_at −0.72739 0.72738851 10.16701 <1e−16 59.024.2 — — — —
148 4629.005.1-T_at −0.72738 0.7273826 10.16683 <1e−16 4629.005. NM_022844.1 CB963138.1 EST 3
149 3815.002.1-T_at −0.72727 0.72727235 10.16356 <1e−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
150 23336.001.1-B_at −0.72692 0.7269191 10.15309 <1e−16 23336.001 NM_145728.1 AJ697971.1 mRNA 1
151 3084.004.2-F_at −0.72617 0.72616697 10.13085   1E−16 3084.004. NM_013957.1 NM_013964.1 REFSEQ 5
152 27122.014.2-T_at −0.72585 0.72585166 10.12156   1E−16 27122.014 NM_013253.4 DA180412.1 EST 1
153 26289.008.1-C_at −0.72537 0.72537026 10.10738   1E−16 26289.008 NM_174858.1 AV721097.1 EST 1
154 286887.003.2-B −0.72458 0.72457637 10.08408   1E−16 286887.00 NM_173086.2 BG876719.1 EST 1
155 4629.005.1-F_at −0.72437 0.72437411 10.07816   1E−16 4629.005. NM_022844.1 CB963138.1 EST 3
156 3872.009.1-T_at −0.72329 0.72328551 10.04637   1E−16 3872.009. NM_000422.1 BX647923.1 mRNA 91
157 59.014.2-D_at −0.72287 0.72287431 10.0344   1E−16 59.014.2 NM_001613.1 CB962422.1 EST 1
158 403340.001.2-B −0.72269 0.72269253 10.02912   1E−16 403340.00 NM_203481.1 DA145754.1 EST 1
159 3852.014.1-F_at −0.72194 0.72194027 10.0073   1E−16 3852.014. NM_000424.2 BF826002.1 EST 1
160 27122.001.1-T_at −0.72089 0.72088962 9.976959   1E−16 27122.001 NM_013253.4 BP290952.1 EST 1
161 3815.002.3-T_at −0.72077 0.72076825 9.973463   1E−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
162 3852.008.1-E_at −0.72074 0.72073551 9.97252   1E−16 3852.008. NM_000424.2 BG675837.1 EST 1
163 26289.012.1-T_at −0.72072 0.72072375 9.972181   1E−16 26289.012 NM_174858.1 BG189938.1 EST 1
164 26289.007.1-F_at −0.72026 0.72026202 9.958901   1E−16 26289.007 NM_174858.1 DA259560.1 EST 1
165 4638.006.1-T_at −0.72019 0.72019094 9.956859   1E−16 4638.006. NM_053025.2 DR005817.1 EST 2
166 8626.005.1-B_at −0.71997 0.71997497 9.950658   1E−16 8626.005. NM_003722.3 AB042841.1 mRNA 1
167 3815.002.4-T_at −0.71955 0.71955195 9.938531   1E−16 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
168 84668.004.1-F_at −0.71918 0.71917508 9.927746   1E−16 84668.004 NM_032581.2 AL597549.1 EST 1
169 3872.007.1-F_at −0.71916 0.71915759 9.927246   1E−16 3872.007. NM_000422.1 BU155457.1 EST 1
170 57447.031.1-E_at −0.7189 0.71889801 9.919829   2E−16 57447.031 NM_201535.1 AI272253.1 EST 1
171 3084.012.3-T_at −0.71856 0.71855665 9.910088   2E−16 3084.012. NM_013957.1 U02325.1 mRNA 1
172 3852.005.1-T_at −0.71827 0.71827136 9.901958   2E−16 3852.005. NM_000424.2 R47851.1 EST 1
173 84417.001.2-T_at −0.71816 0.71816117 9.898821   2E−16 84417.001 NM_032411.1 BI561114.1 EST 1
174 3866.003.2-T_at −0.71746 0.71745931 9.878874   2E−16 3866.003. NM_002275.2 AK090604.1 mRNA 22
175 3866.008.1-C_at −0.71716 0.71715783 9.870325   2E−16 3866.008. NM_002275.2 BI771363.1 EST 1
176 3852.009.1-F_at −0.71671 0.71671024 9.857654   2E−16 3852.009. NM_000424.2 BQ378037.1 EST 1
177 59.015.1-B_at −0.71663 0.7166277 9.85532   2E−16 59.015.1 NM_001613.1 BP372009.1 EST 1
178 79937.002.1-F_at −0.71652 0.71651832 9.852229   2E−16 79937.002 NM_033655.2 AB051501.2 mRNA 9
179 7153.002.6-F_at 0.716462 0.71646227 9.850645   2E−16 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
180 4281.010.1-B_at −0.71619 0.71619361 9.84306   2E−16 4281.010. NM_033290.1 AY540016.1 mRNA 1
181 59.008.1-B_at −0.71578 0.7157817 9.831448   2E−16 59.008.1 NM_001613.1 BP373197.1 EST 1
182 1264.007.1-T_at −0.71577 0.71576716 9.831038   2E−16 1264.007. NM_001299.4 CX761868.1 EST 1
183 3868.004.1-T_at −0.7156 0.71560057 9.826348   2E−16 3868.004. NM_005557.2 BM045170.1 EST 1
184 3084.002.1-F_at −0.71513 0.71512815 9.813066   3E−16 3084.002. NM_013957.1 CN603657.1 EST 1
185 5137.004.2-T_at −0.71508 0.71508204 9.811771   3E−16 5137.004. NM_005020.1 BP222698.1 EST 1
186 4629.022.1-T_at −0.71428 0.71427853 9.789249   3E−16 4629.022. NM_022844.1 AX898971.1 GENBANK_PATENT 1
187 4915.011.1-T_at −0.71337 0.71336654 9.763782   3E−16 4915.011. NM_006180.3 CQ723929.1 GENBANK_PATENT 1
188 3852.013.1-E_at −0.71333 0.71332619 9.762657   3E−16 3852.013. NM_000424.2 BG682634.1 EST 1
189 59.012.2-T_at −0.71189 0.71189085 9.722787   4E−16 59.012.2 NM_001613.1 AL546033.3 EST 1
190 59.015.1-F_at −0.71184 0.71184354 9.721477   4E−16 59.015.1 NM_001613.1 BP372009.1 EST 1
191 4638.006.2-T_at −0.7112 0.71119714 9.703606   4E−16 4638.006. NM_053025.2 DR005817.1 EST 2
192 23336.002.1-B_at −0.7108 0.71079772 9.692588   6E−16 23336.002 NM_145728.1 NM_015286.4 REFSEQ 6
193 3868.005.1-C_at −0.70987 0.7098711 9.6671   6E−16 3868.005. NM_005557.2 BG682632.1 EST 1
194 3866.011.2-D_at −0.7087 0.70870117 9.635065   7E−16 3866.011. NM_002275.2 BQ218433.1 EST 1
195 56477.001.1-T_at −0.70868 0.70868235 9.634551   7E−16 56477.001 NM_148672.1 NM_019846.3 REFSEQ 13
196 3815.001.1-T_at −0.70825 0.70824726 9.622678   7E−16 3815.001. NM_000222.1 CS237377.1 GENBANK_PATENT 1
197 4311.001.1-T_at −0.70821 0.70820529 9.621535   7E−16 4311.001. NM_000902.2 CB988534.1 EST 1
198 1264.003.1-D_at −0.70785 0.70785219 9.611918   8E−16 1264.003. NM_001299.4 CV811526.1 EST 1
199 59.031.1-T_at −0.70756 0.70755684 9.603885   8E−16 59.031.1 NM_001613.1 BG197213.1 EST 19
200 57447.030.1-B_at −0.70751 0.70750665 9.60252   8E−16 57447.030 NM_201535.1 BM783465.1 EST 5
201 1410.003.2-B_at −0.70746 0.70745636 9.601154   8E−16 1410.003. NM_001885.1 AX899079.1 GENBANK_PATENT 1
202 3866.009.2-D_at −0.70722 0.70721526 9.594607   8E−16 3866.009. NM_002275.2 BI457146.1 EST 1
203 59.026.1-T_at −0.70717 0.70717265 9.59345   8E−16 59.026.1 — — — —
204 440421.001.1-T −0.70711 0.70711453 9.591873   8E−16 440421.00 XM_496202.2 XM_934894.1 REFSEQ 2
205 1756.022.4-D_at −0.70675 0.70675086 9.582014   9E−16 1756.022. NM_000109.2 CQ714747.1 GENBANK_PATENT 1
206 65983.009.1-D_at −0.7066 0.70660056 9.577944   9E−16 65983.009 NM_023927.1 CQ413222.1 GENBANK_PATENT 2
207 57447.041.1-T_at −0.70624 0.70624401 9.5683   9E−16 57447.041 NM_201535.1 DA295124.1 EST 1
208 3872.010.2-D_at −0.70603 0.7060339 9.562622   1E−15 3872.010. NM_000422.1 BM008795.1 EST 1
209 4629.006.2-T_at −0.70601 0.70600879 9.561944   1E−15 4629.006. NM_022844.1 DB079784.1 EST 1
210 3861.018.1-F_at −0.70592 0.70592127 9.559582   1E−15 3861.018. NM_000526.3 BM019687.1 EST 1
211 3815.002.2-T_at −0.70576 0.70576231 9.555292   1E−15 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
212 3866.012.2-D_at −0.70556 0.70555782 9.549778   1E−15 3866.012. NM_002275.2 BI772438.1 EST 1
213 57447.021.1-D_at −0.70548 0.70548085 9.547704   1E−15 57447.021 NM_201535.1 BQ954948.1 EST 28
214 59.015.1-T_at −0.70494 0.7049442 9.533261   1E−15 59.015.1 NM_001613.1 BP372009.1 EST 1
215 8626.007.1-F_at −0.70484 0.70483534 9.530336   1E−15 8626.007. NM_003722.3 BG698723.1 EST 1
216 5288.001.1-B_at −0.70452 0.70452172 9.521914   1E−15 5288.001. NM_004570.2 CQ720591.1 GENBANK_PATENT 1
217 72.001.1-B_at −0.70441 0.70440953 9.518904   1E−15 72.001.1 NM_001615.3 BP330025.1 EST 1
218 3866.006.2-D_at −0.70383 0.70382789 9.503322   1E−15 3866.006. NM_002275.2 BQ641523.1 EST 1
219 3852.004.1-T_at −0.70371 0.70371224 9.500228   1E−15 3852.004. NM_000424.2 BE715131.1 EST 1
220 4629.016.1-F_at −0.70364 0.70363752 9.49823   1E−15 4629.016. NM_022844.1 DB289769.1 EST 1
221 4629.007.1-T_at −0.70359 0.70358925 9.49694   1E−15 4629.007. NM_022844.1 AY520817.1 mRNA 16
222 65983.008.1-T_at −0.70354 0.70353523 9.495496   1E−15 65983.008 NM_023927.1 BI547735.1 EST 2
223 65983.013.1-F_at −0.70278 0.7027824 9.475409   1E−15 65983.013 NM_023927.1 AA610396.1 EST 1
224 3084.004.1-F_at −0.70205 0.70204717 9.455852   2E−15 3084.004. NM_013957.1 NM_013964.1 REFSEQ 5
225 27122.007.1-F_at −0.70181 0.70180898 9.449529   2E−15 27122.007 NM_013253.4 DA177251.1 EST 1
226 3866.008.1-D_at −0.70143 0.70142639 9.439386   2E−15 3866.008. NM_002275.2 BI771363.1 EST 1
227 26289.009.1-T_at −0.70109 0.70108634 9.430384   2E−15 26289.009 NM_174858.1 AA393277.1 EST 1
228 59.009.1-B_at −0.70065 0.7006532 9.418936   2E−15 59.009.1 NM_001613.1 CD299238.1 EST 1
229 4629.010.1-D_at −0.70044 0.70044198 9.413361   2E−15 4629.010. NM_022844.1 AI285326.1 EST 1
230 59.023.1-B_at −0.70011 0.70010609 9.404505   2E−15 59.023.1 NM_001613.1 DB248573.1 EST 1
231 26289.002.1-F_at −0.69973 0.6997339 9.394706   2E−15 26289.002 NM_174858.1 BF966377.1 EST 1
232 1908.001.1-T_at −0.69949 0.69948609 9.388191   2E−15 1908.001. NM_207032.1 BC008876.2 mRNA 3
233 4915.008.1-F_at −0.69917 0.69916784 9.379833   2E−15 4915.008. NM_006180.3 NM_001007097 REFSEQ 4
234 23336.002.1-T_at −0.69904 0.69903724 9.376406   2E−15 23336.002 NM_145728.1 NM_015286.4 REFSEQ 6
235 3861.008.1-C_at −0.69903 0.69902539 9.376095   2E−15 3861.008. NM_000526.3 BE184532.1 EST 1
236 3861.008.1-D_at −0.69889 0.69889457 9.372664   2E−15 3861.008. NM_000526.3 BE184532.1 EST 1
237 57447.035.1-E_at −0.69855 0.69855253 9.363704   2E−15 57447.035 NM_201535.1 BQ636638.1 EST 1
238 3861.018.1-C_at −0.69848 0.69848178 9.361852   3E−15 3861.018. NM_000526.3 BM019687.1 EST 1
239 1308.003.1-B_at −0.69839 0.69838688 9.359369   3E−15 1308.003. NM_130778.1 NM_000494.2 REFSEQ 19
240 667.022.1-B_at −0.69713 0.69712975 9.326564   3E−15 667.022.1 NM_183380.1 AX683196.1 GENBANK_PATENT 1
241 3866.011.2-T_at −0.69701 0.69700959 9.323438   3E−15 3866.011. NM_002275.2 BQ218433.1 EST 1
242 2115.001.2-F_at −0.69674 0.69674446 9.316544   3E−15 2115.001. NM_004956.3 X87175.1 mRNA 1
243 3866.011.2-B_at −0.69651 0.69651246 9.310518   3E−15 3866.011. NM_002275.2 BQ218433.1 EST 1
244 26289.010.1-T_at −0.69627 0.69627463 9.304346   3E−15 26289.010 NM_174858.1 AX988359.1 GENBANK_PATENT 1
245 27303.004.1-E_at −0.69571 0.69571431 9.28983   4E−15 27303.004 NM_001003793. BQ876639.1 EST 1
246 59.003.1-B_at −0.69503 0.69503447 9.27226   4E−15 59.003.1 NM_001613.1 DD218797.1 GENBANK_PATENT 1
247 4311.009.1-C_at −0.69487 0.69486903 9.267992   4E−15 4311.009. NM_000902.2 A30431.1 GENBANK_PATENT 1
248 7373.003.6-B_at −0.69405 0.69404745 9.246838   4E−15 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
249 65983.004.1-T_at −0.69339 0.69339166 9.230003   5E−15 65983.004 NM_023927.1 BP262020.1 EST 1
250 26289.013.1-D_at −0.69304 0.69304425 9.221102   5E−15 26289.013 NM_174858.1 CK024190.1 EST 1
251 3866.004.1-F_at −0.69262 0.6926248 9.210372   5E−15 3866.004. NM_002275.2 BC110649.1 mRNA 1
252 56477.001.1-F_at −0.69247 0.69247193 9.206466   5E−15 56477.001 NM_148672.1 NM_019846.3 REFSEQ 13
253 57447.037.1-F_at −0.69228 0.6922756 9.201453   5E−15 57447.037 NM_201535.1 BF793156.1 EST 1
254 59.022.2-T_at −0.69208 0.69207912 9.19644   6E−15 59.022.2 — — — —
255 147495.008.1-F −0.69208 0.69207819 9.196417   6E−15 147495.00 NM_153000.3 BU541433.1 EST 1
256 2.018.1-T_at −0.69207 0.69207481 9.196331   6E−15 2.018.1 NM_000014.4 DB090657.1 EST 1
257 140807.003.1-E −0.69207 0.69207171 9.196251   6E−15 140807.00 NM_080747.1 DB022590.1 EST 1
258 65983.009.1-T_at −0.69206 0.69205534 9.195834   6E−15 65983.009 NM_023927.1 CQ413222.1 GENBANK_PATENT 2
259 84668.002.1-F_at −0.69156 0.69155609 9.183115   6E−15 84668.002 NM_032581.2 AL833296.1 mRNA 20
260 3872.007.1-C_at −0.69153 0.69153411 9.182556   6E−15 3872.007. NM_000422.1 BU155457.1 EST 1
261 2115.008.1-T_at −0.69097 0.6909716 9.168257   6E−15 2115.008. NM_004956.3 BC045776.1 mRNA 3
262 65983.004.2-T_at −0.69096 0.69095787 9.167908   6E−15 65983.004 NM_023927.1 BP262020.1 EST 1
263 57447.034.1-D_at −0.69053 0.69052533 9.156935   7E−15 57447.034 NM_201535.1 BC011240.1 mRNA 1
264 3866.001.1-F_at −0.69016 0.69016212 9.147735   7E−15 3866.001. NM_002275.2 CQ733235.1 GENBANK_PATENT 23
265 3866.008.1-T_at −0.69014 0.69014281 9.147247   7E−15 3866.008. NM_002275.2 BI771363.1 EST 1
266 1959.003.1-C_at −0.68985 0.68984796 9.139789   7E−15 1959.003. NM_000399.2 BX414563.2 EST 3
267 389432.002.1-T −0.68963 0.6896308 9.134301   8E−15 389432.00 NM_001030060. CQ751492.1 GENBANK_PATENT 1
268 389734.001.1-T −0.68953 0.68953203 9.131807   8E−15 389734.00 XM_928572.1 NM_033655.2 REFSEQ 1
269 3855.001.2-D_at −0.68928 0.68928425 9.125555   8E−15 3855.001. NM_005556.3 BM754696.1 EST 1
270 3866.003.1-T_at −0.68911 0.68910803 9.121111   8E−15 3866.003. NM_002275.2 AK090604.1 mRNA 22
271 3084.006.1-F_at −0.689 0.68900076 9.118408   8E−15 3084.006. NM_013957.1 NM_013956.1 REFSEQ 3
272 4915.008.1-B_at −0.68884 0.68884477 9.114479   8E−15 4915.008. NM_006180.3 NM_001007097 REFSEQ 4
273 2115.011.1-T_at −0.68881 0.68880926 9.113585   8E−15 2115.011. NM_004956.3 DB093597.1 EST 1
274 65983.005.1-T_at −0.68876 0.68875602 9.112245   8E−15 65983.005 NM_023927.1 CQ471280.1 GENBANK_PATENT 6
275 84668.004.1-T_at −0.68808 0.68807773 9.095195   9E−15 84668.004 NM_032581.2 AL597549.1 EST 1
276 59.015.2-T_at −0.68802 0.68801589 9.093643   9E−15 59.015.2 NM_001613.1 BP372009.1 EST 1
277 2119.006.1-B_at −0.6878 0.687801 9.088252   9E−15 2119.006. NM_004454.1 DB094869.1 EST 1
278 4638.006.2-F_at −0.68764 0.6876412 9.084246   1E−14 4638.006. NM_053025.2 DR005817.1 EST 2
279 3866.007.2-D_at −0.687 0.68699646 9.068108   1E−14 3866.007. NM_002275.2 BM548942.1 EST 1
280 59.014.1-T_at −0.68691 0.68691236 9.066007   1E−14 59.014.1 NM_001613.1 CB962422.1 EST 1
281 3866.001.2-F_at −0.68681 0.68680934 9.063433   1E−14 3866.001. NM_002275.2 CQ733235.1 GENBANK_PATENT 23
282 1308.008.1-B_at −0.68652 0.68652289 9.056281   1E−14 1308.008. NM_130778.1 BE148646.1 EST 1
283 59.026.1-F_at −0.68647 0.68647292 9.055034   1E−14 59.026.1 — — — —
284 3866.013.1-T_at −0.68626 0.68625953 9.049713   1E−14 3866.013. NM_002275.2 BI769443.1 EST 1
285 1264.007.1-F_at −0.68577 0.68577484 9.037643   1E−14 1264.007. NM_001299.4 CX761868.1 EST 1
286 3866.007.2-T_at −0.68566 0.68566296 9.034861   1E−14 3866.007. NM_002275.2 BM548942.1 EST 1
287 27122.013.1-T_at −0.68541 0.68541178 9.028617   1E−14 27122.013 NM_013253.4 DR155720.1 EST 1
288 27122.006.2-T_at −0.68531 0.68531032 9.026097   1E−14 27122.006 NM_013253.4 DA171350.1 EST 1
289 3866.006.2-T_at −0.68509 0.68508881 9.020598   1E−14 3866.006. NM_002275.2 BQ641523.1 EST 1
290 3866.009.2-T_at −0.68506 0.68506091 9.019906   1E−14 3866.009. NM_002275.2 BI457146.1 EST 1
291 4240.004.1-D_at −0.68504 0.68503667 9.019305   1E−14 4240.004. NM_005928.1 BC003610.2 mRNA 448
292 3866.010.1-C_at −0.68501 0.68500991 9.018641   1E−14 3866.010. NM_002275.2 BM045201.1 EST 1
293 3866.009.2-B_at −0.68464 0.68464309 9.009548   1E−14 3866.009. NM_002275.2 BI457146.1 EST 1
294 3866.009.1-T_at −0.68457 0.68456652 9.007652   1E−14 3866.009. NM_002275.2 BI457146.1 EST 1
295 4629.006.1-T_at −0.68451 0.68450911 9.00623   1E−14 4629.006. NM_022844.1 DB079784.1 EST 1
296 7018.029.1-B_at −0.68388 0.68388329 8.990755   2E−14 7018.029. NM_001063.2 AV656085.1 EST 1
297 1410.002.2-B_at −0.68375 0.6837454 8.987351   2E−14 1410.002. NM_001885.1 AX899073.1 GENBANK_PATENT 4
298 3866.012.1-T_at −0.68307 0.68306583 8.970598   2E−14 3866.012. NM_002275.2 BI772438.1 EST 1
299 59.034.2-D_at −0.68305 0.68305272 8.970275   2E−14 59.034.2 — — — —
300 27122.019.1-F_at −0.68293 0.68293177 8.967298   2E−14 27122.019 NM_013253.4 CX758435.1 EST 1
301 5156.001.1-T_at −0.68292 0.6829222 8.967063   2E−14 5156.001. NM_006206.3 BC015186.1 mRNA 1
302 389734.001.2-T −0.68274 0.68273641 8.962493   2E−14 389734.00 XM_928572.1 NM_033655.2 REFSEQ 1
303 27122.014.1-T_at −0.68257 0.68256552 8.958292   2E−14 27122.014 NM_013253.4 DA180412.1 EST 1
304 57447.010.3-T_at −0.68236 0.68236044 8.953255   2E−14 57447.010 NM_201535.1 BP349691.1 EST 1
305 358.018.1-F_at −0.68232 0.68232244 8.952322   2E−14 358.018.1 NM_198098.1 BI765065.1 EST 1
306 3866.006.1-T_at −0.68218 0.6821773 8.948759   2E−14 3866.006. NM_002275.2 BQ641523.1 EST 1
307 7373.001.1-T_at −0.68199 0.68198548 8.944055   2E−14 7373.001. NM_021110.1 DB089175.1 EST 1
308 26289.012.1-B_at −0.68184 0.68184048 8.940501   2E−14 26289.012 NM_174858.1 BG189938.1 EST 1
309 57447.029.1-T_at −0.68178 0.68178369 8.939109   2E−14 57447.029 NM_201535.1 BX354120.2 EST 6
310 358.018.1-B_at −0.68156 0.68155712 8.933561   2E−14 358.018.1 NM_198098.1 BI765065.1 EST 1
311 79068.010.1-B_at −0.68149 0.68149173 8.93196   2E−14 79068.010 XM_051200.8 DA647247.1 EST 1
312 59.024.1-B_at −0.68126 0.68126043 8.926302   2E−14 59.024.1 — — — —
313 59.004.1-B_at −0.68117 0.68116935 8.924076   2E−14 59.004.1 NM_001613.1 CQ696293.1 GENBANK_PATENT 1
314 3866.011.1-T_at −0.68101 0.68100958 8.920172   2E−14 3866.011. NM_002275.2 BQ218433.1 EST 1
315 3866.013.1-E_at −0.68096 0.68096121 8.91899   2E−14 3866.013. NM_002275.2 BI769443.1 EST 1
316 3866.010.1-D_at −0.68032 0.68032145 8.903385   2E−14 3866.010. NM_002275.2 BM045201.1 EST 1
317 59.004.1-T_at −0.68016 0.68016229 8.899508   2E−14 59.004.1 NM_001613.1 CQ696293.1 GENBANK_PATENT 1
318 2115.012.1-T_at −0.68003 0.68003217 8.896341   2E−14 2115.012. NM_004956.3 DA407403.1 EST 1
319 2.018.1-D_at −0.68003 0.68003048 8.8963   2E−14 2.018.1 NM_000014.4 DB090657.1 EST 1
320 2115.007.1-T_at −0.67992 0.67991611 8.893517   2E−14 2115.007. NM_004956.3 DA189670.1 EST 1
321 59.040.1-T_at −0.67978 0.67977663 8.890125   2E−14 59.040.1 NM_001613.1 EH_001613.6 PREDICTED 1
322 130497.001.2-T −0.67974 0.67974133 8.889267   2E−14 130497.00 NM_145260.2 BP316395.1 EST 1
323 140885.014.1-T −0.67971 0.67971161 8.888544   2E−14 140885.01 NM_080792.2 DR423079.1 EST 1
324 3866.005.1-F_at −0.6797 0.67970122 8.888292   2E−14 3866.005. NM_002275.2 AL832226.1 mRNA 37
325 7373.003.3-F_at −0.67961 0.67961087 8.886096   3E−14 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
326 8404.028.1-F_at −0.67957 0.67957039 8.885112   3E−14 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
327 3860.007.1-D_at −0.67955 0.67954786 8.884565   3E−14 3860.007. NM_153490.1 DB256579.1 EST 1
328 4638.003.1-C_at −0.67882 0.678822 8.866957   3E−14 4638.003. NM_053025.2 BP289609.1 EST 2
329 3872.009.1-E_at −0.67861 0.67861088 8.861844   3E−14 3872.009. NM_000422.1 BX647923.1 mRNA 91
330 59.004.2-T_at −0.67859 0.67859272 8.861405   3E−14 59.004.2 NM_001613.1 CQ696293.1 GENBANK_PATENT 1
331 3872.006.1-C_at −0.67843 0.67842819 8.857424   3E−14 3872.006. NM_000422.1 BM017443.1 EST 1
332 3866.005.1-C_at −0.67822 0.67822035 8.852398   3E−14 3866.005. NM_002275.2 AL832226.1 mRNA 37
333 25925.008.1-T_at −0.67797 0.6779714 8.846384   3E−14 25925.008 NM_015461.1 DA093254.1 EST 1
334 23650.011.2-T_at −0.67792 0.67792361 8.84523   3E−14 23650.011 NM_058193.1 NM_012101.2 REFSEQ 11
335 3866.012.2-T_at −0.67755 0.67754608 8.836122   3E−14 3866.012. NM_002275.2 BI772438.1 EST 1
336 3852.017.1-D_at −0.6775 0.67750467 8.835124   3E−14 3852.017. NM_000424.2 CV575305.1 EST 1
337 4915.005.1-T_at −0.67735 0.67734733 8.831332   3E−14 4915.005. NM_006180.3 BP348402.1 EST 1
338 4638.003.1-B_at −0.67707 0.67706981 8.82465   3E−14 4638.003. NM_053025.2 BP289609.1 EST 2
339 1756.003.1-B_at −0.67674 0.67673545 8.816608   4E−14 1756.003. NM_000109.2 AB208836.1 mRNA 1
340 4638.006.1-F_at −0.67651 0.6765092 8.811172   4E−14 4638.006. NM_053025.2 DR005817.1 EST 2
341 57447.035.1-F_at −0.67604 0.67604162 8.799953   4E−14 57447.035 NM_201535.1 BQ636638.1 EST 1
342 4638.014.1-T_at −0.67585 0.67584646 8.795276   4E−14 4638.014. NM_053025.2 NM_053027.2 REFSEQ 2
343 7373.003.4-T_at −0.67582 0.67582231 8.794697   4E−14 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
344 27122.014.2-D_at −0.67579 0.67578648 8.793839   4E−14 27122.014 NM_013253.4 DA180412.1 EST 1
345 3866.007.1-T_at −0.67504 0.67503748 8.775925   4E−14 3866.007. NM_002275.2 BM548942.1 EST 1
346 2707.002.1-E_at −0.67499 0.67498884 8.774763   4E−14 2707.002. NM_024009.2 DA669405.1 EST 4
347 59.024.1-T_at −0.67481 0.67480778 8.770441   4E−14 59.024.1 — — — —
348 23650.011.1-T_at −0.6747 0.67469739 8.767807   4E−14 23650.011 NM_058193.1 NM_012101.2 REFSEQ 11
349 4638.011.1-F_at −0.67462 0.67462378 8.766052   4E−14 4638.011. NM_053025.2 DB267860.1 EST 1
350 7373.002.1-F_at −0.67455 0.67455304 8.764365   5E−14 7373.002. NM_021110.1 BC036192.1 mRNA 2
351 3866.013.1-F_at −0.6745 0.6744968 8.763024   5E−14 3866.013. NM_002275.2 BI769443.1 EST 1
352 5608.002.1-T_at −0.67444 0.67443693 8.761597   5E−14 5608.002. NM_002758.2 DA427998.1 EST 1
353 3866.001.1-C_at −0.67411 0.67411218 8.753863   5E−14 3866.001. NM_002275.2 CQ733235.1 GENBANK_PATENT 23
354 1756.013.1-B_at −0.67402 0.67402382 8.75176   5E−14 1756.013. NM_000109.2 NM_004019.1 REFSEQ 2
355 2115.006.1-E_at −0.67381 0.67381491 8.746791   5E−14 2115.006. NM_004956.3 DA210177.1 EST 1
356 6376.001.2-F_at −0.67341 0.6734055 8.737064   5E−14 6376.001. NM_002996.3 AK223351.1 mRNA 48
357 3084.004.1-B_at −0.67338 0.67337698 8.736388   5E−14 3084.004. NM_013957.1 NM_013964.1 REFSEQ 5
358 3815.002.4-F_at −0.67334 0.67333838 8.735471   5E−14 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
359 8404.002.1-D_at −0.6733 0.6733018 8.734603   5E−14 8404.002. NM_004684.2 BP383384.1 EST 1
360 1264.006.1-T_at −0.67319 0.67318534 8.73184   5E−14 1264.006. NM_001299.4 CN366945.1 EST 1
361 59.022.2-D_at −0.67316 0.67315986 8.731236   5E−14 59.022.2 — — — —
362 25925.001.1-T_at −0.67306 0.67306029 8.728874   5E−14 25925.001 NM_015461.1 BC032869.2 mRNA 19
363 4638.006.2-B_at −0.67278 0.67278344 8.722314   6E−14 4638.006. NM_053025.2 DR005817.1 EST 2
364 7373.003.5-B_at −0.67271 0.67270981 8.72057   6E−14 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
365 8404.035.1-B_at −0.6727 0.67269572 8.720236   6E−14 8404.035. NM_004684.2 BG716198.1 EST 1
366 59.012.1-T_at −0.67254 0.67254112 8.716577   6E−14 59.012.1 NM_001613.1 AL546033.3 EST 1
367 3852.017.1-T_at −0.67188 0.67188165 8.70099   6E−14 3852.017. NM_000424.2 CV575305.1 EST 1
368 3866.012.2-B_at −0.67185 0.67184565 8.70014   6E−14 3866.012. NM_002275.2 BI772438.1 EST 1
369 2.022.1-B_at −0.67169 0.67168628 8.69638   6E−14 2.022.1 NM_000014.4 BP343424.1 EST 1
370 27122.016.1-F_at −0.67125 0.67124955 8.686085   7E−14 27122.016 NM_013253.4 BQ962557.1 EST 1
371 4311.009.1-B_at −0.67109 0.67108684 8.682254   7E−14 4311.009. NM_000902.2 A30431.1 GENBANK_PATENT 1
372 59.031.2-T_at −0.67084 0.67084085 8.676467   7E−14 59.031.2 NM_001613.1 BG197213.1 EST 19
373 4311.009.1-T_at −0.67054 0.67053973 8.669389   7E−14 4311.009. NM_000902.2 A30431.1 GENBANK_PATENT 1
374 3866.006.2-B_at −0.67045 0.67044748 8.667223   7E−14 3866.006. NM_002275.2 BQ641523.1 EST 1
375 57447.025.2-T_at −0.67023 0.67022566 8.662016   7E−14 57447.025 NM_201535.1 DA646455.1 EST 2
376 1717.007.1-F_at −0.67014 0.67013656 8.659925   8E−14 1717.007. NM_001360.1 BX438503.2 EST 1
377 59.004.2-D_at −0.67008 0.67008376 8.658687   8E−14 59.004.2 NM_001613.1 CQ696293.1 GENBANK_PATENT 1
378 3866.007.2-B_at −0.66995 0.66994537 8.655442   8E−14 3866.007. NM_002275.2 BM548942.1 EST 1
379 3866.010.1-F_at −0.66945 0.66944797 8.643794   8E−14 3866.010. NM_002275.2 BM045201.1 EST 1
380 9768.004.1-D_at 0.669331 0.66933125 8.641063   8E−14 9768.004. NM_014736.4 BG506365.1 EST 2
381 3084.012.2-T_at −0.66928 0.66928297 8.639934   8E−14 3084.012. NM_013957.1 U02325.1 mRNA 1
382 1410.004.2-B_at −0.66925 0.66925228 8.639216   8E−14 1410.004. NM_001885.1 AX888027.1 GENBANK_PATENT 1
383 59.008.1-D_at −0.66919 0.66919054 8.637773   8E−14 59.008.1 NM_001613.1 BP373197.1 EST 1
384 57447.030.1-C_at −0.66908 0.66908366 8.635275   8E−14 57447.030 NM_201535.1 BM783465.1 EST 5
385 2327.002.1-D_at −0.66908 0.66907887 8.635163   8E−14 2327.002. NM_001460.2 CD684429.1 EST 1
386 1308.004.1-B_at −0.66865 0.66864754 8.625092   9E−14 1308.004. NM_130778.1 BE615666.1 EST 1
387 2568.005.2-B_at −0.66838 0.66838113 8.61888   9E−14 2568.005. NM_014211.1 AK055205.1 mRNA 11
388 2568.001.1-T_at −0.66811 0.66811257 8.612624   9E−14 2568.001. NM_014211.1 BX509618.1 EST 1
389 3084.004.2-T_at −0.66789 0.66788994 8.607442   1E−13 3084.004. NM_013957.1 NM_013964.1 REFSEQ 5
390 7373.003.4-B_at −0.66777 0.66776994 8.604651   1E−13 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
391 7153.002.2-D_at 0.667642 0.66764203 8.601677   1E−13 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
392 2893.006.2-T_at −0.66761 0.66760773 8.600879   1E−13 2893.006. NM_000829.1 BF669210.1 EST 1
393 3872.016.1-D_at −0.66759 0.66758641 8.600384   1E−13 3872.016. NM_000422.1 CB127430.1 EST 1
394 9413.006.1-F_at −0.6674 0.6674036 8.596137   1E−13 9413.006. NM_004816.2 BC021685.1 mRNA 2
395 59.023.2-B_at −0.66731 0.6673108 8.593982   1E−13 59.023.2 NM_001613.1 DB248573.1 EST 1
396 72.005.1-B_at −0.66711 0.66711142 8.589354   1E−13 72.005.1 NM_001615.3 CF130984.1 EST 20
397 4915.011.1-C_at −0.66689 0.66688915 8.5842   1E−13 4915.011. NM_006180.3 CQ723929.1 GENBANK_PATENT 1
398 27122.018.1-F_at −0.66662 0.6666247 8.578072   1E−13 27122.018 NM_013253.4 BG715341.1 EST 1
399 3852.006.1-B_at −0.66652 0.66652184 8.57569   1E−13 3852.006. NM_000424.2 BG679014.1 EST 1
400 4638.006.2-D_at −0.66649 0.66648584 8.574857   1E−13 4638.006. NM_053025.2 DR005817.1 EST 2
401 7153.005.1-E_at 0.666056 0.66605623 8.56492   1E−13 7153.005. NM_001067.2 DB061604.1 EST 1
402 7373.001.2-T_at −0.66587 0.66587031 8.560624   1E−13 7373.001. NM_021110.1 DB089175.1 EST 1
403 7018.026.1-B_at −0.66537 0.66537209 8.549127   1E−13 7018.026. NM_001063.2 BM690655.1 EST 1
404 7402.014.1-B_at −0.66525 0.66524627 8.546227   1E−13 7402.014. NM_007124.1 AL703969.1 EST 1
405 57447.010.3-D_at −0.66513 0.66513034 8.543556   1E−13 57447.010 NM_201535.1 BP349691.1 EST 1
406 140446.004.1-T −0.66502 0.66501858 8.540982   1E−13 140446.00 NM_058242.1 DB016079.1 EST 1
407 59.026.2-T_at −0.66495 0.66494798 8.539356   1E−13 59.026.2 — — — —
408 59.038.1-B_at −0.66494 0.66493959 8.539163   1E−13 59.038.1 NM_001613.1 EH_001613.2 PREDICTED 1
409 4240.009.1-C_at −0.66471 0.66470997 8.533879   1E−13 4240.009. NM_005928.1 BG829936.1 EST 2
410 57447.030.1-F_at −0.66468 0.66468295 8.533258   1E−13 57447.030 NM_201535.1 BM783465.1 EST 5
411 9768.004.1-B_at 0.664563 0.66456315 8.530503   1E−13 9768.004. NM_014736.4 BG506365.1 EST 2
412 57447.008.1-T_at −0.66453 0.66453368 8.529826   1E−13 57447.008 NM_201535.1 DB195772.1 EST 1
413 59.014.2-T_at −0.66423 0.66423397 8.52294   1E−13 59.014.2 NM_001613.1 CB962422.1 EST 1
414 4915.012.1-T_at −0.66407 0.6640741 8.51927   1E−13 4915.012. NM_006180.3 CD103051.1 EST 1
415 3866.004.1-T_at −0.66398 0.66397879 8.517083   1E−13 3866.004. NM_002275.2 BC110649.1 mRNA 1
416 2582.007.2-C_at −0.66357 0.66357028 8.507718   2E−13 2582.007. NM_001008216. AK057302.1 mRNA 32
417 7153.002.5-T_at 0.663259 0.66325931 8.500598   2E−13 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
418 4638.009.1-T_at −0.66296 0.66295877 8.493725   2E−13 4638.009. NM_053025.2 AX885051.1 GENBANK_PATENT 39
419 3861.023.1-T_at −0.66279 0.66279224 8.489919   2E−13 3861.023. NM_000526.3 BG676679.1 EST 1
420 5858.003.3-C_at −0.66243 0.66242627 8.481564   2E−13 5858.003. NM_002864.1 AX512279.1 GENBANK_PATENT 2
421 3861.020.1-F_at −0.66242 0.66241661 8.481344   2E−13 3861.020. NM_000526.3 BM018298.1 EST 1
422 147495.005.1-T −0.66232 0.66231598 8.479048   2E−13 147495.00 NM_153000.3 BI822892.1 EST 1
423 4638.006.2-C_at −0.66228 0.66227571 8.47813   2E−13 4638.006. NM_053025.2 DR005817.1 EST 2
424 1308.004.1-F_at −0.66213 0.66212634 8.474725   2E−13 1308.004. NM_130778.1 BE615666.1 EST 1
425 4915.004.1-F_at −0.66185 0.66184583 8.468335   2E−13 4915.004. NM_006180.3 NM_001018066 REFSEQ 28
426 3866.008.1-B_at −0.66173 0.66172906 8.465676   2E−13 3866.008. NM_002275.2 BI771363.1 EST 1
427 8626.002.1-E_at −0.66173 0.66172521 8.465589   2E−13 8626.002. NM_003722.3 AB016072.1 mRNA 16
428 1264.003.1-T_at −0.66156 0.66156109 8.461855   2E−13 1264.003. NM_001299.4 CV811526.1 EST 1
429 59.042.1-F_at −0.66151 0.66151227 8.460744   2E−13 59.042.1 NM_001613.1 EH_001613.8 PREDICTED 1
430 4833.004.1-C_at 0.661269 0.66126853 8.455204   2E−13 4833.004. NM_005009.2 BG478602.1 EST 8
431 2568.006.1-B_at −0.66106 0.661057 8.450399   2E−13 2568.006. NM_014211.1 CD385249.1 EST 1
432 57447.004.2-T_at −0.66103 0.66102604 8.449696   2E−13 57447.004 NM_201535.1 CD515320.1 EST 2
433 59.014.2-B_at −0.66085 0.66084763 8.445647   2E−13 59.014.2 NM_001613.1 CB962422.1 EST 1
434 3084.012.1-T_at −0.66068 0.66068046 8.441855   2E−13 3084.012. NM_013957.1 U02325.1 mRNA 1
435 27122.017.1-T_at −0.6605 0.66049978 8.43776   2E−13 27122.017 NM_013253.4 CB155251.1 EST 1
436 3852.012.2-T_at −0.66039 0.66039403 8.435364   2E−13 3852.012. NM_000424.2 CQ733668.1 GENBANK_PATENT 1
437 59.033.1-T_at −0.66029 0.66028879 8.43298   2E−13 59.033.1 — — — —
438 27122.002.1-C_at −0.66018 0.66018203 8.430563   2E−13 27122.002 NM_013253.4 AK098756.1 mRNA 1
439 3880.011.1-B_at −0.65981 0.65981353 8.422227   2E−13 3880.011. NM_002276.3 BP330400.1 EST 1
440 65983.013.1-T_at −0.65959 0.65958733 8.417116   2E−13 65983.013 NM_023927.1 AA610396.1 EST 1
441 3872.014.1-T_at −0.65949 0.65948987 8.414915   2E−13 3872.014. NM_000422.1 BG678436.1 EST 1
442 162605.001.4-C −0.65946 0.65945748 8.414184   2E−13 162605.00 NM_181535.2 CQ735954.1 GENBANK_PATENT 1
443 59.031.2-B_at −0.65937 0.65937317 8.41228   2E−13 59.031.2 NM_001613.1 BG197213.1 EST 19
444 3084.012.2-B_at −0.65926 0.65925637 8.409644   3E−13 3084.012. NM_013957.1 U02325.1 mRNA 1
445 5858.001.2-C_at −0.65925 0.65925226 8.409552   3E−13 5858.001. NM_002864.1 BC111756.1 mRNA 2
446 65983.010.1-T_at −0.65919 0.65918848 8.408113   3E−13 65983.010 NM_023927.1 DB261377.1 EST 1
447 7373.003.5-F_at −0.65893 0.65892789 8.402237   3E−13 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
448 3866.010.1-T_at −0.65871 0.65871193 8.397372   3E−13 3866.010. NM_002275.2 BM045201.1 EST 1
449 8404.005.1-B_at −0.65871 0.65870759 8.397274   3E−13 8404.005. NM_004684.2 DA763956.1 EST 1
450 3866.005.1-T_at −0.65866 0.65866359 8.396284   3E−13 3866.005. NM_002275.2 AL832226.1 mRNA 37
451 59.003.1-F_at −0.65865 0.65864902 8.395956   3E−13 59.003.1 NM_001613.1 DD218797.1 GENBANK_PATENT 1
452 7153.002.5-F_at 0.658561 0.65856119 8.393979   3E−13 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
453 2487.001.1-T_at −0.65846 0.65846487 8.391811   3E−13 2487.001. NM_001463.2 CS141780.1 GENBANK_PATENT 7
454 3866.010.1-B_at −0.6577 0.65770261 8.374683   3E−13 3866.010. NM_002275.2 BM045201.1 EST 1
455 147495.009.1-T −0.65745 0.65745477 8.369124   3E−13 147495.00 NM_153000.3 CX164031.1 EST 1
456 65983.003.2-T_at −0.65736 0.65735504 8.366888   3E−13 65983.003 NM_023927.1 BP292708.1 EST 1
457 59.040.1-D_at −0.65731 0.65731134 8.365909   3E−13 59.040.1 NM_001613.1 EH_001613.6 PREDICTED 1
458 59.024.2-T_at −0.6568 0.65679913 8.35444   3E−13 59.024.2 — — — —
459 1717.009.2-B_at −0.65673 0.65673229 8.352945   3E−13 1717.009. NM_001360.1 DB170498.1 EST 1
460 1756.027.1-F_at −0.65672 0.6567193 8.352655   3E−13 1756.027. NM_000109.2 S60971.1 mRNA 1
461 59.042.1-B_at −0.65672 0.65671619 8.352585   3E−13 59.042.1 NM_001613.1 EH_001613.8 PREDICTED 1
462 7153.002.5-D_at 0.656687 0.65668727 8.351939   3E−13 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
463 57447.031.1-F_at −0.6565 0.65650401 8.347842   3E−13 57447.031 NM_201535.1 AI272253.1 EST 1
464 140885.011.1-C −0.65642 0.6564245 8.346065   3E−13 140885.01 NM_080792.2 BM041242.1 EST 1
465 59.003.1-T_at −0.65633 0.65632979 8.34395   3E−13 59.003.1 NM_001613.1 DD218797.1 GENBANK_PATENT 1
466 3832.002.1-D_at 0.655783 0.65578291 8.331747   4E−13 3832.002. NM_004523.2 BQ959682.1 EST 1
467 3880.005.1-D_at −0.65576 0.65576275 8.331298   4E−13 3880.005. NM_002276.3 BE732853.1 EST 1
468 3084.012.1-F_at −0.65533 0.65532867 8.32163   4E−13 3084.012. NM_013957.1 U02325.1 mRNA 1
469 6595.012.1-B_at −0.65524 0.65523847 8.319622   4E−13 6595.012. NM_003070.3 DA368288.1 EST 1
470 59.012.2-D_at −0.65512 0.65511987 8.316984   4E−13 59.012.2 NM_001613.1 AL546033.3 EST 1
471 57447.034.1-C_at −0.655 0.65500441 8.314417   4E−13 57447.034 NM_201535.1 BC011240.1 mRNA 1
472 56477.001.1-B_at −0.65493 0.65492856 8.312731   4E−13 56477.001 NM_148672.1 NM_019846.3 REFSEQ 13
473 57447.041.1-D_at −0.65415 0.6541546 8.295552   4E−13 57447.041 NM_201535.1 DA295124.1 EST 1
474 9768.005.1-B_at 0.653838 0.65383824 8.288543   5E−13 9768.005. NM_014736.4 BG529193.1 EST 13
475 285203.001.2-C −0.65337 0.653374 8.278271   5E−13 285203.00 NM_173654.1 AK126187.1 mRNA 3
476 147495.006.1-B −0.65324 0.6532398 8.275305   5E−13 147495.00 NM_153000.3 CN421888.1 EST 1
477 7018.029.1-D_at −0.65323 0.65323377 8.275172   5E−13 7018.029. NM_001063.2 AV656085.1 EST 1
478 3852.009.1-T_at −0.65315 0.65314811 8.273279   5E−13 3852.009. NM_000424.2 BQ378037.1 EST 1
479 59.023.2-D_at −0.65311 0.65311489 8.272545   5E−13 59.023.2 NM_001613.1 DB248573.1 EST 1
480 1959.002.1-D_at −0.65279 0.65278556 8.265275   5E−13 1959.002. NM_000399.2 DB264199.1 EST 5
481 7018.014.1-D_at −0.65274 0.65273731 8.264211   5E−13 7018.014. NM_001063.2 AX147483.1 GENBANK_PATENT 1
482 5858.004.1-F_at −0.65256 0.65255793 8.260255   5E−13 5858.004. NM_002864.1 DB033417.1 EST 1
483 79192.002.2-D_at −0.65251 0.65251201 8.259242   5E−13 79192.002 NM_024337.3 CQ731489.1 GENBANK_PATENT 1
484 59.008.2-B_at −0.65248 0.65247737 8.258479   5E−13 59.008.2 NM_001613.1 BP373197.1 EST 1
485 8404.008.1-E_at −0.65196 0.65195548 8.246986   6E−13 8404.008. NM_004684.2 DA342341.1 EST 1
486 59.008.1-F_at −0.65193 0.65192656 8.24635   6E−13 59.008.1 NM_001613.1 BP373197.1 EST 1
487 4240.011.1-B_at −0.65168 0.65168158 8.240963   6E−13 4240.011. NM_005928.1 DA921691.1 EST 1
488 94274.002.1-C_at −0.65161 0.65161159 8.239425   6E−13 94274.002 NM_033256.1 CQ730829.1 GENBANK_PATENT 1
489 4638.015.1-T_at −0.65116 0.65115703 8.229444   6E−13 4638.015. NM_053025.2 NM_053029.2 REFSEQ 2
490 6376.001.1-T_at −0.65101 0.6510092 8.226201   6E−13 6376.001. NM_002996.3 AK223351.1 mRNA 48
491 57447.043.1-F_at −0.65059 0.65059178 8.217053   6E−13 57447.043 NM_201535.1 DA829299.1 EST 1
492 59.039.1-T_at −0.65045 0.65045393 8.214035   6E−13 59.039.1 NM_001613.1 EH_001613.4 PREDICTED 1
493 4638.006.1-B_at −0.65024 0.65023997 8.209353   7E−13 4638.006. NM_053025.2 DR005817.1 EST 2
494 25802.003.1-F_at −0.65011 0.65011381 8.206594   7E−13 25802.003 NM_012134.1 BC001755.1 mRNA 1
495 57447.025.1-T_at −0.65004 0.65003729 8.204921   7E−13 57447.025 NM_201535.1 DA646455.1 EST 2
496 57447.017.1-T_at −0.64984 0.64984134 8.20064   7E−13 57447.017 NM_201535.1 DA130260.1 EST 1
497 7018.026.1-C_at −0.64969 0.64969118 8.19736   7E−13 7018.026. NM_001063.2 BM690655.1 EST 1
498 7018.028.1-E_at −0.64913 0.64913076 8.185136   7E−13 7018.028. NM_001063.2 BX537660.1 mRNA 1
499 4915.008.1-C_at −0.64904 0.64904081 8.183176   7E−13 4915.008. NM_006180.3 NM_001007097 REFSEQ 4
500 358.018.1-C_at −0.64903 0.64902608 8.182855   7E−13 358.018.1 NM_198098.1 BI765065.1 EST 1
501 7153.002.6-B_at 0.648669 0.64866924 8.175087   8E−13 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
502 57447.012.1-T_at −0.6478 0.64780212 8.156247   9E−13 57447.012 NM_201535.1 DB294263.1 EST 1
503 59.040.1-B_at −0.6477 0.64769503 8.153924   9E−13 59.040.1 NM_001613.1 EH_001613.6 PREDICTED 1
504 57447.006.1-T_at −0.64719 0.64718891 8.142957   9E−13 57447.006 NM_201535.1 DA283861.1 EST 4
505 9493.006.1-F_at 0.646558 0.64655811 8.129315   1E−12 9493.006. NM_138555.1 BF240578.1 EST 1
506 57447.004.1-T_at −0.64628 0.64628054 8.123321   1E−12 57447.004 NM_201535.1 CD515320.1 EST 2
507 57447.004.2-B_at −0.64619 0.64619175 8.121404   1E−12 57447.004 NM_201535.1 CD515320.1 EST 2
508 7373.001.2-D_at −0.64567 0.64566532 8.110055   1E−12 7373.001. NM_021110.1 DB089175.1 EST 1
509 9493.004.1-B_at 0.64562 0.64562012 8.109081   1E−12 9493.004. NM_138555.1 BM792243.1 EST 1
510 2568.005.2-C_at −0.64555 0.64555051 8.107582   1E−12 2568.005. NM_014211.1 AK055205.1 mRNA 11
511 7018.029.1-F_at −0.64542 0.64541955 8.104763   1E−12 7018.029. NM_001063.2 AV656085.1 EST 1
512 26289.013.1-B_at −0.64525 0.64525015 8.101118   1E−12 26289.013 NM_174858.1 CK024190.1 EST 1
513 7169.015.1-B_at −0.64523 0.64522581 8.100594   1E−12 7169.015. NM_213674.1 DB291177.1 EST 1
514 57451.001.3-F_at −0.64518 0.64517957 8.0996   1E−12 57451.001 XM_931456.1 CS188752.1 GENBANK_PATENT 1
515 2568.005.2-F_at −0.64485 0.64485248 8.092569   1E−12 2568.005. NM_014211.1 AK055205.1 mRNA 11
516 57447.004.2-F_at −0.6444 0.6444048 8.082959   1E−12 57447.004 NM_201535.1 CD515320.1 EST 2
517 8404.004.1-D_at −0.64434 0.6443376 8.081518   1E−12 8404.004. NM_004684.2 DA589023.1 EST 1
518 3855.004.2-D_at −0.64418 0.6441826 8.078194   1E−12 3855.004. NM_005556.3 BU164293.1 EST 1
519 3872.014.1-F_at −0.64417 0.64416831 8.077888   1E−12 3872.014. NM_000422.1 BG678436.1 EST 1
520 57447.033.1-F_at −0.64416 0.64415874 8.077683   1E−12 57447.033 NM_201535.1 DA135222.1 EST 1
521 9452.001.1-T_at −0.64405 0.64405491 8.075458   1E−12 9452.001. NM_004867.3 BG713980.1 EST 4
522 59.033.2-T_at −0.64401 0.6440144 8.07459   1E−12 59.033.2 NM_001613.1 BQ881176.1 EST 6
523 3084.009.1-T_at −0.64398 0.64398407 8.07394   1E−12 3084.009. NM_013957.1 U02327.1 mRNA 2
524 57447.040.1-T_at −0.64395 0.6439477 8.073161   1E−12 57447.040 NM_201535.1 DA207862.1 EST 1
525 4833.004.1-T_at 0.643936 0.64393608 8.072912   1E−12 4833.004. NM_005009.2 BG478602.1 EST 8
526 3426.001.1-F_at −0.64388 0.64388211 8.071756   1E−12 3426.001. NM_000204.1 BC020718.1 mRNA 165
527 59.034.1-B_at −0.64382 0.64381551 8.07033   1E−12 59.034.1 — — — —
528 10253.001.1-E_at −0.64381 0.64381114 8.070237   1E−12 10253.001 NM_005842.2 BE297407.1 EST 1
529 9073.001.1-C_at −0.64379 0.64379361 8.069862   1E−12 9073.001. NM_199328.1 BC020866.1 mRNA 1
530 51201.005.1-T_at −0.64366 0.64366016 8.067005   1E−12 51201.005 NM_016353.2 DA655803.1 EST 1
531 9477.006.1-C_at −0.64347 0.64347364 8.063015   1E−12 9477.006. NM_004275.3 DA588860.1 EST 1
532 57447.028.1-T_at −0.64334 0.64334257 8.060213   1E−12 57447.028 NM_201535.1 DA205446.1 EST 1
533 25925.007.1-T_at −0.64319 0.64319062 8.056966   1E−12 25925.007 NM_015461.1 DA235718.1 EST 1
534 59.024.2-B_at −0.64296 0.64295617 8.051959   1E−12 59.024.2 — — — —
535 2.022.1-T_at −0.64285 0.64285401 8.049778   1E−12 2.022.1 NM_000014.4 BP343424.1 EST 1
536 4281.008.2-B_at −0.64283 0.64282648 8.04919   1E−12 4281.008. NM_033290.1 AY539984.1 mRNA 1
537 90231.001.1-C_at −0.64281 0.64281469 8.048939   1E−12 90231.001 NM_138346.1 BQ673619.1 EST 1
538 358.012.1-D_at −0.64281 0.64280918 8.048821   1E−12 358.012.1 NM_198098.1 AX597685.1 GENBANK_PATENT 1
539 3852.021.1-T_at −0.64278 0.64278273 8.048257   1E−12 3852.021. NM_000424.2 DA764437.1 EST 1
540 7373.003.4-D_at −0.64275 0.64274774 8.04751   1E−12 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
541 57447.048.1-T_at −0.64264 0.64264124 8.045239   1E−12 57447.048 NM_201535.1 BX480398.1 EST 1
542 358.012.1-B_at −0.6417 0.6417015 8.025228   2E−12 358.012.1 NM_198098.1 AX597685.1 GENBANK_PATENT 1
543 7018.025.1-C_at −0.64167 0.64166912 8.024539   2E−12 7018.025. NM_001063.2 BE971065.1 EST 1
544 5608.004.1-T_at −0.64157 0.64157449 8.022528   2E−12 5608.004. NM_002758.2 AL709891.1 EST 1
545 3084.012.2-F_at −0.64148 0.64148473 8.020621   2E−12 3084.012. NM_013957.1 U02325.1 mRNA 1
546 4306.002.1-C_at −0.64137 0.64137229 8.018232   2E−12 4306.002. NM_000901.1 AJ315515.1 mRNA 1
547 4288.004.1-D_at 0.641215 0.64121481 8.014889   2E−12 4288.004. NM_002417.2 BP232141.1 EST 1
548 57447.002.1-F_at −0.6411 0.64110459 8.012549   2E−12 57447.002 NM_201535.1 BF526188.1 EST 1
549 4281.018.1-T_at −0.64087 0.64086989 8.007571   2E−12 4281.018. NM_033290.1 AY539998.1 mRNA 1
550 10144.020.2-B_at −0.64053 0.64053304 8.000433   2E−12 10144.020 NM_014883.2 DA864231.1 EST 1
551 6876.016.1-E_at −0.64047 0.64046896 7.999075   2E−12 6876.016. NM_001001522. AB209555.1 mRNA 2
552 57447.008.2-T_at −0.64046 0.64045856 7.998855   2E−12 57447.008 NM_201535.1 DB195772.1 EST 1
553 51203.004.1-T_at 0.640272 0.64027205 7.994907   2E−12 51203.004 NM_016359.2 DB126040.1 EST 1
554 2335.028.1-B_at 0.639825 0.63982479 7.985449   2E−12 2335.028. NM_212482.1 AJ320525.1 mRNA 1
555 7018.028.1-F_at −0.63974 0.63973608 7.983575   2E−12 7018.028. NM_001063.2 BX537660.1 mRNA 1
556 7373.003.5-T_at −0.63956 0.63955526 7.979756   2E−12 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
557 81557.006.1-C_at −0.63955 0.63955366 7.979722   2E−12 81557.006 NM_030801.2 AK094541.1 mRNA 9
558 3866.002.1-D_at −0.63923 0.63923163 7.972927   2E−12 3866.002. NM_002275.2 BG990007.1 EST 1
559 3866.001.1-B_at −0.63865 0.63865251 7.960724   2E−12 3866.001. NM_002275.2 CQ733235.1 GENBANK_PATENT 23
560 55107.006.2-T_at −0.63865 0.63864972 7.960666   2E−12 55107.006 NM_018043.4 CQ722042.1 GENBANK_PATENT 1
561 79068.010.1-D_at −0.63836 0.63836198 7.954611   2E−12 79068.010 XM_051200.8 DA647247.1 EST 1
562 57447.009.1-T_at −0.63836 0.63835821 7.954532   2E−12 57447.009 NM_201535.1 BI550962.1 EST 1
563 2115.015.1-T_at −0.638 0.63799997 7.947002   2E−12 2115.015. NM_004956.3 DA220931.1 EST 1
564 1756.013.1-C_at −0.638 0.63799967 7.946996   2E−12 1756.013. NM_000109.2 NM_004019.1 REFSEQ 2
565 7169.015.1-F_at −0.63796 0.63796151 7.946194   2E−12 7169.015. NM_213674.1 DB291177.1 EST 1
566 65983.013.2-F_at −0.63792 0.63792448 7.945416   2E−12 65983.013 NM_023927.1 AA610396.1 EST 1
567 8404.001.1-B_at −0.63758 0.63757819 7.938148   2E−12 8404.001. NM_004684.2 DA132781.1 EST 1
568 4240.004.1-B_at −0.63705 0.6370484 7.927043   3E−12 4240.004. NM_005928.1 BC003610.2 mRNA 448
569 57447.012.2-T_at −0.63699 0.63699351 7.925894   3E−12 57447.012 NM_201535.1 DB294263.1 EST 1
570 57447.024.1-F_at −0.63699 0.63698737 7.925765   3E−12 57447.024 NM_201535.1 DA566498.1 EST 1
571 358.018.1-T_at −0.63696 0.63695985 7.925189   3E−12 358.018.1 NM_198098.1 BI765065.1 EST 1
572 57447.048.2-T_at −0.63688 0.6368768 7.92345   3E−12 57447.048 NM_201535.1 BX480398.1 EST 1
573 59.031.1-C_at −0.63685 0.63684644 7.922815   3E−12 59.031.1 NM_001613.1 BG197213.1 EST 19
574 3860.007.1-F_at −0.63682 0.63682338 7.922332   3E−12 3860.007. NM_153490.1 DB256579.1 EST 1
575 8404.028.1-C_at −0.63664 0.63664266 7.918551   3E−12 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
576 4240.011.3-E_at −0.63664 0.63664099 7.918517   3E−12 4240.011. NM_005928.1 DA921691.1 EST 1
577 59.022.2-B_at −0.63634 0.63633565 7.912134   3E−12 59.022.2 — — — —
578 3866.002.1-F_at −0.63598 0.63598268 7.904763   3E−12 3866.002. NM_002275.2 BG990007.1 EST 1
579 3866.002.1-T_at −0.63597 0.63596762 7.904448   3E−12 3866.002. NM_002275.2 BG990007.1 EST 1
580 4915.005.1-B_at −0.63568 0.63568404 7.898533   3E−12 4915.005. NM_006180.3 BP348402.1 EST 1
581 8404.008.1-F_at −0.63556 0.63555525 7.895848   3E−12 8404.008. NM_004684.2 DA342341.1 EST 1
582 79608.002.1-F_at −0.63554 0.63553682 7.895464   3E−12 79608.002 NM_024557.2 AK021670.1 mRNA 3
583 8404.023.1-D_at −0.63553 0.6355289 7.895299   3E−12 8404.023. NM_004684.2 BX463355.2 EST 1
584 3426.002.1-D_at −0.63533 0.63533255 7.891208   3E−12 3426.002. NM_000204.1 CQ718881.1 GENBANK_PATENT 1
585 2335.027.1-T_at 0.635297 0.63529691 7.890465   3E−12 2335.027. NM_212482.1 AJ320527.1 mRNA 1
586 11065.009.1-T_at 0.635032 0.63503202 7.884951   3E−12 11065.009 NM_181802.1 CN354813.1 EST 1
587 140885.013.1-F −0.63461 0.63461049 7.876186   3E−12 140885.01 NM_080792.2 BU180215.1 EST 1
588 57447.021.1-B_at −0.6346 0.63459853 7.875938   3E−12 57447.021 NM_201535.1 BQ954948.1 EST 28
589 25802.004.1-C_at −0.63457 0.63457163 7.875379   3E−12 25802.004 NM_012134.1 DA924386.1 EST 1
590 4638.014.1-F_at −0.63442 0.63441678 7.872162   3E−12 4638.014. NM_053025.2 NM_053027.2 REFSEQ 2
591 9493.004.1-F_at 0.634402 0.63440178 7.871851   3E−12 9493.004. NM_138555.1 BM792243.1 EST 1
592 8404.004.1-B_at −0.63427 0.63426893 7.869093   3E−12 8404.004. NM_004684.2 DA589023.1 EST 1
593 8404.004.2-T_at −0.63407 0.63407245 7.865016   3E−12 8404.004. NM_004684.2 DA589023.1 EST 1
594 57447.010.2-T_at −0.63407 0.63406601 7.864882   3E−12 57447.010 NM_201535.1 BP349691.1 EST 1
595 57447.010.3-B_at −0.634 0.6340009 7.863532   3E−12 57447.010 NM_201535.1 BP349691.1 EST 1
596 27122.006.1-T_at −0.63398 0.63398053 7.863109   3E−12 27122.006 NM_013253.4 DA171350.1 EST 1
597 5156.005.1-T_at −0.63358 0.63357822 7.854771   4E−12 5156.005. NM_006206.3 BP336054.1 EST 1
598 5858.004.1-E_at −0.63354 0.63353969 7.853973   4E−12 5858.004. NM_002864.1 DB033417.1 EST 1
599 25802.008.1-D_at −0.63342 0.63342256 7.851548   4E−12 25802.008 NM_012134.1 DA767597.1 EST 1
600 2327.002.2-T_at −0.63326 0.63326081 7.848201   4E−12 2327.002. NM_001460.2 CD684429.1 EST 1
601 3852.004.1-C_at −0.63298 0.63298294 7.842454   4E−12 3852.004. NM_000424.2 BE715131.1 EST 1
602 59.026.2-F_at −0.63296 0.63295912 7.841961   4E−12 59.026.2 — — — —
603 57447.029.1-C_at −0.63295 0.63295354 7.841846   4E−12 57447.029 NM_201535.1 BX354120.2 EST 6
604 7169.022.1-D_at −0.63293 0.63293098 7.84138   4E−12 7169.022. NM_213674.1 BG385598.1 EST 1
605 23266.001.3-B_at −0.63277 0.63276519 7.837954   4E−12 23266.001 NM_012302.2 AK123422.1 mRNA 2
606 3084.012.1-B_at −0.63235 0.63235255 7.829435   4E−12 3084.012. NM_013957.1 U02325.1 mRNA 1
607 29127.019.2-T_at 0.632352 0.63235178 7.829419   4E−12 29127.019 NM_013277.2 DA779708.1 EST 1
608 10253.004.1-T_at −0.63208 0.63208261 7.823868   4E−12 10253.004 NM_005842.2 BQ889545.1 EST 2
609 10124.002.1-D_at −0.63205 0.63205489 7.823297   4E−12 10124.002 NM_001037164. BG178114.1 EST 6
610 3861.013.1-D_at −0.63198 0.63198062 7.821766   4E−12 3861.013. NM_000526.3 BM563823.1 EST 1
611 8404.032.1-T_at −0.63197 0.63197222 7.821593   4E−12 8404.032. NM_004684.2 CQ498058.1 GENBANK_PATENT 1
612 84441.002.1-E_at −0.63188 0.63188122 7.819718   4E−12 84441.002 NM_032427.1 CQ739825.1 GENBANK_PATENT 1
613 2.013.1-E_at −0.63181 0.63181031 7.818258   4E−12 2.013.1 NM_000014.4 DA467444.1 EST 1
614 3084.004.1-T_at −0.63137 0.63136737 7.809141   4E−12 3084.004. NM_013957.1 NM_013964.1 REFSEQ 5
615 5288.001.2-F_at −0.63124 0.63123725 7.806466   5E−12 5288.001. NM_004570.2 CQ720591.1 GENBANK_PATENT 1
616 57447.017.1-F_at −0.63113 0.63113433 7.80435   5E−12 57447.017 NM_201535.1 DA130260.1 EST 1
617 3084.006.1-T_at −0.63106 0.63105508 7.802721   5E−12 3084.006. NM_013957.1 NM_013956.1 REFSEQ 3
618 59.039.1-F_at −0.63095 0.63094608 7.800482   5E−12 59.039.1 NM_001613.1 EH_001613.4 PREDICTED 1
619 2.024.1-T_at −0.63086 0.63085582 7.798628   5E−12 2.024.1 NM_000014.4 DB286897.1 EST 1
620 3815.002.2-E_at −0.63085 0.63085365 7.798584   5E−12 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
621 1756.009.1-D_at −0.63082 0.63082241 7.797942   5E−12 1756.009. NM_000109.2 NM_004023.1 REFSEQ 1
622 7091.014.1-B_at −0.63047 0.63046815 7.790673   5E−12 7091.014. NM_007005.3 BM480087.1 EST 1
623 4629.015.1-F_at −0.6304 0.63039903 7.789255   5E−12 4629.015. NM_022844.1 DB284318.1 EST 1
624 59.008.2-F_at −0.63016 0.63015808 7.784317   5E−12 59.008.2 NM_001613.1 BP373197.1 EST 1
625 2568.005.2-T_at −0.63012 0.6301238 7.783614   5E−12 2568.005. NM_014211.1 AK055205.1 mRNA 11
626 115207.002.1-T −0.62994 0.62993556 7.779759   5E−12 115207.00 NM_138444.2 CQ851144.1 GENBANK_PATENT 1
627 4281.001.1-T_at −0.62982 0.62981987 7.777391   5E−12 4281.001. NM_033290.1 AY539999.1 mRNA 1
628 84668.002.2-T_at −0.62976 0.62975676 7.776099   5E−12 84668.002 NM_032581.2 AL833296.1 mRNA 20
629 4240.004.1-F_at −0.6295 0.62950111 7.77087   5E−12 4240.004. NM_005928.1 BC003610.2 mRNA 448
630 8404.005.1-D_at −0.62918 0.62917718 7.76425   6E−12 8404.005. NM_004684.2 DA763956.1 EST 1
631 8404.032.1-B_at −0.62902 0.62902338 7.761109   6E−12 8404.032. NM_004684.2 CQ498058.1 GENBANK_PATENT 1
632 57447.044.1-E_at −0.6289 0.62890008 7.758592   6E−12 57447.044 NM_201535.1 DB232855.1 EST 1
633 8626.006.2-F_at −0.62867 0.6286676 7.753849   6E−12 8626.006. NM_003722.3 CB049427.1 EST 1
634 57447.051.2-B_at −0.62855 0.62855194 7.751491   6E−12 57447.051 NM_201535.1 BX460053.2 EST 1
635 1063.001.1-T_at 0.628003 0.62800305 7.74031   6E−12 1063.001. NM_016343.3 BG941308.1 EST 1
636 3426.002.1-T_at −0.62796 0.62796276 7.73949   6E−12 3426.002. NM_000204.1 CQ718881.1 GENBANK_PATENT 1
637 1308.001.1-T_at −0.62793 0.62793498 7.738925   6E−12 1308.001. NM_130778.1 BM773425.1 EST 1
638 389432.002.1-F −0.62759 0.62758948 7.731899   6E−12 389432.00 NM_001030060. CQ751492.1 GENBANK_PATENT 1
639 57447.017.1-B_at −0.62755 0.62754878 7.731072   7E−12 57447.017 NM_201535.1 DA130260.1 EST 1
640 2115.014.1-F_at −0.62729 0.62729339 7.725883   7E−12 2115.014. NM_004956.3 CN396909.1 EST 1
641 5284.004.1-T_at −0.62724 0.6272429 7.724858   7E−12 5284.004. NM_002644.2 DB225999.1 EST 1
642 57447.029.1-F_at −0.62716 0.6271633 7.723242   7E−12 57447.029 NM_201535.1 BX354120.2 EST 6
643 8626.006.1-F_at −0.62697 0.62697054 7.71933   7E−12 8626.006. NM_003722.3 CB049427.1 EST 1
644 2982.002.1-C_at −0.62686 0.62686245 7.717138   7E−12 2982.002. NM_000856.2 BP199345.1 EST 1
645 57447.047.1-T_at −0.62685 0.62685067 7.716899   7E−12 57447.047 NM_201535.1 DA353543.1 EST 1
646 5803.006.1-E_at −0.62682 0.62681659 7.716208   7E−12 5803.006. NM_002851.1 BM473091.1 EST 1
647 57447.021.1-F_at −0.62659 0.62658775 7.71157   7E−12 57447.021 NM_201535.1 BQ954948.1 EST 28
648 57447.039.1-F_at −0.62651 0.62651329 7.710061   7E−12 57447.039 NM_201535.1 DA356658.1 EST 1
649 4281.008.2-F_at −0.62638 0.62637927 7.707347   7E−12 4281.008. NM_033290.1 AY539984.1 mRNA 1
650 57447.029.1-D_at −0.62629 0.62629118 7.705563   7E−12 57447.029 NM_201535.1 BX354120.2 EST 6
651 65983.013.1-B_at −0.62562 0.6256189 7.691968   8E−12 65983.013 NM_023927.1 AA610396.1 EST 1
