US5883231A - Artificial menses fluid - Google Patents

Artificial menses fluid Download PDF

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Publication number
US5883231A
US5883231A US08/916,993 US91699397A US5883231A US 5883231 A US5883231 A US 5883231A US 91699397 A US91699397 A US 91699397A US 5883231 A US5883231 A US 5883231A
Authority
US
United States
Prior art keywords
fluid
egg white
plasma
amount
weight percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08/916,993
Other languages
English (en)
Inventor
Amy Michele Achter
Crystal Sutphin Leach
Jack Nelson Lindon
Heather Anne Sorebo
Mary Garvie Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kimberly Clark Worldwide Inc
Original Assignee
Kimberly Clark Worldwide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Worldwide Inc filed Critical Kimberly Clark Worldwide Inc
Priority to US08/916,993 priority Critical patent/US5883231A/en
Assigned to KIMBERLY-CLARK WORLDWIDE, INC. reassignment KIMBERLY-CLARK WORLDWIDE, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEBER, MARY G., SOREBO, HEATHER A., ACHTER, AMY M., LEACH, CRYSTAL S., LINDON, JACK N.
Priority to JP54933698A priority patent/JP4335320B2/ja
Priority to PCT/US1998/009473 priority patent/WO1998051353A2/en
Priority to AU74768/98A priority patent/AU7476898A/en
Priority to DE69812606T priority patent/DE69812606T8/de
Priority to CA002287229A priority patent/CA2287229C/en
Priority to EP98922163A priority patent/EP0981379B1/de
Publication of US5883231A publication Critical patent/US5883231A/en
Application granted granted Critical
Assigned to KIMBERLY-CLARK WORLDWIDE, INC. reassignment KIMBERLY-CLARK WORLDWIDE, INC. NAME CHANGE Assignors: KIMBERLY-CLARK WORLDWIDE, INC.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893—Preparing calibration standards

