US6440444B2 - Load bearing osteoimplant and method of repairing bone using the same - Google Patents
Load bearing osteoimplant and method of repairing bone using the same Download PDFInfo
- Publication number
- US6440444B2 US6440444B2 US09/911,562 US91156201A US6440444B2 US 6440444 B2 US6440444 B2 US 6440444B2 US 91156201 A US91156201 A US 91156201A US 6440444 B2 US6440444 B2 US 6440444B2
- Authority
- US
- United States
- Prior art keywords
- bone
- osteoimplant
- bone particles
- composition
- mpa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- the present invention relates to an osteoimplant for use in the repair, replacement and/or augmentation of various portions of animal or human skeletal systems, to a method for manufacturing the osteoimplant and to a method of using the osteoimplant. More particularly, this invention relates to an osteogenic osteoimplant which provides mechanical or structural support to a bone repair site.
- Shaped or cut bone segments have been used extensively to solve various medical problems in human and animal orthopaedic surgical practice, and their application has also extended to the field of cosmetic and reconstructive surgery, dental reconstructive surgery, and other medical fields involving surgery of hard tissues.
- autograft bone where the patient provides the source
- allograft bone where another individual of the same species provides the source
- xenograft bone where another individual of a different species provides the source
- transplanted bone is known to provide support, promote healing, fill bony cavities, separate bony elements (such as vertebral bodies), promote fusion (where bones are induced to grow together into a single, solid mass), or stabilize the sites of fractures.
- processed bone has been developed into shapes for use in new surgical applications, or as new materials for implants that were historically made of non-biologically derived materials.
- Bone grafting applications are differentiated by the requirements of the skeletal site. Certain applications require a “structural graft” in which one role of the graft is to provide mechanical or structural support to the site. Such grafts contain a substantial portion of mineralized bone tissue to provide the strength needed for load-bearing. The graft may also have beneficial biological properties, such as incorporation into the skeleton, osteoinduction, osteoconduction, or angiogenesis.
- Structural grafts are conventionally made by processing, and then cutting or otherwise shaping cortical bones collected for transplant purposes.
- the range of bone grafts that might be thus prepared is limited by the size and shape limitations of the bone TISSUE from which the bone graft originated.
- Certain clinically desirable shapes and sizes of grafts may thus be unattainable by the cutting and shaping processes, due to the dimensional limitations of the bone. For some shapes they may also be available only in limited amounts, due to the large variations inherent in the human or animal donor source populations.
- a load-bearing osteoimplant which comprises a shaped, compressed composition of bone particles.
- the osteoimplant possesses a bulk density of greater than about 0.7 g/cm 3 and a wet compressive strength of at least about 3 MPa.
- the osteoimplant of this invention is fabricated by the method which comprises providing a composition comprising bone particles optionally in combination with one or more biocompatible components and applying compressive force of greater than about 1000 psi to the composition to provide a load-bearing osteoimplant.
- the bone particles utilized in the fabrication of the osteoimplant of this invention are selected from the group consisting of nondemineralized bone particles, demineralized bone particles, and combinations thereof.
- the bone particles are remodeled and replaced by new host bone as incorporation of the osteoimplant progresses in vivo.
- bone particles can be fully demineralized by removing substantially all of the inorganic mineral content of the bone particles, can be partially demineralized by removing a significant amount, but less than all, of the inorganic mineral content of the bone particles, or can be only superficially demineralized by removing a minor amount of the inorganic mineral content of the bone particles.
- demineralized as applied to the bone particles utilized in the practice of the present invention is intended to cover all bone particles which have had some portion of their original mineral content removed by a demineralization process.
- Nondemineralized bone particles provide strength to the osteoimplant and allow it to initially support load.
- Demineralized bone particles induce new bone formation at the site of the demineralized bone and permit adjustment of the overall mechanical properties of the osteoimplant.
- the osteoimplant of this invention optionally includes additional biocompatible component(s) such as wetting agents, biocompatible binders, fillers, fibers, plasticizers, biostatic/biocidal agents, surface active agents, bioactive agents, and the like.
- shaped refers to a determined or regular form or configuration, in contrast to an indeterminate or vague form or configuration (as in the case of a limp or other solid mass of no special form) and is characteristic of such materials as sheets, plates, disks, cores, pins, screws, tubes, teeth, bones, portion of bone, wedges, cylinders, threaded cylinders, and the like.
- wet compressive strength refers to the compressive strength of the osteoimplant after the osteoimplant has been immersed in physiological saline (water containing 0.9 g NaCl/100 ml water) for a minimum of 12 hours and a maximum of 24 hours.
- Compressive strength is a well known measurement of mechanical strength and is measured using the procedure described herein.
- osteoogenic as applied to the osteoimplant of this invention shall be understood as referring to the ability of the osteoimplant to enhance or accelerate the ingrowth of new bone tissue by one or more mechanisms such as osteogenesis, osteoconduction and/or osteoinduction.
- incorporación utilized herein refers to the biological mechanism whereby host tissue gradually removes portions of the osteoimplant of the invention and replaces those removed portions with native host bone tissue while maintaining strength. This phenomenon is also known in the scientific literature as “creeping substitution”.
- incorporación utilized herein shall be understood as embracing what is known by those skilled in the art as “creeping substitution”.
- FIGS. 1 a-h show various configurations of an osteoimplant of the present invention
- FIGS. 2 a and 2 b are views of a vertebrae and the osteoimplant of the invention sized and shaped as a disc (FIG. 2 a ) and threaded cylinder (FIG. 2 b ) for installation at an intervertebral site;
- FIG. 3 is a view of human cervical vertebrae showing an osteoimplant of the invention affixed thereto as a cervical plate;
- FIG. 4 is a view of the human skull showing an osteoimplant of the invention fashioned as a mandibular replacement;
- FIG. 5 is a cross-sectional view of a human femur showing implanted therein an osteoimplant fashioned as a femoral implant;
- FIGS. 6 a and 6 b show an embodiment of the osteoimplant of the present invention configured and dimensioned as an acetabular cup
- FIG. 7 is a view of a total hip replacement using the femoral implant depicted in FIG. 5 and the acetabular cup depicted in FIG. 6;
- FIGS. 8 a and 8 b are views of a human radius and ulna showing an osteoimplant of the invention fashioned as a diaphyseal plate being implanted at a bone fracture site (FIG. 8 a ) and as an intercalary implant implanted at a diaphyseal segment missing due to trauma or tumor (FIG. 8 b );
- FIG. 9 is a view of a human femur and an osteoimplant of the invention fashioned as an intramedullary rod positioned for installation in the medullary canal of the femur;
- FIG. 10 is a view of a femoral head and an osteoimplant of the invention positioned for installation in a core decompression site in the femoral head;
- FIG. 11 is a view of a human skull and an osteoimplant of the present invention positioned for implantation as a parietal bone replacement;
- FIGS. 12 a and 12 b show a cylindrical press-mold which can be utilized in the fabrication of the osteoimplant of the invention
- FIG. 13 shows a press which can be utilized in the fabrication of the osteoimplant of the invention.
- FIG. 14 shows a press and heating apparatus which can be utilized in the fabrication of the osteoimplant of the invention.
- the load-bearing osteoimplant of the present invention is produced by providing a composition comprising bone particles optionally in combination with one or more biocompatible components, and thereafter applying compressive force of at least about 1000 psi to the composition to provide a load-bearing osteoimplant.
- the osteoimplant fabricated in accordance with the invention possesses a bulk density of at least about 0.7 g/cm 3 and a wet compressive strength of at least about 3 MPa.
- the bone particle-containing composition can be heated, lyophilized and/or cross-linked either before, during or after the step of applying a compressive force to the bone particle-containing composition.
- the bone particles employed in the preparation of the bone particle-containing composition can be obtained from cortical, cancellous and/or corticocancellous bone which may be of autogenous, allogenic and/or xenogeneic origin.
- the bone particles are obtained from cortical bone of allogenic origin.
- Porcine and bovine bone are particularly advantageous types of xenogeneic bone tissue which can be used individually or in combination as sources for the bone particles.
- Particles are formed by milling whole bone to produce fibers, chipping whole bone, cutting whole bone, fracturing whole bone in liquid nitrogen, or otherwise disintegrating the bone tissue. Particles can optionally be sieved to produce those of a specific size.
- the bone particles employed in the composition can be powdered bone particles possessing a wide range of particle sizes ranging from relatively fine powders to coarse grains and even larger chips.
- powdered bone particles can range in average particle size from about 0.05 to about 1.2 cm and preferably from about 0.1 to about 1 cm and possess an average median length to median thickness ratio of from about 1:1 to about 3:1.
- powdered bone particles can be graded into different sizes to reduce or eliminate any less desirable size(s) of particles which may be present.
- bone particles generally characterized as elongate and possessing relatively high median length to median thickness ratios can be utilized herein.
- elongate particles can be readily obtained by any one of several methods, e.g., by milling or shaving the surface of an entire bone or relatively large section of bone.
- a mass of elongate bone particles containing at least about 60 weight percent, preferably at least about 70 weight percent, and most preferably at least about 80 weight percent of elongate bone particles possessing a median length of from about 2 to about 200 mm or more and preferably from about 10 to about 100 mm, a median thickness of from about 0.05 to about 2 mm, and preferably from about 0.2 to about 1 mm and a median width of from about 1 mm to about 20 mm, and preferably from about 2 to about 5 mm.
- elongate bone particles can possess a median length to median thickness ratio of at least about 50:1 up to about 500:1 or more, and preferably from about 50:1 to about 100:1 and a median length to median width ratio of from about 10:1 and about 200:1, and preferably from about 50:1 to about 100:1.
- Another procedure for obtaining elongate bone particles, particularly useful for pieces of bone of up to about 100 mm in length, is the bone processing mill described in commonly assigned U.S. Pat. No. 5,607,269. Use of this bone mill results in the production of long, thin strips which quickly curl lengthwise to provide tubular-like bone particles.
- elongate bone particles can be graded into different sizes to reduce or eliminate any less desirable size(s) of particles which may be present. In overall appearance, elongate bone particles can be described as filaments, fibers, threads, slender or narrow strips, etc.
- At least about 60 weight percent, more preferably at least about 75 weight percent, and most preferably at least about 90 weight percent of the bone particles utilized in the preparation of the bone particle-containing composition herein are elongate. It has been observed that elongate bone particles provide an osteoimplant possessing particularly good compressive strength.
- the bone particles are optionally demineralized in accordance with known and conventional procedures in order to reduce their inorganic mineral content.
- Demineralization methods remove the inorganic mineral component of bone by employing acid solutions. Such methods are well known in the art, see for example, Reddi et al., Proc. Nat. Acad. Sci. 69, pp1601-1605 (1972), incorporated herein by reference herein.
- the strength of the acid solution, the shape of the bone particles and the duration of the demineralization treatment will determine the extent of demineralization. Reference in this regard may be made to Lewandrowski et al., J. Biomed Materials Res, 31, pp 365-372 (1996), also incorporated herein by reference.
- the bone particles are subjected to a defatting/disinfecting step which is followed by an acid demineralization step.
- a preferred defatting/disinfectant solution is an aqueous solution of ethanol, the ethanol being a good solvent for lipids and the water being a good hydrophilic carrier to enable the solution to penetrate more deeply into the bone particles.
- the aqueous ethanol solution also disinfects the bone by killing vegetative microorganisms and viruses.
- the defatting disinfecting solution should be present in the defatting disinfecting solution to produce optimal lipid removal and disinfection within the shortest period of time.
- the preferred concentration range of the defatting solution is from about 60 to about 85 weight percent alcohol and most preferably about 70 weight percent alcohol.
- Acids which can be employed in this step include inorganic acids such as hydrochloric acid and organic acids such as peracetic acid. After acid treatment, the demineralized bone particles are rinsed with sterile water to remove residual amounts of acid and thereby raise the pH.
- wet demineralized bone particles can then be immediately shaped into any desired configuration or stored under aseptic conditions, advantageously in a lyophilized state, for processing at a later time.
- the particles can be shaped into a desired configuration and sterilized using known methods.
- one or more of the foregoing types of bone particles can be employed.
- one or more of the foregoing types of demineralized bone particles can be employed in combination with nondemineralized bone particles, i.e., bone particles that have not been subjected to a demineralization process.
- Demineralized bone particles likewise possess an initial and ongoing mechanical role, and later a biological role, in the osteoimplant of this invention.
- Superficial or partial demineralization produces particles containing a mineralized core. Particles of this type actually can contribute to the strength of the osteoimplant, through their mineralized core. These particles also play a biological role in bringing about new bone ingrowth by the process known as osteoinduction.
- Full demineralization produces particles in which nearly all of the mineral content has been removed from the particles. Particles treated in this way do not directly contribute to the strength of the osteoimplant; however, they do contribute to the osteoinductivity of the osteoimplant and provide a coherency or binding effect.
- the osteoimplant herein When prepared from bone particles that are almost exclusively nondemineralized and/or superficially demineralized the osteoimplant herein will tend to possess a fairly high compressive strength, e.g., one approaching and even exceeding that of natural bone. Accordingly, when an osteoimplant exhibiting a wet compressive strength of on the order of from about 20 to about 200 MPa, is desired, a predominant amount of nondemineralized bone particles and/or superficially demineralized bone particles can be advantageously employed. In order to lower the compressive strength of the osteoimplant, a quantity of partially or fully demineralized bone particles can be employed in combination with nondemineralized bone particles or superficially demineralized bone particles.
- the walls of the mold can be coated with a slurry or paste containing partially and/or fully demineralized bone particles followed by addition of a slurry or paste containing nondemineralized and/or superficially demineralized bone particles (or vice versa) to provide an osteoimplant which contains at least one discrete region, e.g., an outer surface, composed of partially and/or fully demineralized bone particles and at least one discrete region, e.g., a core, composed of nondemineralized and/or superficially demineralized bone particles.
- the amount of each individual type of bone particle employed can vary widely depending on the mechanical and biological properties desired.
- the weight ratio of nondemineralized to demineralized bone particles can broadly range from about 20:1 to about 1:20 and the weight ratio of superficially and/or partially demineralized bone particles to fully demineralized bone particles can broadly range from about 20:1 to about 1:20.
- Suitable amounts can be readily determined by those skilled in the art on a case-by-case basis by routine experimentation.
- the bone particle-containing composition fabricated in accordance with this disclosure will typically possess a bone particle content ranging from about 5 to about 100 weight percent, preferably from about 40 to about 99 weight percent, and more preferably from about 50 to about 95 weight percent, based on the weight of the entire composition calculated prior to compression of the composition.
- the bone particles can be combined with one or more biocompatible components such as wetting agents, biocompatible binders, fillers, fibers, plasticizers, biostatic/biocidal agents, surface active agents, bioactive agents, and the like, prior to, during, or after compressing the bone particle-containing composition.
- biocompatible components such as wetting agents, biocompatible binders, fillers, fibers, plasticizers, biostatic/biocidal agents, surface active agents, bioactive agents, and the like, prior to, during, or after compressing the bone particle-containing composition.
- One or more of such components can be combined with the bone particles by any suitable means, e.g., by soaking or immersing the bone particles in a solution or dispersion of the desired component, by physically admixing the bone particles and the desired component, and the like.
- Suitable wetting agents include biocompatible liquids such as water, organic protic solvent, aqueous solution such as physiological saline, concentrated saline solutions, sugar solutions, ionic solutions of any kind, and liquid polyhydroxy compounds such as glycerol and glycerol esters, and mixtures thereof.
- biocompatible liquids such as water, organic protic solvent, aqueous solution such as physiological saline, concentrated saline solutions, sugar solutions, ionic solutions of any kind, and liquid polyhydroxy compounds such as glycerol and glycerol esters, and mixtures thereof.
- wetting agents in general is preferred in the practice of the present invention, as they improve handling of bone particles.
- wetting agents will typically represent from about 20 to about 80 weight percent of the bone particle-containing composition, calculated prior to compression of the composition.
- Certain wetting agents such as water can be advantageously removed from the osteoimplant, e.g., by heating and lyophilizing the osteoimplant.
- Suitable biocompatible binders include biological adhesives such as fibrin glue, fibrinogen, thrombin, mussel adhesive protein, silk, elastin, collagen, casein, gelatin, albumin, keratin, chitin or chitosan; cyanoacrylates; epoxy-based compounds; dental resin sealants; bioactive glass ceramics (such as apatite-wollastonite), dental resin cements; glass ionomer cements (such as Ionocap® and Inocem® available from lonos Medizinische Kunststoffische Kunststoff GmbH, Greisberg, Germany); gelatin-resorcinol-formaldehyde glues; collagen-based glues; cellulosics such as ethyl cellulose; bioabsorbable polymers such as starches, polylactic acid, polyglycolic acid, polylactic-co-glycolic acid, polydioxanone, polycaprolactone, polycarbonates, polyorthoesters, polyamino acids, polyan
- plasticizers include liquid polyhydroxy compounds such as glycerol, monoacetin, diacetin, etc. Glycerol and aqueous solutions of glycerol are preferred. When employed, plasticizer will typically represent from about 20 to about 80 weight percent of the bone particle-containing composition, calculated prior to compression of the composition.
- bioactive substances can be incorporated in, or associated with, the bone particles.
- one or more bioactive substances can be combined with the bone particles by soaking or immersing the bone particles in a solution or dispersion of the desired bioactive substance(s).
- Bioactive substances include physiologically or pharmacologically active substances that act locally or systemically in the host.
- Bioactive substances which can be readily combined with the bone particles include, e.g., collagen, insoluble collagen derivatives, etc., and soluble solids and/or liquids dissolved therein; antiviricides, particularly those effective against HIV and hepatitis; antimicrobials and/or antibiotics such as erythromycin, bacitracin, neomycin, penicillin, polymycin B, tetracyclines, biomycin, chloromycetin, and streptomycins, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamicin, etc.; biocidal/biostatic sugars such as dextran, glucose, etc.; amino acids; peptides; vitamins; inorganic elements; co-factors for protein synthesis; hormones; endocrine tissue or tissue fragments; synthesizers; enzymes such as collagenase, peptidases, oxidases, etc.; polymer cell scaffolds with parenchymal cells; angi
- biocompatible components are not intended to be exhaustive and that other biocompatible components may be admixed with bone particles within the practice of the present invention.