652 5284.004.1-E_at −0.62553 0.6255276 7.690123   8E−12 5284.004. NM_002644.2 DB225999.1 EST 1
653 4240.011.1-D_at −0.62513 0.62512689 7.682036   8E−12 4240.011. NM_005928.1 DA921691.1 EST 1
654 57447.024.1-T_at −0.62502 0.62502436 7.679968   8E−12 57447.024 NM_201535.1 DA566498.1 EST 1
655 6876.011.1-B_at −0.625 0.62499658 7.679408   8E−12 6876.011. NM_001001522. AW956430.1 EST 1
656 7373.003.2-T_at −0.62485 0.62484538 7.676359   8E−12 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
657 3852.014.1-D_at −0.62476 0.62476477 7.674735   9E−12 3852.014. NM_000424.2 BF826002.1 EST 1
658 4915.005.1-D_at −0.62473 0.62473239 7.674083   9E−12 4915.005. NM_006180.3 BP348402.1 EST 1
659 9768.002.2-B_at 0.624527 0.62452688 7.669944   9E−12 9768.002. NM_014736.4 BM908225.1 EST 1
660 140885.010.1-D −0.62442 0.62441747 7.667741   9E−12 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
661 4638.020.1-E_at −0.62432 0.62431859 7.665751   9E−12 4638.020. NM_053025.2 DA694890.1 EST 1
662 57447.017.1-C_at −0.62424 0.62423695 7.664109   9E−12 57447.017 NM_201535.1 DA130260.1 EST 1
663 7373.004.1-T_at −0.62423 0.6242336 7.664041   9E−12 7373.004. NM_021110.1 M64109.1 mRNA 1
664 3852.008.2-E_at −0.62396 0.62396244 7.658589   9E−12 3852.008. NM_000424.2 BG675837.1 EST 1
665 4281.015.1-E_at −0.62376 0.62376072 7.654536   9E−12 4281.015. NM_033290.1 AY540009.1 mRNA 1
666 8404.013.1-C_at −0.62375 0.62374788 7.654278   9E−12 8404.013. NM_004684.2 BP376616.1 EST 9
667 90293.001.3-T_at −0.62357 0.62357218 7.65075   1E−11 90293.001 NM_033495.2 CQ714141.1 GENBANK_PATENT 1
668 57447.044.1-T_at −0.62348 0.6234819 7.648937   1E−11 57447.044 NM_201535.1 DB232855.1 EST 1
669 23650.011.2-D_at −0.62318 0.62317705 7.642822   1E−11 23650.011 NM_058193.1 NM_012101.2 REFSEQ 11
670 2335.006.1-D_at 0.623003 0.62300327 7.639338   1E−11 2335.006. NM_212482.1 CX785805.1 EST 1
671 57447.022.1-T_at −0.6229 0.62290388 7.637347   1E−11 57447.022 NM_201535.1 DA079074.1 EST 2
672 8404.032.1-D_at −0.62271 0.62271252 7.633514   1E−11 8404.032. NM_004684.2 CQ498058.1 GENBANK_PATENT 1
673 8404.030.1-F_at −0.62267 0.62267432 7.632749   1E−11 8404.030. NM_004684.2 CD357736.1 EST 1
674 5803.002.2-T_at −0.6225 0.62250014 7.629263   1E−11 5803.002. NM_002851.1 CQ725791.1 GENBANK_PATENT 24
675 8404.004.2-C_at −0.62246 0.62245993 7.628459   1E−11 8404.004. NM_004684.2 DA589023.1 EST 1
676 84441.005.1-C_at −0.62236 0.62236291 7.626518   1E−11 84441.005 NM_032427.1 CQ739827.1 GENBANK_PATENT 1
677 7091.015.1-F_at −0.62201 0.62201208 7.619505   1E−11 7091.015. NM_007005.3 CQ724084.1 GENBANK_PATENT 1
678 2119.005.1-D_at −0.62174 0.6217418 7.614107   1E−11 2119.005. NM_004454.1 BU197295.1 EST 1
679 7373.003.6-F_at −0.6217 0.62170218 7.613316   1E−11 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
680 79608.008.1-T_at −0.6214 0.62140438 7.607374   1E−11 79608.008 NM_024557.2 DA748988.1 EST 2
681 3852.008.1-T_at −0.62129 0.62128908 7.605075   1E−11 3852.008. NM_000424.2 BG675837.1 EST 1
682 8626.007.1-T_at −0.62113 0.62113254 7.601955   1E−11 8626.007. NM_003722.3 BG698723.1 EST 1
683 8404.022.1-T_at −0.62104 0.62103797 7.60007   1E−11 8404.022. NM_004684.2 BP311988.1 EST 1
684 8404.034.1-T_at −0.62101 0.62101196 7.599552   1E−11 8404.034. NM_004684.2 DA148306.1 EST 1
685 57447.049.1-T_at −0.62097 0.62096556 7.598628   1E−11 57447.049 NM_201535.1 DB180733.1 EST 1
686 5311.002.1-B_at −0.62092 0.62092128 7.597746   1E−11 5311.002. NM_000297.2 CQ727531.1 GENBANK_PATENT 1
687 2335.025.3-T_at 0.620916 0.62091648 7.597651   1E−11 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
688 4147.012.1-T_at −0.62076 0.62075962 7.594528   1E−11 4147.012. NM_002380.3 BX397573.2 EST 1
689 301.015.1-T_at −0.62074 0.62074218 7.594181   1E−11 301.015.1 NM_000700.1 BM477702.1 EST 1
690 301.004.1-T_at −0.62073 0.62073001 7.593939   1E−11 301.004.1 NM_000700.1 DB194639.1 EST 1
691 3426.002.2-F_at −0.62048 0.62047946 7.588954   1E−11 3426.002. NM_000204.1 CQ718881.1 GENBANK_PATENT 1
692 7091.001.1-C_at −0.62037 0.62037055 7.586788   1E−11 7091.001. NM_007005.3 BC045650.1 mRNA 17
693 8404.021.1-D_at −0.62032 0.6203222 7.585827   1E−11 8404.021. NM_004684.2 DA291834.1 EST 1
694 7153.002.3-B_at 0.620304 0.62030417 7.585469   1E−11 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
695 53335.002.1-E_at −0.62026 0.62026302 7.584651   1E−11 53335.002 NM_018014.2 BU159551.1 EST 1
696 5284.003.2-T_at −0.62002 0.62001653 7.579754   1E−11 5284.003. NM_002644.2 BP220016.1 EST 1
697 4306.002.1-F_at −0.61996 0.61995574 7.578547   1E−11 4306.002. NM_000901.1 AJ315515.1 mRNA 1
698 5284.003.2-D_at −0.61991 0.61991035 7.577646   1E−11 5284.003. NM_002644.2 BP220016.1 EST 1
699 5803.002.1-T_at −0.61977 0.61977142 7.574888   1E−11 5803.002. NM_002851.1 CQ725791.1 GENBANK_PATENT 24
700 10253.004.1-E_at −0.61973 0.61973277 7.574121   1E−11 10253.004 NM_005842.2 BQ889545.1 EST 2
701 23650.020.1-T_at −0.61972 0.61971511 7.573771   1E−11 23650.020 NM_058193.1 DB266728.1 EST 1
702 57447.042.1-T_at −0.61964 0.6196367 7.572215   1E−11 57447.042 NM_201535.1 DA937014.1 EST 1
703 6876.023.1-F_at −0.6196 0.61960408 7.571568   1E−11 6876.023. NM_001001522. CN482091.1 EST 1
704 7169.015.1-C_at −0.61949 0.61948888 7.569283   1E−11 7169.015. NM_213674.1 DB291177.1 EST 1
705 7153.002.4-F_at 0.619203 0.61920323 7.563622   1E−11 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
706 4629.016.1-B_at −0.61918 0.61917512 7.563065   1E−11 4629.016. NM_022844.1 DB289769.1 EST 1
707 6876.002.1-C_at −0.61913 0.61912596 7.562091   1E−11 6876.002. NM_001001522. DB262921.1 EST 1
708 65983.007.1-T_at −0.61906 0.61905788 7.560743   1E−11 65983.007 NM_023927.1 DA388235.1 EST 1
709 7373.003.2-F_at −0.61891 0.61891452 7.557905   1E−11 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
710 152015.004.1-T −0.61872 0.61872078 7.554071   2E−11 152015.00 NM_001012337. BC015413.1 mRNA 2
711 8404.004.2-B_at −0.61824 0.61823995 7.544566   2E−11 8404.004. NM_004684.2 DA589023.1 EST 1
712 6285.001.1-B_at −0.61815 0.61815486 7.542886   2E−11 6285.001. NM_006272.1 BP349776.1 EST 1
713 2115.007.1-E_at −0.61784 0.61784158 7.536702   2E−11 2115.007. NM_004956.3 DA189670.1 EST 1
714 2.013.1-T_at −0.61782 0.61782175 7.536311   2E−11 2.013.1 NM_000014.4 DA467444.1 EST 1
715 6289.005.1-T_at −0.61778 0.6177768 7.535424   2E−11 6289.005. NM_030754.2 BG618888.1 EST 39
716 9232.002.1-T_at 0.617748 0.61774763 7.534848   2E−11 9232.002. NM_004219.2 BM459529.1 EST 2
717 59.014.1-B_at −0.61765 0.61765007 7.532925   2E−11 59.014.1 NM_001613.1 CB962422.1 EST 1
718 59.031.1-F_at −0.61751 0.61750627 7.53009   2E−11 59.031.1 NM_001613.1 BG197213.1 EST 19
719 3084.011.1-T_at −0.61746 0.61746489 7.529274   2E−11 3084.011. NM_013957.1 CN603661.1 EST 1
720 3872.005.1-F_at −0.61737 0.61737414 7.527486   2E−11 3872.005. NM_000422.1 BG682094.1 EST 1
721 3084.012.3-F_at −0.6173 0.61730492 7.526122   2E−11 3084.012. NM_013957.1 U02325.1 mRNA 1
722 81704.008.1-F_at −0.61719 0.61719009 7.523861   2E−11 81704.008 NM_203447.1 BC045629.1 mRNA 1
723 140885.010.2-C −0.617 0.61700383 7.520194   2E−11 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
724 338707.006.1-E −0.61688 0.61687839 7.517726   2E−11 338707.00 NM_178537.3 BX115728.1 EST 1
725 23266.008.2-T_at −0.61684 0.61683767 7.516924   2E−11 23266.008 NM_012302.2 CQ799210.1 GENBANK_PATENT 1
726 120.005.2-E_at −0.61665 0.61664987 7.513231   2E−11 120.005.2 NM_019903.3 AK223270.1 mRNA 78
727 4281.009.1-E_at −0.61647 0.61647345 7.509764   2E−11 4281.009. NM_033290.1 AY540014.1 mRNA 1
728 4094.001.1-T_at −0.61638 0.61638223 7.507972   2E−11 4094.001. NM_001031804. NM_005360.3 REFSEQ 17
729 2995.001.1-T_at −0.61614 0.6161404 7.503223   2E−11 2995.001. NM_002101.3 CQ729268.1 GENBANK_PATENT 1
730 4638.011.1-T_at −0.61607 0.61606684 7.501779   2E−11 4638.011. NM_053025.2 DB267860.1 EST 1
731 2335.017.1-T_at 0.615955 0.61595485 7.499582   2E−11 2335.017. NM_212482.1 CQ896577.1 GENBANK_PATENT 4
732 5284.001.1-F_at −0.61592 0.61592058 7.498909   2E−11 5284.001. NM_002644.2 AX012182.1 GENBANK_PATENT 1
733 8404.026.1-D_at −0.61589 0.61588535 7.498218   2E−11 8404.026. NM_004684.2 BX647713.1 mRNA 141
734 2335.009.1-D_at 0.615806 0.61580556 7.496653   2E−11 2335.009. NM_212482.1 BG927121.1 EST 51
735 10461.002.2-F_at −0.61571 0.61570541 7.49469   2E−11 10461.002 NM_006343.2 CQ725500.1 GENBANK_PATENT 1
736 84441.002.1-T_at −0.6157 0.61570234 7.494629   2E−11 84441.002 NM_032427.1 CQ739825.1 GENBANK_PATENT 1
737 147495.006.1-T −0.61568 0.61567688 7.49413   2E−11 147495.00 NM_153000.3 CN421888.1 EST 1
738 7091.010.1-B_at −0.61565 0.61564596 7.493524   2E−11 7091.010. NM_007005.3 AL551038.3 EST 1
739 8404.008.1-C_at −0.61554 0.61554203 7.491488   2E−11 8404.008. NM_004684.2 DA342341.1 EST 1
740 6376.001.2-C_at −0.61538 0.61538183 7.488349   2E−11 6376.001. NM_002996.3 AK223351.1 mRNA 48
741 3832.002.1-B_at 0.615014 0.61501375 7.481144   2E−11 3832.002. NM_004523.2 BQ959682.1 EST 1
742 59.034.2-T_at −0.61499 0.61498701 7.480621   2E−11 59.034.2 — — — —
743 147495.005.1-B −0.61488 0.61488109 7.478549   2E−11 147495.00 NM_153000.3 BI822892.1 EST 1
744 3872.005.1-T_at −0.61477 0.61477315 7.476439   2E−11 3872.005. NM_000422.1 BG682094.1 EST 1
745 79895.001.1-D_at −0.61472 0.61471741 7.475349   2E−11 79895.001 NM_024837.2 AX575481.1 GENBANK_PATENT 5
746 57447.038.1-T_at −0.61465 0.61464905 7.474013   2E−11 57447.038 NM_201535.1 DB238920.1 EST 1
747 7373.008.1-T_at −0.61439 0.61438569 7.468868   2E−11 7373.008. NM_021110.1 CQ656872.1 GENBANK_PATENT 1
748 4744.004.1-C_at −0.61432 0.61431915 7.467569   2E−11 4744.004. NM_021076.2 BQ636126.1 EST 1
749 140885.010.1-T −0.61432 0.61431838 7.467554   2E−11 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
750 6876.016.2-E_at −0.61423 0.61422523 7.465735   2E−11 6876.016. NM_001001522. AB209555.1 mRNA 2
751 8404.015.1-T_at −0.61419 0.61419393 7.465124   2E−11 8404.015. NM_004684.2 BP194755.1 EST 4
752 4281.014.1-T_at −0.61417 0.61416566 7.464573   2E−11 4281.014. NM_033290.1 AY539986.1 mRNA 1
753 4288.006.1-F_at 0.614163 0.61416265 7.464514   2E−11 4288.006. NM_002417.2 BP363635.1 EST 1
754 25925.009.1-E_at −0.61404 0.61403923 7.462106   2E−11 25925.009 NM_015461.1 DB064380.1 EST 1
755 4240.009.1-B_at −0.61385 0.61385445 7.458502   2E−11 4240.009. NM_005928.1 BG829936.1 EST 2
756 667.010.1-E_at −0.61376 0.61376087 7.456678   2E−11 667.010.1 NM_183380.1 DA361412.1 EST 1
757 3866.005.1-B_at −0.61345 0.61345384 7.450696   2E−11 3866.005. NM_002275.2 AL832226.1 mRNA 37
758 57447.011.1-T_at −0.61343 0.61343087 7.450249   2E−11 57447.011 NM_201535.1 BP199520.1 EST 1
759 57447.034.1-B_at −0.61342 0.61342094 7.450055   2E−11 57447.034 NM_201535.1 BC011240.1 mRNA 1
760 25802.004.1-B_at −0.61332 0.61331747 7.448041   2E−11 25802.004 NM_012134.1 DA924386.1 EST 1
761 8404.024.1-T_at −0.61318 0.61317717 7.44531   3E−11 8404.024. NM_004684.2 DB260047.1 EST 1
762 57447.032.1-T_at −0.61307 0.61306529 7.443134   3E−11 57447.032 NM_201535.1 BI771628.1 EST 3
763 667.021.1-F_at −0.61305 0.61304874 7.442812   3E−11 667.021.1 NM_183380.1 DB134537.1 EST 1
764 5858.001.2-F_at −0.61258 0.6125845 7.433788   3E−11 5858.001. NM_002864.1 BC111756.1 mRNA 2
765 51062.008.1-T_at −0.61217 0.61217313 7.425802   3E−11 51062.008 NM_015915.3 CQ719775.1 GENBANK_PATENT 1
766 2335.013.1-F_at 0.612162 0.61216233 7.425593   3E−11 2335.013. NM_212482.1 AL551632.3 EST 2
767 2568.001.2-T_at −0.61211 0.61210705 7.424521   3E−11 2568.001. NM_014211.1 BX509618.1 EST 1
768 7170.005.2-D_at 0.611952 0.61195174 7.421509   3E−11 7170.005. NM_153649.2 DA762962.1 EST 1
769 57447.034.1-F_at −0.61184 0.61184024 7.419347   3E−11 57447.034 NM_201535.1 BC011240.1 mRNA 1
770 7153.002.6-C_at 0.611814 0.61181444 7.418847   3E−11 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
771 2568.003.1-T_at −0.61165 0.61164713 7.415606   3E−11 2568.003. NM_014211.1 CD696885.1 EST 1
772 59.008.2-T_at −0.61162 0.61161827 7.415046   3E−11 59.008.2 NM_001613.1 BP373197.1 EST 1
773 9898.015.2-B_at 0.611466 0.61146611 7.4121   3E−11 9898.015. NM_014847.2 AJ243670.2 mRNA 1
774 7018.013.1-T_at −0.61122 0.6112152 7.407244   3E−11 7018.013. NM_001063.2 AX147484.1 GENBANK_PATENT 1
775 7170.034.2-D_at 0.611012 0.61101246 7.403323   3E−11 7170.034. NM_153649.2 DA894441.1 EST 1
776 3866.004.1-E_at −0.61074 0.61073542 7.397968   3E−11 3866.004. NM_002275.2 BC110649.1 mRNA 1
777 5284.001.1-T_at −0.61068 0.61067717 7.396843   3E−11 5284.001. NM_002644.2 AX012182.1 GENBANK_PATENT 1
778 2.002.1-C_at −0.61064 0.61064092 7.396143   3E−11 2.002.1 NM_000014.4 CQ672194.1 GENBANK_PATENT 1
779 57447.050.1-T_at −0.61051 0.61050599 7.393537   3E−11 57447.050 NM_201535.1 DA257961.1 EST 1
780 7018.014.1-F_at −0.61047 0.61046981 7.392839   3E−11 7018.014. NM_001063.2 AX147483.1 GENBANK_PATENT 1
781 2335.032.1-D_at 0.610251 0.61025134 7.388623   3E−11 2335.032. NM_212482.1 DA647475.1 EST 1
782 3866.002.1-C_at −0.61025 0.61024968 7.388591   3E−11 3866.002. NM_002275.2 BG990007.1 EST 1
783 57447.043.1-T_at −0.61025 0.61024544 7.388509   3E−11 57447.043 NM_201535.1 DA829299.1 EST 1
784 51201.005.1-D_at −0.61021 0.61021006 7.387827   3E−11 51201.005 NM_016353.2 DA655803.1 EST 1
785 51203.003.1-T_at 0.610008 0.61000819 7.383934   3E−11 51203.003 NM_016359.2 BP283628.1 EST 1
786 9493.001.1-F_at 0.609767 0.60976675 7.379281   3E−11 9493.001. NM_138555.1 BC051826.1 mRNA 17
787 57447.024.1-B_at −0.60944 0.60943797 7.37295   4E−11 57447.024 NM_201535.1 DA566498.1 EST 1
788 80034.003.4-B_at −0.60942 0.6094211 7.372625   4E−11 80034.003 NM_024969.2 CQ733306.1 GENBANK_PATENT 1
789 7170.016.3-C_at 0.609237 0.60923665 7.369076   4E−11 7170.016. NM_153649.2 BF575596.1 EST 1
790 65983.003.1-T_at −0.60914 0.60913896 7.367198   4E−11 65983.003 NM_023927.1 BP292708.1 EST 1
791 57447.026.1-T_at −0.60891 0.60891356 7.362865   4E−11 57447.026 NM_201535.1 BP196338.1 EST 4
792 440421.001.1-F −0.60867 0.6086702 7.35819   4E−11 440421.00 XM_496202.2 XM_934894.1 REFSEQ 2
793 301.008.1-D_at −0.60853 0.60852747 7.355449   4E−11 301.008.1 NM_000700.1 CD688703.1 EST 1
794 80034.002.2-T_at −0.60832 0.60831755 7.351421   4E−11 80034.002 NM_024969.2 DA769284.1 EST 1
795 7153.002.5-B_at 0.608304 0.60830361 7.351154   4E−11 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
796 3852.023.1-T_at −0.60821 0.60820967 7.349352   4E−11 3852.023. NM_000424.2 BG681715.1 EST 1
797 8404.013.1-F_at −0.60812 0.60812437 7.347716   4E−11 8404.013. NM_004684.2 BP376616.1 EST 9
798 2.018.1-C_at −0.60779 0.60778896 7.341289   4E−11 2.018.1 NM_000014.4 DB090657.1 EST 1
799 10124.003.1-B_at −0.60773 0.60772913 7.340143   4E−11 10124.003 NM_001037164. BU664973.1 EST 1
800 3852.008.2-F_at −0.60757 0.60757027 7.337101   4E−11 3852.008. NM_000424.2 BG675837.1 EST 1
801 4288.006.2-T_at 0.607439 0.60743897 7.334588   4E−11 4288.006. NM_002417.2 BP363635.1 EST 1
802 8404.026.1-C_at −0.60743 0.60742535 7.334327   4E−11 8404.026. NM_004684.2 BX647713.1 mRNA 141
803 23650.019.1-C_at −0.6074 0.6073959 7.333764   4E−11 23650.019 NM_058193.1 BI224541.1 EST 1
804 7170.027.1-T_at 0.607197 0.60719709 7.329961   4E−11 7170.027. NM_153649.2 BQ959117.1 EST 1
805 54928.003.1-E_at −0.60719 0.60719005 7.329827   4E−11 54928.003 NM_017813.2 DB283344.1 EST 1
806 2335.025.1-B_at 0.607111 0.60711088 7.328313   4E−11 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
807 3084.010.1-T_at −0.60698 0.60697967 7.325805   4E−11 3084.010. NM_013957.1 BC007675.2 mRNA 7
808 57447.051.1-T_at −0.60697 0.60697421 7.325701   4E−11 57447.051 NM_201535.1 BX460053.2 EST 1
809 80034.003.4-T_at −0.60692 0.6069173 7.324613   4E−11 80034.003 NM_024969.2 CQ733306.1 GENBANK_PATENT 1
810 2568.005.1-D_at −0.60678 0.6067777 7.321947   5E−11 2568.005. NM_014211.1 AK055205.1 mRNA 11
811 8404.032.1-F_at −0.60677 0.60676941 7.321788   5E−11 8404.032. NM_004684.2 CQ498058.1 GENBANK_PATENT 1
812 2115.003.1-E_at −0.60663 0.60662753 7.319079   5E−11 2115.003. NM_004956.3 DA128833.1 EST 1
813 57447.035.1-T_at −0.60656 0.60656033 7.317796   5E−11 57447.035 NM_201535.1 BQ636638.1 EST 1
814 8404.009.1-T_at −0.60613 0.60612981 7.309584   5E−11 8404.009. NM_004684.2 BP258993.1 EST 1
815 8404.028.3-B_at −0.60565 0.60564939 7.300432   5E−11 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
816 6289.003.1-B_at −0.60525 0.60524909 7.292816   5E−11 6289.003. NM_030754.2 R83510.1 EST 1
817 7170.025.1-F_at 0.604985 0.6049846 7.287789   5E−11 7170.025. NM_153649.2 BE208737.1 EST 1
818 8404.030.1-D_at −0.60498 0.60498368 7.287771   5E−11 8404.030. NM_004684.2 CD357736.1 EST 1
819 8404.009.1-F_at −0.60494 0.6049439 7.287016   5E−11 8404.009. NM_004684.2 BP258993.1 EST 1
820 2335.009.1-T_at 0.604716 0.60471597 7.282687   5E−11 2335.009. NM_212482.1 BG927121.1 EST 51
821 22974.007.1-F_at 0.604647 0.60464714 7.28138   5E−11 22974.007 NM_012112.4 AF287265.1 mRNA 213
822 3426.002.1-B_at −0.6044 0.60439543 7.276604   6E−11 3426.002. NM_000204.1 CQ718881.1 GENBANK_PATENT 1
823 4638.003.1-D_at −0.60438 0.60437577 7.276231   6E−11 4638.003. NM_053025.2 BP289609.1 EST 2
824 4147.011.1-T_at −0.6043 0.60430187 7.274829   6E−11 4147.011. NM_002380.3 BI559593.1 EST 1
825 6876.016.2-T_at −0.60425 0.60425392 7.27392   6E−11 6876.016. NM_001001522. AB209555.1 mRNA 2
826 23650.003.1-F_at −0.60408 0.60408338 7.270687   6E−11 23650.003 NM_058193.1 BI333387.1 EST 1
827 4744.004.1-E_at −0.60408 0.6040798 7.270619   6E−11 4744.004. NM_021076.2 BQ636126.1 EST 1
828 64168.010.1-F_at −0.60405 0.60404978 7.270051   6E−11 64168.010 NM_022351.2 BM985162.1 EST 1
829 9073.001.1-F_at −0.60404 0.60404345 7.269931   6E−11 9073.001. NM_199328.1 BC020866.1 mRNA 1
830 5288.001.3-B_at −0.60399 0.60398504 7.268824   6E−11 5288.001. NM_004570.2 CQ720591.1 GENBANK_PATENT 1
831 3866.005.1-D_at −0.60384 0.60383806 7.26604   6E−11 3866.005. NM_002275.2 AL832226.1 mRNA 37
832 8404.021.1-T_at −0.6038 0.60380179 7.265353   6E−11 8404.021. NM_004684.2 DA291834.1 EST 1
833 25925.011.1-E_at −0.60378 0.6037774 7.264891   6E−11 25925.011 NM_015461.1 DA105762.1 EST 1
834 23266.001.3-F_at −0.60352 0.60352263 7.260069   6E−11 23266.001 NM_012302.2 AK123422.1 mRNA 2
835 9232.004.1-F_at 0.603479 0.60347894 7.259242   6E−11 9232.004. NM_004219.2 BF983295.1 EST 1
836 4147.005.2-F_at −0.60347 0.60346555 7.258989   6E−11 4147.005. NM_002380.3 CQ716197.1 GENBANK_PATENT 1
837 2335.025.3-B_at 0.603394 0.60339429 7.257641   6E−11 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
838 4638.006.1-C_at −0.60335 0.60335253 7.256851   6E−11 4638.006. NM_053025.2 DR005817.1 EST 2
839 147804.004.1-T 0.603318 0.60331792 7.256196   6E−11 147804.00 NM_001010856. DA204897.1 EST 1
840 81704.013.1-D_at −0.60318 0.60318333 7.253652   6E−11 81704.013 NM_203447.1 CQ723361.1 GENBANK_PATENT 1
841 54443.013.1-B_at 0.603178 0.60317758 7.253543   6E−11 54443.013 NM_018685.2 BX410228.2 EST 1
842 1410.005.1-T_at −0.60301 0.60300785 7.250335   6E−11 1410.005. NM_001885.1 BM702557.1 EST 1
843 25925.009.1-T_at −0.60288 0.60287704 7.247864   6E−11 25925.009 NM_015461.1 DB064380.1 EST 1
844 3204.001.1-T_at −0.60272 0.60272058 7.24491   6E−11 3204.001. NM_006896.3 BX104300.1 EST 1
845 29997.012.1-F_at −0.60268 0.60268472 7.244233   7E−11 29997.012 NM_015710.3 BG746448.1 EST 1
846 2.005.1-C_at −0.60255 0.60254732 7.24164   7E−11 2.005.1 NM_000014.4 BI493707.1 EST 1
847 140885.011.1-F −0.60254 0.60254281 7.241555   7E−11 140885.01 NM_080792.2 BM041242.1 EST 1
848 7153.002.3-F_at 0.602528 0.60252816 7.241278   7E−11 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
849 1063.002.1-F_at 0.602485 0.60248476 7.24046   7E−11 1063.002. NM_016343.3 CQ728087.1 GENBANK_PATENT 1
850 10144.021.1-F_at −0.60221 0.60221389 7.235351   7E−11 10144.021 NM_014883.2 BG434219.1 EST 1
851 8404.025.1-E_at −0.60217 0.60217399 7.234599   7E−11 8404.025. NM_004684.2 DB086831.1 EST 1
852 6876.020.1-B_at −0.60216 0.60215903 7.234317   7E−11 6876.020. NM_001001522. BM921237.1 EST 1
853 7170.006.1-C_at 0.601994 0.6019941 7.231209   7E−11 7170.006. NM_153649.2 DB003864.1 EST 1
854 10051.016.1-T_at 0.601783 0.60178293 7.227232   7E−11 10051.016 NM_001002799. DB062440.1 EST 1
855 5288.001.2-D_at −0.60173 0.6017334 7.2263   7E−11 5288.001. NM_004570.2 CQ720591.1 GENBANK_PATENT 1
856 7018.029.1-T_at −0.60153 0.60152604 7.222397   7E−11 7018.029. NM_001063.2 AV656085.1 EST 1
857 5627.002.1-B_at −0.60134 0.6013408 7.218913   7E−11 5627.002. NM_000313.1 CQ731592.1 GENBANK_PATENT 1
858 57447.037.1-T_at −0.60118 0.60117663 7.215826   7E−11 57447.037 NM_201535.1 BF793156.1 EST 1
859 4147.005.2-D_at −0.60084 0.60084391 7.209576   8E−11 4147.005. NM_002380.3 CQ716197.1 GENBANK_PATENT 1
860 8404.023.1-T_at −0.60074 0.6007351 7.207533   8E−11 8404.023. NM_004684.2 BX463355.2 EST 1
861 3872.006.1-D_at −0.60063 0.60063372 7.20563   8E−11 3872.006. NM_000422.1 BM017443.1 EST 1
862 399687.001.1-C −0.60061 0.60060752 7.205138   8E−11 399687.00 NM_078471.3 BM922301.1 EST 2
863 3815.002.4-D_at −0.60047 0.60047483 7.202648   8E−11 3815.002. NM_000222.1 CQ719901.1 GENBANK_PATENT 1
864 59.034.2-B_at −0.60033 0.60033475 7.200021   8E−11 59.034.2 — — — —
865 8404.035.1-T_at −0.60027 0.60026583 7.198729   8E−11 8404.035. NM_004684.2 BG716198.1 EST 1
866 8404.030.1-T_at −0.60022 0.60021743 7.197822   8E−11 8404.030. NM_004684.2 CD357736.1 EST 1
867 54997.002.2-T_at −0.60016 0.60015635 7.196677   8E−11 54997.002 NM_017899.1 CQ729176.1 GENBANK_PATENT 1
868 57561.001.1-F_at −0.6001 0.60010368 7.19569   8E−11 57561.001 NM_020801.1 BQ428339.1 EST 1
869 8404.031.1-T_at −0.6 0.59999606 7.193674   8E−11 8404.031. NM_004684.2 BP327616.1 EST 1
870 2.025.1-E_at −0.59999 0.59998752 7.193514   8E−11 2.025.1 NM_000014.4 DB288732.1 EST 1
871 699.002.1-F_at 0.599982 0.59998236 7.193417   8E−11 699.002.1 NM_004336.2 CQ715813.1 GENBANK_PATENT 1
872 57447.041.1-F_at −0.59992 0.5999151 7.192157   8E−11 57447.041 NM_201535.1 DA295124.1 EST 1
873 9055.013.1-D_at 0.59986 0.59986038 7.191132   8E−11 9055.013. NM_003981.2 CN348395.1 EST 1
874 8404.008.1-D_at −0.59979 0.5997907 7.189828   8E−11 8404.008. NM_004684.2 DA342341.1 EST 1
875 7018.028.1-T_at −0.59975 0.59975341 7.189129   8E−11 7018.028. NM_001063.2 BX537660.1 mRNA 1
876 2568.005.1-T_at −0.59968 0.59967705 7.1877   8E−11 2568.005. NM_014211.1 AK055205.1 mRNA 11
877 10051.005.3-T_at 0.599532 0.59953164 7.184979   9E−11 10051.005 NM_001002799. BU183025.1 EST 1
878 2568.002.2-T_at −0.59944 0.59943802 7.183228   9E−11 2568.002. NM_014211.1 DB235581.1 EST 1
879 4147.004.1-F_at −0.59921 0.59921316 7.179023   9E−11 4147.004. NM_002380.3 AX675291.1 GENBANK_PATENT 1
880 2938.001.1-T_at −0.59919 0.59919321 7.17865   9E−11 2938.001. NM_145740.2 AV683456.1 EST 1
881 1308.007.1-E_at −0.59902 0.59902115 7.175435   9E−11 1308.007. NM_130778.1 BF916393.1 EST 1
882 2982.012.1-T_at −0.59882 0.59881603 7.171604   9E−11 2982.012. NM_000856.2 BC012627.1 mRNA 2
883 8404.028.1-D_at −0.59877 0.5987733 7.170806   9E−11 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
884 7373.001.2-B_at −0.5986 0.598602 7.167609   9E−11 7373.001. NM_021110.1 DB089175.1 EST 1
885 2893.002.2-B_at −0.59834 0.59834456 7.162807   1E−10 2893.002. NM_000829.1 DA365406.1 EST 1
886 116369.006.4-C −0.59832 0.59831944 7.162338   1E−10 116369.00 NM_052961.2 AX480884.1 GENBANK_PATENT 1
887 6304.007.1-T_at −0.59819 0.59819347 7.15999   1E−10 6304.007. NM_002971.2 DB141052.1 EST 1
888 2335.035.1-T_at 0.597963 0.5979628 7.155692   1E−10 2335.035. NM_212482.1 CX755647.1 EST 1
889 4751.002.1-T_at 0.597837 0.59783662 7.153342   1E−10 4751.002. NM_002497.2 BI464450.1 EST 1
890 64151.001.2-T_at 0.597704 0.59770416 7.150876   1E−10 64151.001 NM_022346.3 CQ729716.1 GENBANK_PATENT 2
891 29089.003.1-T_at 0.597695 0.59769515 7.150708   1E−10 29089.003 NM_014176.1 AV740591.1 EST 1
892 59.031.1-B_at −0.59762 0.59761835 7.149279   1E−10 59.031.1 NM_001613.1 BG197213.1 EST 19
893 7018.025.1-T_at −0.59758 0.59757801 7.148528   1E−10 7018.025. NM_001063.2 BE971065.1 EST 1
894 3860.008.1-T_at −0.59747 0.5974712 7.146541   1E−10 3860.008. NM_153490.1 DA668693.1 EST 1
895 5858.003.3-F_at −0.59734 0.5973382 7.144067   1E−10 5858.003. NM_002864.1 AX512279.1 GENBANK_PATENT 2
896 8404.009.1-C_at −0.59725 0.59725088 7.142444   1E−10 8404.009. NM_004684.2 BP258993.1 EST 1
897 7169.022.1-T_at −0.59719 0.59718906 7.141295   1E−10 7169.022. NM_213674.1 BG385598.1 EST 1
898 25925.006.1-T_at −0.59714 0.59714283 7.140436   1E−10 25925.006 NM_015461.1 DB276803.1 EST 1
899 59.049.1-F_at −0.59713 0.59712525 7.140109   1E−10 59.049.1 — — — —
900 5284.003.1-T_at −0.59709 0.59708796 7.139416   1E−10 5284.003. NM_002644.2 BP220016.1 EST 1
901 2982.002.1-F_at −0.59705 0.59705092 7.138728   1E−10 2982.002. NM_000856.2 BP199345.1 EST 1
902 2568.002.1-T_at −0.59693 0.59693461 7.136567   1E−10 2568.002. NM_014211.1 DB235581.1 EST 1
903 301.004.1-B_at −0.59688 0.59688305 7.135609   1E−10 301.004.1 NM_000700.1 DB194639.1 EST 1
904 25925.011.1-F_at −0.59665 0.59664856 7.131256   1E−10 25925.011 NM_015461.1 DA105762.1 EST 1
905 59.004.1-F_at −0.59647 0.59647098 7.127961   1E−10 59.004.1 NM_001613.1 CQ696293.1 GENBANK_PATENT 1
906 6289.002.1-B_at −0.59635 0.59634661 7.125655   1E−10 6289.002. NM_030754.2 AA345111.1 EST 1
907 244.003.1-C_at −0.59612 0.59612161 7.121484   1E−10 244.003.1 NM_001630.1 BM809869.1 EST 1
908 11065.008.1-C_at 0.595877 0.59587676 7.116948   1E−10 11065.008 NM_181802.1 NM_181800.1 REFSEQ 5
909 7091.006.1-T_at −0.59586 0.59586302 7.116693   1E−10 7091.006. NM_007005.3 AK057236.1 mRNA 1
910 79608.009.1-F_at −0.59581 0.59580998 7.115711   1E−10 79608.009 NM_024557.2 CA406619.1 EST 1
911 9413.002.1-T_at −0.5958 0.59580106 7.115546   1E−10 9413.002. NM_004816.2 AW779892.1 EST 1
912 7431.064.1-C_at −0.59575 0.59575257 7.114648   1E−10 7431.064. NM_003380.2 BE728213.1 EST 1
913 8404.029.1-E_at −0.5957 0.59569505 7.113583   1E−10 8404.029. NM_004684.2 AA384658.1 EST 1
914 6876.020.1-T_at −0.59541 0.59541268 7.108359   1E−10 6876.020. NM_001001522. BM921237.1 EST 1
915 301.005.1-T_at −0.59539 0.59538592 7.107864   1E−10 301.005.1 NM_000700.1 AU139656.1 EST 7
916 9055.014.1-T_at 0.59529 0.5952897 7.106085   1E−10 9055.014. NM_003981.2 BE300335.1 EST 1
917 4281.023.1-T_at −0.5952 0.59520125 7.104449   1E−10 4281.023. NM_033290.1 AY539976.1 mRNA 1
918 3868.005.1-D_at −0.59519 0.59519189 7.104276   1E−10 3868.005. NM_005557.2 BG682632.1 EST 1
919 1062.001.6-B_at 0.595002 0.59500239 7.100775   1E−10 1062.001. NM_001813.2 CQ715352.1 GENBANK_PATENT 1
920 5858.005.1-T_at −0.59493 0.5949259 7.099362   1E−10 5858.005. NM_002864.1 DB040351.1 EST 1
921 51201.007.1-F_at −0.59491 0.59490972 7.099063   1E−10 51201.007 NM_016353.2 BF541714.1 EST 1
922 4240.001.1-B_at −0.59478 0.59477936 7.096655   1E−10 4240.001. NM_005928.1 BF525404.1 EST 1
923 8404.029.1-T_at −0.59477 0.59477341 7.096546   1E−10 8404.029. NM_004684.2 AA384658.1 EST 1
924 9413.001.1-T_at −0.59469 0.59468964 7.094999   1E−10 9413.001. NM_004816.2 DA824091.1 EST 1
925 9768.005.1-T_at 0.59458 0.59458041 7.092983   1E−10 9768.005. NM_014736.4 BG529193.1 EST 13
926 11197.001.1-T_at −0.59454 0.59454222 7.092279   1E−10 11197.001 NM_007191.2 W37154.1 EST 1
927 6285.002.1-T_at −0.59451 0.59450684 7.091626   1E−10 6285.002. NM_006272.1 BQ435930.1 EST 1
928 2335.006.2-F_at 0.594359 0.59435947 7.088907   1E−10 2335.006. NM_212482.1 CX785805.1 EST 1
929 7169.001.1-C_at −0.59424 0.59424202 7.086742   1E−10 7169.001. NM_213674.1 BM809268.1 EST 4
930 9493.004.1-T_at 0.594108 0.59410838 7.084278   1E−10 9493.004. NM_138555.1 BM792243.1 EST 1
931 4601.014.1-T_at −0.59408 0.59408377 7.083825   1E−10 4601.014. NM_130439.3 AX885544.1 GENBANK_PATENT 1
932 51203.002.2-F_at 0.593876 0.59387576 7.079993   1E−10 51203.002 NM_016359.2 AL561514.3 EST 1
933 7018.022.1-F_at −0.59374 0.593741 7.077512   1E−10 7018.022. NM_001063.2 T74625.1 EST 1
934 4288.009.1-F_at 0.593675 0.59367472 7.076291   1E−10 4288.009. NM_002417.2 BG106198.1 EST 1
935 8321.004.1-D_at −0.59365 0.59365154 7.075865   1E−10 8321.004. NM_003505.1 AA249884.1 EST 1
936 8564.004.1-E_at −0.59345 0.59344954 7.072148   1E−10 8564.004. NM_003679.2 AV646525.1 EST 3
937 7169.022.1-C_at −0.59343 0.59343079 7.071803   1E−10 7169.022. NM_213674.1 BG385598.1 EST 1
938 29127.013.1-T_at 0.593386 0.59338577 7.070975   1E−10 29127.013 NM_013277.2 DA812983.1 EST 1
939 2.018.1-B_at −0.59317 0.59316746 7.066961   1E−10 2.018.1 NM_000014.4 DB090657.1 EST 1
940 2.005.1-D_at −0.59314 0.59313787 7.066417   1E−10 2.005.1 NM_000014.4 BI493707.1 EST 1
941 1058.004.2-T_at 0.5931 0.59310026 7.065726   2E−10 1058.004. NM_001809.2 AL555851.3 EST 1
942 2232.014.1-C_at −0.59284 0.59284081 7.060959   2E−10 2232.014. NM_004110.2 DB052280.1 EST 1
943 23650.005.1-E_at −0.59283 0.59282614 7.06069   2E−10 23650.005 NM_058193.1 DB116882.1 EST 1
944 5621.002.2-T_at −0.59271 0.59270593 7.058482   2E−10 5621.002. NM_000311.2 DA151722.1 EST 1
945 51201.005.1-B_at −0.5927 0.59270147 7.058401   2E−10 51201.005 NM_016353.2 DA655803.1 EST 1
946 667.022.1-F_at −0.59265 0.59265274 7.057506   2E−10 667.022.1 NM_183380.1 AX683196.1 GENBANK_PATENT 1
947 54443.012.1-C_at 0.592546 0.59254619 7.055551   2E−10 54443.012 NM_018685.2 BG167656.1 EST 1
948 25802.003.1-C_at −0.59251 0.59250565 7.054807   2E−10 25802.003 NM_012134.1 BC001755.1 mRNA 1
949 3479.003.1-T_at −0.59248 0.59247776 7.054295   2E−10 3479.003. NM_000618.2 U40870.1 mRNA 4
950 94274.003.1-D_at −0.59243 0.59242603 7.053346   2E−10 94274.003 NM_033256.1 AB056509.1 mRNA 1
951 84668.003.1-T_at −0.59229 0.5922945 7.050934   2E−10 84668.003 NM_032581.2 CQ727246.1 GENBANK_PATENT 1
952 22974.008.1-E_at 0.592131 0.59213066 7.04793   2E−10 22974.008 NM_012112.4 CQ727779.1 GENBANK_PATENT 1
953 55656.007.3-B_at 0.592104 0.59210361 7.047434   2E−10 55656.007 NM_017864.2 CQ715091.1 GENBANK_PATENT 1
954 29127.002.1-T_at 0.591958 0.59195836 7.044773   2E−10 29127.002 NM_013277.2 AB030251.1 mRNA 44
955 4281.012.2-T_at −0.59195 0.59194704 7.044565   2E−10 4281.012. NM_033290.1 CN298826.1 EST 1
956 2335.013.1-B_at 0.591874 0.59187364 7.043221   2E−10 2335.013. NM_212482.1 AL551632.3 EST 2
957 79627.003.1-B_at −0.59185 0.59184571 7.042709   2E−10 79627.003 NM_024576.3 CQ725357.1 GENBANK_PATENT 1
958 2982.014.1-T_at −0.5918 0.5918033 7.041932   2E−10 2982.014. NM_000856.2 BM469193.1 EST 1
959 2335.053.1-T_at 0.591795 0.59179543 7.041788   2E−10 2335.053. NM_212482.1 BX380854.2 EST 1
960 667.001.1-F_at −0.59167 0.5916653 7.039406   2E−10 667.001.1 NM_183380.1 BG387402.1 EST 2
961 8404.030.1-B_at −0.59165 0.59165467 7.039211   2E−10 8404.030. NM_004684.2 CD357736.1 EST 1
962 2335.025.1-C_at 0.591645 0.59164549 7.039043   2E−10 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
963 140885.010.3-D −0.59164 0.59164248 7.038988   2E−10 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
964 55366.001.2-F_at −0.59159 0.59158568 7.037948   2E−10 55366.001 NM_018490.1 CQ722924.1 GENBANK_PATENT 1
965 7169.015.1-D_at −0.59148 0.59147642 7.035949   2E−10 7169.015. NM_213674.1 DB291177.1 EST 1
966 57447.002.1-B_at −0.59141 0.59140949 7.034725   2E−10 57447.002 NM_201535.1 BF526188.1 EST 1
967 22974.008.1-T_at 0.591372 0.59137204 7.034039   2E−10 22974.008 NM_012112.4 CQ727779.1 GENBANK_PATENT 1
968 6876.011.1-C_at −0.59135 0.59135455 7.033719   2E−10 6876.011. NM_001001522. AW956430.1 EST 1
969 4281.008.2-D_at −0.59123 0.591231 7.03146   2E−10 4281.008. NM_033290.1 AY539984.1 mRNA 1
970 59.008.1-T_at −0.59118 0.59117565 7.030448   2E−10 59.008.1 NM_001613.1 BP373197.1 EST 1
971 23266.008.1-F_at −0.59109 0.59109236 7.028926   2E−10 23266.008 NM_012302.2 CQ799210.1 GENBANK_PATENT 1
972 2568.003.2-T_at −0.59089 0.59089352 7.025292   2E−10 2568.003. NM_014211.1 CD696885.1 EST 1
973 5311.003.1-T_at −0.59073 0.59073163 7.022336   2E−10 5311.003. NM_000297.2 DA153606.1 EST 1
974 6304.011.1-T_at −0.59052 0.59052216 7.018512   2E−10 6304.011. NM_002971.2 BP359118.1 EST 1
975 3861.008.1-B_at −0.59048 0.59048159 7.017772   2E−10 3861.008. NM_000526.3 BE184532.1 EST 1
976 7018.013.1-B_at −0.59035 0.59035214 7.01541   2E−10 7018.013. NM_001063.2 AX147484.1 GENBANK_PATENT 1
977 8404.005.1-F_at −0.59023 0.59022734 7.013134   2E−10 8404.005. NM_004684.2 DA763956.1 EST 1
978 7170.027.1-C_at 0.590216 0.59021624 7.012932   2E−10 7170.027. NM_153649.2 BQ959117.1 EST 1
979 8404.023.1-C_at −0.59009 0.59009089 7.010646   2E−10 8404.023. NM_004684.2 BX463355.2 EST 1
980 7373.007.1-C_at −0.59009 0.59009037 7.010637   2E−10 7373.007. NM_021110.1 Y11710.1 mRNA 1
981 1410.009.1-T_at −0.5899 0.5898986 7.007142   2E−10 1410.009. NM_001885.1 BQ437433.1 EST 2
982 79745.004.3-D_at −0.58947 0.58947272 6.999388   2E−10 79745.004 NM_024692.3 AK057267.1 mRNA 3
983 24137.004.1-T_at 0.589449 0.5894492 6.99896   2E−10 24137.004 NM_012310.2 BQ055679.1 EST 1
984 6241.013.1-B_at 0.589418 0.58941768 6.998387   2E−10 6241.013. NM_001034.1 BG261296.1 EST 1
985 1410.001.1-T_at −0.5894 0.58939515 6.997977   2E−10 1410.001. NM_001885.1 W40377.1 EST 1
986 4781.015.2-B_at −0.58938 0.5893752 6.997614   2E−10 4781.015. NM_005596.1 DN995118.1 EST 1
987 72.002.1-T_at −0.58937 0.58936787 6.99748   2E−10 72.002.1 NM_001615.3 BP372072.1 EST 2
988 4833.004.1-D_at 0.589279 0.58927851 6.995855   2E−10 4833.004. NM_005009.2 BG478602.1 EST 8
989 57447.024.1-D_at −0.58924 0.58924443 6.995235   2E−10 57447.024 NM_201535.1 DA566498.1 EST 1
990 2982.013.2-T_at −0.5892 0.58920321 6.994486   2E−10 2982.013. NM_000856.2 CF594362.1 EST 1
991 79971.012.1-T_at −0.58907 0.5890694 6.992053   2E−10 79971.012 NM_001002292. BG702604.1 EST 1
992 8404.028.3-C_at −0.589 0.58899948 6.990782   2E−10 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
993 4638.011.1-E_at −0.58897 0.58897325 6.990305   2E−10 4638.011. NM_053025.2 DB267860.1 EST 1
994 7169.004.1-C_at −0.58895 0.58894617 6.989813   2E−10 7169.004. NM_213674.1 BG027526.1 EST 1
995 4288.004.1-F_at 0.588788 0.58878813 6.986942   2E−10 4288.004. NM_002417.2 BP232141.1 EST 1
996 59.012.2-C_at −0.58875 0.58875113 6.98627   2E−10 59.012.2 NM_001613.1 AL546033.3 EST 1
997 301.008.1-B_at −0.5887 0.58869814 6.985308   2E−10 301.008.1 NM_000700.1 CD688703.1 EST 1
998 4281.012.1-T_at −0.58864 0.58863805 6.984217   2E−10 4281.012. NM_033290.1 CN298826.1 EST 1
999 2335.016.1-F_at 0.58863 0.58863031 6.984076   2E−10 2335.016. NM_212482.1 CQ875357.1 GENBANK_PATENT 281
1000 259266.003.1-C 0.588552 0.58855227 6.98266   2E−10 259266.00 NM_018136.2 CB217235.1 EST 1
1001 9055.020.1-T_at 0.588545 0.58854487 6.982525   2E−10 9055.020. NM_003981.2 BP363287.1 EST 1
1002 7091.016.1-T_at −0.58837 0.58836788 6.979313   2E−10 7091.016. NM_007005.3 DA323941.1 EST 1
1003 59.023.1-T_at −0.5882 0.58819673 6.976209   2E−10 59.023.1 NM_001613.1 DB248573.1 EST 1
1004 57162.010.1-B_at −0.58814 0.58813698 6.975125   2E−10 57162.010 NM_020651.2 DB241492.1 EST 1
1005 4781.002.2-D_at −0.58809 0.58808634 6.974207   2E−10 4781.002. NM_005596.1 BF688131.1 EST 2
1006 6122.037.1-T_at −0.58806 0.58805933 6.973718   2E−10 6122.037. NM_000967.3 BP417473.1 EST 1
1007 4240.015.1-B_at −0.58803 0.58803047 6.973195   2E−10 4240.015. NM_005928.1 AA021047.1 EST 1
1008 59.034.1-T_at −0.58783 0.58782732 6.969513   2E−10 59.034.1 — — — —
1009 8404.004.2-D_at −0.58782 0.58782345 6.969443   2E−10 8404.004. NM_004684.2 DA589023.1 EST 1
1010 9413.001.2-T_at −0.58777 0.5877726 6.968522   2E−10 9413.001. NM_004816.2 DA824091.1 EST 1
1011 2.005.1-F_at −0.58772 0.58771984 6.967566   2E−10 2.005.1 NM_000014.4 BI493707.1 EST 1
1012 6304.002.1-T_at −0.58771 0.58770553 6.967307   2E−10 6304.002. NM_002971.2 BC001744.1 mRNA 33
1013 3852.005.1-C_at −0.58768 0.58768033 6.966851   2E−10 3852.005. NM_000424.2 R47851.1 EST 1
1014 7170.027.1-B_at 0.587642 0.58764175 6.966152   2E−10 7170.027. NM_153649.2 BQ959117.1 EST 1
1015 301.013.1-T_at −0.5873 0.58729565 6.959888   2E−10 301.013.1 NM_000700.1 BF130804.1 EST 1
1016 6304.012.1-F_at −0.58724 0.58724193 6.958916   2E−10 6304.012. NM_002971.2 BP359502.1 EST 1
1017 57447.051.2-T_at −0.58722 0.58721828 6.958489   2E−10 57447.051 NM_201535.1 BX460053.2 EST 1
1018 11065.005.1-C_at 0.587192 0.58719194 6.958012   2E−10 11065.005 NM_181802.1 CS138820.1 GENBANK_PATENT 2
1019 6422.002.1-F_at −0.58719 0.58719017 6.95798   2E−10 6422.002. NM_003012.3 AX565729.1 GENBANK_PATENT 3
1020 6241.013.1-F_at 0.587043 0.58704329 6.955324   3E−10 6241.013. NM_001034.1 BG261296.1 EST 1
1021 2335.032.1-T_at 0.58699 0.58699048 6.95437   3E−10 2335.032. NM_212482.1 DA647475.1 EST 1
1022 11065.005.2-T_at 0.586925 0.5869248 6.953183   3E−10 11065.005 NM_181802.1 CS138820.1 GENBANK_PATENT 2
1023 2335.028.1-D_at 0.586789 0.58678853 6.95072   3E−10 2335.028. NM_212482.1 AJ320525.1 mRNA 1
1024 29997.016.1-F_at −0.58672 0.58671564 6.949404   3E−10 29997.016 NM_015710.3 BF686243.1 EST 1
1025 7018.014.1-T_at −0.58659 0.58658835 6.947105   3E−10 7018.014. NM_001063.2 AX147483.1 GENBANK_PATENT 1
1026 1410.011.1-E_at −0.58657 0.58657023 6.946778   3E−10 1410.011. NM_001885.1 BI561839.1 EST 1
1027 7170.040.1-E_at 0.586568 0.58656826 6.946742   3E−10 7170.040. NM_153649.2 BG283654.1 EST 1
1028 6289.002.2-F_at −0.5864 0.58639668 6.943645   3E−10 6289.002. NM_030754.2 AA345111.1 EST 1
1029 7373.003.4-C_at −0.58637 0.58636622 6.943095   3E−10 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
1030 7170.041.1-E_at 0.58605 0.58604991 6.93739   3E−10 7170.041. NM_153649.2 BF967161.1 EST 4
1031 128553.003.1-B −0.586 0.58599544 6.936408   3E−10 128553.00 NM_173485.2 BP394387.1 EST 1
1032 4094.002.1-D_at −0.58596 0.58595549 6.935688   3E−10 4094.002. NM_001031804. BI458211.1 EST 1
1033 7113.011.1-T_at −0.5859 0.58589757 6.934644   3E−10 7113.011. NM_005656.2 DA868984.1 EST 1
1034 7170.002.1-C_at 0.585876 0.58587638 6.934262   3E−10 7170.002. NM_153649.2 AL547448.3 EST 1
1035 8404.017.2-T_at −0.58585 0.58584564 6.933708   3E−10 8404.017. NM_004684.2 CD001002.1 EST 1
1036 59.029.1-T_at −0.58564 0.58563959 6.929996   3E−10 59.029.1 NM_001613.1 AL540709.3 EST 1
1037 29089.001.1-T_at 0.585601 0.58560082 6.929298   3E−10 29089.001 NM_014176.1 CA495294.1 EST 2
1038 358.012.1-T_at −0.5856 0.58559702 6.929229   3E−10 358.012.1 NM_198098.1 AX597685.1 GENBANK_PATENT 1
1039 9134.001.1-B_at 0.585561 0.58556099 6.92858   3E−10 9134.001. NM_057749.1 BC007015.1 mRNA 1
1040 2335.013.1-C_at 0.585476 0.58547585 6.927047   3E−10 2335.013. NM_212482.1 AL551632.3 EST 2
1041 1410.010.1-T_at −0.58543 0.58542981 6.926219   3E−10 1410.010. NM_001885.1 AJ710474.1 EST 2
1042 2327.003.4-F_at −0.58542 0.58541593 6.925969   3E−10 2327.003. NM_001460.2 AI223310.1 EST 1
1043 59.042.1-T_at −0.58536 0.58536256 6.925008   3E−10 59.042.1 NM_001613.1 EH_001613.8 PREDICTED 1
1044 6304.007.2-T_at −0.58518 0.58517695 6.921669   3E−10 6304.007. NM_002971.2 DB141052.1 EST 1
1045 8404.031.1-B_at −0.58502 0.5850183 6.918815   3E−10 8404.031. NM_004684.2 BP327616.1 EST 1
1046 6289.001.1-F_at −0.58499 0.58499281 6.918357   3E−10 6289.001. NM_030754.2 CR744712.1 EST 1
1047 1410.006.1-T_at −0.58487 0.58487369 6.916216   3E−10 1410.006. NM_001885.1 BF670917.1 EST 1
1048 80034.004.1-T_at −0.58483 0.58482793 6.915393   3E−10 80034.004 NM_024969.2 DA786544.1 EST 1
1049 1410.008.1-T_at −0.58477 0.58476949 6.914343   3E−10 1410.008. NM_001885.1 R68496.1 EST 1
1050 57447.051.2-D_at −0.5847 0.58469568 6.913017   3E−10 57447.051 NM_201535.1 BX460053.2 EST 1
1051 7170.016.3-B_at 0.58466 0.58466041 6.912384   3E−10 7170.016. NM_153649.2 BF575596.1 EST 1
1052 4240.001.1-C_at −0.58464 0.58463983 6.912014   3E−10 4240.001. NM_005928.1 BF525404.1 EST 1
1053 6288.001.1-T_at −0.58463 0.58462773 6.911797   3E−10 6288.001. NM_199161.1 AX899121.1 GENBANK_PATENT 2
1054 7018.014.1-C_at −0.58462 0.58461793 6.911621   3E−10 7018.014. NM_001063.2 AX147483.1 GENBANK_PATENT 1
1055 8404.020.1-T_at −0.58456 0.58455592 6.910507   3E−10 8404.020. NM_004684.2 DA298626.1 EST 1
1056 6289.001.2-F_at −0.58442 0.58441549 6.907986   3E−10 6289.001. NM_030754.2 CR744712.1 EST 1
1057 6876.011.1-F_at −0.58434 0.58433766 6.906588   3E−10 6876.011. NM_001001522. AW956430.1 EST 1
1058 8404.031.1-C_at −0.5841 0.58410499 6.902414   3E−10 8404.031. NM_004684.2 BP327616.1 EST 1
1059 57447.010.1-T_at −0.58408 0.5840791 6.90195   3E−10 57447.010 NM_201535.1 BP349691.1 EST 1
1060 1410.007.2-C_at −0.58404 0.58404076 6.901262   3E−10 1410.007. NM_001885.1 BI548180.1 EST 1
1061 59.012.2-B_at −0.58397 0.58396561 6.899914   3E−10 59.012.2 NM_001613.1 AL546033.3 EST 1
1062 3459.005.1-T_at −0.58389 0.58388527 6.898474   3E−10 3459.005. NM_000416.1 BP259682.1 EST 1
1063 301.013.1-C_at −0.58378 0.58377547 6.896506   3E−10 301.013.1 NM_000700.1 BF130804.1 EST 1
1064 83539.001.1-D_at −0.58353 0.58353306 6.892163   3E−10 83539.001 NM_031422.1 BM919514.1 EST 1
1065 6288.004.1-F_at −0.58351 0.58351232 6.891792   3E−10 6288.004. NM_199161.1 BG567754.1 EST 3
1066 4781.016.1-E_at −0.58347 0.58347336 6.891094   3E−10 4781.016. NM_005596.1 DA518562.1 EST 1
1067 29997.012.1-E_at −0.58343 0.58343189 6.890351   3E−10 29997.012 NM_015710.3 BG746448.1 EST 1
1068 57447.021.1-T_at −0.5834 0.58339709 6.889728   3E−10 57447.021 NM_201535.1 BQ954948.1 EST 28
1069 3426.002.1-C_at −0.58304 0.58304119 6.88336   4E−10 3426.002. NM_000204.1 CQ718881.1 GENBANK_PATENT 1
1070 53829.001.2-T_at −0.58296 0.58295977 6.881904   4E−10 53829.001 NM_023914.2 NM_176894.1 REFSEQ 12
1071 2115.001.2-B_at −0.58274 0.58274226 6.878015   4E−10 2115.001. NM_004956.3 X87175.1 mRNA 1
1072 10051.008.1-T_at 0.58274 0.58274024 6.877979   4E−10 10051.008 NM_001002799. DA436898.1 EST 1
1073 1033.002.1-T_at 0.582723 0.58272336 6.877677   4E−10 1033.002. NM_005192.2 BG771524.1 EST 1
1074 2335.005.1-D_at 0.582597 0.58259651 6.875411   4E−10 2335.005. NM_212482.1 BX417388.2 EST 1
1075 7113.009.1-T_at −0.58253 0.58252547 6.874142   4E−10 7113.009. NM_005656.2 DA873416.1 EST 1
1076 3866.002.1-B_at −0.58251 0.58251356 6.873929   4E−10 3866.002. NM_002275.2 BG990007.1 EST 1
1077 140885.014.1-D −0.58226 0.58225938 6.869391   4E−10 140885.01 NM_080792.2 DR423079.1 EST 1
1078 7168.003.1-T_at −0.58216 0.58215776 6.867577   4E−10 7168.003. NM_001018020. AK092051.1 mRNA 25
1079 79608.001.1-T_at −0.58215 0.58214776 6.867399   4E−10 79608.001 NM_024557.2 CQ739424.1 GENBANK_PATENT 1
1080 79608.008.2-F_at −0.58205 0.58205249 6.865699   4E−10 79608.008 NM_024557.2 DA748988.1 EST 2
1081 1410.001.1-B_at −0.58186 0.58185842 6.862238   4E−10 1410.001. NM_001885.1 W40377.1 EST 1
1082 7113.010.1-T_at −0.5816 0.5816021 6.857669   4E−10 7113.010. NM_005656.2 DA460061.1 EST 1
1083 4781.014.2-B_at −0.5816 0.58160201 6.857667   4E−10 4781.014. NM_005596.1 DN918235.1 EST 1
1084 2335.016.1-E_at 0.581544 0.58154398 6.856633   4E−10 2335.016. NM_212482.1 CQ875357.1 GENBANK_PATENT 281
1085 11065.003.1-T_at 0.581391 0.58139079 6.853905   4E−10 11065.003 NM_181802.1 CS138819.1 GENBANK_PATENT 5
1086 3872.006.1-T_at −0.58132 0.58131729 6.852596   4E−10 3872.006. NM_000422.1 BM017443.1 EST 1
1087 3084.005.1-F_at −0.58129 0.58128817 6.852078   4E−10 3084.005. NM_013957.1 NM_013960.1 REFSEQ 2
1088 6285.003.1-T_at −0.5812 0.58120469 6.850591   4E−10 6285.003. NM_006272.1 BG765453.1 EST 2
1089 6876.016.2-F_at −0.58101 0.58100573 6.847051   4E−10 6876.016. NM_001001522. AB209555.1 mRNA 2
1090 8404.004.1-T_at −0.58099 0.58098676 6.846714   4E−10 8404.004. NM_004684.2 DA589023.1 EST 1
1091 54829.001.1-F_at 0.580792 0.58079186 6.843247   4E−10 54829.001 NM_017680.3 AK027359.1 mRNA 4
1092 8404.001.1-T_at −0.58046 0.58046456 6.83743   4E−10 8404.001. NM_004684.2 DA132781.1 EST 1
1093 9055.011.1-E_at 0.580443 0.58044278 6.837043   4E−10 9055.011. NM_003981.2 CX868839.1 EST 1
1094 6289.003.2-F_at −0.58043 0.58043238 6.836859   4E−10 6289.003. NM_030754.2 R83510.1 EST 1
1095 22974.007.1-T_at 0.580276 0.5802757 6.834076   4E−10 22974.007 NM_012112.4 AF287265.1 mRNA 213
1096 59.023.2-T_at −0.58018 0.58017715 6.832326   4E−10 59.023.2 NM_001613.1 DB248573.1 EST 1
1097 7169.015.1-T_at −0.58013 0.58013361 6.831554   4E−10 7169.015. NM_213674.1 DB291177.1 EST 1
1098 6289.002.1-F_at −0.58009 0.58008892 6.83076   4E−10 6289.002. NM_030754.2 AA345111.1 EST 1
1099 4288.008.1-B_at 0.580029 0.58002917 6.8297   4E−10 4288.008. NM_002417.2 BP235232.1 EST 1
1100 4781.007.1-B_at −0.5799 0.57989557 6.82733   5E−10 4781.007. NM_005596.1 BP350370.1 EST 1
1101 6876.023.1-T_at −0.57988 0.57988374 6.82712   5E−10 6876.023. NM_001001522. CN482091.1 EST 1
1102 9055.017.1-F_at 0.579678 0.57967782 6.823468   5E−10 9055.017. NM_003981.2 DB031145.1 EST 1
1103 7170.018.2-D_at 0.579645 0.5796446 6.822879   5E−10 7170.018. NM_153649.2 DB037267.1 EST 1
1104 4781.014.2-D_at −0.57948 0.57948256 6.820008   5E−10 4781.014. NM_005596.1 DN918235.1 EST 1
1105 7170.025.1-T_at 0.579385 0.5793851 6.818281   5E−10 7170.025. NM_153649.2 BE208737.1 EST 1
1106 7018.025.1-B_at −0.57934 0.57934031 6.817488   5E−10 7018.025. NM_001063.2 BE971065.1 EST 1
1107 10253.003.1-T_at −0.57928 0.5792786 6.816395   5E−10 10253.003 NM_005842.2 DA345721.1 EST 1
1108 57447.039.1-D_at −0.57924 0.57923531 6.815628   5E−10 57447.039 NM_201535.1 DA356658.1 EST 1
1109 59.022.1-T_at −0.5792 0.57920027 6.815007   5E−10 59.022.1 NM_001613.1 BQ881176.1 EST 6
1110 2982.015.1-F_at −0.57917 0.57917337 6.814531   5E−10 2982.015. NM_000856.2 CB049566.1 EST 1
1111 10124.004.2-F_at −0.57893 0.57892871 6.810201   5E−10 10124.004 NM_001037164. BU661374.1 EST 12
1112 6289.001.1-B_at −0.57871 0.57871022 6.806336   5E−10 6289.001. NM_030754.2 CR744712.1 EST 1
1113 7091.005.1-F_at −0.57865 0.57864807 6.805237   5E−10 7091.005. NM_007005.3 BC059405.1 mRNA 1
1114 501.006.1-B_at −0.57847 0.57847445 6.802168   5E−10 501.006.1 NM_001182.2 AI142140.1 EST 1
1115 1410.001.1-C_at −0.57836 0.57835697 6.800092   5E−10 1410.001. NM_001885.1 W40377.1 EST 1
1116 57447.021.1-C_at −0.57826 0.57825824 6.798348   5E−10 57447.021 NM_201535.1 BQ954948.1 EST 28
1117 244.012.1-B_at −0.57821 0.57821349 6.797558   5E−10 244.012.1 NM_001630.1 DA445163.1 EST 1
1118 7018.026.1-F_at −0.57794 0.57793533 6.792647   5E−10 7018.026. NM_001063.2 BM690655.1 EST 1
1119 3872.018.1-T_at −0.57791 0.57790767 6.792159   5E−10 3872.018. NM_000422.1 BP226405.1 EST 1
1120 10144.017.3-T_at −0.57781 0.57781025 6.79044   5E−10 10144.017 NM_014883.2 AX747234.1 GENBANK_PATENT 1
1121 11197.001.1-F_at −0.57764 0.57763981 6.787434   5E−10 11197.001 NM_007191.2 W37154.1 EST 1
1122 29127.007.1-B_at 0.577519 0.57751875 6.785299   6E−10 29127.007 NM_013277.2 DA362566.1 EST 1
1123 10010.004.1-F_at −0.57745 0.57744716 6.784037   6E−10 10010.004 NM_004180.2 BM750784.1 EST 1
1124 81704.013.1-C_at −0.57744 0.57744059 6.783922   6E−10 81704.013 NM_203447.1 CQ723361.1 GENBANK_PATENT 1
1125 4781.006.2-B_at −0.57742 0.57742143 6.783584   6E−10 4781.006. NM_005596.1 AK131233.1 mRNA 2
1126 7373.003.1-F_at −0.57736 0.57736415 6.782575   6E−10 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
1127 8404.009.1-D_at −0.57736 0.57735822 6.78247   6E−10 8404.009. NM_004684.2 BP258993.1 EST 1
1128 23092.004.1-T_at −0.57727 0.5772653 6.780833   6E−10 23092.004 NM_015071.2 DA211853.1 EST 1
1129 2335.002.1-F_at 0.577229 0.57722889 6.780192   6E−10 2335.002. NM_212482.1 AU118498.1 EST 26
1130 8404.031.1-F_at −0.5772 0.57720205 6.779719   6E−10 8404.031. NM_004684.2 BP327616.1 EST 1
1131 6304.006.2-T_at −0.57715 0.57714631 6.778737   6E−10 6304.006. NM_002971.2 BI462843.1 EST 1
1132 1410.008.1-E_at −0.57711 0.57710598 6.778027   6E−10 1410.008. NM_001885.1 R68496.1 EST 1
1133 9055.019.1-F_at 0.577072 0.57707199 6.777428   6E−10 9055.019. NM_003981.2 AL079833.1 EST 1
1134 1398.001.1-D_at −0.57704 0.577042 6.7769   6E−10 1398.001. NM_016823.2 BE898353.1 EST 1
1135 57447.051.1-E_at −0.57704 0.57703991 6.776863   6E−10 57447.051 NM_201535.1 BX460053.2 EST 1
1136 339965.001.2-B −0.57702 0.57701808 6.776479   6E−10 339965.00 NM_178555.2 BC086869.1 mRNA 5
1137 7113.001.1-C_at −0.57697 0.57697321 6.775689   6E−10 7113.001. NM_005656.2 CQ976407.1 GENBANK_PATENT 1
1138 4240.009.1-D_at −0.57692 0.57692271 6.7748   6E−10 4240.009. NM_005928.1 BG829936.1 EST 2
1139 7153.002.4-B_at 0.576735 0.57673523 6.771501   6E−10 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
1140 7169.004.1-D_at −0.57658 0.57658017 6.768774   6E−10 7169.004. NM_213674.1 BG027526.1 EST 1
1141 1410.001.1-D_at −0.57648 0.57647869 6.766989   6E−10 1410.001. NM_001885.1 W40377.1 EST 1
1142 59.015.2-B_at −0.57634 0.57634377 6.764618   6E−10 59.015.2 NM_001613.1 BP372009.1 EST 1
1143 4833.010.1-T_at 0.576197 0.57619729 6.762044   6E−10 4833.010. NM_005009.2 BU532120.1 EST 1
1144 7169.022.1-B_at −0.57611 0.57611084 6.760525   6E−10 7169.022. NM_213674.1 BG385598.1 EST 1
1145 11065.005.1-T_at 0.576067 0.57606684 6.759752   6E−10 11065.005 NM_181802.1 CS138820.1 GENBANK_PATENT 2
1146 7170.018.2-T_at 0.575994 0.57599361 6.758466   6E−10 7170.018. NM_153649.2 DB037267.1 EST 1
1147 79971.013.2-F_at −0.57599 0.57598932 6.758391   6E−10 79971.013 NM_001002292. DA878291.1 EST 1
1148 152015.005.2-F −0.5759 0.57589713 6.756772   6E−10 152015.00 NM_001012337. CQ732372.1 GENBANK_PATENT 1
1149 4288.005.1-D_at 0.575849 0.57584855 6.75592   6E−10 4288.005. NM_002417.2 BM455229.1 EST 1
1150 8404.002.1-T_at −0.57584 0.57584028 6.755774   6E−10 8404.002. NM_004684.2 BP383384.1 EST 1
1151 6441.004.1-E_at −0.57578 0.5757767 6.754659   6E−10 6441.004. NM_003019.4 BG542824.1 EST 1
