US5597579A - Blends of absorbable polyoxaamides - Google Patents
Blends of absorbable polyoxaamides Download PDFInfo
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- US5597579A US5597579A US08/611,532 US61153296A US5597579A US 5597579 A US5597579 A US 5597579A US 61153296 A US61153296 A US 61153296A US 5597579 A US5597579 A US 5597579A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/44—Polyester-amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
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- A—HUMAN NECESSITIES
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- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
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- C—CHEMISTRY; METALLURGY
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- C08G63/672—Dicarboxylic acids and dihydroxy compounds
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G69/40—Polyamides containing oxygen in the form of ether groups
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/12—Polyester-amides
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D167/00—Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chain; Coating compositions based on derivatives of such polymers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Definitions
- the present invention is a continuation-in-part of Ser. No. 08/554,614, filed Nov. 6, 1995, now abandoned, which is a continuation-in-part of Ser. No. 08/399,308, filed Mar. 6, 1995, now U.S. Pat. No. 5,464,929 (all hereby incorporated by reference herein) and relates to a polymeric material and more particularly to absorbable products made from polyoxaamides and blends thereof with other polymers.
- aromatic polyester particularly poly(ethylene terephthalate) have become the most commercial important polyesters.
- the usefulness of these polymers is intimately linked to the stiffening action of the p-phenylene group in the polymer chain.
- the presence of the p-phenylene group in the backbone of the polymer chain leads to high melting points and good mechanical properties especially for fibers, films and some molded products.
- poly(ethylene terephthalate) has become the polymer of choice for many common consumer products, such as one and two liter soft drink containers.
- polylactones such as polylactide, polyglycolide, poly(p-dioxanone) and polycaprolactone. These aliphatic polylactones have been used primarily for bioabsorbable surgical sutures and surgical devices such as staples. Although polylactones have proven to be useful in many applications they do not meet all the needs of the medical community. For example films of polylactones do not readily transmit water vapor, therefore, are not ideally suited for use as bandages where the transmission of water vapor would be desired.
- aliphatic polyoxaamides which includes polyoxaesteramides
- blends thereof with other polymers that may be used in surgical devices such as sutures, molded devices, drug delivery matrices, coatings, lubricants and the like.
- the aliphatic polyoxaamides of the present invention are polymers comprising a first divalent repeating unit of formula I:
- X and Y are selected from the group consisting of --O-- and --N(R)--, provided that X and Y cannot both be --O--;
- R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms;
- R 3 is selected from the group consisting of an alkylene unit and an oxyalkylene group of the following formula:
- C is an integer in the range of from 2 to about 5
- D is an integer in the range of from 0 to about 2,000
- E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to about 12
- R 17 is a alkylene unit containing from 2 to 8 carbon atoms which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or an internal --C(O)--N(R 21 )---
- T is an integer in the range of from 1 to about 2,000 and preferably is in the range of from 1 to about 1,000
- R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms
- R 5 and R 9 are selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H
- the aliphatic polyoxaamides (which also includes polyoxaesteramides that are within the scope of the present invention) of the present invention are the reaction product of 1) an aliphatic polyoxydicarboxylic acid and a diamine or amino alcohol optionally containing one of the following compounds: a diol (or polydiol), a lactone (or lactone oligomer), a coupling agent or combination thereof.
- Suitable aliphatic alpha-oxydicarboxylic acids for use in the present invention generally have the following formula:
- R, R 1 and R 2 are independently selected from the group consisting of hydrogen and an alkyl group containing from 1 to 8 carbon atoms and R 3 is an alkylene containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:
- C is an integer in the range of from about 2 to about 5
- D is an integer in the range of from 0 to about 2,000 and preferably 1 to about 12
- E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be an integer in the range of from 2 to 12.