Definitions

  • BM artificial feces
  • Z-Date available from PPG Industries, Inc. of Pittsburgh, Penn.
  • PPG Industries, Inc. of Pittsburgh, Penn.
  • Yet another artificial menses fluid is mentioned in U.S. Pat. No. 4,321,924, incorporated herein by reference in its entirety, at column 7, lines 51-60.
  • a bodily fluid simulant made from red blood cells in an amount between about 10 and about 60 weight percent, egg white in an amount between 20 and 50 weight percent, and plasma.
  • an artificial menses fluid may be prepared as follows:
  • the egg white was separated into thick and thin portions by straining the white through a 1000 micron nylon mesh for about 3 minutes, and the thinner portion discarded. Note that alternative mesh sizes may be used and the time or method may be varied provided the viscosity is at least that required.
  • the thick portion of egg white which was retained on the mesh was collected and drawn into a 60 cc syringe which was then placed on a programmable syringe pump and homogenized by expelling and refilling the contents five times.
  • the amount of homogenization was controlled by the syringe pump rate of about 100 ml/min, and the tubing inside diameter of about 0.12 inches. After homogenizing the thick egg white had a viscosity of about 20 centipoise at 150 sec -1 and was then placed in the centrifuge and spun to remove -debris and air bubbles at about 3000 rpm for about 10 minutes, though any effective method to remove debris and bubbles may be used.
  • the thick, homogenized egg white which contains ovamucin, was added to a 300 cc FENWAL® TRANSFER PACK® container using a syringe. Then 60 cc of the swine plasma was added to the Transfer Pack® container. The Transfer Pack was clamped, all air bubbles removed, and placed in a Stomacher lab blender where it was blended at normal (or medium) speed for about 2 minutes. The Transfer Pack® container was then removed from the blender, 60 cc of swine red blood cells were added, and the contents mixed by hand kneading for about 2 minutes or until the contents appeared homogenous. A hematocrit of the final mixture showed a red blood cell content of about 30 weight percent and generally should be at least within a range of 28-32 weight percent for artificial menses made according to this example. The amount of egg white was about 40 weight percent.
  • FENWAL® TRANSFER PACK® container 300 ml, with coupler, code 4R2014: Baxter Healthcare Corporation, Fenwal Division, Deerfield, Ill. 60015.
  • CMN-1000-B Small Parts, Inc., PO Box4650,Miami Lakes, Fla. 33014-0650, 1-800-220-4242.
  • Hemata Stat-II device to measure hemocrits serial no.1194Z03127: Separation Technology, Inc., 1096 Rainer Drive, Altamont Springs, Fla. 32714.
  • an artificial menses fluid it is important to note that though only one example of an artificial menses fluid is given herein, the inventors have found that a range of ingredients and preparation conditions may be used to produce menses with properties varying from the example and useable for testing.
  • the inventors have found that the amount of red blood cells may be between about 10 and 60 weight percent or more particularly between about 25 and 40 weight percent.
  • the egg white may be between about 20 and 50 weight percent or more particularly between about 20 and 40 weight percent.
  • the balance may be plasma and, for example, an ingredient to simulate particulates.
  • the resulting fluid is useable for testing as an artificial menses fluid.
  • the preparation conditions may be varied by for example, centrifuging the ingredients at different speeds for different amounts of time from that shown in the example or straining the egg whites under different conditions,
  • ingredients may be varied, for example, by using bovine blood or human blood or by using eggs from other than chickens. Any of these changes are intended to be within the scope of the invention and are a means of providing particular menses simulants which have specifically desired properties for various types of testing and product development.
  • the artificial menses of this invention mimics the rheological and biochemical properties of genuine menses fluid.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Materials For Medical Uses (AREA)
US08/916,993 1997-05-14 1997-08-21 Artificial menses fluid Expired - Lifetime US5883231A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US08/916,993 US5883231A (en) 1997-05-14 1997-08-21 Artificial menses fluid
DE69812606T DE69812606T8 (de) 1997-05-14 1998-05-09 Künstliches Körperfluid
PCT/US1998/009473 WO1998051353A2 (en) 1997-05-14 1998-05-09 Artificial bodily fluid
AU74768/98A AU7476898A (en) 1997-05-14 1998-05-09 Artificial bodily fluid
JP54933698A JP4335320B2 (ja) 1997-05-14 1998-05-09 人工人体流体
CA002287229A CA2287229C (en) 1997-05-14 1998-05-09 Artificial bodily fluid
EP98922163A EP0981379B1 (de) 1997-05-14 1998-05-09 Künstliche körperflüssigkeit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4670297P 1997-05-14 1997-05-14
US08/916,993 US5883231A (en) 1997-05-14 1997-08-21 Artificial menses fluid

Publications (1)

Publication Number Publication Date
US5883231A true US5883231A (en) 1999-03-16

Family

ID=26724212

Family Applications (1)

Application Number Title Priority Date Filing Date
US08/916,993 Expired - Lifetime US5883231A (en) 1997-05-14 1997-08-21 Artificial menses fluid

Country Status (7)