1152 6122.046.1-B_at −0.57577 0.57577128 6.754563   6E−10 6122.046. NM_000967.3 BM019962.1 EST 1
1153 115908.002.1-T 0.575641 0.57564097 6.752277   6E−10 115908.00 NM_138455.2 AF395488.1 mRNA 1
1154 9481.001.1-F_at −0.57564 0.5756408 6.752274   6E−10 9481.001. NM_004277.2 BC033091.1 mRNA 2
1155 8404.008.1-T_at −0.57561 0.57561259 6.751779   6E−10 8404.008. NM_004684.2 DA342341.1 EST 1
1156 1410.007.1-D_at −0.57559 0.57559279 6.751432   6E−10 1410.007. NM_001885.1 BI548180.1 EST 1
1157 8404.030.1-C_at −0.57555 0.57554678 6.750625   6E−10 8404.030. NM_004684.2 CD357736.1 EST 1
1158 57447.039.1-T_at −0.57552 0.57551972 6.75015   6E−10 57447.039 NM_201535.1 DA356658.1 EST 1
1159 4147.004.1-E_at −0.57546 0.57545554 6.749025   7E−10 4147.004. NM_002380.3 AX675291.1 GENBANK_PATENT 1
1160 2335.024.2-F_at 0.575372 0.57537228 6.747565   7E−10 2335.024. NM_212482.1 CQ731573.1 GENBANK_PATENT 1
1161 891.007.1-T_at 0.575369 0.57536931 6.747513   7E−10 891.007.1 NM_031966.2 BT020128.1 mRNA 1
1162 2335.002.1-T_at 0.575308 0.57530785 6.746436   7E−10 2335.002. NM_212482.1 AU118498.1 EST 26
1163 8404.017.1-T_at −0.57528 0.5752762 6.745881   7E−10 8404.017. NM_004684.2 CD001002.1 EST 1
1164 57451.004.1-B_at −0.57522 0.57521923 6.744883   7E−10 57451.004 XM_931456.1 AK056053.1 mRNA 5
1165 8404.001.1-F_at −0.57518 0.57517525 6.744112   7E−10 8404.001. NM_004684.2 DA132781.1 EST 1
1166 8626.006.2-B_at −0.57508 0.57507892 6.742424   7E−10 8626.006. NM_003722.3 CB049427.1 EST 1
1167 2335.025.1-T_at 0.575019 0.5750189 6.741373   7E−10 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
1168 6286.001.1-T_at 0.574986 0.57498586 6.740794   7E−10 6286.001. NM_005980.2 BM850288.1 EST 1
1169 10580.012.1-C_at −0.57498 0.57497814 6.740659   7E−10 10580.012 NM_015385.2 AX879149.1 GENBANK_PATENT 1
1170 23321.014.1-T_at −0.57485 0.57484627 6.73835   7E−10 23321.014 NM_015271.2 CQ723480.1 GENBANK_PATENT 1
1171 2824.001.2-B_at −0.57481 0.57480725 6.737667   7E−10 2824.001. NM_001001994. CQ717842.1 GENBANK_PATENT 1
1172 29127.022.1-T_at 0.574796 0.57479644 6.737478   7E−10 29127.022 NM_013277.2 DB065206.1 EST 1
1173 6289.003.1-F_at −0.57455 0.57455392 6.733234   7E−10 6289.003. NM_030754.2 R83510.1 EST 1
1174 7170.005.2-B_at 0.574471 0.57447114 6.731785   7E−10 7170.005. NM_153649.2 DA762962.1 EST 1
1175 54443.011.1-F_at 0.574461 0.57446085 6.731605   7E−10 54443.011 NM_018685.2 DA244113.1 EST 1
1176 29127.019.1-T_at 0.574322 0.57432168 6.729172   7E−10 29127.019 NM_013277.2 DA779708.1 EST 1
1177 6288.004.1-T_at −0.57432 0.57432014 6.729145   7E−10 6288.004. NM_199161.1 BG567754.1 EST 3
1178 29997.008.1-C_at −0.57411 0.57411065 6.725483   7E−10 29997.008 NM_015710.3 BI871613.1 EST 1
1179 57447.039.1-B_at −0.57407 0.57406597 6.724703   7E−10 57447.039 NM_201535.1 DA356658.1 EST 1
1180 3872.007.1-B_at −0.57388 0.573875 6.721367   7E−10 3872.007. NM_000422.1 BU155457.1 EST 1
1181 57561.002.1-T_at −0.57383 0.57383005 6.720582   7E−10 57561.002 NM_020801.1 DB094913.1 EST 1
1182 57451.002.3-B_at −0.57383 0.57382775 6.720542   7E−10 57451.002 XM_931456.1 AX133821.1 GENBANK_PATENT 1
1183 5213.024.1-B_at −0.57376 0.57376229 6.719399   7E−10 5213.024. NM_000289.3 CQ723196.1 GENBANK_PATENT 1
1184 2.005.1-T_at −0.57371 0.57370601 6.718416   8E−10 2.005.1 NM_000014.4 BI493707.1 EST 1
1185 11065.004.1-C_at 0.573605 0.57360463 6.716647   8E−10 11065.004 NM_181802.1 NM_181803.1 REFSEQ 3
1186 1410.006.1-C_at −0.57357 0.57356845 6.716015   8E−10 1410.006. NM_001885.1 BF670917.1 EST 1
1187 6289.006.1-T_at −0.57356 0.5735557 6.715793   8E−10 6289.006. NM_030754.2 BG618255.1 EST 3
1188 55366.001.1-T_at −0.57354 0.57353923 6.715506   8E−10 55366.001 NM_018490.1 CQ722924.1 GENBANK_PATENT 1
1189 23284.007.1-F_at −0.57343 0.57342883 6.71358   8E−10 23284.007 NM_015236.3 CX868514.1 EST 1
1190 79971.009.1-T_at −0.57327 0.573273 6.710862   8E−10 79971.009 NM_001002292. DA264864.1 EST 1
1191 6288.004.1-E_at −0.57316 0.57316396 6.708961   8E−10 6288.004. NM_199161.1 BG567754.1 EST 3
1192 11065.004.1-T_at 0.573162 0.57316172 6.708922   8E−10 11065.004 NM_181802.1 NM_181803.1 REFSEQ 3
1193 51203.009.1-T_at 0.572864 0.57286422 6.703738   8E−10 51203.009 NM_016359.2 AV714397.1 EST 1
1194 1410.010.1-E_at −0.57282 0.57282236 6.703009   8E−10 1410.010. NM_001885.1 AJ710474.1 EST 2
1195 57447.030.1-D_at −0.57277 0.57277435 6.702173   8E−10 57447.030 NM_201535.1 BM783465.1 EST 5
1196 1308.002.1-T_at −0.57253 0.57252742 6.697874   8E−10 1308.002. NM_130778.1 BX117940.1 EST 2
1197 4288.007.1-C_at 0.572423 0.57242333 6.696062   8E−10 4288.007. NM_002417.2 BE840921.1 EST 1
1198 244.011.1-T_at −0.5724 0.57240479 6.69574   8E−10 244.011.1 NM_001630.1 BX399166.2 EST 1
1199 94274.003.1-B_at −0.57238 0.57238283 6.695358   8E−10 94274.003 NM_033256.1 AB056509.1 mRNA 1
1200 3178.003.1-E_at −0.57235 0.5723545 6.694865   8E−10 3178.003. NM_031157.2 DA761057.1 EST 1
1201 7153.002.4-T_at 0.572294 0.57229362 6.693806   8E−10 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
1202 9055.012.1-D_at 0.57223 0.57222967 6.692694   8E−10 9055.012. NM_003981.2 BE298728.1 EST 1
1203 9232.001.1-E_at 0.572158 0.57215824 6.691452   8E−10 9232.001. NM_004219.2 CN285866.1 EST 1
1204 79068.011.2-B_at −0.57201 0.57200741 6.68883   9E−10 79068.011 XM_051200.8 CQ733443.1 GENBANK_PATENT 1
1205 120.005.2-F_at −0.57195 0.57194991 6.687831   9E−10 120.005.2 NM_019903.3 AK223270.1 mRNA 78
1206 7534.001.1-C_at 0.571947 0.57194717 6.687783   9E−10 7534.001. NM_003406.2 CB051503.1 EST 1
1207 120.005.2-T_at −0.57189 0.57188711 6.686739   9E−10 120.005.2 NM_019903.3 AK223270.1 mRNA 78
1208 7373.003.3-C_at −0.57177 0.57177348 6.684765   9E−10 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
1209 57447.004.2-D_at −0.57171 0.57171371 6.683727   9E−10 57447.004 NM_201535.1 CD515320.1 EST 2
1210 2568.005.1-F_at −0.57162 0.57161693 6.682047   9E−10 2568.005. NM_014211.1 AK055205.1 mRNA 11
1211 1308.001.1-E_at −0.57152 0.5715167 6.680307   9E−10 1308.001. NM_130778.1 BM773425.1 EST 1
1212 6876.020.1-F_at −0.57133 0.5713288 6.677046   9E−10 6876.020. NM_001001522. BM921237.1 EST 1
1213 79971.014.1-D_at −0.57124 0.57124451 6.675583   9E−10 79971.014 NM_001002292. DA776805.1 EST 1
1214 5621.008.1-D_at −0.57121 0.57120843 6.674957   9E−10 5621.008. NM_000311.2 DA648110.1 EST 1
1215 55732.003.2-T_at 0.571055 0.57105463 6.67229   9E−10 55732.003 NM_018186.2 DA733233.1 EST 2
1216 221120.006.1-D −0.57094 0.57093826 6.670273   9E−10 221120.00 NM_139178.1 BE892721.1 EST 1
1217 23266.008.1-T_at −0.57077 0.57076776 6.667318   9E−10 23266.008 NM_012302.2 CQ799210.1 GENBANK_PATENT 1
1218 2335.045.1-F_at 0.570754 0.57075398 6.66708   1E−09 2335.045. NM_212482.1 DA989523.1 EST 1
1219 7170.007.1-F_at 0.570733 0.57073264 6.66671   1E−09 7170.007. NM_153649.2 DA684242.1 EST 1
1220 10461.002.1-B_at −0.57071 0.57071065 6.666329   1E−09 10461.002 NM_006343.2 CQ725500.1 GENBANK_PATENT 1
1221 59.031.2-F_at −0.57071 0.57070847 6.666291   1E−09 59.031.2 NM_001613.1 BG197213.1 EST 19
1222 9055.010.1-T_at 0.570674 0.5706743 6.665699   1E−09 9055.010. NM_003981.2 BU164001.1 EST 1
1223 58499.005.2-F_at −0.5706 0.5706034 6.664471   1E−09 58499.005 NM_021224.3 BI461756.1 EST 1
1224 54443.006.2-F_at 0.570459 0.57045888 6.661969   1E−09 54443.006 NM_018685.2 CQ716589.1 GENBANK_PATENT 1
1225 59.016.1-B_at −0.57036 0.57035643 6.660196   1E−09 59.016.1 — — — —
1226 4288.004.1-C_at 0.570301 0.5703013 6.659241   1E−09 4288.004. NM_002417.2 BP232141.1 EST 1
1227 7170.014.1-C_at 0.570269 0.57026859 6.658675   1E−09 7170.014. NM_153649.2 DA690776.1 EST 1
1228 7170.007.1-D_at 0.570241 0.57024107 6.658199   1E−09 7170.007. NM_153649.2 DA684242.1 EST 1
1229 244.004.2-B_at −0.56972 0.56971798 6.649154   1E−09 244.004.2 NM_001630.1 CB115047.1 EST 1
1230 59.015.2-D_at −0.56961 0.56961045 6.647297   1E−09 59.015.2 NM_001613.1 BP372009.1 EST 1
1231 2327.002.1-B_at −0.56956 0.56955941 6.646415   1E−09 2327.002. NM_001460.2 CD684429.1 EST 1
1232 79068.011.2-C_at −0.56954 0.5695389 6.646061   1E−09 79068.011 XM_051200.8 CQ733443.1 GENBANK_PATENT 1
1233 23266.006.1-T_at −0.56936 0.56936191 6.643005   1E−09 23266.006 NM_012302.2 DR005890.1 EST 1
1234 4288.007.1-B_at 0.56932 0.56931985 6.642278   1E−09 4288.007. NM_002417.2 BE840921.1 EST 1
1235 301.008.1-T_at −0.5693 0.56929536 6.641856   1E−09 301.008.1 NM_000700.1 CD688703.1 EST 1
1236 5156.003.1-T_at −0.56918 0.56918229 6.639904   1E−09 5156.003. NM_006206.3 BP321319.1 EST 1
1237 4781.001.1-F_at −0.56917 0.56917015 6.639695   1E−09 4781.001. NM_005596.1 BF541662.1 EST 1
1238 4281.016.1-E_at −0.56916 0.56915511 6.639435   1E−09 4281.016. NM_033290.1 AY540010.1 mRNA 1
1239 72.004.1-T_at −0.5691 0.56910279 6.638533   1E−09 72.004.1 NM_001615.3 BF680547.1 EST 1
1240 57447.029.1-B_at −0.56896 0.56895732 6.636023   1E−09 57447.029 NM_201535.1 BX354120.2 EST 6
1241 79971.006.2-T_at −0.56871 0.56870809 6.631726   1E−09 79971.006 NM_001002292. DA048370.1 EST 1
1242 2327.003.2-F_at −0.56867 0.56866928 6.631058   1E−09 2327.003. NM_001460.2 AI223310.1 EST 1
1243 166824.001.2-F −0.56859 0.56858745 6.629647   1E−09 166824.00 NM_201431.1 CQ492114.1 GENBANK_PATENT 4
1244 29997.010.1-F_at −0.56857 0.56856635 6.629284   1E−09 29997.010 NM_015710.3 BG120545.1 EST 1
1245 57447.024.1-C_at −0.56853 0.56852805 6.628624   1E−09 57447.024 NM_201535.1 DA566498.1 EST 1
1246 4781.007.1-F_at −0.56839 0.56838621 6.626181   1E−09 4781.007. NM_005596.1 BP350370.1 EST 1
1247 4306.001.1-C_at −0.5682 0.56819649 6.622914   1E−09 4306.001. NM_000901.1 AJ315514.1 mRNA 5
1248 137682.002.2-T 0.568182 0.56818211 6.622667   1E−09 137682.00 NM_152416.1 BX375940.2 EST 1
1249 24137.002.1-F_at 0.568153 0.56815265 6.62216   1E−09 24137.002 NM_012310.2 BC050548.1 mRNA 1
1250 79971.006.1-T_at −0.56815 0.5681458 6.622042   1E−09 79971.006 NM_001002292. DA048370.1 EST 1
1251 7168.004.1-F_at −0.56797 0.56796804 6.618983   1E−09 7168.004. NM_001018020. BX438993.2 EST 3
1252 79068.011.1-T_at −0.56789 0.56788757 6.617599   1E−09 79068.011 XM_051200.8 CQ733443.1 GENBANK_PATENT 1
1253 4781.009.1-T_at −0.56772 0.56772333 6.614775   1E−09 4781.009. NM_005596.1 CQ732556.1 GENBANK_PATENT 1
1254 5608.003.1-T_at −0.56753 0.56752894 6.611433   1E−09 5608.003. NM_002758.2 BP220368.1 EST 1
1255 9055.014.1-D_at 0.56752 0.56752001 6.61128   1E−09 9055.014. NM_003981.2 BE300335.1 EST 1
1256 5156.009.1-F_at −0.56751 0.56750707 6.611058   1E−09 5156.009. NM_006206.3 L25829.1 mRNA 3
1257 9055.018.2-F_at 0.567502 0.56750204 6.610971   1E−09 9055.018. NM_003981.2 DA033856.1 EST 1
1258 92241.002.1-D_at −0.5675 0.56749779 6.610898   1E−09 92241.002 NM_052862.2 CQ730679.1 GENBANK_PATENT 5
1259 5010.007.1-B_at −0.56735 0.56734864 6.608336   1E−09 5010.007. NM_005602.4 BQ067107.1 EST 1
1260 2335.028.1-T_at 0.567345 0.56734544 6.608281   1E−09 2335.028. NM_212482.1 AJ320525.1 mRNA 1
1261 7113.006.1-E_at −0.56728 0.56728076 6.60717   1E−09 7113.006. NM_005656.2 DA874671.1 EST 1
1262 1756.024.1-B_at −0.56726 0.5672562 6.606748   1E−09 1756.024. NM_000109.2 CD299688.1 EST 1
1263 79971.008.2-T_at −0.56716 0.56716259 6.605141   1E−09 79971.008 NM_001002292. DA711278.1 EST 1
1264 7169.001.1-F_at −0.56705 0.56704888 6.603189   1E−09 7169.001. NM_213674.1 BM809268.1 EST 4
1265 2.022.1-D_at −0.56703 0.56702777 6.602826   1E−09 2.022.1 NM_000014.4 BP343424.1 EST 1
1266 6876.020.1-D_at −0.56697 0.56697169 6.601864   1E−09 6876.020. NM_001001522. BM921237.1 EST 1
1267 301.011.1-C_at −0.56692 0.56691975 6.600973   1E−09 301.011.1 NM_000700.1 BG435248.1 EST 1
1268 25862.005.1-E_at −0.56682 0.5668213 6.599284   1E−09 25862.005 NM_018561.3 DR003626.1 EST 1
1269 7170.047.2-D_at 0.566775 0.56677489 6.598488   1E−09 7170.047. NM_153649.2 BF693459.1 EST 1
1270 4281.010.1-T_at −0.56677 0.56677057 6.598413   1E−09 4281.010. NM_033290.1 AY540016.1 mRNA 1
1271 57447.020.1-T_at −0.56666 0.56665556 6.596441   1E−09 57447.020 NM_201535.1 BX461883.2 EST 5
1272 7170.035.2-D_at 0.566638 0.56663777 6.596136   1E−09 7170.035. NM_153649.2 BF575164.1 EST 1
1273 10124.005.1-T_at −0.56646 0.56645955 6.593081   1E−09 10124.005 NM_001037164. BU661565.1 EST 1
1274 9055.018.1-C_at 0.566425 0.56642488 6.592487   1E−09 9055.018. NM_003981.2 DA033856.1 EST 1
1275 59.038.1-T_at −0.56631 0.56630982 6.590515   1E−09 59.038.1 NM_001613.1 EH_001613.2 PREDICTED 1
1276 4288.009.1-B_at 0.566296 0.56629606 6.59028   1E−09 4288.009. NM_002417.2 BG106198.1 EST 1
1277 57561.004.1-E_at −0.5662 0.56620405 6.588704   1E−09 57561.004 NM_020801.1 DB046772.1 EST 1
1278 2568.003.2-B_at −0.56616 0.56615719 6.587901   1E−09 2568.003. NM_014211.1 CD696885.1 EST 1
1279 55713.004.1-T_at −0.56607 0.56607498 6.586493   1E−09 55713.004 NM_018102.3 AL833936.1 mRNA 1
1280 2335.026.3-F_at 0.565913 0.56591326 6.583725   1E−09 2335.026. NM_212482.1 BX641150.1 mRNA 43
1281 7168.010.1-C_at −0.56585 0.56585375 6.582706   1E−09 7168.010. NM_001018020. CD556048.1 EST 1
1282 1959.002.1-T_at −0.56583 0.56583226 6.582339   1E−09 1959.002. NM_000399.2 DB264199.1 EST 5
1283 259266.002.2-F 0.565786 0.56578622 6.581551   1E−09 259266.00 NM_018136.2 CQ729660.1 GENBANK_PATENT 1
1284 57447.010.3-C_at −0.56578 0.56578285 6.581493   1E−09 57447.010 NM_201535.1 BP349691.1 EST 1
1285 59.026.2-D_at −0.56573 0.56573398 6.580657   1E−09 59.026.2 — — — —
1286 5156.002.1-B_at −0.56572 0.56571946 6.580409   1E−09 5156.002. NM_006206.3 DB259428.1 EST 1
1287 10124.003.1-F_at −0.56572 0.56571682 6.580364   1E−09 10124.003 NM_001037164. BU664973.1 EST 1
1288 4240.007.1-T_at −0.56557 0.56556799 6.577818   1E−09 4240.007. NM_005928.1 CN485231.1 EST 1
1289 4931.007.1-F_at 0.565418 0.56541793 6.575252   1E−09 4931.007. NM_002533.2 CQ731324.1 GENBANK_PATENT 1
1290 57447.039.1-C_at −0.5653 0.56530385 6.573303   1E−09 57447.039 NM_201535.1 DA356658.1 EST 1
1291 57561.001.1-T_at −0.56529 0.56529076 6.573079   1E−09 57561.001 NM_020801.1 BQ428339.1 EST 1
1292 57447.002.1-D_at −0.56527 0.56526525 6.572643   1E−09 57447.002 NM_201535.1 BF526188.1 EST 1
1293 4094.001.1-B_at −0.56526 0.56525669 6.572497   1E−09 4094.001. NM_001031804. NM_005360.3 REFSEQ 17
1294 59.041.2-T_at −0.56524 0.56524383 6.572277   1E−09 59.041.2 NM_001613.1 AL540709.3 EST 1
1295 137682.004.2-T 0.565172 0.56517245 6.571058   1E−09 137682.00 NM_152416.1 BI670491.1 EST 1
1296 4931.011.2-T_at 0.565117 0.56511747 6.570118   1E−09 4931.011. NM_002533.2 BU170621.1 EST 1
1297 79971.010.2-T_at −0.56505 0.56505357 6.569027   1E−09 79971.010 NM_001002292. CB268343.1 EST 1
1298 29127.009.1-T_at 0.564971 0.56497093 6.567616   1E−09 29127.009 NM_013277.2 BX421176.2 EST 1
1299 2770.004.1-T_at −0.56473 0.56473004 6.563504   2E−09 2770.004. NM_002069.4 DA801873.1 EST 1
1300 59.015.2-F_at −0.56468 0.56468244 6.562692   2E−09 59.015.2 NM_001613.1 BP372009.1 EST 1
1301 2335.032.1-B_at 0.564674 0.56467386 6.562545   2E−09 2335.032. NM_212482.1 DA647475.1 EST 1
1302 1410.006.1-B_at −0.56446 0.56446046 6.558905   2E−09 1410.006. NM_001885.1 BF670917.1 EST 1
1303 79971.004.1-B_at −0.56442 0.56442019 6.558218   2E−09 79971.004 NM_001002292. BX648748.1 mRNA 2
1304 94274.003.1-T_at −0.56432 0.56432491 6.556594   2E−09 94274.003 NM_033256.1 AB056509.1 mRNA 1
1305 2335.005.1-T_at 0.564117 0.5641167 6.553045   2E−09 2335.005. NM_212482.1 BX417388.2 EST 1
1306 966.004.2-B_at −0.56412 0.56411646 6.553041   2E−09 966.004.2 NM_203330.1 AU117114.1 EST 3
1307 79780.006.1-B_at −0.56406 0.5640582 6.552049   2E−09 79780.006 NM_024725.2 BG570666.1 EST 1
1308 57561.003.1-T_at −0.56392 0.56392094 6.549711   2E−09 57561.003 NM_020801.1 DA797962.1 EST 1
1309 9073.002.1-B_at −0.56389 0.56389001 6.549184   2E−09 9073.002. NM_199328.1 BP277133.1 EST 1
1310 55656.014.2-F_at 0.56379 0.56378984 6.547479   2E−09 55656.014 NM_017864.2 BF770934.1 EST 1
1311 2335.035.1-B_at 0.563724 0.56372399 6.546357   2E−09 2335.035. NM_212482.1 CX755647.1 EST 1
1312 3161.005.1-T_at 0.563648 0.56364847 6.545072   2E−09 3161.005. NM_012484.1 AX675838.1 GENBANK_PATENT 1
1313 57451.006.1-B_at −0.56362 0.56362219 6.544625   2E−09 57451.006 XM_931456.1 AL598057.1 EST 1
1314 2568.004.1-T_at −0.56349 0.56348518 6.542294   2E−09 2568.004. NM_014211.1 BP342098.1 EST 1
1315 440073.003.1-E −0.56329 0.56329195 6.539007   2E−09 440073.00 NM_015232.1 BX110676.1 EST 1
1316 2335.006.1-T_at 0.563204 0.56320431 6.537517   2E−09 2335.006. NM_212482.1 CX785805.1 EST 1
1317 10051.011.2-T_at 0.563182 0.56318212 6.53714   2E−09 10051.011 NM_001002799. BG776861.1 EST 4
1318 55784.003.1-T_at −0.56304 0.56303549 6.534648   2E−09 55784.003 NM_018349.2 BC025708.1 mRNA 2
1319 3860.010.1-T_at −0.56302 0.56302355 6.534445   2E−09 3860.010. NM_153490.1 DA441591.1 EST 1
1320 5284.001.1-D_at −0.56297 0.56297106 6.533553   2E−09 5284.001. NM_002644.2 AX012182.1 GENBANK_PATENT 1
1321 301.003.1-T_at −0.56291 0.56291408 6.532585   2E−09 301.003.1 NM_000700.1 CB124198.1 EST 1
1322 4240.007.1-F_at −0.5629 0.56290348 6.532405   2E−09 4240.007. NM_005928.1 CN485231.1 EST 1
1323 4240.007.1-B_at −0.56283 0.56283211 6.531193   2E−09 4240.007. NM_005928.1 CN485231.1 EST 1
1324 4781.015.2-D_at −0.56272 0.56272205 6.529324   2E−09 4781.015. NM_005596.1 DN995118.1 EST 1
1325 10124.001.1-T_at −0.56261 0.56260672 6.527366   2E−09 10124.001 NM_001037164. BX354322.2 EST 87
1326 57561.004.1-T_at −0.56258 0.56258399 6.52698   2E−09 57561.004 NM_020801.1 DB046772.1 EST 1
1327 29127.022.2-T_at 0.562515 0.56251532 6.525814   2E−09 29127.022 NM_013277.2 DB065206.1 EST 1
1328 10461.002.2-T_at −0.56243 0.56242806 6.524333   2E−09 10461.002 NM_006343.2 CQ725500.1 GENBANK_PATENT 1
1329 7168.039.1-B_at −0.56237 0.56236838 6.523321   2E−09 7168.039. NM_001018020. AA096317.1 EST 1
1330 90293.004.2-T_at −0.56231 0.56231454 6.522407   2E−09 90293.004 NM_033495.2 AL591986.1 mRNA 38
1331 1410.006.1-D_at −0.56207 0.56206646 6.518201   2E−09 1410.006. NM_001885.1 BF670917.1 EST 1
1332 7113.010.1-E_at −0.56205 0.56205065 6.517933   2E−09 7113.010. NM_005656.2 DA460061.1 EST 1
1333 8404.025.1-T_at −0.562 0.56200329 6.51713   2E−09 8404.025. NM_004684.2 DB086831.1 EST 1
1334 79971.008.1-T_at −0.56198 0.56198359 6.516796   2E−09 79971.008 NM_001002292. DA711278.1 EST 1
1335 4240.005.1-T_at −0.56194 0.5619438 6.516122   2E−09 4240.005. NM_005928.1 BX341151.2 EST 1
1336 10051.007.1-T_at 0.561888 0.56188758 6.515169   2E−09 10051.007 NM_001002799. CS161896.1 GENBANK_PATENT 13
1337 2.002.1-F_at −0.56186 0.56185527 6.514621   2E−09 2.002.1 NM_000014.4 CQ672194.1 GENBANK_PATENT 1
1338 29997.021.1-E_at −0.56185 0.56185259 6.514576   2E−09 29997.021 NM_015710.3 CN353870.1 EST 1
1339 1410.011.1-T_at −0.56169 0.56168682 6.511768   2E−09 1410.011. NM_001885.1 BI561839.1 EST 1
1340 4601.009.2-F_at −0.56154 0.5615434 6.509339   2E−09 4601.009. NM_130439.3 BE789186.1 EST 1
1341 1959.001.1-T_at −0.56154 0.56153623 6.509218   2E−09 1959.001. NM_000399.2 DB086600.1 EST 1
1342 2335.026.3-T_at 0.561472 0.56147179 6.508127   2E−09 2335.026. NM_212482.1 BX641150.1 mRNA 43
1343 55107.001.1-F_at −0.56145 0.56144879 6.507738   2E−09 55107.001 NM_018043.4 AY728143.1 mRNA 30
1344 1062.001.1-D_at 0.561342 0.56134161 6.505924   2E−09 1062.001. NM_001813.2 CQ715352.1 GENBANK_PATENT 1
1345 6876.002.1-B_at −0.56132 0.56132281 6.505606   2E−09 6876.002. NM_001001522. DB262921.1 EST 1
1346 358.018.1-D_at −0.56116 0.56116002 6.502851   2E−09 358.018.1 NM_198098.1 BI765065.1 EST 1
1347 4781.004.1-F_at −0.5611 0.56110421 6.501907   2E−09 4781.004. NM_005596.1 BG742798.1 EST 4
1348 8404.028.3-F_at −0.56107 0.56107051 6.501338   2E−09 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
1349 11130.004.1-T_at 0.561027 0.56102703 6.500602   2E−09 11130.004 NM_001005414. BQ065119.1 EST 1
1350 2568.002.2-B_at −0.56101 0.56100825 6.500285   2E−09 2568.002. NM_014211.1 DB235581.1 EST 1
1351 29089.004.1-T_at 0.560878 0.56087834 6.498089   2E−09 29089.004 NM_014176.1 AV727151.1 EST 1
1352 57685.005.1-B_at −0.5608 0.56079992 6.496763   2E−09 57685.005 NM_020925.1 CQ721664.1 GENBANK_PATENT 1
1353 7170.016.3-T_at 0.560753 0.56075324 6.495974   2E−09 7170.016. NM_153649.2 BF575596.1 EST 1
1354 10440.003.1-T_at 0.560736 0.56073635 6.495689   2E−09 10440.003 NM_006335.1 BG492850.1 EST 1
1355 2335.017.1-F_at 0.560696 0.56069643 6.495015   2E−09 2335.017. NM_212482.1 CQ896577.1 GENBANK_PATENT 4
1356 2.002.1-D_at −0.56056 0.56056211 6.492745   2E−09 2.002.1 NM_000014.4 CQ672194.1 GENBANK_PATENT 1
1357 9055.018.1-D_at 0.56056 0.56056001 6.49271   2E−09 9055.018. NM_003981.2 DA033856.1 EST 1
1358 64151.003.1-T_at 0.56055 0.56055011 6.492543   2E−09 64151.003 NM_022346.3 BG202075.1 EST 1
1359 59342.002.1-B_at −0.5605 0.56049557 6.491622   2E−09 59342.002 NM_021626.1 BP338281.1 EST 1
1360 7169.007.1-F_at −0.56034 0.56033824 6.488965   2E−09 7169.007. NM_213674.1 BQ923578.1 EST 67
1361 7170.026.1-C_at 0.560224 0.5602241 6.487039   2E−09 7170.026. NM_153649.2 BQ933569.1 EST 1
1362 667.010.1-B_at −0.56012 0.56011837 6.485255   2E−09 667.010.1 NM_183380.1 DA361412.1 EST 1
1363 4781.010.1-F_at −0.56006 0.56006097 6.484286   2E−09 4781.010. NM_005596.1 BX648845.1 mRNA 3
1364 10051.001.1-T_at 0.560051 0.56005099 6.484118   2E−09 10051.001 NM_001002799. BC106033.1 mRNA 52
1365 7113.004.1-C_at −0.56001 0.56001252 6.483469   2E−09 7113.004. NM_005656.2 CQ976405.1 GENBANK_PATENT 2
1366 140885.010.2-F −0.55988 0.55988455 6.481311   2E−09 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
1367 29997.019.1-F_at −0.55983 0.55982573 6.480319   2E−09 29997.019 NM_015710.3 BF771953.1 EST 1
1368 2335.013.1-T_at 0.559752 0.55975189 6.479074   2E−09 2335.013. NM_212482.1 AL551632.3 EST 2
1369 7170.017.1-D_at 0.55967 0.55967009 6.477696   2E−09 7170.017. NM_153649.2 BF574676.1 EST 1
1370 219972.004.1-F −0.55958 0.55957847 6.476152   2E−09 219972.00 XM_166227.6 DA946058.1 EST 1
1371 22974.010.1-E_at 0.559421 0.55942061 6.473493   2E−09 22974.010 NM_012112.4 DB096591.1 EST 1
1372 2982.011.1-T_at −0.55932 0.55932229 6.471837   2E−09 2982.011. NM_000856.2 BX649180.1 mRNA 10
1373 152015.005.1-F −0.55929 0.55929021 6.471297   2E−09 152015.00 NM_001012337. CQ732372.1 GENBANK_PATENT 1
1374 3914.001.1-C_at −0.5592 0.55919902 6.469761   2E−09 3914.001. NM_000228.2 CQ921791.1 GENBANK_PATENT 2
1375 7168.012.2-B_at −0.55912 0.55911961 6.468425   2E−09 7168.012. NM_001018020. AK129882.1 mRNA 2
1376 1938.024.1-C_at −0.55904 0.55903817 6.467054   2E−09 1938.024. NM_001961.3 BE747136.1 EST 1
1377 10051.004.1-T_at 0.559001 0.55900072 6.466424   2E−09 10051.004 NM_001002799. DB144219.1 EST 1
1378 2335.006.1-B_at 0.55897 0.55897034 6.465913   2E−09 2335.006. NM_212482.1 CX785805.1 EST 1
1379 57447.028.1-E_at −0.55892 0.55891938 6.465056   2E−09 57447.028 NM_201535.1 DA205446.1 EST 1
1380 2893.001.1-T_at −0.5589 0.55890095 6.464746   2E−09 2893.001. NM_000829.1 DA258118.1 EST 1
1381 4288.005.1-F_at 0.558883 0.55888308 6.464445   2E−09 4288.005. NM_002417.2 BM455229.1 EST 1
1382 2938.007.1-T_at −0.55888 0.55887858 6.464369   2E−09 2938.007. NM_145740.2 AX477713.1 GENBANK_PATENT 1
1383 29127.020.1-T_at 0.558848 0.55884819 6.463858   2E−09 29127.020 NM_013277.2 DB089267.1 EST 1
1384 154810.002.1-T −0.55861 0.55861375 6.459916   2E−09 154810.00 NM_130847.1 AX886249.1 GENBANK_PATENT 1
1385 9232.001.1-T_at 0.558605 0.55860527 6.459774   2E−09 9232.001. NM_004219.2 CN285866.1 EST 1
1386 55214.004.1-T_at −0.55803 0.55802814 6.450079   3E−09 55214.004 NM_018192.2 DA953365.1 EST 1
1387 79971.002.1-B_at −0.55798 0.5579779 6.449236   3E−09 79971.002 NM_001002292. CQ720425.1 GENBANK_PATENT 1
1388 3977.002.1-T_at −0.55793 0.55793279 6.448479   3E−09 3977.002. NM_002310.3 DR005799.1 EST 1
1389 7170.028.1-F_at 0.557857 0.5578569 6.447206   3E−09 7170.028. NM_153649.2 BQ220396.1 EST 2
1390 1410.009.1-E_at −0.55785 0.55784993 6.447089   3E−09 1410.009. NM_001885.1 BQ437433.1 EST 2
1391 4781.004.1-T_at −0.55762 0.55762387 6.443297   3E−09 4781.004. NM_005596.1 BG742798.1 EST 4
1392 9413.002.2-T_at −0.55755 0.5575481 6.442026   3E−09 9413.002. NM_004816.2 AW779892.1 EST 1
1393 25925.005.1-T_at −0.55744 0.55744483 6.440295   3E−09 25925.005 NM_015461.1 DB285938.1 EST 1
1394 55366.002.1-T_at −0.55743 0.55743398 6.440113   3E−09 55366.002 NM_018490.1 BC033039.2 mRNA 3
1395 6288.001.1-E_at −0.55742 0.55742086 6.439893   3E−09 6288.001. NM_199161.1 AX899121.1 GENBANK_PATENT 2
1396 2335.025.2-C_at 0.557411 0.55741092 6.439727   3E−09 2335.025. NM_212482.1 CQ715726.1 GENBANK_PATENT 3
1397 2335.004.1-F_at 0.557345 0.55734468 6.438616   3E−09 2335.004. NM_212482.1 AU139388.1 EST 1
1398 7170.038.1-F_at 0.557344 0.55734423 6.438609   3E−09 7170.038. NM_153649.2 BG425254.1 EST 2
1399 7373.003.3-B_at −0.55728 0.55728249 6.437574   3E−09 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
1400 5744.003.2-B_at −0.55713 0.55713472 6.435099   3E−09 5744.003. NM_198965.1 BG680355.1 EST 1
1401 1164.001.1-F_at 0.556978 0.5569777 6.432469   3E−09 1164.001. NM_001827.1 AX971617.1 GENBANK_PATENT 1
1402 23266.005.1-T_at −0.55685 0.55685184 6.430362   3E−09 23266.005 NM_012302.2 DA764511.1 EST 1
1403 4601.015.2-F_at −0.55673 0.55673111 6.428342   3E−09 4601.015. NM_130439.3 DA279837.1 EST 1
1404 23092.009.1-D_at −0.55669 0.55668653 6.427596   3E−09 23092.009 NM_015071.2 BM045740.1 EST 1
1405 83699.004.1-T_at −0.55668 0.55667613 6.427422   3E−09 83699.004 NM_031469.1 AX980231.1 GENBANK_PATENT 1
1406 2982.013.1-T_at −0.55666 0.55665713 6.427104   3E−09 2982.013. NM_000856.2 CF594362.1 EST 1
1407 26289.013.1-F_at −0.55662 0.55662356 6.426543   3E−09 26289.013 NM_174858.1 CK024190.1 EST 1
1408 7113.003.1-F_at −0.55657 0.5565676 6.425607   3E−09 7113.003. NM_005656.2 CQ976404.1 GENBANK_PATENT 2
1409 390.003.1-T_at −0.55648 0.55648155 6.424167   3E−09 390.003.1 NM_005168.3 DA532407.1 EST 1
1410 6304.002.2-T_at −0.55641 0.55641323 6.423025   3E−09 6304.002. NM_002971.2 BC001744.1 mRNA 33
1411 6304.009.2-T_at −0.55633 0.55633335 6.42169   3E−09 6304.009. NM_002971.2 DA497369.1 EST 1
1412 3872.017.1-T_at −0.55631 0.55631309 6.421351   3E−09 3872.017. NM_000422.1 BX378477.2 EST 1
1413 2335.013.1-D_at 0.556298 0.55629818 6.421102   3E−09 2335.013. NM_212482.1 AL551632.3 EST 2
1414 6790.001.1-T_at 0.556293 0.55629311 6.421017   3E−09 6790.001. NM_198436.1 D84212.1 mRNA 8
1415 51201.007.1-B_at −0.55615 0.55614867 6.418603   3E−09 51201.007 NM_016353.2 BF541714.1 EST 1
1416 54443.009.1-T_at 0.55614 0.5561397 6.418453   3E−09 54443.009 NM_018685.2 DA242046.1 EST 1
1417 54443.012.1-F_at 0.556003 0.55600288 6.416167   3E−09 54443.012 NM_018685.2 BG167656.1 EST 1
1418 5608.003.1-D_at −0.55592 0.55592463 6.41486   3E−09 5608.003. NM_002758.2 BP220368.1 EST 1
1419 2.005.1-B_at −0.55591 0.55590928 6.414604   3E−09 2.005.1 NM_000014.4 BI493707.1 EST 1
1420 23015.010.2-F_at −0.55591 0.55590628 6.414554   3E−09 23015.010 NM_181076.2 XM_497449.1 REFSEQ 1
1421 25925.010.1-T_at −0.55586 0.55585644 6.413722   3E−09 25925.010 NM_015461.1 DA215395.1 EST 1
1422 79745.002.2-T_at −0.55584 0.55584433 6.413519   3E−09 79745.002 NM_024692.3 DB034631.1 EST 2
1423 23650.007.1-E_at −0.55581 0.55580568 6.412874   3E−09 23650.007 NM_058193.1 BX395679.2 EST 1
1424 953.013.1-B_at −0.55579 0.55578981 6.412609   3E−09 953.013.1 NM_001776.3 CQ721824.1 GENBANK_PATENT 1
1425 7153.002.5-C_at 0.555743 0.55574323 6.411832   3E−09 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
1426 4240.001.1-T_at −0.55574 0.55573744 6.411735   3E−09 4240.001. NM_005928.1 BF525404.1 EST 1
1427 58499.005.1-T_at −0.55571 0.55571242 6.411317   3E−09 58499.005 NM_021224.3 BI461756.1 EST 1
1428 7168.026.1-C_at −0.55559 0.55558982 6.409271   3E−09 7168.026. NM_001018020. CV810859.1 EST 1
1429 8404.026.1-T_at −0.55558 0.55558292 6.409156   3E−09 8404.026. NM_004684.2 BX647713.1 mRNA 141
1430 94274.002.1-D_at −0.55557 0.55557226 6.408978   3E−09 94274.002 NM_033256.1 CQ730829.1 GENBANK_PATENT 1
1431 301.008.1-C_at −0.55554 0.55553521 6.40836   3E−09 301.008.1 NM_000700.1 CD688703.1 EST 1
1432 3426.001.1-C_at −0.55549 0.55548513 6.407525   3E−09 3426.001. NM_000204.1 BC020718.1 mRNA 165
1433 2938.007.2-B_at −0.55543 0.55543318 6.406658   3E−09 2938.007. NM_145740.2 AX477713.1 GENBANK_PATENT 1
1434 7373.003.5-C_at −0.55538 0.55537917 6.405757   3E−09 7373.003. NM_021110.1 CQ716670.1 GENBANK_PATENT 1
1435 7169.001.2-F_at −0.55536 0.55535866 6.405415   3E−09 7169.001. NM_213674.1 BM809268.1 EST 4
1436 2119.007.1-F_at −0.55522 0.5552225 6.403145   3E−09 2119.007. NM_004454.1 BE408130.1 EST 1
1437 1959.001.2-T_at −0.55498 0.55498357 6.399162   3E−09 1959.001. NM_000399.2 DB086600.1 EST 1
1438 9824.006.1-T_at 0.55476 0.55475962 6.395432   3E−09 9824.006. NM_014783.2 CK903028.1 EST 2
1439 301.013.1-B_at −0.55475 0.55475105 6.395289   3E−09 301.013.1 NM_000700.1 BF130804.1 EST 1
1440 10124.004.1-B_at −0.55458 0.55458304 6.392491   3E−09 10124.004 NM_001037164. BU661374.1 EST 12
1441 140885.010.3-F −0.55438 0.55438483 6.389193   3E−09 140885.01 NM_080792.2 CQ728313.1 GENBANK_PATENT 1
1442 54443.012.1-B_at 0.554381 0.5543815 6.389137   3E−09 54443.012 NM_018685.2 BG167656.1 EST 1
1443 29997.008.1-F_at −0.55437 0.554365 6.388863   3E−09 29997.008 NM_015710.3 BI871613.1 EST 1
1444 23092.002.1-T_at −0.55436 0.55435963 6.388774   3E−09 23092.002 NM_015071.2 CQ732129.1 GENBANK_PATENT 1
1445 1308.009.1-E_at −0.55427 0.55427197 6.387315   3E−09 1308.009. NM_130778.1 DA425187.1 EST 1
1446 1308.004.1-C_at −0.55418 0.55418499 6.385868   3E−09 1308.004. NM_130778.1 BE615666.1 EST 1
1447 59342.003.1-B_at −0.55416 0.55416164 6.38548   3E−09 59342.003 NM_021626.1 DA821057.1 EST 1
1448 2119.006.1-F_at −0.55414 0.55413804 6.385088   3E−09 2119.006. NM_004454.1 DB094869.1 EST 1
1449 6304.011.2-T_at −0.55412 0.55411832 6.38476   3E−09 6304.011. NM_002971.2 BP359118.1 EST 1
1450 4288.006.2-D_at 0.553943 0.5539433 6.38185   3E−09 4288.006. NM_002417.2 BP363635.1 EST 1
1451 358.017.1-D_at −0.55393 0.5539341 6.381697   3E−09 358.017.1 NM_198098.1 AY312580.1 mRNA 1
1452 29994.009.1-D_at −0.55389 0.55388615 6.380901   4E−09 29994.009 NM_013450.1 DA218896.1 EST 1
1453 23650.006.1-T_at −0.55388 0.55387924 6.380786   4E−09 23650.006 NM_058193.1 BE304682.1 EST 1
1454 3945.024.1-T_at −0.5538 0.55379733 6.379425   4E−09 3945.024. NM_002300.3 BF127786.1 EST 1
1455 9073.003.1-T_at −0.55367 0.55367412 6.377378   4E−09 9073.003. NM_199328.1 BP276390.1 EST 1
1456 55165.004.1-B_at 0.553669 0.55366932 6.377298   4E−09 55165.004 NM_018131.3 BX416068.2 EST 1
1457 54928.003.1-C_at −0.55352 0.55352466 6.374896   4E−09 54928.003 NM_017813.2 DB283344.1 EST 1
1458 489.006.1-C_at −0.55341 0.55340971 6.372987   4E−09 489.006.1 NM_174958.1 CV379840.1 EST 1
1459 6122.030.1-T_at −0.55337 0.55337311 6.37238   4E−09 6122.030. NM_000967.3 BF315041.1 EST 1
1460 4781.014.2-T_at −0.55315 0.55315167 6.368705   4E−09 4781.014. NM_005596.1 DN918235.1 EST 1
1461 7168.014.3-B_at −0.55307 0.55307042 6.367357   4E−09 7168.014. NM_001018020. BP257563.1 EST 1
1462 4147.003.1-F_at −0.55281 0.55280885 6.36302   4E−09 4147.003. NM_002380.3 AY358895.1 mRNA 81
1463 57451.001.3-B_at −0.55273 0.55273245 6.361754   4E−09 57451.001 XM_931456.1 CS188752.1 GENBANK_PATENT 1
1464 9055.018.1-T_at 0.552521 0.55252074 6.358246   4E−09 9055.018. NM_003981.2 DA033856.1 EST 1
1465 4931.013.1-T_at 0.552443 0.552443 6.356958   4E−09 4931.013. NM_002533.2 BG771162.1 EST 1
1466 7169.001.1-T_at −0.55242 0.55241607 6.356513   4E−09 7169.001. NM_213674.1 BM809268.1 EST 4
1467 2568.005.1-B_at −0.55241 0.55241426 6.356483   4E−09 2568.005. NM_014211.1 AK055205.1 mRNA 11
1468 4435.001.1-T_at −0.5524 0.55240125 6.356267   4E−09 4435.001. NM_004143.2 AA317379.1 EST 1
1469 2335.006.1-F_at 0.552355 0.55235498 6.355501   4E−09 2335.006. NM_212482.1 CX785805.1 EST 1
1470 55294.007.1-T_at −0.55234 0.55234085 6.355267   4E−09 55294.007 NM_033632.2 BF380630.1 EST 1
1471 4288.006.2-B_at 0.55233 0.55233026 6.355092   4E−09 4288.006. NM_002417.2 BP363635.1 EST 1
1472 29089.003.1-F_at 0.552316 0.55231581 6.354852   4E−09 29089.003 NM_014176.1 AV740591.1 EST 1
1473 2335.032.1-F_at 0.55229 0.55228962 6.354419   4E−09 2335.032. NM_212482.1 DA647475.1 EST 1
1474 57162.003.1-T_at −0.55221 0.55220544 6.353025   4E−09 57162.003 NM_020651.2 BX380539.2 EST 3
1475 4288.005.1-B_at 0.552168 0.5521684 6.352412   4E−09 4288.005. NM_002417.2 BM455229.1 EST 1
1476 3860.004.1-T_at −0.55215 0.5521477 6.35207   4E−09 3860.004. NM_153490.1 DA763721.1 EST 1
1477 2.018.1-F_at −0.55206 0.55205696 6.350568   4E−09 2.018.1 NM_000014.4 DB090657.1 EST 1
1478 23015.010.2-C_at −0.55198 0.55198079 6.349308   4E−09 23015.010 NM_181076.2 XM_497449.1 REFSEQ 1
1479 6122.029.1-F_at −0.55188 0.55188275 6.347686   4E−09 6122.029. NM_000967.3 BG547902.1 EST 1
1480 7113.007.1-E_at −0.55181 0.55181118 6.346503   4E−09 7113.007. NM_005656.2 DR005196.1 EST 1
1481 2982.001.1-T_at −0.55178 0.55177855 6.345963   4E−09 2982.001. NM_000856.2 DA793192.1 EST 1
1482 56999.003.1-C_at −0.55176 0.55175685 6.345604   4E−09 56999.003 NM_182920.1 CQ721254.1 GENBANK_PATENT 1
1483 152015.005.1-B −0.55166 0.55165647 6.343945   4E−09 152015.00 NM_001012337. CQ732372.1 GENBANK_PATENT 1
1484 1410.002.1-T_at −0.55165 0.55165464 6.343914   4E−09 1410.002. NM_001885.1 AX899073.1 GENBANK_PATENT 4
1485 7373.004.1-B_at −0.55161 0.55160828 6.343148   4E−09 7373.004. NM_021110.1 M64109.1 mRNA 1
1486 492304.010.1-T −0.5516 0.55160004 6.343012   4E−09 492304.01 — — — —
1487 80034.003.2-T_at −0.55149 0.55148932 6.341182   4E−09 80034.003 NM_024969.2 CQ733306.1 GENBANK_PATENT 1
1488 4281.009.1-F_at −0.55134 0.55133895 6.338698   4E−09 4281.009. NM_033290.1 AY540014.1 mRNA 1
1489 301.011.1-B_at −0.5513 0.55130021 6.338058   4E−09 301.011.1 NM_000700.1 BG435248.1 EST 1
1490 90293.002.2-T_at −0.55112 0.55112335 6.335138   4E−09 90293.002 NM_033495.2 BP360232.1 EST 1
1491 800.013.1-C_at −0.55112 0.55112102 6.335099   4E−09 800.013.1 NM_033138.2 NM_033157.2 REFSEQ 151
1492 142.011.1-T_at 0.550921 0.55092062 6.331791   4E−09 142.011.1 NM_001618.2 DA757025.1 EST 1
1493 6876.017.1-T_at −0.55079 0.55078992 6.329635   4E−09 6876.017. NM_001001522. BX428130.2 EST 1
1494 825.021.1-D_at −0.55076 0.55076446 6.329215   4E−09 825.021.1 NM_212464.1 AV645796.1 EST 1
1495 714.002.1-F_at −0.5507 0.55069829 6.328124   4E−09 714.002.1 NM_172369.2 AX894785.1 GENBANK_PATENT 1
1496 2335.039.1-C_at 0.550688 0.55068782 6.327951   4E−09 2335.039. NM_212482.1 BP288118.1 EST 1
1497 2.024.2-D_at −0.55068 0.55068374 6.327884   4E−09 2.024.2 NM_000014.4 DB286897.1 EST 1
1498 9037.004.2-T_at −0.55067 0.55066904 6.327641   4E−09 9037.004. NM_003966.1 BF923022.1 EST 1
1499 4781.006.2-D_at −0.55052 0.55051889 6.325165   5E−09 4781.006. NM_005596.1 AK131233.1 mRNA 2
1500 4601.012.1-T_at −0.55051 0.55051321 6.325072   5E−09 4601.012. NM_130439.3 DA746301.1 EST 1
1501 4781.009.2-B_at −0.55048 0.55048372 6.324586   5E−09 4781.009. NM_005596.1 CQ732556.1 GENBANK_PATENT 1
1502 7169.004.1-F_at −0.55041 0.55041381 6.323433   5E−09 7169.004. NM_213674.1 BG027526.1 EST 1
1503 54443.010.1-C_at 0.550402 0.55040232 6.323244   5E−09 54443.010 NM_018685.2 DA196444.1 EST 1
1504 7818.023.1-F_at 0.550382 0.55038162 6.322903   5E−09 7818.023. NM_004632.2 BQ424083.1 EST 1
1505 79971.009.2-T_at −0.55036 0.5503562 6.322484   5E−09 79971.009 NM_001002292. DA264864.1 EST 1
1506 4601.007.1-T_at −0.55036 0.5503552 6.322467   5E−09 4601.007. NM_130439.3 DA009519.1 EST 1
1507 7113.011.2-D_at −0.55032 0.55031657 6.321831   5E−09 7113.011. NM_005656.2 DA868984.1 EST 1
1508 54443.008.1-B_at 0.550158 0.5501582 6.319222   5E−09 54443.008 NM_018685.2 DB172145.1 EST 1
1509 23092.009.2-D_at −0.55009 0.5500931 6.318149   5E−09 23092.009 NM_015071.2 BM045740.1 EST 1
1510 57447.006.1-E_at −0.55005 0.55004557 6.317367   5E−09 57447.006 NM_201535.1 DA283861.1 EST 4
1511 7170.035.2-B_at 0.549889 0.54988872 6.314784   5E−09 7170.035. NM_153649.2 BF575164.1 EST 1
1512 79971.010.1-T_at −0.54986 0.54986373 6.314373   5E−09 79971.010 NM_001002292. CB268343.1 EST 1
1513 4288.004.1-T_at 0.549863 0.54986337 6.314367   5E−09 4288.004. NM_002417.2 BP232141.1 EST 1
1514 59342.006.1-T_at −0.54953 0.54953056 6.308891   5E−09 59342.006 NM_021626.1 BP196952.1 EST 1
1515 4781.017.1-T_at −0.54938 0.54938028 6.30642   5E−09 4781.017. NM_005596.1 DR002043.1 EST 1
1516 4781.013.2-B_at −0.54937 0.54936792 6.306216   5E−09 4781.013. NM_005596.1 DA750893.1 EST 1
1517 23015.010.3-E_at −0.54933 0.54932704 6.305544   5E−09 23015.010 NM_181076.2 XM_497449.1 REFSEQ 1
1518 9055.013.1-B_at 0.548993 0.54899327 6.30006   5E−09 9055.013. NM_003981.2 CN348395.1 EST 1
1519 5621.003.1-T_at −0.54894 0.54894022 6.299188   5E−09 5621.003. NM_000311.2 BP218622.1 EST 1
1520 2893.006.1-T_at −0.5488 0.54880253 6.296927   5E−09 2893.006. NM_000829.1 BF669210.1 EST 1
1521 3161.007.1-F_at 0.548622 0.54862189 6.293962   5E−09 3161.007. NM_012484.1 BG198860.1 EST 1
1522 55107.001.1-T_at −0.54841 0.548412 6.290518   5E−09 55107.001 NM_018043.4 AY728143.1 mRNA 30
1523 2327.002.1-C_at −0.54819 0.54819208 6.286911   5E−09 2327.002. NM_001460.2 CD684429.1 EST 1
1524 3945.014.1-B_at −0.54812 0.54812393 6.285794   5E−09 3945.014. NM_002300.3 BG402389.1 EST 1
1525 151438.003.1-C −0.54801 0.54801484 6.284006   5E−09 151438.00 AK055877.1 DB124570.1 EST 2
1526 7113.013.1-E_at −0.54795 0.54795303 6.282993   5E−09 7113.013. NM_005656.2 DA627080.1 EST 1
1527 441417.001.1-B −0.54784 0.54783722 6.281095   5E−09 441417.00 XM_497039.2 XM_933326.1 REFSEQ 3
1528 2982.012.1-F_at −0.54781 0.54781217 6.280685   6E−09 2982.012. NM_000856.2 BC012627.1 mRNA 2
1529 7168.005.3-E_at −0.54767 0.54766942 6.278347   6E−09 7168.005. NM_001018020. BP373012.1 EST 1
1530 27338.001.1-B_at 0.547668 0.54766773 6.27832   6E−09 27338.001 NM_014501.1 BI198504.1 EST 3
1531 8404.028.1-B_at −0.54766 0.54766289 6.27824   6E−09 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
1532 4601.019.1-F_at −0.54764 0.54764478 6.277944   6E−09 4601.019. NM_130439.3 BQ425277.1 EST 1
1533 8404.008.1-B_at −0.54752 0.54751598 6.275835   6E−09 8404.008. NM_004684.2 DA342341.1 EST 1
1534 23266.008.3-F_at −0.54739 0.54739477 6.273851   6E−09 23266.008 NM_012302.2 CQ799210.1 GENBANK_PATENT 1
1535 4931.012.1-F_at 0.547302 0.54730211 6.272335   6E−09 4931.012. NM_002533.2 BQ930348.1 EST 1
1536 10010.007.1-E_at −0.54712 0.54711818 6.269326   6E−09 10010.007 NM_004180.2 AI525053.1 EST 1
1537 11065.003.1-B_at 0.54698 0.54697977 6.267063   6E−09 11065.003 NM_181802.1 CS138819.1 GENBANK_PATENT 5
1538 3925.016.1-C_at 0.546859 0.5468594 6.265095   6E−09 3925.016. NM_203399.1 BE888426.1 EST 1
1539 7170.017.1-C_at 0.546805 0.54680477 6.264203   6E−09 7170.017. NM_153649.2 BF574676.1 EST 1
1540 301.011.1-F_at −0.54668 0.54668114 6.262183   6E−09 301.011.1 NM_000700.1 BG435248.1 EST 1
1541 57685.005.2-T_at −0.54663 0.54663145 6.261371   6E−09 57685.005 NM_020925.1 CQ721664.1 GENBANK_PATENT 1
1542 23015.014.1-T_at −0.54659 0.54658979 6.26069   6E−09 23015.014 NM_181076.2 DA928720.1 EST 1
1543 7153.002.3-T_at 0.546559 0.54655896 6.260187   6E−09 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
1544 2568.005.2-D_at −0.5465 0.5464996 6.259217   6E−09 2568.005. NM_014211.1 AK055205.1 mRNA 11
1545 2335.039.1-F_at 0.546413 0.5464132 6.257806   6E−09 2335.039. NM_212482.1 BP288118.1 EST 1
1546 10124.002.1-F_at −0.5464 0.54640453 6.257665   6E−09 10124.002 NM_001037164. BG178114.1 EST 6
1547 283299.003.1-D −0.5461 0.54610398 6.252759   6E−09 283299.00 XM_498506.1 XM_932188.1 REFSEQ 1
1548 4781.013.1-T_at −0.54585 0.54585341 6.248672   6E−09 4781.013. NM_005596.1 DA750893.1 EST 1
1549 7170.012.2-D_at 0.545774 0.545774 6.247378   6E−09 7170.012. NM_153649.2 DA893534.1 EST 1
1550 667.014.1-T_at −0.54573 0.54572906 6.246645   6E−09 667.014.1 NM_183380.1 CQ851391.1 GENBANK_PATENT 1
1551 4781.009.2-D_at −0.54569 0.54568951 6.246   6E−09 4781.009. NM_005596.1 CQ732556.1 GENBANK_PATENT 1
1552 7169.001.1-D_at −0.54565 0.54565203 6.24539   6E−09 7169.001. NM_213674.1 BM809268.1 EST 4
1553 2161.001.1-T_at 0.545644 0.54564352 6.245251   6E−09 2161.001. NM_000505.2 AX147449.1 GENBANK_PATENT 30
1554 1308.001.1-F_at −0.5456 0.54560226 6.244578   6E−09 1308.001. NM_130778.1 BM773425.1 EST 1
1555 7168.012.2-D_at −0.54541 0.54540889 6.241428   7E−09 7168.012. NM_001018020. AK129882.1 mRNA 2
1556 10010.004.1-E_at −0.54541 0.54540884 6.241427   7E−09 10010.004 NM_004180.2 BM750784.1 EST 1
1557 54443.009.1-D_at 0.545394 0.54539371 6.241181   7E−09 54443.009 NM_018685.2 DA242046.1 EST 1
1558 7039.002.1-D_at −0.54538 0.54537813 6.240927   7E−09 7039.002. NM_003236.1 AF149096.1 mRNA 2
1559 57447.041.1-B_at −0.54524 0.54523712 6.23863   7E−09 57447.041 NM_201535.1 DA295124.1 EST 1
1560 4281.007.1-B_at −0.54521 0.54521491 6.238269   7E−09 4281.007. NM_033290.1 AY540023.1 mRNA 2
1561 301.009.1-T_at −0.54517 0.54516544 6.237463   7E−09 301.009.1 NM_000700.1 CD357777.1 EST 2
1562 9055.014.1-F_at 0.545101 0.54510063 6.236408   7E−09 9055.014. NM_003981.2 BE300335.1 EST 1
1563 79971.013.1-T_at −0.54495 0.54494911 6.233942   7E−09 79971.013 NM_001002292. DA878291.1 EST 1
1564 11065.003.2-T_at 0.544945 0.5449453 6.23388   7E−09 11065.003 NM_181802.1 CS138819.1 GENBANK_PATENT 5
1565 7113.009.1-E_at −0.54493 0.54493426 6.233701   7E−09 7113.009. NM_005656.2 DA873416.1 EST 1
1566 51203.002.2-T_at 0.544867 0.54486653 6.232599   7E−09 51203.002 NM_016359.2 AL561514.3 EST 1
1567 7170.006.1-B_at 0.54486 0.54486029 6.232497   7E−09 7170.006. NM_153649.2 DB003864.1 EST 1
1568 80034.002.1-T_at −0.54484 0.54484345 6.232223   7E−09 80034.002 NM_024969.2 DA769284.1 EST 1
1569 1345.012.1-D_at 0.544806 0.54480624 6.231618   7E−09 1345.012. NM_004374.2 DB564533.1 EST 1
1570 8321.004.1-T_at −0.54478 0.54477916 6.231178   7E−09 8321.004. NM_003505.1 AA249884.1 EST 1
1571 10461.001.1-T_at −0.54469 0.54468608 6.229664   7E−09 10461.001 NM_006343.2 CQ760423.1 GENBANK_PATENT 4
1572 4601.010.1-T_at −0.54466 0.54466418 6.229308   7E−09 4601.010. NM_130439.3 CS031066.1 GENBANK_PATENT 3
1573 3709.004.1-E_at −0.54444 0.54444277 6.225708   7E−09 3709.004. NM_002223.1 BP364657.1 EST 1
1574 4781.017.2-T_at −0.5444 0.54440035 6.225019   7E−09 4781.017. NM_005596.1 DR002043.1 EST 1
1575 5621.010.1-B_at −0.54431 0.54431029 6.223555   7E−09 5621.010. NM_000311.2 DA174560.1 EST 1
1576 54763.001.1-T_at −0.54431 0.54430594 6.223485   7E−09 54763.001 NM_017578.2 BI465233.1 EST 4
1577 306.003.1-B_at −0.54429 0.54428587 6.223159   7E−09 306.003.1 NM_005139.1 CQ721707.1 GENBANK_PATENT 1
1578 2335.035.1-C_at 0.544238 0.54423813 6.222383   7E−09 2335.035. NM_212482.1 CX755647.1 EST 1
1579 4601.015.1-T_at −0.54414 0.54413917 6.220776   7E−09 4601.015. NM_130439.3 DA279837.1 EST 1
1580 7168.038.1-D_at −0.54409 0.54408836 6.219951   7E−09 7168.038. NM_001018020. AK092573.1 mRNA 5
1581 55732.003.1-T_at 0.543852 0.54385205 6.216114   7E−09 55732.003 NM_018186.2 DA733233.1 EST 2
1582 23266.001.1-T_at −0.54381 0.54380864 6.21541   7E−09 23266.001 NM_012302.2 AK123422.1 mRNA 2
1583 4288.006.2-E_at 0.543777 0.54377742 6.214903   7E−09 4288.006. NM_002417.2 BP363635.1 EST 1
1584 4781.013.2-D_at −0.54375 0.54374747 6.214417   7E−09 4781.013. NM_005596.1 DA750893.1 EST 1
1585 259266.001.1-B 0.543672 0.54367202 6.213193   7E−09 259266.00 NM_018136.2 BC034607.1 mRNA 7
1586 7170.029.1-F_at 0.543574 0.54357435 6.211608   8E−09 7170.029. NM_153649.2 BM011010.1 EST 1
1587 51201.007.1-T_at −0.54346 0.5434567 6.2097   8E−09 51201.007 NM_016353.2 BF541714.1 EST 1
1588 7169.002.1-F_at −0.54328 0.54327991 6.206834   8E−09 7169.002. NM_213674.1 AL555921.3 EST 1
1589 8404.028.1-T_at −0.54323 0.5432313 6.206046   8E−09 8404.028. NM_004684.2 CQ727530.1 GENBANK_PATENT 1
1590 4781.015.1-T_at −0.54315 0.54314788 6.204695   8E−09 4781.015. NM_005596.1 DN995118.1 EST 1
1591 9055.012.1-T_at 0.543077 0.54307679 6.203543   8E−09 9055.012. NM_003981.2 BE298728.1 EST 1
1592 2893.004.1-T_at −0.5429 0.54289557 6.200607   8E−09 2893.004. NM_000829.1 DA066848.1 EST 1
1593 91653.015.1-T_at −0.54284 0.54283984 6.199705   8E−09 91653.015 NM_033254.2 R75666.1 EST 1
1594 10010.001.1-T_at −0.54281 0.54280637 6.199163   8E−09 10010.001 NM_004180.2 DA670701.1 EST 6
1595 1410.003.2-T_at −0.54281 0.54280581 6.199154   8E−09 1410.003. NM_001885.1 AX899079.1 GENBANK_PATENT 1
1596 6595.013.1-B_at −0.54268 0.54268082 6.19713   8E−09 6595.013. NM_003070.3 DA825858.1 EST 1
1597 4601.009.1-T_at −0.54264 0.54264498 6.19655   8E−09 4601.009. NM_130439.3 BE789186.1 EST 1
1598 23015.009.1-E_at −0.54245 0.5424498 6.193392   8E−09 23015.009 NM_181076.2 CA943083.1 EST 1
1599 2335.024.1-T_at 0.542425 0.54242468 6.192986   8E−09 2335.024. NM_212482.1 CQ731573.1 GENBANK_PATENT 1
1600 23650.009.1-F_at −0.54242 0.54242338 6.192965   8E−09 23650.009 NM_058193.1 BF836741.1 EST 1
1601 11254.001.1-F_at −0.54238 0.54237719 6.192217   8E−09 11254.001 NM_007231.1 BE819593.1 EST 1
1602 7286.002.1-T_at 0.542342 0.5423416 6.191642   8E−09 7286.002. NM_020127.1 BP315579.1 EST 1
1603 4931.004.1-T_at 0.54224 0.54223963 6.189993   8E−09 4931.004. NM_002533.2 BM693264.1 EST 1
1604 7113.005.1-E_at −0.54224 0.5422385 6.189974   8E−09 7113.005. NM_005656.2 DA865300.1 EST 1
1605 150572.004.1-F −0.54223 0.54222998 6.189837   8E−09 150572.00 NM_198274.2 BF790590.1 EST 1
1606 57447.002.1-C_at −0.54216 0.54215776 6.188669   8E−09 57447.002 NM_201535.1 BF526188.1 EST 1
1607 1410.002.2-T_at −0.54199 0.54198899 6.185941   8E−09 1410.002. NM_001885.1 AX899073.1 GENBANK_PATENT 4
1608 4316.001.1-F_at −0.54197 0.54197342 6.185689   8E−09 4316.001. NM_002423.3 CQ733055.1 GENBANK_PATENT 1
1609 254042.002.1-E −0.54193 0.54192668 6.184934   8E−09 254042.00 NM_199227.1 AX188221.1 GENBANK_PATENT 7
1610 79971.006.2-B_at −0.54193 0.54192511 6.184909   8E−09 79971.006 NM_001002292. DA048370.1 EST 1
1611 1396.001.1-T_at 0.54189 0.54189009 6.184343   8E−09 1396.001. NM_001311.3 N46592.1 EST 2
1612 7153.002.3-D_at 0.541626 0.54162631 6.180082   9E−09 7153.002. NM_001067.2 CQ735949.1 GENBANK_PATENT 114
1613 54443.001.1-F_at 0.541435 0.54143463 6.176988   9E−09 54443.001 NM_018685.2 BC070066.1 mRNA 10
1614 142.012.1-F_at 0.541335 0.54133459 6.175374   9E−09 142.012.1 NM_001618.2 BG900662.1 EST 1
1615 301.013.1-F_at −0.54115 0.54115484 6.172474   9E−09 301.013.1 NM_000700.1 BF130804.1 EST 1
1616 152015.004.1-E −0.54097 0.54096565 6.169423   9E−09 152015.00 NM_001012337. BC015413.1 mRNA 2
1617 8857.001.1-F_at −0.54089 0.54089094 6.168218   9E−09 8857.001. NM_003890.1 CQ730859.1 GENBANK_PATENT 1
1618 6203.002.1-B_at −0.54088 0.54087544 6.167968   9E−09 6203.002. NM_001013.3 AX969894.1 GENBANK_PATENT 1
1619 7168.010.1-D_at −0.54079 0.54078858 6.166568   9E−09 7168.010. NM_001018020. CD556048.1 EST 1
1620 57447.051.2-C_at −0.54076 0.54076391 6.166171   9E−09 57447.051 NM_201535.1 BX460053.2 EST 1
1621 4288.006.1-T_at 0.540756 0.54075554 6.166036   9E−09 4288.006. NM_002417.2 BP363635.1 EST 1
1622 54443.013.1-T_at 0.54066 0.54065959 6.16449   9E−09 54443.013 NM_018685.2 BX410228.2 EST 1
1623 9055.017.1-E_at 0.540557 0.54055744 6.162844   9E−09 9055.017. NM_003981.2 DB031145.1 EST 1
1624 55732.004.1-T_at 0.540487 0.54048721 6.161713   9E−09 55732.004 NM_018186.2 BF216714.1 EST 1
1625 9413.003.2-F_at −0.54047 0.5404689 6.161418   9E−09 9413.003. NM_004816.2 BX641153.1 mRNA 10
1626 4629.015.1-B_at −0.54046 0.5404569 6.161225   9E−09 4629.015. NM_022844.1 DB284318.1 EST 1
1627 84766.002.2-C_at −0.54045 0.54045424 6.161182   9E−09 84766.002 NM_032680.2 XM_498532.1 REFSEQ 1
1628 11065.008.1-T_at 0.540347 0.5403468 6.159452   9E−09 11065.008 NM_181802.1 NM_181800.1 REFSEQ 5
1629 81704.013.8-F_at −0.54034 0.5403434 6.159398   9E−09 81704.013 NM_203447.1 CQ723361.1 GENBANK_PATENT 1
1630 667.016.1-T_at −0.54033 0.54032607 6.159119   9E−09 667.016.1 NM_183380.1 DB013737.1 EST 1
1631 29997.004.1-F_at −0.5403 0.54030048 6.158707   1E−08 29997.004 NM_015710.3 BU154441.1 EST 1
1632 2824.001.3-B_at −0.5403 0.54029788 6.158665   1E−08 2824.001. NM_001001994. CQ717842.1 GENBANK_PATENT 1
1633 57447.004.1-B_at −0.54026 0.54025744 6.158014   1E−08 57447.004 NM_201535.1 CD515320.1 EST 2
1634 2982.003.1-T_at −0.54014 0.54014125 6.156144   1E−08 2982.003. NM_000856.2 DB179470.1 EST 1
1635 4288.005.1-T_at 0.539862 0.53986198 6.151651   1E−08 4288.005. NM_002417.2 BM455229.1 EST 1
1636 10957.018.1-F_at −0.53982 0.53982225 6.151012   1E−08 10957.018 NM_006813.1 AI547283.1 EST 1
1637 2568.006.2-B_at −0.53981 0.53980996 6.150815   1E−08 2568.006. NM_014211.1 CD385249.1 EST 1
1638 10051.015.2-F_at 0.539796 0.53979645 6.150597   1E−08 10051.015 NM_001002799. BM010546.1 EST 1
1639 2.007.1-F_at −0.53972 0.53972151 6.149392   1E−08 2.007.1 NM_000014.4 BG547500.1 EST 1
1640 5803.003.1-T_at −0.53965 0.53964973 6.148239   1E−08 5803.003. NM_002851.1 CD672822.1 EST 1
In order to find subsets of smaller amounts of polynucleotide probe sets to be used for classifying the benign or malignant status of tissues, prediction rules were constructed using the top 50, top 100, top 150 and top 200 polynucleotide probe sets of Table 4 (with identifiers no 1 to no 50, no 1 to no 100, no 1 to no 150 and no 1 to no 200). The estimated prediction accuracies by leave-one-out crossvalidation were as follows:
    • using the top 50 polynucleotide probe sets: 1 out of 24 patients with benign status were misclassified and 7 out of 70 patients with malignant status.