- Specific polyhydroxy compounds of the foregoing type include glycerol and its monoesters and diesters derived from low molecular weight carboxylic acids, e.g., monoacetin and diacetin (respectively, glycerol monoacetate and glycerol diacetate), ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, trimethylolethane, trimethylolpropane, pentaerythritol, sorbitol, and the like.
- glycerol is especially preferred as it improves the handling characteristics of the bone particles wetted therewith and is biocompatible and easily metabolized.
- the bone particles have a tendency to quickly or prematurely separate or to otherwise settle out from the slurry or paste such that application of a fairly homogeneous composition is rendered difficult or inconvenient, it can be advantageous to include within the composition a substance whose thixotropic characteristics prevent or reduce this tendency.
- a thickener such as a solution of polyvinyl alcohol, polyvinylpyrrolidone, cellulosic ester such as hydroxypropyl methylcellulose, carboxy methylcellulose, pectin, xanthan gum, food-grade texturizing agent, gelatin, dextran, collagen, starch, hydrolyzed polyacrylonitrile, hydrolyzed polyacrylamide, polyelectrolyte such as polyacrylic acid salt, hydrogels, chitosan, other materials that can suspend particles, etc., can be combined with the wetting agent in an amount sufficient to significantly improve the suspension-keeping characteristics of the composition.
- the composition can be placed in a mold possessing any suitable or desired shape or configuration and compressed in a press, e.g., a Carver® manual press.
- a press e.g., a Carver® manual press.
- FIGS. 12 a and 12 b depict a cylindrical press-mold 10 which is suitable for use in the present invention.
- Mold 10 consists of three parts, a hollow cylinder 12 , an end cap 14 and a plunger 16 .
- Mold 10 is assembled by placing hollow cylinder 10 on top of end cap 12 .
- the interior of hollow cylinder 12 is then filled with the bone particle-containing composition described herein, shown at 18 .
- plunger 16 is placed on top of cylinder 10 which has been filled with bone particle-containing composition 18 .
- bone particle-containing composition 18 is filled to a height inside cylinder 12 which results in plunger 16 coming to a rest on composition 18 instead of cylinder 12 .
- FIG. 12 b depict a cylindrical press-mold 10 which is suitable for use in the present invention.
- Mold 10 consists of three parts, a hollow cylinder 12 , an end cap 14 and a plunger 16 .
- Mold 10 is assembled by placing hollow cylinder 10 on top of end cap 12 .
- mold 10 is placed inside a manual hydraulic press, generally depicted at 20 .
- Press 20 is equipped with two plates 22 and 24 .
- Plate 24 remains stationary while plate 22 moves in an upward direction as indicated by the arrow in FIG. 13 .
- Movement of plate 22 is hydraulically controlled by means of a handle or other means (not shown) which is operated by the user. As plate 22 moves upward, plunger 16 is forced against plate 24 and moves downward to apply compressive force against composition 18 inside mold 10 .
- the composition Before, during or after application of compressive force to the bone particle-containing composition, the composition can be subjected to an additional operation selected from heating, lyophilizing and cross-linking to further enhance the mechanical and/or biological properties of the osteoimplant.
- additional operation selected from heating, lyophilizing and cross-linking to further enhance the mechanical and/or biological properties of the osteoimplant.
- Incorporation of biocompatible component(s), if any, to the composition can precede or come after the step(s) of subjecting the composition to such additional operation(s).
- the composition is heated during or after the compression step.
- the composition can be heated at a suitable temperature, e.g., one ranging from about 30° to about 70° C., preferably from about 40° to about 50° C., for 1 to 72 hours preferably 24 to 48 hours.
- a presently preferred mode of heating involves placing the bone particle-containing composition in a mold and immersing the mold in a heated biocompatible liquid, e.g., water, glycerol, solution of glycerol and water, ionic solutions of any kind, saline, concentrated saline, etc., such that the liquid can communicate with the composition being compressed. Concentrated saline is preferred.
- the composition inside the mold is compressed to provide an osteoimplant in accordance with the present invention.
- mold 10 is placed in container 30 which is filled with biocompatible liquid 32 .
- a heat tape 34 Surrounding container 30 is a heat tape 34 which contains electric heating elements (not shown) which are controlled by an electrostat (not shown).
- electrostat an electrostat
- By raising the temperature of biocompatible liquid 32 heat is transferred to the composition (not shown) inside mold 10 .
- plate 22 moves upward, plunger 16 is compressed against plate 24 and exerts downward compressive force against the composition.
- biocompatible liquid 32 actually enters mold 10 through seams formed by the connection between end cap 14 and cylinder 12 and contacts the composition. It has been discovered that this mode of heating provides osteoimplants possessing particularly good strength characteristics.
- the osteoimplant can be lyophilized, advantageously after the bone particle-containing composition has been compressed in accordance with this disclosure, under conditions that are well known in the art, e.g., a shelf temperature of from about ⁇ 20° to about ⁇ 55° C., a vacuum of from about 150 to about 100 mTorr for a period of time ranging from about 4 to about 48 hours.
- Crosslinking can be performed in order to improve the strength of the osteoimplant.
- Crosslinking of the bone particle-containing composition can be effected by a variety of known methods including chemical reaction, the application of energy such as radiant energy, which includes irradiation by UV light or microwave energy, drying and/or heating and dye-mediated photo-oxidation; dehydrothermal treatment in which water is slowly removed while the bone particles are subjected to a vacuum; and, enzymatic treatment to form chemical linkages at any collagen-collagen interface.
- the preferred method of forming chemical linkages is by chemical reaction.
- Chemical crosslinking involves exposing the bone particles presenting surface-exposed collagen to the chemical crosslinking agent, either by contacting bone particles with a solution of the chemical crosslinking agent, or by exposing bone particles to the vapors of the chemical crosslinking agent under conditions appropriate for the particular type of crosslinking reaction.
- the osteoimplant of this invention can be immersed in a solution of cross-linking agent for a period of time sufficient to allow complete penetration of the solution into the osteoimplant.
- Crosslinking conditions include an appropriate pH and temperature, and times ranging from minutes to days, depending upon the level of crosslinking desired, and the activity of the chemical crosslinking agent. The resulting osteoimplant is then washed to remove all leachable traces of the chemical.
- Suitable chemical crosslinking agents include mono- and dialdehydes, including glutaraldehyde and formaldehyde; polyepoxy compounds such as glycerol polyglycidyl ethers, polyethylene glycol diglycidyl ethers and other polyepoxy and diepoxy glycidyl ethers; tanning agents including polyvalent metallic oxides such as titanium dioxide, chromium dioxide, aluminum dioxide, zirconium salt, as well as organic tannins and other phenolic oxides derived from plants; chemicals for esterification or carboxyl groups followed by reaction with hydrazide to form activated acyl azide functionalities in the collagen; dicyclohexyl carbodiimide and its derivatives as well as other heterobifunctional crosslinking agents; hexamethylene diisocyante; sugars, including glucose, will also crosslink collagen.
- polyepoxy compounds such as glycerol polyglycidyl ethers, polyethylene glycol diglycidyl
- useful enzymes include those known in the art which are capable of catalyzing crosslinking reactions on proteins or peptides, preferably collagen molecules, e.g., transglutaminase as described in Jurgensen et al., The Journal of Bone and Joint Surgery, 79-a (2), 185-193 (1997), herein incorporated by reference.
- Formation of chemical linkages can also be accomplished by the application of energy.
- One way to form chemical linkages by application of energy is to use methods known to form highly reactive oxygen ions generated from atmospheric gas, which in turn, promote oxygen crosslinks between surface-exposed collagen. Such methods include using energy in the form of ultraviolet light, microwave energy and the like.
- Another method utilizing the application of energy is a process known as dyemediated photo-oxidation in which a chemical dye under the action of visible light is used to crosslink surface-exposed collagen.
- Another method for the formation of chemical linkages is by dehydrothermal treatment which uses combined heat and the slow removal of water, preferably under vacuum, to achieve crosslinking of bone particles.
- the process involves chemically combining a hydroxy group from a functional group of one collagen molecule and a hydrogen ion from a functional group of another collagen molecule reacting to form water which is then removed resulting in the formation of a bond between the collagen molecules.
- the resulting osteoimplant can assume a determined or regular form or configuration such as a sheet, plate, disk, cone, pin, screw, tube, tooth, tooth root, bone or portion of bone, wedge or portion of wedge, cylinder, threaded cylinder (dowel), to name but a few.
- the osteoimplant can be machined or shaped by any suitable mechanical shaping means.
- Computerized modeling can, for example, be employed to provide an intricately-shaped osteoimplant which is custom-fitted to the bone repair site with great precision.
- the osteoimplant possesses the configuration of a threaded cylinder (dowel).
- the osteoimplant herein is applied at a bone repair site, e.g., one resulting from injury, defect brought about during the course of surgery, infection, malignancy or developmental malformation, which requires mechanical support.
- the osteoimplant can be utilized in a wide variety of orthopaedic, periodontal, neurosurgical and oral and maxillofacial surgical procedures such as the repair of simple and compound fractures and non-unions, external and internal fixations, joint reconstructions such as arthrodesis, general arthroplasty, cup arthroplasty of the hip, femoral and humeral head replacement, femoral head surface replacement and total joint replacement, repairs of the vertebral column including spinal fusion and internal fixation, tumor surgery, e.g., deficit filling, discectomy, laminectomy, excision of spinal cord tumors, anterior cervical and thoracic operations, repairs of spinal injuries, scoliosis, lordosis and kyphosis treatments, intermaxillary fixation of fractures, mentoplasty, tempo
- Specific bones which can be repaired or replaced with the bonederived implant herein include the ethmoid, frontal, nasal, occipital, parietal, temporal, mandible, maxilla, zygomatic, cervical vertebra, thoracic vertebra, lumbar vertebra, sacrum, rib, sternum, clavicle, scapula, humerus, radius, ulna, carpal bones, metacarpal bones, phalanges, ilium, ischium, pubis, femur, tibia, fibula, patella, calcaneus, tarsal and metatarsal bones.
- the osteoimplant can be implanted at the bone repair site, if desired, using any suitable affixation means, e.g., sutures, staples, bioadhesives, and the like.
- FIGS. 1 a-h depict various embodiments of an osteoimplant according to the present invention configured and dimensioned in the shape of a cylinder 40 , wedge 50 , plate 60 , threaded cylinder (dowel) 70 , fibular wedge 62 , femoral struts 64 , 66 and tibial strut 68 .
- cylinder 20 and wedge 30 are provided with macroporosity, namely holes 42 and 52 , respectively, which have been drilled into cylinder 40 and wedge 50 . Macroporosity promotes blood flow through the osteoimplant and enhances and accelerates the incorporation of the osteoimplant by the host.
- macroporous holes 42 and 52 can be advantageously filled with an osteogenic material, e.g., Grafton® putty available from Osteotech, Inc., Eastontown, N.J.
- osteoimplant 80 is configured and dimensioned as a disk to be inserted into the intervertebral fibrocartilage site 82 on the anterior side of vertebral column 84 .
- osteoimplant 70 is configured and dimensioned as a threaded cylinder (as depicted in FIG. 1 d ) to be inserted into the intervertebral site 72 on the anterior side of vertebral column 84 .
- the osteoimplant of the invention is configured and dimensioned as a cervical plate 90 and is shown affixed to cervical vertebrae 94 , 96 by bone screws 92 .
- bone screws 92 form yet another embodiment of the osteoimplant of the present invention.
- the osteoimplant 100 of the invention is sized and shaped to form the mandible of skull 102 .
- the osteoimplant 110 of the invention is sized and shaped as a femoral implant.
- Osteoimplant 110 comprises head 112 which is attached to ball 114 .
- Ball 114 is fabricated from plastic or metal and is affixed to osteoimplant 110 by any suitable means, e.g, screw 116 .
- Osteoimplant is inserted into intramedullary canal 118 of femur 120 .
- the osteoimplant 130 of the invention is sized and shaped as an acetabular cup which is configured and dimensioned to receive plastic or metallic liner 132 .
- FIG. 7 a total hip replacement with the osteoimplant 110 depicted in FIG. 5 and the osteoimplant 130 of FIGS. 6 a and 6 b is depicted.
- the osteoimplant 140 of the invention is sized and shaped as a diaphyseal implant and is shown being implanted via bone screws 142 on a fracture 144 along the diaphyseal segment of a human radius 146 .
- screws 142 can be fabricated from compressed bone particles in accordance with this disclosure.
- osteoimplant 180 of the invention is sized and shaped as an intercalary implant and is shown already implanted at a diaphyseal segment of human radius 146 that is missing due to trauma or tumor.
- the osteoimplant 150 of the invention is sized and shaped as an intramedullary rod for insertion into the medullary canal 154 of femur 152 .
- osteoimplant 186 is sized and shaped as a reinforcement rod for insertion into a core decompression site 184 formed by drilling a hole into femoral head 182 .
- osteoimplant 160 is sized and shaped to form part of the parietal bone 162 for skull 164 . Osteoimplant 160 promotes fusion with parietal bone 88 .
- the present invention is intended to embrace all such devices which are constructed as the osteoimplant of the present invention and the attendant uses of such devices.
- Initial density is determined by measuring specimen dimensions with a caliper to determine volume, and then weighing the specimen on a laboratory balance. The specimen is then placed in a container with 0.9% NaCl solution at room temperature for 12-24 hours. After the hydration period, the specimen is measured again to determine dimensions, and dimensions are recorded. The specimen is then centered on a compression platen (MTS 643.10A-01) in a servohydraulic testing system (MTS 858 Bionix). The top platen is lowered onto the specimen until a compressive preload of 0.1 kN is achieved. The system displacement transducer is then zeroed (MTS 358.10), defining zero displacement as the displacement associated initially with 0.1 kN preload.
- the specimen is loaded in the displacement mode, using a ramp compressive load of 0.5 mm/s, until an endpoint of 4 mm displacement is achieved. After the 4 mm displacement is achieved, the loading is stopped automatically, and the specimen is unloaded. During testing, load (from the system load cell MTS 661.20E-03) and displacement data are collected every 0.05 sec.
- Example 1 The procedure of Example 1 was used except the ratio of fully demineralized to nondemineralized bone particles was 2:1, the pellet was heated in situ in an oven for 4 hours at 40° C. and the pressure was 2,500 psi. The resulting compressed pellet was cut into two portions and each portion was treated with crosslinking agent: 10% neutral buffered formalin (both dipped and in vapor phase) and 4% Denacol EX313 (a polyepoxy-ether compound available from Nagase America Corp., New York, N.Y.), respectively. In each case, the resulting osteoimplant swelled a little and became stiff, and resistant to manual pressure. The bulk density of the osteoimplant produced was 1.2 g/cm 3 . The wet compressive strength of the osteoimplant exceeded 3 MPa.
- Example 1 The procedure of Example 1 was followed except that all of the particles were partially demineralized by using 225 ml of 0.6N HCl and allowing the acid to react to depletion. Additionally, the mold was hexagonal in configuration (with each side of the hexagon measuring 18 mm). After completing the freeze-drying step, the resulting osteoimplant was placed in a bath of 10% neutral buffered formalin and the exposed collagen of the partially demineralized bone particles was allowed to cross-link for 48 hours. The resulting dry osteoimplant was tested mechanically and was found to possess a dry compressive strength of about 85 MPa. The bulk density of the osteoimplant was 1.05 g/cm 3 .
- Example 3 The procedure of Example 3 was repeated and the resulting osteoimplant was immersed in physiological saline for 12-24 hours and was found to possess an ultimate wet compressive strength of about 45 MPa.
- the bulk density of the osteoimplant was 1.05 g/cm 3 .
- Elongate bone particles were prepared using a milling machine. The nondemineralized particles were then combined with ethyl cellulose (3:2 ratio by weight), and covered with 70% ethanol for 30 minutes, with stirring. The elongate bone particles were then removed from the solution by straining, and placed into a press-mold while still moist. The elongate bone particles were pressed to 10,000 psi for 15 minutes. The resulting compressed pellet was heated in situ in an oven for 4 hours at 45° C. The implant was then frozen in a ⁇ 70° C. freezer (overnight), and freeze-dried, after which it was removed from the mold. The osteoimplant was immersed in physiological saline overnight and was found to possess a wet compressive strength of 20 MPa.
- Bone particles were prepared by using a block plane on the periosteal surface of cortical bone. Half of the volume of the bone particles was fully demineralized using two changes of 0.6N HCl acid. The mineralized (25 g) and the demineralized particles (25 g based on original weight) were then combined together in a 70% ethanol solution with 20 g ethyl cellulose. This mixture was stirred for 30 minutes at room temperature. The particles were then removed form the solution by straining, and placed into a cylindrical press-mold while still moist. The particles were pressed to 18,000 psi for 10 minutes. The resulting compressed pellet was heated in situ in an oven for 4 hours at 45° C. The implant was then frozen in a ⁇ 70° C. freezer (1.5 hours), and freeze-dried overnight, after which it was removed from the mold. The dry compressive strength of the osteoimplant was 6.5 MPa and the wet compressive strength of the osteoimplant was 4.0 MPa.
- Elongate bone particles were prepared using a milling machine (30 g). An equivalent amount by weight of cortical bone chips were also prepared by grinding in a bone mill. Chips were sieved between screens having dimensions between 4.0 mm and 1.8 mm. The elongate particles and the chips were then combined together in a container with 70% Ethanol (1 liter) and ethyl cellulose (20 g). The components were mixed together thoroughly and allowed to soak for 30 minutes at room temperature. The mixture was then removed from the excess solution by straining, and placed into a pressmold while still moist. The particles were pressed to 10,000 psi for 10 minutes. The resulting compressed pellet was heated in situ in an oven for 4 hours at 45° C. The implant was then frozen in a ⁇ 70° C. freezer (1.5 hours), and freeze-dried overnight, after which it was removed from the mold. The wet compressive strength of the osteoimplant exceeded 3 MPa.
- elongate bone particles Twenty grams of elongate bone particles were produced by milling from diaphyseal bone. The nondemineralized elongate bone particles were mixed with 10 grams dry ethyl cellulose. To this mixture, 150 ml of 95% ethanol was added, and the mixture was stirred for 30 minutes. The fluid was then drained off, and 20 ml of elongate bone particles was measured out and placed in a cylindrical press-mold. The elongate bone particles were pressed for 10 minutes at 56,000 psi. After pressing, the pellet, still in its mold, was placed in an oven at 45° C. for 4 hours, and then in a ⁇ 70° C. freezer overnight. The pellet was freeze-dried for about 3 days.