- Suitable amino alcohols, diamines, diols or polydiols for use in the present invention have repeating units with up to 8 carbon atoms having the formulas:
- R 13 , R 15 , R 4 and R 19 are independently alkylene units containing from 2 to 8 methylene units which may have substituted therein an internal ether oxygen, an internal --N(R 18 )-- or internal --C(O)--N(R 21 )--;
- R 18 and R 21 are independently selected from the group consisting of hydrogen and an alkyl group containing 1 to 8 carbon atoms;
- R 12 , R 14 , R 16 and R 20 are independently selected from the group consisting of hydrogen, alkyl group containing from 1 to 8 carbon atoms and mixtures thereof;
- A, U, V and Z are independently integers in the range of from 1 to about 2,000 and preferably from 1 to 1,000.
- suitable amino alcohols include amino alcohols selected from the group consisting of ethanol amine, isopropanol amine, 3-amino-1-propanol, 4-amino-1-butanol, 4-amino-2-butanol, 2-amino-1-butanol and 2-(2-aminoethoxy)ethanol.
- suitable diamines include diamines selected from the group consisting of ethylene diamine, 1,2-diaminopropane, 1,3-diaminopropane, 1,4-diaminobutane, 1,4-diaminocyclohexane and 1,5-diamino-3-oxapentane.
- suitable diols include diols selected from the group consisting of 1,2-ethanediol (ethylene glycol), 1,2-propanediol (propylene glycol), 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol, 1,3-cyclopentanediol, 1,6-hexanediol, 1,4-cyclohexanediol, 1,8-octanediol and combinations thereof.
- 1,2-ethanediol ethylene glycol
- 1,2-propanediol propylene glycol
- 1,3-propanediol 1,4-butanediol
- 1,5-pentanediol 1,5-pentanediol
- 1,3-cyclopentanediol 1,6-hexanediol
- 1,4-cyclohexanediol 1,8-o
- polydiols examples include polydiols selected from the group consisting of polyethylene glycol (H[--O--CH 2 --CH 2 --] A OH) and polypropylene glycol (H[--O--CH 2 --CH(CH 3 )--] A OH).
- polymer produced by reacting the aliphatic dioxacarboxylic acid with the amino alcohols discussed above should provide a polymer generally having the formula:
- R 1 , R 2 , R 3 , R 12 , R 13 and U are as described above; and J is an integer in the range of from about 1 to about 10,000 and preferably is in the range of from about 10 to about 1,000 and most preferably in the range of from about 50 to about 200.
- the polymer produced by reacting the aliphatic dioxacarboxylic acid with the diamine discussed above should provide a polymer generally having the formula:
- R 1 , R 2 , R 3 , R 14 , R 15 , R 16 V and J are as described above.
- the polymer produced by reacting the aliphatic dioxacarboxylic acid with a mixture of aminoalcohols, diols and diamines discussed above should provide a polymer generally having end groups that may be active amines or hydroxyl groups.
- Suitable lactone monomers that may be used in the present invention generally have the formula: ##STR1##
- lactone monomers (or equivalent acids if any) may be polymerized to provide polymers of the following general structures:
- R 5 and R 9 are independently selected from the group consisting of --C(R 6 )(R 7 )--, --(CH 2 ) 3 --O--, --CH 2 --CH 2 --O--CH 2 --, --CR 8 H--CH 2 --, --(CH 2 ) 4 --, --(CH 2 ) F --O--C(O)-- and --(CH 2 ) K --C(O)--CH 2 --;
- R 6 and R 7 are independently selected from the group consisting of hydrogen and an alkyl containing from 1 to 8 carbon atoms;
- R 8 is selected from the group consisting of hydrogen and methyl;
- F and K are integers in the range of from 2 to 6;
- B is an integer in the range of from 1 to n such that the number average molecular weight of formula IX is less than about 200,000, preferably less than about 100,000, more preferably less than about 40,000 and most preferably less than 20,000;
- P is an integer in the range of from 1 to m such that the
- G will be the residue of a dihydroxy alcohol minus both hydroxyl groups.