    • using the top 100 polynucleotide probe sets: 1 out of 24 patients with benign status were misclassified and 5 out of 70 patients with malignant status.
    • using the top 150 polynucleotide probe sets: 0 out of 24 patients with benign status were misclassified and 6 out of 70 patients with malignant status.
    • using the top 200 polynucleotide probe sets: 0 out of 24 patients with benign status were misclassified and 4 out of 70 patients with malignant status.
Table 5 contains the average profiles of the preferred 1,228 signature polynucleotide probe sets with p<10e-9 measured on the 24 benign and 70 malignant tissues of the training set. Thus, the preferred set of probes to be used for predicting the malignant status of a tissue of a future patient is reported here.
An additional 100 patients referred at the Institut Gustave Roussy for a clinical or radiological breast lesion in 2006-2007 for which a FNA was performed to assess the diagnosis of the breast lesion has been analyzed by exon profiling. The prediction rule using the preferred 1228 signature polynucleotide probe sets has been applied to this independent validation set.
The inventors have developed an optimal prediction rule based on the methodology reported previously. The preferred p-value threshold for defining signature genes was p<10e-9. When using leave-one-out cross-validation to estimate the prediction accuracy of the prediction rule with this particular threshold, the inventors accurately classified all the samples as shown in FIG. 4. This corresponds to a sensitivity of 100% and a specificity of 100%. Table 5 contains the average profiles of the preferred 1228 signature probe sets with p<10e-9 measured on the 20 benign and 74 malignant tissues of the training set. The probes with positive correlation are those which have increased expression in malignant tissues, those with negative correlation have increased expression in the benign tissues.
TABLE 4
Probe sets used to construct molecular predictor (n = 1228).
NO Probeset_Id Symbol RefSeq Location Transcrit Transcrit Transcrit2 Transcrit2
1 1756.022.2-C_at DMD NM_000109 Xp21.2 1756.022.2 10010.002.1 1756.22 1756.22
2 1756.029.1-D_at DMD NM_000110 Xp21.2 1756.029.1 10010.004.1 1756.29 1756.29
3 1756.026.1-C_at DMD NM_000111 Xp21.2 1756.026.1 10051.005.3 1756.26 1756.26
4 1756.022.4-T_at DMD NM_000112 Xp21.2 1756.022.4 10051.008.1 1756.22 1756.22
5 1756.011.1-B_at DMD NM_000113 Xp21.2 1756.011.1 10051.016.1 1756.11 1756.11
6 1308.008.1-C_at COL17A1 NM_000494 10q24.3 1308.008.1 10124.002.1 1308.8 1308.8
7 1756.022.3-F_at DMD NM_000114 Xp21.2 1756.022.3 10124.003.1 1756.22 3861.20
8 3861.020.1-D_at KRT14 NM_000526 17q12-q21 3861.020.1 10124.004.2 3861.20 4629.7
9 1756.011.1-F_at DMD NM_000115 Xp21.2 1756.011.1 10144.017.3 1756.11 1756.24
10 4629.007.1-F_at MYH11 NM_001040113 16p13.11 4629.007.1 10144.020.2 4629.7 3861.19
11 1756.022.4-B_at DMD NM_000116 Xp21.2 1756.022.4 10144.021.1 1756.22 3861.1
12 1756.024.1-F_at DMD NM_000117 Xp21.2 1756.024.1 10253.001.1 1756.24 4629.20
13 3861.019.1-T_at KRT14 NM_000526 17q12-q21 3861.019.1 10253.003.1 3861.19 1756.27
14 1756.026.1-T_at DMD NM_000118 Xp21.2 1756.026.1 10253.004.1 1756.26 3861.13
15 1756.022.1-B_at DMD NM_000119 Xp21.2 1756.022.1 1033.002.1 1756.22 3861.22
16 3861.001.1-T_at KRT14 NM_000526 17q12-q21 3861.001.1 10461.002.1 3861.1 3868.4
17 1308.008.1-T_at COL17A1 NM_000495 10q24.3 1308.008.1 10461.002.2 1308.8 4629.15
18 4629.020.1-C_at MYH11 NM_001040114 16p13.11 4629.020.1 1058.004.2 4629.20 6422.2
19 1756.027.1-T_at DMD NM_000120 Xp21.2 1756.027.1 10580.012.1 1756.27 1308.3
20 3861.013.1-T_at KRT14 NM_000526 17q12-q21 3861.013.1 1062.001.6 3861.13 3868.5
21 4629.020.1-F_at MYH11 NM_001040115 16p13.11 4629.020.1 1063.001.1 4629.20 1308.7
22 3861.001.1-B_at KRT14 NM_000526 17q12-q21 3861.001.1 1063.002.1 3861.1 1308.9
23 1756.022.4-F_at DMD NM_000121 Xp21.2 1756.022.4 11065.003.1 1756.22 3861.7
24 1756.026.1-F_at DMD NM_000122 Xp21.2 1756.026.1 11065.004.1 1756.26 4629.16
25 1756.022.2-T_at DMD NM_000123 Xp21.2 1756.022.2 11065.005.1 1756.22 3084.7
26 1756.022.2-F_at DMD NM_000124 Xp21.2 1756.022.2 11065.005.2 1756.22 26289.3
27 3861.022.1-B_at KRT14 NM_000526 17q12-q21 3861.022.1 11065.008.1 3861.22 1756.28
28 3868.004.1-D_at KRT16 NM_005557 17q12-q21 3868.004.1 11065.009.1 3868.4 4629.21
29 4629.015.1-C_at MYH11 NM_001040116 16p13.11 4629.015.1 11197.001.1 4629.15 5764.1
30 6422.002.1-E_at SFRP1 NM_003012 8p12-p11.1 6422.002.1 115207.002.1 6422.2 3815.2
31 3861.001.1-D_at KRT14 NM_000526 17q12-q21 3861.001.1 115908.002.1 3861.1 3852.20
32 1756.022.1-F_at DMD NM_000125 Xp21.2 1756.022.1 116369.006.4 1756.22 128553.3
33 1308.003.1-T_at COL17A1 NM_000496 10q24.3 1308.003.1 120.005.2 1308.3 4629.5
34 3868.005.1-B_at KRT16 NM_005557 17q12-q21 3868.005.1 1264.003.1 3868.5 4629.10
35 1308.007.1-F_at COL17A1 NM_000497 10q24.3 1308.007.1 1264.006.1 1308.7 6422.1
36 1308.009.1-F_at COL17A1 NM_000498 10q24.3 1308.009.1 1264.007.1 1308.9 3861.8
37 3861.007.1-E_at KRT14 NM_000526 17q12-q21 3861.007.1 128553.003.1 3861.7 1756.30
38 4629.016.1-D_at MYH11 NM_001040117 16p13.11 4629.016.1 130497.001.2 4629.16 3084.9
39 3084.007.1-F_at NRG1 NM_004495 8p12 3084.007.1 1308.001.1 3084.7 26289.2
40 3861.007.1-F_at KRT14 NM_000526 17q12-q21 3861.007.1 1308.002.1 3861.7 23336.1
41 26289.003.1- AK5 NM_012093 1p31 26289.003.1 1308.003.1 26289.3 3852.12
E_at
42 1756.028.1-T_at DMD NM_000126 Xp21.2 1756.028.1 1308.004.1 1756.28 26289.12
43 4629.021.1-E_at MYH11 NM_001040118 16p13.11 4629.021.1 1308.007.1 4629.21 23336.3
44 4629.020.1-D_at MYH11 NM_001040119 16p13.11 4629.020.1 1308.008.1 4629.20 26289.7
45 5764.001.1-F_at PTN NM_002825 7q33-q34 5764.001.1 1308.009.1 5764.1 84417.1
46 3815.002.3-F_at KIT NM_000222 4q11-q12 3815.002.3 1398.001.1 3815.2 3861.18
47 3852.020.1-T_at KRT5 NM_000424 12q12-q13 3852.020.1 140446.004.1 3852.20 3852.4
48 4629.007.1-E_at MYH11 NM_001040120 16p13.11 4629.007.1 140807.003.1 4629.7 90865.6
49 128553.003.1-F TSHZ2 NM_173485 20q13.2 128553.003.1 140885.010.1 128553.3 1264.3
50 26289.003.1- AK5 NM_012094 1p31 26289.003.1 140885.010.2 26289.3 26289.10
F_at
51 3815.002.2-F_at KIT NM_000223 4q11-q12 3815.002.2 140885.010.3 3815.2 1908.2
52 1756.029.1-B_at DMD NM_000127 Xp21.2 1756.029.1 140885.011.1 1756.29 3852.8
53 4629.005.1-E_at MYH11 NM_001040121 16p13.11 4629.005.1 140885.013.1 4629.5 4915.11
54 4629.010.1-B_at MYH11 NM_001040122 16p13.11 4629.010.1 140885.014.1 4629.10 5288.1
55 6422.001.1-T_at SFRP1 NM_003012 8p12-p11.1 6422.001.1 1410.001.1 6422.1 3852.6
56 5764.001.1-E_at PTN NM_002825 7q33-q34 5764.001.1 1410.002.2 5764.1 9413.3
57 3861.008.1-F_at KRT14 NM_000526 17q12-q21 3861.008.1 1410.003.2 3861.8 3815.1
58 1756.030.2-T_at DMD NM_000128 Xp21.2 1756.030.2 1410.004.2 1756.30 79937.1
59 3084.009.1-B_at NRG1 NM_004496 8p12 3084.009.1 1410.005.1 3084.9 4915.12
60 26289.002.1- AK5 NM_012095 1p31 26289.002.1 1410.006.1 26289.2 26289.5
T_at
61 1756.022.5-B_at DMD NM_000129 Xp21.2 1756.022.5 1410.007.1 1756.22 4311.9
62 4629.007.1-D_at MYH11 NM_001040123 16p13.11 4629.007.1 1410.007.2 4629.7 26289.6
63 23336.001.1- DMN NM_015286 15q26.3 23336.001.1 1410.008.1 23336.1 5288.3
C_at
64 1308.003.1-D_at COL17A1 NM_000499 10q24.3 1308.003.1 1410.009.1 1308.3 26289.4
65 1756.022.3-T_at DMD NM_000130 Xp21.2 1756.022.3 1410.010.1 1756.22 79192.2
66 3861.020.1-T_at KRT14 NM_000526 17q12-q21 3861.020.1 1410.011.1 3861.20 4638.6
67 3861.022.1-C_at KRT14 NM_000526 17q12-q21 3861.022.1 147495.005.1 3861.22 3084.8
68 3852.012.2-B_at KRT5 NM_000424 12q12-q13 3852.012.2 147495.006.1 3852.12 4311.1
69 26289.012.1- AK5 NM_012096 1p31 26289.012.1 147495.008.1 26289.12 3852.22
E_at
70 23336.003.1- DMN NM_015287 15q26.3 23336.003.1 147495.009.1 23336.3 23194.3
T_at
71 26289.007.1- AK5 NM_012097 1p31 26289.007.1 147804.004.1 26289.7 65983.9
B_at
72 84417.001.1- C2orf40 NM_032411 2q12.2 84417.001.1 152015.004.1 84417.1 1410.7
T_at
73 3861.018.1-D_at KRT14 NM_000526 17q12-q21 3861.018.1 152015.005.2 3861.18 7373.3
74 3852.004.1-B_at KRT5 NM_000424 12q12-q13 3852.004.1 162605.001.4 3852.4 10010.2
75 90865.006.1- IL33 NM_033439 9p24.1 90865.006.1 1717.007.1 90865.6 59.26
B_at
76 4629.021.1-F_at MYH11 NM_001040124 16p13.11 4629.021.1 1717.009.2 4629.21 3872.7
77 3861.018.1-T_at KRT14 NM_000526 17q12-q21 3861.018.1 1756.002.2 3861.18 84668.2
78 1756.022.1-T_at DMD NM_000131 Xp21.2 1756.022.1 1756.003.1 1756.22 1756.2
79 1264.003.1-B_at CNN1 NM_001299 19p13.2-p13.1 1264.003.1 1756.009.1 1264.3 57447.33
80 26289.010.1- AK5 NM_012098 1p31 26289.010.1 1756.011.1 26289.10 26289.9
E_at
81 3861.001.1-F_at KRT14 NM_000526 17q12-q21 3861.001.1 1756.013.1 3861.1 3872.6
82 1908.002.1-T_at EDN3 NM_001729 20q13.2-q13.3 1908.002.1 1756.022.1 1908.2 667.21
83 4629.007.1-C_at MYH11 NM_001040125 16p13.11 4629.007.1 1756.022.2 4629.7 57447.27
84 1756.022.5-T_at DMD NM_000132 Xp21.2 1756.022.5 1756.022.3 1756.22 56477.1
85 3815.002.4-B_at KIT NM_000224 4q11-q12 3815.002.4 1756.022.4 3815.2 26289.8
86 1756.022.2-B_at DMD NM_000133 Xp21.2 1756.022.2 1756.022.5 1756.22 59.24
87 1756.027.1-B_at DMD NM_000134 Xp21.2 1756.027.1 1756.024.1 1756.27 3084.4
88 3852.008.2-T_at KRT5 NM_000424 12q12-q13 3852.008.2 1756.026.1 3852.8 27122.14
89 6422.001.1-E_at SFRP1 NM_003012 8p12-p11.1 6422.001.1 1756.027.1 6422.1 286887.3
90 3861.022.1-F_at KRT14 NM_000526 17q12-q21 3861.022.1 1756.028.1 3861.22 3872.9
91 4915.011.1-D_at NTRK2 NM_001007097 9q22.1 4915.011.1 1756.029.1 4915.11 59.14
92 5288.001.1-F_at PIK3C2G NM_004570 12p12 5288.001.1 1756.030.2 5288.1 403340.1
93 3861.007.1-T_at KRT14 NM_000526 17q12-q21 3861.007.1 1908.001.1 3861.7 3852.14
94 3852.006.1-C_at KRT5 NM_000424 12q12-q13 3852.006.1 1908.002.1 3852.6 27122.1
95 9413.003.1-T_at C9orf61 NM_004816 9q13-q21 9413.003.1 1959.002.1 9413.3 8626.5
96 3861.020.1-C_at KRT14 NM_000526 17q12-q21 3861.020.1 1959.003.1 3861.20 84668.4
97 1308.008.1-D_at COL17A1 NM_000500 10q24.3 1308.008.1 2.002.1 1308.8 57447.31
98 23336.001.1- DMN NM_015288 15q26.3 23336.001.1 2.005.1 23336.1 3084.12
T_at
99 3815.001.1-F_at KIT NM_000225 4q11-q12 3815.001.1 2.013.1 3815.1 3852.5
100 1756.022.5-F_at DMD NM_000135 Xp21.2 1756.022.5 2.018.1 1756.22 3866.3
101 79937.001.1- CNTNAP3 NM_033655 9p13.1 79937.001.1 2.022.1 79937.1 3866.8
T_at
102 4915.012.1-E_at NTRK2 NM_001007098 9q22.1 4915.012.1 2.024.1 4915.12 3852.9
103 3861.022.1-T_at KRT14 NM_000526 17q12-q21 3861.022.1 2.025.1 3861.22 59.15
104 26289.005.1- AK5 NM_012099 1p31 26289.005.1 2115.001.2 26289.5 79937.2
T_at
105 3815.002.3-B_at KIT NM_000226 4q11-q12 3815.002.3 2115.003.1 3815.2 7153.2
106 4311.009.1-F_at MME NM_000902 3q25.1-q25.2 4311.009.1 2115.006.1 4311.9 4281.10
107 26289.006.1- AK5 NM_012100 1p31 26289.006.1 2115.007.1 26289.6 59.8
T_at
108 5288.003.1-F_at PIK3C2G NM_004570 12p12 5288.003.1 2115.008.1 5288.3 1264.7
109 4629.020.1-B_at MYH11 NM_001040126 16p13.11 4629.020.1 2115.011.1 4629.20 3084.2
110 26289.007.1- AK5 NM_012101 1p31 26289.007.1 2115.012.1 26289.7 5137.4
D_at
111 3815.002.1-B_at KIT NM_000227 4q11-q12 3815.002.1 2115.014.1 3815.2 4629.22
112 26289.004.1- AK5 NM_012102 1p31 26289.004.1 2115.015.1 26289.4 3852.13
T_at
113 79192.002.2- IRX1 NM_024337 5p15.3 79192.002.2 2119.005.1 79192.2 59.12
T_at
114 4638.006.1-D_at MYLK NM_005965 3q21 4638.006.1 2119.006.1 4638.6 23336.2
115 3084.008.1-F_at NRG1 NM_004497 8p12 3084.008.1 221120.006.1 3084.8 3866.11
116 4311.001.2-T_at MME NM_000903 3q25.1-q25.2 4311.001.2 2232.014.1 4311.1 59.31
117 3815.002.1-D_at KIT NM_000228 4q11-q12 3815.002.1 22974.007.1 3815.2 57447.30
118 4629.020.1-T_at MYH11 NM_001040127 16p13.11 4629.020.1 22974.008.1 4629.20 1410.3
119 1756.026.1-B_at DMD NM_000136 Xp21.2 1756.026.1 23092.004.1 1756.26 3866.9
120 3852.022.1-T_at KRT5 NM_000424 12q12-q13 3852.022.1 23194.003.1 3852.22 440421.1
121 4629.015.1-D_at MYH11 NM_001040128 16p13.11 4629.015.1 23266.001.3 4629.15 57447.41
122 26289.007.1- AK5 NM_012103 1p31 26289.007.1 23266.008.1 26289.7 3872.10
C_at
123 23194.003.1- FBXL7 NM_012304 5p15.1 23194.003.1 23266.008.2 23194.3 4629.6
C_at
124 3815.002.1-F_at KIT NM_000229 4q11-q12 3815.002.1 2327.002.1 3815.2 3866.12
125 26289.007.1- AK5 NM_012104 1p31 26289.007.1 2327.002.2 26289.7 57447.21
T_at
126 65983.009.1- GRAMD3 NM_023927 5q23.2 65983.009.1 2327.003.4 65983.9 8626.7
B_at
127 23336.001.1- DMN NM_015289 15q26.3 23336.001.1 23284.007.1 23336.1 72.1
F_at
128 1410.007.2-B_at CRYAB NM_001885 11q22.3-q23.1 1410.007.2 23321.014.1 1410.7 3866.6
129 1756.029.1-F_at DMD NM_000137 Xp21.2 1756.029.1 23336.001.1 1756.29 65983.8
130 7373.003.6-C_at COL14A1 NM_021110 8q23 7373.003.6 23336.002.1 7373.3 65983.13
131 10010.002.1- TANK NM_004180 2q24-q31 10010.002.1 23336.003.1 10010.2 27122.7
E_at
132 59.026.1-B_at ACTA2 NM_001613 10q23.3 59.026.1 2335.002.1 59.26 59.9
133 4915.011.1-F_at NTRK2 NM_001007099 9q22.1 4915.011.1 2335.005.1 4915.11 59.23
134 3872.007.1-D_at KRT17 NM_000422 17q12-q21 3872.007.1 2335.006.1 3872.7 1908.1
135 26289.002.1- AK5 NM_012105 1p31 26289.002.1 2335.006.2 26289.2 4915.8
D_at
136 84668.002.1- FAM126A NM_032581 7p15.3 84668.002.1 2335.009.1 84668.2 57447.35
C_at
137 1756.002.2-T_at DMD NM_000138 Xp21.2 1756.002.2 2335.013.1 1756.2 667.22
138 57447.033.1- NDRG2 NM_016250 14q11.2 57447.033.1 2335.016.1 57447.33 2115.1
C_at
139 26289.009.1- AK5 NM_012106 1p31 26289.009.1 2335.017.1 26289.9 27303.4
E_at
140 3872.006.1-F_at KRT17 NM_000422 17q12-q21 3872.006.1 2335.024.2 3872.6 59.3
141 3861.022.1-D_at KRT14 NM_000526 17q12-q21 3861.022.1 2335.025.1 3861.22 65983.4
142 3861.020.1-B_at KRT14 NM_000526 17q12-q21 3861.020.1 2335.025.3 3861.20 26289.13
143 667.021.1-B_at DST NM_001723 6p12.1 667.021.1 2335.027.1 667.21 3866.4
144 57447.027.1- NDRG2 NM_016251 14q11.2 57447.027.1 2335.028.1 57447.27 57447.37
F_at
145 56477.001.1- CCL28 NM_148672 5p12 56477.001.1 2335.032.1 56477.1 59.22
D_at
146 26289.008.1- AK5 NM_012107 1p31 26289.008.1 2335.035.1 26289.8 147495.8
F_at
147 59.024.2-D_at ACTA2 NM_001613 10q23.3 59.024.2 2335.045.1 59.24 2.18
148 4629.005.1-T_at MYH11 NM_001040129 16p13.11 4629.005.1 2335.053.1 4629.5 140807.3
149 3815.002.1-T_at KIT NM_000230 4q11-q12 3815.002.1 23650.003.1 3815.2 2115.8
150 23336.001.1- DMN NM_015290 15q26.3 23336.001.1 23650.005.1 23336.1 57447.34
B_at
151 3084.004.2-F_at NRG1 NM_004498 8p12 3084.004.2 23650.011.1 3084.4 3866.1
152 27122.014.2- DKK3 NM_001018057 11p15.2 27122.014.2 23650.011.2 27122.14 1959.3
T_at
153 26289.008.1- AK5 NM_012108 1p31 26289.008.1 23650.019.1 26289.8 389432.2
C_at
154 286887.003.2-B KRT6C NM_173086 12q13.13 286887.003.2 23650.020.1 286887.3 389734.1
155 4629.005.1-F_at MYH11 NM_001040130 16p13.11 4629.005.1 24137.004.1 4629.5 3855.1
156 3872.009.1-T_at KRT17 NM_000422 17q12-q21 3872.009.1 244.003.1 3872.9 3084.6
157 59.014.2-D_at ACTA2 NM_001613 10q23.3 59.014.2 244.011.1 59.14 2115.11
158 403340.001.2-B MGC70870 NM_203481 — 403340.001.2 244.012.1 403340.1 65983.5
159 3852.014.1-F_at KRT5 NM_000424 12q12-q13 3852.014.1 2487.001.1 3852.14 2119.6
160 27122.001.1- DKK3 NM_001018058 11p15.2 27122.001.1 2568.001.1 27122.1 3866.7
T_at
161 3815.002.3-T_at KIT NM_000231 4q11-q12 3815.002.3 2568.001.2 3815.2 3866.13
162 3852.008.1-E_at KRT5 NM_000424 12q12-q13 3852.008.1 2568.002.1 3852.8 27122.13
163 26289.012.1- AK5 NM_012109 1p31 26289.012.1 2568.002.2 26289.12 27122.6
T_at
164 26289.007.1- AK5 NM_012110 1p31 26289.007.1 2568.003.1 26289.7 4240.4
F_at
165 4638.006.1-T_at MYLK NM_005966 3q21 4638.006.1 2568.003.2 4638.6 3866.10
166 8626.005.1-B_at TP63 NM_003722 3q28 8626.005.1 2568.005.1 8626.5 7018.29
167 3815.002.4-T_at KIT NM_000232 4q11-q12 3815.002.4 2568.005.2 3815.2 1410.2
168 84668.004.1- FAM126A NM_032581 7p15.3 84668.004.1 2568.006.1 84668.4 59.34
F_at
169 3872.007.1-F_at KRT17 NM_000422 17q12-q21 3872.007.1 25802.003.1 3872.7 27122.19
170 57447.031.1- NDRG2 NM_016252 14q11.2 57447.031.1 25802.004.1 57447.31 5156.1
E_at
171 3084.012.3-T_at NRG1 NM_004499 8p12 3084.012.3 25802.008.1 3084.12 57447.10
172 3852.005.1-T_at KRT5 NM_000424 12q12-q13 3852.005.1 2582.007.2 3852.5 358.18
173 84417.001.2- C2orf40 NM_032411 2q12.2 84417.001.2 25925.001.1 84417.1 7373.1
T_at
174 3866.003.2-T_at KRT15 NM_002275 17q21.2 3866.003.2 25925.006.1 3866.3 57447.29
175 3866.008.1-C_at KRT15 NM_002275 17q21.2 3866.008.1 25925.007.1 3866.8 79068.10
176 3852.009.1-F_at KRT5 NM_000424 12q12-q13 3852.009.1 25925.008.1 3852.9 59.4
177 59.015.1-B_at ACTA2 NM_001613 10q23.3 59.015.1 25925.009.1 59.15 2115.12
178 79937.002.1- CNTNAP3 NM_033655 9p13.1 79937.002.1 25925.011.1 79937.2 2115.7
F_at
179 7153.002.6-F_at TOP2A NM_001067 17q21-q22 7153.002.6 259266.003.1 7153.2 59.40
180 4281.010.1-B_at MID1 NM_000381 Xp22 4281.010.1 26289.002.1 4281.10 130497.1
181 59.008.1-B_at ACTA2 NM_001613 10q23.3 59.008.1 26289.003.1 59.8 140885.14
182 1264.007.1-T_at CNN1 NM_001299 19p13.2-p13.1 1264.007.1 26289.004.1 1264.7 3866.5
183 3868.004.1-T_at KRT16 NM_005557 17q12-q21 3868.004.1 26289.005.1 3868.4 8404.28
184 3084.002.1-F_at NRG1 NM_004500 8p12 3084.002.1 26289.006.1 3084.2 3860.7
185 5137.004.2-T_at PDE1C NM_005020 7p15.1-p14.3 5137.004.2 26289.007.1 5137.4 4638.3
186 4629.022.1-T_at MYH11 NM_001040131 16p13.11 4629.022.1 26289.008.1 4629.22 25925.8
187 4915.011.1-T_at NTRK2 NM_001007100 9q22.1 4915.011.1 26289.009.1 4915.11 23650.11
188 3852.013.1-E_at KRT5 NM_000424 12q12-q13 3852.013.1 26289.010.1 3852.13 3852.17
189 59.012.2-T_at ACTA2 NM_001613 10q23.3 59.012.2 26289.012.1 59.12 4915.5
190 59.015.1-F_at ACTA2 NM_001613 10q23.3 59.015.1 26289.013.1 59.15 1756.3
191 4638.006.2-T_at MYLK NM_005967 3q21 4638.006.2 2707.002.1 4638.6 4638.14
192 23336.002.1- DMN NM_015291 15q26.3 23336.002.1 27122.001.1 23336.2 2707.2
B_at
193 3868.005.1-C_at KRT16 NM_005557 17q12-q21 3868.005.1 27122.002.1 3868.5 4638.11
194 3866.011.2-D_at KRT15 NM_002275 17q21.2 3866.011.2 27122.006.1 3866.11 7373.2
195 56477.001.1- CCL28 NM_148672 5p12 56477.001.1 27122.006.2 56477.1 5608.2
T_at
196 3815.001.1-T_at KIT NM_000233 4q11-q12 3815.001.1 27122.007.1 3815.1 1756.13
197 4311.001.1-T_at MME NM_000904 3q25.1-q25.2 4311.001.1 27122.013.1 4311.1 2115.6
198 1264.003.1-D_at CNN1 NM_001299 19p13.2-p13.1 1264.003.1 27122.014.1 1264.3 6376.1
199 59.031.1-T_at ACTA2 NM_001613 10q23.3 59.031.1 27122.014.2 59.31 8404.2
200 57447.030.1- NDRG2 NM_016253 14q11.2 57447.030.1 27122.016.1 57447.30 1264.6
B_at
201 1410.003.2-B_at CRYAB NM_001885 11q22.3-q23.1 1410.003.2 27122.017.1 1410.3 25925.1
202 3866.009.2-D_at KRT15 NM_002275 17q21.2 3866.009.2 27122.018.1 3866.9 8404.35
203 59.026.1-T_at ACTA2 NM_001613 10q23.3 59.026.1 27122.019.1 59.26 2.22
204 440421.001.1-T 440421.001.1 27303.004.1 440421.1 27122.16
205 1756.022.4-D_at DMD NM_000139 Xp21.2 1756.022.4 2824.001.2 1756.22 57447.25
206 65983.009.1- GRAMD3 NM_023927 5q23.2 65983.009.1 285203.001.2 65983.9 1717.7
D_at
207 57447.041.1- NDRG2 NM_016254 14q11.2 57447.041.1 286887.003.2 57447.41 9768.4
T_at
208 3872.010.2-D_at KRT17 NM_000422 17q12-q21 3872.010.2 2893.002.2 3872.10 1410.4
209 4629.006.2-T_at MYH11 NM_001040132 16p13.11 4629.006.2 2893.006.2 4629.6 2327.2
210 3861.018.1-F_at KRT14 NM_000526 17q12-q21 3861.018.1 29089.001.1 3861.18 1308.4
211 3815.002.2-T_at KIT NM_000234 4q11-q12 3815.002.2 29089.003.1 3815.2 2568.5
212 3866.012.2-D_at KRT15 NM_002275 17q21.2 3866.012.2 29127.002.1 3866.12 2568.1
213 57447.021.1- NDRG2 NM_016255 14q11.2 57447.021.1 29127.007.1 57447.21 2893.6
D_at
214 59.015.1-T_at ACTA2 NM_001613 10q23.3 59.015.1 29127.013.1 59.15 3872.16
215 8626.007.1-F_at TP63 NM_003722 3q28 8626.007.1 29127.019.1 8626.7 9413.6
216 5288.001.1-B_at PIK3C2G NM_004570 12p12 5288.001.1 29127.019.2 5288.1 72.5
217 72.001.1-B_at ACTG2 NM_001615 2p13.1 72.001.1 29127.022.1 72.1 27122.18
218 3866.006.2-D_at KRT15 NM_002275 17q21.2 3866.006.2 2938.001.1 3866.6 7153.5
219 3852.004.1-T_at KRT5 NM_000424 12q12-q13 3852.004.1 2982.002.1 3852.4 7018.26
220 4629.016.1-F_at MYH11 NM_001040133 16p13.11 4629.016.1 2982.012.1 4629.16 7402.14
221 4629.007.1-T_at MYH11 NM_001040134 16p13.11 4629.007.1 2982.013.2 4629.7 140446.4
222 65983.008.1- GRAMD3 NM_023927 5q23.2 65983.008.1 2982.014.1 65983.8 59.38
T_at
223 65983.013.1- GRAMD3 NM_023927 5q23.2 65983.013.1 2982.015.1 65983.13 4240.9
F_at
224 3084.004.1-F_at NRG1 NM_004501 8p12 3084.004.1 2995.001.1 3084.4 57447.8
225 27122.007.1- DKK3 NM_001018059 11p15.2 27122.007.1 29997.008.1 27122.7 2582.7
F_at
226 3866.008.1-D_at KRT15 NM_002275 17q21.2 3866.008.1 29997.012.1 3866.8 4638.9
227 26289.009.1- AK5 NM_012111 1p31 26289.009.1 29997.016.1 26289.9 3861.23
T_at
228 59.009.1-B_at ACTA2 NM_001613 10q23.3 59.009.1 301.004.1 59.9 5858.3
229 4629.010.1-D_at MYH11 NM_001040135 16p13.11 4629.010.1 301.005.1 4629.10 147495.5
230 59.023.1-B_at ACTA2 NM_001613 10q23.3 59.023.1 301.008.1 59.23 4915.4
231 26289.002.1- AK5 NM_012112 1p31 26289.002.1 301.013.1 26289.2 8626.2
F_at
232 1908.001.1-T_at EDN3 NM_001730 20q13.2-q13.3 1908.001.1 301.015.1 1908.1 59.42
233 4915.008.1-F_at NTRK2 NM_001007101 9q22.1 4915.008.1 3084.002.1 4915.8 4833.4
234 23336.002.1- DMN NM_015292 15q26.3 23336.002.1 3084.004.1 23336.2 2568.6
T_at
235 3861.008.1-C_at KRT14 NM_000526 17q12-q21 3861.008.1 3084.004.2 3861.8 57447.4
236 3861.008.1-D_at KRT14 NM_000526 17q12-q21 3861.008.1 3084.005.1 3861.8 27122.17
237 57447.035.1- NDRG2 NM_016256 14q11.2 57447.035.1 3084.006.1 57447.35 59.33
E_at
238 3861.018.1-C_at KRT14 NM_000526 17q12-q21 3861.018.1 3084.007.1 3861.18 27122.2
239 1308.003.1-B_at COL17A1 NM_000501 10q24.3 1308.003.1 3084.008.1 1308.3 3880.11
240 667.022.1-B_at DST NM_001724 6p12.1 667.022.1 3084.009.1 667.22 3872.14
241 3866.011.2-T_at KRT15 NM_002275 17q21.2 3866.011.2 3084.010.1 3866.11 162605.1
242 2115.001.2-F_at ETV1 NM_004956 7p21.3 2115.001.2 3084.011.1 2115.1 5858.1
243 3866.011.2-B_at KRT15 NM_002275 17q21.2 3866.011.2 3084.012.1 3866.11 65983.10
244 26289.010.1- AK5 NM_012113 1p31 26289.010.1 3084.012.2 26289.10 8404.5
T_at
245 27303.004.1- RBMS3 NM_001003792 3p24-p23 27303.004.1 3084.012.3 27303.4 2487.1
E_at
246 59.003.1-B_at ACTA2 NM_001613 10q23.3 59.003.1 3178.003.1 59.3 147495.9
247 4311.009.1-C_at MME NM_000905 3q25.1-q25.2 4311.009.1 3204.001.1 4311.9 65983.3
248 7373.003.6-B_at COL14A1 NM_021110 8q23 7373.003.6 338707.006.1 7373.3 1717.9
249 65983.004.1- GRAMD3 NM_023927 5q23.2 65983.004.1 339965.001.2 65983.4 140885.11
T_at
250 26289.013.1- AK5 NM_012114 1p31 26289.013.1 3426.001.1 26289.13 3832.2
D_at
251 3866.004.1-F_at KRT15 NM_002275 17q21.2 3866.004.1 3426.002.1 3866.4 3880.5
252 56477.001.1- CCL28 NM_148672 5p12 56477.001.1 3426.002.2 56477.1 6595.12
F_at
253 57447.037.1- NDRG2 NM_016257 14q11.2 57447.037.1 3459.005.1 57447.37 9768.5
F_at
254 59.022.2-T_at ACTA2 NM_001613 10q23.3 59.022.2 3479.003.1 59.22 285203.1
255 147495.008.1-F APCDD1 NM_153000 18p11.22 147495.008.1 358.012.1 147495.8 147495.6
256 2.018.1-T_at A2M NM_000014 12p13.3-p12.3 2.018.1 358.018.1 2.18 1959.2
257 140807.003.1-E KRT72 NM_080747 12q13.13 140807.003.1 3815.001.1 140807.3 7018.14
258 65983.009.1- GRAMD3 NM_023927 5q23.2 65983.009.1 3815.002.1 65983.9 5858.4
T_at
259 84668.002.1- FAM126A NM_032581 7p15.3 84668.002.1 3815.002.2 84668.2 8404.8
F_at
260 3872.007.1-C_at KRT17 NM_000422 17q12-q21 3872.007.1 3815.002.3 3872.7 4240.11
261 2115.008.1-T_at ETV1 NM_004956 7p21.3 2115.008.1 3815.002.4 2115.8 94274.2
262 65983.004.2- GRAMD3 NM_023927 5q23.2 65983.004.2 3832.002.1 65983.4 4638.15
T_at
263 57447.034.1- NDRG2 NM_016258 14q11.2 57447.034.1 3852.004.1 57447.34 57447.43
D_at
264 3866.001.1-F_at KRT15 NM_002275 17q21.2 3866.001.1 3852.005.1 3866.1 59.39
265 3866.008.1-T_at KRT15 NM_002275 17q21.2 3866.008.1 3852.006.1 3866.8 25802.3
266 1959.003.1-C_at EGR2 NM_000399 10q21.1 1959.003.1 3852.008.1 1959.3 57447.17
267 389432.002.1-T SAMD5 NM_001030060 6q24.3 389432.002.1 3852.008.2 389432.2 7018.28
268 389734.001.1-T 389734.001.1 3852.009.1 389734.1 57447.12
269 3855.001.2-D_at KRT7 NM_005556 12q12-q13 3855.001.2 3852.012.2 3855.1 57447.6
270 3866.003.1-T_at KRT15 NM_002275 17q21.2 3866.003.1 3852.013.1 3866.3 9493.6
271 3084.006.1-F_at NRG1 NM_004502 8p12 3084.006.1 3852.014.1 3084.6 9493.4
272 4915.008.1-B_at NTRK2 NM_001007102 9q22.1 4915.008.1 3852.017.1 4915.8 7169.15
273 2115.011.1-T_at ETV1 NM_004956 7p21.3 2115.011.1 3852.020.1 2115.11 57451.1
274 65983.005.1- GRAMD3 NM_023927 5q23.2 65983.005.1 3852.021.1 65983.5 8404.4
T_at
275 84668.004.1- FAM126A NM_032581 7p15.3 84668.004.1 3852.022.1 84668.4 3855.4
T_at
276 59.015.2-T_at ACTA2 NM_001613 10q23.3 59.015.2 3852.023.1 59.15 9452.1
277 2119.006.1-B_at ETV5 NM_004454 3q28 2119.006.1 3855.001.2 2119.6 57447.40
278 4638.006.2-F_at MYLK NM_005968 3q21 4638.006.2 3855.004.2 4638.6 3426.1
279 3866.007.2-D_at KRT15 NM_002275 17q21.2 3866.007.2 3860.007.1 3866.7 10253.1
280 59.014.1-T_at ACTA2 NM_001613 10q23.3 59.014.1 3860.008.1 59.14 9073.1
281 3866.001.2-F_at KRT15 NM_002275 17q21.2 3866.001.2 3861.001.1 3866.1 51201.5
282 1308.008.1-B_at COL17A1 NM_000502 10q24.3 1308.008.1 3861.007.1 1308.8 9477.6
283 59.026.1-F_at ACTA2 NM_001613 10q23.3 59.026.1 3861.008.1 59.26 57447.28
284 3866.013.1-T_at KRT15 NM_002275 17q21.2 3866.013.1 3861.013.1 3866.13 25925.7
285 1264.007.1-F_at CNN1 NM_001299 19p13.2-p13.1 1264.007.1 3861.018.1 1264.7 4281.8
286 3866.007.2-T_at KRT15 NM_002275 17q21.2 3866.007.2 3861.019.1 3866.7 90231.1
287 27122.013.1- DKK3 NM_001018060 11p15.2 27122.013.1 3861.020.1 27122.13 358.12
T_at
288 27122.006.2- DKK3 NM_001018061 11p15.2 27122.006.2 3861.022.1 27122.6 3852.21
T_at
289 3866.006.2-T_at KRT15 NM_002275 17q21.2 3866.006.2 3861.023.1 3866.6 57447.48
290 3866.009.2-T_at KRT15 NM_002275 17q21.2 3866.009.2 3866.001.1 3866.9 7018.25
291 4240.004.1-D_at MFGE8 NM_005928 15q25 4240.004.1 3866.001.2 4240.4 5608.4
292 3866.010.1-C_at KRT15 NM_002275 17q21.2 3866.010.1 3866.002.1 3866.10 4306.2
293 3866.009.2-B_at KRT15 NM_002275 17q21.2 3866.009.2 3866.003.1 3866.9 4288.4
294 3866.009.1-T_at KRT15 NM_002275 17q21.2 3866.009.1 3866.003.2 3866.9 57447.2
295 4629.006.1-T_at MYH11 NM_001040136 16p13.11 4629.006.1 3866.004.1 4629.6 4281.18
296 7018.029.1-B_at TF NM_001063 3q22.1 7018.029.1 3866.005.1 7018.29 10144.20
297 1410.002.2-B_at CRYAB NM_001885 11q22.3-q23.1 1410.002.2 3866.006.1 1410.2 6876.16
298 3866.012.1-T_at KRT15 NM_002275 17q21.2 3866.012.1 3866.006.2 3866.12 51203.4
299 59.034.2-D_at ACTA2 NM_001613 10q23.3 59.034.2 3866.007.1 59.34 2335.28
300 27122.019.1- DKK3 NM_001018062 11p15.2 27122.019.1 3866.007.2 27122.19 81557.6
F_at
301 5156.001.1-T_at PDGFRA NM_006206 4q11-q13 5156.001.1 3866.008.1 5156.1 3866.2
302 389734.001.2-T 389734.001.2 3866.009.1 389734.1 55107.6
303 27122.014.1- DKK3 NM_001018063 11p15.2 27122.014.1 3866.009.2 27122.14 57447.9
T_at
304 57447.010.3- NDRG2 NM_016259 14q11.2 57447.010.3 3866.010.1 57447.10 2115.15
T_at
305 358.018.1-F_at AQP1 NM_198098 7p14 358.018.1 3866.011.1 358.18 8404.1
306 3866.006.1-T_at KRT15 NM_002275 17q21.2 3866.006.1 3866.011.2 3866.6 57447.24
307 7373.001.1-T_at COL14A1 NM_021110 8q23 7373.001.1 3866.012.1 7373.1 79608.2
308 26289.012.1- AK5 NM_012115 1p31 26289.012.1 3866.012.2 26289.12 8404.23
B_at
309 57447.029.1- NDRG2 NM_016260 14q11.2 57447.029.1 3866.013.1 57447.29 3426.2
T_at
310 358.018.1-B_at AQP1 NM_198098 7p14 358.018.1 3868.004.1 358.18 2335.27
311 79068.010.1- FTO NM_001080432 16q12.2 79068.010.1 3868.005.1 79068.10 11065.9
B_at
312 59.024.1-B_at ACTA2 NM_001613 10q23.3 59.024.1 3872.005.1 59.24 140885.13
313 59.004.1-B_at ACTA2 NM_001613 10q23.3 59.004.1 3872.006.1 59.4 25802.4
314 3866.011.1-T_at KRT15 NM_002275 17q21.2 3866.011.1 3872.007.1 3866.11 5156.5
315 3866.013.1-E_at KRT15 NM_002275 17q21.2 3866.013.1 3872.009.1 3866.13 25802.8
316 3866.010.1-D_at KRT15 NM_002275 17q21.2 3866.010.1 3872.010.2 3866.10 7169.22
317 59.004.1-T_at ACTA2 NM_001613 10q23.3 59.004.1 3872.014.1 59.4 23266.1
318 2115.012.1-T_at ETV1 NM_004956 7p21.3 2115.012.1 3872.016.1 2115.12 29127.19
319 2.018.1-D_at A2M NM_000014 12p13.3-p12.3 2.018.1 3872.018.1 2.18 10253.4
320 2115.007.1-T_at ETV1 NM_004956 7p21.3 2115.007.1 3880.005.1 2115.7 10124.2
321 59.040.1-T_at ACTA2 NM_001613 10q23.3 59.040.1 3880.011.1 59.40 8404.32
322 130497.001.2-T OSR1 NM_145260 2p24.1 130497.001.2 389432.002.1 130497.1 84441.2
323 140885.014.1-T SIRPA NM_001040022 20p13 140885.014.1 389734.001.1 140885.14 2.13
324 3866.005.1-F_at KRT15 NM_002275 17q21.2 3866.005.1 389734.001.2 3866.5 2.24
325 7373.003.3-F_at COL14A1 NM_021110 8q23 7373.003.3 399687.001.1 7373.3 1756.9
326 8404.028.1-F_at SPARCL1 NM_004684 4q22.1 8404.028.1 403340.001.2 8404.28 7091.14
327 3860.007.1-D_at KRT13 NM_002274 17q12-q21.2 3860.007.1 4094.001.1 3860.7 115207.2
328 4638.003.1-C_at MYLK NM_005969 3q21 4638.003.1 4094.002.1 4638.3 4281.1
329 3872.009.1-E_at KRT17 NM_000422 17q12-q21 3872.009.1 4147.004.1 3872.9 57447.44
330 59.004.2-T_at ACTA2 NM_001613 10q23.3 59.004.2 4147.005.2 59.4 8626.6
331 3872.006.1-C_at KRT17 NM_000422 17q12-q21 3872.006.1 4147.011.1 3872.6 57447.51
332 3866.005.1-C_at KRT15 NM_002275 17q21.2 3866.005.1 4147.012.1 3866.5 1063.1
333 25925.008.1- ZNF521 NM_015461 18q11.2 25925.008.1 4240.001.1 25925.8 1308.1
T_at
334 23650.011.2- TRIM29 NM_012101 11q22-q23 23650.011.2 4240.004.1 23650.11 2115.14
T_at
335 3866.012.2-T_at KRT15 NM_002275 17q21.2 3866.012.2 4240.009.1 3866.12 5284.4
336 3852.017.1-D_at KRT5 NM_000424 12q12-q13 3852.017.1 4240.011.1 3852.17 2982.2
337 4915.005.1-T_at NTRK2 NM_001007103 9q22.1 4915.005.1 4240.011.3 4915.5 57447.47
338 4638.003.1-B_at MYLK NM_005970 3q21 4638.003.1 4240.015.1 4638.3 5803.6
339 1756.003.1-B_at DMD NM_000140 Xp21.2 1756.003.1 4281.001.1 1756.3 57447.39
340 4638.006.1-F_at MYLK NM_005971 3q21 4638.006.1 4281.008.2 4638.6 6876.11
341 57447.035.1- NDRG2 NM_016261 14q11.2 57447.035.1 4281.009.1 57447.35 9768.2
F_at
342 4638.014.1-T_at MYLK NM_005972 3q21 4638.014.1 4281.010.1 4638.14 140885.10
343 7373.003.4-T_at COL14A1 NM_021110 8q23 7373.003.4 4281.012.1 7373.3 4638.20
344 27122.014.2- DKK3 NM_001018064 11p15.2 27122.014.2 4281.012.2 27122.14 7373.4
D_at
345 3866.007.1-T_at KRT15 NM_002275 17q21.2 3866.007.1 4281.014.1 3866.7 4281.15
346 2707.002.1-E_at GJB3 NM_001005752 1p34 2707.002.1 4281.015.1 2707.2 8404.13
347 59.024.1-T_at ACTA2 NM_001613 10q23.3 59.024.1 4281.018.1 59.24 90293.1
348 23650.011.1- TRIM29 NM_012101 11q22-q23 23650.011.1 4281.023.1 23650.11 2335.6
T_at
349 4638.011.1-F_at MYLK NM_005973 3q21 4638.011.1 4288.004.1 4638.11 57447.22
350 7373.002.1-F_at COL14A1 NM_021110 8q23 7373.002.1 4288.005.1 7373.2 8404.30
351 3866.013.1-F_at KRT15 NM_002275 17q21.2 3866.013.1 4288.006.1 3866.13 5803.2
352 5608.002.1-T_at MAP2K6 NM_002758 17q24.3 5608.002.1 4288.006.2 5608.2 84441.5
353 3866.001.1-C_at KRT15 NM_002275 17q21.2 3866.001.1 4288.007.1 3866.1 7091.15
354 1756.013.1-B_at DMD NM_000141 Xp21.2 1756.013.1 4288.008.1 1756.13 2119.5
355 2115.006.1-E_at ETV1 NM_004956 7p21.3 2115.006.1 4288.009.1 2115.6 79608.8
356 6376.001.2-F_at CX3CL1 NM_002996 16q13 6376.001.2 4306.002.1 6376.1 8404.22
357 3084.004.1-B_at NRG1 NM_004503 8p12 3084.004.1 4311.001.1 3084.4 8404.34
358 3815.002.4-F_at KIT NM_000235 4q11-q12 3815.002.4 4311.001.2 3815.2 57447.49
359 8404.002.1-D_at SPARCL1 NM_004684 4q22.1 8404.002.1 4311.009.1 8404.2 5311.2
360 1264.006.1-T_at CNN1 NM_001299 19p13.2-p13.1 1264.006.1 440421.001.1 1264.6 2335.25
361 59.022.2-D_at ACTA2 NM_001613 10q23.3 59.022.2 4601.014.1 59.22 4147.12
362 25925.001.1- ZNF521 NM_015461 18q11.2 25925.001.1 4629.005.1 25925.1 301.15
T_at
363 4638.006.2-B_at MYLK NM_005974 3q21 4638.006.2 4629.006.1 4638.6 301.4
364 7373.003.5-B_at COL14A1 NM_021110 8q23 7373.003.5 4629.006.2 7373.3 7091.1
365 8404.035.1-B_at SPARCL1 NM_004684 4q22.1 8404.035.1 4629.007.1 8404.35 8404.21
366 59.012.1-T_at ACTA2 NM_001613 10q23.3 59.012.1 4629.010.1 59.12 53335.2
367 3852.017.1-T_at KRT5 NM_000424 12q12-q13 3852.017.1 4629.015.1 3852.17 5284.3
368 3866.012.2-B_at KRT15 NM_002275 17q21.2 3866.012.2 4629.016.1 3866.12 23650.20
369 2.022.1-B_at A2M NM_000014 12p13.3-p12.3 2.022.1 4629.020.1 2.22 57447.42
370 27122.016.1- DKK3 NM_001018065 11p15.2 27122.016.1 4629.021.1 27122.16 6876.23
F_at
371 4311.009.1-B_at MME NM_000906 3q25.1-q25.2 4311.009.1 4629.022.1 4311.9 6876.2
372 59.031.2-T_at ACTA2 NM_001613 10q23.3 59.031.2 4638.003.1 59.31 65983.7
373 4311.009.1-T_at MME NM_000907 3q25.1-q25.2 4311.009.1 4638.006.1 4311.9 152015.4
374 3866.006.2-B_at KRT15 NM_002275 17q21.2 3866.006.2 4638.006.2 3866.6 6285.1
375 57447.025.2- NDRG2 NM_016262 14q11.2 57447.025.2 4638.009.1 57447.25 6289.5
T_at
376 1717.007.1-F_at DHCR7 NM_001360 11q13.2-q13.5 1717.007.1 4638.011.1 1717.7 9232.2
377 59.004.2-D_at ACTA2 NM_001613 10q23.3 59.004.2 4638.014.1 59.4 3084.11
378 3866.007.2-B_at KRT15 NM_002275 17q21.2 3866.007.2 4638.015.1 3866.7 3872.5
379 3866.010.1-F_at KRT15 NM_002275 17q21.2 3866.010.1 4638.020.1 3866.10 81704.8
380 9768.004.1-D_at KIAA0101 NM_001029989 15q22.31 9768.004.1 4744.004.1 9768.4 338707.6
381 3084.012.2-T_at NRG1 NM_004504 8p12 3084.012.2 4751.002.1 3084.12 23266.8
382 1410.004.2-B_at CRYAB NM_001885 11q22.3-q23.1 1410.004.2 4781.002.2 1410.4 120.5
383 59.008.1-D_at ACTA2 NM_001613 10q23.3 59.008.1 4781.006.2 59.8 4281.9
384 57447.030.1- NDRG2 NM_016263 14q11.2 57447.030.1 4781.007.1 57447.30 4094.1
C_at
385 2327.002.1-D_at FMO2 NM_001460 1q23-q25 2327.002.1 4781.014.2 2327.2 2995.1
386 1308.004.1-B_at COL17A1 NM_000503 10q24.3 1308.004.1 4781.015.2 1308.4 2335.17
387 2568.005.2-B_at GABRP NM_014211 5q33-q34 2568.005.2 4781.016.1 2568.5 5284.1
388 2568.001.1-T_at GABRP NM_014211 5q33-q34 2568.001.1 4833.004.1 2568.1 8404.26
389 3084.004.2-T_at NRG1 NM_004505 8p12 3084.004.2 4833.010.1 3084.4 2335.9
390 7373.003.4-B_at COL14A1 NM_021110 8q23 7373.003.4 4915.004.1 7373.3 10461.2
391 7153.002.2-D_at TOP2A NM_001067 17q21-q22 7153.002.2 4915.005.1 7153.2 7091.10
392 2893.006.2-T_at GRIA4 NM_000829 11q22 2893.006.2 4915.008.1 2893.6 79895.1
393 3872.016.1-D_at KRT17 NM_000422 17q12-q21 3872.016.1 4915.011.1 3872.16 57447.38
394 9413.006.1-F_at C9orf61 NM_004816 9q13-q21 9413.006.1 4915.012.1 9413.6 7373.8
395 59.023.2-B_at ACTA2 NM_001613 10q23.3 59.023.2 501.006.1 59.23 4744.4
396 72.005.1-B_at ACTG2 NM_001615 2p13.1 72.005.1 51062.008.1 72.5 8404.15
397 4915.011.1-C_at NTRK2 NM_001007104 9q22.1 4915.011.1 51201.005.1 4915.11 4281.14
398 27122.018.1- DKK3 NM_001018066 11p15.2 27122.018.1 51201.007.1 27122.18 4288.6
F_at
399 3852.006.1-B_at KRT5 NM_000424 12q12-q13 3852.006.1 51203.002.2 3852.6 25925.9
400 4638.006.2-D_at MYLK NM_005975 3q21 4638.006.2 51203.003.1 4638.6 667.10
401 7153.005.1-E_at TOP2A NM_001067 17q21-q22 7153.005.1 51203.004.1 7153.5 57447.11
402 7373.001.2-T_at COL14A1 NM_021110 8q23 7373.001.2 51203.009.1 7373.1 8404.24
403 7018.026.1-B_at TF NM_001063 3q22.1 7018.026.1 5137.004.2 7018.26 57447.32
404 7402.014.1-B_at UTRN NM_007124 6q24 7402.014.1 5156.001.1 7402.14 51062.8
405 57447.010.3- NDRG2 NM_016264 14q11.2 57447.010.3 5156.005.1 57447.10 2335.13
D_at
406 140446.004.1-T 140446.004.1 5213.024.1 140446.4 7170.5
407 59.026.2-T_at ACTA2 NM_001613 10q23.3 59.026.2 5284.001.1 59.26 2568.3
408 59.038.1-B_at ACTA2 NM_001613 10q23.3 59.038.1 5284.003.1 59.38 9898.15
409 4240.009.1-C_at MFGE8 NM_005928 15q25 4240.009.1 5284.003.2 4240.9 7018.13
410 57447.030.1- NDRG2 NM_016265 14q11.2 57447.030.1 5284.004.1 57447.30 7170.34
F_at
411 9768.004.1-B_at KIAA0101 NM_001029990 15q22.31 9768.004.1 5288.001.1 9768.4 2.2
412 57447.008.1- NDRG2 NM_016266 14q11.2 57447.008.1 5288.001.2 57447.8 57447.50
T_at
413 59.014.2-T_at ACTA2 NM_001613 10q23.3 59.014.2 5288.001.3 59.14 2335.32
414 4915.012.1-T_at NTRK2 NM_001007105 9q22.1 4915.012.1 5288.003.1 4915.12 51203.3
415 3866.004.1-T_at KRT15 NM_002275 17q21.2 3866.004.1 5311.002.1 3866.4 9493.1
416 2582.007.2-C_at GALE NM_000403 1p36-p35 2582.007.2 5311.003.1 2582.7 80034.3
417 7153.002.5-T_at TOP2A NM_001067 17q21-q22 7153.002.5 53335.002.1 7153.2 7170.16
418 4638.009.1-T_at MYLK NM_005976 3q21 4638.009.1 53829.001.2 4638.9 57447.26
419 3861.023.1-T_at KRT14 NM_000526 17q12-q21 3861.023.1 54443.006.2 3861.23 301.8
420 5858.003.3-C_at PZP NM_002864 12p13-p12.2 5858.003.3 54443.011.1 5858.3 80034.2
421 3861.020.1-F_at KRT14 NM_000526 17q12-q21 3861.020.1 54443.012.1 3861.20 3852.23
422 147495.005.1-T APCDD1 NM_153000 18p11.22 147495.005.1 54443.013.1 147495.5 10124.3
423 4638.006.2-C_at MYLK NM_005977 3q21 4638.006.2 54829.001.1 4638.6 23650.19
424 1308.004.1-F_at COL17A1 NM_000504 10q24.3 1308.004.1 54928.003.1 1308.4 7170.27
425 4915.004.1-F_at NTRK2 NM_001007106 9q22.1 4915.004.1 54997.002.2 4915.4 54928.3
426 3866.008.1-B_at KRT15 NM_002275 17q21.2 3866.008.1 55107.006.2 3866.8 3084.10
427 8626.002.1-E_at TP63 NM_003722 3q28 8626.002.1 55366.001.1 8626.2 2115.3
428 1264.003.1-T_at CNN1 NM_001299 19p13.2-p13.1 1264.003.1 55366.001.2 1264.3 8404.9
429 59.042.1-F_at ACTA2 NM_001613 10q23.3 59.042.1 55656.007.3 59.42 6289.3
430 4833.004.1-C_at NME4 NM_005009 16p13.3 4833.004.1 55732.003.2 4833.4 7170.25
431 2568.006.1-B_at GABRP NM_014211 5q33-q34 2568.006.1 5608.002.1 2568.6 22974.7
432 57447.004.2- NDRG2 NM_016267 14q11.2 57447.004.2 5608.004.1 57447.4 4147.11
T_at
433 59.014.2-B_at ACTA2 NM_001613 10q23.3 59.014.2 5621.002.2 59.14 23650.3
434 3084.012.1-T_at NRG1 NM_004506 8p12 3084.012.1 5621.008.1 3084.12 64168.10
435 27122.017.1- DKK3 NM_001018067 11p15.2 27122.017.1 5627.002.1 27122.17 25925.11
T_at
436 3852.012.2-T_at KRT5 NM_000424 12q12-q13 3852.012.2 56477.001.1 3852.12 9232.4
437 59.033.1-T_at ACTA2 NM_001613 10q23.3 59.033.1 57162.010.1 59.33 4147.5
438 27122.002.1- DKK3 NM_001018068 11p15.2 27122.002.1 57447.002.1 27122.2 147804.4
C_at
439 3880.011.1-B_at KRT19 NM_002276 17q21.2 3880.011.1 57447.004.1 3880.11 81704.13
440 65983.013.1- GRAMD3 NM_023927 5q23.2 65983.013.1 57447.004.2 65983.13 54443.13
T_at
441 3872.014.1-T_at KRT17 NM_000422 17q12-q21 3872.014.1 57447.006.1 3872.14 1410.5
442 162605.001.4-C KRT28 NM_181535 17q21.2 162605.001.4 57447.008.1 162605.1 3204.1
443 59.031.2-B_at ACTA2 NM_001613 10q23.3 59.031.2 57447.008.2 59.31 29997.12
444 3084.012.2-B_at NRG1 NM_004507 8p12 3084.012.2 57447.009.1 3084.12 2.5
445 5858.001.2-C_at PZP NM_002864 12p13-p12.2 5858.001.2 57447.010.1 5858.1 1063.2
446 65983.010.1- GRAMD3 NM_023927 5q23.2 65983.010.1 57447.010.2 65983.10 10144.21
T_at
447 7373.003.5-F_at COL14A1 NM_021110 8q23 7373.003.5 57447.010.3 7373.3 8404.25
448 3866.010.1-T_at KRT15 NM_002275 17q21.2 3866.010.1 57447.011.1 3866.10 6876.20
449 8404.005.1-B_at SPARCL1 NM_004684 4q22.1 8404.005.1 57447.012.1 8404.5 7170.6
450 3866.005.1-T_at KRT15 NM_002275 17q21.2 3866.005.1 57447.012.2 3866.5 10051.16
451 59.003.1-F_at ACTA2 NM_001613 10q23.3 59.003.1 57447.017.1 59.3 5627.2
452 7153.002.5-F_at TOP2A NM_001067 17q21-q22 7153.002.5 57447.021.1 7153.2 399687.1
453 2487.001.1-T_at FRZB NM_001463 2qter 2487.001.1 57447.022.1 2487.1 54997.2
454 3866.010.1-B_at KRT15 NM_002275 17q21.2 3866.010.1 57447.024.1 3866.10 57561.1
455 147495.009.1-T APCDD1 NM_153000 18p11.22 147495.009.1 57447.025.1 147495.9 8404.31
456 65983.003.2- GRAMD3 NM_023927 5q23.2 65983.003.2 57447.025.2 65983.3 2.25
T_at
457 59.040.1-D_at ACTA2 NM_001613 10q23.3 59.040.1 57447.026.1 59.40 699.2
458 59.024.2-T_at ACTA2 NM_001613 10q23.3 59.024.2 57447.027.1 59.24 9055.13
459 1717.009.2-B_at DHCR7 NM_001360 11q13.2-q13.5 1717.009.2 57447.028.1 1717.9 10051.5
460 1756.027.1-F_at DMD NM_000142 Xp21.2 1756.027.1 57447.029.1 1756.27 2568.2
461 59.042.1-B_at ACTA2 NM_001613 10q23.3 59.042.1 57447.030.1 59.42 4147.4
462 7153.002.5-D_at TOP2A NM_001067 17q21-q22 7153.002.5 57447.031.1 7153.2 2938.1
463 57447.031.1- NDRG2 NM_016268 14q11.2 57447.031.1 57447.032.1 57447.31 2982.12
F_at
464 140885.011.1-C SIRPA NM_001040023 20p13 140885.011.1 57447.033.1 140885.11 2893.2
465 59.003.1-T_at ACTA2 NM_001613 10q23.3 59.003.1 57447.034.1 59.3 116369.6
466 3832.002.1-D_at KIF11 NM_004523 10q24.1 3832.002.1 57447.035.1 3832.2 6304.7
467 3880.005.1-D_at KRT19 NM_002276 17q21.2 3880.005.1 57447.037.1 3880.5 2335.35
468 3084.012.1-F_at NRG1 NM_004508 8p12 3084.012.1 57447.038.1 3084.12 4751.2
469 6595.012.1-B_at SMARCA2 NM_003070 9p22.3 6595.012.1 57447.039.1 6595.12 64151.1
470 59.012.2-D_at ACTA2 NM_001613 10q23.3 59.012.2 57447.040.1 59.12 29089.3
471 57447.034.1- NDRG2 NM_016269 14q11.2 57447.034.1 57447.041.1 57447.34 3860.8
C_at
472 56477.001.1- CCL28 NM_148672 5p12 56477.001.1 57447.042.1 56477.1 25925.6
B_at
473 57447.041.1- NDRG2 NM_016270 14q11.2 57447.041.1 57447.043.1 57447.41 59.49
D_at
474 9768.005.1-B_at KIAA0101 NM_001029991 15q22.31 9768.005.1 57447.044.1 9768.5 6289.2
475 285203.001.2-C C3orf64 NM_173654 3p14.1 285203.001.2 57447.047.1 285203.1 244.3
476 147495.006.1-B APCDD1 NM_153000 18p11.22 147495.006.1 57447.048.1 147495.6 11065.8
477 7018.029.1-D_at TF NM_001063 3q22.1 7018.029.1 57447.048.2 7018.29 7091.6
478 3852.009.1-T_at KRT5 NM_000424 12q12-q13 3852.009.1 57447.049.1 3852.9 79608.9
479 59.023.2-D_at ACTA2 NM_001613 10q23.3 59.023.2 57447.050.1 59.23 9413.2
480 1959.002.1-D_at EGR2 NM_000399 10q21.1 1959.002.1 57447.051.1 1959.2 7431.64
481 7018.014.1-D_at TF NM_001063 3q22.1 7018.014.1 57447.051.2 7018.14 8404.29
482 5858.004.1-F_at PZP NM_002864 12p13-p12.2 5858.004.1 57451.001.3 5858.4 301.5
483 79192.002.2- IRX1 NM_024337 5p15.3 79192.002.2 57451.002.3 79192.2 9055.14
D_at
484 59.008.2-B_at ACTA2 NM_001613 10q23.3 59.008.2 57451.004.1 59.8 4281.23
485 8404.008.1-E_at SPARCL1 NM_004684 4q22.1 8404.008.1 57561.001.1 8404.8 1062.1
486 59.008.1-F_at ACTA2 NM_001613 10q23.3 59.008.1 57561.002.1 59.8 5858.5
487 4240.011.1-B_at MFGE8 NM_005928 15q25 4240.011.1 5764.001.1 4240.11 51201.7
488 94274.002.1- PPP1R14A NM_033256 19q13.1 94274.002.1 5803.002.1 94274.2 4240.1
C_at
489 4638.015.1-T_at MYLK NM_005978 3q21 4638.015.1 5803.002.2 4638.15 9413.1
490 6376.001.1-T_at CX3CL1 NM_002996 16q13 6376.001.1 5803.006.1 6376.1 11197.1
491 57447.043.1- NDRG2 NM_016271 14q11.2 57447.043.1 58499.005.2 57447.43 6285.2
F_at
492 59.039.1-T_at ACTA2 NM_001613 10q23.3 59.039.1 5858.001.2 59.39 7169.1
493 4638.006.1-B_at MYLK NM_005979 3q21 4638.006.1 5858.003.3 4638.6 4601.14
494 25802.003.1- LMOD1 NM_012134 1q32 25802.003.1 5858.004.1 25802.3 51203.2
F_at
495 57447.025.1- NDRG2 NM_016272 14q11.2 57447.025.1 5858.005.1 57447.25 7018.22
T_at
496 57447.017.1- NDRG2 NM_016273 14q11.2 57447.017.1 59.003.1 57447.17 4288.9
T_at
497 7018.026.1-C_at TF NM_001063 3q22.1 7018.026.1 59.004.1 7018.26 8321.4
498 7018.028.1-E_at TF NM_001063 3q22.1 7018.028.1 59.004.2 7018.28 8564.4
499 4915.008.1-C_at NTRK2 NM_001007107 9q22.1 4915.008.1 59.008.1 4915.8 29127.13
500 358.018.1-C_at AQP1 NM_198098 7p14 358.018.1 59.008.2 358.18 1058.4
501 7153.002.6-B_at TOP2A NM_001067 17q21-q22 7153.002.6 59.009.1 7153.2 2232.14
502 57447.012.1- NDRG2 NM_016274 14q11.2 57447.012.1 59.012.1 57447.12 23650.5
T_at
503 59.040.1-B_at ACTA2 NM_001613 10q23.3 59.040.1 59.012.2 59.40 5621.2
504 57447.006.1- NDRG2 NM_016275 14q11.2 57447.006.1 59.014.1 57447.6 54443.12
T_at
505 9493.006.1-F_at KIF23 NM_004856 15q23 9493.006.1 59.014.2 9493.6 3479.3
506 57447.004.1- NDRG2 NM_016276 14q11.2 57447.004.1 59.015.1 57447.4 94274.3
T_at
507 57447.004.2- NDRG2 NM_016277 14q11.2 57447.004.2 59.015.2 57447.4 84668.3
B_at
508 7373.001.2-D_at COL14A1 NM_021110 8q23 7373.001.2 59.016.1 7373.1 22974.8
509 9493.004.1-B_at KIF23 NM_004856 15q23 9493.004.1 59.022.1 9493.4 55656.7
510 2568.005.2-C_at GABRP NM_014211 5q33-q34 2568.005.2 59.022.2 2568.5 29127.2
511 7018.029.1-F_at TF NM_001063 3q22.1 7018.029.1 59.023.1 7018.29 4281.12
512 26289.013.1- AK5 NM_012116 1p31 26289.013.1 59.023.2 26289.13 79627.3