- the resulting osteoimplant (10 mm dia. by 9.1 mm high cylinder) was then re-hydrated overnight in physiological saline (water containing 0.9 g NaCl/100 ml water).
- physiological saline water containing 0.9 g NaCl/100 ml water.
- the wet compressive strength of the osteoimplant was 31.9 MPa.
- Elongate bone particles were produced by milling from diaphyseal bone. These elongate bone particles were then partially demineralized using 14 ml of 0.6 HCl acid solution. The acid was allowed to react to exhaustion (pH ⁇ 7). The partially demineralized elongate bone particles were then washed in water, and placed into a 13 mm cylindrical press-mold. The filled mold was placed in a heated water bath made by surrounding an open-topped metal flask with a heating strip. The water was heated continuously to 70° C. during the pressing process. The bone particles were pressed at 120,000 psi for 3 days. The pellet produced was placed in a ⁇ 70° C. freezer for 1 hour, then freeze-dried for 24 hours. The resulting osteoimplant had a bulk density of 1.9 g/cm 3 . This osteoimplant was rehydrated overnight in physiological saline, and then tested for wet compressive strength. The resulting wet compressive strength was 56.4 MPa.
- An osteoimplant was prepared as in Example 9, except that the bone particles used were 100-500 ⁇ m powder, superficially demineralized with 0.6N HCl.
- the mold size was 10 mm diameter for this example.
- the resulting osteoimplant had a bulk density of 1.9 g/cm 3 and a wet compressive strength of 17.6 MPa.
- An osteoimplant was prepared as in Example 9, except that the elongate bone particles were pressed in a 10 mm diameter mold for 24 hours at 40° C.
- the resulting osteoimplant had a bulk density of 1.8 g/cm 3 , and a wet compressive strength of 41.6 MPa.
- An osteoimplant was prepared as in Example 9, except that the elongate bone particles were placed in a 50% aqueous solution of glycerol and were pressed in a 10 mm diameter mold surrounded by heated 50% aqueous solution of glycerol at 40° C. The implant was pressed to 40,000 psi for 24 hours. The resulting osteoimplant had a bulk density of 1.6 g/cm 3 , and a wet compressive strength of 12.5 MPa.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Surgery (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
Abstract
Description
Claims (30)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/911,562 US6440444B2 (en) | 1999-02-23 | 2001-07-24 | Load bearing osteoimplant and method of repairing bone using the same |
US10/229,767 US6696073B2 (en) | 1999-02-23 | 2002-08-27 | Shaped load-bearing osteoimplant and methods of making same |
US10/736,799 US8133421B2 (en) | 1999-02-23 | 2003-12-16 | Methods of making shaped load-bearing osteoimplant |
US11/758,751 US20070233272A1 (en) | 1999-02-23 | 2007-06-06 | Shaped load-bearing osteoimplant and methods of making same |
US13/370,107 US20120143334A1 (en) | 1999-02-23 | 2012-02-09 | Shaped load-bearing osteoimplant and methods of making the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/256,447 US6294187B1 (en) | 1999-02-23 | 1999-02-23 | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US09/911,562 US6440444B2 (en) | 1999-02-23 | 2001-07-24 | Load bearing osteoimplant and method of repairing bone using the same |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/256,447 Continuation US6294187B1 (en) | 1999-02-23 | 1999-02-23 | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/229,767 Continuation-In-Part US6696073B2 (en) | 1999-02-23 | 2002-08-27 | Shaped load-bearing osteoimplant and methods of making same |
Publications (2)
Publication Number | Publication Date |
---|---|
US20010043940A1 US20010043940A1 (en) | 2001-11-22 |
US6440444B2 true US6440444B2 (en) | 2002-08-27 |
Family
ID=22972272
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/256,447 Expired - Lifetime US6294187B1 (en) | 1999-02-23 | 1999-02-23 | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US09/911,562 Expired - Lifetime US6440444B2 (en) | 1999-02-23 | 2001-07-24 | Load bearing osteoimplant and method of repairing bone using the same |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/256,447 Expired - Lifetime US6294187B1 (en) | 1999-02-23 | 1999-02-23 | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
Country Status (10)
Country | Link |
---|---|
US (2) | US6294187B1 (en) |
EP (1) | EP1152777B1 (en) |
JP (1) | JP4658331B2 (en) |
KR (1) | KR100754814B1 (en) |
AU (1) | AU758828B2 (en) |
CA (1) | CA2363153C (en) |
DE (1) | DE60027698T2 (en) |
ES (1) | ES2261191T3 (en) |
TR (1) | TR200102480T2 (en) |
WO (1) | WO2000050102A1 (en) |
Cited By (190)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020052654A1 (en) * | 1999-05-10 | 2002-05-02 | C.R. Bard, Inc. | Prosthetic repair fabric |
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US20030033021A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
US6558422B1 (en) * | 1999-03-26 | 2003-05-06 | University Of Washington | Structures having coated indentations |
US6632247B2 (en) | 2000-03-22 | 2003-10-14 | Synthes (Usa) | Implants formed of coupled bone |
US20030216777A1 (en) * | 2002-05-16 | 2003-11-20 | Yin-Chun Tien | Method of enhancing healing of interfacial gap between bone and tendon or ligament |
US20040003757A1 (en) * | 1999-07-14 | 2004-01-08 | Cana Lab Corporation | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface |
US20040010314A1 (en) * | 2002-06-12 | 2004-01-15 | Pentax Corporation | Bone replacement material |
US20040024457A1 (en) * | 2000-12-08 | 2004-02-05 | Boyce Todd M. | Implant for orthopedic applications |
US20040031420A1 (en) * | 2000-07-13 | 2004-02-19 | Lin Jiin-Huey Chern | Calcium phosphate cement, use and preparation thereof |
US20040059431A1 (en) * | 2000-08-04 | 2004-03-25 | Plouhar Pamela L. | Reinforced small intestinal submucosa |
US6732738B1 (en) * | 1999-09-30 | 2004-05-11 | Masashi Komeda | Method to enhance healing of sternum after sternotomy |
US20040137032A1 (en) * | 2002-03-15 | 2004-07-15 | Wang Francis W. | Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts |
US6776800B2 (en) | 2001-02-28 | 2004-08-17 | Synthes (U.S.A.) | Implants formed with demineralized bone |
US20040175320A1 (en) * | 1999-07-14 | 2004-09-09 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same |
US20040220574A1 (en) * | 2001-07-16 | 2004-11-04 | Pelo Mark Joseph | Device from naturally occuring biologically derived materials |
US20050069479A1 (en) * | 1999-07-14 | 2005-03-31 | Calcitec, Inc. | Method of increasing working time of tetracalcium phosphate cement paste |
US20050076813A1 (en) * | 1999-07-14 | 2005-04-14 | Calcitec, Inc. | Process for producing fast-setting, bioresorbable calcium phosphate cements |
US20050101964A1 (en) * | 2003-11-07 | 2005-05-12 | Calcitec, Inc. | Spinal fusion procedure using an injectable bone substitute |
US20050184418A1 (en) * | 2004-02-19 | 2005-08-25 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US20050229323A1 (en) * | 2004-04-20 | 2005-10-20 | Mills C R | Process and apparatus for treating implants comprising soft tissue |
US20050244239A1 (en) * | 2002-05-30 | 2005-11-03 | Shimp Lawrence A | Method and apparatus for machining a surgical implant |
US20050244450A1 (en) * | 2004-04-28 | 2005-11-03 | Reddi A H | Heat-treated implantable bone material |
US20050244457A1 (en) * | 2004-04-28 | 2005-11-03 | Reddi A H | Irradiated implantable bone material |
US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
US20050263929A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050268821A1 (en) * | 2000-07-13 | 2005-12-08 | Cana Lab Corporation | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US20050274287A1 (en) * | 2000-07-13 | 2005-12-15 | Lin Jiin-Huey C | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US20050283255A1 (en) * | 2001-06-04 | 2005-12-22 | Perry Geremakis | Tissue-derived mesh for orthopedic regeneration |
US20060015184A1 (en) * | 2004-01-30 | 2006-01-19 | John Winterbottom | Stacking implants for spinal fusion |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060084602A1 (en) * | 2004-10-14 | 2006-04-20 | Lynch Samuel E | Platelet-derived growth factor compositions and methods of use thereof |
US7045141B2 (en) | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US20060111786A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty |
US7118705B2 (en) | 2003-08-05 | 2006-10-10 | Calcitec, Inc. | Method for making a molded calcium phosphate article |
US20060228252A1 (en) * | 2004-04-20 | 2006-10-12 | Mills C R | Process and apparatus for treating implants comprising soft tissue |
US20060229723A1 (en) * | 2005-04-08 | 2006-10-12 | Sdgi Holdings, Inc. | Intervertebral fusion device and method |
US20060233851A1 (en) * | 2005-04-13 | 2006-10-19 | Ebi, L.P. | Composite bone graft material |
US20060233849A1 (en) * | 2005-04-13 | 2006-10-19 | Simon Bruce J | Composite bone graft material |
US20060258578A1 (en) * | 2005-05-10 | 2006-11-16 | The University Of Zurich | Pharmaceutical composition |
US20060271052A1 (en) * | 2005-05-12 | 2006-11-30 | Stern Joseph D | Revisable anterior cervical plating system |
US20070075016A1 (en) * | 2005-08-23 | 2007-04-05 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
US20070074980A1 (en) * | 2005-09-02 | 2007-04-05 | Bankoski Brian R | Implant rehydration packages and methods of use |
US20070083205A1 (en) * | 2005-09-26 | 2007-04-12 | Mohamed Attawia | Tissue augmentation, stabilization and regeneration Technique |
US20070129807A1 (en) * | 2004-10-14 | 2007-06-07 | Lynch Samuel E | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
US20070154563A1 (en) * | 2003-12-31 | 2007-07-05 | Keyvan Behnam | Bone matrix compositions and methods |
US20070162128A1 (en) * | 2005-12-16 | 2007-07-12 | Sdgi Holdings, Inc. | Intervertebral spacer and insertion tool |
US20070208321A1 (en) * | 2005-08-23 | 2007-09-06 | Biomet Manufacturing Corp. | Method And Apparatus For Collecting Biological Materials |
US20070233246A1 (en) * | 2006-03-31 | 2007-10-04 | Sdgi Holdings, Inc. | Spinal implants with improved mechanical response |
US20070233272A1 (en) * | 1999-02-23 | 2007-10-04 | Boyce Todd M | Shaped load-bearing osteoimplant and methods of making same |
US20070270971A1 (en) * | 2006-03-14 | 2007-11-22 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc with improved wear resistance |
US20080021557A1 (en) * | 2006-07-24 | 2008-01-24 | Warsaw Orthopedic, Inc. | Spinal motion-preserving implants |
US20080021462A1 (en) * | 2006-07-24 | 2008-01-24 | Warsaw Orthopedic Inc. | Spinal stabilization implants |
US20080125784A1 (en) * | 2006-11-10 | 2008-05-29 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US20080188945A1 (en) * | 1999-02-23 | 2008-08-07 | Boyce Todd M | Shaped load-bearing osteoimplant and methods of making same |
US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
US20090074871A1 (en) * | 2007-09-14 | 2009-03-19 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US7517358B2 (en) | 2004-11-22 | 2009-04-14 | Orthopedic Development Corporation | Implant device used in minimally invasive facet joint hemi-arthroplasty |
WO2009120248A1 (en) | 2008-03-28 | 2009-10-01 | Osteotech, Inc. | Delivery system attachment |
US20090269388A1 (en) * | 2002-05-20 | 2009-10-29 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US7682392B2 (en) * | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
US20100082072A1 (en) * | 2008-03-28 | 2010-04-01 | Sybert Daryl R | Bone anchors for orthopedic applications |
US7708761B2 (en) | 2004-11-22 | 2010-05-04 | Minsurg International, Inc. | Spinal plug for a minimally invasive facet joint fusion system |
US7708740B1 (en) | 2000-01-14 | 2010-05-04 | Marctec, Llc | Method for total knee arthroplasty and resecting bone in situ |
US20100151114A1 (en) * | 2008-12-17 | 2010-06-17 | Zimmer, Inc. | In-line treatment of yarn prior to creating a fabric |
WO2010093955A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech,Inc. | Segmented delivery system |
US20100211158A1 (en) * | 2007-10-16 | 2010-08-19 | Hkpb Scientific Limited | Surface coating processes and uses of same |
US7780860B2 (en) | 2002-05-24 | 2010-08-24 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7799754B2 (en) | 2004-10-14 | 2010-09-21 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
US7806900B2 (en) | 2006-04-26 | 2010-10-05 | Illuminoss Medical, Inc. | Apparatus and methods for delivery of reinforcing materials to bone |
US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
US7811290B2 (en) | 2006-04-26 | 2010-10-12 | Illuminoss Medical, Inc. | Apparatus and methods for reinforcing bone |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US20100268228A1 (en) * | 2009-03-20 | 2010-10-21 | Minsurg International, Inc. | Surgical methods and tools |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7837884B2 (en) | 2002-05-03 | 2010-11-23 | Hanuman, Llc | Methods and apparatus for isolating platelets from blood |
US20100297082A1 (en) * | 2009-05-19 | 2010-11-25 | Osteotech, Inc. | Weight-bearing polyurethane composites and methods thereof |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US7879041B2 (en) | 2006-11-10 | 2011-02-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
WO2011017284A2 (en) | 2009-08-03 | 2011-02-10 | Osteotech, Inc. | Bone matrix compositions and methods |
US20110040279A1 (en) * | 2009-08-12 | 2011-02-17 | Medtronic, Inc. | Particle Delivery |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
USRE42208E1 (en) | 2003-04-29 | 2011-03-08 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US7943573B2 (en) | 2008-02-07 | 2011-05-17 | Biomimetic Therapeutics, Inc. | Methods for treatment of distraction osteogenesis using PDGF |
US7959635B1 (en) | 2000-01-14 | 2011-06-14 | Marctec, Llc. | Limited incision total joint replacement methods |
US20110150963A1 (en) * | 2009-12-21 | 2011-06-23 | Clineff Theodore D | Bioactive antibacterial bone graft materials |
US20110182849A1 (en) * | 2010-01-28 | 2011-07-28 | Warsaw Orthopedic, Inc. | Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents |
US20110189253A1 (en) * | 2010-01-29 | 2011-08-04 | Warsaw Orthopedic, Inc. | Biomaterial composition and method |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US8012210B2 (en) | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
US8021392B2 (en) | 2004-11-22 | 2011-09-20 | Minsurg International, Inc. | Methods and surgical kits for minimally-invasive facet joint fusion |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US8070749B2 (en) | 2005-05-12 | 2011-12-06 | Stern Joseph D | Revisable anterior cervical plating system |
US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
US8128627B2 (en) | 2007-03-22 | 2012-03-06 | Sonoma Orthopedic Products, Inc. | Segmented intramedullary system and apparatus |
US8202539B2 (en) | 2007-10-19 | 2012-06-19 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
US8210729B2 (en) | 2009-04-06 | 2012-07-03 | Illuminoss Medical, Inc. | Attachment system for light-conducting fibers |
US8292968B2 (en) | 2004-10-12 | 2012-10-23 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US8337711B2 (en) | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
US8357384B2 (en) | 2007-06-15 | 2013-01-22 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US8403968B2 (en) | 2007-12-26 | 2013-03-26 | Illuminoss Medical, Inc. | Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US8492335B2 (en) | 2010-02-22 | 2013-07-23 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
US8497023B2 (en) | 2008-08-05 | 2013-07-30 | Biomimedica, Inc. | Polyurethane-grafted hydrogels |
US8512338B2 (en) | 2009-04-07 | 2013-08-20 | Illuminoss Medical, Inc. | Photodynamic bone stabilization systems and methods for reinforcing bone |
RU2491960C2 (en) * | 2008-07-08 | 2013-09-10 | Истоселль, С.Л. | Three-dimensional matrixes from structured porous monetite for tissue engineering and bone regeneration and method of their obtaining |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
WO2013169366A1 (en) | 2012-05-11 | 2013-11-14 | Rti Biologics, Inc. | Xenograft soft tissue implants and methods of making and using |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
US8623030B2 (en) | 2001-08-28 | 2014-01-07 | Bonutti Skeletal Innovations Llc | Robotic arthroplasty system including navigation |
US8642061B2 (en) | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
US8679190B2 (en) | 2004-10-05 | 2014-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogel arthroplasty device |
US8684965B2 (en) | 2010-06-21 | 2014-04-01 | Illuminoss Medical, Inc. | Photodynamic bone stabilization and drug delivery systems |
US8690874B2 (en) | 2000-12-22 | 2014-04-08 | Zimmer Orthobiologics, Inc. | Composition and process for bone growth and repair |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
US20140121772A1 (en) * | 2012-10-25 | 2014-05-01 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US8734525B2 (en) | 2003-12-31 | 2014-05-27 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized cancellous bone |
US8742072B2 (en) | 2006-12-21 | 2014-06-03 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US8783470B2 (en) | 2009-03-06 | 2014-07-22 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US20140309747A1 (en) * | 2011-12-12 | 2014-10-16 | Solana Surgical, Llc | Fusion Implant |