- Suitable lactone-derived repeating units may be generated from the following monomers include but are not limited to lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ⁇ -caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
- the polymer formed by reacting the above described amino alcohols, diamines, and diol (or polydiol) VI with the appropriate aliphatic oxadicarboxylic acid or aliphatic polyoxydicarboxylic acid V may also be copolymerized in a secondary ring-opening polymerization with the lactone monomers XIII or in a condensation copolymerization with the lactone oligomers IX or X, described above to form a polymer generally of the formula: ##STR2## wherein X and Y are selected from the group consisting of --O-- and N(R), provided that X and Y cannot both be --O--; and S is an integer in the range of from about 1 to about 10,000 and is preferably an integer in the range of from about 1 to about 1,000 and W is an integer in the range of from about 1 to about 1,000.
- These polymers may be made in the form of random copolymers or block copolymers.
- a coupling agent selected from the group consisting of trifunctional or tetrafunctional polyols, oxycarboxylic acids, and polybasic carboxylic acids (or acid anhydrides thereof).
- the addition of the coupling agents causes the branching of long chains, which can impart desirable properties in the molten state to the polyester prepolymer.
- Suitable polyfunctional coupling agents include trimethylol propane, glycerin, pentaerythritol, malic acid, citric acid, tartaric acid, trimesic acid, propane tricarboxylic acid, cyclopentane tetracarboxylic anhydride, triethanol amine and combinations thereof.
- the amount of coupling agent to be added before gelation occurs is a function of the type of coupling agent used and the polymerization conditions of the polyoxaamide or molecular weight of the prepolymer to which it is added. Generally in the range of from about 0.1 to about 10 mole percent of a trifunctional or a tetrafunctional coupling agent may be added based on the moles of aliphatic polyoxaamide polymers present or anticipated from the synthesis.
- the preparation of the aliphatic polyoxaamides are preferably polymerizations performed under melt polycondensation conditions at elevated temperatures. At times it may be preferably to add a catalyst such as an organometallic compound.
- a catalyst such as an organometallic compound.
- Preferred organometallic catalysts are tin-based catalysts e.g. stannous octoate.
- the catalyst will preferably be present in the mixture at a mole ratio of hydroxy groups, aliphatic polyoxydicarboxylic acid and optionally lactone monomer to catalyst will be in the range of from about 5,000 to about 80,000/1.
- the reaction is preferably performed at a temperature no less than about 120° C. under reduced pressure.
- the reaction mixture will be maintained at about 220° C.
- the polymerization reaction can be allowed to proceed at this temperature until the desired molecular weight and percent conversion is achieved for the copolymer, which will typically take about 15 minutes to 24 hours.
- Increasing the reaction temperature generally decreases the reaction time needed to achieve a particular molecular weight, but may also increase the extent of side reactions. We have found that reaction at about 220° C. to be generally suitable.
- aliphatic polyoxaamide copolymers can be prepared by forming an aliphatic polyoxaamide prepolymer polymerized under melt polycondensation conditions, then adding at least one lactone monomer or lactone prepolymer. The mixture would then be subjected to the desired conditions of temperature and time to copolymerize the prepolymer with the lactone monomers. If a lactone prepolymer is used, a polycondensation reaction can be used to increase the molecular weight.
- the molecular weight of the prepolymer as well as its composition can be varied depending on the desired characteristic which the prepolymer is to impart to the copolymer. However, it is preferred that the aliphatic polyoxaamide prepolymers from which the copolymer is prepared have a molecular weight that provides an inherent viscosity between about 0.2 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol at 25° C. Those skilled in the art will recognize that the aliphatic polyoxaamide prepolymers described herein can also be made from mixtures of more than one diol, amino alcohol, or dioxacarboxylic acid.
- the ester linkages are hydrolytically unstable, and therefore the polymer is bioabsorbable because it readily breaks down into small segments when exposed to moist bodily tissue.