B_at
513 7169.015.1-B_at TPM2 NM_003289 9p13.2-p13.1 7169.015.1 59.024.1 7169.15 2982.14
514 57451.001.3- ODZ2 NM_001080428 5q34-q35.1 57451.001.3 59.024.2 57451.1 2335.53
F_at
515 2568.005.2-F_at GABRP NM_014211 5q33-q34 2568.005.2 59.026.1 2568.5 667.1
516 57447.004.2- NDRG2 NM_016278 14q11.2 57447.004.2 59.026.2 57447.4 55366.1
F_at
517 8404.004.1-D_at SPARCL1 NM_004684 4q22.1 8404.004.1 59.029.1 8404.4 5311.3
518 3855.004.2-D_at KRT7 NM_005556 12q12-q13 3855.004.2 59.031.1 3855.4 6304.11
519 3872.014.1-F_at KRT17 NM_000422 17q12-q21 3872.014.1 59.031.2 3872.14 7373.7
520 57447.033.1- NDRG2 NM_016279 14q11.2 57447.033.1 59.033.1 57447.33 1410.9
F_at
521 9452.001.1-T_at ITM2A NM_004867 Xq13.3-Xq21.2 9452.001.1 59.033.2 9452.1 79745.4
522 59.033.2-T_at ACTA2 NM_001613 10q23.3 59.033.2 59.034.1 59.33 24137.4
523 3084.009.1-T_at NRG1 NM_004509 8p12 3084.009.1 59.034.2 3084.9 6241.13
524 57447.040.1- NDRG2 NM_016280 14q11.2 57447.040.1 59.038.1 57447.40 1410.1
T_at
525 4833.004.1-T_at NME4 NM_005009 16p13.3 4833.004.1 59.039.1 4833.4 4781.15
526 3426.001.1-F_at CFI NM_000204 4q25 3426.001.1 59.040.1 3426.1 72.2
527 59.034.1-B_at ACTA2 NM_001613 10q23.3 59.034.1 59.042.1 59.34 2982.13
528 10253.001.1- SPRY2 NM_005842 13q31.1 10253.001.1 59.049.1 10253.1 79971.12
E_at
529 9073.001.1-C_at CLDN8 NM_199328 21q22.11 9073.001.1 6122.037.1 9073.1 7169.4
530 51201.005.1- ZDHHC2 NM_016353 8p21.3-p22 51201.005.1 6122.046.1 51201.5 2335.16
T_at
531 9477.006.1-C_at MED20 NM_004275 6p21.1 9477.006.1 6241.013.1 9477.6 259266.3
532 57447.028.1- NDRG2 NM_016281 14q11.2 57447.028.1 6285.001.1 57447.28 9055.20
T_at
533 25925.007.1- ZNF521 NM_015461 18q11.2 25925.007.1 6285.002.1 25925.7 7091.16
T_at
534 59.024.2-B_at ACTA2 NM_001613 10q23.3 59.024.2 6285.003.1 59.24 57162.10
535 2.022.1-T_at A2M NM_000014 12p13.3-p12.3 2.022.1 6286.001.1 2.22 4781.2
536 4281.008.2-B_at MID1 NM_000382 Xp22 4281.008.2 6288.001.1 4281.8 6122.37
537 90231.001.1- KIAA2013 NM_138346 1p36.22 90231.001.1 6288.004.1 90231.1 4240.15
C_at
538 358.012.1-D_at AQP1 NM_198098 7p14 358.012.1 6289.001.1 358.12 6304.2
539 3852.021.1-T_at KRT5 NM_000424 12q12-q13 3852.021.1 6289.001.2 3852.21 301.13
540 7373.003.4-D_at COL14A1 NM_021110 8q23 7373.003.4 6289.002.1 7373.3 6304.12
541 57447.048.1- NDRG2 NM_016282 14q11.2 57447.048.1 6289.002.2 57447.48 11065.5
T_at
542 358.012.1-B_at AQP1 NM_198098 7p14 358.012.1 6289.003.1 358.12 29997.16
543 7018.025.1-C_at TF NM_001063 3q22.1 7018.025.1 6289.003.2 7018.25 1410.11
544 5608.004.1-T_at MAP2K6 NM_002758 17q24.3 5608.004.1 6289.005.1 5608.4 7170.40
545 3084.012.2-F_at NRG1 NM_004510 8p12 3084.012.2 6289.006.1 3084.12 7170.41
546 4306.002.1-C_at NR3C2 NM_000901 4q31.1 4306.002.1 6304.002.1 4306.2 4094.2
547 4288.004.1-D_at MKI67 NM_002417 10q25-qter 4288.004.1 6304.006.2 4288.4 7113.11
548 57447.002.1- NDRG2 NM_016283 14q11.2 57447.002.1 6304.007.1 57447.2 7170.2
F_at
549 4281.018.1-T_at MID1 NM_000383 Xp22 4281.018.1 6304.007.2 4281.18 8404.17
550 10144.020.2- FAM13A1 NM_001015045 4q22.1 10144.020.2 6304.011.1 10144.20 59.29
B_at
551 6876.016.1-E_at TAGLN NM_001001522 11q23.2 6876.016.1 6304.012.1 6876.16 29089.1
552 57447.008.2- NDRG2 NM_016284 14q11.2 57447.008.2 6376.001.1 57447.8 9134.1
T_at
553 51203.004.1- NUSAP1 NM_016359 15q15.1 51203.004.1 6376.001.2 51203.4 1410.10
T_at
554 2335.028.1-B_at FN1 NM_002026 2q34 2335.028.1 64151.001.2 2335.28 2327.3
555 7018.028.1-F_at TF NM_001063 3q22.1 7018.028.1 64168.010.1 7018.28 6289.1
556 7373.003.5-T_at COL14A1 NM_021110 8q23 7373.003.5 6422.001.1 7373.3 1410.6
557 81557.006.1- MAGED4B NM_030801 — 81557.006.1 6422.002.1 81557.6 80034.4
C_at
558 3866.002.1-D_at KRT15 NM_002275 17q21.2 3866.002.1 6441.004.1 3866.2 1410.8
559 3866.001.1-B_at KRT15 NM_002275 17q21.2 3866.001.1 6595.012.1 3866.1 6288.1
560 55107.006.2- TMEM16A NM_018043 11q13.3 55107.006.2 65983.003.1 55107.6 8404.20
T_at
561 79068.010.1- FTO NM_001080432 16q12.2 79068.010.1 65983.003.2 79068.10 3459.5
D_at
562 57447.009.1- NDRG2 NM_016285 14q11.2 57447.009.1 65983.004.1 57447.9 83539.1
T_at
563 2115.015.1-T_at ETV1 NM_004956 7p21.3 2115.015.1 65983.004.2 2115.15 6288.4
564 1756.013.1-C_at DMD NM_000143 Xp21.2 1756.013.1 65983.005.1 1756.13 4781.16
565 7169.015.1-F_at TPM2 NM_003290 9p13.2-p13.1 7169.015.1 65983.007.1 7169.15 53829.1
566 65983.013.2- GRAMD3 NM_023927 5q23.2 65983.013.2 65983.008.1 65983.13 10051.8
F_at
567 8404.001.1-B_at SPARCL1 NM_004684 4q22.1 8404.001.1 65983.009.1 8404.1 1033.2
568 4240.004.1-B_at MFGE8 NM_005928 15q25 4240.004.1 65983.010.1 4240.4 2335.5
569 57447.012.2- NDRG2 NM_016286 14q11.2 57447.012.2 65983.013.1 57447.12 7113.9
T_at
570 57447.024.1- NDRG2 NM_016287 14q11.2 57447.024.1 65983.013.2 57447.24 7168.3
F_at
571 358.018.1-T_at AQP1 NM_198098 7p14 358.018.1 667.001.1 358.18 79608.1
572 57447.048.2- NDRG2 NM_016288 14q11.2 57447.048.2 667.010.1 57447.48 7113.10
T_at
573 59.031.1-C_at ACTA2 NM_001613 10q23.3 59.031.1 667.021.1 59.31 4781.14
574 3860.007.1-F_at KRT13 NM_002275 17q12-q21.2 3860.007.1 667.022.1 3860.7 11065.3
575 8404.028.1-C_at SPARCL1 NM_004684 4q22.1 8404.028.1 6876.002.1 8404.28 3084.5
576 4240.011.3-E_at MFGE8 NM_005928 15q25 4240.011.3 6876.011.1 4240.11 6285.3
577 59.022.2-B_at ACTA2 NM_001613 10q23.3 59.022.2 6876.016.1 59.22 54829.1
578 3866.002.1-F_at KRT15 NM_002275 17q21.2 3866.002.1 6876.016.2 3866.2 9055.11
579 3866.002.1-T_at KRT15 NM_002275 17q21.2 3866.002.1 6876.020.1 3866.2 4288.8
580 4915.005.1-B_at NTRK2 NM_001007108 9q22.1 4915.005.1 6876.023.1 4915.5 4781.7
581 8404.008.1-F_at SPARCL1 NM_004684 4q22.1 8404.008.1 699.002.1 8404.8 9055.17
582 79608.002.1- RIC3 NM_024557 11p15.4 79608.002.1 7018.013.1 79608.2 7170.18
F_at
583 8404.023.1-D_at SPARCL1 NM_004684 4q22.1 8404.023.1 7018.014.1 8404.23 10253.3
584 3426.002.1-D_at CFI NM_000204 4q25 3426.002.1 7018.022.1 3426.2 2982.15
585 2335.027.1-T_at FN1 NM_002027 2q34 2335.027.1 7018.025.1 2335.27 10124.4
586 11065.009.1- UBE2C NM_007019 20q13.12 11065.009.1 7018.026.1 11065.9 7091.5
T_at
587 140885.013.1-F SIRPA NM_001040024 20p13 140885.013.1 7018.028.1 140885.13 501.6
588 57447.021.1- NDRG2 NM_016289 14q11.2 57447.021.1 7018.029.1 57447.21 244.12
B_at
589 25802.004.1- LMOD1 NM_012134 1q32 25802.004.1 7091.001.1 25802.4 3872.18
C_at
590 4638.014.1-F_at MYLK NM_005980 3q21 4638.014.1 7091.005.1 4638.14 10144.17
591 9493.004.1-F_at KIF23 NM_004856 15q23 9493.004.1 7091.006.1 9493.4 29127.7
592 8404.004.1-B_at SPARCL1 NM_004684 4q22.1 8404.004.1 7091.010.1 8404.4 10010.4
593 8404.004.2-T_at SPARCL1 NM_004684 4q22.1 8404.004.2 7091.014.1 8404.4 4781.6
594 57447.010.2- NDRG2 NM_016290 14q11.2 57447.010.2 7091.015.1 57447.10 23092.4
T_at
595 57447.010.3- NDRG2 NM_016291 14q11.2 57447.010.3 7091.016.1 57447.10 2335.2
B_at
596 27122.006.1- DKK3 NM_001018069 11p15.2 27122.006.1 7113.001.1 27122.6 6304.6
T_at
597 5156.005.1-T_at PDGFRA NM_006206 4q11-q13 5156.005.1 7113.009.1 5156.5 9055.19
598 5858.004.1-E_at PZP NM_002864 12p13-p12.2 5858.004.1 7113.010.1 5858.4 1398.1
599 25802.008.1- LMOD1 NM_012134 1q32 25802.008.1 7113.011.1 25802.8 339965.1
D_at
600 2327.002.2-T_at FMO2 NM_001460 1q23-q25 2327.002.2 7153.002.2 2327.2 7113.1
601 3852.004.1-C_at KRT5 NM_000424 12q12-q13 3852.004.1 7153.002.3 3852.4 4833.10
602 59.026.2-F_at ACTA2 NM_001613 10q23.3 59.026.2 7153.002.4 59.26 79971.13
603 57447.029.1- NDRG2 NM_016292 14q11.2 57447.029.1 7153.002.5 57447.29 152015.5
C_at
604 7169.022.1-D_at TPM2 NM_003291 9p13.2-p13.1 7169.022.1 7153.002.6 7169.22 4288.5
605 23266.001.3- LPHN2 NM_012302 1p31.1 23266.001.3 7153.005.1 23266.1 6441.4
B_at
606 3084.012.1-B_at NRG1 NM_004511 8p12 3084.012.1 7168.003.1 3084.12 6122.46
607 29127.019.2- RACGAP1 NM_013277 12q13.13 29127.019.2 7169.001.1 29127.19 115908.2
T_at
608 10253.004.1- SPRY2 NM_005842 13q31.1 10253.004.1 7169.004.1 10253.4 9481.1
T_at
609 10124.002.1- ARL4A NM_001037164 7p21-p15.3 10124.002.1 7169.015.1 10124.2 2335.24
D_at
610 3861.013.1-D_at KRT14 NM_000526 17q12-q21 3861.013.1 7169.022.1 3861.13 891.7
611 8404.032.1-T_at SPARCL1 NM_004684 4q22.1 8404.032.1 7170.002.1 8404.32 57451.4
612 84441.002.1- MAML2 NM_032427 11q21 84441.002.1 7170.005.2 84441.2 6286.1
E_at
613 2.013.1-E_at A2M NM_000014 12p13.3-p12.3 2.013.1 7170.006.1 2.13 10580.12
614 3084.004.1-T_at NRG1 NM_004512 8p12 3084.004.1 7170.007.1 3084.4 23321.14
615 5288.001.2-F_at PIK3C2G NM_004570 12p12 5288.001.2 7170.014.1 5288.1 2824.1
616 57447.017.1- NDRG2 NM_016293 14q11.2 57447.017.1 7170.016.3 57447.17 29127.22
F_at
617 3084.006.1-T_at NRG1 NM_004513 8p12 3084.006.1 7170.018.2 3084.6 54443.11
618 59.039.1-F_at ACTA2 NM_001613 10q23.3 59.039.1 7170.025.1 59.39 29997.8
619 2.024.1-T_at A2M NM_000014 12p13.3-p12.3 2.024.1 7170.027.1 2.24 57561.2
620 3815.002.2-E_at KIT NM_000236 4q11-q12 3815.002.2 7170.034.2 3815.2 57451.2
621 1756.009.1-D_at DMD NM_000144 Xp21.2 1756.009.1 7170.040.1 1756.9 5213.24
622 7091.014.1-B_at TLE4 NM_007005 9q21.31 7091.014.1 7170.041.1 7091.14 11065.4
623 4629.015.1-F_at MYH11 NM_001040137 16p13.11 4629.015.1 72.001.1 4629.15 6289.6
624 59.008.2-F_at ACTA2 NM_001613 10q23.3 59.008.2 72.002.1 59.8 23284.7
625 2568.005.2-T_at GABRP NM_014211 5q33-q34 2568.005.2 72.005.1 2568.5 79971.9
626 115207.002.1-T KCTD12 NM_138444 13q22.3 115207.002.1 7373.001.1 115207.2 51203.9
627 4281.001.1-T_at MID1 NM_000384 Xp22 4281.001.1 7373.001.2 4281.1 1308.2
628 84668.002.2- FAM126A NM_032581 7p15.3 84668.002.2 7373.002.1 84668.2 4288.7
T_at
629 4240.004.1-F_at MFGE8 NM_005928 15q25 4240.004.1 7373.003.1 4240.4 244.11
630 8404.005.1-D_at SPARCL1 NM_004684 4q22.1 8404.005.1 7373.003.2 8404.5 3178.3
631 8404.032.1-B_at SPARCL1 NM_004684 4q22.1 8404.032.1 7373.003.3 8404.32 9055.12
632 57447.044.1- NDRG2 NM_016294 14q11.2 57447.044.1 7373.003.4 57447.44 9232.1
E_at
633 8626.006.2-F_at TP63 NM_003722 3q28 8626.006.2 7373.003.5 8626.6 79068.11
634 57447.051.2- NDRG2 NM_016295 14q11.2 57447.051.2 7373.003.6 57447.51 7534.1
B_at
635 1063.001.1-T_at CENPF NM_016343 1q32-q41 1063.001.1 7373.004.1 1063.1 79971.14
636 3426.002.1-T_at CFI NM_000204 4q25 3426.002.1 7373.007.1 3426.2 5621.8
637 1308.001.1-T_at COL17A1 NM_000505 10q24.3 1308.001.1 7373.008.1 1308.1 55732.3
638 389432.002.1-F SAMD5 NM_001030060 6q24.3 389432.002.1 7402.014.1 389432.2 221120.6
639 57447.017.1- NDRG2 NM_016296 14q11.2 57447.017.1 7431.064.1 57447.17 2335.45
B_at
640 2115.014.1-F_at ETV1 NM_004956 7p21.3 2115.014.1 7534.001.1 2115.14 7170.7
641 5284.004.1-T_at PIGR NM_002644 1q31-q41 5284.004.1 79068.010.1 5284.4 9055.10
642 57447.029.1- NDRG2 NM_016297 14q11.2 57447.029.1 79068.011.2 57447.29 58499.5
F_at
643 8626.006.1-F_at TP63 NM_003722 3q28 8626.006.1 79192.002.2 8626.6 54443.6
644 2982.002.1-C_at GUCY1A3 NM_000856 4q31.3-q33| 2982.002.1 79608.001.1 2982.2 59.16
4q31.1-q31.2
645 57447.047.1- NDRG2 NM_016298 14q11.2 57447.047.1 79608.002.1 57447.47 7170.14
T_at
646 5803.006.1-E_at PTPRZ1 NM_002851 7q31.3 5803.006.1 79608.008.1 5803.6
647 57447.021.1- NDRG2 NM_016299 14q11.2 57447.021.1 79608.008.2 57447.21
F_at
648 57447.039.1- NDRG2 NM_016300 14q11.2 57447.039.1 79608.009.1 57447.39 205 genes
F_at
649 4281.008.2-F_at MID1 NM_000385 Xp22 4281.008.2 79627.003.1 4281.8 645
transcrits
650 57447.029.1- NDRG2 NM_016301 14q11.2 57447.029.1 79745.004.3 57447.29 1228
D_at probesets
651 65983.013.1- GRAMD3 NM_023927 5q23.2 65983.013.1 79895.001.1 65983.13
B_at
652 5284.004.1-E_at PIGR NM_002644 1q31-q41 5284.004.1 79937.001.1 5284.4
653 4240.011.1-D_at MFGE8 NM_005928 15q25 4240.011.1 79937.002.1 4240.11
654 57447.024.1- NDRG2 NM_016302 14q11.2 57447.024.1 79971.009.1 57447.24
T_at
655 6876.011.1-B_at TAGLN NM_001001523 11q23.2 6876.011.1 79971.012.1 6876.11
656 7373.003.2-T_at COL14A1 NM_021110 8q23 7373.003.2 79971.013.2 7373.3
657 3852.014.1-D_at KRT5 NM_000424 12q12-q13 3852.014.1 79971.014.1 3852.14
658 4915.005.1-D_at NTRK2 NM_001007109 9q22.1 4915.005.1 80034.002.2 4915.5
659 9768.002.2-B_at KIAA0101 NM_001029992 15q22.31 9768.002.2 80034.003.4 9768.2
660 140885.010.1-D SIRPA NM_001040025 20p13 140885.010.1 80034.004.1 140885.10
661 4638.020.1-E_at MYLK NM_005981 3q21 4638.020.1 81557.006.1 4638.20
662 57447.017.1- NDRG2 NM_016303 14q11.2 57447.017.1 81704.008.1 57447.17
C_at
663 7373.004.1-T_at COL14A1 NM_021110 8q23 7373.004.1 81704.013.1 7373.4
664 3852.008.2-E_at KRT5 NM_000424 12q12-q13 3852.008.2 8321.004.1 3852.8
665 4281.015.1-E_at MID1 NM_000386 Xp22 4281.015.1 83539.001.1 4281.15
666 8404.013.1-C_at SPARCL1 NM_004684 4q22.1 8404.013.1 8404.001.1 8404.13
667 90293.001.3- KLHL13 NM_033495 Xq23-q24 90293.001.3 8404.002.1 90293.1
T_at
668 57447.044.1- NDRG2 NM_016304 14q11.2 57447.044.1 8404.004.1 57447.44
T_at
669 23650.011.2- TRIM29 NM_012101 11q22-q23 23650.011.2 8404.004.2 23650.11
D_at
670 2335.006.1-D_at FN1 NM_002028 2q34 2335.006.1 8404.005.1 2335.6
671 57447.022.1- NDRG2 NM_016305 14q11.2 57447.022.1 8404.008.1 57447.22
T_at
672 8404.032.1-D_at SPARCL1 NM_004684 4q22.1 8404.032.1 8404.009.1 8404.32
673 8404.030.1-F_at SPARCL1 NM_004684 4q22.1 8404.030.1 8404.013.1 8404.30
674 5803.002.2-T_at PTPRZ1 NM_002851 7q31.3 5803.002.2 8404.015.1 5803.2
675 8404.004.2-C_at SPARCL1 NM_004684 4q22.1 8404.004.2 8404.017.1 8404.4
676 84441.005.1- MAML2 NM_032427 11q21 84441.005.1 8404.017.2 84441.5
C_at
677 7091.015.1-F_at TLE4 NM_007005 9q21.31 7091.015.1 8404.020.1 7091.15
678 2119.005.1-D_at ETV5 NM_004454 3q28 2119.005.1 8404.021.1 2119.5
679 7373.003.6-F_at COL14A1 NM_021110 8q23 7373.003.6 8404.022.1 7373.3
680 79608.008.1- RIC3 NM_024557 11p15.4 79608.008.1 8404.023.1 79608.8
T_at
681 3852.008.1-T_at KRT5 NM_000424 12q12-q13 3852.008.1 8404.024.1 3852.8
682 8626.007.1-T_at TP63 NM_003722 3q28 8626.007.1 8404.025.1 8626.7
683 8404.022.1-T_at SPARCL1 NM_004684 4q22.1 8404.022.1 8404.026.1 8404.22
684 8404.034.1-T_at SPARCL1 NM_004684 4q22.1 8404.034.1 8404.028.1 8404.34
685 57447.049.1- NDRG2 NM_016306 14q11.2 57447.049.1 8404.028.3 57447.49
T_at
686 5311.002.1-B_at PKD2 NM_000297 4q21-q23 5311.002.1 8404.029.1 5311.2
687 2335.025.3-T_at FN1 NM_002029 2q34 2335.025.3 8404.030.1 2335.25
688 4147.012.1-T_at MATN2 NM_002380 8q22 4147.012.1 8404.031.1 4147.12
689 301.015.1-T_at ANXA1 NM_000700 9q12-q21.2| 301.015.1 8404.032.1 301.15
9q12-q21.2
690 301.004.1-T_at ANXA1 NM_000700 9q12-q21.2| 301.004.1 8404.034.1 301.4
9q12-q21.2
691 3426.002.2-F_at CFI NM_000204 4q25 3426.002.2 8404.035.1 3426.2
692 7091.001.1-C_at TLE4 NM_007005 9q21.31 7091.001.1 84417.001.1 7091.1
693 8404.021.1-D_at SPARCL1 NM_004684 4q22.1 8404.021.1 84417.001.2 8404.21
694 7153.002.3-B_at TOP2A NM_001067 17q21-q22 7153.002.3 84441.002.1 7153.2
695 53335.002.1- BCL11A NM_018014 2p16.1 53335.002.1 84441.005.1 53335.2
E_at
696 5284.003.2-T_at PIGR NM_002644 1q31-q41 5284.003.2 84668.002.1 5284.3
697 4306.002.1-F_at NR3C2 NM_000901 4q31.1 4306.002.1 84668.002.2 4306.2
698 5284.003.2-D_at PIGR NM_002644 1q31-q41 5284.003.2 84668.003.1 5284.3
699 5803.002.1-T_at PTPRZ1 NM_002851 7q31.3 5803.002.1 84668.004.1 5803.2
700 10253.004.1- SPRY2 NM_005842 13q31.1 10253.004.1 8564.004.1 10253.4
E_at
701 23650.020.1- TRIM29 NM_012101 11q22-q23 23650.020.1 8626.002.1 23650.20
T_at
702 57447.042.1- NDRG2 NM_016307 14q11.2 57447.042.1 8626.005.1 57447.42
T_at
703 6876.023.1-F_at TAGLN NM_001001524 11q23.2 6876.023.1 8626.006.1 6876.23
704 7169.015.1-C_at TPM2 NM_003292 9p13.2-p13.1 7169.015.1 8626.006.2 7169.15
705 7153.002.4-F_at TOP2A NM_001067 17q21-q22 7153.002.4 8626.007.1 7153.2
706 4629.016.1-B_at MYH11 NM_001040138 16p13.11 4629.016.1 891.007.1 4629.16
707 6876.002.1-C_at TAGLN NM_001001525 11q23.2 6876.002.1 90231.001.1 6876.2
708 65983.007.1- GRAMD3 NM_023927 5q23.2 65983.007.1 90293.001.3 65983.7
T_at
709 7373.003.2-F_at COL14A1 NM_021110 8q23 7373.003.2 9055.010.1 7373.3
710 152015.004.1-T ROPN1B NM_001012337 3q21.2 152015.004.1 9055.011.1 152015.4
711 8404.004.2-B_at SPARCL1 NM_004684 4q22.1 8404.004.2 9055.012.1 8404.4
712 6285.001.1-B_at S100B NM_006272 21q22.3 6285.001.1 9055.013.1 6285.1
713 2115.007.1-E_at ETV1 NM_004956 7p21.3 2115.007.1 9055.014.1 2115.7
714 2.013.1-T_at A2M NM_000014 12p13.3-p12.3 2.013.1 9055.017.1 2.13
715 6289.005.1-T_at SAA2 NM_030754 11p15.1-p14 6289.005.1 9055.019.1 6289.5
716 9232.002.1-T_at PTTG1 NM_004219 5q35.1 9232.002.1 9055.020.1 9232.2
717 59.014.1-B_at ACTA2 NM_001613 10q23.3 59.014.1 9073.001.1 59.14
718 59.031.1-F_at ACTA2 NM_001613 10q23.3 59.031.1 90865.006.1 59.31
719 3084.011.1-T_at NRG1 NM_004514 8p12 3084.011.1 9134.001.1 3084.11
720 3872.005.1-F_at KRT17 NM_000422 17q12-q21 3872.005.1 9232.001.1 3872.5
721 3084.012.3-F_at NRG1 NM_004515 8p12 3084.012.3 9232.002.1 3084.12
722 81704.008.1- DOCK8 NM_203447 9p24.3 81704.008.1 9232.004.1 81704.8
F_at
723 140885.010.2-C SIRPA NM_001040026 20p13 140885.010.2 9413.001.1 140885.10
724 338707.006.1-E B4GALNT4 NM_178537 11p15.5 338707.006.1 9413.001.2 338707.6
725 23266.008.2- LPHN2 NM_012302 1p31.1 23266.008.2 9413.002.1 23266.8
T_at
726 120.005.2-E_at ADD3 NM_001121 10q24.2-q24.3 120.005.2 9413.003.1 120.5
727 4281.009.1-E_at MID1 NM_000387 Xp22 4281.009.1 9413.006.1 4281.9
728 4094.001.1-T_at MAF NM_001031804 16q22-q23 4094.001.1 94274.002.1 4094.1
729 2995.001.1-T_at GYPC NM_002101 2q14-q21 2995.001.1 94274.003.1 2995.1
730 4638.011.1-T_at MYLK NM_005982 3q21 4638.011.1 9452.001.1 4638.11
731 2335.017.1-T_at FN1 NM_002030 2q34 2335.017.1 9477.006.1 2335.17
732 5284.001.1-F_at PIGR NM_002644 1q31-q41 5284.001.1 9481.001.1 5284.1
733 8404.026.1-D_at SPARCL1 NM_004684 4q22.1 8404.026.1 9493.001.1 8404.26
734 2335.009.1-D_at FN1 NM_002031 2q34 2335.009.1 9493.004.1 2335.9
735 10461.002.2- MERTK NM_006343 2q14.1 10461.002.2 9493.006.1 10461.2
F_at
736 84441.002.1- MAML2 NM_032427 11q21 84441.002.1 9768.002.2 84441.2
T_at
737 147495.006.1-T APCDD1 NM_153000 18p11.22 147495.006.1 9768.004.1 147495.6
738 7091.010.1-B_at TLE4 NM_007005 9q21.31 7091.010.1 9768.005.1 7091.10
739 8404.008.1-C_at SPARCL1 NM_004684 4q22.1 8404.008.1 9898.015.2 8404.8
740 6376.001.2-C_at CX3CL1 NM_002996 16q13 6376.001.2 6376.1
741 3832.002.1-B_at KIF11 NM_004523 10q24.1 3832.002.1 3832.2
742 59.034.2-T_at ACTA2 NM_001613 10q23.3 59.034.2 59.34
743 147495.005.1-B APCDD1 NM_153000 18p11.22 147495.005.1 147495.5
744 3872.005.1-T_at KRT17 NM_000422 17q12-q21 3872.005.1 3872.5
745 79895.001.1- ATP8B4 NM_024837 15q21.2 79895.001.1 79895.1
D_at
746 57447.038.1- NDRG2 NM_016308 14q11.2 57447.038.1 57447.38
T_at
747 7373.008.1-T_at COL14A1 NM_021110 8q23 7373.008.1 7373.8
748 4744.004.1-C_at NEFH NM_021076 22q12.2 4744.004.1 4744.4
749 140885.010.1-T SIRPA NM_001040027 20p13 140885.010.1 140885.10
750 6876.016.2-E_at TAGLN NM_001001526 11q23.2 6876.016.2 6876.16
751 8404.015.1-T_at SPARCL1 NM_004684 4q22.1 8404.015.1 8404.15
752 4281.014.1-T_at MID1 NM_000388 Xp22 4281.014.1 4281.14
753 4288.006.1-F_at MKI67 NM_002417 10q25-qter 4288.006.1 4288.6
754 25925.009.1- ZNF521 NM_015461 18q11.2 25925.009.1 25925.9
E_at
755 4240.009.1-B_at MFGE8 NM_005928 15q25 4240.009.1 4240.9
756 667.010.1-E_at DST NM_001725 6p12.1 667.010.1 667.10
757 3866.005.1-B_at KRT15 NM_002275 17q21.2 3866.005.1 3866.5
758 57447.011.1- NDRG2 NM_016309 14q11.2 57447.011.1 57447.11
T_at
759 57447.034.1- NDRG2 NM_016310 14q11.2 57447.034.1 57447.34
B_at
760 25802.004.1- LMOD1 NM_012134 1q32 25802.004.1 25802.4
B_at
761 8404.024.1-T_at SPARCL1 NM_004684 4q22.1 8404.024.1 8404.24
762 57447.032.1- NDRG2 NM_016311 14q11.2 57447.032.1 57447.32
T_at
763 667.021.1-F_at DST NM_001726 6p12.1 667.021.1 667.21
764 5858.001.2-F_at PZP NM_002864 12p13-p12.2 5858.001.2 5858.1
765 51062.008.1- SPG3A NM_015915 14q22.1 51062.008.1 51062.8
T_at
766 2335.013.1-F_at FN1 NM_002032 2q34 2335.013.1 2335.13
767 2568.001.2-T_at GABRP NM_014211 5q33-q34 2568.001.2 2568.1
768 7170.005.2-D_at TPM3 NM_001043351 1q21.2 7170.005.2 7170.5
769 57447.034.1- NDRG2 NM_016312 14q11.2 57447.034.1 57447.34
F_at
770 7153.002.6-C_at TOP2A NM_001067 17q21-q22 7153.002.6 7153.2
771 2568.003.1-T_at GABRP NM_014211 5q33-q34 2568.003.1 2568.3
772 59.008.2-T_at ACTA2 NM_001613 10q23.3 59.008.2 59.8
773 9898.015.2-B_at UBAP2L NM_014847 1q21.3 9898.015.2 9898.15
774 7018.013.1-T_at TF NM_001063 3q22.1 7018.013.1 7018.13
775 7170.034.2-D_at TPM3 NM_001043352 1q21.2 7170.034.2 7170.34
776 3866.004.1-E_at KRT15 NM_002275 17q21.2 3866.004.1 3866.4
777 5284.001.1-T_at PIGR NM_002644 1q31-q41 5284.001.1 5284.1
778 2.002.1-C_at A2M NM_000014 12p13.3-p12.3 2.002.1 2.2
779 57447.050.1- NDRG2 NM_016313 14q11.2 57447.050.1 57447.50
T_at
780 7018.014.1-F_at TF NM_001063 3q22.1 7018.014.1 7018.14
781 2335.032.1-D_at FN1 NM_002033 2q34 2335.032.1 2335.32
782 3866.002.1-C_at KRT15 NM_002275 17q21.2 3866.002.1 3866.2
783 57447.043.1- NDRG2 NM_016314 14q11.2 57447.043.1 57447.43
T_at
784 51201.005.1- ZDHHC2 NM_016353 8p21.3-p22 51201.005.1 51201.5
D_at
785 51203.003.1- NUSAP1 NM_016360 15q15.1 51203.003.1 51203.3
T_at
786 9493.001.1-F_at KIF23 NM_004856 15q23 9493.001.1 9493.1
787 57447.024.1- NDRG2 NM_016315 14q11.2 57447.024.1 57447.24
B_at
788 80034.003.4- FAM130A2 NM_024969 2q24.3 80034.003.4 80034.3
B_at
789 7170.016.3-C_at TPM3 NM_001043353 1q21.2 7170.016.3 7170.16
790 65983.003.1- GRAMD3 NM_023927 5q23.2 65983.003.1 65983.3
T_at
791 57447.026.1- NDRG2 NM_016316 14q11.2 57447.026.1 57447.26
T_at
792 440421.001.1-F 440421.001.1 440421.1
793 301.008.1-D_at ANXA1 NM_000700 9q12-q21.2| 301.008.1 301.8
9q12-q21.2
794 80034.002.2- FAM130A2 NM_024969 2q24.3 80034.002.2 80034.2
T_at
795 7153.002.5-B_at TOP2A NM_001067 17q21-q22 7153.002.5 7153.2
796 3852.023.1-T_at KRT5 NM_000424 12q12-q13 3852.023.1 3852.23
797 8404.013.1-F_at SPARCL1 NM_004684 4q22.1 8404.013.1 8404.13
798 2.018.1-C_at A2M NM_000014 12p13.3-p12.3 2.018.1 2.18
799 10124.003.1- ARL4A NM_001037165 7p21-p15.3 10124.003.1 10124.3
B_at
800 3852.008.2-F_at KRT5 NM_000424 12q12-q13 3852.008.2 3852.8
801 4288.006.2-T_at MKI67 NM_002417 10q25-qter 4288.006.2 4288.6
802 8404.026.1-C_at SPARCL1 NM_004684 4q22.1 8404.026.1 8404.26
803 23650.019.1- TRIM29 NM_012101 11q22-q23 23650.019.1 23650.19
C_at
804 7170.027.1-T_at TPM3 NM_001043354 1q21.2 7170.027.1 7170.27
805 54928.003.1- IMPAD1 NM_017813 8q12.1 54928.003.1 54928.3
E_at
806 2335.025.1-B_at FN1 NM_002034 2q34 2335.025.1 2335.25
807 3084.010.1-T_at NRG1 NM_004516 8p12 3084.010.1 3084.10
808 57447.051.1- NDRG2 NM_016317 14q11.2 57447.051.1 57447.51
T_at
809 80034.003.4- FAM130A2 NM_024969 2q24.3 80034.003.4 80034.3
T_at
810 2568.005.1-D_at GABRP NM_014211 5q33-q34 2568.005.1 2568.5
811 8404.032.1-F_at SPARCL1 NM_004684 4q22.1 8404.032.1 8404.32
812 2115.003.1-E_at ETV1 NM_004956 7p21.3 2115.003.1 2115.3
813 57447.035.1- NDRG2 NM_016318 14q11.2 57447.035.1 57447.35
T_at
814 8404.009.1-T_at SPARCL1 NM_004684 4q22.1 8404.009.1 8404.9
815 8404.028.3-B_at SPARCL1 NM_004684 4q22.1 8404.028.3 8404.28
816 6289.003.1-B_at SAA2 NM_030754 11p15.1-p14 6289.003.1 6289.3
817 7170.025.1-F_at TPM3 NM_001043355 1q21.2 7170.025.1 7170.25
818 8404.030.1-D_at SPARCL1 NM_004684 4q22.1 8404.030.1 8404.30
819 8404.009.1-F_at SPARCL1 NM_004684 4q22.1 8404.009.1 8404.9
820 2335.009.1-T_at FN1 NM_002035 2q34 2335.009.1 2335.9
821 22974.007.1- TPX2 NM_012112 20q11.2 22974.007.1 22974.7
F_at
822 3426.002.1-B_at CFI NM_000204 4q25 3426.002.1 3426.2
823 4638.003.1-D_at MYLK NM_005983 3q21 4638.003.1 4638.3
824 4147.011.1-T_at MATN2 NM_002381 8q22 4147.011.1 4147.11
825 6876.016.2-T_at TAGLN NM_001001527 11q23.2 6876.016.2 6876.16
826 23650.003.1- TRIM29 NM_012101 11q22-q23 23650.003.1 23650.3
F_at
827 4744.004.1-E_at NEFH NM_021076 22q12.2 4744.004.1 4744.4
828 64168.010.1- EFCBP1 NM_022351 8q21.3 64168.010.1 64168.10
F_at
829 9073.001.1-F_at CLDN8 NM_199328 21q22.11 9073.001.1 9073.1
830 5288.001.3-B_at PIK3C2G NM_004570 12p12 5288.001.3 5288.1
831 3866.005.1-D_at KRT15 NM_002275 17q21.2 3866.005.1 3866.5
832 8404.021.1-T_at SPARCL1 NM_004684 4q22.1 8404.021.1 8404.21
833 25925.011.1- ZNF521 NM_015461 18q11.2 25925.011.1 25925.11
E_at
834 23266.001.3- LPHN2 NM_012302 1p31.1 23266.001.3 23266.1
F_at
835 9232.004.1-F_at PTTG1 NM_004219 5q35.1 9232.004.1 9232.4
836 4147.005.2-F_at MATN2 NM_002382 8q22 4147.005.2 4147.5
837 2335.025.3-B_at FN1 NM_002036 2q34 2335.025.3 2335.25
838 4638.006.1-C_at MYLK NM_005984 3q21 4638.006.1 4638.6
839 147804.004.1-T LOC147804 NM_001010856 19q13.41 147804.004.1 147804.4
840 81704.013.1- DOCK8 NM_203447 9p24.3 81704.013.1 81704.13
D_at
841 54443.013.1- ANLN NM_018685 7p15-p14 54443.013.1 54443.13
B_at
842 1410.005.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.005.1 1410.5
843 25925.009.1- ZNF521 NM_015461 18q11.2 25925.009.1 25925.9
T_at
844 3204.001.1-T_at HOXA7 NM_006896 7p15-p14 3204.001.1 3204.1
845 29997.012.1- GLTSCR2 NM_015710 19q13.3 29997.012.1 29997.12
F_at
846 2.005.1-C_at A2M NM_000014 12p13.3-p12.3 2.005.1 2.5
847 140885.011.1-F SIRPA NM_001040028 20p13 140885.011.1 140885.11
848 7153.002.3-F_at TOP2A NM_001067 17q21-q22 7153.002.3 7153.2
849 1063.002.1-F_at CENPF NM_016343 1q32-q41 1063.002.1 1063.2
850 10144.021.1- FAM13A1 NM_001015046 4q22.1 10144.021.1 10144.21
F_at
851 8404.025.1-E_at SPARCL1 NM_004684 4q22.1 8404.025.1 8404.25
852 6876.020.1-B_at TAGLN NM_001001528 11q23.2 6876.020.1 6876.20
853 7170.006.1-C_at TPM3 NM_001043356 1q21.2 7170.006.1 7170.6
854 10051.016.1- SMC4 NM_001002799 3q26.1 10051.016.1 10051.16
T_at
855 5288.001.2-D_at PIK3C2G NM_004570 12p12 5288.001.2 5288.1
856 7018.029.1-T_at TF NM_001063 3q22.1 7018.029.1 7018.29
857 5627.002.1-B_at PROS1 NM_000313 3q11.2 5627.002.1 5627.2
858 57447.037.1- NDRG2 NM_016319 14q11.2 57447.037.1 57447.37
T_at
859 4147.005.2-D_at MATN2 NM_002383 8q22 4147.005.2 4147.5
860 8404.023.1-T_at SPARCL1 NM_004684 4q22.1 8404.023.1 8404.23
861 3872.006.1-D_at KRT17 NM_000422 17q12-q21 3872.006.1 3872.6
862 399687.001.1-C MYO18A NM_078471 17q11.2 399687.001.1 399687.1
863 3815.002.4-D_at KIT NM_000237 4q11-q12 3815.002.4 3815.2
864 59.034.2-B_at ACTA2 NM_001613 10q23.3 59.034.2 59.34
865 8404.035.1-T_at SPARCL1 NM_004684 4q22.1 8404.035.1 8404.35
866 8404.030.1-T_at SPARCL1 NM_004684 4q22.1 8404.030.1 8404.30
867 5997.002.2- TESC NM_017899 12q24.22 54997.002.2 54997.2
T_at
868 57561.001.1- ARRDC3 NM_020801 5q14.3 57561.001.1 57561.1
F_at
869 8404.031.1-T_at SPARCL1 NM_004684 4q22.1 8404.031.1 8404.31
870 2.025.1-E_at A2M NM_000014 12p13.3-p12.3 2.025.1 2.25
871 699.002.1-F_at BUB1 NM_004336 2q14 699.002.1 699.2
872 57447.041.1- NDRG2 NM_016320 14q11.2 57447.041.1 57447.41
F_at
873 9055.013.1-D_at PRC1 NM_003981 15q26.1 9055.013.1 9055.13
874 8404.008.1-D_at SPARCL1 NM_004684 4q22.1 8404.008.1 8404.8
875 7018.028.1-T_at TF NM_001063 3q22.1 7018.028.1 7018.28
876 2568.005.1-T_at GABRP NM_014211 5q33-q34 2568.005.1 2568.5
877 10051.005.3- SMC4 NM_001002800 3q26.1 10051.005.3 10051.5
T_at
878 2568.002.2-T_at GABRP NM_014211 5q33-q34 2568.002.2 2568.2
879 4147.004.1-F_at MATN2 NM_002384 8q22 4147.004.1 4147.4
880 2938.001.1-T_at GSTA1 NM_145740 6p12.1 2938.001.1 2938.1
881 1308.007.1-E_at COL17A1 NM_000506 10q24.3 1308.007.1 1308.7
882 2982.012.1-T_at GUCY1A3 NM_000856 4q31.3-q33| 2982.012.1 2982.12
4q31.1-q31.2
883 8404.028.1-D_at SPARCL1 NM_004684 4q22.1 8404.028.1 8404.28
884 7373.001.2-B_at COL14A1 NM_021110 8q23 7373.001.2 7373.1
885 2893.002.2-B_at GRIA4 NM_000829 11q22 2893.002.2 2893.2
886 116369.006.4-C SLC26A8 NM_052961 6p21 116369.006.4 116369.6
887 6304.007.1-T_at SATB1 NM_002971 3p23 6304.007.1 6304.7
888 2335.035.1-T_at FN1 NM_002037 2q34 2335.035.1 2335.35
889 4751.002.1-T_at NEK2 NM_002497 1q32.2-q41 4751.002.1 4751.2
890 64151.001.2- NCAPG NM_022346 4p15.33 64151.001.2 64151.1
T_at
891 29089.003.1- UBE2T NM_014176 1q32.1 29089.003.1 29089.3
T_at
892 59.031.1-B_at ACTA2 NM_001613 10q23.3 59.031.1 59.31
893 7018.025.1-T_at TF NM_001063 3q22.1 7018.025.1 7018.25
894 3860.008.1-T_at KRT13 NM_002276 17q12-q21.2 3860.008.1 3860.8
895 5858.003.3-F_at PZP NM_002864 12p13-p12.2 5858.003.3 5858.3
896 8404.009.1-C_at SPARCL1 NM_004684 4q22.1 8404.009.1 8404.9
897 7169.022.1-T_at TPM2 NM_003293 9p13.2-p13.1 7169.022.1 7169.22
898 25925.006.1- ZNF521 NM_015461 18q11.2 25925.006.1 25925.6
T_at
899 59.049.1-F_at ACTA2 NM_001613 10q23.3 59.049.1 59.49
900 5284.003.1-T_at PIGR NM_002644 1q31-q41 5284.003.1 5284.3
901 2982.002.1-F_at GUCY1A3 NM_000856 4q31.3-q33| 2982.002.1 2982.2
4q31.1-q31.2
902 2568.002.1-T_at GABRP NM_014211 5q33-q34 2568.002.1 2568.2
903 301.004.1-B_at ANXA1 NM_000700 9q12-q21.2| 301.004.1 301.4
9q12-q21.2
904 25925.011.1- ZNF521 NM_015461 18q11.2 25925.011.1 25925.11
F_at
905 59.004.1-F_at ACTA2 NM_001613 10q23.3 59.004.1 59.4
906 6289.002.1-B_at SAA2 NM_030754 11p15.1-p14 6289.002.1 6289.2
907 244.003.1-C_at ANXA8L2 NM_001630 10q11.22 244.003.1 244.3
908 11065.008.1- UBE2C NM_007020 20q13.12 11065.008.1 11065.8
C_at
909 7091.006.1-T_at TLE4 NM_007005 9q21.31 7091.006.1 7091.6
910 79608.009.1- RIC3 NM_024557 11p15.4 79608.009.1 79608.9
F_at
911 9413.002.1-T_at C9orf61 NM_004816 9q13-q21 9413.002.1 9413.2
912 7431.064.1-C_at VIM NM_003380 10p13 7431.064.1 7431.64
913 8404.029.1-E_at SPARCL1 NM_004684 4q22.1 8404.029.1 8404.29
914 6876.020.1-T_at TAGLN NM_001001529 11q23.2 6876.020.1 6876.20
915 301.005.1-T_at ANXA1 NM_000700 9q12-q21.2| 301.005.1 301.5
9q12-q21.2
916 9055.014.1-T_at PRC1 NM_003982 15q26.1 9055.014.1 9055.14
917 4281.023.1-T_at MID1 NM_000389 Xp22 4281.023.1 4281.23
918 3868.005.1-D_at KRT16 NM_005557 17q12-q21 3868.005.1 3868.5
919 1062.001.6-B_at CENPE NM_001813 4q24-q25 1062.001.6 1062.1
920 5858.005.1-T_at PZP NM_002864 12p13-p12.2 5858.005.1 5858.5
921 51201.007.1- ZDHHC2 NM_016353 8p21.3-p22 51201.007.1 51201.7
F_at
922 4240.001.1-B_at MFGE8 NM_005928 15q25 4240.001.1 4240.1
923 8404.029.1-T_at SPARCL1 NM_004684 4q22.1 8404.029.1 8404.29
924 9413.001.1-T_at C9orf61 NM_004816 9q13-q21 9413.001.1 9413.1
925 9768.005.1-T_at KIAA0101 NM_001029993 15q22.31 9768.005.1 9768.5
926 11197.001.1- WIF1 NM_007191 12q14.3 11197.001.1 11197.1
T_at
927 6285.002.1-T_at S100B NM_006272 21q22.3 6285.002.1 6285.2
928 2335.006.2-F_at FN1 NM_002038 2q34 2335.006.2 2335.6
929 7169.001.1-C_at TPM2 NM_003294 9p13.2-p13.1 7169.001.1 7169.1
930 9493.004.1-T_at KIF23 NM_004856 15q23 9493.004.1 9493.4
931 4601.014.1-T_at MXI1 NM_001008541 10q24-q25 4601.014.1 4601.14
932 51203.002.2- NUSAP1 NM_016361 15q15.1 51203.002.2 51203.2
F_at
933 7018.022.1-F_at TF NM_001063 3q22.1 7018.022.1 7018.22
934 4288.009.1-F_at MKI67 NM_002417 10q25-qter 4288.009.1 4288.9
935 8321.004.1-D_at FZD1 NM_003505 7q21 8321.004.1 8321.4
936 8564.004.1-E_at KMO NM_003679 1q42-q44 8564.004.1 8564.4
937 7169.022.1-C_at TPM2 NM_003295 9p13.2-p13.1 7169.022.1 7169.22
938 29127.013.1- RACGAP1 NM_013277 12q13.13 29127.013.1 29127.13
T_at
939 2.018.1-B_at A2M NM_000014 12p13.3-p12.3 2.018.1 2.18
940 2.005.1-D_at A2M NM_000014 12p13.3-p12.3 2.005.1 2.5
941 1058.004.2-T_at CENPA NM_001042426 2p24-p21 1058.004.2 1058.4
942 2232.014.1-C_at FDXR NM_004110 17q24-q25 2232.014.1 2232.14
943 23650.005.1- TRIM29 NM_012101 11q22-q23 23650.005.1 23650.5
E_at
944 5621.002.2-T_at PRNP NM_000311 20p13 5621.002.2 5621.2
945 51201.005.1- ZDHHC2 NM_016353 8p21.3-p22 51201.005.1 51201.5
B_at
946 667.022.1-F_at DST NM_001727 6p12.1 667.022.1 667.22
947 54443.012.1- ANLN NM_018685 7p15-p14 54443.012.1 54443.12
C_at
948 25802.003.1- LMOD1 NM_012134 1q32 25802.003.1 25802.3
C_at
949 3479.003.1-T_at IGF1 NM_000618 12q22-q23 3479.003.1 3479.3
950 94274.003.1- PPP1R14A NM_033256 19q13.1 94274.003.1 94274.3
D_at
951 84668.003.1- FAM126A NM_032581 7p15.3 84668.003.1 84668.3
T_at
952 22974.008.1- TPX2 NM_012112 20q11.2 22974.008.1 22974.8
E_at
953 55656.007.3- INTS8 NM_017864 8q22.1 55656.007.3 55656.7
B_at
954 29127.002.1- RACGAP1 NM_013277 12q13.13 29127.002.1 29127.2
T_at
955 4281.012.2-T_at MID1 NM_000390 Xp22 4281.012.2 4281.12
956 2335.013.1-B_at FN1 NM_002039 2q34 2335.013.1 2335.13
957 79627.003.1- OGFRL1 NM_024576 6q13 79627.003.1 79627.3
B_at
958 2982.014.1-T_at GUCY1A3 NM_000856 4q31.3-q33| 2982.014.1 2982.14
4q31.1-q31.2
959 2335.053.1-T_at FN1 NM_002040 2q34 2335.053.1 2335.53
960 667.001.1-F_at DST NM_001728 6p12.1 667.001.1 667.1
961 8404.030.1-B_at SPARCL1 NM_004684 4q22.1 8404.030.1 8404.30
962 2335.025.1-C_at FN1 NM_002041 2q34 2335.025.1 2335.25
963 140885.010.3-D SIRPA NM_001040029 20p13 140885.010.3 140885.10
964 55366.001.2- LGR4 NM_018490 11p14-p13 55366.001.2 55366.1
F_at
965 7169.015.1-D_at TPM2 NM_003296 9p13.2-p13.1 7169.015.1 7169.15
966 57447.002.1- NDRG2 NM_016321 14q11.2 57447.002.1 57447.2
B_at
967 22974.008.1- TPX2 NM_012112 20q11.2 22974.008.1 22974.8
T_at
968 6876.011.1-C_at TAGLN NM_001001530 11q23.2 6876.011.1 6876.11
969 4281.008.2-D_at MID1 NM_000391 Xp22 4281.008.2 4281.8
970 59.008.1-T_at ACTA2 NM_001613 10q23.3 59.008.1 59.8
971 23266.008.1- LPHN2 NM_012302 1p31.1 23266.008.1 23266.8
F_at
972 2568.003.2-T_at GABRP NM_014211 5q33-q34 2568.003.2 2568.3
973 5311.003.1-T_at PKD2 NM_000297 4q21-q23 5311.003.1 5311.3
974 6304.011.1-T_at SATB1 NM_002971 3p23 6304.011.1 6304.11
975 3861.008.1-B_at KRT14 NM_000526 17q12-q21 3861.008.1 3861.8
976 7018.013.1-B_at TF NM_001063 3q22.1 7018.013.1 7018.13
977 8404.005.1-F_at SPARCL1 NM_004684 4q22.1 8404.005.1 8404.5
978 7170.027.1-C_at TPM3 NM_001043357 1q21.2 7170.027.1 7170.27
979 8404.023.1-C_at SPARCL1 NM_004684 4q22.1 8404.023.1 8404.23
980 7373.007.1-C_at COL14A1 NM_021110 8q23 7373.007.1 7373.7
981 1410.009.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.009.1 1410.9
982 79745.004.3- CLIP4 NM_024692 2p23.2 79745.004.3 79745.4
D_at
983 24137.004.1- KIF4A NM_012310 Xq13.1 24137.004.1 24137.4
T_at
984 6241.013.1-B_at RRM2 NM_001034 2p25-p24 6241.013.1 6241.13
985 1410.001.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.001.1 1410.1
986 4781.015.2-B_at NFIB NM_005596 9p24.1 4781.015.2 4781.15
987 72.002.1-T_at ACTG2 NM_001615 2p13.1 72.002.1 72.2
988 4833.004.1-D_at NME4 NM_005009 16p13.3 4833.004.1 4833.4
989 57447.024.1- NDRG2 NM_016322 14q11.2 57447.024.1 57447.24
D_at
990 2982.013.2-T_at GUCY1A3 NM_000856 4q31.3-q33| 2982.013.2 2982.13
4q31.1-q31.2
991 79971.012.1- GPR177 NM_001002292 1p31.3 79971.012.1 79971.12
T_at
992 8404.028.3-C_at SPARCL1 NM_004684 4q22.1 8404.028.3 8404.28
993 4638.011.1-E_at MYLK NM_005985 3q21 4638.011.1 4638.11
994 7169.004.1-C_at TPM2 NM_003297 9p13.2-p13.1 7169.004.1 7169.4
995 4288.004.1-F_at MKI67 NM_002417 10q25-qter 4288.004.1 4288.4
996 59.012.2-C_at ACTA2 NM_001613 10q23.3 59.012.2 59.12
997 301.008.1-B_at ANXA1 NM_000700 9q12-q21.2| 301.008.1 301.8
9q12-q21.2
998 4281.012.1-T_at MID1 NM_000381; Xp22 4281.012.1 4281.12
999 2335.016.1-F_at FN1 NM_002042 2q34 2335.016.1 2335.16
1000 259266.003.1-C ASPM NM_018136 1q31 259266.003.1 259266.3
1001 9055.020.1-T_at PRC1 NM_003983 15q26.1 9055.020.1 9055.20
1002 7091.016.1-T_at TLE4 NM_007005 9q21.31 7091.016.1 7091.16
1003 59.023.1-T_at ACTA2 NM_001613 10q23.3 59.023.1 59.23
1004 57162.010.1- PELI1 NM_020651 2p13.3 57162.010.1 57162.10
B_at
1005 4781.002.2-D_at NFIB NM_005596 9p24.1 4781.002.2 4781.2
1006 6122.037.1-T_at RPL3 NM_000967 22q13 6122.037.1 6122.37
1007 4240.015.1-B_at MFGE8 NM_005928 15q25 4240.015.1 4240.15
1008 59.034.1-T_at ACTA2 NM_001613 10q23.3 59.034.1 59.34
1009 8404.004.2-D_at SPARCL1 NM_004684 4q22.1 8404.004.2 8404.4
1010 9413.001.2-T_at C9orf61 NM_004816 9q13-q21 9413.001.2 9413.1
1011 2.005.1-F_at A2M NM_000014 12p13.3-p12.3 2.005.1 2.5
1012 6304.002.1-T_at SATB1 NM_002971 3p23 6304.002.1 6304.2
1013 3852.005.1-C_at KRT5 NM_000424 12q12-q13 3852.005.1 3852.5
1014 7170.027.1-B_at TPM3 NM_001043358 1q21.2 7170.027.1 7170.27
1015 301.013.1-T_at ANXA1 NM_000700 9q12-q21.2| 301.013.1 301.13
9q12-q21.2
1016 6304.012.1-F_at SATB1 NM_002971 3p23 6304.012.1 6304.12
1017 57447.051.2- NDRG2 NM_016323 14q11.2 57447.051.2 57447.51
T_at
1018 11065.005.1- UBE2C NM_007021 20q13.12 11065.005.1 11065.5
C_at
1019 6422.002.1-F_at SFRP1 NM_003012 8p12-p11.1 6422.002.1 6422.2
1020 6241.013.1-F_at RRM2 NM_001034 2p25-p24 6241.013.1 6241.13
1021 2335.032.1-T_at FN1 NM_002043 2q34 2335.032.1 2335.32
1022 11065.005.2- UBE2C NM_007022 20q13.12 11065.005.2 11065.5
T_at
1023 2335.028.1-D_at FN1 NM_002044 2q34 2335.028.1 2335.28
1024 29997.016.1- GLTSCR2 NM_015710 19q13.3 29997.016.1 29997.16
F_at
1025 7018.014.1-T_at TF NM_001063 3q22.1 7018.014.1 7018.14
1026 1410.011.1-E_at CRYAB NM_001885 11q22.3-q23.1 1410.011.1 1410.11
1027 7170.040.1-E_at TPM3 NM_001043359 1q21.2 7170.040.1 7170.40
1028 6289.002.2-F_at SAA2 NM_030754 11p15.1-p14 6289.002.2 6289.2
1029 7373.003.4-C_at COL14A1 NM_021110 8q23 7373.003.4 7373.3
1030 7170.041.1-E_at TPM3 NM_001043360 1q21.2 7170.041.1 7170.41
1031 128553.003.1-B TSHZ2 NM_173485 20q13.2 128553.003.1 128553.3
1032 4094.002.1-D_at MAF NM_001031805 16q22-q23 4094.002.1 4094.2
1033 7113.011.1-T_at TMPRSS2 NM_005656 21q22.3 7113.011.1 7113.11
1034 7170.002.1-C_at TPM3 NM_001043361 1q21.2 7170.002.1 7170.2
1035 8404.017.2-T_at SPARCL1 NM_004684 4q22.1 8404.017.2 8404.17
1036 59.029.1-T_at ACTA2 NM_001613 10q23.3 59.029.1 59.29
1037 29089.001.1- UBE2T NM_014176 1q32.1 29089.001.1 29089.1
T_at
1038 358.012.1-T_at AQP1 NM_198098 7p14 358.012.1 358.12
1039 9134.001.1-B_at CCNE2 NM_057735 8q22.1 9134.001.1 9134.1
1040 2335.013.1-C_at FN1 NM_002045 2q34 2335.013.1 2335.13
1041 1410.010.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.010.1 1410.10
1042 2327.003.4-F_at FMO2 NM_001460 1q23-q25 2327.003.4 2327.3
1043 59.042.1-T_at ACTA2 NM_001613 10q23.3 59.042.1 59.42
1044 6304.007.2-T_at SATB1 NM_002971 3p23 6304.007.2 6304.7
1045 8404.031.1-B_at SPARCL1 NM_004684 4q22.1 8404.031.1 8404.31
1046 6289.001.1-F_at SAA2 NM_030754 11p15.1-p14 6289.001.1 6289.1
1047 1410.006.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.006.1 1410.6
1048 80034.004.1- FAM130A2 NM_024969 2q24.3 80034.004.1 80034.4
T_at
1049 1410.008.1-T_at CRYAB NM_001885 11q22.3-q23.1 1410.008.1 1410.8
1050 57447.051.2- NDRG2 NM_016324 14q11.2 57447.051.2 57447.51
D_at
1051 7170.016.3-B_at TPM3 NM_001043362 1q21.2 7170.016.3 7170.16
1052 4240.001.1-C_at MFGE8 NM_005928 15q25 4240.001.1 4240.1
1053 6288.001.1-T_at SAA1 NM_000331 11p15.1 6288.001.1 6288.1
1054 7018.014.1-C_at TF NM_001063 3q22.1 7018.014.1 7018.14
1055 8404.020.1-T_at SPARCL1 NM_004684 4q22.1 8404.020.1 8404.20
1056 6289.001.2-F_at SAA2 NM_030754 11p15.1-p14 6289.001.2 6289.1
1057 6876.011.1-F_at TAGLN NM_001001531 11q23.2 6876.011.1 6876.11
1058 8404.031.1-C_at SPARCL1 NM_004684 4q22.1 8404.031.1 8404.31
1059 57447.010.1- NDRG2 NM_016325 14q11.2 57447.010.1 57447.10
T_at
1060 1410.007.2-C_at CRYAB NM_001885 11q22.3-q23.1 1410.007.2 1410.7
1061 59.012.2-B_at ACTA2 NM_001613 10q23.3 59.012.2 59.12
1062 3459.005.1-T_at IFNGR1 NM_000416 6q23-q24 3459.005.1 3459.5
1063 301.013.1-C_at ANXA1 NM_000700 9q12-q21.2| 301.013.1 301.13
9q12-q21.2
1064 83539.001.1- CHST9 NM_031422 18q11.2 83539.001.1 83539.1
D_at
1065 6288.004.1-F_at SAA1 NM_000332 11p15.1 6288.004.1 6288.4
1066 4781.016.1-E_at NFIB NM_005596 9p24.1 4781.016.1 4781.16
1067 29997.012.1- GLTSCR2 NM_015710 19q13.3 29997.012.1 29997.12
E_at
1068 57447.021.1- NDRG2 NM_016326 14q11.2 57447.021.1 57447.21
T_at
1069 3426.002.1-C_at CFI NM_000204 4q25 3426.002.1 3426.2
1070 53829.001.2- P2RY13 NM_023914 3q24 53829.001.2 53829.1
T_at
1071 2115.001.2-B_at ETV1 NM_004956 7p21.3 2115.001.2 2115.1
1072 10051.008.1- SMC4 NM_001002801 3q26.1 10051.008.1 10051.8
T_at
1073 1033.002.1-T_at CDKN3 NM_005192 14q22 1033.002.1 1033.2
1074 2335.005.1-D_at FN1 NM_002046 2q34 2335.005.1 2335.5
1075 7113.009.1-T_at TMPRSS2 NM_005656 21q22.3 7113.009.1 7113.9
1076 3866.002.1-B_at KRT15 NM_002275 17q21.2 3866.002.1 3866.2
1077 140885.014.1-D SIRPA NM_001040030 20p13 140885.014.1 140885.14
1078 7168.003.1-T_at TPM1 NM_000366 15q22.1 7168.003.1 7168.3
1079 79608.001.1- RIC3 NM_024557 11p15.4 79608.001.1 79608.1
T_at
1080 79608.008.2- RIC3 NM_024557 11p15.4 79608.008.2 79608.8
F_at
1081 1410.001.1-B_at CRYAB NM_001885 11q22.3-q23.1 1410.001.1 1410.1
1082 7113.010.1-T_at TMPRSS2 NM_005656 21q22.3 7113.010.1 7113.10
1083 4781.014.2-B_at NFIB NM_005596 9p24.1 4781.014.2 4781.14
1084 2335.016.1-E_at FN1 NM_002047 2q34 2335.016.1 2335.16
1085 11065.003.1- UBE2C NM_007023 20q13.12 11065.003.1 11065.3
T_at
1086 3872.006.1-T_at KRT17 NM_000422 17q12-q21 3872.006.1 3872.6
1087 3084.005.1-F_at NRG1 NM_004517 8p12 3084.005.1 3084.5
1088 6285.003.1-T_at S100B NM_006272 21q22.3 6285.003.1 6285.3
1089 6876.016.2-F_at TAGLN NM_001001532 11q23.2 6876.016.2 6876.16
1090 8404.004.1-T_at SPARCL1 NM_004684 4q22.1 8404.004.1 8404.4
1091 54829.001.1- ASPN NM_017680 9q22 54829.001.1 54829.1
F_at
1092 8404.001.1-T_at SPARCL1 NM_004684 4q22.1 8404.001.1 8404.1
1093 9055.011.1-E_at PRC1 NM_003984 15q26.1 9055.011.1 9055.11
1094 6289.003.2-F_at SAA2 NM_030754 11p15.1-p14 6289.003.2 6289.3
1095 22974.007.1- TPX2 NM_012112 20q11.2 22974.007.1 22974.7
T_at
1096 59.023.2-T_at ACTA2 NM_001613 10q23.3 59.023.2 59.23
1097 7169.015.1-T_at TPM2 NM_003298 9p13.2-p13.1 7169.015.1 7169.15
1098 6289.002.1-F_at SAA2 NM_030754 11p15.1-p14 6289.002.1 6289.2
1099 4288.008.1-B_at MKI67 NM_002417 10q25-qter 4288.008.1 4288.8
1100 4781.007.1-B_at NFIB NM_005596 9p24.1 4781.007.1 4781.7
1101 6876.023.1-T_at TAGLN NM_001001533 11q23.2 6876.023.1 6876.23
1102 9055.017.1-F_at PRC1 NM_003985 15q26.1 9055.017.1 9055.17
1103 7170.018.2-D_at TPM3 NM_001043363 1q21.2 7170.018.2 7170.18
1104 4781.014.2-D_at NFIB NM_005596 9p24.1 4781.014.2 4781.14
1105 7170.025.1-T_at TPM3 NM_001043364 1q21.2 7170.025.1 7170.25
1106 7018.025.1-B_at TF NM_001063 3q22.1 7018.025.1 7018.25
1107 10253.003.1- SPRY2 NM_005842 13q31.1 10253.003.1 10253.3
T_at
1108 57447.039.1- NDRG2 NM_016327 14q11.2 57447.039.1 57447.39
D_at
1109 59.022.1-T_at ACTA2 NM_001613 10q23.3 59.022.1 59.22
1110 2982.015.1-F_at GUCY1A3 NM_000856 4q31.3-q33| 2982.015.1 2982.15
4q31.1-q31.2
1111 10124.004.2- ARL4A NM_001037166 7p21-p15.3 10124.004.2 10124.4
F_at
1112 6289.001.1-B_at SAA2 NM_030754 11p15.1-p14 6289.001.1 6289.1
1113 7091.005.1-F_at TLE4 NM_007005 9q21.31 7091.005.1 7091.5
1114 501.006.1-B_at ALDH7A1 NM_001182 5q31 501.006.1 501.6
1115 1410.001.1-C_at CRYAB NM_001885 11q22.3-q23.1 1410.001.1 1410.1
1116 57447.021.1- NDRG2 NM_016328 14q11.2 57447.021.1 57447.21
C_at
1117 244.012.1-B_at ANXA8L2 NM_001630 10q11.22 244.012.1 244.12
1118 7018.026.1-F_at TF NM_001063 3q22.1 7018.026.1 7018.26
1119 3872.018.1-T_at KRT17 NM_000422 17q12-q21 3872.018.1 3872.18
1120 10144.017.3- FAM13A1 NM_001015047 4q22.1 10144.017.3 10144.17
T_at
1121 11197.001.1- WIF1 NM_007191 12q14.3 11197.001.1 11197.1
F_at
1122 29127.007.1- RACGAP1 NM_013277 12q13.13 29127.007.1 29127.7
B_at
1123 10010.004.1- TANK NM_004181 2q24-q31 10010.004.1 10010.4
F_at
1124 81704.013.1- DOCK8 NM_203447 9p24.3 81704.013.1 81704.13
C_at
1125 4781.006.2-B_at NFIB NM_005596 9p24.1 4781.006.2 4781.6
1126 7373.003.1-F_at COL14A1 NM_021110 8q23 7373.003.1 7373.3
1127 8404.009.1-D_at SPARCL1 NM_004684 4q22.1 8404.009.1 8404.9
1128 23092.004.1- ARHGAP26 NM_015071 5q31 23092.004.1 23092.4
T_at
1129 2335.002.1-F_at FN1 NM_002048 2q34 2335.002.1 2335.2
1130 8404.031.1-F_at SPARCL1 NM_004684 4q22.1 8404.031.1 8404.31
1131 6304.006.2-T_at SATB1 NM_002971 3p23 6304.006.2 6304.6
1132 1410.008.1-E_at CRYAB NM_001885 11q22.3-q23.1 1410.008.1 1410.8
1133 9055.019.1-F_at PRC1 NM_003986 15q26.1 9055.019.1 9055.19
1134 1398.001.1-D_at CRK NM_000509 17p13.3 1398.001.1 1398.1
1135 57447.051.1- NDRG2 NM_016329 14q11.2 57447.051.1 57447.51
E_at
1136 339965.001.2-B FLJ25770 NM_001042784 4q21.1 339965.001.2 339965.1
1137 7113.001.1-C_at TMPRSS2 NM_005656 21q22.3 7113.001.1 7113.1
1138 4240.009.1-D_at MFGE8 NM_005928 15q25 4240.009.1 4240.9
1139 7153.002.4-B_at TOP2A NM_001067 17q21-q22 7153.002.4 7153.2
1140 7169.004.1-D_at TPM2 NM_003299 9p13.2-p13.1 7169.004.1 7169.4