US8870954B2 (en) | 2008-09-09 | 2014-10-28 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
US8870965B2 (en) | 2009-08-19 | 2014-10-28 | Illuminoss Medical, Inc. | Devices and methods for bone alignment, stabilization and distraction |
US8883915B2 (en) | 2008-07-07 | 2014-11-11 | Biomimedica, Inc. | Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same |
US8911759B2 (en) | 2005-11-01 | 2014-12-16 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US8926622B2 (en) | 2012-04-03 | 2015-01-06 | Warsaw Orthopedic, Inc. | Bone delivery systems including holding and filling devices and methods |
US8936644B2 (en) | 2011-07-19 | 2015-01-20 | Illuminoss Medical, Inc. | Systems and methods for joint stabilization |
US8939977B2 (en) | 2012-07-10 | 2015-01-27 | Illuminoss Medical, Inc. | Systems and methods for separating bone fixation devices from introducer |
US8992628B2 (en) | 2012-01-20 | 2015-03-31 | Warsaw Orthopedic, Inc. | Bone delivery system |
WO2015054547A1 (en) * | 2013-10-09 | 2015-04-16 | Lifenet Health | Compressed bone composition and methods of use thereof |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
US9034356B2 (en) | 2006-01-19 | 2015-05-19 | Warsaw Orthopedic, Inc. | Porous osteoimplant |
US9034052B2 (en) | 2013-01-14 | 2015-05-19 | Warsaw Orthopedic, Inc. | Delivery systems containing bioactive materials |
RU2557893C1 (en) * | 2014-04-10 | 2015-07-27 | Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "ЦИТО им. Н.Н. Приорова" Минздрава России) | Method for two-staged surgical treatment of spinal deformity with using autopreserved resected rib autograft and dry vertical halotraction |
US9107751B2 (en) | 2002-12-12 | 2015-08-18 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
US9114024B2 (en) | 2011-11-21 | 2015-08-25 | Biomimedica, Inc. | Systems, devices, and methods for anchoring orthopaedic implants to bone |
US9119732B2 (en) | 2013-03-15 | 2015-09-01 | Orthocision, Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US9125902B2 (en) | 2010-01-28 | 2015-09-08 | Warsaw Orthopedic, Inc. | Methods for treating an intervertebral disc using local analgesics |
US9144442B2 (en) | 2011-07-19 | 2015-09-29 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US9179959B2 (en) | 2010-12-22 | 2015-11-10 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US9198758B2 (en) | 2012-01-26 | 2015-12-01 | Warsaw Orthopedic, Inc. | Delivery systems |
US9265609B2 (en) | 2013-01-08 | 2016-02-23 | Warsaw Orthopedic, Inc. | Osteograft implant |
US9283013B2 (en) | 2013-03-14 | 2016-03-15 | Warsaw Orthopedic, Inc. | Filling systems for bone delivery devices |
US9333082B2 (en) | 2007-07-10 | 2016-05-10 | Warsaw Orthopedic, Inc. | Delivery system attachment |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US9364583B2 (en) | 2014-04-25 | 2016-06-14 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized bone implant |
US9427289B2 (en) | 2007-10-31 | 2016-08-30 | Illuminoss Medical, Inc. | Light source |
US9486500B2 (en) | 2010-01-28 | 2016-11-08 | Warsaw Orthopedic, Inc. | Osteoimplant and methods for making |
US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
US9556243B2 (en) | 2013-03-15 | 2017-01-31 | Biomet Biologies, LLC | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US9642891B2 (en) | 2006-06-30 | 2017-05-09 | Biomimetic Therapeutics, Llc | Compositions and methods for treating rotator cuff injuries |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US9655994B2 (en) | 2012-07-25 | 2017-05-23 | William F. McKay | Delivery systems |
US9687281B2 (en) | 2012-12-20 | 2017-06-27 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
US9701728B2 (en) | 2008-02-27 | 2017-07-11 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
WO2017147117A1 (en) | 2016-02-24 | 2017-08-31 | Warsaw Orthopedic, Inc. | Spinal implant system and method |
US9775862B2 (en) | 2012-01-30 | 2017-10-03 | Warsaw Orthopedic, Inc. | Modification of reactivity of bone constructs |
WO2017201259A1 (en) | 2016-05-18 | 2017-11-23 | Rti Surgical, Inc. | Osteoinductive nanofiber scaffold for bone regeneration |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US9897589B2 (en) | 2002-05-24 | 2018-02-20 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US10006705B2 (en) | 2015-02-09 | 2018-06-26 | Warsaw Orthopedic, Inc. | Methods for treating tissue materials |
US10064726B1 (en) | 2017-04-18 | 2018-09-04 | Warsaw Orthopedic, Inc. | 3D printing of mesh implants for bone delivery |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US20190000628A1 (en) * | 2011-02-28 | 2019-01-03 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US10457803B2 (en) | 2008-07-07 | 2019-10-29 | Hyalex Orthopaedics, Inc. | Orthopedic implants having gradient polymer alloys |
EP3563883A1 (en) | 2007-11-09 | 2019-11-06 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US10576130B2 (en) | 2013-03-15 | 2020-03-03 | Biomet Manufacturing, Llc | Treatment of collagen defects using protein solutions |
US10792392B2 (en) | 2018-07-17 | 2020-10-06 | Hyalex Orthopedics, Inc. | Ionic polymer compositions |
US10970789B2 (en) | 2018-01-23 | 2021-04-06 | Full Circle Innovation Llc | Systems and methods for facilitating insurance coverage |
US11015016B2 (en) | 2011-10-03 | 2021-05-25 | Hyalex Orthopaedics, Inc. | Polymeric adhesive for anchoring compliant materials to another surface |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US11071572B2 (en) | 2018-06-27 | 2021-07-27 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US11077228B2 (en) | 2015-08-10 | 2021-08-03 | Hyalex Orthopaedics, Inc. | Interpenetrating polymer networks |
US11147567B2 (en) | 2018-02-28 | 2021-10-19 | Joint Restoration Foundation, Inc. | Methods and devices for restoration of a bone surface |
US20220330995A1 (en) * | 2021-04-15 | 2022-10-20 | Jeremy M. Gililland | Knee sizing tool and systems and methods for use in total knee replacement procedure |
US11660196B2 (en) | 2017-04-21 | 2023-05-30 | Warsaw Orthopedic, Inc. | 3-D printing of bone grafts |
Families Citing this family (219)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7019192B2 (en) * | 1998-02-27 | 2006-03-28 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US6998135B1 (en) * | 1998-02-27 | 2006-02-14 | Musculoskeletal Transplant Foundation | Demineralized corticocancellous bone sheet |
US6293970B1 (en) | 1998-06-30 | 2001-09-25 | Lifenet | Plasticized bone and soft tissue grafts and methods of making and using same |
US8563232B2 (en) | 2000-09-12 | 2013-10-22 | Lifenet Health | Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced |
US20100030340A1 (en) * | 1998-06-30 | 2010-02-04 | Wolfinbarger Jr Lloyd | Plasticized Grafts and Methods of Making and Using Same |
US20080077251A1 (en) * | 1999-06-07 | 2008-03-27 | Chen Silvia S | Cleaning and devitalization of cartilage |
US20030114936A1 (en) * | 1998-10-12 | 2003-06-19 | Therics, Inc. | Complex three-dimensional composite scaffold resistant to delimination |
US6025538A (en) * | 1998-11-20 | 2000-02-15 | Musculoskeletal Transplant Foundation | Compound bone structure fabricated from allograft tissue |
US6383519B1 (en) * | 1999-01-26 | 2002-05-07 | Vita Special Purpose Corporation | Inorganic shaped bodies and methods for their production and use |
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
US6241770B1 (en) * | 1999-03-05 | 2001-06-05 | Gary K. Michelson | Interbody spinal fusion implant having an anatomically conformed trailing end |
WO2000054821A1 (en) * | 1999-03-16 | 2000-09-21 | Regeneration Technologies, Inc. | Molded implants for orthopedic applications |
US6767928B1 (en) * | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
US6485517B1 (en) | 1999-05-05 | 2002-11-26 | Gary K. Michelson | Nested interbody spinal fusion implants |
US6458162B1 (en) | 1999-08-13 | 2002-10-01 | Vita Special Purpose Corporation | Composite shaped bodies and methods for their production and use |
JP2003507124A (en) | 1999-08-20 | 2003-02-25 | メッツ−スタヴェンハーゲン,ペーター | Spine segment |
US6830763B2 (en) * | 1999-09-03 | 2004-12-14 | Lifenet | Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby |
US20050059953A1 (en) | 1999-09-03 | 2005-03-17 | Lifenet | Apparatus for demineralizing osteoinductive bone |
US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
US20010032017A1 (en) | 1999-12-30 | 2001-10-18 | Alfaro Arthur A. | Intervertebral implants |
AU4554101A (en) * | 2000-03-10 | 2001-09-24 | Sdgi Holdings Inc | Synthetic reinforced interbody fusion implants |
US7462195B1 (en) | 2000-04-19 | 2008-12-09 | Warsaw Orthopedic, Inc. | Artificial lumbar interbody spinal implant having an asymmetrical leading end |
US6350283B1 (en) | 2000-04-19 | 2002-02-26 | Gary K. Michelson | Bone hemi-lumbar interbody spinal implant having an asymmetrical leading end and method of installation thereof |
US20020111680A1 (en) * | 2000-06-13 | 2002-08-15 | Michelson Gary K. | Ratcheted bone dowel |
WO2001095837A1 (en) * | 2000-06-13 | 2001-12-20 | Michelson Gary K | Manufactured major long bone ring implant shaped to conform to a prepared intervertebral implantation space |
BR0112109A (en) * | 2000-06-29 | 2007-05-29 | Biosyntech Canada Inc | composition and method for the correction and regeneration of cartilage and other tissues |
US6332779B1 (en) | 2000-07-03 | 2001-12-25 | Osteotech, Inc. | Method of hard tissue repair |
US6863694B1 (en) | 2000-07-03 | 2005-03-08 | Osteotech, Inc. | Osteogenic implants derived from bone |
EP1296726B1 (en) * | 2000-07-03 | 2004-02-04 | Osteotech, Inc. | Osteogenic implants derived from bone |
US7001551B2 (en) * | 2000-07-13 | 2006-02-21 | Allograft Research Technologies, Inc. | Method of forming a composite bone material implant |
US9387094B2 (en) * | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
CA2416481C (en) * | 2000-07-19 | 2011-02-15 | Osteotech, Inc. | Osteoimplant and method of making same |
US6739112B1 (en) * | 2000-08-21 | 2004-05-25 | Nu Vasive, Inc. | Bone allograft packaging system |
US20050064041A1 (en) * | 2000-09-05 | 2005-03-24 | Lifenet | Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby |
EP1352665B1 (en) | 2000-09-19 | 2008-12-03 | Eduardo Anitua Aldecoa | Method for surface treatment of implants or prosthesis made of titanium |
JP4472925B2 (en) * | 2000-10-11 | 2010-06-02 | メイスン、マイケル・ディ | Spinal fixation device that does not require bone grafting |
CA2425556C (en) * | 2000-10-13 | 2011-12-06 | Osteotech, Inc. | Volume maintaining osteoinductive/oesteoconductive compositions |
US20030120274A1 (en) * | 2000-10-20 | 2003-06-26 | Morris John W. | Implant retaining device |
ES2319506T3 (en) * | 2000-10-24 | 2009-05-08 | Warsaw Orthopedic, Inc. | METHODS AND DEVICES OF VERTEBRAL FUSION. |
AU2002225831A1 (en) | 2000-11-03 | 2002-05-15 | Osteotech, Inc. | Spinal intervertebral implant and method of making |
US6692498B1 (en) * | 2000-11-27 | 2004-02-17 | Linvatec Corporation | Bioabsorbable, osteopromoting fixation plate |
US7323193B2 (en) | 2001-12-14 | 2008-01-29 | Osteotech, Inc. | Method of making demineralized bone particles |
US7931692B2 (en) | 2001-02-14 | 2011-04-26 | Osteotech, Inc. | Implant derived from bone |
US20020120335A1 (en) * | 2001-02-28 | 2002-08-29 | Angelucci Christopher M. | Laminoplasty implants and methods of use |
IL141813A (en) * | 2001-03-05 | 2010-04-15 | Hadasit Med Res Service | Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders |
US6749636B2 (en) * | 2001-04-02 | 2004-06-15 | Gary K. Michelson | Contoured spinal fusion implants made of bone or a bone composite material |
US6890355B2 (en) * | 2001-04-02 | 2005-05-10 | Gary K. Michelson | Artificial contoured spinal fusion implants made of a material other than bone |
US6989031B2 (en) * | 2001-04-02 | 2006-01-24 | Sdgi Holdings, Inc. | Hemi-interbody spinal implant manufactured from a major long bone ring or a bone composite |
CA2442855A1 (en) * | 2001-04-12 | 2002-10-24 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
DE10126085A1 (en) * | 2001-05-29 | 2002-12-05 | Tutogen Medical Gmbh | bone implant |
US7618937B2 (en) * | 2001-07-20 | 2009-11-17 | Northwestern University | Peptidomimetic polymers for antifouling surfaces |
US8815793B2 (en) * | 2001-07-20 | 2014-08-26 | Northwestern University | Polymeric compositions and related methods of use |
US7858679B2 (en) * | 2001-07-20 | 2010-12-28 | Northwestern University | Polymeric compositions and related methods of use |
WO2003013623A1 (en) * | 2001-08-10 | 2003-02-20 | Osteotech, Inc. | Bone plating system and method of use |
US20030065397A1 (en) * | 2001-08-27 | 2003-04-03 | Hanssen Arlen D. | Prosthetic implant support structure |
US20040162619A1 (en) | 2001-08-27 | 2004-08-19 | Zimmer Technology, Inc. | Tibial augments for use with knee joint prostheses, method of implanting the tibial augment, and associated tools |
US7892288B2 (en) | 2001-08-27 | 2011-02-22 | Zimmer Technology, Inc. | Femoral augments for use with knee joint prosthesis |
US6635087B2 (en) | 2001-08-29 | 2003-10-21 | Christopher M. Angelucci | Laminoplasty implants and methods of use |
KR20040047746A (en) | 2001-10-12 | 2004-06-05 | 오스테오테크, 인코포레이티드 | Improved bone graft |
US20030139812A1 (en) * | 2001-11-09 | 2003-07-24 | Javier Garcia | Spinal implant |
US6855167B2 (en) | 2001-12-05 | 2005-02-15 | Osteotech, Inc. | Spinal intervertebral implant, interconnections for such implant and processes for making |
US7205337B2 (en) * | 2001-12-21 | 2007-04-17 | Isotis Orthobiologics, Inc. | End-capped polymers and compositions containing such compounds |
EP1456278B1 (en) * | 2001-12-21 | 2006-03-08 | IsoTis Orthobiologics, Inc. | Compositions containing end-capped polyalkylene glycols |
BR0307033A (en) * | 2002-01-22 | 2004-12-07 | Pfizer | 3- (imidazolyl) -2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases |
EP1344538A1 (en) * | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
EP1369095A3 (en) | 2002-06-04 | 2004-01-14 | MTF MediTech Franken GmbH | Method and device for moistening a medical implant or graft |
DE60228423D1 (en) | 2002-06-04 | 2008-10-02 | Mtf Meditech Franken Gmbh | Method and device for moistening non-biological medical implant materials |
WO2003103737A1 (en) * | 2002-06-10 | 2003-12-18 | Wool Research Organisaton Of New Zealand (Inc) | Orthopaedic materials derived from keratin |
US7166133B2 (en) * | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
US20080171012A1 (en) * | 2007-01-11 | 2008-07-17 | Phillip Messersmith | Fouling Resistant Coatings and Methods of Making Same |
US8911831B2 (en) * | 2002-07-19 | 2014-12-16 | Northwestern University | Surface independent, surface-modifying, multifunctional coatings and applications thereof |
AU2002950443A0 (en) * | 2002-07-26 | 2002-09-12 | Graeme Brazenor Pty Limited | Spinal implant |
EP1528938A2 (en) * | 2002-08-12 | 2005-05-11 | Osteotech, Inc. | Synthesis of a bone-polymer composite material |
AU2003277325A1 (en) * | 2002-10-08 | 2004-05-04 | Osteotech, Inc. | Coupling agents for orthopedic biomaterials |
US7323011B2 (en) | 2002-10-18 | 2008-01-29 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft cervical fusion block |
US7582309B2 (en) * | 2002-11-15 | 2009-09-01 | Etex Corporation | Cohesive demineralized bone compositions |
EP1572258A1 (en) * | 2002-11-25 | 2005-09-14 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Organic-inorganic nanocomposite coatings for implant materials and methods of preparation thereof |
US6761739B2 (en) | 2002-11-25 | 2004-07-13 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft spacer |
KR20050088380A (en) * | 2002-12-12 | 2005-09-05 | 오스테오테크, 인코포레이티드 | Formable and settable polymer bone composite and method of production thereof |
US7192447B2 (en) | 2002-12-19 | 2007-03-20 | Synthes (Usa) | Intervertebral implant |
US7985414B2 (en) * | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
ES2541909T3 (en) | 2003-02-04 | 2015-07-28 | Warsaw Orthopedic, Inc. | Osteoimplant polyurethanes |
US7648509B2 (en) | 2003-03-10 | 2010-01-19 | Ilion Medical Llc | Sacroiliac joint immobilization |
US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
WO2004098457A1 (en) * | 2003-04-30 | 2004-11-18 | Therics, Inc. | Bone void filler and method of manufacture |
US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
AU2004247143B2 (en) * | 2003-06-11 | 2010-09-23 | Warsaw Orthopedic, Inc. | Osteoimplants and methods for their manufacture |
US20050020506A1 (en) * | 2003-07-25 | 2005-01-27 | Drapeau Susan J. | Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use |
US20060229627A1 (en) * | 2004-10-29 | 2006-10-12 | Hunt Margaret M | Variable angle spinal surgery instrument |
US7806932B2 (en) | 2003-08-01 | 2010-10-05 | Zimmer Spine, Inc. | Spinal implant |
US7169405B2 (en) * | 2003-08-06 | 2007-01-30 | Warsaw Orthopedic, Inc. | Methods and devices for the treatment of intervertebral discs |
US7335381B2 (en) * | 2003-10-02 | 2008-02-26 | Losec, Inc | Transplantable particulate bone composition having high osteoinductive capacity and methods for making and using same |
US20050085922A1 (en) * | 2003-10-17 | 2005-04-21 | Shappley Ben R. | Shaped filler for implantation into a bone void and methods of manufacture and use thereof |
US8333985B2 (en) | 2004-01-27 | 2012-12-18 | Warsaw Orthopedic, Inc. | Non-glycerol stabilized bone graft |