- co-reactants could be incorporated into the reaction mixture of the aliphatic dioxacarboxylic acid and the diol for the formation of the aliphatic polyoxaamide prepolymer, it is preferable that the reaction mixture does not contain a concentration of any co-reactant which would render the subsequently prepared polymer nonabsorbable.
- the reaction mixture is substantially free of any such co-reactants if the resulting polymer is rendered nonabsorbable.
- the other polymers which the aliphatic polyoxaamides may be blended with include but are not limited to homopolymer and copolymer of lactone type polymers with the repeating units described by Formula VIII, polyesters (such as adipates) aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers (such as ethylene-vinyl acetate copolymers and ethylene ethyl acrylate copolymers), polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate).
- polyesters such as adipates
- polyether polyurethanes such as ethylene-vinyl acetate copolymers and ethylene ethyl acrylate copolymers
- the copolymers including random, block and segmented copolymers.
- Suitable lactone-derived repeating units may be generated from the following monomers include but are not limited to lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, meso-lactide, ⁇ -caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
- the blends may contain about 1 weight percent to about 99 weight percent of the aliphatic polyoxaamides.
- additive ingredients such as stabilizers, antioxidants radiopacifiers, fillers or the like.
- the aliphatic polyoxaamide and other polymers may be blended using conventional mixing processes known in the art.
- a blend can be prepared using a two-roll mill, an internal mixer (such as a Brabender or Banbury mixer), an extruder (such as a twin screw extruder) or the like.
- the polymer blends of this invention can be melt processed by numerous methods to prepare a vast array of useful devices. These polymer blends can be injection or compression molded to make implantable medical and surgical devices, especially wound closure devices.
- the preferred wound closure devices are surgical clips, staples and sutures.
- the polymer blends can be extruded to prepare fibers.
- the filaments thus produced may be fabricated into sutures or ligatures, attached to surgical needles, packaged, and sterilized by known techniques.
- the polymers of the present invention may be spun as multifilament yarn and woven or knitted to form sponges or gauze, (or non-woven sheets may be prepared) or used in conjunction with other molded compressive structures as prosthetic devices within the body of a human or animal where it is desirable that the structure have high tensile strength and desirable levels of compliance and/or ductility.
- Useful embodiments include tubes, including branched tubes, for artery, vein or intestinal repair, nerve splicing, tendon splicing, sheets for typing up and supporting damaged surface abrasions, particularly major abrasions, or areas where the skin and underlying tissues are damaged or surgically removed.
- polymer blends can be molded to form films which, when sterilized, are useful as adhesion prevention barriers.
- Another alternative processing technique for the polymer blends of this invention includes solvent casting, particularly for those applications where a drug delivery matrix is desired.
- the surgical and medical uses of the filaments, films, and molded articles of the present invention include, but are not necessarily limited to:
- Knitted products, woven or non-woven, and molded products including:
- k. clips e.g., for vena cava
- n. bone substitutes e.g., mandible prosthesis
- o. intrauterine devices e.g., spermicidal devices
- the polymer blends can be used to coat a surface of a surgical article to enhance the lubricity of the coated surface.
- the polymer blends may be applied as a coating using conventional techniques.
- the polymer blends may be solubilized in a dilute solution of a volatile organic solvent, e.g. acetone, methanol, ethyl acetate or toluene, and then the article can be immersed in the solution to coat its surface.
- a volatile organic solvent e.g. acetone, methanol, ethyl acetate or toluene
- the polymer blends should exhibit an inherent viscosity, as measured in a 0.1 gram per deciliter (g/dl) of hexafluoroisopropanol (HFIP), between about 0.05 to about 2.0 dl/g, preferably about 0.10 to about 0.80 dl/g. If the inherent viscosity were less than about 0.05 dl/g, then the polymer blends may not have the integrity necessary for the preparation of films or coatings for the surfaces of various surgical and medical articles. On the other hand, although it is possible to use polymer blends with an inherent viscosity greater than about 2.0 dl/g, it may be exceedingly difficult to do so.
- HFIP hexafluoroisopropanol
- the preferred surgical articles are surgical sutures and needles.