1141 1410.001.1-D_at CRYAB NM_001885 11q22.3-q23.1 1410.001.1 1410.1
1142 59.015.2-B_at ACTA2 NM_001613 10q23.3 59.015.2 59.15
1143 4833.010.1-T_at NME4 NM_005009 16p13.3 4833.010.1 4833.10
1144 7169.022.1-B_at TPM2 NM_003300 9p13.2-p13.1 7169.022.1 7169.22
1145 11065.005.1- UBE2C NM_007024 20q13.12 11065.005.1 11065.5
T_at
1146 7170.018.2-T_at TPM3 NM_001043365 1q21.2 7170.018.2 7170.18
1147 79971.013.2- GPR177 NM_001002293 1p31.3 79971.013.2 79971.13
F_at
1148 152015.005.2-F ROPN1B NM_001012337 3q21.2 152015.005.2 152015.5
1149 4288.005.1-D_at MKI67 NM_002417 10q25-qter 4288.005.1 4288.5
1150 8404.002.1-T_at SPARCL1 NM_004684 4q22.1 8404.002.1 8404.2
1151 6441.004.1-E_at SFTPD NM_003019 10q22.2-q23.1 6441.004.1 6441.4
1152 6122.046.1-B_at RPL3 NM_000967 22q13 6122.046.1 6122.46
1153 115908.002.1-T CTHRC1 NM_138455 8q22.3 115908.002.1 115908.2
1154 9481.001.1-F_at SLC25A27 NM_004277 6p11.2-q12 9481.001.1 9481.1
1155 8404.008.1-T_at SPARCL1 NM_004684 4q22.1 8404.008.1 8404.8
1156 1410.007.1-D_at CRYAB NM_001885 11q22.3-q23.1 1410.007.1 1410.7
1157 8404.030.1-C_at SPARCL1 NM_004684 4q22.1 8404.030.1 8404.30
1158 57447.039.1- NDRG2 NM_016330 14q11.2 57447.039.1 57447.39
T_at
1159 4147.004.1-E_at MATN2 NM_002385 8q22 4147.004.1 4147.4
1160 2335.024.2-F_at FN1 NM_002049 2q34 2335.024.2 2335.24
1161 891.007.1-T_at CCNB1 NM_031966 5q12 891.007.1 891.7
1162 2335.002.1-T_at FN1 NM_002050 2q34 2335.002.1 2335.2
1163 8404.017.1-T_at SPARCL1 NM_004684 4q22.1 8404.017.1 8404.17
1164 57451.004.1- ODZ2 NM_001080428 5q34-q35.1 57451.004.1 57451.4
B_at
1165 8404.001.1-F_at SPARCL1 NM_004684 4q22.1 8404.001.1 8404.1
1166 8626.006.2-B_at TP63 NM_003722 3q28 8626.006.2 8626.6
1167 2335.025.1-T_at FN1 NM_002051 2q34 2335.025.1 2335.25
1168 6286.001.1-T_at S100P NM_005980 4p16 6286.001.1 6286.1
1169 10580.012.1- SORBS1 NM_001034954 10q23.3-q24.1 10580.012.1 10580.12
C_at
1170 23321.014.1- TRIM2 NM_015271 4q31.3 23321.014.1 23321.14
T_at
1171 2824.001.2-B_at GPM6B NM_001001994 Xp22.2 2824.001.2 2824.1
1172 29127.022.1- RACGAP1 NM_013277 12q13.13 29127.022.1 29127.22
T_at
1173 6289.003.1-F_at SAA2 NM_030754 11p15.1-p14 6289.003.1 6289.3
1174 7170.005.2-B_at TPM3 NM_001043366 1q21.2 7170.005.2 7170.5
1175 54443.011.1- ANLN NM_018685 7p15-p14 54443.011.1 54443.11
F_at
1176 29127.019.1- RACGAP1 NM_013277 12q13.13 29127.019.1 29127.19
T_at
1177 6288.004.1-T_at SAA1 NM_000333 11p15.1 6288.004.1 6288.4
1178 29997.008.1- GLTSCR2 NM_015710 19q13.3 29997.008.1 29997.8
C_at
1179 57447.039.1- NDRG2 NM_016331 14q11.2 57447.039.1 57447.39
B_at
1180 3872.007.1-B_at KRT17 NM_000422 17q12-q21 3872.007.1 3872.7
1181 57561.002.1- ARRDC3 NM_020801 5q14.3 57561.002.1 57561.2
T_at
1182 57451.002.3- ODZ2 NM_001080428 5q34-q35.1 57451.002.3 57451.2
B_at
1183 5213.024.1-B_at PFKM NM_000289 12q13.3 5213.024.1 5213.24
1184 2.005.1-T_at A2M NM_000014 12p13.3-p12.3 2.005.1 2.5
1185 11065.004.1- UBE2C NM_007025 20q13.12 11065.004.1 11065.4
C_at
1186 1410.006.1-C_at CRYAB NM_001885 11q22.3-q23.1 1410.006.1 1410.6
1187 6289.006.1-T_at SAA2 NM_030754 11p15.1-p14 6289.006.1 6289.6
1188 55366.001.1- LGR4 NM_018490 11p14-p13 55366.001.1 55366.1
T_at
1189 23284.007.1- LPHN3 NM_015236 4q13.1 23284.007.1 23284.7
F_at
1190 79971.009.1- GPR177 NM_001002294 1p31.3 79971.009.1 79971.9
T_at
1191 6288.004.1-E_at SAA1 NM_000334 11p15.1 6288.004.1 6288.4
1192 11065.004.1- UBE2C NM_007026 20q13.12 11065.004.1 11065.4
T_at
1193 51203.009.1- NUSAP1 NM_016362 15q15.1 51203.009.1 51203.9
T_at
1194 1410.010.1-E_at CRYAB NM_001885 11q22.3-q23.1 1410.010.1 1410.10
1195 57447.030.1- NDRG2 NM_016332 14q11.2 57447.030.1 57447.30
D_at
1196 1308.002.1-T_at COL17A1 NM_000507 10q24.3 1308.002.1 1308.2
1197 4288.007.1-C_at MKI67 NM_002417 10q25-qter 4288.007.1 4288.7
1198 244.011.1-T_at ANXA8L2 NM_001630 10q11.22 244.011.1 244.11
1199 94274.003.1- PPP1R14A NM_033256 19q13.1 94274.003.1 94274.3
B_at
1200 3178.003.1-E_at HNRNPA1 NM_002136 12q13.1 3178.003.1 3178.3
1201 7153.002.4-T_at TOP2A NM_001067 17q21-q22 7153.002.4 7153.2
1202 9055.012.1-D_at PRC1 NM_003987 15q26.1 9055.012.1 9055.12
1203 9232.001.1-E_at PTTG1 NM_004219 5q35.1 9232.001.1 9232.1
1204 79068.011.2- FTO NM_001080432 16q12.2 79068.011.2 79068.11
B_at
1205 120.005.2-F_at ADD3 NM_001122 10q24.2-q24.3 120.005.2 120.5
1206 7534.001.1-C_at YWHAZ NM_003406 8q23.1 7534.001.1 7534.1
1207 120.005.2-T_at ADD3 NM_001123 10q24.2-q24.3 120.005.2 120.5
1208 7373.003.3-C_at COL14A1 NM_021110 8q23 7373.003.3 7373.3
1209 57447.004.2- NDRG2 NM_016333 14q11.2 57447.004.2 57447.4
D_at
1210 2568.005.1-F_at GABRP NM_014211 5q33-q34 2568.005.1 2568.5
1211 1308.001.1-E_at COL17A1 NM_000508 10q24.3 1308.001.1 1308.1
1212 6876.020.1-F_at TAGLN NM_001001534 11q23.2 6876.020.1 6876.20
1213 79971.014.1- GPR177 NM_001002295 1p31.3 79971.014.1 79971.14
D_at
1214 5621.008.1-D_at PRNP NM_000312 20p13 5621.008.1 5621.8
1215 55732.003.2- C1orf112 NM_018186 1q24.2 55732.003.2 55732.3
T_at
1216 221120.006.1-D ALKBH3 NM_139178 11p11.2 221120.006.1 221120.6
1217 23266.008.1- LPHN2 NM_012302 1p31.1 23266.008.1 23266.8
T_at
1218 2335.045.1-F_at FN1 NM_002052 2q34 2335.045.1 2335.45
1219 7170.007.1-F_at TPM3 NM_001043367 1q21.2 7170.007.1 7170.7
1220 10461.002.1- MERTK NM_006343 2q14.1 10461.002.1 10461.2
B_at
1221 59.031.2-F_at ACTA2 NM_001613 10q23.3 59.031.2 59.31
1222 9055.010.1-T_at PRC1 NM_003988 15q26.1 9055.010.1 9055.10
1223 58499.005.2- ZNF462 NM_021224 9q31.2 58499.005.2 58499.5
F_at
1224 54443.006.2- ANLN NM_018685 7p15-p14 54443.006.2 54443.6
F_at
1225 59.016.1-B_at ACTA2 NM_001613 10q23.3 59.016.1 59.16
1226 4288.004.1-C_at MKI67 NM_002417 10q25-qter 4288.004.1 4288.4
1227 7170.014.1-C_at TPM3 NM_001043368 1q21.2 7170.014.1 7170.14
1228 7170.007.1-D_at TPM3 NM_001043369 1q21.2 7170.007.1 7170.7
TABLE 5
Table 5. Average profiles of the preferred 1,228 signature probe
set on the 24 benign and 70 malignant tissues of the training set.
NO Probeset_Id benign profile malignant profile
1 1756.022.2-C_at 7.77577583 3.59039694
2 1756.029.1-D_at 7.04295703 3.513387741
3 1756.026.1-C_at 6.95161337 3.464276589
4 1756.022.4-T_at 6.48188081 3.420868252
5 1756.011.1-B_at 6.86417826 3.496864254
6 1308.008.1-C_at 7.57956334 3.687873002
7 1756.022.3-F_at 6.51097796 3.58405119
8 3861.020.1-D_at 6.22316661 3.499798722
9 1756.011.1-F_at 6.46286419 3.439670248
10 4629.007.1-F_at 7.83187958 4.047826786
11 1756.022.4-B_at 5.66870747 3.376207029
12 1756.024.1-F_at 5.6343038 3.538881886
13 3861.019.1-T_at 6.68378293 3.662794206
14 1756.026.1-T_at 5.75006153 3.403683849
15 1756.022.1-B_at 5.5659674 3.347255374
16 3861.001.1-T_at 8.03618493 4.233009236
17 1308.008.1-T_at 7.11931893 3.582324909
18 4629.020.1-C_at 5.83439993 3.404790946
19 1756.027.1-T_at 5.61961823 3.38354471
20 3861.013.1-T_at 6.54371337 3.606451019
21 4629.020.1-F_at 8.29507715 4.572815098
22 3861.001.1-B_at 6.22211499 3.452593672
23 1756.022.4-F_at 5.86145739 3.406465282
24 1756.026.1-F_at 5.60288028 3.360497686
25 1756.022.2-T_at 5.58253289 3.54186397
26 1756.022.2-F_at 5.61962239 3.502994928
27 3861.022.1-B_at 7.02845041 3.87855387
28 3868.004.1-D_at 7.74158414 4.319798082
29 4629.015.1-C_at 7.25657837 3.723809766
30 6422.002.1-E_at 8.94850792 4.159424522
31 3861.001.1-D_at 6.09123229 3.432322015
32 1756.022.1-F_at 5.69246198 3.544494185
33 1308.003.1-T_at 7.94010542 4.370493824
34 3868.005.1-B_at 8.74334588 5.189519553
35 1308.007.1-F_at 6.53872712 4.045429995
36 1308.009.1-F_at 6.89532626 4.071167435
37 3861.007.1-E_at 6.32900696 3.492862508
38 4629.016.1-D_at 6.54432919 3.640775643
39 3084.007.1-F_at 5.24077491 3.36157297
40 3861.007.1-F_at 8.80010947 5.27987695
41 26289.003.1-E_at 5.86287574 3.533159027
42 1756.028.1-T_at 5.51782565 3.40968711
43 4629.021.1-E_at 5.66627575 3.423025757
44 4629.020.1-D_at 6.44086194 3.546901356
45 5764.001.1-F_at 8.69561376 4.488059326
46 3815.002.3-F_at 7.51289238 3.849064631
47 3852.020.1-T_at 6.42797621 4.732898695
48 4629.007.1-E_at 6.02756027 3.473012819
49 128553.003.1-F 5.53321089 3.635562107
50 26289.003.1-F_at 7.91558754 4.209493355
51 3815.002.2-F_at 7.57464628 4.354458317
52 1756.029.1-B_at 5.14699565 3.349809112
53 4629.005.1-E_at 7.84091036 4.284271836
54 4629.010.1-B_at 6.24893878 4.055036115
55 6422.001.1-T_at 7.16633034 3.787746012
56 5764.001.1-E_at 7.41150914 3.725088834
57 3861.008.1-F_at 7.02710456 4.066582177
58 1756.030.2-T_at 4.94195769 3.327396148
59 3084.009.1-B_at 5.68938525 3.45247142
60 26289.002.1-T_at 7.40948494 4.099092499
61 1756.022.5-B_at 5.43279988 3.481330797
62 4629.007.1-D_at 6.12853852 3.536108886
63 23336.001.1-C_at 6.64495461 3.668475185
64 1308.003.1-D_at 5.60928126 3.379520915
65 1756.022.3-T_at 5.52680369 3.62832307
66 3861.020.1-T_at 7.58427914 5.411375294
67 3861.022.1-C_at 5.51190841 3.385538085
68 3852.012.2-B_at 8.68398341 6.89513729
69 26289.012.1-E_at 7.90570335 4.172489159
70 23336.003.1-T_at 7.08201667 4.814503945
71 26289.007.1-B_at 7.72470925 4.152306769
72 84417.001.1-T_at 5.09011844 3.400475459
73 3861.018.1-D_at 5.42966542 3.382067375
74 3852.004.1-B_at 6.45366587 4.048382242
75 90865.006.1-B_at 6.73968166 3.990889311
76 4629.021.1-F_at 7.91177883 5.2531203
77 3861.018.1-T_at 6.93768003 4.389579877
78 1756.022.1-T_at 5.49427991 3.678236167
79 1264.003.1-B_at 6.59427618 3.644806029
80 26289.010.1-E_at 7.89895995 4.173752776
81 3861.001.1-F_at 8.22227254 5.365451942
82 1908.002.1-T_at 5.89142159 3.76026543
83 4629.007.1-C_at 5.95159281 3.449026103
84 1756.022.5-T_at 7.41985492 5.430396438
85 3815.002.4-B_at 6.82005827 3.837481838
86 1756.022.2-B_at 5.20019167 3.394669911
87 1756.027.1-B_at 4.8537932 3.389107204
88 3852.008.2-T_at 6.48445207 3.985807972
89 6422.001.1-E_at 7.27907161 3.874506745
90 3861.022.1-F_at 6.81336417 5.057032572
91 4915.011.1-D_at 5.90431076 3.64199141
92 5288.001.1-F_at 5.44594693 3.485884155
93 3861.007.1-T_at 7.95368914 5.49032736
94 3852.006.1-C_at 6.13678531 3.559093796
95 9413.003.1-T_at 5.34538697 3.552156816
96 3861.020.1-C_at 5.55692471 3.41004352
97 1308.008.1-D_at 5.59542139 3.406938539
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1101 6876.023.1-T_at 5.30318153 3.837265148
1102 9055.017.1-F_at 4.93875917 6.675610123
1103 7170.018.2-D_at 8.97464252 9.731315695
1104 4781.014.2-D_at 6.62173963 4.59382551
1105 7170.025.1-T_at 10.1528395 10.84778358
1106 7018.025.1-B_at 5.85576515 3.729848132
1107 10253.003.1-T_at 5.21328569 3.796731651
1108 57447.039.1-D_at 6.20353459 4.650979725
1109 59.022.1-T_at 5.01607936 3.66486644
1110 2982.015.1-F_at 6.52910873 4.398315488
1111 10124.004.2-F_at 5.65171957 4.395524581
1112 6289.001.1-B_at 8.84060005 6.026432745
1113 7091.005.1-F_at 6.22924785 4.644117845
1114 501.006.1-B_at 5.49535249 3.832258169
1115 1410.001.1-C_at 8.37978611 5.283357954
1116 57447.021.1-C_at 6.64989625 4.516711936
1117 244.012.1-B_at 4.57455863 3.452384416
1118 7018.026.1-F_at 7.02591455 4.884695118
1119 3872.018.1-T_at 5.9287371 4.536856978
1120 10144.017.3-T_at 5.24556385 3.811639459
1121 11197.001.1-F_at 5.1313114 3.685307479
1122 29127.007.1-B_at 3.92146605 5.671967353
1123 10010.004.1-F_at 6.85011832 5.471009514
1124 81704.013.1-C_at 7.00929626 5.228254202
1125 4781.006.2-B_at 7.95071123 5.849829769
1126 7373.003.1-F_at 4.96962295 3.466223281
1127 8404.009.1-D_at 7.25304506 5.54375843
1128 23092.004.1-T_at 5.63034915 4.135821153
1129 2335.002.1-F_at 4.95716635 7.470035933
1130 8404.031.1-F_at 8.49473661 6.266230481
1131 6304.006.2-T_at 6.19437915 4.664814203
1132 1410.008.1-E_at 8.35323964 5.23093246
1133 9055.019.1-F_at 5.08438207 6.749313988
1134 1398.001.1-D_at 6.62952 5.474846977
1135 57447.051.1-E_at 7.64975415 6.754949154
1136 339965.001.2-B 6.09281787 4.427445717
1137 7113.001.1-C_at 6.49441996 4.364555738
1138 4240.009.1-D_at 6.92405991 4.992040248
1139 7153.002.4-B_at 3.9192437 5.943978275
1140 7169.004.1-D_at 10.5243791 9.455104283
1141 1410.001.1-D_at 10.4537888 7.669238725
1142 59.015.2-B_at 4.65235051 3.439217599
1143 4833.010.1-T_at 7.67064462 8.499214874
1144 7169.022.1-B_at 8.88810535 7.392553599
1145 11065.005.1-T_at 4.40063594 6.264196367
1146 7170.018.2-T_at 9.1005517 9.929531193
1147 79971.013.2-F_at 7.81954831 5.197831093
1148 152015.005.2-F 5.50228015 3.631181096
1149 4288.005.1-D_at 3.58855622 5.41357555
1150 8404.002.1-T_at 7.82572709 5.654573319
1151 6441.004.1-E_at 7.06431123 5.1604289
1152 6122.046.1-B_at 10.4919703 9.7185156
1153 115908.002.1-T 3.8854167 5.716319219
1154 9481.001.1-F_at 4.56745873 3.48672793
1155 8404.008.1-T_at 7.67594705 5.231619593
1156 1410.007.1-D_at 8.38485465 5.254780902
1157 8404.030.1-C_at 8.36615125 6.003710685
1158 57447.039.1-T_at 6.16284998 4.598519131
1159 4147.004.1-E_at 6.5996408 4.306043014
1160 2335.024.2-F_at 4.14778676 6.724104869
1161 891.007.1-T_at 4.37836908 6.277454073
1162 2335.002.1-T_at 3.69677239 5.842235509
1163 8404.017.1-T_at 7.62129329 5.344108953
1164 57451.004.1-B_at 4.98513349 3.645263861
1165 8404.001.1-F_at 7.80115205 5.644594488
1166 8626.006.2-B_at 4.99013916 3.634011318
1167 2335.025.1-T_at 5.20342277 7.312790967
1168 6286.001.1-T_at 4.37066146 7.627611404
1169 10580.012.1-C_at 5.72236701 4.332788093
1170 23321.014.1-T_at 4.77278608 3.653834143
1171 2824.001.2-B_at 6.86512458 5.132614728
1172 29127.022.1-T_at 4.01626993 5.699644246
1173 6289.003.1-F_at 8.04884622 5.558117392
1174 7170.005.2-B_at 7.21902208 8.187290968
1175 54443.011.1-F_at 3.90847075 5.715840566
1176 29127.019.1-T_at 4.45515346 6.238930793
1177 6288.004.1-T_at 8.9163962 6.203405757
1178 29997.008.1-C_at 8.54806753 7.280192975
1179 57447.039.1-B_at 8.64953038 6.241324868
1180 3872.007.1-B_at 5.78319757 3.824950968
1181 57561.002.1-T_at 7.04642246 5.352091902
1182 57451.002.3-B_at 4.71308984 3.460721722
1183 5213.024.1-B_at 5.69666791 4.585191172
1184 2.005.1-T_at 9.54067496 7.938923018
1185 11065.004.1-C_at 3.58696224 5.482200678
1186 1410.006.1-C_at 8.38947588 5.204282844
1187 6289.006.1-T_at 6.36227497 4.331717996
1188 55366.001.1-T_at 5.81899126 4.357905799
1189 23284.007.1-F_at 5.22440061 3.837622352
1190 79971.009.1-T_at 7.81567707 5.261440799
1191 6288.004.1-E_at 6.55709998 4.810646704
1192 11065.004.1-T_at 4.59241158 6.359329521
1193 51203.009.1-T_at 4.74450869 6.362980434
1194 1410.010.1-E_at 8.32156036 5.167245484
1195 57447.030.1-D_at 7.16110591 5.926932144
1196 1308.002.1-T_at 4.50117394 3.487272397
1197 4288.007.1-C_at 4.97101233 7.189192841
1198 244.011.1-T_at 5.29003948 3.948200539
1199 94274.003.1-B_at 4.42148503 3.46060704
1200 3178.003.1-E_at 6.30358046 5.181900836
1201 7153.002.4-T_at 4.03542364 6.008249752
1202 9055.012.1-D_at 4.02757905 6.120371884
1203 9232.001.1-E_at 5.22181281 7.208579638
1204 79068.011.2-B_at 6.64417255 5.308326918
1205 120.005.2-F_at 9.06074824 6.73592483
1206 7534.001.1-C_at 8.71480548 9.492140995
1207 120.005.2-T_at 8.73626834 6.165418999
1208 7373.003.3-C_at 4.85399243 3.462673564
1209 57447.004.2-D_at 6.16627621 4.604091159
1210 2568.005.1-F_at 4.73444224 3.560755491
1211 1308.001.1-E_at 4.41347272 3.418435324
1212 6876.020.1-F_at 6.2728158 4.761356719
1213 79971.014.1-D_at 6.31129325 4.294251993
1214 5621.008.1-D_at 5.98900704 4.179299085
1215 55732.003.2-T_at 3.81867845 5.173615902
1216 221120.006.1-D 8.08525795 7.079961293
1217 23266.008.1-T_at 6.70366212 4.807135334
1218 2335.045.1-F_at 4.39135516 6.494344728
1219 7170.007.1-F_at 7.64167879 8.466704716
1220 10461.002.1-B_at 4.77990896 3.622574749
1221 59.031.2-F_at 5.912075 4.730239133
1222 9055.010.1-T_at 4.95064392 6.677393383
1223 58499.005.2-F_at 5.8908337 4.132220814
1224 54443.006.2-F_at 3.53549616 5.526168717
1225 59.016.1-B_at 5.96979167 4.589590519
1226 4288.004.1-C_at 4.97220803 6.791619005
1227 7170.014.1-C_at 10.3731633 11.0837507
1228 7170.007.1-D_at 10.3462783 11.09055128
EXAMPLE III Molecular Prediction for Breast Cancer Diagnosis: Validation Set
A validation set was carried-out that included overall 71 samples. Of these, 21 and 50 were benign lesions and breast cancer respectively. Using this dataset, the inventors assessed the performances of the 1228 signature probes to predict for breast cancer as opposed to benign lesions. Overall 68 out of 71 samples were accurately classified (96%). Sensitivity and specificity of the tests were 96% (95% CI: 90.5-100) and 95% (95% CI: 86.1-100). The correlation of each specimen with the malignant and benign profile is reported in FIG. 6. Of the three misclassified specimen, one corresponded to a benign tumor (inflammatory granulomatosis) classified as malignant, and two were malignant tumors classified as benign by molecular predictor.
The inventors then evaluated the add-value of molecular predictor to cytological exam, and to a model that included classification of American College of Radiology (ACR) and age. Cytological exam failed to provide a definitive diagnosis in 5 out of 71 patients. Four out of these 5 patients were accurately classified by the molecular predictor. The proportion of explained variation (PEV) by Clinical model (age and ACR) was 75%+−8%, while the PEV by molecular predictor was 81% (+/−10%). When clinical model and molecular predictor were combined, the PEV was 87% (+/−7%), suggesting that molecular predictor presented an add-value of 12% (+/−7%) to the clinical model.
Using the top 50 polynucleotide probe sets: 1 out of 21 samples from patients with benign status were misclassified and 8 out of 50 samples from patients with malignant status.
Using the top 100 polynucleotide probe sets: 1 out of 21 samples from patients with benign status were misclassified and 7 out of 50 samples from patients with malignant status.
Using the top 150 polynucleotide probe sets: 1 out of 21 samples from patients with benign status were misclassified and 10 out of 50 samples from patients with malignant status.
Using the top 200 polynucleotide probe sets: 1 out of 21 samples from patients with benign status were misclassified and 7 out of 50 samples from patients with malignant status.
These data demonstrate that top probe set, even if some misclassifications occur, gives a good prognosis for a breast tumor.
Moreover, the use of the 1228, or 1640, polynucleotide probe sets according to the invention allows, without ambiguity, and misclassification, to determine if a breast tumor is benign or malignant.
Discussion
In the present study, the inventors have reported the exonic portrait of breast malignancy. The analysis of differential exonic events between malignant and benign lesions provides a complete picture of genomic anomalies associated with breast malignancy. The present study reveals a high level of genomic dysregulation between malignant and benign breast lesions. The inventors found out that 56652 out of 703680 evidenced probes (8%) were different among the two conditions. When the analysis focused on gene expression level (geo mean of probe sets), 3733 out of 20649 genes (7%) were differentially expressed between malignant and benign lesions. Analysis of gene expression levels revealed overexpression of candidate genes for further investigations. Pituitary Tumor Transforming 1 (PTTG1) has been previously reported to be overexpressed in pituitary tumors, thyroid cancer, colon cancer and glioma and to mediate malignant transformation (Vlotides G, Eigler T, Melmed S. Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev. 2007 April; 28(2):165-86). Neuroepithelial cell transforming gene 1 (NET1) is a guanine exchange factor that has been reported to mediate oncogenic transformation through activation of RhoA (Chan A M, Takai S, Yamada K, Miki T. Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning. Oncogene. 1996 Mar. 21; 12(6):1259-66). Pathway analysis revealed that genes involved in spliceosome assemble were enriched in the malignant condition. Spliceosome mediates alternative splicing, a phenomenon involved in oncogenesis (Lønning P E, Knappskog S, Staalesen V, Chrisanthar R, Lillehaug J R. Breast cancer prognostication and prediction in the postgenomic era. Ann Oncol. 2007 August; 18(8):1293-306; Pajares M J, Ezponda T, Catena R, Calvo A, Pio R, Montuenga L M. Alternative splicing: an emerging topic in molecular and clinical oncology. Lancet Oncol. 2007 April; 8(4):349-57). Present study suggests that alternative splicing could significantly contribute to the molecular profile of breast cancer. Based on this consideration, the inventors further evaluated to what extent analyses at exonic level could provide additional information to the ones provided by analyses at gene expression level.
The inventors identified that 2675 exon-probes that did not belong to genes identified as differentially expressed, actually presented a significantly higher intensity in breast cancer. A high proportion of these 2675 exon-probes presented a significantly increased splice index in breast cancer as compared to benign tumors. These exon-probes were considered to present a higher difference of intensity between cancer and benign lesions, as compared to the one of their relative genes. Several of these exons are located within genes linked to cancer biology (casein kinase 1, delta (Gao Z H, Seeling J M, Hill V, Yochum A, Virshup D M. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci USA. 2002 Feb. 5; 99(3):1182-), retinoblastoma binding protein 9 (Woitach J T, Zhang M, Niu C H, Thorgeirsson S S. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 August; 19(4):371-4) and ERB2 interacting protein (Jaulin-Bastard F, Arsanto J P, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni M J, Birnbaum D, Borg J P. Interaction between Erbin and a Catenin related protein in epithelial cells. J Biol Chem. 2002 Jan. 25; 277(4):2869-75)). These data point out the limits of analyses at gene expression level to define the transcriptional profile of diseases, and suggest that analysis at exon level could capture biological information that is missed by analysis at gene expression level.
Based on the finding that breast cancer presents a widely different exonic profile as compared to benign tumors, the inventors evaluated whether this technology could be used for breast cancer diagnosis. Pathologic exam of tumor biopsy is the gold standard for cancer diagnosis. Nevertheless, such approach presents several limitations including the need for invasive procedures and, in some tumor types, misdiagnosis. In the present study, the inventors have shown that a large scale molecular analysis based on fine needle aspiration could allow breast cancer diagnosis. This finding opens new ways in the field of cancer diagnosis. Applied to breast cancer, it could allow a more effective post-screening pattern of care by increasing the metric performances of fine needle aspiration. Although biopsy is the current gold standard for breast cancer diagnosis, it is associated with both morbidity and treatment delays (Meunier M, Clough K. Fine needle aspiration cytology versus percutaneous biopsy of nonpalpable breast lesions. Eur J Radiol. 2002 April; 42(1):10-6). Fine needle aspiration is a safer and easier approach but is associated with a high rate of false negative results. In the present study, molecular diagnosis by a 1228-probe signature using FNA samples was associated with 100% accuracy in a training set and 96% accuracy in a validation set. Interestingly, molecular classifier provided accurate diagnosis in 4 out of 5 samples for which the cytological exam was not conclusive. Altogether, these data suggested that the 1228-probe signature could be a complementary tool to cytological exam for the breast cancer diagnosis. This tool could allow avoiding biopsies and unnecessary surgery in patients with benign lesions of the breast. At the opposite, for malignant lesions, this approach could speed-up the diagnosis and could allow decreasing time to surgery. The development of molecular assays for cancer diagnosis could be of special interest in other tumor types. As illustration, the benign nature of thyroid nodules is often difficult to be determined preoperatively, leading to unnecessary surgeries (Poller D N, Stelow E B, Yiangou C. Thyroid FNAC cytology: can we do it better? Cytopathology. 2008 February; 19(1):4-10). A molecular assay could dramatically decrease the need for surgery in this setting.
Overall, the present study reports the full description of exons differentially expressed between breast malignant and benign tumors. These data allowed the identification of candidate genes (PTTG1, NET1) for further functional validation in breast cancer. In addition it suggests that alternative splicing significantly contributes the molecular profile of breast cancer, leading to the identification of exons with a significantly higher splice index in cancer, but located within unchanged gene.
Finally, the splice array technology allowed the development of an exon signature for breast cancer diagnosis.
Lengthy table referenced here
US08299233-20121030-T00001
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Lengthy table referenced here
US08299233-20121030-T00002
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LENGTHY TABLES
The patent contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US08299233B2). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Claims (12)

1. A combination of 50 polynucleotide probe sets,
said 50 polynucleotide probe sets comprising:
probe set #1 consisting of the nucleic acids consisting of SEQ ID NO: 333, 335 and 334;
probe set #2 consisting of the nucleic acids consisting of SEQ ID NO: 364, 365 and 366;
probe set #3 consisting of the nucleic acids consisting of SEQ ID NO: 364, 366 and 365;
probe set #4 consisting of the nucleic acids consisting of SEQ ID NO: 312, 348 and 313;
probe set #5 consisting of the nucleic acids consisting of SEQ ID NO: 312, 314 and 313;
probe set #6 consisting of the nucleic acids consisting of SEQ ID NO: 171, 172 and 173;
probe set #7 consisting of the nucleic acids consisting of SEQ ID NO: 315, 336 and 331;
probe set #8 consisting of the nucleic acids consisting of SEQ ID NO: 1198, 1199 and 1200;
probe set #9 consisting of the nucleic acids consisting of SEQ ID NO: 315, 317 and 316;
probe set #10 consisting of the nucleic acids consisting of SEQ ID NO: 1522, 1523 and 1524;
probe set #11 consisting of the nucleic acids consisting of SEQ ID NO: 339, 341 and 340;
probe set #12 consisting of the nucleic acids consisting of SEQ ID NO: 353, 361 and 360;
probe set #13 consisting of the nucleic acids consisting of SEQ ID NO: 1185, 1186 and 1194;
probe set #14 consisting of the nucleic acids consisting of SEQ ID NO: 315, 370 and 316;
probe set #15 consisting of the nucleic acids consisting of SEQ ID NO: 324, 326 and 325;
probe set #16 consisting of the nucleic acids consisting of SEQ ID NO: 1165 and 1166;
probe set #17 consisting of the nucleic acid consisting of SEQ ID NO: 177;
probe set #18 consisting of the nucleic acids consisting of SEQ ID NO: 1551, 1552 and 1553;
probe set #19 consisting of the nucleic acids consisting of SEQ ID NO: 315, 316 and 370;
probe set #20 consisting of the nucleic acids consisting of SEQ ID NO: 1185, 1186 and 1194;
probe set #21 consisting of the nucleic acids consisting of SEQ ID NO: 1523, 1524 and 1557;
probe set #22 consisting of the nucleic acid consisting of SEQ ID NO: 1158;
probe set #23 consisting of the nucleic acids consisting of SEQ ID NO: 345, 347 and 346;
probe set #24 consisting of the nucleic acids consisting of SEQ ID NO: 367, 369 and 368;
probe set #25 consisting of the nucleic acids consisting of SEQ ID NO: 315, 331 and 330;
probe set #26 consisting of the nucleic acids consisting of SEQ ID NO: 327, 329 and 328;
probe set #27 consisting of the nucleic acid consisting of SEQ ID NO: 1203;
probe set #28 consisting of the nucleic acids consisting of SEQ ID NO: 1262, 1263 and 1264;
probe set #29 consisting of the nucleic acids consisting of SEQ ID NO: 1534, 1535 and 1536;
probe set #30 consisting of the nucleic acids consisting of SEQ ID NO: 2179, 2180 and 2181;
probe set #31 consisting of the nucleic acids consisting of SEQ ID NO: 1159, 1160 and 1161;
probe set #32 consisting of the nucleic acids consisting of SEQ ID NO: 327, 329 and 328;
probe set #33 consisting of the nucleic acids consisting of SEQ ID NO: 157, 158 and 159;
probe set #34 consisting of the nucleic acids consisting of SEQ ID NO: 1267, 1268 and 1269;
probe set #35 consisting of the nucleic acids consisting of SEQ ID NO: 167, 168 and 169;
probe set #36 consisting of the nucleic acids consisting of SEQ ID NO: 167, 168 and 177;
probe set #37 consisting of the nucleic acids consisting of SEQ ID NO: 1167, 1168 and 1169;
probe set #38 consisting of the nucleic acids consisting of SEQ ID NO: 1544, 1545 and 1546;
probe set #39 consisting of the nucleic acids consisting of SEQ ID NO: 969, 972 and 981;
probe set #40 consisting of the nucleic acids consisting of SEQ ID NO: 1162, 1170 and 1171;
probe set #41 consisting of the nucleic acids consisting of SEQ ID NO: 790, 791 and 792;
probe set #42 consisting of the nucleic acids consisting of SEQ ID NO: 368, 374 and 375;
probe set #43 consisting of the nucleic acids consisting of SEQ ID NO: 1551, 1552 and 1553;
probe set #44 consisting of the nucleic acids consisting of SEQ ID NO: 1554, 1555 and 1556;
probe set #45 consisting of the nucleic acids consisting of SEQ ID NO: 2026, 2027 and 2028;
probe set #46 consisting of the nucleic acids consisting of SEQ ID NO: 1081, 1082 and 1083;
probe set #47 consisting of the nucleic acids consisting of SEQ ID NO: 1129, 1140 and 1141;
probe set #48 consisting of the nucleic acids consisting of SEQ ID NO: 1519, 1520 and 1521;
probe set #49 consisting of the nucleic acids consisting of SEQ ID NO: 136, 137 and 138; and
probe set #50 consisting of the nucleic acids consisting of SEQ ID NO: 793, 794 and 795.
2. The combination according to claim 1, comprising 100 polynucleotide probe sets,
said 100 polynucleotide probe sets comprising probe set #1 to probe set #50, and
probe set #51 consisting of the nucleic acids consisting of SEQ ID NO: 1075; 1076 and 1077;
probe set #52 consisting of the nucleic acids consisting of SEQ ID NO: 369 and 376;
probe set #53 consisting of the nucleic acids consisting of SEQ ID NO: 1509; 1510 and 1511;
probe set #54 consisting of the nucleic acids consisting of SEQ ID NO: 1528 and 1529;
probe set #55 consisting of the nucleic acids consisting of SEQ ID NO: 2176; 2177 and 2178;
probe set #56 consisting of the nucleic acids consisting of SEQ ID NO: 2023; 2024 and 2025;
probe set #57 consisting of the nucleic acids consisting of SEQ ID NO: 1162; 1180 and 1181;
probe set #58 consisting of the nucleic acids consisting of SEQ ID NO: 367 and 378;
probe set #59 consisting of the nucleic acids consisting of SEQ ID NO: 971;
probe set #60 consisting of the nucleic acids consisting of SEQ ID NO: 788 and 789;
probe set #61 consisting of the nucleic acids consisting of SEQ ID NO: 349; 361 and 350;
probe set #62 consisting of the nucleic acids consisting of SEQ ID NO: 1519; 1520 and 1521;
probe set #63 consisting of the nucleic acids consisting of SEQ ID NO: 555; 556 and 557;
probe set #64 consisting of the nucleic acids consisting of SEQ ID NO: 154; 155 and 156;
probe set #65 consisting of the nucleic acids consisting of SEQ ID NO: 317; 338 and 337;
probe set #66 consisting of the nucleic acids consisting of SEQ ID NO: 1201; 1202 and 1203;
probe set #67 consisting of the nucleic acids consisting of SEQ ID NO: 1187; 1188 and 1189;
probe set #68 consisting of the nucleic acids consisting of SEQ ID NO: 1129; 1130 and 1131;
probe set #69 consisting of the nucleic acids consisting of SEQ ID NO: 821; 822 and 823;
probe set #70 consisting of the nucleic acids consisting of SEQ ID NO: 558; 566 and 567;
probe set #71 consisting of the nucleic acids consisting of SEQ ID NO: 800; 801 and 802;
probe set #72 consisting of the nucleic acids consisting of SEQ ID NO: 2762; 2763 and 2764;
probe set #73 consisting of the nucleic acids consisting of SEQ ID NO: 1190; 1191 and 1192;
probe set #74 consisting of the nucleic acids consisting of SEQ ID NO: 1103; 1104 and 1105;
probe set #75 consisting of the nucleic acids consisting of SEQ ID NO: 2860; 2861 and 2862;
probe set #76 consisting of the nucleic acids consisting of SEQ ID NO: 1524; 1561 and 1562;
probe set #77 consisting of the nucleic acids consisting of SEQ ID NO: 1195 and 1196;
probe set #78 consisting of the nucleic acids consisting of SEQ ID NO: 315; 331; 330;
probe set #79 consisting of the nucleic acids consisting of SEQ ID NO: 120;
probe set #80 consisting of the nucleic acids consisting of SEQ ID NO: 821; 822 and 823;
probe set #81 consisting of the nucleic acids consisting of SEQ ID NO: 1162; 1163 and 1164;
probe set #82 consisting of the nucleic acids consisting of SEQ ID NO: 379; 380 and 381;
probe set #83 consisting of the nucleic acids consisting of SEQ ID NO: 1519; 1520 and 1521;
probe set #84 consisting of the nucleic acids consisting of SEQ ID NO: 354; 356 and 355;
probe set #85 consisting of the nucleic acids consisting of SEQ ID NO: 1087; 1088 and 1089;
probe set #86 consisting of the nucleic acids consisting of SEQ ID NO: 332;
probe set #87 consisting of the nucleic acids consisting of SEQ ID NO: 328; 371 and 363;
probe set #88 consisting of the nucleic acids consisting of SEQ ID NO: 1123; 1124 and 1125;
probe set #89 consisting of the nucleic acids consisting of SEQ ID NO: 2173; 2174 and 2175;
probe set #90 consisting of the nucleic acids consisting of SEQ ID NO: 1193; 1194 and 1207;
probe set #91 consisting of the nucleic acids consisting of SEQ ID NO: 1682; 1683 and 1684;
probe set #92 consisting of the nucleic acids consisting of SEQ ID NO: 1776; 1777 and 1778;
probe set #93 consisting of the nucleic acids consisting of SEQ ID NO: 1163; 1164 and 1172;
probe set #94 consisting of the nucleic acids consisting of SEQ ID NO: 1114; 1115 and 1116;
probe set #95 consisting of the nucleic acids consisting of SEQ ID NO: 2883; 2884 and 2885;
probe set #96 consisting of the nucleic acids consisting of SEQ ID NO: 1187; 1188 and 1189;
probe set #97 consisting of the nucleic acids consisting of SEQ ID NO: 174; 175 and 176;
probe set #98 consisting of the nucleic acids consisting of SEQ ID NO: 560; 561 and 562;
probe set #99 consisting of the nucleic acids consisting of SEQ ID NO: 1056; 1057 and 1058; and
probe set #100 consisting of the nucleic acids consisting of SEQ ID NO: 351; 353 and 352.
3. The combination according to claim 2, comprising 150 polynucleotide probe sets, said 150 polynucleotide probe sets comprising probe set #1 to probe set #100, and
probe set #101 consisting of the nucleic acids consisting of SEQ ID NO: 1315; 2599 and 2600;
probe set #102 consisting of the nucleic acids consisting of SEQ ID NO: 1690; 1691 and 1692;
probe set #103 consisting of the nucleic acids consisting of SEQ ID NO: 1199;
probe set #104 consisting of the nucleic acids consisting of SEQ ID NO: 788; 796 and 797;
probe set #105 consisting of the nucleic acids consisting of SEQ ID NO: 1057; 1058 and 1080;
probe set #106 consisting of the nucleic acids consisting of SEQ ID NO: 1469; 1470 and 1471;
probe set #107 consisting of the nucleic acids consisting of SEQ ID NO: 798; 799 and 801;
probe set #108 consisting of the nucleic acids consisting of SEQ ID NO: 1788; 1789 and 1790;
probe set #109 consisting of the nucleic acids consisting of SEQ ID NO: 1550;
probe set #110 consisting of the nucleic acids consisting of SEQ ID NO: 806; 807 and 808;
probe set #111 consisting of the nucleic acids consisting of SEQ ID NO: 1061; 1062 and 1063;
probe set #112 consisting of the nucleic acids consisting of SEQ ID NO: 788; 796 and 797;
probe set #113 consisting of the nucleic acids consisting of SEQ ID NO: 2576; 2577 and 2578;
probe set #114 consisting of the nucleic acids consisting of SEQ ID NO: 1580; 1581 and 1582;
probe set #115 consisting of the nucleic acids consisting of SEQ ID NO: 968; 969 and 970;
probe set #116 consisting of the nucleic acids consisting of SEQ ID NO: 1469; 1470 and 1471;
probe set #117 consisting of the nucleic acids consisting of SEQ ID NO: 1064; 1065 and 1066;
probe set #118 consisting of the nucleic acids consisting of SEQ ID NO: 1558; 1559 and 1560;
probe set #119 consisting of the nucleic acids consisting of SEQ ID NO: 362; 371 and 363;
probe set #120 consisting of the nucleic acids consisting of SEQ ID NO: 197; 1139 and 1141;
probe set #121 consisting of the nucleic acids consisting of SEQ ID NO: 1537; 1538 and 1539;
probe set #122 consisting of the nucleic acids consisting of SEQ ID NO: 803; 804 and 805;
probe set #123 consisting of the nucleic acids consisting of SEQ ID NO: 513; 514 and 515;
probe set #124 consisting of the nucleic acids consisting of SEQ ID NO: 1067; 1068 and 1069;
probe set #125 consisting of the nucleic acids consisting of SEQ ID NO: 812; 813 and 814;
probe set #126 consisting of the nucleic acids consisting of SEQ ID NO: 2196 and 2201;
probe set #127 consisting of the nucleic acids consisting of SEQ ID NO: 558; 559 and 567;
probe set #128 consisting of the nucleic acids consisting of SEQ ID NO: 248; 254 and 255;
probe set #129 consisting of the nucleic acids consisting of SEQ ID NO: 368 and 377;
probe set #130 consisting of the nucleic acids consisting of SEQ ID NO: 2536; 2537 and 2538;
probe set #131 consisting of the nucleic acids consisting of SEQ ID NO: 4; 5 and 6;
probe set #132 consisting of the nucleic acids consisting of SEQ ID NO: 2065; 2067 and 2091;
probe set #133 consisting of the nucleic acids consisting of SEQ ID NO: 1671; 1685 and 1686;
probe set #134 consisting of the nucleic acids consisting of SEQ ID NO: 1174; 1175 and 1176;
probe set #135 consisting of the nucleic acids consisting of SEQ ID NO: 783; 784 and 785;
probe set #136 consisting of the nucleic acids consisting of SEQ ID NO: 2774; 2775 and 2776;
probe set #137 consisting of the nucleic acids consisting of SEQ ID NO: 305; 307 and 306;
probe set #138 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #139 consisting of the nucleic acids consisting of SEQ ID NO: 806; 807 and 808;
probe set #140 consisting of the nucleic acids consisting of SEQ ID NO: 1162; 1284 and 1285;
probe set #141 consisting of the nucleic acids consisting of SEQ ID NO: 1204; 1205 and 1206;
probe set #142 consisting of the nucleic acids consisting of SEQ ID NO: 1197;
probe set #143 consisting of the nucleic acids consisting of SEQ ID NO: 2229; 2230 and 2231;
probe set #144 consisting of the nucleic acids consisting of SEQ ID NO: 1963;
probe set #145 consisting of the nucleic acids consisting of SEQ ID NO: 1890; 1891 and 1892;
probe set #146 consisting of the nucleic acids consisting of SEQ ID NO: 813; 814 and 818;
probe set #147 consisting of the nucleic acids consisting of SEQ ID NO: 2088; 2089 and 2090;
probe set #148 consisting of the nucleic acids consisting of SEQ ID NO: 1515; 1516 and 1517;
probe set #149 consisting of the nucleic acids consisting of SEQ ID NO: 1056; 1070 and 1071; and
probe set #150 consisting of the nucleic acids consisting of SEQ ID NO: 552; 553 and 554.
4. The combination according to claim 3, comprising 200 polynucleotide probe sets,
said 200 polynucleotide probe sets comprising probe set #1 to probe set #150, and
probe set #151 consisting of the nucleic acids consisting of SEQ ID NO: 972; 973 and 974;
probe set #152 consisting of the nucleic acids consisting of SEQ ID NO: 845; 846 and 847;
probe set #153 consisting of the nucleic acids consisting of SEQ ID NO: 815; 816 and 817;
probe set #154 consisting of the nucleic acids consisting of SEQ ID NO: 195; 196 and 868;
probe set #155 consisting of the nucleic acids consisting of SEQ ID NO: 1512; 1513 and 1514;
probe set #156 consisting of the nucleic acids consisting of SEQ ID NO: 1162; 1284 and 1285;
probe set #157 consisting of the nucleic acids consisting of SEQ ID NO: 2088; 2089 and 2090;
probe set #158 consisting of the nucleic acids consisting of SEQ ID NO: 1335;
probe set #159 consisting of the nucleic acids consisting of SEQ ID NO: 1123; 1124 and 1125;
probe set #160 consisting of the nucleic acids consisting of SEQ ID NO: 840; 841 and 845;
probe set #161 consisting of the nucleic acids consisting of SEQ ID NO: 1084; 1085 and 1086;
probe set #162 consisting of the nucleic acids consisting of SEQ ID NO: 198; 199 and 200;
probe set #163 consisting of the nucleic acids consisting of SEQ ID NO: 824; 825 and 826;
probe set #164 consisting of the nucleic acids consisting of SEQ ID NO: 809; 810 and 811;
probe set #165 consisting of the nucleic acids consisting of SEQ ID NO: 1586; 1587 and 1588;
probe set #166 consisting of the nucleic acids consisting of SEQ ID NO: 2794;
probe set #167 consisting of the nucleic acids consisting of SEQ ID NO: 1094; 1095 and 1096;
probe set #168 consisting of the nucleic acids consisting of SEQ ID NO: 2778; 2779 and 2783;
probe set #169 consisting of the nucleic acids consisting of SEQ ID NO: 1162; 1284 and 1285;
probe set #170 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #171 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #172 consisting of the nucleic acids consisting of SEQ ID NO: 1110; 1111 and 1112;
probe set #173 consisting of the nucleic acids consisting of SEQ ID NO: 2762; 2763 and 2764;
probe set #174 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1230 and 1242;
probe set #175 consisting of the nucleic acids consisting of SEQ ID NO: 1250; 1251 and 1252;
probe set #176 consisting of the nucleic acids consisting of SEQ ID NO: 1126; 1127 and 1128;
probe set #177 consisting of the nucleic acids consisting of SEQ ID NO: 2065; 2067 and 2091;
probe set #178 consisting of the nucleic acids consisting of SEQ ID NO: 2601; 2602 and 2603;
probe set #179 consisting of the nucleic acids consisting of SEQ ID NO: 2381; 2382 and 2383;
probe set #180 consisting of the nucleic acids consisting of SEQ ID NO: 1407 and 1408;
probe set #181 consisting of the nucleic acids consisting of SEQ ID NO: 2065; 2067 and 2068;
probe set #182 consisting of the nucleic acids consisting of SEQ ID NO: 130; 131 and 132;
probe set #183 consisting of the nucleic acids consisting of SEQ ID NO: 1194; 1265 and 1266;
probe set #184 consisting of the nucleic acids consisting of SEQ ID NO: 968; 969 and 970;
probe set #185 consisting of the nucleic acids consisting of SEQ ID NO: 1743; 1744 and 1745;
probe set #186 consisting of the nucleic acids consisting of SEQ ID NO: 1557; 1563 and 1564;
probe set #187 consisting of the nucleic acids consisting of SEQ ID NO: 1687; 1688 and 1689;
probe set #188 consisting of the nucleic acids consisting of SEQ ID NO: 1114; 1115 and 1116;
probe set #189 consisting of the nucleic acids consisting of SEQ ID NO: 2083; 2084 and 2085;
probe set #190 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2092;
probe set #191 consisting of the nucleic acids consisting of SEQ ID NO: 1586; 1587 and 1588;
probe set #192 consisting of the nucleic acids consisting of SEQ ID NO: 563; 564 and 565;
probe set #193 consisting of the nucleic acids consisting of SEQ ID NO: 1270; 1271 and 1272;
probe set #194 consisting of the nucleic acids consisting of SEQ ID NO: 1243; 1244 and 1245;
probe set #195 consisting of the nucleic acids consisting of SEQ ID NO: 1896; 1897 and 1898;
probe set #196 consisting of the nucleic acids consisting of SEQ ID NO: 1059; 1060 and 1085;
probe set #197 consisting of the nucleic acids consisting of SEQ ID NO: 1469; 1470 and 1471;
probe set #198 consisting of the nucleic acids consisting of SEQ ID NO: 121; 122 and 123;
probe set #199 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2063; and
probe set #200 consisting of the nucleic acids consisting of SEQ ID NO: 1974.