US7189263B2 (en) | 2004-02-03 | 2007-03-13 | Vita Special Purpose Corporation | Biocompatible bone graft material |
US20050177245A1 (en) * | 2004-02-05 | 2005-08-11 | Leatherbury Neil C. | Absorbable orthopedic implants |
CA2575740A1 (en) | 2004-03-24 | 2005-10-13 | Doctor's Research Group, Inc. | Methods of performing medical procedures that promote bone growth, methods of making compositions that promote bone growth, and apparatus for use in such methods |
US20070190101A1 (en) * | 2004-03-31 | 2007-08-16 | Chunlin Yang | Flowable bone grafts |
US7942913B2 (en) | 2004-04-08 | 2011-05-17 | Ebi, Llc | Bone fixation device |
US8163030B2 (en) * | 2004-05-06 | 2012-04-24 | Degradable Solutions Ag | Biocompatible bone implant compositions and methods for repairing a bone defect |
WO2005110437A2 (en) * | 2004-05-10 | 2005-11-24 | Therics, Inc. | Implantable biostructure comprising an osteoconductive member and an osteoinductive material |
WO2005114322A2 (en) | 2004-05-12 | 2005-12-01 | Massachusetts Institute Of Technology | Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like |
US7887587B2 (en) | 2004-06-04 | 2011-02-15 | Synthes Usa, Llc | Soft tissue spacer |
KR100750190B1 (en) | 2004-06-16 | 2007-08-31 | 요업기술원 | Effective bone filler and manufacturing methods thereof |
US9220595B2 (en) | 2004-06-23 | 2015-12-29 | Orthovita, Inc. | Shapeable bone graft substitute and instruments for delivery thereof |
WO2006029270A1 (en) * | 2004-09-07 | 2006-03-16 | Smith & Nephew, Inc. | Methods and devices for sterile field transfer |
US7670384B2 (en) * | 2004-10-14 | 2010-03-02 | Biomet Manufacturing Corp. | Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone |
US20060083769A1 (en) * | 2004-10-14 | 2006-04-20 | Mukesh Kumar | Method and apparatus for preparing bone |
EP1833452A1 (en) | 2004-11-23 | 2007-09-19 | Smith and Nephew, Inc. | Composite mixer |
JP2008521560A (en) * | 2004-11-30 | 2008-06-26 | オステオバイオロジクス・インコーポレーテッド | Implant and its delivery system for treating joint surface defects |
US7527640B2 (en) | 2004-12-22 | 2009-05-05 | Ebi, Llc | Bone fixation system |
CN101141934B (en) * | 2005-01-14 | 2010-11-24 | 骨骼技术股份有限公司 | Expandable osteoimplant |
US20060216321A1 (en) * | 2005-03-24 | 2006-09-28 | Sdgi Holdings, Inc. | Solvent based processing technologies for making tissue/polymer composites |
CA2604622A1 (en) | 2005-04-15 | 2006-10-26 | Musculoskeletal Transplant Foundation | Vertebral disc repair |
US7857853B2 (en) * | 2005-04-29 | 2010-12-28 | Sdgi Holdings, Inc | Synthetic loadbearing collagen-mineral composites useful for spinal implants, and methods of manufacture |
US7955364B2 (en) | 2005-09-21 | 2011-06-07 | Ebi, Llc | Variable angle bone fixation assembly |
WO2007056671A1 (en) | 2005-11-02 | 2007-05-18 | Osteotech, Inc. | Hemostatic bone graft |
US20100040668A1 (en) * | 2006-01-12 | 2010-02-18 | Rutgers, The State University Of New Jersey | Biomimetic Hydroxyapatite Composite Materials and Methods for the Preparation Thereof |
US8287914B2 (en) * | 2006-01-12 | 2012-10-16 | Rutgers, The State University Of New Jersey | Biomimetic hydroxyapatite synthesis |
US7749555B2 (en) * | 2006-01-25 | 2010-07-06 | Medtronic, Inc | Modification of chemical forces of bone constructs |
US7824703B2 (en) * | 2006-02-01 | 2010-11-02 | Warsaw Orthopedics, Inc. | Medical implants with reservoir(s), and materials preparable from same |
US7732539B2 (en) * | 2006-02-16 | 2010-06-08 | National Science Foundation | Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives |
US8673019B2 (en) * | 2006-04-13 | 2014-03-18 | Warsaw Orthopedic, Inc. | Use of anti-inflammatory compounds with allograft tissue implantation |
US7771414B2 (en) * | 2006-04-24 | 2010-08-10 | Warsaw Orthopedic, Inc. | Controlled release devices for therapeutic treatments of spinal discs |
US8642060B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for osteal growth |
US8642059B2 (en) * | 2006-04-24 | 2014-02-04 | Warsaw Orthopedic, Inc. | Controlled release systems and methods for intervertebral discs |
US7879027B2 (en) * | 2006-04-24 | 2011-02-01 | Warsaw Orthopedic, Inc. | Controlled release devices for fusion of osteal structures |
US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US7771741B2 (en) | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
US20080262633A1 (en) * | 2006-05-08 | 2008-10-23 | Williams Michelle Leroux | Cancellous bone treated with collagenase and essentially free of blood cells |
AU2007250080B2 (en) | 2006-05-08 | 2011-08-18 | Nuvasive, Inc. | Cancellous bone treated with collagenase and essentially free of blood cells |
AU2007265379B9 (en) * | 2006-06-29 | 2014-05-29 | Orthovita, Inc. | Bioactive bone graft substitute |
WO2008013763A2 (en) | 2006-07-25 | 2008-01-31 | Musculoskeletal Transplant Foundation | Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation |
US20080033572A1 (en) * | 2006-08-03 | 2008-02-07 | Ebi L.P. | Bone graft composites and methods of treating bone defects |
WO2008091386A2 (en) * | 2006-08-04 | 2008-07-31 | Northwestern University | Biomimetic modular adhesive complex: material, methods and applications therefore |
WO2008019352A1 (en) | 2006-08-04 | 2008-02-14 | Nerites Corporation | Biomimetic compounds and synthetic methods therefor |
US9066994B2 (en) * | 2006-08-31 | 2015-06-30 | Warsaw Orthopedic, Inc. | Demineralized cancellous strip DBM graft |
ZA200900932B (en) | 2006-09-25 | 2010-06-30 | Orthovita Inc | Bioactive load-bearing composites |
US8388626B2 (en) * | 2006-11-08 | 2013-03-05 | Warsaw Orthopedic, Inc. | Methods of employing calcium phosphate cement compositions and osteoinductive proteins to effect vertebrae interbody fusion absent an interbody device |
AU2008216371B2 (en) | 2007-02-12 | 2014-04-10 | Warsaw Orthopedic, Inc. | Joint revision implant |
US8673286B2 (en) | 2007-04-09 | 2014-03-18 | Northwestern University | DOPA-functionalized, branched, poly(aklylene oxide) adhesives |
US8383092B2 (en) * | 2007-02-16 | 2013-02-26 | Knc Ner Acquisition Sub, Inc. | Bioadhesive constructs |
US20080206299A1 (en) * | 2007-02-27 | 2008-08-28 | Shimp Lawrence A | Method for Recovering Minerals From Bone and Use of Same |
US20080230094A1 (en) * | 2007-03-23 | 2008-09-25 | Buckman Laboratories International, Inc. | Method to inhibit growth of microorganisms in aqueous systems and on substrates using persulfate and a bromide |
US7658940B2 (en) * | 2007-03-30 | 2010-02-09 | Skeletal Kinetics, Llc | Calcium phosphate cements comprising autologous bone |
US20090018659A1 (en) * | 2007-07-10 | 2009-01-15 | Malinin Theodore I | Invertebral spinal implant and method of making the same |
US20100268339A1 (en) * | 2007-07-10 | 2010-10-21 | Malinin Theodore I | Intervertebral Spinal Implant and Method of Making the Same |
US9125743B2 (en) * | 2007-07-16 | 2015-09-08 | Lifenet Health | Devitalization and recellularization of cartilage |
US9744043B2 (en) * | 2007-07-16 | 2017-08-29 | Lifenet Health | Crafting of cartilage |
US20090024174A1 (en) | 2007-07-17 | 2009-01-22 | Stark John G | Bone screws and particular applications to sacroiliac joint fusion |
US8512342B2 (en) * | 2007-08-11 | 2013-08-20 | Thomas L. Meredith | Portable bone grinder |
WO2009026387A1 (en) * | 2007-08-20 | 2009-02-26 | Vanderbilt University | Poly(ester urethane) urea foams with enhanced mechanical and biological properties |
KR100916722B1 (en) * | 2007-10-13 | 2009-09-14 | 민병호 | Artificial tooth operating method using mussel bond |
US9056150B2 (en) | 2007-12-04 | 2015-06-16 | Warsaw Orthopedic, Inc. | Compositions for treating bone defects |
EP2231210A4 (en) * | 2007-12-12 | 2013-01-23 | Warsaw Orthopedic Inc | Bone/collagen composites and uses thereof |
US8740912B2 (en) | 2008-02-27 | 2014-06-03 | Ilion Medical Llc | Tools for performing less invasive orthopedic joint procedures |
US8840913B2 (en) | 2008-03-27 | 2014-09-23 | Warsaw Orthopedic, Inc. | Malleable multi-component implants and materials therefor |
US20100068171A1 (en) * | 2008-05-27 | 2010-03-18 | Vanderbilt University | Injectable bone/polymer composite bone void fillers |
KR20110086045A (en) | 2008-10-24 | 2011-07-27 | 오스테오테크, 인코포레이티드 | Compositions and methods for promoting bone formation |
WO2012134540A2 (en) | 2010-10-22 | 2012-10-04 | Vanderbilt University | Injectable synthetic pur composite |
US9333276B2 (en) * | 2008-10-30 | 2016-05-10 | Vanderbilt University | Bone/polyurethane composites and methods thereof |
US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
CN102300594B (en) * | 2008-12-13 | 2014-09-17 | 先进生物制品有限责任公司 | Bioactive Grafts And Composites |
US20100168798A1 (en) | 2008-12-30 | 2010-07-01 | Clineff Theodore D | Bioactive composites of polymer and glass and method for making same |
US9821033B2 (en) * | 2009-02-27 | 2017-11-21 | Kieran Murphy Llc | Modulating bone growth in treating scoliosis |
USD773047S1 (en) * | 2009-07-20 | 2016-11-29 | Teknimed S.A. | Bone filler particle |
EP2461771A4 (en) * | 2009-08-07 | 2014-01-29 | Ebi Llc | Toroid-shaped spinal disc |
US20110035010A1 (en) * | 2009-08-07 | 2011-02-10 | Ebi, Llc | Toroid-shaped spinal disc |
US8821504B2 (en) | 2009-11-20 | 2014-09-02 | Zimmer Knee Creations, Inc. | Method for treating joint pain and associated instruments |
WO2011063250A1 (en) * | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Implantable devices for subchondral treatment of joint pain |
CN102740789A (en) | 2009-11-20 | 2012-10-17 | 膝部创造物有限责任公司 | Instruments for targeting a joint defect |
WO2011063281A1 (en) | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Navigation and positioning instruments for joint repair |
US8801800B2 (en) | 2009-11-20 | 2014-08-12 | Zimmer Knee Creations, Inc. | Bone-derived implantable devices and tool for subchondral treatment of joint pain |
KR20120101079A (en) | 2009-11-20 | 2012-09-12 | 니 크리에이션스, 엘엘씨 | Instruments for a variable angle approach to a joint |
US8951261B2 (en) | 2009-11-20 | 2015-02-10 | Zimmer Knee Creations, Inc. | Subchondral treatment of joint pain |
AU2010321743A1 (en) | 2009-11-20 | 2012-07-12 | Knee Creations, Llc | Coordinate mapping system for joint treatment |
US8608802B2 (en) | 2009-11-20 | 2013-12-17 | Zimmer Knee Creations, Inc. | Implantable devices for subchondral treatment of joint pain |
US20110130465A1 (en) * | 2009-12-01 | 2011-06-02 | Nerites Corporation | Coatings for prevention of biofilms |
US20140286911A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
AU2010328427B2 (en) | 2009-12-13 | 2014-06-05 | Advanced Biologics, Inc. | Bioactive grafts and composites |
AU2011293202B2 (en) * | 2010-08-26 | 2017-01-19 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating bone defects |
WO2012064821A2 (en) | 2010-11-09 | 2012-05-18 | Knc Ner Acquisition Sub, Inc. | Adhesive compounds and methods use for hernia repair |
US8673014B2 (en) | 2011-04-01 | 2014-03-18 | Kls-Martin, L.P. | Method of cranial repair and cranial repair implant molding device |
US20140236312A1 (en) * | 2011-05-10 | 2014-08-21 | Mark R. Appleford | Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications |
DE102011112249A1 (en) * | 2011-09-01 | 2013-03-07 | Heinrich-Heine-Universität Düsseldorf | Dental filler mix for filling root canals |
US9770340B2 (en) | 2011-09-16 | 2017-09-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US8961606B2 (en) | 2011-09-16 | 2015-02-24 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US9539109B2 (en) | 2011-09-16 | 2017-01-10 | Globus Medical, Inc. | Low profile plate |
US10881526B2 (en) | 2011-09-16 | 2021-01-05 | Globus Medical, Inc. | Low profile plate |
US9681959B2 (en) | 2011-09-16 | 2017-06-20 | Globus Medical, Inc. | Low profile plate |
US9204975B2 (en) | 2011-09-16 | 2015-12-08 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US9149365B2 (en) | 2013-03-05 | 2015-10-06 | Globus Medical, Inc. | Low profile plate |
US9848994B2 (en) | 2011-09-16 | 2017-12-26 | Globus Medical, Inc. | Low profile plate |
US9237957B2 (en) | 2011-09-16 | 2016-01-19 | Globus Medical, Inc. | Low profile plate |
US9398960B2 (en) | 2011-09-16 | 2016-07-26 | Globus Medical, Inc. | Multi-piece intervertebral implants |
US10245155B2 (en) | 2011-09-16 | 2019-04-02 | Globus Medical, Inc. | Low profile plate |
WO2013070907A1 (en) | 2011-11-08 | 2013-05-16 | Tufts University | A silk-based scaffold platform for engineering tissue constructs |
US8920511B2 (en) | 2011-11-17 | 2014-12-30 | Allosource | Multi-piece machine graft systems and methods |
US10780197B1 (en) | 2012-10-29 | 2020-09-22 | Nuvasive, Inc. | Malleable, cryopreserved osteogenic compositions with viable cells |
EP2958523B1 (en) | 2013-02-22 | 2020-04-22 | AlloSource | Cartilage mosaic compositions and methods |
US9168140B2 (en) | 2013-03-15 | 2015-10-27 | Allosource | Perforated osteochondral allograft compositions |
CN104606713B (en) * | 2015-01-04 | 2017-04-19 | 浙江大学 | Three-dimensional parallel collagenous fiber-silk bracket as well as preparation method and application thereof |
US10238507B2 (en) | 2015-01-12 | 2019-03-26 | Surgentec, Llc | Bone graft delivery system and method for using same |
US10610366B2 (en) | 2015-01-29 | 2020-04-07 | Theracell, Inc. | Demineralized bone fiber composition for use in minimally invasive surgery |
RU2597786C2 (en) * | 2015-02-10 | 2016-09-20 | Общество с ограниченной ответственностью "НекстГен" | Method for creating personalized gene-activated implant for bone tissue regeneration |
US10779960B2 (en) * | 2015-02-27 | 2020-09-22 | In2Bones Usa, Llc | Engineered sterile cartilage allograft implant plug with sterile, specific instrument kit(s) |
ES2579305B1 (en) * | 2016-04-29 | 2017-03-24 | Optimus 3D S.L. | PROCEDURE FOR OBTAINING AN ACTIVE IMPLANT FOR USE IN THE REGENERATION OF BONE MASS AND CORRESPONDING IMPLANT OBTAINED |
WO2018071053A1 (en) * | 2016-10-14 | 2018-04-19 | Allosource | Consistent calcium content bone allograft systems and methods |
JP6916290B2 (en) | 2017-01-20 | 2021-08-11 | バイオメット マニュファクチャリング,リミティド ライアビリティ カンパニー | Modular augmentation component |
US11452608B2 (en) | 2017-04-05 | 2022-09-27 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
US10376385B2 (en) | 2017-04-05 | 2019-08-13 | Globus Medical, Inc. | Decoupled spacer and plate and method of installing the same |
KR102632931B1 (en) | 2017-06-30 | 2024-02-05 | 알로소스 | Cellular bone grafts and methods of manufacture and use |
EP3656785B1 (en) * | 2017-07-18 | 2024-09-11 | POSCO Co., Ltd | Antimicrobial adhesive protein, antimicrobial nanoparticle, antimicrobial composition comprising same nanoparticle, and preparation method for same composition |
US10687828B2 (en) | 2018-04-13 | 2020-06-23 | Surgentec, Llc | Bone graft delivery system and method for using same |
US11116647B2 (en) | 2018-04-13 | 2021-09-14 | Surgentec, Llc | Bone graft delivery system and method for using same |
CN111973797B (en) * | 2020-09-04 | 2022-06-03 | 湖南奥星生物医药股份有限公司 | Non-invasive implantation high-viscosity adhesive material for orthopedics department and preparation method and application thereof |
JP1721477S (en) * | 2021-09-13 | 2022-08-02 | Medical implants for scaffolds for optimized tissue regeneration |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2967060D1 (en) | 1979-12-18 | 1984-07-19 | Oscobal Ag | Bone replacement material and process for producing a bone replacement material |
US4637931A (en) | 1984-10-09 | 1987-01-20 | The United States Of America As Represented By The Secretary Of The Army | Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material |
US4743259A (en) | 1986-10-29 | 1988-05-10 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
US4902296A (en) | 1986-10-29 | 1990-02-20 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
CA1339083C (en) | 1987-11-13 | 1997-07-29 | Steven R. Jefferies | Bone repair material and delayed drug delivery system |
US5219576A (en) * | 1988-06-30 | 1993-06-15 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5207710A (en) | 1988-09-29 | 1993-05-04 | Collagen Corporation | Method for improving implant fixation |
US5061286A (en) * | 1989-08-18 | 1991-10-29 | Osteotech, Inc. | Osteoprosthetic implant |
US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
JPH03131263A (en) * | 1989-10-16 | 1991-06-04 | Nippon Electric Glass Co Ltd | Cement for living body |
US5314476A (en) * | 1992-02-04 | 1994-05-24 | Osteotech, Inc. | Demineralized bone particles and flowable osteogenic composition containing same |
JPH0753204A (en) * | 1993-08-18 | 1995-02-28 | S T K Ceramics Kenkyusho:Kk | Calcium phosphate-based self-hardenable composition |
US5507813A (en) * | 1993-12-09 | 1996-04-16 | Osteotech, Inc. | Shaped materials derived from elongate bone particles |
US5709683A (en) | 1995-12-19 | 1998-01-20 | Spine-Tech, Inc. | Interbody bone implant having conjoining stabilization features for bony fusion |
US5814084A (en) | 1996-01-16 | 1998-09-29 | University Of Florida Tissue Bank, Inc. | Diaphysial cortical dowel |
CA2243365C (en) | 1996-01-17 | 2006-07-25 | Michael Dowd | Process and apparatus for producing flexible sheets from demineralized, elongate, bone particles |
US5824078A (en) * | 1996-03-11 | 1998-10-20 | The Board Of Trustees Of The University Of Arkansas | Composite allograft, press, and methods |
US5868749A (en) | 1996-04-05 | 1999-02-09 | Reed; Thomas M. | Fixation devices |