- the most preferred surgical article is a suture, most preferably attached to a needle.
- the suture is a synthetic absorbable suture.
- These sutures are derived, for example, from homopolymers and copolymers of lactone monomers such as glycolide, lactide, ⁇ -caprolactone, 1,4-dioxanone, and trimethylene carbonate.
- the preferred suture is a braided multifilament suture composed of polyglycolide or poly(glycolide-co-lactide).
- the amount of polymer blend to be applied on the surface of a braided suture can be readily determined empirically, and will depend on the particular copolymer and suture chosen. Ideally, the amount of polymer blend applied to the surface of the suture may range from about 0.5 to about 30 percent of the weight of the coated suture, more preferably from about 1.0 to about 20 weight percent, most preferably from 1 to about 5 weight percent. If the amount of coating on the suture were greater than about 30 weight percent, then it may increase the risk that the coating may flake off when the suture is passed through tissue.
- Sutures coated with the polymer blends of this invention are desirable because they have a more slippery feel, thus making it easier for the surgeon to slide a knot down the suture to the site of surgical trauma.
- the suture can be passed more easily through body tissue thus reducing tissue trauma.
- the amount of coating applied to the surface of the article is an amount which creates a layer with a thickness ranging preferably between about 2 to about 20 microns on the needle, more preferably about 4 to about 8 microns. If the amount of coating on the needle were such that the thickness of the coating layer was greater than about 20 microns, or if the thickness was less than about 2 microns, then the desired performance of the needle as it is passed through tissue may not be achieved.
- the polymer blends can be used as a pharmaceutical carrier in a drug delivery matrix.
- the polymer blends would be mixed with a therapeutic agent to form the matrix.
- the variety of different therapeutic agents which can be used in conjunction with the polymer blends of the present invention is vast.
- therapeutic agents which may be administered via the pharmaceutical compositions of the invention include, without limitation: antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; anorexics; antihelmintics; antiarthritics; antiasthmatic agents; anticonvulsants; antidepressants; antidiuretic agents; antidiarrheals; antihistamines; antiinflammatory agents; antimigraine preparations; antinauseants; antineoplastics; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics, antispasmodics; anticholinergics; sympathomimetics; xanthine derivatives; cardiovascular preparations including calcium channel blockers and beta-blockers such as pindolol and antiarrhythmics; antihypertensives; diuretics; vasodilators including general coronary, peripheral and cerebral; central nervous system stimulants; cough and cold preparations, including decongestants; hormones such as estradio
- the drug delivery matrix may be administered in any suitable dosage form such as oral, parenteral, a subcutaneously as an implant, vaginally or as a suppository.
- Matrix formulations containing the polymer blends may be formulated by mixing one or more therapeutic agents with the blends.
- the therapeutic agent may be present as a liquid, a finely divided solid, or any other appropriate physical form.
- the matrix will include one or more additives, e.g., nontoxic auxiliary substances such as diluents, carriers, excipients, stabilizers or the like.
- additives e.g., nontoxic auxiliary substances such as diluents, carriers, excipients, stabilizers or the like.
- Other suitable additives may be formulated with the blends and pharmaceutically active agent or compound, however, if water is to be used it should be added immediately before administration.
- the amount of therapeutic agent will be dependent upon the particular drug employed and medical condition being treated. Typically, the amount of drug represents about 0.001% to about 70%, more typically about 0.001% to about 50%, most typically about 0.001% to about 20% by weight of the matrix.
- the quantity and type of polymer blends incorporated into the parenteral will vary depending on the release profile desired and the amount of drug employed.
- the product may contain blends of polymers of different molecular weights to provide the desired release profile or consistency to a given formulation.
- the polymer blends upon contact with body fluids including blood or the like, undergoes gradual degradation (mainly through hydrolysis) with concomitant release of the dispersed drug for a sustained or extended period (as compared to the release from an isotonic saline solution). This can result in prolonged delivery (over, say 1 to 2,000 hours, preferably 2 to 800 hours) of effective amounts (say, 0.0001 mg/kg/hour to 10 mg/kg/hour) of the drug.