Country Link
US (1) US5883231A (de)
EP (1) EP0981379B1 (de)
JP (1) JP4335320B2 (de)
AU (1) AU7476898A (de)
CA (1) CA2287229C (de)
DE (1) DE69812606T8 (de)
WO (1) WO1998051353A2 (de)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376011B1 (en) 1999-04-16 2002-04-23 Kimberly-Clark Worldwide, Inc. Process for preparing superabsorbent-containing composites
US6387495B1 (en) 1999-04-16 2002-05-14 Kimberly-Clark Worldwide, Inc. Superabsorbent-containing composites
US6409883B1 (en) 1999-04-16 2002-06-25 Kimberly-Clark Worldwide, Inc. Methods of making fiber bundles and fibrous structures
US6503233B1 (en) 1998-10-02 2003-01-07 Kimberly-Clark Worldwide, Inc. Absorbent article having good body fit under dynamic conditions
US6562192B1 (en) 1998-10-02 2003-05-13 Kimberly-Clark Worldwide, Inc. Absorbent articles with absorbent free-flowing particles and methods for producing the same
US6572735B1 (en) 1999-08-23 2003-06-03 Kimberly-Clark Worldwide, Inc. Wet-formed composite defining latent voids and macro-cavities
US20030125688A1 (en) * 2001-11-30 2003-07-03 Keane James M. Adhesive system for mechanically post-treated absorbent structures
US20030124336A1 (en) * 2001-11-30 2003-07-03 Keane James M. Adhesive system for absorbent structures
US20030135182A1 (en) * 2000-05-17 2003-07-17 Woon Paul S. Absorbent articles having improved performance
US6610903B1 (en) 1998-12-18 2003-08-26 Kimberly-Clark Worldwide, Inc. Materials for fluid management in personal care products
US6627789B1 (en) 1999-10-14 2003-09-30 Kimberly-Clark Worldwide, Inc. Personal care product with fluid partitioning
US6667424B1 (en) 1998-10-02 2003-12-23 Kimberly-Clark Worldwide, Inc. Absorbent articles with nits and free-flowing particles
US6679104B2 (en) 2001-12-20 2004-01-20 Kimberly-Clark Worldwide, Inc. Matched material combinations for absorbent articles and the like
US6723892B1 (en) 1999-10-14 2004-04-20 Kimberly-Clark Worldwide, Inc. Personal care products having reduced leakage
US20040102752A1 (en) * 1998-10-02 2004-05-27 Fung-Jou Chen Absorbent article with center fill performance
US6759567B2 (en) 2001-06-27 2004-07-06 Kimberly-Clark Worldwide, Inc. Pulp and synthetic fiber absorbent composites for personal care products
US20040186448A1 (en) * 2003-03-19 2004-09-23 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US20040253894A1 (en) * 2003-06-13 2004-12-16 Fell David A. Three dimensionally patterned stabilized absorbent material and method for producing same
US20040253892A1 (en) * 2003-06-13 2004-12-16 Kimberly-Clark Worldwide, Inc. Absorbent structure having three-dimensional topography on upper and lower surfaces
US6838590B2 (en) 2001-06-27 2005-01-04 Kimberly-Clark Worldwide, Inc. Pulp fiber absorbent composites for personal care products
US20050059942A1 (en) * 2003-09-17 2005-03-17 Kimberly-Clark Worldwide, Inc. Asymmetric multilayer absorbent article
US6979386B1 (en) 1999-08-23 2005-12-27 Kimberly-Clark Worldwide, Inc. Tissue products having increased absorbency
US20060004335A1 (en) * 2004-06-30 2006-01-05 Wang James H Unitary absorbent core
US20070249057A1 (en) * 2006-04-19 2007-10-25 Hood William H Menstrual fluid simulant
US20080147024A1 (en) * 2006-12-15 2008-06-19 Kimberly-Clark Worldwide, Inc. Treatment of personal care products to reduce leakage
US7943813B2 (en) 2002-12-30 2011-05-17 Kimberly-Clark Worldwide, Inc. Absorbent products with enhanced rewet, intake, and stain masking performance
WO2011128790A2 (en) 2010-04-16 2011-10-20 Kimberly-Clark Worldwide, Inc. Absorbent composite with a resilient coform layer
US20150140537A1 (en) * 2013-11-19 2015-05-21 Spectra Group Limited, Inc. Blood simulant for simulatoin-based medical trauma training
US9161869B2 (en) 2012-03-30 2015-10-20 Kimberly-Clark Worldwide, Inc. Absorbent articles with decolorizing agents
US9161868B2 (en) 2009-09-04 2015-10-20 Kimberly-Clark Worldwide, Inc. Removal of colored substances from aqueous liquids
US9237975B2 (en) 2013-09-27 2016-01-19 Kimberly-Clark Worldwide, Inc. Absorbent article with side barriers and decolorizing agents