JP4014698B2 (en) * | 1997-07-15 | 2007-11-28 | ペンタックス株式会社 | Method for producing porous calcium phosphate ceramics |
US5899939A (en) * | 1998-01-21 | 1999-05-04 | Osteotech, Inc. | Bone-derived implant for load-supporting applications |
US6123731A (en) | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
-
1999
- 1999-02-23 US US09/256,447 patent/US6294187B1/en not_active Expired - Lifetime
-
2000
- 2000-02-22 DE DE60027698T patent/DE60027698T2/en not_active Expired - Lifetime
- 2000-02-22 ES ES00915821T patent/ES2261191T3/en not_active Expired - Lifetime
- 2000-02-22 EP EP00915821A patent/EP1152777B1/en not_active Expired - Lifetime
- 2000-02-22 TR TR2001/02480T patent/TR200102480T2/en unknown
- 2000-02-22 JP JP2000600712A patent/JP4658331B2/en not_active Expired - Fee Related
- 2000-02-22 KR KR1020017010795A patent/KR100754814B1/en not_active IP Right Cessation
- 2000-02-22 AU AU37033/00A patent/AU758828B2/en not_active Ceased
- 2000-02-22 WO PCT/US2000/004408 patent/WO2000050102A1/en active IP Right Grant
- 2000-02-22 CA CA2363153A patent/CA2363153C/en not_active Expired - Fee Related
-
2001
- 2001-07-24 US US09/911,562 patent/US6440444B2/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294187B1 (en) * | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
Cited By (448)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7045141B2 (en) | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US20080188945A1 (en) * | 1999-02-23 | 2008-08-07 | Boyce Todd M | Shaped load-bearing osteoimplant and methods of making same |
US20070233272A1 (en) * | 1999-02-23 | 2007-10-04 | Boyce Todd M | Shaped load-bearing osteoimplant and methods of making same |
US8133421B2 (en) | 1999-02-23 | 2012-03-13 | Warsaw Orthopedic, Inc. | Methods of making shaped load-bearing osteoimplant |
US6558422B1 (en) * | 1999-03-26 | 2003-05-06 | University Of Washington | Structures having coated indentations |
US20020052654A1 (en) * | 1999-05-10 | 2002-05-02 | C.R. Bard, Inc. | Prosthetic repair fabric |
US20040003757A1 (en) * | 1999-07-14 | 2004-01-08 | Cana Lab Corporation | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface |
US7186294B2 (en) | 1999-07-14 | 2007-03-06 | Calcitec, Inc. | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US7279038B2 (en) | 1999-07-14 | 2007-10-09 | Calcitec, Inc. | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US20060011099A1 (en) * | 1999-07-14 | 2006-01-19 | Lin Jiin-Huey C | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US20050268819A1 (en) * | 1999-07-14 | 2005-12-08 | Cana Lab Corporation | Injectable calcium phosphate cements and the preparation and use thereof |
US20050271742A1 (en) * | 1999-07-14 | 2005-12-08 | Calcitec, Inc. | Injectable calcium phosphate cements and the preparation and use thereof |
US20050279256A1 (en) * | 1999-07-14 | 2005-12-22 | Lin Jiin-Huey C | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US20050274289A1 (en) * | 1999-07-14 | 2005-12-15 | Lin Jiin-Huey C | Process for affecting the setting and working time of, bioresorbable calcium phosphate cements |
US20040175320A1 (en) * | 1999-07-14 | 2004-09-09 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same |
US7066999B2 (en) | 1999-07-14 | 2006-06-27 | Calcitec, Inc. | Process for producing fast-setting, bioresorbable calcium phosphate cements |
US20050069479A1 (en) * | 1999-07-14 | 2005-03-31 | Calcitec, Inc. | Method of increasing working time of tetracalcium phosphate cement paste |
US20050076813A1 (en) * | 1999-07-14 | 2005-04-14 | Calcitec, Inc. | Process for producing fast-setting, bioresorbable calcium phosphate cements |
US7169373B2 (en) | 1999-07-14 | 2007-01-30 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same |
US20060011100A1 (en) * | 1999-07-14 | 2006-01-19 | Lin Jiin-Huey C | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US7201797B2 (en) | 1999-07-14 | 2007-04-10 | Calcitec, Inc. | Process for affecting the setting and working time of, bioresorbable calcium phosphate cements |
US7258735B2 (en) | 1999-07-14 | 2007-08-21 | Calcitec, Inc. | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US7258734B2 (en) | 1999-07-14 | 2007-08-21 | Calcitec, Inc. | Injectable calcium phosphate cements and the preparation and use thereof |
US7270705B2 (en) | 1999-07-14 | 2007-09-18 | Jiin-Huey Chern Lin | Method of increasing working time of tetracalcium phosphate cement paste |
US20050274288A1 (en) * | 1999-07-14 | 2005-12-15 | Lin Jiin-Huey C | Process for affecting the setting and working time of bioresorbable calcium phosphate cements |
US6732738B1 (en) * | 1999-09-30 | 2004-05-11 | Masashi Komeda | Method to enhance healing of sternum after sternotomy |
US9795394B2 (en) | 2000-01-14 | 2017-10-24 | Bonutti Skeletal Innovations Llc | Method for placing implant using robotic system |
US7959635B1 (en) | 2000-01-14 | 2011-06-14 | Marctec, Llc. | Limited incision total joint replacement methods |
US7749229B1 (en) | 2000-01-14 | 2010-07-06 | Marctec, Llc | Total knee arthroplasty through shortened incision |
US7806897B1 (en) | 2000-01-14 | 2010-10-05 | Marctec, Llc | Knee arthroplasty and preservation of the quadriceps mechanism |
US7828852B2 (en) | 2000-01-14 | 2010-11-09 | Marctec, Llc. | Inlaid articular implant |
US7837736B2 (en) | 2000-01-14 | 2010-11-23 | Marctec, Llc | Minimally invasive surgical systems and methods |
US7892236B1 (en) | 2000-01-14 | 2011-02-22 | Marctec, Llc | System and method for total joint replacement |
US7931690B1 (en) | 2000-01-14 | 2011-04-26 | Marctec, Llc | Method of resurfacing an articular surface of a bone |
US8784495B2 (en) | 2000-01-14 | 2014-07-22 | Bonutti Skeletal Innovations Llc | Segmental knee arthroplasty |
US7708740B1 (en) | 2000-01-14 | 2010-05-04 | Marctec, Llc | Method for total knee arthroplasty and resecting bone in situ |
US8133229B1 (en) | 2000-01-14 | 2012-03-13 | Marctec, Llc. | Knee arthroplasty method |
US8425522B2 (en) | 2000-01-14 | 2013-04-23 | Bonutti Skeletal Innovations Llc | Joint replacement method |
US9192459B2 (en) | 2000-01-14 | 2015-11-24 | Bonutti Skeletal Innovations Llc | Method of performing total knee arthroplasty |
US8632552B2 (en) | 2000-01-14 | 2014-01-21 | Bonutti Skeletal Innovations Llc | Method of preparing a femur and tibia in knee arthroplasty |
US9101443B2 (en) | 2000-01-14 | 2015-08-11 | Bonutti Skeletal Innovations Llc | Methods for robotic arthroplasty |
US6632247B2 (en) | 2000-03-22 | 2003-10-14 | Synthes (Usa) | Implants formed of coupled bone |
US7087087B2 (en) | 2000-03-22 | 2006-08-08 | Boyer Ii Michael L | Implants formed of coupled bone |
US7094282B2 (en) | 2000-07-13 | 2006-08-22 | Calcitec, Inc. | Calcium phosphate cement, use and preparation thereof |
US7214265B2 (en) | 2000-07-13 | 2007-05-08 | Calcitec, Inc. | Injectable calcium phosphate cements and the preparation and use thereof |
US20050268821A1 (en) * | 2000-07-13 | 2005-12-08 | Cana Lab Corporation | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US20050268820A1 (en) * | 2000-07-13 | 2005-12-08 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface |
US20050271740A1 (en) * | 2000-07-13 | 2005-12-08 | Cana Lab Corporation | Injectable calcium phosphate cements and the preparation and use thereof |
US20040031420A1 (en) * | 2000-07-13 | 2004-02-19 | Lin Jiin-Huey Chern | Calcium phosphate cement, use and preparation thereof |
US20050274287A1 (en) * | 2000-07-13 | 2005-12-15 | Lin Jiin-Huey C | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US20050274286A1 (en) * | 2000-07-13 | 2005-12-15 | Lin Jiin-Huey C | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US20050274282A1 (en) * | 2000-07-13 | 2005-12-15 | Lin Jiin-Huey C | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US20050271741A1 (en) * | 2000-07-13 | 2005-12-08 | Cana Lab Corporation | Injectable calcium phosphate cements and the preparation and use thereof |
US20050279252A1 (en) * | 2000-07-13 | 2005-12-22 | Cana Lab Corporation | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US7976874B2 (en) | 2000-07-13 | 2011-07-12 | Jiin-Huey Chern Lin | Injectable calcium phosphate cements and the preparation and use thereof |
US7156915B2 (en) | 2000-07-13 | 2007-01-02 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US7160382B2 (en) | 2000-07-13 | 2007-01-09 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US7204876B2 (en) | 2000-07-13 | 2007-04-17 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US7160381B2 (en) | 2000-07-13 | 2007-01-09 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US7182928B2 (en) | 2000-07-13 | 2007-02-27 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
US20030023316A1 (en) * | 2000-08-04 | 2003-01-30 | Brown Laura Jean | Hybrid biologic-synthetic bioabsorable scaffolds |
US7160333B2 (en) * | 2000-08-04 | 2007-01-09 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US20040059431A1 (en) * | 2000-08-04 | 2004-03-25 | Plouhar Pamela L. | Reinforced small intestinal submucosa |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US7799089B2 (en) | 2000-08-04 | 2010-09-21 | Depuy Orthopaedics, Inc. | Reinforced small intestinal submucosa |
US8758438B2 (en) | 2000-12-08 | 2014-06-24 | Warsaw Orthopedic, Inc. | Implant for orthopedic applications |
US20040024457A1 (en) * | 2000-12-08 | 2004-02-05 | Boyce Todd M. | Implant for orthopedic applications |
US8690874B2 (en) | 2000-12-22 | 2014-04-08 | Zimmer Orthobiologics, Inc. | Composition and process for bone growth and repair |
US6776800B2 (en) | 2001-02-28 | 2004-08-17 | Synthes (U.S.A.) | Implants formed with demineralized bone |
US8740987B2 (en) | 2001-06-04 | 2014-06-03 | Warsaw Orthopedic, Inc. | Tissue-derived mesh for orthopedic regeneration |
US20050283255A1 (en) * | 2001-06-04 | 2005-12-22 | Perry Geremakis | Tissue-derived mesh for orthopedic regeneration |
US20030033021A1 (en) * | 2001-07-16 | 2003-02-13 | Plouhar Pamela Lynn | Cartilage repair and regeneration scaffold and method |
US8337537B2 (en) | 2001-07-16 | 2012-12-25 | Depuy Products, Inc. | Device from naturally occurring biologically derived materials |
US8092529B2 (en) | 2001-07-16 | 2012-01-10 | Depuy Products, Inc. | Meniscus regeneration device |
US8025896B2 (en) | 2001-07-16 | 2011-09-27 | Depuy Products, Inc. | Porous extracellular matrix scaffold and method |
US7819918B2 (en) * | 2001-07-16 | 2010-10-26 | Depuy Products, Inc. | Implantable tissue repair device |
US8012205B2 (en) * | 2001-07-16 | 2011-09-06 | Depuy Products, Inc. | Cartilage repair and regeneration device |
US20040220574A1 (en) * | 2001-07-16 | 2004-11-04 | Pelo Mark Joseph | Device from naturally occuring biologically derived materials |
US7914808B2 (en) | 2001-07-16 | 2011-03-29 | Depuy Products, Inc. | Hybrid biologic/synthetic porous extracellular matrix scaffolds |
US8641726B2 (en) | 2001-08-28 | 2014-02-04 | Bonutti Skeletal Innovations Llc | Method for robotic arthroplasty using navigation |
US8840629B2 (en) | 2001-08-28 | 2014-09-23 | Bonutti Skeletal Innovations Llc | Robotic arthroplasty system including navigation |
US8858557B2 (en) | 2001-08-28 | 2014-10-14 | Bonutti Skeletal Innovations Llc | Method of preparing a femur and tibia in knee arthroplasty |
US9763683B2 (en) | 2001-08-28 | 2017-09-19 | Bonutti Skeletal Innovations Llc | Method for performing surgical procedures using optical cutting guides |
US8623030B2 (en) | 2001-08-28 | 2014-01-07 | Bonutti Skeletal Innovations Llc | Robotic arthroplasty system including navigation |
US8834490B2 (en) | 2001-08-28 | 2014-09-16 | Bonutti Skeletal Innovations Llc | Method for robotic arthroplasty using navigation |
US10470780B2 (en) | 2001-08-28 | 2019-11-12 | Bonutti Skeletal Innovations Llc | Systems and methods for ligament balancing in robotic surgery |
US10321918B2 (en) | 2001-08-28 | 2019-06-18 | Bonutti Skeletal Innovations Llc | Methods for robotic surgery using a cannula |
US9060797B2 (en) | 2001-08-28 | 2015-06-23 | Bonutti Skeletal Innovations Llc | Method of preparing a femur and tibia in knee arthroplasty |
US10231739B1 (en) | 2001-08-28 | 2019-03-19 | Bonutti Skeletal Innovations Llc | System and method for robotic surgery |
US20040137032A1 (en) * | 2002-03-15 | 2004-07-15 | Wang Francis W. | Combinations of calcium phosphates, bone growth factors, and pore-forming additives as osteoconductive and osteoinductive composite bone grafts |
US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
US8187477B2 (en) | 2002-05-03 | 2012-05-29 | Hanuman, Llc | Methods and apparatus for isolating platelets from blood |
US8950586B2 (en) | 2002-05-03 | 2015-02-10 | Hanuman Llc | Methods and apparatus for isolating platelets from blood |
US7837884B2 (en) | 2002-05-03 | 2010-11-23 | Hanuman, Llc | Methods and apparatus for isolating platelets from blood |
US20030216777A1 (en) * | 2002-05-16 | 2003-11-20 | Yin-Chun Tien | Method of enhancing healing of interfacial gap between bone and tendon or ligament |
US20090269388A1 (en) * | 2002-05-20 | 2009-10-29 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
US7914689B2 (en) | 2002-05-24 | 2011-03-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US9897589B2 (en) | 2002-05-24 | 2018-02-20 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8808551B2 (en) | 2002-05-24 | 2014-08-19 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US10393728B2 (en) | 2002-05-24 | 2019-08-27 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8603346B2 (en) | 2002-05-24 | 2013-12-10 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US10183042B2 (en) | 2002-05-24 | 2019-01-22 | Biomet Manufacturing, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8062534B2 (en) | 2002-05-24 | 2011-11-22 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8048321B2 (en) | 2002-05-24 | 2011-11-01 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US8163184B2 (en) | 2002-05-24 | 2012-04-24 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7780860B2 (en) | 2002-05-24 | 2010-08-24 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
US9114334B2 (en) | 2002-05-24 | 2015-08-25 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20050244239A1 (en) * | 2002-05-30 | 2005-11-03 | Shimp Lawrence A | Method and apparatus for machining a surgical implant |
US20040010314A1 (en) * | 2002-06-12 | 2004-01-15 | Pentax Corporation | Bone replacement material |
US7238209B2 (en) * | 2002-06-12 | 2007-07-03 | Pentax Corporation | Bone replacement material |
US7682392B2 (en) * | 2002-10-30 | 2010-03-23 | Depuy Spine, Inc. | Regenerative implants for stabilizing the spine and devices for attachment of said implants |
US10080661B2 (en) | 2002-12-12 | 2018-09-25 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
US9333080B2 (en) | 2002-12-12 | 2016-05-10 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
US9107751B2 (en) | 2002-12-12 | 2015-08-18 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
USRE42208E1 (en) | 2003-04-29 | 2011-03-08 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
USRE43258E1 (en) | 2003-04-29 | 2012-03-20 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US8221500B2 (en) | 2003-05-16 | 2012-07-17 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7118705B2 (en) | 2003-08-05 | 2006-10-10 | Calcitec, Inc. | Method for making a molded calcium phosphate article |
US20050101964A1 (en) * | 2003-11-07 | 2005-05-12 | Calcitec, Inc. | Spinal fusion procedure using an injectable bone substitute |
US8328876B2 (en) | 2003-12-31 | 2012-12-11 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US9415136B2 (en) | 2003-12-31 | 2016-08-16 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized cancellous bone |
US8734525B2 (en) | 2003-12-31 | 2014-05-27 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized cancellous bone |
US9034358B2 (en) | 2003-12-31 | 2015-05-19 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US20070154563A1 (en) * | 2003-12-31 | 2007-07-05 | Keyvan Behnam | Bone matrix compositions and methods |
US8012210B2 (en) | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
US20060015184A1 (en) * | 2004-01-30 | 2006-01-19 | John Winterbottom | Stacking implants for spinal fusion |
US20050186354A1 (en) * | 2004-02-19 | 2005-08-25 | Lin Jiin-Huey C. | Method for making a porous calcium phosphate article |
US20050184418A1 (en) * | 2004-02-19 | 2005-08-25 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US7163651B2 (en) | 2004-02-19 | 2007-01-16 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US7119038B2 (en) | 2004-02-19 | 2006-10-10 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US20050186449A1 (en) * | 2004-02-19 | 2005-08-25 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US20050186353A1 (en) * | 2004-02-19 | 2005-08-25 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US7097793B2 (en) | 2004-02-19 | 2006-08-29 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US7083750B2 (en) | 2004-02-19 | 2006-08-01 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US20050184417A1 (en) * | 2004-02-19 | 2005-08-25 | Cana Lab Corporation | Method for making a porous calcium phosphate article |
US20050229323A1 (en) * | 2004-04-20 | 2005-10-20 | Mills C R | Process and apparatus for treating implants comprising soft tissue |
US7648676B2 (en) | 2004-04-20 | 2010-01-19 | Rti Biologics, Inc. | Process and apparatus for treating implants comprising soft tissue |