5. The combination according to claim 4, comprising 1228 polynucleotide probe sets,
said 1228 polynucleotide probe sets comprising probe set #1 to probe set #200, and
probe set #201 consisting of the nucleic acids consisting of SEQ ID NO: 246; 247 and 248;
probe set #202 consisting of the nucleic acids consisting of SEQ ID NO: 1243; 1244 and 1245;
probe set #203 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2103 and 2104;
probe set #204 consisting of the nucleic acids consisting of SEQ ID NO: 1284; 1489 and 1490;
probe set #205 consisting of the nucleic acids consisting of SEQ ID NO: 342; 344 and 343;
probe set #206 consisting of the nucleic acids consisting of SEQ ID NO: 2202; 2203 and 2204;
probe set #207 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1971;
probe set #208 consisting of the nucleic acids consisting of SEQ ID NO: 1293; 1294 and 1295;
probe set #209 consisting of the nucleic acids consisting of SEQ ID NO: 1515; 1517 and 1518;
probe set #210 consisting of the nucleic acids consisting of SEQ ID NO: 1193; 1194 and 1207;
probe set #211 consisting of the nucleic acids consisting of SEQ ID NO: 1068; 1078 and 1079;
probe set #212 consisting of the nucleic acids consisting of SEQ ID NO: 1243; 1244 and 1245;
probe set #213 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #214 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2103;
probe set #215 consisting of the nucleic acids consisting of SEQ ID NO: 2798; 2799 and 2800;
probe set #216 consisting of the nucleic acids consisting of SEQ ID NO: 1773; 1774 and 1775;
probe set #217 consisting of the nucleic acids consisting of SEQ ID NO: 2471; 2472 and 2473;
probe set #218 consisting of the nucleic acids consisting of SEQ ID NO: 1243; 1244 and 1245;
probe set #219 consisting of the nucleic acids consisting of SEQ ID NO: 1109;
probe set #220 consisting of the nucleic acids consisting of SEQ ID NO: 1547; 1548 and 1549;
probe set #221 consisting of the nucleic acids consisting of SEQ ID NO: 1525; 1526 and 1527;
probe set #222 consisting of the nucleic acids consisting of SEQ ID NO: 2193; 2196 and 2200;
probe set #223 consisting of the nucleic acids consisting of SEQ ID NO: 2212 and 2213;
probe set #224 consisting of the nucleic acids consisting of SEQ ID NO: 972; 973 and 974;
probe set #225 consisting of the nucleic acids consisting of SEQ ID NO: 841; 845 and 846;
probe set #226 consisting of the nucleic acids consisting of SEQ ID NO: 1243; 1244 and 1245;
probe set #227 consisting of the nucleic acids consisting of SEQ ID NO: 813; 819 and 820;
probe set #228 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2077 and 2089;
probe set #229 consisting of the nucleic acids consisting of SEQ ID NO: 1530; 1531 and 1532;
probe set #230 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #231 consisting of the nucleic acids consisting of SEQ ID NO: 786; 787 and 796;
probe set #232 consisting of the nucleic acids consisting of SEQ ID NO: 379; 380 and 381;
probe set #233 consisting of the nucleic acids consisting of SEQ ID NO: 1662; 1663 and 1664;
probe set #234 consisting of the nucleic acids consisting of SEQ ID NO: 560; 561 and 562;
probe set #235 consisting of the nucleic acids consisting of SEQ ID NO: 1174; 1175 and 1176;
probe set #236 consisting of the nucleic acids consisting of SEQ ID NO: 1177; 1178 and 1179;
probe set #237 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #238 consisting of the nucleic acids consisting of SEQ ID NO: 1187; 1188 and 1189;
probe set #239 consisting of the nucleic acids consisting of SEQ ID NO: 151; 152 and 153;
probe set #240 consisting of the nucleic acids consisting of SEQ ID NO: 2235; 2236 and 2237;
probe set #241 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1238 and 1253;
probe set #242 consisting of the nucleic acids consisting of SEQ ID NO: 446; 447 and 454;
probe set #243 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1242 and 1260;
probe set #244 consisting of the nucleic acids consisting of SEQ ID NO: 824; 825 and 826;
probe set #245 consisting of the nucleic acids consisting of SEQ ID NO: 848; 849 and 850;
probe set #246 consisting of the nucleic acids consisting of SEQ ID NO: 2058; 2059 and 2089;
probe set #247 consisting of the nucleic acids consisting of SEQ ID NO: 1475; 1476 and 1477;
probe set #248 consisting of the nucleic acids consisting of SEQ ID NO: 2533; 2534 and 2535;
probe set #249 consisting of the nucleic acids consisting of SEQ ID NO: 2192; 2193 and 2194;
probe set #250 consisting of the nucleic acids consisting of SEQ ID NO: 832; 833 and 834;
probe set #251 consisting of the nucleic acids consisting of SEQ ID NO: 1234 and 1235;
probe set #252 consisting of the nucleic acids consisting of SEQ ID NO: 1893; 1894 and 1895;
probe set #253 consisting of the nucleic acids consisting of SEQ ID NO: 1932; 1971 and 1987;
probe set #254 consisting of the nucleic acids consisting of SEQ ID NO: 2083; 2084 and 2085;
probe set #255 consisting of the nucleic acids consisting of SEQ ID NO: 264; 273 and 274;
probe set #256 consisting of the nucleic acids consisting of SEQ ID NO: 428;
probe set #257 consisting of the nucleic acids consisting of SEQ ID NO: 198; 199 and 200;
probe set #258 consisting of the nucleic acids consisting of SEQ ID NO: 2200; 2205 and 2206;
probe set #259 consisting of the nucleic acids consisting of SEQ ID NO: 2777; 2778 and 2779;
probe set #260 consisting of the nucleic acids consisting of SEQ ID NO: 1287; 1288 and 1289;
probe set #261 consisting of the nucleic acids consisting of SEQ ID NO: 446; 453 and 454;
probe set #262 consisting of the nucleic acids consisting of SEQ ID NO: 2192; 2193 and 2194;
probe set #263 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #264 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #265 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #266 consisting of the nucleic acids consisting of SEQ ID NO: 388; 389 and 390;
probe set #267 consisting of the nucleic acids consisting of SEQ ID NO: 1310; 1311 and 1312;
probe set #268 consisting of the nucleic acids consisting of SEQ ID NO: 1313; 1314 and 1315;
probe set #269 consisting of the nucleic acids consisting of SEQ ID NO: 1142; 1143 and 1144;
probe set #270 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1230 and 1242;
probe set #271 consisting of the nucleic acids consisting of SEQ ID NO: 972; 973 and 974;
probe set #272 consisting of the nucleic acids consisting of SEQ ID NO: 1673; 1674 and 1675;
probe set #273 consisting of the nucleic acids consisting of SEQ ID NO: 446; 453 and 454;
probe set #274 consisting of the nucleic acids consisting of SEQ ID NO: 2195; 2196 and 2197;
probe set #275 consisting of the nucleic acids consisting of SEQ ID NO: 2784;
probe set #276 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2103;
probe set #277 consisting of the nucleic acids consisting of SEQ ID NO: 459 and 460;
probe set #278 consisting of the nucleic acids consisting of SEQ ID NO: 1583; 1584 and 1585;
probe set #279 consisting of the nucleic acids consisting of SEQ ID NO: 1246; 1247 and 1248;
probe set #280 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2063 and 2068;
probe set #281 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #282 consisting of the nucleic acids consisting of SEQ ID NO: 170;
probe set #283 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2102;
probe set #284 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1238;
probe set #285 consisting of the nucleic acids consisting of SEQ ID NO: 127; 128 and 129;
probe set #286 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #287 consisting of the nucleic acids consisting of SEQ ID NO: 840; 841 and 845;
probe set #288 consisting of the nucleic acids consisting of SEQ ID NO: 840; 841 and 845;
probe set #289 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #290 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1253 and 1254;
probe set #291 consisting of the nucleic acids consisting of SEQ ID NO: 1369; 1370 and 1371;
probe set #292 consisting of the nucleic acids consisting of SEQ ID NO: 1239; 1240 and 1241;
probe set #293 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1242 and 1260;
probe set #294 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1253 and 1254;
probe set #295 consisting of the nucleic acids consisting of SEQ ID NO: 1515; 1517 and 1518;
probe set #296 consisting of the nucleic acids consisting of SEQ ID NO: 2307;
probe set #297 consisting of the nucleic acids consisting of SEQ ID NO: 246; 247 and 248;
probe set #298 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1218 and 1253;
probe set #299 consisting of the nucleic acids consisting of SEQ ID NO: 2059; 2100 and 2101;
probe set #300 consisting of the nucleic acids consisting of SEQ ID NO: 841; 845 and 846;
probe set #301 consisting of the nucleic acids consisting of SEQ ID NO: 1746; 1747 and 1748;
probe set #302 consisting of the nucleic acids consisting of SEQ ID NO: 1313; 1314 and 1315;
probe set #303 consisting of the nucleic acids consisting of SEQ ID NO: 845; 846 and 847;
probe set #304 consisting of the nucleic acids consisting of SEQ ID NO: 1942; 1943 and 1948;
probe set #305 consisting of the nucleic acids consisting of SEQ ID NO: 1047; 1048 and 1049;
probe set #306 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #307 consisting of the nucleic acids consisting of SEQ ID NO: 2483; 2484 and 2485;
probe set #308 consisting of the nucleic acids consisting of SEQ ID NO: 827 and 828;
probe set #309 consisting of the nucleic acids consisting of SEQ ID NO: 1943; 1948 and 1973;
probe set #310 consisting of the nucleic acids consisting of SEQ ID NO: 1039 and 1040;
probe set #311 consisting of the nucleic acids consisting of SEQ ID NO: 2558; 2559 and 2560;
probe set #312 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #313 consisting of the nucleic acids consisting of SEQ ID NO: 2058; 2059 and 2089;
probe set #314 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1238 and 1253;
probe set #315 consisting of the nucleic acids consisting of SEQ ID NO: 1239; 1240 and 1241;
probe set #316 consisting of the nucleic acids consisting of SEQ ID NO: 1256; 1257 and 1258;
probe set #317 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2068 and 2103;
probe set #318 consisting of the nucleic acids consisting of SEQ ID NO: 446; 453 and 454;
probe set #319 consisting of the nucleic acids consisting of SEQ ID NO: 422; 423 and 424;
probe set #320 consisting of the nucleic acids consisting of SEQ ID NO: 451; 452 and 454;
probe set #321 consisting of the nucleic acids consisting of SEQ ID NO: 2076; 2103 and 2108;
probe set #322 consisting of the nucleic acids consisting of SEQ ID NO: 139; 140 and 141;
probe set #323 consisting of the nucleic acids consisting of SEQ ID NO: 228; 229 and 230;
probe set #324 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1242 and 1260;
probe set #325 consisting of the nucleic acids consisting of SEQ ID NO: 2510; 2511 and 2512;
probe set #326 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2723 and 2759;
probe set #327 consisting of the nucleic acids consisting of SEQ ID NO: 1148; 1149 and 1150;
probe set #328 consisting of the nucleic acids consisting of SEQ ID NO: 1568; 1569 and 1570;
probe set #329 consisting of the nucleic acids consisting of SEQ ID NO: 1290; 1291 and 1292;
probe set #330 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2063 and 2068;
probe set #331 consisting of the nucleic acids consisting of SEQ ID NO: 1174; 1175 and 1176;
probe set #332 consisting of the nucleic acids consisting of SEQ ID NO: 1239; 1240 and 1241;
probe set #333 consisting of the nucleic acids consisting of SEQ ID NO: 761; 762 and 763;
probe set #334 consisting of the nucleic acids consisting of SEQ ID NO: 669; 670 and 671;
probe set #335 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1218 and 1253;
probe set #336 consisting of the nucleic acids consisting of SEQ ID NO: 1136; 1137 and 1138;
probe set #337 consisting of the nucleic acids consisting of SEQ ID NO: 1671; 1672 and 1685;
probe set #338 consisting of the nucleic acids consisting of SEQ ID NO: 1565; 1566 and 1567;
probe set #339 consisting of the nucleic acids consisting of SEQ ID NO: 308;
probe set #340 consisting of the nucleic acids consisting of SEQ ID NO: 1583; 1584 and 1585;
probe set #341 consisting of the nucleic acids consisting of SEQ ID NO: 1985;
probe set #342 consisting of the nucleic acids consisting of SEQ ID NO: 1583; 1584 and 1600;
probe set #343 consisting of the nucleic acids consisting of SEQ ID NO: 2520; 2521 and 2522;
probe set #344 consisting of the nucleic acids consisting of SEQ ID NO: 842; 843 and 844;
probe set #345 consisting of the nucleic acids consisting of SEQ ID NO: 1216; 1217 and 1218;
probe set #346 consisting of the nucleic acids consisting of SEQ ID NO: 837; 838 and 839;
probe set #347 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2068 and 2103;
probe set #348 consisting of the nucleic acids consisting of SEQ ID NO: 669; 670 and 671;
probe set #349 consisting of the nucleic acids consisting of SEQ ID NO: 1583; 1584 and 1585;
probe set #350 consisting of the nucleic acids consisting of SEQ ID NO: 2492; 2493 and 2494;
probe set #351 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1253 and 1261;
probe set #352 consisting of the nucleic acids consisting of SEQ ID NO: 1869; 1870 and 1871;
probe set #353 consisting of the nucleic acids consisting of SEQ ID NO: 1213; 1214 and 1215;
probe set #354 consisting of the nucleic acids consisting of SEQ ID NO: 318; 320 and 319;
probe set #355 consisting of the nucleic acids consisting of SEQ ID NO: 448; 449 and 450;
probe set #356 consisting of the nucleic acids consisting of SEQ ID NO: 2158; 2163 and 2164;
probe set #357 consisting of the nucleic acids consisting of SEQ ID NO: 971;
probe set #358 consisting of the nucleic acids consisting of SEQ ID NO: 1059; 1060 and 1093;
probe set #359 consisting of the nucleic acids consisting of SEQ ID NO: 2662; 2663 and 2664;
probe set #360 consisting of the nucleic acids consisting of SEQ ID NO: 125; 126 and 127;
probe set #361 consisting of the nucleic acids consisting of SEQ ID NO: 2069; 2070 and 2071;
probe set #362 consisting of the nucleic acids consisting of SEQ ID NO: 761; 762 and 763;
probe set #363 consisting of the nucleic acids consisting of SEQ ID NO: 1589; 1590 and 1591;
probe set #364 consisting of the nucleic acids consisting of SEQ ID NO: 2523;
probe set #365 consisting of the nucleic acids consisting of SEQ ID NO: 2760;
probe set #366 consisting of the nucleic acids consisting of SEQ ID NO: 2078 and 2079;
probe set #367 consisting of the nucleic acids consisting of SEQ ID NO: 197; 868 and 1139;
probe set #368 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1242 and 1260;
probe set #369 consisting of the nucleic acids consisting of SEQ ID NO: 429; 430 and 431;
probe set #370 consisting of the nucleic acids consisting of SEQ ID NO: 845; 846 and 847;
probe set #371 consisting of the nucleic acids consisting of SEQ ID NO: 1472; 1473 and 1474;
probe set #372 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2063;
probe set #373 consisting of the nucleic acids consisting of SEQ ID NO: 1478; 1479 and 1480;
probe set #374 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1242 and 1260;
probe set #375 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1962;
probe set #376 consisting of the nucleic acids consisting of SEQ ID NO: 304;
probe set #377 consisting of the nucleic acids consisting of SEQ ID NO: 2064; 2065 and 2066;
probe set #378 consisting of the nucleic acids consisting of SEQ ID NO: 1229; 1242 and 1260;
probe set #379 consisting of the nucleic acids consisting of SEQ ID NO: 1218; 1242 and 1260;
probe set #380 consisting of the nucleic acids consisting of SEQ ID NO: 2928; 2929 and 2930;
probe set #381 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #382 consisting of the nucleic acids consisting of SEQ ID NO: 246; 247 and 248;
probe set #383 consisting of the nucleic acids consisting of SEQ ID NO: 2069; 2070 and 2071;
probe set #384 consisting of the nucleic acids consisting of SEQ ID NO: 1952; 1953 and 1954;
probe set #385 consisting of the nucleic acids consisting of SEQ ID NO: 538; 539 and 540;
probe set #386 consisting of the nucleic acids consisting of SEQ ID NO: 160;
probe set #387 consisting of the nucleic acids consisting of SEQ ID NO: 722; 723 and 724;
probe set #388 consisting of the nucleic acids consisting of SEQ ID NO: 702; 703 and 704;
probe set #389 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #390 consisting of the nucleic acids consisting of SEQ ID NO: 2513;
probe set #391 consisting of the nucleic acids consisting of SEQ ID NO: 2338; 2339 and 2340;
probe set #392 consisting of the nucleic acids consisting of SEQ ID NO: 869; 873 and 874;
probe set #393 consisting of the nucleic acids consisting of SEQ ID NO: 1299; 1300 and 1301;
probe set #394 consisting of the nucleic acids consisting of SEQ ID NO: 2886; 2887 and 2888;
probe set #395 consisting of the nucleic acids consisting of SEQ ID NO: 2099;
probe set #396 consisting of the nucleic acids consisting of SEQ ID NO: 2471; 2472 and 2473;
probe set #397 consisting of the nucleic acids consisting of SEQ ID NO: 1679; 1680 and 1681;
probe set #398 consisting of the nucleic acids consisting of SEQ ID NO: 841; 845 and 846;
probe set #399 consisting of the nucleic acids consisting of SEQ ID NO: 1113;
probe set #400 consisting of the nucleic acids consisting of SEQ ID NO: 1592; 1593 and 1594;
probe set #401 consisting of the nucleic acids consisting of SEQ ID NO: 2338; 2339 and 2340;
probe set #402 consisting of the nucleic acids consisting of SEQ ID NO: 2483; 2484 and 2485;
probe set #403 consisting of the nucleic acids consisting of SEQ ID NO: 2300; 2301 and 2302;
probe set #404 consisting of the nucleic acids consisting of SEQ ID NO: 2548; 2549 and 2550;
probe set #405 consisting of the nucleic acids consisting of SEQ ID NO: 1939; 1940 and 1941;
probe set #406 consisting of the nucleic acids consisting of SEQ ID NO: 195; 196 and 197;
probe set #407 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2103 and 2104;
probe set #408 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #409 consisting of the nucleic acids consisting of SEQ ID NO: 1382; 1383 and 1384;
probe set #410 consisting of the nucleic acids consisting of SEQ ID NO: 1943; 1948 and 1978;
probe set #411 consisting of the nucleic acids consisting of SEQ ID NO: 2927;
probe set #412 consisting of the nucleic acids consisting of SEQ ID NO: 1920 and 1921;
probe set #413 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2063 and 2068;
probe set #414 consisting of the nucleic acids consisting of SEQ ID NO: 1686; 1693 and 1694;
probe set #415 consisting of the nucleic acids consisting of SEQ ID NO: 1217; 1236 and 1237;
probe set #416 consisting of the nucleic acids consisting of SEQ ID NO: 755; 756 and 757;
probe set #417 consisting of the nucleic acids consisting of SEQ ID NO: 2372; 2373 and 2374;
probe set #418 consisting of the nucleic acids consisting of SEQ ID NO: 1595; 1596 and 1597;
probe set #419 consisting of the nucleic acids consisting of SEQ ID NO: 1193; 1208 and 1209;
probe set #420 consisting of the nucleic acids consisting of SEQ ID NO: 2049; 2050 and 2051;
probe set #421 consisting of the nucleic acids consisting of SEQ ID NO: 1193; 1194 and 1207;
probe set #422 consisting of the nucleic acids consisting of SEQ ID NO: 265; 266 and 267;
probe set #423 consisting of the nucleic acids consisting of SEQ ID NO: 1580; 1581 and 1582;
probe set #424 consisting of the nucleic acids consisting of SEQ ID NO: 146; 147 and 150;
probe set #425 consisting of the nucleic acids consisting of SEQ ID NO: 1662; 1663 and 1664;
probe set #426 consisting of the nucleic acids consisting of SEQ ID NO: 1242; 1249 and 1268;
probe set #427 consisting of the nucleic acids consisting of SEQ ID NO: 2791; 2792 and 2793;
probe set #428 consisting of the nucleic acids consisting of SEQ ID NO: 124;
probe set #429 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2103;
probe set #430 consisting of the nucleic acids consisting of SEQ ID NO: 1649; 1650 and 1651;
probe set #431 consisting of the nucleic acids consisting of SEQ ID NO: 703; 711 and 736;
probe set #432 consisting of the nucleic acids consisting of SEQ ID NO: 1927; 1932 and 1987;
probe set #433 consisting of the nucleic acids consisting of SEQ ID NO: 2086 and 2087;
probe set #434 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #435 consisting of the nucleic acids consisting of SEQ ID NO: 840; 841 and 845;
probe set #436 consisting of the nucleic acids consisting of SEQ ID NO: 197; 868 and 1132;
probe set #437 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2065 and 2072;
probe set #438 consisting of the nucleic acids consisting of SEQ ID NO: 842; 843 and 844;
probe set #439 consisting of the nucleic acids consisting of SEQ ID NO: 1306;
probe set #440 consisting of the nucleic acids consisting of SEQ ID NO: 2214 and 2215;
probe set #441 consisting of the nucleic acids consisting of SEQ ID NO: 1284; 1290 and 1489;
probe set #442 consisting of the nucleic acids consisting of SEQ ID NO: 298; 300 and 299;
probe set #443 consisting of the nucleic acids consisting of SEQ ID NO: 2106;
probe set #444 consisting of the nucleic acids consisting of SEQ ID NO: 986;
probe set #445 consisting of the nucleic acids consisting of SEQ ID NO: 2049; 2050 and 2051;
probe set #446 consisting of the nucleic acids consisting of SEQ ID NO: 2206; 2207 and 2208;
probe set #447 consisting of the nucleic acids consisting of SEQ ID NO: 2527; 2528 and 2529;
probe set #448 consisting of the nucleic acids consisting of SEQ ID NO: 1259;
probe set #449 consisting of the nucleic acids consisting of SEQ ID NO: 2677; 2678 and 2708;
probe set #450 consisting of the nucleic acids consisting of SEQ ID NO: 1217; 1236 and 1237;
probe set #451 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2102;
probe set #452 consisting of the nucleic acids consisting of SEQ ID NO: 2369; 2370 and 2371;
probe set #453 consisting of the nucleic acids consisting of SEQ ID NO: 696; 697 and 698;
probe set #454 consisting of the nucleic acids consisting of SEQ ID NO: 1255;
probe set #455 consisting of the nucleic acids consisting of SEQ ID NO: 265; 266 and 267;
probe set #456 consisting of the nucleic acids consisting of SEQ ID NO: 2192; 2193 and 2200;
probe set #457 consisting of the nucleic acids consisting of SEQ ID NO: 2069; 2070 and 2071;
probe set #458 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2068 and 2103;
probe set #459 consisting of the nucleic acids consisting of SEQ ID NO: 304;
probe set #460 consisting of the nucleic acids consisting of SEQ ID NO: 372 and 373;
probe set #461 consisting of the nucleic acids consisting of SEQ ID NO: 2075; 2076 and 2109;
probe set #462 consisting of the nucleic acids consisting of SEQ ID NO: 2366; 2367 and 2368;
probe set #463 consisting of the nucleic acids consisting of SEQ ID NO: 1948; 1979 and 1980;
probe set #464 consisting of the nucleic acids consisting of SEQ ID NO: 216; 217 and 218;
probe set #465 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2062 and 2063;
probe set #466 consisting of the nucleic acids consisting of SEQ ID NO: 1100; 1101 and 1102;
probe set #467 consisting of the nucleic acids consisting of SEQ ID NO: 1303; 1304 and 1305;
probe set #468 consisting of the nucleic acids consisting of SEQ ID NO: 985;
probe set #469 consisting of the nucleic acids consisting of SEQ ID NO: 2188; 2189 and 2190;
probe set #470 consisting of the nucleic acids consisting of SEQ ID NO: 2069; 2070 and 2071;
probe set #471 consisting of the nucleic acids consisting of SEQ ID NO: 1982; 1983 and 1984;
probe set #472 consisting of the nucleic acids consisting of SEQ ID NO: 1887; 1888 and 1889;
probe set #473 consisting of the nucleic acids consisting of SEQ ID NO: 1995; 1996 and 1997;
probe set #474 consisting of the nucleic acids consisting of SEQ ID NO: 2931;
probe set #475 consisting of the nucleic acids consisting of SEQ ID NO: 865; 866 and 867;
probe set #476 consisting of the nucleic acids consisting of SEQ ID NO: 268; 269 and 270;
probe set #477 consisting of the nucleic acids consisting of SEQ ID NO: 2286; 2287 and 2288;
probe set #478 consisting of the nucleic acids consisting of SEQ ID NO: 1117; 1118 and 1124;
probe set #479 consisting of the nucleic acids consisting of SEQ ID NO: 2059; 2100 and 2101;
probe set #480 consisting of the nucleic acids consisting of SEQ ID NO: 388; 389 and 390;
probe set #481 consisting of the nucleic acids consisting of SEQ ID NO: 2286; 2287 and 2288;
probe set #482 consisting of the nucleic acids consisting of SEQ ID NO: 2055;
probe set #483 consisting of the nucleic acids consisting of SEQ ID NO: 2573; 2574 and 2575;
probe set #484 consisting of the nucleic acids consisting of SEQ ID NO: 2075 and 2076;
probe set #485 consisting of the nucleic acids consisting of SEQ ID NO: 2689; 2690 and 2691;
probe set #486 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2102;
probe set #487 consisting of the nucleic acids consisting of SEQ ID NO: 1388; 1389 and 1390;
probe set #488 consisting of the nucleic acids consisting of SEQ ID NO: 2889; 2890 and 2891;
probe set #489 consisting of the nucleic acids consisting of SEQ ID NO: 1565; 1599 and 1601;
probe set #490 consisting of the nucleic acids consisting of SEQ ID NO: 2157; 2158 and 2159;
probe set #491 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1987;
probe set #492 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2063 and 2068;
probe set #493 consisting of the nucleic acids consisting of SEQ ID NO: 1574; 1575 and 1576;
probe set #494 consisting of the nucleic acids consisting of SEQ ID NO: 743; 744 and 745;
probe set #495 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1962;
probe set #496 consisting of the nucleic acids consisting of SEQ ID NO: 1927; 1947 and 1987;
probe set #497 consisting of the nucleic acids consisting of SEQ ID NO: 2286; 2287 and 2288;
probe set #498 consisting of the nucleic acids consisting of SEQ ID NO: 2286; 2287 and 2288;
probe set #499 consisting of the nucleic acids consisting of SEQ ID NO: 1676; 1677 and 1678;
probe set #500 consisting of the nucleic acids consisting of SEQ ID NO: 1041; 1042 and 1043;
probe set #501 consisting of the nucleic acids consisting of SEQ ID NO: 2375; 2376 and 2377;
probe set #502 consisting of the nucleic acids consisting of SEQ ID NO: 1920 and 1921;
probe set #503 consisting of the nucleic acids consisting of SEQ ID NO: 2061; 2093 and 2107;
probe set #504 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1962;
probe set #505 consisting of the nucleic acids consisting of SEQ ID NO: 2908; 2917 and 2918;
probe set #506 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1921 and 1922;
probe set #507 consisting of the nucleic acids consisting of SEQ ID NO: 1922;
probe set #508 consisting of the nucleic acids consisting of SEQ ID NO: 2489; 2490 and 2491;
probe set #509 consisting of the nucleic acids consisting of SEQ ID NO: 2909; 2910 and 2917;
probe set #510 consisting of the nucleic acids consisting of SEQ ID NO: 725; 726 and 727;
probe set #511 consisting of the nucleic acids consisting of SEQ ID NO: 2304; 2305 and 2308;
probe set #512 consisting of the nucleic acids consisting of SEQ ID NO: 829; 830 and 831;
probe set #513 consisting of the nucleic acids consisting of SEQ ID NO: 2414; 2415 and 2416;
probe set #514 consisting of the nucleic acids consisting of SEQ ID NO: 2003; 2005 and 2006;
probe set #515 consisting of the nucleic acids consisting of SEQ ID NO: 731; 732 and 736;
probe set #516 consisting of the nucleic acids consisting of SEQ ID NO: 1926 and 1962;
probe set #517 consisting of the nucleic acids consisting of SEQ ID NO: 2662; 2663 and 2664;
probe set #518 consisting of the nucleic acids consisting of SEQ ID NO: 1142; 1143 and 1144;
probe set #519 consisting of the nucleic acids consisting of SEQ ID NO: 1296; 1297 and 1298;
probe set #520 consisting of the nucleic acids consisting of SEQ ID NO: 1943; 1948 and 1978;
probe set #521 consisting of the nucleic acids consisting of SEQ ID NO: 2899; 2900 and 2901;
probe set #522 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2065 and 2072;
probe set #523 consisting of the nucleic acids consisting of SEQ ID NO: 982;
probe set #524 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #525 consisting of the nucleic acids consisting of SEQ ID NO: 1655;
probe set #526 consisting of the nucleic acids consisting of SEQ ID NO: 1008; 1009 and 1010;
probe set #527 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #528 consisting of the nucleic acids consisting of SEQ ID NO: 37; 38 and 39;
probe set #529 consisting of the nucleic acids consisting of SEQ ID NO: 2852; 2853 and 2854;
probe set #530 consisting of the nucleic acids consisting of SEQ ID NO: 1721; 1722 and 1723;
probe set #531 consisting of the nucleic acids consisting of SEQ ID NO: 2902; 2903 and 2904;
probe set #532 consisting of the nucleic acids consisting of SEQ ID NO: 1920 and 1921;
probe set #533 consisting of the nucleic acids consisting of SEQ ID NO: 761; 762 and 765;
probe set #534 consisting of the nucleic acids consisting of SEQ ID NO: 2086 and 2087;
probe set #535 consisting of the nucleic acids consisting of SEQ ID NO: 435; 436 and 437;
probe set #536 consisting of the nucleic acids consisting of SEQ ID NO: 1397; 1398 and 1399;
probe set #537 consisting of the nucleic acids consisting of SEQ ID NO: 2808; 2809 and 2810;
probe set #538 consisting of the nucleic acids consisting of SEQ ID NO: 1032; 1033 and 1034;
probe set #539 consisting of the nucleic acids consisting of SEQ ID NO: 1129; 1140 and 1141;
probe set #540 consisting of the nucleic acids consisting of SEQ ID NO: 2517; 2518 and 2519;
probe set #541 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1962;
probe set #542 consisting of the nucleic acids consisting of SEQ ID NO: 1029; 1030 and 1031;
probe set #543 consisting of the nucleic acids consisting of SEQ ID NO: 2296; 2297 and 2298;
probe set #544 consisting of the nucleic acids consisting of SEQ ID NO: 1869; 1870 and 1871;
probe set #545 consisting of the nucleic acids consisting of SEQ ID NO: 985;
probe set #546 consisting of the nucleic acids consisting of SEQ ID NO: 1464; 1465 and 1466;
probe set #547 consisting of the nucleic acids consisting of SEQ ID NO: 1418; 1419 and 1420;
probe set #548 consisting of the nucleic acids consisting of SEQ ID NO: 1916; 1917 and 1918;
probe set #549 consisting of the nucleic acids consisting of SEQ ID NO: 1406; 1407 and 1413;
probe set #550 consisting of the nucleic acids consisting of SEQ ID NO: 35 and 36;
probe set #551 consisting of the nucleic acids consisting of SEQ ID NO: 2254; 2255 and 2256;
probe set #552 consisting of the nucleic acids consisting of SEQ ID NO: 1920 and 1921;
probe set #553 consisting of the nucleic acids consisting of SEQ ID NO: 1737; 1738 and 1739;
probe set #554 consisting of the nucleic acids consisting of SEQ ID NO: 573; 643 and 644;
probe set #555 consisting of the nucleic acids consisting of SEQ ID NO: 2304; 2305 and 2307;
probe set #556 consisting of the nucleic acids consisting of SEQ ID NO: 2530; 2531 and 2532;
probe set #557 consisting of the nucleic acids consisting of SEQ ID NO: 2628; 2629 and 2630;
probe set #558 consisting of the nucleic acids consisting of SEQ ID NO: 1223; 1224 and 1225;
probe set #559 consisting of the nucleic acids consisting of SEQ ID NO: 1210; 1211 and 1212;
probe set #560 consisting of the nucleic acids consisting of SEQ ID NO: 1839; 1840 and 1841;
probe set #561 consisting of the nucleic acids consisting of SEQ ID NO: 2561; 2562 and 2563;
probe set #562 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #563 consisting of the nucleic acids consisting of SEQ ID NO: 446; 453 and 454;
probe set #564 consisting of the nucleic acids consisting of SEQ ID NO: 321; 323 and 322;
probe set #565 consisting of the nucleic acids consisting of SEQ ID NO: 2423; 2424 and 2425;
probe set #566 consisting of the nucleic acids consisting of SEQ ID NO: 2216 and 2217;
probe set #567 consisting of the nucleic acids consisting of SEQ ID NO: 2658; 2670 and 2708;
probe set #568 consisting of the nucleic acids consisting of SEQ ID NO: 1366; 1367 and 1368;
probe set #569 consisting of the nucleic acids consisting of SEQ ID NO: 1920 and 1921;
probe set #570 consisting of the nucleic acids consisting of SEQ ID NO: 1926; 1961 and 1962;
probe set #571 consisting of the nucleic acids consisting of SEQ ID NO: 1050; 1051 and 1052;
probe set #572 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1932 and 1962;
probe set #573 consisting of the nucleic acids consisting of SEQ ID NO: 2100; 2101 and 2105;
probe set #574 consisting of the nucleic acids consisting of SEQ ID NO: 1151; 1152 and 1153;
probe set #575 consisting of the nucleic acids consisting of SEQ ID NO: 2717; 2718 and 2719;
probe set #576 consisting of the nucleic acids consisting of SEQ ID NO: 1382; 1383 and 1384;
probe set #577 consisting of the nucleic acids consisting of SEQ ID NO: 2061;
probe set #578 consisting of the nucleic acids consisting of SEQ ID NO: 1211; 1212 and 1226;
probe set #579 consisting of the nucleic acids consisting of SEQ ID NO: 1227 and 1228;
probe set #580 consisting of the nucleic acids consisting of SEQ ID NO: 1665; 1666 and 1667;
probe set #581 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #582 consisting of the nucleic acids consisting of SEQ ID NO: 2580; 2581 and 2582;
probe set #583 consisting of the nucleic acids consisting of SEQ ID NO: 2662; 2663 and 2664;
probe set #584 consisting of the nucleic acids consisting of SEQ ID NO: 1017; 1018 and 1019;
probe set #585 consisting of the nucleic acids consisting of SEQ ID NO: 573; 642 and 644;
probe set #586 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #587 consisting of the nucleic acids consisting of SEQ ID NO: 222; 223 and 224;
probe set #588 consisting of the nucleic acids consisting of SEQ ID NO: 1948;
probe set #589 consisting of the nucleic acids consisting of SEQ ID NO: 749; 750 and 751;
probe set #590 consisting of the nucleic acids consisting of SEQ ID NO: 1565; 1598 and 1599;
probe set #591 consisting of the nucleic acids consisting of SEQ ID NO: 2911; 2912 and 2913;
probe set #592 consisting of the nucleic acids consisting of SEQ ID NO: 2668; 2669 and 2709;
probe set #593 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2676 and 2759;
probe set #594 consisting of the nucleic acids consisting of SEQ ID NO: 1934;
probe set #595 consisting of the nucleic acids consisting of SEQ ID NO: 1932; 1935 and 1978;
probe set #596 consisting of the nucleic acids consisting of SEQ ID NO: 840; 841 and 845;
probe set #597 consisting of the nucleic acids consisting of SEQ ID NO: 1749; 1750 and 1751;
probe set #598 consisting of the nucleic acids consisting of SEQ ID NO: 2049; 2050 and 2051;
probe set #599 consisting of the nucleic acids consisting of SEQ ID NO: 752; 753 and 754;
probe set #600 consisting of the nucleic acids consisting of SEQ ID NO: 541; 542 and 543;
probe set #601 consisting of the nucleic acids consisting of SEQ ID NO: 1106; 1107 and 1108;
probe set #602 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2102;
probe set #603 consisting of the nucleic acids consisting of SEQ ID NO: 1965; 1966 and 1967;
probe set #604 consisting of the nucleic acids consisting of SEQ ID NO: 2417; 2418 and 2419;
probe set #605 consisting of the nucleic acids consisting of SEQ ID NO: 519; 520 and 521;
probe set #606 consisting of the nucleic acids consisting of SEQ ID NO: 971;
probe set #607 consisting of the nucleic acids consisting of SEQ ID NO: 884 and 888;
probe set #608 consisting of the nucleic acids consisting of SEQ ID NO: 40; 41 and 42;
probe set #609 consisting of the nucleic acids consisting of SEQ ID NO: 24; 25 and 26;
probe set #610 consisting of the nucleic acids consisting of SEQ ID NO: 1182; 1183 and 1184;
probe set #611 consisting of the nucleic acids consisting of SEQ ID NO: 2658; 2676 and 2759;
probe set #612 consisting of the nucleic acids consisting of SEQ ID NO: 2765; 2766 and 2767;
probe set #613 consisting of the nucleic acids consisting of SEQ ID NO: 410; 411 and 412;
probe set #614 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #615 consisting of the nucleic acids consisting of SEQ ID NO: 1782; 1783 and 1784;
probe set #616 consisting of the nucleic acids consisting of SEQ ID NO: 1926 and 1962;
probe set #617 consisting of the nucleic acids consisting of SEQ ID NO: 975; 976 and 977;
probe set #618 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2092;
probe set #619 consisting of the nucleic acids consisting of SEQ ID NO: 429; 430 and 438;
probe set #620 consisting of the nucleic acids consisting of SEQ ID NO: 1072; 1073 and 1074;
probe set #621 consisting of the nucleic acids consisting of SEQ ID NO: 309; 311 and 310;
probe set #622 consisting of the nucleic acids consisting of SEQ ID NO: 2321; 2322 and 2323;
probe set #623 consisting of the nucleic acids consisting of SEQ ID NO: 1540;
probe set #624 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2102;
probe set #625 consisting of the nucleic acids consisting of SEQ ID NO: 733; 734 and 735;
probe set #626 consisting of the nucleic acids consisting of SEQ ID NO: 99; 100 and 101;
probe set #627 consisting of the nucleic acids consisting of SEQ ID NO: 1394;
probe set #628 consisting of the nucleic acids consisting of SEQ ID NO: 2780; 2781 and 2782;
probe set #629 consisting of the nucleic acids consisting of SEQ ID NO: 1372; 1373 and 1374;
probe set #630 consisting of the nucleic acids consisting of SEQ ID NO: 2679; 2680 and 2681;
probe set #631 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2708 and 2754;
probe set #632 consisting of the nucleic acids consisting of SEQ ID NO: 1965; 1966 and 1967;
probe set #633 consisting of the nucleic acids consisting of SEQ ID NO: 2795;
probe set #634 consisting of the nucleic acids consisting of SEQ ID NO: 2002;
probe set #635 consisting of the nucleic acids consisting of SEQ ID NO: 68; 69 and 70;
probe set #636 consisting of the nucleic acids consisting of SEQ ID NO: 1020; 1021 and 1022;
probe set #637 consisting of the nucleic acids consisting of SEQ ID NO: 148; 149 and 150;
probe set #638 consisting of the nucleic acids consisting of SEQ ID NO: 1307; 1308 and 1309;
probe set #639 consisting of the nucleic acids consisting of SEQ ID NO: 1944; 1945 and 1946;
probe set #640 consisting of the nucleic acids consisting of SEQ ID NO: 446; 454 and 455;
probe set #641 consisting of the nucleic acids consisting of SEQ ID NO: 1767; 1768 and 1769;
probe set #642 consisting of the nucleic acids consisting of SEQ ID NO: 1971; 1972 and 1987;
probe set #643 consisting of the nucleic acids consisting of SEQ ID NO: 2795;
probe set #644 consisting of the nucleic acids consisting of SEQ ID NO: 899; 900 and 901;
probe set #645 consisting of the nucleic acids consisting of SEQ ID NO: 1962; 1998 and 1999;
probe set #646 consisting of the nucleic acids consisting of SEQ ID NO: 2041; 2042 and 2043;
probe set #647 consisting of the nucleic acids consisting of SEQ ID NO: 1927; 1955 and 1978;
probe set #648 consisting of the nucleic acids consisting of SEQ ID NO: 1990;
probe set #649 consisting of the nucleic acids consisting of SEQ ID NO: 1403; 1404 and 1408;
probe set #650 consisting of the nucleic acids consisting of SEQ ID NO: 1968; 1969 and 1970;
probe set #651 consisting of the nucleic acids consisting of SEQ ID NO: 2209; 2210 and 2211;
probe set #652 consisting of the nucleic acids consisting of SEQ ID NO: 1770; 1771 and 1772;
probe set #653 consisting of the nucleic acids consisting of SEQ ID NO: 1382; 1383 and 1384;
probe set #654 consisting of the nucleic acids consisting of SEQ ID NO: 1927; 1932 and 1987;
probe set #655 consisting of the nucleic acids consisting of SEQ ID NO: 2248;
probe set #656 consisting of the nucleic acids consisting of SEQ ID NO: 2501; 2502 and 2503;
probe set #657 consisting of the nucleic acids consisting of SEQ ID NO: 1133; 1134 and 1135;
probe set #658 consisting of the nucleic acids consisting of SEQ ID NO: 1668; 1669 and 1670;
probe set #659 consisting of the nucleic acids consisting of SEQ ID NO: 2925; 2926 and 2927;
probe set #660 consisting of the nucleic acids consisting of SEQ ID NO: 201; 202 and 203;
probe set #661 consisting of the nucleic acids consisting of SEQ ID NO: 1602; 1603 and 1604;
probe set #662 consisting of the nucleic acids consisting of SEQ ID NO: 1936; 1937 and 1938;
probe set #663 consisting of the nucleic acids consisting of SEQ ID NO: 2504; 2512 and 2543;
probe set #664 consisting of the nucleic acids consisting of SEQ ID NO: 1119; 1120 and 1121;
probe set #665 consisting of the nucleic acids consisting of SEQ ID NO: 1400; 1401 and 1402;
probe set #666 consisting of the nucleic acids consisting of SEQ ID NO: 2700; 2701 and 2702;
probe set #667 consisting of the nucleic acids consisting of SEQ ID NO: 2811; 2812 and 2813;
probe set #668 consisting of the nucleic acids consisting of SEQ ID NO: 1955 and 1964;
probe set #669 consisting of the nucleic acids consisting of SEQ ID NO: 672; 673 and 674;
probe set #670 consisting of the nucleic acids consisting of SEQ ID NO: 582; 583 and 584;
probe set #671 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #672 consisting of the nucleic acids consisting of SEQ ID NO: 2755; 2756 and 2757;
probe set #673 consisting of the nucleic acids consisting of SEQ ID NO: 2659 and 2746;
probe set #674 consisting of the nucleic acids consisting of SEQ ID NO: 2035; 2036 and 2037;
probe set #675 consisting of the nucleic acids consisting of SEQ ID NO: 2662; 2663 and 2664;
probe set #676 consisting of the nucleic acids consisting of SEQ ID NO: 2771; 2772 and 2773;
probe set #677 consisting of the nucleic acids consisting of SEQ ID NO: 2317; 2318 and 2319;
probe set #678 consisting of the nucleic acids consisting of SEQ ID NO: 456; 457 and 458;
probe set #679 consisting of the nucleic acids consisting of SEQ ID NO: 2539; 2540 and 2541;
probe set #680 consisting of the nucleic acids consisting of SEQ ID NO: 2582; 2583 and 2584;
probe set #681 consisting of the nucleic acids consisting of SEQ ID NO: 868; 1117 and 1118;
probe set #682 consisting of the nucleic acids consisting of SEQ ID NO: 2801;
probe set #683 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2707 and 2709;
probe set #684 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #685 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #686 consisting of the nucleic acids consisting of SEQ ID NO: 1791; 1792 and 1793;
probe set #687 consisting of the nucleic acids consisting of SEQ ID NO: 633; 634 and 635;
probe set #688 consisting of the nucleic acids consisting of SEQ ID NO: 1351; 1352 and 1353;
probe set #689 consisting of the nucleic acids consisting of SEQ ID NO: 934; 935 and 941;
probe set #690 consisting of the nucleic acids consisting of SEQ ID NO: 938; 939 and 940;
probe set #691 consisting of the nucleic acids consisting of SEQ ID NO: 1009; 1023 and 1024;
probe set #692 consisting of the nucleic acids consisting of SEQ ID NO: 2314; 2315 and 2316;
probe set #693 consisting of the nucleic acids consisting of SEQ ID NO: 2704; 2705 and 2706;
probe set #694 consisting of the nucleic acids consisting of SEQ ID NO: 2341; 2342 and 2343;
probe set #695 consisting of the nucleic acids consisting of SEQ ID NO: 1797; 1798 and 1799;
probe set #696 consisting of the nucleic acids consisting of SEQ ID NO: 1767; 1768 and 1769;
probe set #697 consisting of the nucleic acids consisting of SEQ ID NO: 1467 and 1468;
probe set #698 consisting of the nucleic acids consisting of SEQ ID NO: 1770; 1771 and 1772;
probe set #699 consisting of the nucleic acids consisting of SEQ ID NO: 2035; 2036 and 2037;
probe set #700 consisting of the nucleic acids consisting of SEQ ID NO: 37; 38 and 39;
probe set #701 consisting of the nucleic acids consisting of SEQ ID NO: 678; 679 and 680;
probe set #702 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #703 consisting of the nucleic acids consisting of SEQ ID NO: 2242; 2252 and 2271;
probe set #704 consisting of the nucleic acids consisting of SEQ ID NO: 2417; 2418 and 2419;
probe set #705 consisting of the nucleic acids consisting of SEQ ID NO: 2356; 2357 and 2358;
probe set #706 consisting of the nucleic acids consisting of SEQ ID NO: 1541; 1542 and 1543;
probe set #707 consisting of the nucleic acids consisting of SEQ ID NO: 2245; 2246 and 2247;
probe set #708 consisting of the nucleic acids consisting of SEQ ID NO: 2194; 2198 and 2199;
probe set #709 consisting of the nucleic acids consisting of SEQ ID NO: 2498; 2499 and 2500;
probe set #710 consisting of the nucleic acids consisting of SEQ ID NO: 287; 289 and 288;
probe set #711 consisting of the nucleic acids consisting of SEQ ID NO: 2671; 2672 and 2708;
probe set #712 consisting of the nucleic acids consisting of SEQ ID NO: 2130; 2131 and 2132;
probe set #713 consisting of the nucleic acids consisting of SEQ ID NO: 448; 449 and 450;
probe set #714 consisting of the nucleic acids consisting of SEQ ID NO: 413; 414 and 415;
probe set #715 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2150 and 2151;
probe set #716 consisting of the nucleic acids consisting of SEQ ID NO: 2875; 2876 and 2877;
probe set #717 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #718 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2092;
probe set #719 consisting of the nucleic acids consisting of SEQ ID NO: 983; 984 and 985;
probe set #720 consisting of the nucleic acids consisting of SEQ ID NO: 1276; 1277 and 1285;
probe set #721 consisting of the nucleic acids consisting of SEQ ID NO: 985;
probe set #722 consisting of the nucleic acids consisting of SEQ ID NO: 2631; 2632 and 2633;
probe set #723 consisting of the nucleic acids consisting of SEQ ID NO: 207; 208 and 209;
probe set #724 consisting of the nucleic acids consisting of SEQ ID NO: 999; 1000 and 1001;
probe set #725 consisting of the nucleic acids consisting of SEQ ID NO: 521; 527 and 528;
probe set #726 consisting of the nucleic acids consisting of SEQ ID NO: 111; 112 and 113;
probe set #727 consisting of the nucleic acids consisting of SEQ ID NO: 1400; 1401 and 1402;
probe set #728 consisting of the nucleic acids consisting of SEQ ID NO: 1339; 1340 and 1341;
probe set #729 consisting of the nucleic acids consisting of SEQ ID NO: 912; 913 and 914;
probe set #730 consisting of the nucleic acids consisting of SEQ ID NO: 1574; 1575 and 1576;
probe set #731 consisting of the nucleic acids consisting of SEQ ID NO: 573; 614 and 642;
probe set #732 consisting of the nucleic acids consisting of SEQ ID NO: 1761; 1762 and 1763;
probe set #733 consisting of the nucleic acids consisting of SEQ ID NO: 2713; 2714 and 2715;
probe set #734 consisting of the nucleic acids consisting of SEQ ID NO: 589; 590 and 591;
probe set #735 consisting of the nucleic acids consisting of SEQ ID NO: 53; 54 and 55;
probe set #736 consisting of the nucleic acids consisting of SEQ ID NO: 2768; 2769 and 2770;
probe set #737 consisting of the nucleic acids consisting of SEQ ID NO: 264; 271 and 272;
probe set #738 consisting of the nucleic acids consisting of SEQ ID NO: 2321; 2322 and 2323;
probe set #739 consisting of the nucleic acids consisting of SEQ ID NO: 2683; 2684 and 2685;
probe set #740 consisting of the nucleic acids consisting of SEQ ID NO: 2160; 2161 and 2162;
probe set #741 consisting of the nucleic acids consisting of SEQ ID NO: 1097; 1098 and 1099;
probe set #742 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2065 and 2098;
probe set #743 consisting of the nucleic acids consisting of SEQ ID NO: 263; 264 and 271;
probe set #744 consisting of the nucleic acids consisting of SEQ ID NO: 1278; 1279 and 1280;
probe set #745 consisting of the nucleic acids consisting of SEQ ID NO: 2596; 2597 and 2598;
probe set #746 consisting of the nucleic acids consisting of SEQ ID NO: 1964; 1988 and 1989;
probe set #747 consisting of the nucleic acids consisting of SEQ ID NO: 2547;
probe set #748 consisting of the nucleic acids consisting of SEQ ID NO: 1605; 1606 and 1607;
probe set #749 consisting of the nucleic acids consisting of SEQ ID NO: 204; 205 and 206;
probe set #750 consisting of the nucleic acids consisting of SEQ ID NO: 2245; 2246 and 2247;
probe set #751 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2703 and 2709;
probe set #752 consisting of the nucleic acids consisting of SEQ ID NO: 1406; 1407 and 1413;
probe set #753 consisting of the nucleic acids consisting of SEQ ID NO: 1435;
probe set #754 consisting of the nucleic acids consisting of SEQ ID NO: 766; 767 and 768;
probe set #755 consisting of the nucleic acids consisting of SEQ ID NO: 1381;
probe set #756 consisting of the nucleic acids consisting of SEQ ID NO: 2222; 2223 and 2224;
probe set #757 consisting of the nucleic acids consisting of SEQ ID NO: 1238;
probe set #758 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #759 consisting of the nucleic acids consisting of SEQ ID NO: 1981;
probe set #760 consisting of the nucleic acids consisting of SEQ ID NO: 746; 747 and 748;
probe set #761 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2707 and 2709;
probe set #762 consisting of the nucleic acids consisting of SEQ ID NO: 1927; 1943 and 1978;
probe set #763 consisting of the nucleic acids consisting of SEQ ID NO: 2232; 2233 and 2234;
probe set #764 consisting of the nucleic acids consisting of SEQ ID NO: 2052; 2053 and 2054;
probe set #765 consisting of the nucleic acids consisting of SEQ ID NO: 1713; 1714 and 1715;
probe set #766 consisting of the nucleic acids consisting of SEQ ID NO: 602 and 603;
probe set #767 consisting of the nucleic acids consisting of SEQ ID NO: 702; 703 and 704;
probe set #768 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #769 consisting of the nucleic acids consisting of SEQ ID NO: 1943; 1955 and 1978;
probe set #770 consisting of the nucleic acids consisting of SEQ ID NO: 2378; 2379 and 2380;
probe set #771 consisting of the nucleic acids consisting of SEQ ID NO: 702; 703 and 704;
probe set #772 consisting of the nucleic acids consisting of SEQ ID NO: 2073; 2074 and 2109;
probe set #773 consisting of the nucleic acids consisting of SEQ ID NO: 2936; 2937 and 2938;
probe set #774 consisting of the nucleic acids consisting of SEQ ID NO: 2280; 2281 and 2282;
probe set #775 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #776 consisting of the nucleic acids consisting of SEQ ID NO: 1231; 1232 and 1233;
probe set #777 consisting of the nucleic acids consisting of SEQ ID NO: 1764; 1765 and 1766;
probe set #778 consisting of the nucleic acids consisting of SEQ ID NO: 391; 392 and 393;
probe set #779 consisting of the nucleic acids consisting of SEQ ID NO: 1931; 1962 and 1999;
probe set #780 consisting of the nucleic acids consisting of SEQ ID NO: 2282; 2289 and 2305;
probe set #781 consisting of the nucleic acids consisting of SEQ ID NO: 582; 583 and 584;
probe set #782 consisting of the nucleic acids consisting of SEQ ID NO: 1220; 1221 and 1222;
probe set #783 consisting of the nucleic acids consisting of SEQ ID NO: 1935;
probe set #784 consisting of the nucleic acids consisting of SEQ ID NO: 1718; 1719 and 1720;
probe set #785 consisting of the nucleic acids consisting of SEQ ID NO: 1737; 1738 and 1739;
probe set #786 consisting of the nucleic acids consisting of SEQ ID NO: 2908; 2909 and 2917;
probe set #787 consisting of the nucleic acids consisting of SEQ ID NO: 1957;
probe set #788 consisting of the nucleic acids consisting of SEQ ID NO: 2622; 2623 and 2624;
probe set #789 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #790 consisting of the nucleic acids consisting of SEQ ID NO: 2192; 2193 and 2200;
probe set #791 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #792 consisting of the nucleic acids consisting of SEQ ID NO: 1296; 1487 and 1488;
probe set #793 consisting of the nucleic acids consisting of SEQ ID NO: 947; 948 and 949;
probe set #794 consisting of the nucleic acids consisting of SEQ ID NO: 2617; 2618 and 2619;
probe set #795 consisting of the nucleic acids consisting of SEQ ID NO: 2362;
probe set #796 consisting of the nucleic acids consisting of SEQ ID NO: 1129; 1139 and 1140;
probe set #797 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2703 and 2709;
probe set #798 consisting of the nucleic acids consisting of SEQ ID NO: 419; 420 and 421;
probe set #799 consisting of the nucleic acids consisting of SEQ ID NO: 23; 29 and 30;
probe set #800 consisting of the nucleic acids consisting of SEQ ID NO: 1122;
probe set #801 consisting of the nucleic acids consisting of SEQ ID NO: 1423; 1447 and 1448;
probe set #802 consisting of the nucleic acids consisting of SEQ ID NO: 2710; 2711 and 2712;
probe set #803 consisting of the nucleic acids consisting of SEQ ID NO: 675; 676 and 677;
probe set #804 consisting of the nucleic acids consisting of SEQ ID NO: 2458; 2461 and 2462;
probe set #805 consisting of the nucleic acids consisting of SEQ ID NO: 1831; 1832 and 1833;
probe set #806 consisting of the nucleic acids consisting of SEQ ID NO: 618; 619 and 620;
probe set #807 consisting of the nucleic acids consisting of SEQ ID NO: 983; 984 and 985;
probe set #808 consisting of the nucleic acids consisting of SEQ ID NO: 2000 and 2001;
probe set #809 consisting of the nucleic acids consisting of SEQ ID NO: 2625; 2626 and 2627;
probe set #810 consisting of the nucleic acids consisting of SEQ ID NO: 714; 715 and 716;
probe set #811 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2758;
probe set #812 consisting of the nucleic acids consisting of SEQ ID NO: 448; 449 and 450;
probe set #813 consisting of the nucleic acids consisting of SEQ ID NO: 1986;
probe set #814 consisting of the nucleic acids consisting of SEQ ID NO: 2699;
probe set #815 consisting of the nucleic acids consisting of SEQ ID NO: 2726; 2727 and 2728;
probe set #816 consisting of the nucleic acids consisting of SEQ ID NO: 2145; 2146 and 2147;
probe set #817 consisting of the nucleic acids consisting of SEQ ID NO: 2437; 2459 and 2460;
probe set #818 consisting of the nucleic acids consisting of SEQ ID NO: 2743; 2744 and 2745;
probe set #819 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2703 and 2709;
probe set #820 consisting of the nucleic acids consisting of SEQ ID NO: 592; 593 and 594;
probe set #821 consisting of the nucleic acids consisting of SEQ ID NO: 476; 477 and 478;
probe set #822 consisting of the nucleic acids consisting of SEQ ID NO: 1011; 1012 and 1013;
probe set #823 consisting of the nucleic acids consisting of SEQ ID NO: 1571; 1572 and 1573;
probe set #824 consisting of the nucleic acids consisting of SEQ ID NO: 1345; 1346 and 1347;
probe set #825 consisting of the nucleic acids consisting of SEQ ID NO: 2242; 2252 and 2259;
probe set #826 consisting of the nucleic acids consisting of SEQ ID NO: 661 and 662;
probe set #827 consisting of the nucleic acids consisting of SEQ ID NO: 1608; 1609 and 1610;
probe set #828 consisting of the nucleic acids consisting of SEQ ID NO: 2170; 2171 and 2172;
probe set #829 consisting of the nucleic acids consisting of SEQ ID NO: 2855; 2856 and 2859;
probe set #830 consisting of the nucleic acids consisting of SEQ ID NO: 1785; 1786 and 1787;
probe set #831 consisting of the nucleic acids consisting of SEQ ID NO: 1231; 1232 and 1233;
probe set #832 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #833 consisting of the nucleic acids consisting of SEQ ID NO: 766; 767 and 768;
probe set #834 consisting of the nucleic acids consisting of SEQ ID NO: 518; 522 and 523;
probe set #835 consisting of the nucleic acids consisting of SEQ ID NO: 2876; 2877 and 2878;
probe set #836 consisting of the nucleic acids consisting of SEQ ID NO: 1351; 1352 and 1353;
probe set #837 consisting of the nucleic acids consisting of SEQ ID NO: 630; 631 and 632;
probe set #838 consisting of the nucleic acids consisting of SEQ ID NO: 1577; 1578 and 1579;
probe set #839 consisting of the nucleic acids consisting of SEQ ID NO: 275; 276 and 277;
probe set #840 consisting of the nucleic acids consisting of SEQ ID NO: 2637; 2638 and 2639;
probe set #841 consisting of the nucleic acids consisting of SEQ ID NO: 1806; 1821 and 1822;
probe set #842 consisting of the nucleic acids consisting of SEQ ID NO: 233; 249 and 250;
probe set #843 consisting of the nucleic acids consisting of SEQ ID NO: 769; 770 and 771;
probe set #844 consisting of the nucleic acids consisting of SEQ ID NO: 996; 997 and 998;
probe set #845 consisting of the nucleic acids consisting of SEQ ID NO: 927; 928 and 929;
probe set #846 consisting of the nucleic acids consisting of SEQ ID NO: 399; 400 and 401;
probe set #847 consisting of the nucleic acids consisting of SEQ ID NO: 219; 220 and 221;
probe set #848 consisting of the nucleic acids consisting of SEQ ID NO: 2347; 2348 and 2349;
probe set #849 consisting of the nucleic acids consisting of SEQ ID NO: 71; 72 and 73;
probe set #850 consisting of the nucleic acids consisting of SEQ ID NO: 35 and 36;
probe set #851 consisting of the nucleic acids consisting of SEQ ID NO: 2704; 2705 and 2706;
probe set #852 consisting of the nucleic acids consisting of SEQ ID NO: 2263;
probe set #853 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #854 consisting of the nucleic acids consisting of SEQ ID NO: 13; 14 and 16;
probe set #855 consisting of the nucleic acids consisting of SEQ ID NO: 1779; 1780 and 1781;
probe set #856 consisting of the nucleic acids consisting of SEQ ID NO: 2309 and 2310;
probe set #857 consisting of the nucleic acids consisting of SEQ ID NO: 1884; 1885 and 1886;
probe set #858 consisting of the nucleic acids consisting of SEQ ID NO: 1964; 1988 and 1989;
probe set #859 consisting of the nucleic acids consisting of SEQ ID NO: 1354; 1355 and 1356;
probe set #860 consisting of the nucleic acids consisting of SEQ ID NO: 2660; 2672 and 2708;
probe set #861 consisting of the nucleic acids consisting of SEQ ID NO: 1281; 1282 and 1283;
probe set #862 consisting of the nucleic acids consisting of SEQ ID NO: 1332; 1333 and 1334;
probe set #863 consisting of the nucleic acids consisting of SEQ ID NO: 1090; 1091 and 1092;
probe set #864 consisting of the nucleic acids consisting of SEQ ID NO: 2099;
probe set #865 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2705 and 2761;
probe set #866 consisting of the nucleic acids consisting of SEQ ID NO: 2747; 2748 and 2753;
probe set #867 consisting of the nucleic acids consisting of SEQ ID NO: 1834 and 1835;
probe set #868 consisting of the nucleic acids consisting of SEQ ID NO: 2010; 2011 and 2012;
probe set #869 consisting of the nucleic acids consisting of SEQ ID NO: 2658; 2747 and 2753;
probe set #870 consisting of the nucleic acids consisting of SEQ ID NO: 442; 443 and 444;
probe set #871 consisting of the nucleic acids consisting of SEQ ID NO: 2274; 2275 and 2276;
probe set #872 consisting of the nucleic acids consisting of SEQ ID NO: 1926 and 1962;
probe set #873 consisting of the nucleic acids consisting of SEQ ID NO: 2833; 2834 and 2835;
probe set #874 consisting of the nucleic acids consisting of SEQ ID NO: 2686; 2687 and 2688;
probe set #875 consisting of the nucleic acids consisting of SEQ ID NO: 2300; 2301 and 2306;
probe set #876 consisting of the nucleic acids consisting of SEQ ID NO: 719; 720 and 721;
probe set #877 consisting of the nucleic acids consisting of SEQ ID NO: 13; 14 and 16;
probe set #878 consisting of the nucleic acids consisting of SEQ ID NO: 702; 705 and 709;
probe set #879 consisting of the nucleic acids consisting of SEQ ID NO: 1351; 1352 and 1353;
probe set #880 consisting of the nucleic acids consisting of SEQ ID NO: 889; 890 and 891;
probe set #881 consisting of the nucleic acids consisting of SEQ ID NO: 164; 165 and 166;
probe set #882 consisting of the nucleic acids consisting of SEQ ID NO: 908; 909 and 910;
probe set #883 consisting of the nucleic acids consisting of SEQ ID NO: 2720; 2721 and 2722;
probe set #884 consisting of the nucleic acids consisting of SEQ ID NO: 2486; 2487 and 2488;
probe set #885 consisting of the nucleic acids consisting of SEQ ID NO: 871 and 872;
probe set #886 consisting of the nucleic acids consisting of SEQ ID NO: 105; 106 and 107;
probe set #887 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #888 consisting of the nucleic acids consisting of SEQ ID NO: 651;
probe set #889 consisting of the nucleic acids consisting of SEQ ID NO: 1611; 1612 and 1613;
probe set #890 consisting of the nucleic acids consisting of SEQ ID NO: 2165; 2166 and 2167;
probe set #891 consisting of the nucleic acids consisting of SEQ ID NO: 875 and 880;
probe set #892 consisting of the nucleic acids consisting of SEQ ID NO: 2089;
probe set #893 consisting of the nucleic acids consisting of SEQ ID NO: 2299;
probe set #894 consisting of the nucleic acids consisting of SEQ ID NO: 1154; 1155 and 1156;
probe set #895 consisting of the nucleic acids consisting of SEQ ID NO: 2052; 2053 and 2054;
probe set #896 consisting of the nucleic acids consisting of SEQ ID NO: 2660; 2694 and 2695;
probe set #897 consisting of the nucleic acids consisting of SEQ ID NO: 2431 and 2432;
probe set #898 consisting of the nucleic acids consisting of SEQ ID NO: 761; 762 and 764;
probe set #899 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2077 and 2092;
probe set #900 consisting of the nucleic acids consisting of SEQ ID NO: 1767; 1768 and 1769;
probe set #901 consisting of the nucleic acids consisting of SEQ ID NO: 902;
probe set #902 consisting of the nucleic acids consisting of SEQ ID NO: 702; 705 and 709;
probe set #903 consisting of the nucleic acids consisting of SEQ ID NO: 933; 936 and 937;
probe set #904 consisting of the nucleic acids consisting of SEQ ID NO: 762; 765 and 773;
probe set #905 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2097;
probe set #906 consisting of the nucleic acids consisting of SEQ ID NO: 2145; 2146 and 2147;
probe set #907 consisting of the nucleic acids consisting of SEQ ID NO: 687; 688 and 689;
probe set #908 consisting of the nucleic acids consisting of SEQ ID NO: 83; 84 and 85;
probe set #909 consisting of the nucleic acids consisting of SEQ ID NO: 2318; 2319 and 2320;
probe set #910 consisting of the nucleic acids consisting of SEQ ID NO: 2580; 2581 and 2582;
probe set #911 consisting of the nucleic acids consisting of SEQ ID NO: 2879; 2880 and 2882;
probe set #912 consisting of the nucleic acids consisting of SEQ ID NO: 2551; 2552 and 2553;
probe set #913 consisting of the nucleic acids consisting of SEQ ID NO: 2734; 2735 and 2736;
probe set #914 consisting of the nucleic acids consisting of SEQ ID NO: 2268; 2269 and 2270;
probe set #915 consisting of the nucleic acids consisting of SEQ ID NO: 934; 935 and 941;
probe set #916 consisting of the nucleic acids consisting of SEQ ID NO: 2838;
probe set #917 consisting of the nucleic acids consisting of SEQ ID NO: 1412 and 1414;
probe set #918 consisting of the nucleic acids consisting of SEQ ID NO: 1273; 1274 and 1275;
probe set #919 consisting of the nucleic acids consisting of SEQ ID NO: 65; 66 and 67;
probe set #920 consisting of the nucleic acids consisting of SEQ ID NO: 2052; 2056 and 2057;
probe set #921 consisting of the nucleic acids consisting of SEQ ID NO: 1727; 1728 and 1729;
probe set #922 consisting of the nucleic acids consisting of SEQ ID NO: 1357; 1358 and 1359;
probe set #923 consisting of the nucleic acids consisting of SEQ ID NO: 2737; 2738 and 2739;
probe set #924 consisting of the nucleic acids consisting of SEQ ID NO: 2879; 2880 and 2881;
probe set #925 consisting of the nucleic acids consisting of SEQ ID NO: 2932;
probe set #926 consisting of the nucleic acids consisting of SEQ ID NO: 93; 94 and 95;
probe set #927 consisting of the nucleic acids consisting of SEQ ID NO: 2133;
probe set #928 consisting of the nucleic acids consisting of SEQ ID NO: 574; 587 and 588;
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probe set #930 consisting of the nucleic acids consisting of SEQ ID NO: 2914; 2915 and 2916;
probe set #931 consisting of the nucleic acids consisting of SEQ ID NO: 1496; 1498 and 1506;
probe set #932 consisting of the nucleic acids consisting of SEQ ID NO: 1731; 1732 and 1733;