- This dosage form can be administered as is necessary depending on the subject being treated, the severity of the affliction, the judgment of the prescribing physician, and the like.
- a drug could be formulated with a polyoxaamide and orally administered to an animal.
- the drug release profile could then be monitored by appropriate means such as, by taking blood samples at specific times and assaying the samples for drug concentration. Following this or similar procedures, those skilled in the art will be able to formulate a variety of formulations.
- the polymers, copolymers and blends of the present invention can be crosslinked to affect mechanical properties.
- Crosslinking can be accomplished by the addition of crosslinking enhancers and/or irradiation (such as gamma-irradiation).
- crosslinking can be used to control the water swellablity of said invention.
- the polyoxaamide polymers and polymer blends of the present invention can be used in tissue engineering applications as supports for cells.
- Appropriate tissue scaffolding structures are known in the art such as the prosthetic articular cartilage described in U.S. Pat. No. 5,306,311, the porous biodegradable scaffolding described in WO 94/25079, and the prevascularized implants described in WO 93/08850 (all hereby incorporated by reference herein).
- Methods of seeding and/or culturing cells in tissue scaffoldings are also known in the art such as those methods disclosed in EPO 422 209 B1, WO 88/03785, WO 90/12604 and WO 95/33821 (all hereby incorporated by reference herein).
- the diacid, 3,6-dioxaoctanedioic acid was synthesized by oxidation of triethylene glycol.
- the oxidation was carried out in a 500 milliliter, three-neck round bottom flask equipped with a thermometer, an additional funnel, a gas absorption tube and a magnetic spinbar.
- the reaction flask was lowered into an oil bath resting upon a magnetic stirrer.
- To the reaction flask was added 157.3 ml of a 60% nitric acid solution; 37.0 g of triethylene glycol was added to the additional funnel.
- the contents of the flask were heated to 78°-80° C.
- a test tube containing 0.5 g of glycol and one milliliter of concentrated nitric acid was warmed in a water bath until brown fumes started appearing. The contents were then added to the reaction flask. The mixture was stirred for a few minutes; the glycol was then carefully added. The rate of addition had to be monitored extremely carefully to keep the reaction under control. The addition rate was slow enough so that the temperature of the exothermic reaction mixture was maintained at 78°-82° C. After the addition was completed (80 minutes), the temperature of the reaction mixture was maintained at 78°-80° C. for an additional hour. While continuing to maintain this temperature range, the excess nitric acid and water was then distilled off under reduced pressure (water suction). The syrupy residue was cooled; some solids appeared. The reaction product had the IR and NMR spectra expected for the dicarboxylic acid; the crude product was used as such for esterification.
- the crude diacid could be purified to the extent needed for polymerization or alternately could be converted to the corresponding diester, the diester purified and subsequently hydrolyzed back to (purified) diacid.
- the diamine salts of the diacids are purified and then subsequently polymerized to form the polyoxaamides of the present invention.
- Esterification of the crude 3,6-dioxaoctanedioic acid was accomplished as follows: To the reaction flask containing 36 g of the crude diacid, was added 110 ml of methanol. This was stirred for 3 days at room temperature after which 15 g of sodium bicarbonate was added and stirred overnight. The mixture was filtered to remove solids. To the liquor was added an additional 10 g of sodium bicarbonate; this mixture was stirred overnight. The mixture was again filtered; the liquor was fractionally distilled. NMR analysis of the esterified product showed a mixture of dimethyl triglycolate (78.4 mole %) and monomethyltriglycolate (21.6 mole %). No significant condensation of diacid was observed.
- a flame dried, mechanically stirred, 50-milliliter glass reactor suitable for polycondensation reaction is charged with the equivalent of 0.1 mole of purified 3,6-dioxaoctanedioic acid from Example 1 (17.81 g), and 0.1 mole of ethanolamine (6.11 g).