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Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667424B1 (en) 1998-10-02 2003-12-23 Kimberly-Clark Worldwide, Inc. Absorbent articles with nits and free-flowing particles
US6503233B1 (en) 1998-10-02 2003-01-07 Kimberly-Clark Worldwide, Inc. Absorbent article having good body fit under dynamic conditions
US20040054331A1 (en) * 1998-10-02 2004-03-18 Hamilton Wendy L. Absorbent articles with nits and free-flowing particles
US6695827B2 (en) 1998-10-02 2004-02-24 Kimberly-Clark Worldwide, Inc. Absorbent article having good body fit under dynamic conditions
US6562192B1 (en) 1998-10-02 2003-05-13 Kimberly-Clark Worldwide, Inc. Absorbent articles with absorbent free-flowing particles and methods for producing the same
US20040102752A1 (en) * 1998-10-02 2004-05-27 Fung-Jou Chen Absorbent article with center fill performance
US6610903B1 (en) 1998-12-18 2003-08-26 Kimberly-Clark Worldwide, Inc. Materials for fluid management in personal care products
US6409883B1 (en) 1999-04-16 2002-06-25 Kimberly-Clark Worldwide, Inc. Methods of making fiber bundles and fibrous structures
US6387495B1 (en) 1999-04-16 2002-05-14 Kimberly-Clark Worldwide, Inc. Superabsorbent-containing composites
US6376011B1 (en) 1999-04-16 2002-04-23 Kimberly-Clark Worldwide, Inc. Process for preparing superabsorbent-containing composites
US6979386B1 (en) 1999-08-23 2005-12-27 Kimberly-Clark Worldwide, Inc. Tissue products having increased absorbency
US20030149415A1 (en) * 1999-08-23 2003-08-07 Wallajapet Palani Raj Ramaswami Wet-formed composite defining latent voids and macro-cavities
US6572735B1 (en) 1999-08-23 2003-06-03 Kimberly-Clark Worldwide, Inc. Wet-formed composite defining latent voids and macro-cavities
US6627789B1 (en) 1999-10-14 2003-09-30 Kimberly-Clark Worldwide, Inc. Personal care product with fluid partitioning
US6723892B1 (en) 1999-10-14 2004-04-20 Kimberly-Clark Worldwide, Inc. Personal care products having reduced leakage
US20030135182A1 (en) * 2000-05-17 2003-07-17 Woon Paul S. Absorbent articles having improved performance
US6838590B2 (en) 2001-06-27 2005-01-04 Kimberly-Clark Worldwide, Inc. Pulp fiber absorbent composites for personal care products
US6759567B2 (en) 2001-06-27 2004-07-06 Kimberly-Clark Worldwide, Inc. Pulp and synthetic fiber absorbent composites for personal care products
US20030125688A1 (en) * 2001-11-30 2003-07-03 Keane James M. Adhesive system for mechanically post-treated absorbent structures
US20030124336A1 (en) * 2001-11-30 2003-07-03 Keane James M. Adhesive system for absorbent structures
US6679104B2 (en) 2001-12-20 2004-01-20 Kimberly-Clark Worldwide, Inc. Matched material combinations for absorbent articles and the like
US7943813B2 (en) 2002-12-30 2011-05-17 Kimberly-Clark Worldwide, Inc. Absorbent products with enhanced rewet, intake, and stain masking performance
US20040186448A1 (en) * 2003-03-19 2004-09-23 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US7632258B2 (en) 2003-03-19 2009-12-15 Kimberly-Clark Worldwide, Inc. Multilayer absorbent article
US8617449B2 (en) 2003-06-13 2013-12-31 Kimberly-Clark Worldwide, Inc. Method of making an absorbent structure having three-dimensional topography
US20040253892A1 (en) * 2003-06-13 2004-12-16 Kimberly-Clark Worldwide, Inc. Absorbent structure having three-dimensional topography on upper and lower surfaces
US8932504B2 (en) 2003-06-13 2015-01-13 Kimberly-Clark Worldwide, Inc. Method of making absorbent structure having three-dimensional topography
US20040253894A1 (en) * 2003-06-13 2004-12-16 Fell David A. Three dimensionally patterned stabilized absorbent material and method for producing same
US8211815B2 (en) 2003-06-13 2012-07-03 Kimberly-Clark Worldwide, Inc. Absorbent structure having three-dimensional topography on upper and lower surfaces
US20050059942A1 (en) * 2003-09-17 2005-03-17 Kimberly-Clark Worldwide, Inc. Asymmetric multilayer absorbent article
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EP0981379A2 (de) 2000-03-01
JP4335320B2 (ja) 2009-09-30
CA2287229A1 (en) 1998-11-19
EP0981379B1 (de) 2003-03-26
AU7476898A (en) 1998-12-08
WO1998051353A3 (en) 1999-02-18
DE69812606D1 (de) 2003-04-30
CA2287229C (en) 2006-10-10
JP2001526568A (ja) 2001-12-18
DE69812606T2 (de) 2004-02-19
DE69812606T8 (de) 2005-03-10

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