probe set #933 consisting of the nucleic acids consisting of SEQ ID NO: 2292; 2293 and 2294;
probe set #934 consisting of the nucleic acids consisting of SEQ ID NO: 1461; 1462 and 1463;
probe set #935 consisting of the nucleic acids consisting of SEQ ID NO: 2646; 2647 and 2648;
probe set #936 consisting of the nucleic acids consisting of SEQ ID NO: 2788; 2789 and 2790;
probe set #937 consisting of the nucleic acids consisting of SEQ ID NO: 2428; 2429 and 2430;
probe set #938 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 886;
probe set #939 consisting of the nucleic acids consisting of SEQ ID NO: 416; 417 and 418;
probe set #940 consisting of the nucleic acids consisting of SEQ ID NO: 402; 403 and 404;
probe set #941 consisting of the nucleic acids consisting of SEQ ID NO: 56; 57 and 58;
probe set #942 consisting of the nucleic acids consisting of SEQ ID NO: 473; 474 and 475;
probe set #943 consisting of the nucleic acids consisting of SEQ ID NO: 663; 664 and 665;
probe set #944 consisting of the nucleic acids consisting of SEQ ID NO: 1876; 1877 and 1878;
probe set #945 consisting of the nucleic acids consisting of SEQ ID NO: 1716 and 1717;
probe set #946 consisting of the nucleic acids consisting of SEQ ID NO: 2233; 2234 and 2238;
probe set #947 consisting of the nucleic acids consisting of SEQ ID NO: 1813; 1814 and 1815;
probe set #948 consisting of the nucleic acids consisting of SEQ ID NO: 740; 741 and 742;
probe set #949 consisting of the nucleic acids consisting of SEQ ID NO: 1028;
probe set #950 consisting of the nucleic acids consisting of SEQ ID NO: 2889; 2890 and 2891;
probe set #951 consisting of the nucleic acids consisting of SEQ ID NO: 2780; 2781 and 2782;
probe set #952 consisting of the nucleic acids consisting of SEQ ID NO: 482; 483 and 484;
probe set #953 consisting of the nucleic acids consisting of SEQ ID NO: 1855; 1856 and 1857;
probe set #954 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 886;
probe set #955 consisting of the nucleic acids consisting of SEQ ID NO: 1407; 1412 and 1413;
probe set #956 consisting of the nucleic acids consisting of SEQ ID NO: 595;
probe set #957 consisting of the nucleic acids consisting of SEQ ID NO: 2585; 2586 and 2587;
probe set #958 consisting of the nucleic acids consisting of SEQ ID NO: 908; 909 and 910;
probe set #959 consisting of the nucleic acids consisting of SEQ ID NO: 659; 660 and 661;
probe set #960 consisting of the nucleic acids consisting of SEQ ID NO: 2218; 2219 and 2220;
probe set #961 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2672 and 2708;
probe set #962 consisting of the nucleic acids consisting of SEQ ID NO: 621; 622 and 623;
probe set #963 consisting of the nucleic acids consisting of SEQ ID NO: 213; 214 and 215;
probe set #964 consisting of the nucleic acids consisting of SEQ ID NO: 1851; 1853 and 1854;
probe set #965 consisting of the nucleic acids consisting of SEQ ID NO: 2420; 2421 and 2422;
probe set #966 consisting of the nucleic acids consisting of SEQ ID NO: 1909;
probe set #967 consisting of the nucleic acids consisting of SEQ ID NO: 485; 486 and 487;
probe set #968 consisting of the nucleic acids consisting of SEQ ID NO: 2249; 2250 and 2251;
probe set #969 consisting of the nucleic acids consisting of SEQ ID NO: 1400; 1401 and 1402;
probe set #970 consisting of the nucleic acids consisting of SEQ ID NO: 2073; 2074 and 2109;
probe set #971 consisting of the nucleic acids consisting of SEQ ID NO: 518; 522 and 523;
probe set #972 consisting of the nucleic acids consisting of SEQ ID NO: 702; 703 and 704;
probe set #973 consisting of the nucleic acids consisting of SEQ ID NO: 1794; 1795 and 1796;
probe set #974 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #975 consisting of the nucleic acids consisting of SEQ ID NO: 1173;
probe set #976 consisting of the nucleic acids consisting of SEQ ID NO: 2277; 2278 and 2279;
probe set #977 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2672;
probe set #978 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #979 consisting of the nucleic acids consisting of SEQ ID NO: 2704; 2705 and 2706;
probe set #980 consisting of the nucleic acids consisting of SEQ ID NO: 2544; 2545 and 2546;
probe set #981 consisting of the nucleic acids consisting of SEQ ID NO: 233; 249 and 250;
probe set #982 consisting of the nucleic acids consisting of SEQ ID NO: 2589; 2591 and 2592;
probe set #983 consisting of the nucleic acids consisting of SEQ ID NO: 684; 685 and 686;
probe set #984 consisting of the nucleic acids consisting of SEQ ID NO: 2124; 2125 and 2126;
probe set #985 consisting of the nucleic acids consisting of SEQ ID NO: 240; 241 and 242;
probe set #986 consisting of the nucleic acids consisting of SEQ ID NO: 1624; 1625 and 1626;
probe set #987 consisting of the nucleic acids consisting of SEQ ID NO: 2474; 2475 and 2476;
probe set #988 consisting of the nucleic acids consisting of SEQ ID NO: 1652; 1653 and 1654;
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probe set #990 consisting of the nucleic acids consisting of SEQ ID NO: 902 and 911;
probe set #991 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #992 consisting of the nucleic acids consisting of SEQ ID NO: 2729; 2730 and 2731;
probe set #993 consisting of the nucleic acids consisting of SEQ ID NO: 1577; 1578 and 1579;
probe set #994 consisting of the nucleic acids consisting of SEQ ID NO: 2397; 2398 and 2399;
probe set #995 consisting of the nucleic acids consisting of SEQ ID NO: 1421; 1422 and 1423;
probe set #996 consisting of the nucleic acids consisting of SEQ ID NO: 2080; 2081 and 2082;
probe set #997 consisting of the nucleic acids consisting of SEQ ID NO: 941; 942 and 943;
probe set #998 consisting of the nucleic acids consisting of SEQ ID NO: 1407; 1412 and 1413;
probe set #999 consisting of the nucleic acids consisting of SEQ ID NO: 610; 611 and 612;
probe set #1000 consisting of the nucleic acids consisting of SEQ ID NO: 780; 781 and 782;
probe set #1001 consisting of the nucleic acids consisting of SEQ ID NO: 2849; 2850 and 2851;
probe set #1002 consisting of the nucleic acids consisting of SEQ ID NO: 2318; 2319 and 2324;
probe set #1003 consisting of the nucleic acids consisting of SEQ ID NO: 2065; 2068 and 2098;
probe set #1004 consisting of the nucleic acids consisting of SEQ ID NO: 1905; 1906 and 1907;
probe set #1005 consisting of the nucleic acids consisting of SEQ ID NO: 1617; 1618 and 1619;
probe set #1006 consisting of the nucleic acids consisting of SEQ ID NO: 2118 and 2119;
probe set #1007 consisting of the nucleic acids consisting of SEQ ID NO: 1391; 1392 and 1393;
probe set #1008 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2065 and 2098;
probe set #1009 consisting of the nucleic acids consisting of SEQ ID NO: 2673; 2674 and 2675;
probe set #1010 consisting of the nucleic acids consisting of SEQ ID NO: 2879; 2880 and 2881;
probe set #1011 consisting of the nucleic acids consisting of SEQ ID NO: 405; 406 and 407;
probe set #1012 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1013 consisting of the nucleic acids consisting of SEQ ID NO: 1106; 1107 and 1108;
probe set #1014 consisting of the nucleic acids consisting of SEQ ID NO: 2466;
probe set #1015 consisting of the nucleic acids consisting of SEQ ID NO: 964;
probe set #1016 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2156;
probe set #1017 consisting of the nucleic acids consisting of SEQ ID NO: 2000 and 2001;
probe set #1018 consisting of the nucleic acids consisting of SEQ ID NO: 83; 84 and 85;
probe set #1019 consisting of the nucleic acids consisting of SEQ ID NO: 2182; 2183 and 2184;
probe set #1020 consisting of the nucleic acids consisting of SEQ ID NO: 2127; 2128 and 2129;
probe set #1021 consisting of the nucleic acids consisting of SEQ ID NO: 646;
probe set #1022 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #1023 consisting of the nucleic acids consisting of SEQ ID NO: 589; 590 and 591;
probe set #1024 consisting of the nucleic acids consisting of SEQ ID NO: 930 and 931;
probe set #1025 consisting of the nucleic acids consisting of SEQ ID NO: 2290; 2291 and 2310;
probe set #1026 consisting of the nucleic acids consisting of SEQ ID NO: 237; 238 and 239;
probe set #1027 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1028 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2150 and 2151;
probe set #1029 consisting of the nucleic acids consisting of SEQ ID NO: 2514; 2515 and 2516;
probe set #1030 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1031 consisting of the nucleic acids consisting of SEQ ID NO: 133; 134 and 135;
probe set #1032 consisting of the nucleic acids consisting of SEQ ID NO: 1342; 1343 and 1344;
probe set #1033 consisting of the nucleic acids consisting of SEQ ID NO: 2329; 2335 and 2336;
probe set #1034 consisting of the nucleic acids consisting of SEQ ID NO: 2433; 2434 and 2435;
probe set #1035 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #1036 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2092;
probe set #1037 consisting of the nucleic acids consisting of SEQ ID NO: 875; 876 and 880;
probe set #1038 consisting of the nucleic acids consisting of SEQ ID NO: 1035;
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probe set #1040 consisting of the nucleic acids consisting of SEQ ID NO: 596; 597 and 598;
probe set #1041 consisting of the nucleic acids consisting of SEQ ID NO: 233; 249 and 250;
probe set #1042 consisting of the nucleic acids consisting of SEQ ID NO: 544 and 545;
probe set #1043 consisting of the nucleic acids consisting of SEQ ID NO: 2073; 2074 and 2110;
probe set #1044 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1045 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2708 and 2754;
probe set #1046 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2149 and 2150;
probe set #1047 consisting of the nucleic acids consisting of SEQ ID NO: 251; 252 and 253;
probe set #1048 consisting of the nucleic acids consisting of SEQ ID NO: 2617; 2618 and 2619;
probe set #1049 consisting of the nucleic acids consisting of SEQ ID NO: 233; 249 and 250;
probe set #1050 consisting of the nucleic acids consisting of SEQ ID NO: 1923; 1924 and 1925;
probe set #1051 consisting of the nucleic acids consisting of SEQ ID NO: 2446 and 2447;
probe set #1052 consisting of the nucleic acids consisting of SEQ ID NO: 1360; 1361 and 1362;
probe set #1053 consisting of the nucleic acids consisting of SEQ ID NO: 2141; 2142 and 2143;
probe set #1054 consisting of the nucleic acids consisting of SEQ ID NO: 2283; 2284 and 2285;
probe set #1055 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #1056 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2149 and 2150;
probe set #1057 consisting of the nucleic acids consisting of SEQ ID NO: 2242; 2252 and 2253;
probe set #1058 consisting of the nucleic acids consisting of SEQ ID NO: 2749; 2750 and 2751;
probe set #1059 consisting of the nucleic acids consisting of SEQ ID NO: 1934;
probe set #1060 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1061 consisting of the nucleic acids consisting of SEQ ID NO: 2061;
probe set #1062 consisting of the nucleic acids consisting of SEQ ID NO: 1025; 1026 and 1027;
probe set #1063 consisting of the nucleic acids consisting of SEQ ID NO: 960; 961 and 962;
probe set #1064 consisting of the nucleic acids consisting of SEQ ID NO: 2652; 2653 and 2654;
probe set #1065 consisting of the nucleic acids consisting of SEQ ID NO: 2144;
probe set #1066 consisting of the nucleic acids consisting of SEQ ID NO: 1627; 1628 and 1629;
probe set #1067 consisting of the nucleic acids consisting of SEQ ID NO: 921; 922 and 923;
probe set #1068 consisting of the nucleic acids consisting of SEQ ID NO: 1956;
probe set #1069 consisting of the nucleic acids consisting of SEQ ID NO: 1014; 1015 and 1016;
probe set #1070 consisting of the nucleic acids consisting of SEQ ID NO: 1800; 1801 and 1802;
probe set #1071 consisting of the nucleic acids consisting of SEQ ID NO: 445;
probe set #1072 consisting of the nucleic acids consisting of SEQ ID NO: 12; 13 and 20;
probe set #1073 consisting of the nucleic acids consisting of SEQ ID NO: 43; 44 and 45;
probe set #1074 consisting of the nucleic acids consisting of SEQ ID NO: 576; 577 and 578;
probe set #1075 consisting of the nucleic acids consisting of SEQ ID NO: 2329; 2334 and 2335;
probe set #1076 consisting of the nucleic acids consisting of SEQ ID NO: 1219;
probe set #1077 consisting of the nucleic acids consisting of SEQ ID NO: 225; 226 and 227;
probe set #1078 consisting of the nucleic acids consisting of SEQ ID NO: 2384; 2385 and 2386;
probe set #1079 consisting of the nucleic acids consisting of SEQ ID NO: 2579 and 2582;
probe set #1080 consisting of the nucleic acids consisting of SEQ ID NO: 2580; 2581 and 2582;
probe set #1081 consisting of the nucleic acids consisting of SEQ ID NO: 231; 232 and 233;
probe set #1082 consisting of the nucleic acids consisting of SEQ ID NO: 2329; 2334 and 2335;
probe set #1083 consisting of the nucleic acids consisting of SEQ ID NO: 1624; 1625 and 1626;
probe set #1084 consisting of the nucleic acids consisting of SEQ ID NO: 607; 608 and 609;
probe set #1085 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #1086 consisting of the nucleic acids consisting of SEQ ID NO: 1277;
probe set #1087 consisting of the nucleic acids consisting of SEQ ID NO: 978; 979 and 980;
probe set #1088 consisting of the nucleic acids consisting of SEQ ID NO: 2130; 2131 and 2134;
probe set #1089 consisting of the nucleic acids consisting of SEQ ID NO: 2257; 2258 and 2271;
probe set #1090 consisting of the nucleic acids consisting of SEQ ID NO: 2670; 2676 and 2759;
probe set #1091 consisting of the nucleic acids consisting of SEQ ID NO: 1825; 1826 and 1827;
probe set #1092 consisting of the nucleic acids consisting of SEQ ID NO: 2661 and 2748;
probe set #1093 consisting of the nucleic acids consisting of SEQ ID NO: 2823; 2824 and 2825;
probe set #1094 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2150 and 2151;
probe set #1095 consisting of the nucleic acids consisting of SEQ ID NO: 479; 480 and 481;
probe set #1096 consisting of the nucleic acids consisting of SEQ ID NO: 2065; 2068 and 2098;
probe set #1097 consisting of the nucleic acids consisting of SEQ ID NO: 2411; 2412 and 2426;
probe set #1098 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2150 and 2151;
probe set #1099 consisting of the nucleic acids consisting of SEQ ID NO: 1455; 1456 and 1457;
probe set #1100 consisting of the nucleic acids consisting of SEQ ID NO: 1630 and 1631;
probe set #1101 consisting of the nucleic acids consisting of SEQ ID NO: 2243; 2272 and 2273;
probe set #1102 consisting of the nucleic acids consisting of SEQ ID NO: 2839; 2840 and 2849;
probe set #1103 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1104 consisting of the nucleic acids consisting of SEQ ID NO: 1627; 1628 and 1629;
probe set #1105 consisting of the nucleic acids consisting of SEQ ID NO: 2458; 2461 and 2462;
probe set #1106 consisting of the nucleic acids consisting of SEQ ID NO: 2295;
probe set #1107 consisting of the nucleic acids consisting of SEQ ID NO: 40; 41 and 42;
probe set #1108 consisting of the nucleic acids consisting of SEQ ID NO: 1923; 1924 and 1925;
probe set #1109 consisting of the nucleic acids consisting of SEQ ID NO: 2078 and 2079;
probe set #1110 consisting of the nucleic acids consisting of SEQ ID NO: 908; 909 and 910;
probe set #1111 consisting of the nucleic acids consisting of SEQ ID NO: 21; 22 and 31;
probe set #1112 consisting of the nucleic acids consisting of SEQ ID NO: 2145; 2146 and 2147;
probe set #1113 consisting of the nucleic acids consisting of SEQ ID NO: 2317; 2318 and 2319;
probe set #1114 consisting of the nucleic acids consisting of SEQ ID NO: 1709;
probe set #1115 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1116 consisting of the nucleic acids consisting of SEQ ID NO: 1949; 1950 and 1951;
probe set #1117 consisting of the nucleic acids consisting of SEQ ID NO: 693; 694 and 695;
probe set #1118 consisting of the nucleic acids consisting of SEQ ID NO: 2289; 2303 and 2305;
probe set #1119 consisting of the nucleic acids consisting of SEQ ID NO: 1296; 1297 and 1298;
probe set #1120 consisting of the nucleic acids consisting of SEQ ID NO: 32; 33 and 34;
probe set #1121 consisting of the nucleic acids consisting of SEQ ID NO: 90; 91 and 92;
probe set #1122 consisting of the nucleic acids consisting of SEQ ID NO: 885; 886 and 887;
probe set #1123 consisting of the nucleic acids consisting of SEQ ID NO: 2; 10 and 11;
probe set #1124 consisting of the nucleic acids consisting of SEQ ID NO: 2634; 2635 and 2636;
probe set #1125 consisting of the nucleic acids consisting of SEQ ID NO: 1624; 1625 and 1626;
probe set #1126 consisting of the nucleic acids consisting of SEQ ID NO: 2495; 2496 and 2497;
probe set #1127 consisting of the nucleic acids consisting of SEQ ID NO: 2696; 2697 and 2698;
probe set #1128 consisting of the nucleic acids consisting of SEQ ID NO: 504; 505 and 506;
probe set #1129 consisting of the nucleic acids consisting of SEQ ID NO: 568; 569 and 570;
probe set #1130 consisting of the nucleic acids consisting of SEQ ID NO: 2672; 2752 and 2758;
probe set #1131 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1132 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1133 consisting of the nucleic acids consisting of SEQ ID NO: 2839; 2840 and 2849;
probe set #1134 consisting of the nucleic acids consisting of SEQ ID NO: 192; 193 and 194;
probe set #1135 consisting of the nucleic acids consisting of SEQ ID NO: 1936; 1937 and 1938;
probe set #1136 consisting of the nucleic acids consisting of SEQ ID NO: 1002; 1003 and 1004;
probe set #1137 consisting of the nucleic acids consisting of SEQ ID NO: 2325; 2326 and 2327;
probe set #1138 consisting of the nucleic acids consisting of SEQ ID NO: 1385; 1386 and 1387;
probe set #1139 consisting of the nucleic acids consisting of SEQ ID NO: 2353; 2354 and 2355;
probe set #1140 consisting of the nucleic acids consisting of SEQ ID NO: 2408; 2409 and 2410;
probe set #1141 consisting of the nucleic acids consisting of SEQ ID NO: 237; 238 and 239;
probe set #1142 consisting of the nucleic acids consisting of SEQ ID NO: 2093;
probe set #1143 consisting of the nucleic acids consisting of SEQ ID NO: 1656; 1657 and 1658;
probe set #1144 consisting of the nucleic acids consisting of SEQ ID NO: 2427;
probe set #1145 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #1146 consisting of the nucleic acids consisting of SEQ ID NO: 2446; 2457 and 2458;
probe set #1147 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1148 consisting of the nucleic acids consisting of SEQ ID NO: 289; 294 and 293;
probe set #1149 consisting of the nucleic acids consisting of SEQ ID NO: 1429; 1430; 1431 and 1432
probe set #1150 consisting of the nucleic acids consisting of SEQ ID NO: 2665; 2666 and 2667;
probe set #1151 consisting of the nucleic acids consisting of SEQ ID NO: 2185; 2186 and 2187;
probe set #1152 consisting of the nucleic acids consisting of SEQ ID NO: 2118; 2119 and 2120;
probe set #1153 consisting of the nucleic acids consisting of SEQ ID NO: 102; 103 and 104;
probe set #1154 consisting of the nucleic acids consisting of SEQ ID NO: 2905; 2906 and 2907;
probe set #1155 consisting of the nucleic acids consisting of SEQ ID NO: 2692 and 2693;
probe set #1156 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1157 consisting of the nucleic acids consisting of SEQ ID NO: 2740; 2741 and 2742;
probe set #1158 consisting of the nucleic acids consisting of SEQ ID NO: 1991; 1992 and 1993;
probe set #1159 consisting of the nucleic acids consisting of SEQ ID NO: 1348; 1349 and 1350;
probe set #1160 consisting of the nucleic acids consisting of SEQ ID NO: 574; 575 and 587;
probe set #1161 consisting of the nucleic acids consisting of SEQ ID NO: 2805; 2806 and 2807;
probe set #1162 consisting of the nucleic acids consisting of SEQ ID NO: 571; 572 and 573;
probe set #1163 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2709;
probe set #1164 consisting of the nucleic acids consisting of SEQ ID NO: 2003; 2004 and 2008;
probe set #1165 consisting of the nucleic acids consisting of SEQ ID NO: 2659; 2660 and 2758;
probe set #1166 consisting of the nucleic acids consisting of SEQ ID NO: 2796 and 2797;
probe set #1167 consisting of the nucleic acids consisting of SEQ ID NO: 624; 625 and 626;
probe set #1168 consisting of the nucleic acids consisting of SEQ ID NO: 2135; 2136 and 2137;
probe set #1169 consisting of the nucleic acids consisting of SEQ ID NO: 59; 60 and 61;
probe set #1170 consisting of the nucleic acids consisting of SEQ ID NO: 549; 550 and 551;
probe set #1171 consisting of the nucleic acids consisting of SEQ ID NO: 856; 857 and 858;
probe set #1172 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 888;
probe set #1173 consisting of the nucleic acids consisting of SEQ ID NO: 2148; 2150 and 2151;
probe set #1174 consisting of the nucleic acids consisting of SEQ ID NO: 2436; 2437 and 2460;
probe set #1175 consisting of the nucleic acids consisting of SEQ ID NO: 1803; 1804 and 1816;
probe set #1176 consisting of the nucleic acids consisting of SEQ ID NO: 884 and 888;
probe set #1177 consisting of the nucleic acids consisting of SEQ ID NO: 2141; 2142 and 2143;
probe set #1178 consisting of the nucleic acids consisting of SEQ ID NO: 921; 922 and 923;
probe set #1179 consisting of the nucleic acids consisting of SEQ ID NO: 1922;
probe set #1180 consisting of the nucleic acids consisting of SEQ ID NO: 1286;
probe set #1181 consisting of the nucleic acids consisting of SEQ ID NO: 2012; 2016 and 2017;
probe set #1182 consisting of the nucleic acids consisting of SEQ ID NO: 2003; 2004 and 2007;
probe set #1183 consisting of the nucleic acids consisting of SEQ ID NO: 1756 and 1757;
probe set #1184 consisting of the nucleic acids consisting of SEQ ID NO: 408;
probe set #1185 consisting of the nucleic acids consisting of SEQ ID NO: 83; 84 and 85;
probe set #1186 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1187 consisting of the nucleic acids consisting of SEQ ID NO: 2150; 2151 and 2152;
probe set #1188 consisting of the nucleic acids consisting of SEQ ID NO: 1851; 1852 and 1854;
probe set #1189 consisting of the nucleic acids consisting of SEQ ID NO: 546; 547 and 548;
probe set #1190 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1191 consisting of the nucleic acids consisting of SEQ ID NO: 2138; 2139 and 2140;
probe set #1192 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #1193 consisting of the nucleic acids consisting of SEQ ID NO: 1740; 1741 and 1742;
probe set #1194 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1195 consisting of the nucleic acids consisting of SEQ ID NO: 1975; 1976 and 1977;
probe set #1196 consisting of the nucleic acids consisting of SEQ ID NO: 146; 147 and 150;
probe set #1197 consisting of the nucleic acids consisting of SEQ ID NO: 1452; 1453 and 1454;
probe set #1198 consisting of the nucleic acids consisting of SEQ ID NO: 692; 693 and 695;
probe set #1199 consisting of the nucleic acids consisting of SEQ ID NO: 2895;
probe set #1200 consisting of the nucleic acids consisting of SEQ ID NO: 993; 994 and 995;
probe set #1201 consisting of the nucleic acids consisting of SEQ ID NO: 2359; 2360 and 2361;
probe set #1202 consisting of the nucleic acids consisting of SEQ ID NO: 2826; 2827 and 2828;
probe set #1203 consisting of the nucleic acids consisting of SEQ ID NO: 2872; 2873 and 2878;
probe set #1204 consisting of the nucleic acids consisting of SEQ ID NO: 2567; 2568 and 2569;
probe set #1205 consisting of the nucleic acids consisting of SEQ ID NO: 114; 115 and 116;
probe set #1206 consisting of the nucleic acids consisting of SEQ ID NO: 2554; 2555 and 2556;
probe set #1207 consisting of the nucleic acids consisting of SEQ ID NO: 117; 118 and 119;
probe set #1208 consisting of the nucleic acids consisting of SEQ ID NO: 2507; 2508 and 2509;
probe set #1209 consisting of the nucleic acids consisting of SEQ ID NO: 1923; 1924 and 1925;
probe set #1210 consisting of the nucleic acids consisting of SEQ ID NO: 702; 717 and 718;
probe set #1211 consisting of the nucleic acids consisting of SEQ ID NO: 142; 143 and 144;
probe set #1212 consisting of the nucleic acids consisting of SEQ ID NO: 2242; 2252 and 2267;
probe set #1213 consisting of the nucleic acids consisting of SEQ ID NO: 2611; 2612 and 2613;
probe set #1214 consisting of the nucleic acids consisting of SEQ ID NO: 1881; 1882 and 1883;
probe set #1215 consisting of the nucleic acids consisting of SEQ ID NO: 1862; 1863 and 1864;
probe set #1216 consisting of the nucleic acids consisting of SEQ ID NO: 470; 471 and 472;
probe set #1217 consisting of the nucleic acids consisting of SEQ ID NO: 524; 525 and 526;
probe set #1218 consisting of the nucleic acids consisting of SEQ ID NO: 656; 657 and 658;
probe set #1219 consisting of the nucleic acids consisting of SEQ ID NO: 2444; 2445 and 2446;
probe set #1220 consisting of the nucleic acids consisting of SEQ ID NO: 50; 51 and 52;
probe set #1221 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2092;
probe set #1222 consisting of the nucleic acids consisting of SEQ ID NO: 2820; 2821 and 2822;
probe set #1223 consisting of the nucleic acids consisting of SEQ ID NO: 2046; 2047 and 2048;
probe set #1224 consisting of the nucleic acids consisting of SEQ ID NO: 1806; 1807 and 1808;
probe set #1225 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2089 and 2092;
probe set #1226 consisting of the nucleic acids consisting of SEQ ID NO: 1415; 1416 and 1417;
probe set #1227 consisting of the nucleic acids consisting of SEQ ID NO: 2433; 2434 and 2435; and
probe set #1228 consisting of the nucleic acids consisting of SEQ ID NO: 2433; 2434 and 2435.
6. The combination according to claim 5, comprising 1640 polynucleotide probe sets,
said 1640 polynucleotide probe sets comprising probe set #1 to probe set #1228, and
probe set #1229 consisting of the nucleic acids consisting of SEQ ID NO: 690 and 691;
probe set #1230 consisting of the nucleic acids consisting of SEQ ID NO: 2094; 2095 and 2096;
probe set #1231 consisting of the nucleic acids consisting of SEQ ID NO: 532; 533 and 534;
probe set #1232 consisting of the nucleic acids consisting of SEQ ID NO: 2570; 2571 and 2572;
probe set #1233 consisting of the nucleic acids consisting of SEQ ID NO: 516; 517 and 518;
probe set #1234 consisting of the nucleic acids consisting of SEQ ID NO: 1449; 1450 and 1451;
probe set #1235 consisting of the nucleic acids consisting of SEQ ID NO: 950; 951 and 952;
probe set #1236 consisting of the nucleic acids consisting of SEQ ID NO: 1749; 1751 and 1752;
probe set #1237 consisting of the nucleic acids consisting of SEQ ID NO: 1614; 1615 and 1616;
probe set #1238 consisting of the nucleic acids consisting of SEQ ID NO: 1400; 1401 and 1402;
probe set #1239 consisting of the nucleic acids consisting of SEQ ID NO: 2477; 2478 and 2479;
probe set #1240 consisting of the nucleic acids consisting of SEQ ID NO: 1964;
probe set #1241 consisting of the nucleic acids consisting of SEQ ID NO: 2607; 2608 and 2609;
probe set #1242 consisting of the nucleic acids consisting of SEQ ID NO: 544; 545 and 544;
probe set #1243 consisting of the nucleic acids consisting of SEQ ID NO: 301; 303 and 302;
probe set #1244 consisting of the nucleic acids consisting of SEQ ID NO: 918; 919 and 920;
probe set #1245 consisting of the nucleic acids consisting of SEQ ID NO: 1923; 1924 and 1925;
probe set #1246 consisting of the nucleic acids consisting of SEQ ID NO: 1620; 1632 and 1633;
probe set #1247 consisting of the nucleic acids consisting of SEQ ID NO: 1464; 1465 and 1466;
probe set #1248 consisting of the nucleic acids consisting of SEQ ID NO: 184; 185 and 186;
probe set #1249 consisting of the nucleic acids consisting of SEQ ID NO: 681; 682 and 683;
probe set #1250 consisting of the nucleic acids consisting of SEQ ID NO: 2607; 2608 and 2609;
probe set #1251 consisting of the nucleic acids consisting of SEQ ID NO: 2384; 2385 and 2387;
probe set #1252 consisting of the nucleic acids consisting of SEQ ID NO: 2564; 2565 and 2566;
probe set #1253 consisting of the nucleic acids consisting of SEQ ID NO: 1634; 1635 and 1636;
probe set #1254 consisting of the nucleic acids consisting of SEQ ID NO: 1875;
probe set #1255 consisting of the nucleic acids consisting of SEQ ID NO: 2833; 2834 and 2835;
probe set #1256 consisting of the nucleic acids consisting of SEQ ID NO: 1753; 1754 and 1755;
probe set #1257 consisting of the nucleic acids consisting of SEQ ID NO: 2830; 2836 and 2837;
probe set #1258 consisting of the nucleic acids consisting of SEQ ID NO: 2869; 2870 and 2871;
probe set #1259 consisting of the nucleic acids consisting of SEQ ID NO: 1710; 1711 and 1712;
probe set #1260 consisting of the nucleic acids consisting of SEQ ID NO: 592; 593 and 594;
probe set #1261 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1262 consisting of the nucleic acids consisting of SEQ ID NO: 357; 359 and 358;
probe set #1263 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2607 and 2610;
probe set #1264 consisting of the nucleic acids consisting of SEQ ID NO: 2403;
probe set #1265 consisting of the nucleic acids consisting of SEQ ID NO: 432; 433 and 434;
probe set #1266 consisting of the nucleic acids consisting of SEQ ID NO: 2264; 2265 and 2266;
probe set #1267 consisting of the nucleic acids consisting of SEQ ID NO: 956; 957 and 958;
probe set #1268 consisting of the nucleic acids consisting of SEQ ID NO: 758; 759 and 760;
probe set #1269 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1270 consisting of the nucleic acids consisting of SEQ ID NO: 1409; 1410 and 1411;
probe set #1271 consisting of the nucleic acids consisting of SEQ ID NO: 1920; 1933 and 1999;
probe set #1272 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1273 consisting of the nucleic acids consisting of SEQ ID NO: 21; 22 and 23;
probe set #1274 consisting of the nucleic acids consisting of SEQ ID NO: 2841; 2842 and 2843;
probe set #1275 consisting of the nucleic acids consisting of SEQ ID NO: 2063; 2065 and 2068;
probe set #1276 consisting of the nucleic acids consisting of SEQ ID NO: 1458; 1459 and 1460;
probe set #1277 consisting of the nucleic acids consisting of SEQ ID NO: 2019; 2020 and 2021;
probe set #1278 consisting of the nucleic acids consisting of SEQ ID NO: 706; 707 and 708;
probe set #1279 consisting of the nucleic acids consisting of SEQ ID NO: 1859; 1860 and 1861;
probe set #1280 consisting of the nucleic acids consisting of SEQ ID NO: 636; 637 and 638;
probe set #1281 consisting of the nucleic acids consisting of SEQ ID NO: 2388; 2389 and 2390;
probe set #1282 consisting of the nucleic acids consisting of SEQ ID NO: 385; 386 and 387;
probe set #1283 consisting of the nucleic acids consisting of SEQ ID NO: 777; 778 and 779;
probe set #1284 consisting of the nucleic acids consisting of SEQ ID NO: 1936; 1937 and 1938;
probe set #1285 consisting of the nucleic acids consisting of SEQ ID NO: 2094; 2095 and 2096;
probe set #1286 consisting of the nucleic acids consisting of SEQ ID NO: 1749; 1750 and 1752;
probe set #1287 consisting of the nucleic acids consisting of SEQ ID NO: 21; 22 and 31;
probe set #1288 consisting of the nucleic acids consisting of SEQ ID NO: 1366; 1367 and 1380;
probe set #1289 consisting of the nucleic acids consisting of SEQ ID NO: 1701; 1702 and 1703;
probe set #1290 consisting of the nucleic acids consisting of SEQ ID NO: 1936; 1937 and 1938;
probe set #1291 consisting of the nucleic acids consisting of SEQ ID NO: 2013; 2014 and 2015;
probe set #1292 consisting of the nucleic acids consisting of SEQ ID NO: 1913; 1914 and 1915;
probe set #1293 consisting of the nucleic acids consisting of SEQ ID NO: 1336; 1337 and 1338;
probe set #1294 consisting of the nucleic acids consisting of SEQ ID NO: 2060; 2072 and 2092;
probe set #1295 consisting of the nucleic acids consisting of SEQ ID NO: 184; 187 and 188;
probe set #1296 consisting of the nucleic acids consisting of SEQ ID NO: 1702; 1703 and 1704;
probe set #1297 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2607 and 2610;
probe set #1298 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 886;
probe set #1299 consisting of the nucleic acids consisting of SEQ ID NO: 853; 854 and 855;
probe set #1300 consisting of the nucleic acids consisting of SEQ ID NO: 2072; 2089 and 2092;
probe set #1301 consisting of the nucleic acids consisting of SEQ ID NO: 645;
probe set #1302 consisting of the nucleic acids consisting of SEQ ID NO: 231; 232 and 233;
probe set #1303 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1304 consisting of the nucleic acids consisting of SEQ ID NO: 2896; 2897 and 2898;
probe set #1305 consisting of the nucleic acids consisting of SEQ ID NO: 579; 587 and 646;
probe set #1306 consisting of the nucleic acids consisting of SEQ ID NO: 2922; 2923 and 2924;
probe set #1307 consisting of the nucleic acids consisting of SEQ ID NO: 2593; 2594 and 2595;
probe set #1308 consisting of the nucleic acids consisting of SEQ ID NO: 2012 and 2018;
probe set #1309 consisting of the nucleic acids consisting of SEQ ID NO: 2857 and 2858;
probe set #1310 consisting of the nucleic acids consisting of SEQ ID NO: 1855; 1857 and 1858;
probe set #1311 consisting of the nucleic acids consisting of SEQ ID NO: 648; 649 and 650;
probe set #1312 consisting of the nucleic acids consisting of SEQ ID NO: 987; 988 and 989;
probe set #1313 consisting of the nucleic acids consisting of SEQ ID NO: 2003; 2007 and 2009;
probe set #1314 consisting of the nucleic acids consisting of SEQ ID NO: 702; 710 and 717;
probe set #1315 consisting of the nucleic acids consisting of SEQ ID NO: 1484; 1485 and 1486;
probe set #1316 consisting of the nucleic acids consisting of SEQ ID NO: 574; 587 and 647;
probe set #1317 consisting of the nucleic acids consisting of SEQ ID NO: 12; 13 and 20;
probe set #1318 consisting of the nucleic acids consisting of SEQ ID NO: 1868;
probe set #1319 consisting of the nucleic acids consisting of SEQ ID NO: 1157;
probe set #1320 consisting of the nucleic acids consisting of SEQ ID NO: 1758; 1759 and 1760;
probe set #1321 consisting of the nucleic acids consisting of SEQ ID NO: 933; 934 and 935;
probe set #1322 consisting of the nucleic acids consisting of SEQ ID NO: 1372; 1373 and 1379;
probe set #1323 consisting of the nucleic acids consisting of SEQ ID NO: 1378;
probe set #1324 consisting of the nucleic acids consisting of SEQ ID NO: 1627; 1628 and 1629;
probe set #1325 consisting of the nucleic acids consisting of SEQ ID NO: 21; 22 and 23;
probe set #1326 consisting of the nucleic acids consisting of SEQ ID NO: 2012; 2016 and 2022;
probe set #1327 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 888;
probe set #1328 consisting of the nucleic acids consisting of SEQ ID NO: 47; 48 and 49;
probe set #1329 consisting of the nucleic acids consisting of SEQ ID NO: 2396;
probe set #1330 consisting of the nucleic acids consisting of SEQ ID NO: 2814; 2815 and 2816;
probe set #1331 consisting of the nucleic acids consisting of SEQ ID NO: 237; 238 and 239;
probe set #1332 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1333 consisting of the nucleic acids consisting of SEQ ID NO: 2709;
probe set #1334 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2607 and 2610;
probe set #1335 consisting of the nucleic acids consisting of SEQ ID NO: 1375; 1376 and 1377;
probe set #1336 consisting of the nucleic acids consisting of SEQ ID NO: 17; 18 and 19;
probe set #1337 consisting of the nucleic acids consisting of SEQ ID NO: 397;
probe set #1338 consisting of the nucleic acids consisting of SEQ ID NO: 921; 922 and 923;
probe set #1339 consisting of the nucleic acids consisting of SEQ ID NO: 250; 256 and 257;
probe set #1340 consisting of the nucleic acids consisting of SEQ ID NO: 1501; 1502 and 1503;
probe set #1341 consisting of the nucleic acids consisting of SEQ ID NO: 385; 386 and 387;
probe set #1342 consisting of the nucleic acids consisting of SEQ ID NO: 639; 640 and 641;
probe set #1343 consisting of the nucleic acids consisting of SEQ ID NO: 1836; 1837 and 1838;
probe set #1344 consisting of the nucleic acids consisting of SEQ ID NO: 62; 63 and 64;
probe set #1345 consisting of the nucleic acids consisting of SEQ ID NO: 2242; 2243 and 2244;
probe set #1346 consisting of the nucleic acids consisting of SEQ ID NO: 1044; 1045 and 1046;
probe set #1347 consisting of the nucleic acids consisting of SEQ ID NO: 1615; 1616 and 1620;
probe set #1348 consisting of the nucleic acids consisting of SEQ ID NO: 2724; 2732 and 2733;
probe set #1349 consisting of the nucleic acids consisting of SEQ ID NO: 87; 88 and 89;
probe set #1350 consisting of the nucleic acids consisting of SEQ ID NO: 706; 707 and 708;
probe set #1351 consisting of the nucleic acids consisting of SEQ ID NO: 881; 882 and 883;
probe set #1352 consisting of the nucleic acids consisting of SEQ ID NO: 2029; 2030 and 2031;
probe set #1353 consisting of the nucleic acids consisting of SEQ ID NO: 2448; 2449 and 2450;
probe set #1354 consisting of the nucleic acids consisting of SEQ ID NO: 46;
probe set #1355 consisting of the nucleic acids consisting of SEQ ID NO: 574; 575 and 613;
probe set #1356 consisting of the nucleic acids consisting of SEQ ID NO: 394; 395 and 396;
probe set #1357 consisting of the nucleic acids consisting of SEQ ID NO: 2844; 2845 and 2846;
probe set #1358 consisting of the nucleic acids consisting of SEQ ID NO: 2165; 2168 and 2169;
probe set #1359 consisting of the nucleic acids consisting of SEQ ID NO: 2111; 2112 and 2113;
probe set #1360 consisting of the nucleic acids consisting of SEQ ID NO: 2404; 2405 and 2407;
probe set #1361 consisting of the nucleic acids consisting of SEQ ID NO: 2463; 2464 and 2465;
probe set #1362 consisting of the nucleic acids consisting of SEQ ID NO: 2221;
probe set #1363 consisting of the nucleic acids consisting of SEQ ID NO: 1620; 1632 and 1633;
probe set #1364 consisting of the nucleic acids consisting of SEQ ID NO: 12; 13 and 20;
probe set #1365 consisting of the nucleic acids consisting of SEQ ID NO: 2325; 2326 and 2327;
probe set #1366 consisting of the nucleic acids consisting of SEQ ID NO: 210; 211 and 212;
probe set #1367 consisting of the nucleic acids consisting of SEQ ID NO: 918; 927 and 932;
probe set #1368 consisting of the nucleic acids consisting of SEQ ID NO: 604; 605 and 606;
probe set #1369 consisting of the nucleic acids consisting of SEQ ID NO: 2454; 2455 and 2456;
probe set #1370 consisting of the nucleic acids consisting of SEQ ID NO: 467; 468 and 469;
probe set #1371 consisting of the nucleic acids consisting of SEQ ID NO: 488; 489 and 490;
probe set #1372 consisting of the nucleic acids consisting of SEQ ID NO: 904; 905 and 906;
probe set #1373 consisting of the nucleic acids consisting of SEQ ID NO: 289; 294 and 293;
probe set #1374 consisting of the nucleic acids consisting of SEQ ID NO: 1319; 1320 and 1321;
probe set #1375 consisting of the nucleic acids consisting of SEQ ID NO: 2394;
probe set #1376 consisting of the nucleic acids consisting of SEQ ID NO: 382; 383 and 384;
probe set #1377 consisting of the nucleic acids consisting of SEQ ID NO: 14; 15 and 16;
probe set #1378 consisting of the nucleic acids consisting of SEQ ID NO: 580 and 581;
probe set #1379 consisting of the nucleic acids consisting of SEQ ID NO: 1928; 1929 and 1930;
probe set #1380 consisting of the nucleic acids consisting of SEQ ID NO: 869; 870 and 874;
probe set #1381 consisting of the nucleic acids consisting of SEQ ID NO: 1433; 1434 and 1457;
probe set #1382 consisting of the nucleic acids consisting of SEQ ID NO: 892; 893 and 894;
probe set #1383 consisting of the nucleic acids consisting of SEQ ID NO: 884; 885 and 888;
probe set #1384 consisting of the nucleic acids consisting of SEQ ID NO: 295; 297 and 296;
probe set #1385 consisting of the nucleic acids consisting of SEQ ID NO: 2874;
probe set #1386 consisting of the nucleic acids consisting of SEQ ID NO: 1845; 1846 and 1847;
probe set #1387 consisting of the nucleic acids consisting of SEQ ID NO: 2604; 2606 and 2610;
probe set #1388 consisting of the nucleic acids consisting of SEQ ID NO: 1329; 1330 and 1331;
probe set #1389 consisting of the nucleic acids consisting of SEQ ID NO: 2461; 2462 and 2467;
probe set #1390 consisting of the nucleic acids consisting of SEQ ID NO: 234; 235 and 236;
probe set #1391 consisting of the nucleic acids consisting of SEQ ID NO: 1621; 1622 and 1623;
probe set #1392 consisting of the nucleic acids consisting of SEQ ID NO: 2879; 2880 and 2882;
probe set #1393 consisting of the nucleic acids consisting of SEQ ID NO: 761; 762 and 765;
probe set #1394 consisting of the nucleic acids consisting of SEQ ID NO: 1851; 1853 and 1854;
probe set #1395 consisting of the nucleic acids consisting of SEQ ID NO: 2138; 2139 and 2140;
probe set #1396 consisting of the nucleic acids consisting of SEQ ID NO: 627; 628 and 629;
probe set #1397 consisting of the nucleic acids consisting of SEQ ID NO: 574; 575 and 613;
probe set #1398 consisting of the nucleic acids consisting of SEQ ID NO: 2462;
probe set #1399 consisting of the nucleic acids consisting of SEQ ID NO: 2504; 2505 and 2506;
probe set #1400 consisting of the nucleic acids consisting of SEQ ID NO: 1908;
probe set #1401 consisting of the nucleic acids consisting of SEQ ID NO: 108; 109 and 110;
probe set #1402 consisting of the nucleic acids consisting of SEQ ID NO: 516; 517 and 518;
probe set #1403 consisting of the nucleic acids consisting of SEQ ID NO: 1496; 1506 and 1508;
probe set #1404 consisting of the nucleic acids consisting of SEQ ID NO: 507; 508 and 509;
probe set #1405 consisting of the nucleic acids consisting of SEQ ID NO: 2655; 2656 and 2657;
probe set #1406 consisting of the nucleic acids consisting of SEQ ID NO: 902; 911 and 902;
probe set #1407 consisting of the nucleic acids consisting of SEQ ID NO: 835 and 836;
probe set #1408 consisting of the nucleic acids consisting of SEQ ID NO: 2328; 2329 and 2330;
probe set #1409 consisting of the nucleic acids consisting of SEQ ID NO: 1316; 1317 and 1318;
probe set #1410 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1411 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1412 consisting of the nucleic acids consisting of SEQ ID NO: 1296; 1297 and 1302;
probe set #1413 consisting of the nucleic acids consisting of SEQ ID NO: 599; 600 and 601;
probe set #1414 consisting of the nucleic acids consisting of SEQ ID NO: 2239; 2240 and 2241;
probe set #1415 consisting of the nucleic acids consisting of SEQ ID NO: 1724; 1725 and 1726;
probe set #1416 consisting of the nucleic acids consisting of SEQ ID NO: 1803; 1804 and 1805;
probe set #1417 consisting of the nucleic acids consisting of SEQ ID NO: 1819 and 1820;
probe set #1418 consisting of the nucleic acids consisting of SEQ ID NO: 1872; 1873 and 1874;
probe set #1419 consisting of the nucleic acids consisting of SEQ ID NO: 398;
probe set #1420 consisting of the nucleic acids consisting of SEQ ID NO: 497;
probe set #1421 consisting of the nucleic acids consisting of SEQ ID NO: 770; 771 and 772;
probe set #1422 consisting of the nucleic acids consisting of SEQ ID NO: 2588; 2589 and 2590;
probe set #1423 consisting of the nucleic acids consisting of SEQ ID NO: 663; 664 and 665;
probe set #1424 consisting of the nucleic acids consisting of SEQ ID NO: 2919; 2920 and 2921;
probe set #1425 consisting of the nucleic acids consisting of SEQ ID NO: 2363; 2364 and 2365;
probe set #1426 consisting of the nucleic acids consisting of SEQ ID NO: 1363; 1364 and 1365;
probe set #1427 consisting of the nucleic acids consisting of SEQ ID NO: 2044; 2045 and 2048;
probe set #1428 consisting of the nucleic acids consisting of SEQ ID NO: 2388; 2389 and 2390;
probe set #1429 consisting of the nucleic acids consisting of SEQ ID NO: 2660; 2672 and 2708;
probe set #1430 consisting of the nucleic acids consisting of SEQ ID NO: 2892; 2893 and 2894;
probe set #1431 consisting of the nucleic acids consisting of SEQ ID NO: 944; 945 and 946;
probe set #1432 consisting of the nucleic acids consisting of SEQ ID NO: 1005; 1006 and 1007;
probe set #1433 consisting of the nucleic acids consisting of SEQ ID NO: 889; 895 and 896;
probe set #1434 consisting of the nucleic acids consisting of SEQ ID NO: 2524; 2525 and 2526;
probe set #1435 consisting of the nucleic acids consisting of SEQ ID NO: 2403;
probe set #1436 consisting of the nucleic acids consisting of SEQ ID NO: 461; 462 and 463;
probe set #1437 consisting of the nucleic acids consisting of SEQ ID NO: 385; 386 and 387;
probe set #1438 consisting of the nucleic acids consisting of SEQ ID NO: 2933; 2934 and 2935;
probe set #1439 consisting of the nucleic acids consisting of SEQ ID NO: 960;
probe set #1440 consisting of the nucleic acids consisting of SEQ ID NO: 23; 29 and 30;
probe set #1441 consisting of the nucleic acids consisting of SEQ ID NO: 210; 211 and 212;
probe set #1442 consisting of the nucleic acids consisting of SEQ ID NO: 1817; 1818 and 1821;
probe set #1443 consisting of the nucleic acids consisting of SEQ ID NO: 924; 925 and 926;
probe set #1444 consisting of the nucleic acids consisting of SEQ ID NO: 504; 505 and 506;
probe set #1445 consisting of the nucleic acids consisting of SEQ ID NO: 178; 179 and 180;
probe set #1446 consisting of the nucleic acids consisting of SEQ ID NO: 161; 162 and 163;
probe set #1447 consisting of the nucleic acids consisting of SEQ ID NO: 2114 and 2115;
probe set #1448 consisting of the nucleic acids consisting of SEQ ID NO: 461; 462 and 463;
probe set #1449 consisting of the nucleic acids consisting of SEQ ID NO: 2153; 2154 and 2155;
probe set #1450 consisting of the nucleic acids consisting of SEQ ID NO: 1441; 1442 and 1443;
probe set #1451 consisting of the nucleic acids consisting of SEQ ID NO: 1036; 1037 and 1038;
probe set #1452 consisting of the nucleic acids consisting of SEQ ID NO: 915; 916 and 917;
probe set #1453 consisting of the nucleic acids consisting of SEQ ID NO: 661; 662 and 666;
probe set #1454 consisting of the nucleic acids consisting of SEQ ID NO: 1326; 1327 and 1328;
probe set #1455 consisting of the nucleic acids consisting of SEQ ID NO: 2855; 2858 and 2859;
probe set #1456 consisting of the nucleic acids consisting of SEQ ID NO: 1842; 1843 and 1844;
probe set #1457 consisting of the nucleic acids consisting of SEQ ID NO: 1828; 1829 and 1830;
probe set #1458 consisting of the nucleic acids consisting of SEQ ID NO: 1659; 1660 and 1661;
probe set #1459 consisting of the nucleic acids consisting of SEQ ID NO: 2116; 2117 and 2118;
probe set #1460 consisting of the nucleic acids consisting of SEQ ID NO: 1642; 1643 and 1645;
probe set #1461 consisting of the nucleic acids consisting of SEQ ID NO: 2395;
probe set #1462 consisting of the nucleic acids consisting of SEQ ID NO: 1345; 1346 and 1347;
probe set #1463 consisting of the nucleic acids consisting of SEQ ID NO: 2003; 2004 and 2007;
probe set #1464 consisting of the nucleic acids consisting of SEQ ID NO: 2831; 2847 and 2848;
probe set #1465 consisting of the nucleic acids consisting of SEQ ID NO: 1702; 1703 and 1708;
probe set #1466 consisting of the nucleic acids consisting of SEQ ID NO: 2404; 2405 and 2406;
probe set #1467 consisting of the nucleic acids consisting of SEQ ID NO: 711; 712 and 713;
probe set #1468 consisting of the nucleic acids consisting of SEQ ID NO: 1494 and 1495;
probe set #1469 consisting of the nucleic acids consisting of SEQ ID NO: 570; 585 and 586;
probe set #1470 consisting of the nucleic acids consisting of SEQ ID NO: 1848; 1849 and 1850;
probe set #1471 consisting of the nucleic acids consisting of SEQ ID NO: 1439; 1440 and 1457;
probe set #1472 consisting of the nucleic acids consisting of SEQ ID NO: 877; 878 and 879;
probe set #1473 consisting of the nucleic acids consisting of SEQ ID NO: 568; 569 and 579;
probe set #1474 consisting of the nucleic acids consisting of SEQ ID NO: 1902; 1903 and 1904;
probe set #1475 consisting of the nucleic acids consisting of SEQ ID NO: 1426; 1427 and 1428;
probe set #1476 consisting of the nucleic acids consisting of SEQ ID NO: 1145; 1146 and 1147;
probe set #1477 consisting of the nucleic acids consisting of SEQ ID NO: 425; 426 and 427;
probe set #1478 consisting of the nucleic acids consisting of SEQ ID NO: 494; 495 and 496;
probe set #1479 consisting of the nucleic acids consisting of SEQ ID NO: 2116; 2117 and 2118;
probe set #1480 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1481 consisting of the nucleic acids consisting of SEQ ID NO: 897; 902 and 911;
probe set #1482 consisting of the nucleic acids consisting of SEQ ID NO: 1899; 1900 and 1901;
probe set #1483 consisting of the nucleic acids consisting of SEQ ID NO: 290; 292 and 291;
probe set #1484 consisting of the nucleic acids consisting of SEQ ID NO: 243; 244 and 245;
probe set #1485 consisting of the nucleic acids consisting of SEQ ID NO: 2502; 2503 and 2542;
probe set #1486 consisting of the nucleic acids consisting of SEQ ID NO: 1695; 1696 and 1697;
probe set #1487 consisting of the nucleic acids consisting of SEQ ID NO: 2617; 2620 and 2621;
probe set #1488 consisting of the nucleic acids consisting of SEQ ID NO: 1405; 1406 and 1410;
probe set #1489 consisting of the nucleic acids consisting of SEQ ID NO: 941; 954 and 955;
probe set #1490 consisting of the nucleic acids consisting of SEQ ID NO: 2814; 2815 and 2816;
probe set #1491 consisting of the nucleic acids consisting of SEQ ID NO: 2614; 2615 and 2616;
probe set #1492 consisting of the nucleic acids consisting of SEQ ID NO: 258; 259 and 260;
probe set #1493 consisting of the nucleic acids consisting of SEQ ID NO: 2260; 2261 and 2262;
probe set #1494 consisting of the nucleic acids consisting of SEQ ID NO: 2643; 2644 and 2645;
probe set #1495 consisting of the nucleic acids consisting of SEQ ID NO: 2337;
probe set #1496 consisting of the nucleic acids consisting of SEQ ID NO: 652; 653 and 654;
probe set #1497 consisting of the nucleic acids consisting of SEQ ID NO: 439; 440 and 441;
probe set #1498 consisting of the nucleic acids consisting of SEQ ID NO: 2817; 2818 and 2819;
probe set #1499 consisting of the nucleic acids consisting of SEQ ID NO: 1627; 1628 and 1629;
probe set #1500 consisting of the nucleic acids consisting of SEQ ID NO: 1496; 1505 and 1506;
probe set #1501 consisting of the nucleic acids consisting of SEQ ID NO: 1632; 1637 and 1638;
probe set #1502 consisting of the nucleic acids consisting of SEQ ID NO: 2411; 2412 and 2413;
probe set #1503 consisting of the nucleic acids consisting of SEQ ID NO: 1813; 1814 and 1815;
probe set #1504 consisting of the nucleic acids consisting of SEQ ID NO: 2557;
probe set #1505 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1506 consisting of the nucleic acids consisting of SEQ ID NO: 1496; 1497 and 1506;
probe set #1507 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1508 consisting of the nucleic acids consisting of SEQ ID NO: 1803; 1804 and 1809;
probe set #1509 consisting of the nucleic acids consisting of SEQ ID NO: 510; 511 and 512;
probe set #1510 consisting of the nucleic acids consisting of SEQ ID NO: 1928; 1929 and 1930;
probe set #1511 consisting of the nucleic acids consisting of SEQ ID NO: 2436; 2437 and 2460;
probe set #1512 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2607 and 2610;
probe set #1513 consisting of the nucleic acids consisting of SEQ ID NO: 1424; 1425 and 1450;
probe set #1514 consisting of the nucleic acids consisting of SEQ ID NO: 2111; 2112 and 2113;
probe set #1515 consisting of the nucleic acids consisting of SEQ ID NO: 1625; 1647 and 1648;
probe set #1516 consisting of the nucleic acids consisting of SEQ ID NO: 1624; 1625 and 1626;
probe set #1517 consisting of the nucleic acids consisting of SEQ ID NO: 498; 499 and 500;
probe set #1518 consisting of the nucleic acids consisting of SEQ ID NO: 2831; 2832 and 2848;
probe set #1519 consisting of the nucleic acids consisting of SEQ ID NO: 1878; 1879 and 1880;
probe set #1520 consisting of the nucleic acids consisting of SEQ ID NO: 869; 873 and 874;
probe set #1521 consisting of the nucleic acids consisting of SEQ ID NO: 990; 991 and 992;
probe set #1522 consisting of the nucleic acids consisting of SEQ ID NO: 1839; 1840 and 1841;
probe set #1523 consisting of the nucleic acids consisting of SEQ ID NO: 535; 536 and 537;
probe set #1524 consisting of the nucleic acids consisting of SEQ ID NO: 1325;
probe set #1525 consisting of the nucleic acids consisting of SEQ ID NO: 281; 283 and 282;
probe set #1526 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1527 consisting of the nucleic acids consisting of SEQ ID NO: 1491; 1492 and 1493;
probe set #1528 consisting of the nucleic acids consisting of SEQ ID NO: 897; 903 and 907;
probe set #1529 consisting of the nucleic acids consisting of SEQ ID NO: 2388; 2389 and 2390;
probe set #1530 consisting of the nucleic acids consisting of SEQ ID NO: 851 and 852;
probe set #1531 consisting of the nucleic acids consisting of SEQ ID NO: 2716;
probe set #1532 consisting of the nucleic acids consisting of SEQ ID NO: 1496; 1506 and 1508;
probe set #1533 consisting of the nucleic acids consisting of SEQ ID NO: 2672; 2682 and 2708;
probe set #1534 consisting of the nucleic acids consisting of SEQ ID NO: 529; 530 and 531;
probe set #1535 consisting of the nucleic acids consisting of SEQ ID NO: 1705; 1706 and 1707;
probe set #1536 consisting of the nucleic acids consisting of SEQ ID NO: 7; 8 and 9;
probe set #1537 consisting of the nucleic acids consisting of SEQ ID NO: 77; 78 and 79;
probe set #1538 consisting of the nucleic acids consisting of SEQ ID NO: 1322; 1323 and 1324;
probe set #1539 consisting of the nucleic acids consisting of SEQ ID NO: 2451; 2452 and 2453;
probe set #1540 consisting of the nucleic acids consisting of SEQ ID NO: 935 and 942;
probe set #1541 consisting of the nucleic acids consisting of SEQ ID NO: 2032; 2033 and 2034;
probe set #1542 consisting of the nucleic acids consisting of SEQ ID NO: 501; 502 and 503;
probe set #1543 consisting of the nucleic acids consisting of SEQ ID NO: 2350; 2351 and 2352;
probe set #1544 consisting of the nucleic acids consisting of SEQ ID NO: 728; 729 and 730;
probe set #1545 consisting of the nucleic acids consisting of SEQ ID NO: 610; 611 and 655;
probe set #1546 consisting of the nucleic acids consisting of SEQ ID NO: 22; 27 and 28;
probe set #1547 consisting of the nucleic acids consisting of SEQ ID NO: 862; 863 and 864;
probe set #1548 consisting of the nucleic acids consisting of SEQ ID NO: 1642; 1643 and 1644;
probe set #1549 consisting of the nucleic acids consisting of SEQ ID NO: 2438; 2439 and 2440;
probe set #1550 consisting of the nucleic acids consisting of SEQ ID NO: 2225; 2226 and 2227;
probe set #1551 consisting of the nucleic acids consisting of SEQ ID NO: 1639; 1640 and 1641;
probe set #1552 consisting of the nucleic acids consisting of SEQ ID NO: 2400; 2401 and 2402;
probe set #1553 consisting of the nucleic acids consisting of SEQ ID NO: 464; 465 and 466;
probe set #1554 consisting of the nucleic acids consisting of SEQ ID NO: 145; 146 and 147;
probe set #1555 consisting of the nucleic acids consisting of SEQ ID NO: 2391; 2392 and 2393;
probe set #1556 consisting of the nucleic acids consisting of SEQ ID NO: 7; 8 and 9;
probe set #1557 consisting of the nucleic acids consisting of SEQ ID NO: 1810; 1811 and 1812;
probe set #1558 consisting of the nucleic acids consisting of SEQ ID NO: 2311; 2312 and 2313;
probe set #1559 consisting of the nucleic acids consisting of SEQ ID NO: 1994;
probe set #1560 consisting of the nucleic acids consisting of SEQ ID NO: 1395 and 1396;
probe set #1561 consisting of the nucleic acids consisting of SEQ ID NO: 933; 936 and 953;
probe set #1562 consisting of the nucleic acids consisting of SEQ ID NO: 2830; 2836 and 2837;
probe set #1563 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1564 consisting of the nucleic acids consisting of SEQ ID NO: 80; 81 and 82;
probe set #1565 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1566 consisting of the nucleic acids consisting of SEQ ID NO: 1734; 1735 and 1736;
probe set #1567 consisting of the nucleic acids consisting of SEQ ID NO: 2441; 2442 and 2443;
probe set #1568 consisting of the nucleic acids consisting of SEQ ID NO: 2617; 2618 and 2619;
probe set #1569 consisting of the nucleic acids consisting of SEQ ID NO: 181; 182 and 183;
probe set #1570 consisting of the nucleic acids consisting of SEQ ID NO: 2649; 2650 and 2651;
probe set #1571 consisting of the nucleic acids consisting of SEQ ID NO: 47; 48 and 49;
probe set #1572 consisting of the nucleic acids consisting of SEQ ID NO: 1504; 1505 and 1506;
probe set #1573 consisting of the nucleic acids consisting of SEQ ID NO: 1053; 1054 and 1055;
probe set #1574 consisting of the nucleic acids consisting of SEQ ID NO: 1625; 1647 and 1648;
probe set #1575 consisting of the nucleic acids consisting of SEQ ID NO: 1878;
probe set #1576 consisting of the nucleic acids consisting of SEQ ID NO: 287; 1823 and 1824;
probe set #1577 consisting of the nucleic acids consisting of SEQ ID NO: 965; 966 and 967;
probe set #1578 consisting of the nucleic acids consisting of SEQ ID NO: 576; 577 and 578;
probe set #1579 consisting of the nucleic acids consisting of SEQ ID NO: 1498; 1499 and 1507;
probe set #1580 consisting of the nucleic acids consisting of SEQ ID NO: 2391; 2392 and 2393;
probe set #1581 consisting of the nucleic acids consisting of SEQ ID NO: 1862; 1863 and 1864;
probe set #1582 consisting of the nucleic acids consisting of SEQ ID NO: 516; 517 and 518;
probe set #1583 consisting of the nucleic acids consisting of SEQ ID NO: 1444; 1445 and 1446;
probe set #1584 consisting of the nucleic acids consisting of SEQ ID NO: 1627; 1628 and 1629;
probe set #1585 consisting of the nucleic acids consisting of SEQ ID NO: 774; 775 and 776;
probe set #1586 consisting of the nucleic acids consisting of SEQ ID NO: 2468; 2469 and 2470;
probe set #1587 consisting of the nucleic acids consisting of SEQ ID NO: 1730;
probe set #1588 consisting of the nucleic acids consisting of SEQ ID NO: 2404; 2405 and 2407;
probe set #1589 consisting of the nucleic acids consisting of SEQ ID NO: 2724; 2725 and 2733;
probe set #1590 consisting of the nucleic acids consisting of SEQ ID NO: 1642; 1644 and 1646;
probe set #1591 consisting of the nucleic acids consisting of SEQ ID NO: 2829; 2830 and 2837;
probe set #1592 consisting of the nucleic acids consisting of SEQ ID NO: 869; 870 and 874;
probe set #1593 consisting of the nucleic acids consisting of SEQ ID NO: 2866; 2867 and 2868;
probe set #1594 consisting of the nucleic acids consisting of SEQ ID NO: 1; 2 and 3;
probe set #1595 consisting of the nucleic acids consisting of SEQ ID NO: 243; 244 and 245;
probe set #1596 consisting of the nucleic acids consisting of SEQ ID NO: 2188; 2190 and 2191;
probe set #1597 consisting of the nucleic acids consisting of SEQ ID NO: 1498; 1499 and 1500;
probe set #1598 consisting of the nucleic acids consisting of SEQ ID NO: 491; 492 and 493;
probe set #1599 consisting of the nucleic acids consisting of SEQ ID NO: 615; 616 and 617;
probe set #1600 consisting of the nucleic acids consisting of SEQ ID NO: 661; 667 and 668;
probe set #1601 consisting of the nucleic acids consisting of SEQ ID NO: 96; 97 and 98;
probe set #1602 consisting of the nucleic acids consisting of SEQ ID NO: 2480; 2481 and 2482;
probe set #1603 consisting of the nucleic acids consisting of SEQ ID NO: 1698; 1699 and 1700;
probe set #1604 consisting of the nucleic acids consisting of SEQ ID NO: 2331; 2332 and 2333;
probe set #1605 consisting of the nucleic acids consisting of SEQ ID NO: 278; 279 and 280;
probe set #1606 consisting of the nucleic acids consisting of SEQ ID NO: 1910; 1911 and 1912;
probe set #1607 consisting of the nucleic acids consisting of SEQ ID NO: 243; 244 and 245;
probe set #1608 consisting of the nucleic acids consisting of SEQ ID NO: 1481; 1482 and 1483;
probe set #1609 consisting of the nucleic acids consisting of SEQ ID NO: 699; 700 and 701;
probe set #1610 consisting of the nucleic acids consisting of SEQ ID NO: 2605; 2606 and 2610;
probe set #1611 consisting of the nucleic acids consisting of SEQ ID NO: 189; 190 and 191;
probe set #1612 consisting of the nucleic acids consisting of SEQ ID NO: 2344; 2345 and 2346;
probe set #1613 consisting of the nucleic acids consisting of SEQ ID NO: 1803; 1804 and 1805;
probe set #1614 consisting of the nucleic acids consisting of SEQ ID NO: 259; 261 and 262;
probe set #1615 consisting of the nucleic acids consisting of SEQ ID NO: 934; 941 and 963;
probe set #1616 consisting of the nucleic acids consisting of SEQ ID NO: 284; 286 and 285;
probe set #1617 consisting of the nucleic acids consisting of SEQ ID NO: 2802; 2803 and 2804;
probe set #1618 consisting of the nucleic acids consisting of SEQ ID NO: 2121; 2122 and 2123;
probe set #1619 consisting of the nucleic acids consisting of SEQ ID NO: 2391; 2392 and 2393;
probe set #1620 consisting of the nucleic acids consisting of SEQ ID NO: 1936; 1937 and 1938;
probe set #1621 consisting of the nucleic acids consisting of SEQ ID NO: 1436; 1437 and 1438;
probe set #1622 consisting of the nucleic acids consisting of SEQ ID NO: 1807;
probe set #1623 consisting of the nucleic acids consisting of SEQ ID NO: 2823; 2824 and 2825;
probe set #1624 consisting of the nucleic acids consisting of SEQ ID NO: 1865; 1866 and 1867;
probe set #1625 consisting of the nucleic acids consisting of SEQ ID NO: 2886; 2887 and 2888;
probe set #1626 consisting of the nucleic acids consisting of SEQ ID NO: 1533;
probe set #1627 consisting of the nucleic acids consisting of SEQ ID NO: 2785; 2786 and 2787;
probe set #1628 consisting of the nucleic acids consisting of SEQ ID NO: 77; 78 and 86;
probe set #1629 consisting of the nucleic acids consisting of SEQ ID NO: 2640; 2641 and 2642;
probe set #1630 consisting of the nucleic acids consisting of SEQ ID NO: 2225; 2226 and 2228;
probe set #1631 consisting of the nucleic acids consisting of SEQ ID NO: 918; 919 and 920;
probe set #1632 consisting of the nucleic acids consisting of SEQ ID NO: 859; 860 and 861;
probe set #1633 consisting of the nucleic acids consisting of SEQ ID NO: 1919;
probe set #1634 consisting of the nucleic acids consisting of SEQ ID NO: 898; 903 and 911;
probe set #1635 consisting of the nucleic acids consisting of SEQ ID NO: 1429;
probe set #1636 consisting of the nucleic acids consisting of SEQ ID NO: 74; 75 and 76;
probe set #1637 consisting of the nucleic acids consisting of SEQ ID NO: 737; 738 and 739;
probe set #1638 consisting of the nucleic acids consisting of SEQ ID NO: 14; 15 and 16;
probe set #1639 consisting of the nucleic acids consisting of SEQ ID NO: 409; and
probe set #1640 consisting of the nucleic acids consisting of SEQ ID NO: 2038; 2039 and 2040.
7. A microarray comprising the group of polynucleotide probe sets according to claim 1.
8. A microarray comprising the combination of polynucleotide probe sets according to claim 2.
9. A microarray comprising the combination of polynucleotide probe sets according to claim 3.
10. A microarray comprising the combination of polynucleotide probe sets according to claim 4.
11. A microarray comprising the combination of polynucleotide probe sets according to claim 5.
12. A microarray comprising the combination of polynucleotide probe sets of claim 6.
US12/811,792 2008-01-04 2009-01-05 Molecular in vitro diagnosis of breast cancer Expired - Fee Related US8299233B2 (en)

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Application Number Priority Date Filing Date Title
EP08100106.7 2008-01-04
EP08100106 2008-01-04
EP08100106 2008-01-04
PCT/EP2009/050060 WO2009087139A1 (en) 2008-01-04 2009-01-05 Molecular in vitro diagnosis of breast cancer

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US20110009286A1 US20110009286A1 (en) 2011-01-13
US8299233B2 true US8299233B2 (en) 2012-10-30

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US13/550,872 Abandoned US20120283132A1 (en) 2008-01-04 2012-07-17 Molecular in vitro diagnosis of breast cancer

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