US20060228252A1 (en) * | 2004-04-20 | 2006-10-12 | Mills C R | Process and apparatus for treating implants comprising soft tissue |
US20050244450A1 (en) * | 2004-04-28 | 2005-11-03 | Reddi A H | Heat-treated implantable bone material |
US20050244457A1 (en) * | 2004-04-28 | 2005-11-03 | Reddi A H | Irradiated implantable bone material |
US7976861B2 (en) | 2004-04-28 | 2011-07-12 | Biomet Manufacturing Corp. | Irradiated implantable bone material |
US7678385B2 (en) | 2004-04-28 | 2010-03-16 | Biomet Manufacturing Corp. | Irradiated implantable bone material |
US20100172954A1 (en) * | 2004-04-28 | 2010-07-08 | Biomet Manufacturing Corp. | Irradiated implantable bone material |
US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
US20050263930A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7122138B2 (en) | 2004-05-25 | 2006-10-17 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263922A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7097792B2 (en) | 2004-05-25 | 2006-08-29 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263919A1 (en) * | 2004-05-25 | 2005-12-01 | Lin Jiin-Huey C | Dual function prosthetic bone implant and method for preparing the same |
US20050263921A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7115222B2 (en) | 2004-05-25 | 2006-10-03 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050267604A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7118695B2 (en) | 2004-05-25 | 2006-10-10 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263928A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7083749B2 (en) | 2004-05-25 | 2006-08-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7122140B2 (en) | 2004-05-25 | 2006-10-17 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7122139B2 (en) | 2004-05-25 | 2006-10-17 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263929A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7128856B2 (en) | 2004-05-25 | 2006-10-31 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263920A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050267592A1 (en) * | 2004-05-25 | 2005-12-01 | Jiin-Huey Chern Lin | Dual function prosthetic bone implant and method for preparing the same |
US7157027B2 (en) | 2004-05-25 | 2007-01-02 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263931A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050267588A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US7182895B2 (en) | 2004-05-25 | 2007-02-27 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050267587A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20050263927A1 (en) * | 2004-05-25 | 2005-12-01 | Calcitec, Inc. | Dual function prosthetic bone implant and method for preparing the same |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
US9387082B2 (en) | 2004-10-05 | 2016-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogel arthroplasty device |
US8679190B2 (en) | 2004-10-05 | 2014-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | Hydrogel arthroplasty device |
US8292968B2 (en) | 2004-10-12 | 2012-10-23 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US10258566B2 (en) | 2004-10-14 | 2019-04-16 | Biomimetic Therapeutics, Llc | Compositions and methods for treating bone |
US11571497B2 (en) | 2004-10-14 | 2023-02-07 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
US20070259814A1 (en) * | 2004-10-14 | 2007-11-08 | Lynch Samuel E | Platelet Derived Growth Factor and Methods of Use Thereof |
US7799754B2 (en) | 2004-10-14 | 2010-09-21 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
US9545377B2 (en) | 2004-10-14 | 2017-01-17 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
US11364325B2 (en) | 2004-10-14 | 2022-06-21 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
US20060084602A1 (en) * | 2004-10-14 | 2006-04-20 | Lynch Samuel E | Platelet-derived growth factor compositions and methods of use thereof |
US8114841B2 (en) | 2004-10-14 | 2012-02-14 | Biomimetic Therapeutics, Inc. | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
US11318230B2 (en) | 2004-10-14 | 2022-05-03 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods of use thereof |
US20070129807A1 (en) * | 2004-10-14 | 2007-06-07 | Lynch Samuel E | Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix |
US7517358B2 (en) | 2004-11-22 | 2009-04-14 | Orthopedic Development Corporation | Implant device used in minimally invasive facet joint hemi-arthroplasty |
US7708761B2 (en) | 2004-11-22 | 2010-05-04 | Minsurg International, Inc. | Spinal plug for a minimally invasive facet joint fusion system |
US8021392B2 (en) | 2004-11-22 | 2011-09-20 | Minsurg International, Inc. | Methods and surgical kits for minimally-invasive facet joint fusion |
US20060111786A1 (en) * | 2004-11-22 | 2006-05-25 | Orthopedic Development Corporation | Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty |
US20060229723A1 (en) * | 2005-04-08 | 2006-10-12 | Sdgi Holdings, Inc. | Intervertebral fusion device and method |
US7621963B2 (en) | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
US20060233849A1 (en) * | 2005-04-13 | 2006-10-19 | Simon Bruce J | Composite bone graft material |
US20060233851A1 (en) * | 2005-04-13 | 2006-10-19 | Ebi, L.P. | Composite bone graft material |
US20060258578A1 (en) * | 2005-05-10 | 2006-11-16 | The University Of Zurich | Pharmaceutical composition |
US9662146B2 (en) | 2005-05-12 | 2017-05-30 | Joseph D. Stern | Revisable anterior cervical plating system |
US8070749B2 (en) | 2005-05-12 | 2011-12-06 | Stern Joseph D | Revisable anterior cervical plating system |
US8858556B2 (en) | 2005-05-12 | 2014-10-14 | Joseph D. Stern | Revisable anterior cervical plating system |
US9668782B2 (en) | 2005-05-12 | 2017-06-06 | Joseph D. Stern | Revisable anterior cervical plating system |
US20090264886A1 (en) * | 2005-05-12 | 2009-10-22 | Stern Joseph D | Distraction device for use with a revisable anterior cervical plating system |
US9095381B2 (en) | 2005-05-12 | 2015-08-04 | Joseph D. Stern | Revisable anterior cervical plating system |
US10383665B2 (en) | 2005-05-12 | 2019-08-20 | Globus Medical, Inc. | Revisable anterior cervical plating system |
US20060271052A1 (en) * | 2005-05-12 | 2006-11-30 | Stern Joseph D | Revisable anterior cervical plating system |
US8556895B2 (en) | 2005-05-12 | 2013-10-15 | Joseph D. Stern | Revisable anterior cervical plating system |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
US20070075016A1 (en) * | 2005-08-23 | 2007-04-05 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
US8048320B2 (en) | 2005-08-23 | 2011-11-01 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
US20070208321A1 (en) * | 2005-08-23 | 2007-09-06 | Biomet Manufacturing Corp. | Method And Apparatus For Collecting Biological Materials |
US8236258B2 (en) | 2005-08-23 | 2012-08-07 | Biomet Biologics, Llc | Method and apparatus for collecting biological materials |
US20100255977A1 (en) * | 2005-08-23 | 2010-10-07 | Biomet Manufacturing Corp. | Method and Apparatus for Collecting Biological Materials |
US8048297B2 (en) | 2005-08-23 | 2011-11-01 | Biomet Biologics, Llc | Method and apparatus for collecting biological materials |
US8512575B2 (en) | 2005-08-23 | 2013-08-20 | Biomet Biologics, Llc | Method and apparatus for collecting biological materials |
US7771590B2 (en) | 2005-08-23 | 2010-08-10 | Biomet Manufacturing Corp. | Method and apparatus for collecting biological materials |
US20070074980A1 (en) * | 2005-09-02 | 2007-04-05 | Bankoski Brian R | Implant rehydration packages and methods of use |
US9701940B2 (en) | 2005-09-19 | 2017-07-11 | Histogenics Corporation | Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof |
US7691105B2 (en) | 2005-09-26 | 2010-04-06 | Depuy Spine, Inc. | Tissue augmentation, stabilization and regeneration technique |
US20070083205A1 (en) * | 2005-09-26 | 2007-04-12 | Mohamed Attawia | Tissue augmentation, stabilization and regeneration Technique |
US8911759B2 (en) | 2005-11-01 | 2014-12-16 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US10328179B2 (en) | 2005-11-01 | 2019-06-25 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US8992965B2 (en) | 2005-11-01 | 2015-03-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US7901458B2 (en) | 2005-12-16 | 2011-03-08 | Warsaw Orthopedic, Inc. | Intervertebral spacer and insertion tool |
US20070162128A1 (en) * | 2005-12-16 | 2007-07-12 | Sdgi Holdings, Inc. | Intervertebral spacer and insertion tool |
US9034356B2 (en) | 2006-01-19 | 2015-05-19 | Warsaw Orthopedic, Inc. | Porous osteoimplant |
US20070270971A1 (en) * | 2006-03-14 | 2007-11-22 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc with improved wear resistance |
US20070233246A1 (en) * | 2006-03-31 | 2007-10-04 | Sdgi Holdings, Inc. | Spinal implants with improved mechanical response |
US9254156B2 (en) | 2006-04-26 | 2016-02-09 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US11331132B2 (en) | 2006-04-26 | 2022-05-17 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US10456184B2 (en) | 2006-04-26 | 2019-10-29 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US9265549B2 (en) | 2006-04-26 | 2016-02-23 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US7806900B2 (en) | 2006-04-26 | 2010-10-05 | Illuminoss Medical, Inc. | Apparatus and methods for delivery of reinforcing materials to bone |
US8246628B2 (en) | 2006-04-26 | 2012-08-21 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US7811290B2 (en) | 2006-04-26 | 2010-10-12 | Illuminoss Medical, Inc. | Apparatus and methods for reinforcing bone |
US8668701B2 (en) | 2006-04-26 | 2014-03-11 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US9724147B2 (en) | 2006-04-26 | 2017-08-08 | Illuminoss Medical, Inc. | Apparatus for delivery of reinforcing materials to bone |
US8348956B2 (en) | 2006-04-26 | 2013-01-08 | Illuminoss Medical, Inc. | Apparatus and methods for reinforcing bone |
US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US10456450B2 (en) | 2006-06-30 | 2019-10-29 | Biomimetic Therapeutics, Llc | Compositions and methods for treating rotator cuff injuries |
US11058801B2 (en) | 2006-06-30 | 2021-07-13 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
US9642891B2 (en) | 2006-06-30 | 2017-05-09 | Biomimetic Therapeutics, Llc | Compositions and methods for treating rotator cuff injuries |
US20080021557A1 (en) * | 2006-07-24 | 2008-01-24 | Warsaw Orthopedic, Inc. | Spinal motion-preserving implants |
US20080021462A1 (en) * | 2006-07-24 | 2008-01-24 | Warsaw Orthopedic Inc. | Spinal stabilization implants |
US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
US7879041B2 (en) | 2006-11-10 | 2011-02-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US10543025B2 (en) | 2006-11-10 | 2020-01-28 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US7811284B2 (en) | 2006-11-10 | 2010-10-12 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US8734460B2 (en) | 2006-11-10 | 2014-05-27 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US11793556B2 (en) | 2006-11-10 | 2023-10-24 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US20080125784A1 (en) * | 2006-11-10 | 2008-05-29 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US9433450B2 (en) | 2006-11-10 | 2016-09-06 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US8906031B2 (en) | 2006-11-10 | 2014-12-09 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US9717542B2 (en) | 2006-11-10 | 2017-08-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US11259847B2 (en) | 2006-11-10 | 2022-03-01 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US8366711B2 (en) | 2006-11-10 | 2013-02-05 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US8906030B2 (en) | 2006-11-10 | 2014-12-09 | Illuminoss Medical, Inc. | Systems and methods for internal bone fixation |
US7871440B2 (en) | 2006-12-11 | 2011-01-18 | Depuy Products, Inc. | Unitary surgical device and method |
US8742072B2 (en) | 2006-12-21 | 2014-06-03 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US8906110B2 (en) | 2007-01-24 | 2014-12-09 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US8430879B2 (en) | 2007-03-22 | 2013-04-30 | Sonoma Orthopedic Products, Inc. | Segmented intramedullary structure |
US8496658B2 (en) | 2007-03-22 | 2013-07-30 | Sonoma Orthopedic Products, Inc. | Segmented intramedullary structure |
US8128627B2 (en) | 2007-03-22 | 2012-03-06 | Sonoma Orthopedic Products, Inc. | Segmented intramedullary system and apparatus |
US9649579B2 (en) | 2007-04-12 | 2017-05-16 | Hanuman Llc | Buoy suspension fractionation system |
US8596470B2 (en) | 2007-04-12 | 2013-12-03 | Hanuman, Llc | Buoy fractionation system |
US9138664B2 (en) | 2007-04-12 | 2015-09-22 | Biomet Biologics, Llc | Buoy fractionation system |
US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
US7806276B2 (en) | 2007-04-12 | 2010-10-05 | Hanuman, Llc | Buoy suspension fractionation system |
US8119013B2 (en) | 2007-04-12 | 2012-02-21 | Hanuman, Llc | Method of separating a selected component from a multiple component material |
US10357511B2 (en) | 2007-06-15 | 2019-07-23 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
EP3207948A1 (en) | 2007-06-15 | 2017-08-23 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US10220115B2 (en) | 2007-06-15 | 2019-03-05 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
US9554920B2 (en) | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
US8357384B2 (en) | 2007-06-15 | 2013-01-22 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US8642061B2 (en) | 2007-06-15 | 2014-02-04 | Warsaw Orthopedic, Inc. | Method of treating bone tissue |
US9717822B2 (en) | 2007-06-15 | 2017-08-01 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US9358113B2 (en) | 2007-07-10 | 2016-06-07 | Warsaw Orthopedic, Inc. | Delivery system |
US9492278B2 (en) | 2007-07-10 | 2016-11-15 | Warsaw Orthopedic, Inc. | Delivery system |
US10028837B2 (en) | 2007-07-10 | 2018-07-24 | Warsaw Orthopedic, Inc. | Delivery system attachment |
US9333082B2 (en) | 2007-07-10 | 2016-05-10 | Warsaw Orthopedic, Inc. | Delivery system attachment |
US9138509B2 (en) | 2007-09-14 | 2015-09-22 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US20090074871A1 (en) * | 2007-09-14 | 2009-03-19 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
US20100211158A1 (en) * | 2007-10-16 | 2010-08-19 | Hkpb Scientific Limited | Surface coating processes and uses of same |
US8435566B2 (en) | 2007-10-19 | 2013-05-07 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
US8202539B2 (en) | 2007-10-19 | 2012-06-19 | Warsaw Orthopedic, Inc. | Demineralized bone matrix compositions and methods |
US9427289B2 (en) | 2007-10-31 | 2016-08-30 | Illuminoss Medical, Inc. | Light source |
EP3563883A1 (en) | 2007-11-09 | 2019-11-06 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
US9005254B2 (en) | 2007-12-26 | 2015-04-14 | Illuminoss Medical, Inc. | Methods for repairing craniomaxillofacial bones using customized bone plate |
US8672982B2 (en) | 2007-12-26 | 2014-03-18 | Illuminoss Medical, Inc. | Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates |
US8403968B2 (en) | 2007-12-26 | 2013-03-26 | Illuminoss Medical, Inc. | Apparatus and methods for repairing craniomaxillofacial bones using customized bone plates |
US8349796B2 (en) | 2008-02-07 | 2013-01-08 | Biomimetic Therapeutics Inc. | Methods for treatment of distraction osteogenesis using PDGF |
US7943573B2 (en) | 2008-02-07 | 2011-05-17 | Biomimetic Therapeutics, Inc. | Methods for treatment of distraction osteogenesis using PDGF |
US10400017B2 (en) | 2008-02-27 | 2019-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US11725031B2 (en) | 2008-02-27 | 2023-08-15 | Biomet Manufacturing, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US9701728B2 (en) | 2008-02-27 | 2017-07-11 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
US8337711B2 (en) | 2008-02-29 | 2012-12-25 | Biomet Biologics, Llc | System and process for separating a material |
US9719063B2 (en) | 2008-02-29 | 2017-08-01 | Biomet Biologics, Llc | System and process for separating a material |
US8801586B2 (en) * | 2008-02-29 | 2014-08-12 | Biomet Biologics, Llc | System and process for separating a material |
US20100082072A1 (en) * | 2008-03-28 | 2010-04-01 | Sybert Daryl R | Bone anchors for orthopedic applications |
WO2009120248A1 (en) | 2008-03-28 | 2009-10-01 | Osteotech, Inc. | Delivery system attachment |
EP3366318A1 (en) | 2008-03-28 | 2018-08-29 | Warsaw Orthopedic, Inc. | Delivery system attachment |
US10457803B2 (en) | 2008-07-07 | 2019-10-29 | Hyalex Orthopaedics, Inc. | Orthopedic implants having gradient polymer alloys |
US8883915B2 (en) | 2008-07-07 | 2014-11-11 | Biomimedica, Inc. | Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same |
US10752768B2 (en) | 2008-07-07 | 2020-08-25 | Hyalex Orthopaedics, Inc. | Orthopedic implants having gradient polymer alloys |
RU2491960C9 (en) * | 2008-07-08 | 2013-11-10 | Истоселль, С.Л. | Three-dimensional matrixes from structured porous monetite for tissue engineering and bone regeneration and method of their obtaining |
RU2491960C2 (en) * | 2008-07-08 | 2013-09-10 | Истоселль, С.Л. | Three-dimensional matrixes from structured porous monetite for tissue engineering and bone regeneration and method of their obtaining |
US8497023B2 (en) | 2008-08-05 | 2013-07-30 | Biomimedica, Inc. | Polyurethane-grafted hydrogels |
US8853294B2 (en) | 2008-08-05 | 2014-10-07 | Biomimedica, Inc. | Polyurethane-grafted hydrogels |
US8870954B2 (en) | 2008-09-09 | 2014-10-28 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
US11135341B2 (en) | 2008-09-09 | 2021-10-05 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor composition and methods for the treatment of tendon and ligament injuries |
US20100151114A1 (en) * | 2008-12-17 | 2010-06-17 | Zimmer, Inc. | In-line treatment of yarn prior to creating a fabric |
US9101475B2 (en) | 2009-02-12 | 2015-08-11 | Warsaw Orthopedic, Inc. | Segmented delivery system |
WO2010093955A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech,Inc. | Segmented delivery system |
WO2010093950A1 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery system cartridge |
US9011537B2 (en) | 2009-02-12 | 2015-04-21 | Warsaw Orthopedic, Inc. | Delivery system cartridge |
US10098681B2 (en) | 2009-02-12 | 2018-10-16 | Warsaw Orthopedic, Inc. | Segmented delivery system |
WO2010093959A2 (en) | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery systems, tools, and methods of use |
US9220598B2 (en) | 2009-02-12 | 2015-12-29 | Warsaw Orthopedic, Inc. | Delivery systems, tools, and methods of use |
US8783470B2 (en) | 2009-03-06 | 2014-07-22 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
US9241798B2 (en) * | 2009-03-20 | 2016-01-26 | David A. Petersen | Surgical methods and tools |
US20100268228A1 (en) * | 2009-03-20 | 2010-10-21 | Minsurg International, Inc. | Surgical methods and tools |
US8992862B2 (en) | 2009-04-03 | 2015-03-31 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
US8210729B2 (en) | 2009-04-06 | 2012-07-03 | Illuminoss Medical, Inc. | Attachment system for light-conducting fibers |
US8936382B2 (en) | 2009-04-06 | 2015-01-20 | Illuminoss Medical, Inc. | Attachment system for light-conducting fibers |
US8328402B2 (en) | 2009-04-06 | 2012-12-11 | Illuminoss Medical, Inc. | Attachment system for light-conducting fibers |
US8512338B2 (en) | 2009-04-07 | 2013-08-20 | Illuminoss Medical, Inc. | Photodynamic bone stabilization systems and methods for reinforcing bone |
US8574233B2 (en) | 2009-04-07 | 2013-11-05 | Illuminoss Medical, Inc. | Photodynamic bone stabilization systems and methods for reinforcing bone |
US20100297082A1 (en) * | 2009-05-19 | 2010-11-25 | Osteotech, Inc. | Weight-bearing polyurethane composites and methods thereof |
US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
WO2011017284A2 (en) | 2009-08-03 | 2011-02-10 | Osteotech, Inc. | Bone matrix compositions and methods |
EP3342432A1 (en) | 2009-08-03 | 2018-07-04 | Warsaw Orthopedic, Inc. | Bone matrix compositions and methods |
US8926552B2 (en) | 2009-08-12 | 2015-01-06 | Medtronic, Inc. | Particle delivery |
US20110040279A1 (en) * | 2009-08-12 | 2011-02-17 | Medtronic, Inc. | Particle Delivery |
US10286118B2 (en) | 2009-08-12 | 2019-05-14 | Medtronic, Inc. | Particle delivery |
US9125706B2 (en) | 2009-08-19 | 2015-09-08 | Illuminoss Medical, Inc. | Devices and methods for bone alignment, stabilization and distraction |
US8915966B2 (en) | 2009-08-19 | 2014-12-23 | Illuminoss Medical, Inc. | Devices and methods for bone alignment, stabilization and distraction |
US8870965B2 (en) | 2009-08-19 | 2014-10-28 | Illuminoss Medical, Inc. | Devices and methods for bone alignment, stabilization and distraction |
US20110150963A1 (en) * | 2009-12-21 | 2011-06-23 | Clineff Theodore D | Bioactive antibacterial bone graft materials |
US8778378B2 (en) | 2009-12-21 | 2014-07-15 | Orthovita, Inc. | Bioactive antibacterial bone graft materials |
US9486500B2 (en) | 2010-01-28 | 2016-11-08 | Warsaw Orthopedic, Inc. | Osteoimplant and methods for making |
US9125902B2 (en) | 2010-01-28 | 2015-09-08 | Warsaw Orthopedic, Inc. | Methods for treating an intervertebral disc using local analgesics |
US9050274B2 (en) | 2010-01-28 | 2015-06-09 | Warsaw Orthopedic, Inc. | Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents |
US20110182849A1 (en) * | 2010-01-28 | 2011-07-28 | Warsaw Orthopedic, Inc. | Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents |
US20110189253A1 (en) * | 2010-01-29 | 2011-08-04 | Warsaw Orthopedic, Inc. | Biomaterial composition and method |
US11235030B2 (en) | 2010-02-22 | 2022-02-01 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
US8492335B2 (en) | 2010-02-22 | 2013-07-23 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
US9533090B2 (en) | 2010-04-12 | 2017-01-03 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US11305035B2 (en) | 2010-05-14 | 2022-04-19 | Musculoskeletal Transplant Foundatiaon | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8684965B2 (en) | 2010-06-21 | 2014-04-01 | Illuminoss Medical, Inc. | Photodynamic bone stabilization and drug delivery systems |
US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
US9855080B2 (en) | 2010-12-22 | 2018-01-02 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US10772664B2 (en) | 2010-12-22 | 2020-09-15 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US10111689B2 (en) | 2010-12-22 | 2018-10-30 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US9179959B2 (en) | 2010-12-22 | 2015-11-10 | Illuminoss Medical, Inc. | Systems and methods for treating conditions and diseases of the spine |
US9220596B2 (en) | 2010-12-23 | 2015-12-29 | Biostructures, Llc | Bone graft materials and methods |
US8551525B2 (en) | 2010-12-23 | 2013-10-08 | Biostructures, Llc | Bone graft materials and methods |
US20200281725A1 (en) * | 2011-02-28 | 2020-09-10 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US20190000628A1 (en) * | 2011-02-28 | 2019-01-03 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US10500053B2 (en) * | 2011-02-28 | 2019-12-10 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US12023251B2 (en) * | 2011-02-28 | 2024-07-02 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US11793644B2 (en) | 2011-02-28 | 2023-10-24 | DePuy Synthes Products, Inc. | Modular tissue scaffolds |
US9239276B2 (en) | 2011-04-19 | 2016-01-19 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US9254195B2 (en) | 2011-07-19 | 2016-02-09 | Illuminoss Medical, Inc. | Systems and methods for joint stabilization |
US11559343B2 (en) | 2011-07-19 | 2023-01-24 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US9144442B2 (en) | 2011-07-19 | 2015-09-29 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US9775661B2 (en) | 2011-07-19 | 2017-10-03 | Illuminoss Medical, Inc. | Devices and methods for bone restructure and stabilization |
US8936644B2 (en) | 2011-07-19 | 2015-01-20 | Illuminoss Medical, Inc. | Systems and methods for joint stabilization |
US11141207B2 (en) | 2011-07-19 | 2021-10-12 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US10292823B2 (en) | 2011-07-19 | 2019-05-21 | Illuminoss Medical, Inc. | Photodynamic articular joint implants and methods of use |
US9855145B2 (en) | 2011-07-19 | 2018-01-02 | IlluminsOss Medical, Inc. | Systems and methods for joint stabilization |
US11015016B2 (en) | 2011-10-03 | 2021-05-25 | Hyalex Orthopaedics, Inc. | Polymeric adhesive for anchoring compliant materials to another surface |
US11760830B2 (en) | 2011-10-03 | 2023-09-19 | Hyalex Orthopaedics, Inc. | Polymeric adhesive for anchoring compliant materials to another surface |
US9114024B2 (en) | 2011-11-21 | 2015-08-25 | Biomimedica, Inc. | Systems, devices, and methods for anchoring orthopaedic implants to bone |
US20140309747A1 (en) * | 2011-12-12 | 2014-10-16 | Solana Surgical, Llc | Fusion Implant |
US10463407B2 (en) | 2011-12-12 | 2019-11-05 | Wright Medical Technology, Inc. | Fusion implant |
US9554914B2 (en) * | 2011-12-12 | 2017-01-31 | Wright Medical Technology, Inc. | Fusion implant |
US8992628B2 (en) | 2012-01-20 | 2015-03-31 | Warsaw Orthopedic, Inc. | Bone delivery system |
US9198758B2 (en) | 2012-01-26 | 2015-12-01 | Warsaw Orthopedic, Inc. | Delivery systems |
US10548923B2 (en) | 2012-01-30 | 2020-02-04 | Warsaw Orthopedic, Inc. | Modification of reactivity of bone constructs |
US9775862B2 (en) | 2012-01-30 | 2017-10-03 | Warsaw Orthopedic, Inc. | Modification of reactivity of bone constructs |
US8926622B2 (en) | 2012-04-03 | 2015-01-06 | Warsaw Orthopedic, Inc. | Bone delivery systems including holding and filling devices and methods |
US9241797B2 (en) | 2012-04-03 | 2016-01-26 | Warsaw Orthopedic, Inc. | Bone delivery systems including holding and filling devices and methods |
WO2013169366A1 (en) | 2012-05-11 | 2013-11-14 | Rti Biologics, Inc. | Xenograft soft tissue implants and methods of making and using |
US8939977B2 (en) | 2012-07-10 | 2015-01-27 | Illuminoss Medical, Inc. | Systems and methods for separating bone fixation devices from introducer |
US9655994B2 (en) | 2012-07-25 | 2017-05-23 | William F. McKay | Delivery systems |
US10532129B2 (en) | 2012-07-25 | 2020-01-14 | Warsaw Orthopedic, Inc. | Delivery systems |
US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
US20140121772A1 (en) * | 2012-10-25 | 2014-05-01 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US10172651B2 (en) * | 2012-10-25 | 2019-01-08 | Warsaw Orthopedic, Inc. | Cortical bone implant |
US9687281B2 (en) | 2012-12-20 | 2017-06-27 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
US10575882B2 (en) | 2012-12-20 | 2020-03-03 | Illuminoss Medical, Inc. | Distal tip for bone fixation devices |
US10820999B2 (en) | 2013-01-08 | 2020-11-03 | Warsaw Orthopedic, Inc. | Osteograft implant |
US9949832B2 (en) | 2013-01-08 | 2018-04-24 | Warsaw Orthopedic, Inc. | Osteograft implant |
US9265609B2 (en) | 2013-01-08 | 2016-02-23 | Warsaw Orthopedic, Inc. | Osteograft implant |
US9034052B2 (en) | 2013-01-14 | 2015-05-19 | Warsaw Orthopedic, Inc. | Delivery systems containing bioactive materials |
US9414939B2 (en) | 2013-01-14 | 2016-08-16 | Warsaw Orthopedic, Inc. | Delivery systems containing bioactive materials |
US9283013B2 (en) | 2013-03-14 | 2016-03-15 | Warsaw Orthopedic, Inc. | Filling systems for bone delivery devices |
US9901381B2 (en) | 2013-03-14 | 2018-02-27 | Warsaw Orthopedic, Inc. | Filling systems for bone delivery devices |
US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US11083511B2 (en) | 2013-03-15 | 2021-08-10 | Orthocision Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US10576130B2 (en) | 2013-03-15 | 2020-03-03 | Biomet Manufacturing, Llc | Treatment of collagen defects using protein solutions |
US10321945B2 (en) | 2013-03-15 | 2019-06-18 | Orthocision Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US10441634B2 (en) | 2013-03-15 | 2019-10-15 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
US11957733B2 (en) | 2013-03-15 | 2024-04-16 | Biomet Manufacturing, Llc | Treatment of collagen defects using protein solutions |
US9556243B2 (en) | 2013-03-15 | 2017-01-31 | Biomet Biologies, LLC | Methods for making cytokine compositions from tissues using non-centrifugal methods |
US10993757B2 (en) | 2013-03-15 | 2021-05-04 | Orthocision Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US10426539B2 (en) | 2013-03-15 | 2019-10-01 | Orthocision Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US9119732B2 (en) | 2013-03-15 | 2015-09-01 | Orthocision, Inc. | Method and implant system for sacroiliac joint fixation and fusion |
US11576999B2 (en) | 2013-10-09 | 2023-02-14 | Lifenet Health | Compressed bone composition and methods of use thereof |
US10780196B2 (en) | 2013-10-09 | 2020-09-22 | Lifenet Health | Compressed bone composition and methods of use thereof |
AU2014331769B2 (en) * | 2013-10-09 | 2019-01-24 | Lifenet Health | Compressed bone composition and methods of use thereof |
KR20160067902A (en) | 2013-10-09 | 2016-06-14 | 라이프넷 헬스 | Compressed bone composition and methods of use thereof |
WO2015054547A1 (en) * | 2013-10-09 | 2015-04-16 | Lifenet Health | Compressed bone composition and methods of use thereof |
RU2557893C1 (en) * | 2014-04-10 | 2015-07-27 | Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "ЦИТО им. Н.Н. Приорова" Минздрава России) | Method for two-staged surgical treatment of spinal deformity with using autopreserved resected rib autograft and dry vertical halotraction |
US9364583B2 (en) | 2014-04-25 | 2016-06-14 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized bone implant |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
US11555172B2 (en) | 2014-12-02 | 2023-01-17 | Ocugen, Inc. | Cell and tissue culture container |
US10006705B2 (en) | 2015-02-09 | 2018-06-26 | Warsaw Orthopedic, Inc. | Methods for treating tissue materials |
US11596517B2 (en) | 2015-05-21 | 2023-03-07 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US10531957B2 (en) | 2015-05-21 | 2020-01-14 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
US11077228B2 (en) | 2015-08-10 | 2021-08-03 | Hyalex Orthopaedics, Inc. | Interpenetrating polymer networks |
US11938245B2 (en) | 2015-08-19 | 2024-03-26 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US11806443B2 (en) | 2015-08-19 | 2023-11-07 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
WO2017147117A1 (en) | 2016-02-24 | 2017-08-31 | Warsaw Orthopedic, Inc. | Spinal implant system and method |
US11311383B2 (en) | 2016-02-24 | 2022-04-26 | Warsaw Orthopedic, Inc. | Spinal implant system and method |
US10383731B2 (en) | 2016-02-24 | 2019-08-20 | Warsaw Orthopedic, Inc. | Spinal implant system and method |
WO2017201259A1 (en) | 2016-05-18 | 2017-11-23 | Rti Surgical, Inc. | Osteoinductive nanofiber scaffold for bone regeneration |
US10441426B2 (en) | 2017-04-18 | 2019-10-15 | Warsaw Orthopedic, Inc. | 3D printing of mesh implants for bone delivery |
US10064726B1 (en) | 2017-04-18 | 2018-09-04 | Warsaw Orthopedic, Inc. | 3D printing of mesh implants for bone delivery |
US11660196B2 (en) | 2017-04-21 | 2023-05-30 | Warsaw Orthopedic, Inc. | 3-D printing of bone grafts |
US10970789B2 (en) | 2018-01-23 | 2021-04-06 | Full Circle Innovation Llc | Systems and methods for facilitating insurance coverage |
US11147567B2 (en) | 2018-02-28 | 2021-10-19 | Joint Restoration Foundation, Inc. | Methods and devices for restoration of a bone surface |
US11071572B2 (en) | 2018-06-27 | 2021-07-27 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US11419649B2 (en) | 2018-06-27 | 2022-08-23 | Illuminoss Medical, Inc. | Systems and methods for bone stabilization and fixation |
US11110200B2 (en) | 2018-07-17 | 2021-09-07 | Hyalex Orthopaedics, Inc. | Ionic polymer compositions |
US11364322B2 (en) | 2018-07-17 | 2022-06-21 | Hyalex Orthopaedics, Inc. | Ionic polymer compositions |
US10869950B2 (en) | 2018-07-17 | 2020-12-22 | Hyalex Orthopaedics, Inc. | Ionic polymer compositions |
US10792392B2 (en) | 2018-07-17 | 2020-10-06 | Hyalex Orthopedics, Inc. | Ionic polymer compositions |
US20220330995A1 (en) * | 2021-04-15 | 2022-10-20 | Jeremy M. Gililland | Knee sizing tool and systems and methods for use in total knee replacement procedure |
Also Published As
Publication number | Publication date |
---|---|
CA2363153C (en) | 2011-04-26 |
JP4658331B2 (en) | 2011-03-23 |
AU758828B2 (en) | 2003-04-03 |
JP2002537073A (en) | 2002-11-05 |
KR100754814B1 (en) | 2007-09-03 |
AU3703300A (en) | 2000-09-14 |
EP1152777B1 (en) | 2006-05-03 |
DE60027698T2 (en) | 2007-04-26 |
EP1152777A1 (en) | 2001-11-14 |
ES2261191T3 (en) | 2006-11-16 |
CA2363153A1 (en) | 2000-08-31 |
US6294187B1 (en) | 2001-09-25 |
DE60027698D1 (en) | 2006-06-08 |
US20010043940A1 (en) | 2001-11-22 |
TR200102480T2 (en) | 2001-12-21 |
KR20010104351A (en) | 2001-11-24 |
WO2000050102A1 (en) | 2000-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6440444B2 (en) | Load bearing osteoimplant and method of repairing bone using the same | |
US8133421B2 (en) | Methods of making shaped load-bearing osteoimplant | |
US6696073B2 (en) | Shaped load-bearing osteoimplant and methods of making same | |
US7001551B2 (en) | Method of forming a composite bone material implant | |
US6616698B2 (en) | Bone graft and guided bone regeneration method | |
US20070233272A1 (en) | Shaped load-bearing osteoimplant and methods of making same | |
US5507813A (en) | Shaped materials derived from elongate bone particles | |
CA2415061C (en) | Osteogenic implants derived from bone | |
AU2001275999B2 (en) | Osteoimplant and method of making same | |
US6843807B1 (en) | Osteoimplant | |
AU2001270153A1 (en) | Osteogenic implants derived from bone | |
AU2001275999A1 (en) | Osteoimplant and method of making same | |
US20120245703A1 (en) | Composite bone material implant and method | |
US20090098092A1 (en) | Composite Bone Material and Method of Making and Using Same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
AS | Assignment |
Owner name: OSTEOTECH, INC., NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BOYCE, TODD M.;SHIMP, LAWRENCE A.;MANRIQUE, ALBERT;REEL/FRAME:025026/0599 Effective date: 19990225 |
|
FEPP | Fee payment procedure |
Free format text: PAT HOLDER NO LONGER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: STOL); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
AS | Assignment |
Owner name: WARSAW ORTHOPEDIC, INC., INDIANA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:OSTEOTECH, INC.;REEL/FRAME:026196/0585 Effective date: 20110415 |
|
FPAY | Fee payment |
Year of fee payment: 12 |