- the polymerization can be conducted without additional catalyst or alternately a small amount of catalyst (e.g. 0.0606 ml of a solution of 0.33M stannous octoate in toluene) can be added.
- the temperature is gradually raised over the course of 26 hours to 180° C.
- a temperature of 180° C. is then maintained for another 20 hours; all during these heating periods under nitrogen at one atmosphere, the water formed is collected.
- the reaction flask is allowed to cool to room temperature; it is then slowly heated under reduced pressure (0.015-1.0 mm) over the course of about 32 hours to 160° C., during which time additional distillates can be collected.
- a temperature of 160° C. is maintained for 4 hours after which a sample, a few grams in size, of the polymer formed is taken.
- the sample is found to have an inherent viscosity (I.V.) of approximately 0.2 dl/g, as determined in hexaflouroisopropanol (HFIP) at 25° C. at a concentration of 0.1 g/dl.
- I.V. inherent viscosity
- the polymerization is continued under reduced pressure while raising the temperature, in the course of about 16 hours, from 160° C. to 180° C.; a temperature of 180° C. is maintained for an additional 8 hours, at which time a polymer sample is taken and found to have an I.V. of approximately 0.3 dl/g.
- the reaction is continued under reduced pressure for another 8 hours at 180° C.
- the resulting polymer should have an inherent viscosity of approximately 0.4 dl/g, as determined in HFIP at 25° C. and at a concentration of 0.1 g/dl.
- a flame dried, mechanically stirred, 250-milliliter glass reactor, suitable for polycondensation reaction, is charged with the equivalent of 0.2 mole (44.44 g) of 3,6,9-trioxaundecanedioic acid, and 0.2 mole (12.02 g) of ethylene diamine; this can be conveniently done by charging the reactor with the stoichometric salt formed between the diacid and the diamine. Alternately a small excess of ethylene glycol can be substituted for a portion of the diamine.
- the polymerization can be conducted without additional catalyst or alternately a small amount of catalyst (e.g. 0.0606 ml of a solution of 0.33M stannous octoate in toluene or 10 milligrams of dibutyltin oxide) can be added.
- the contents of the reaction flask are gradually heated under nitrogen at one atmosphere, in the course of about 32 hours, to 180° C., during which time the water formed is collected.
- the reaction mass is allowed to cool to room temperature.
- the reaction mass is then heated under reduced pressure (0.015-1.0 mm), gradually increasing the temperature to 180° C. in about 40 hours; during this time additional distillates is collected.
- the polymerization is continued under reduced pressure while maintaining 180° C. for an additional 16 hours.
- the resulting polymer should have an inherent viscosity of approximately 0.5 dl/g as determined in HFIP at 25° C. and at a concentration of 0.1 g/dl.
- a flame dried, mechanically stirred, 500-milliliter glass reactor (suitable for polycondensation reaction) is charged with the equivalent of 0.2 mole (123.8 g) of polyglycol diacid (molecular weight about 619), and 0.2 mole (117.7 g) of Jeffamine (amine terminated polyethylene oxide).
- a small excess of ethylene glycol can be substituted for a portion of the diamine.
- the polymerization can be conducted without additional catalyst or alternately a small amount of catalyst.
- the contents of the reaction flask is heated under nitrogen at one atmosphere, gradually increasing the temperature to 200° C. in about 32 hours; during this time the water formed is collected.
- the reaction flask is heated gradually under reduced pressure (0.015-1.0 mm) from room temperature to 140° C. in about 24 hours, during which time additional distillates are collected.
- a polymer sample of about ten grams is taken at this stage, and found to have an I.V. of approximately 0.1 dl/g in HFIP at 25° C., 0.1 g/dl.
- the polymerization is continued under reduced pressure while heating from 140° C. to 180° C. in about 8 hours, and then maintained at 180° C. for an additional 8 hours.
- the reaction temperature is then increased to 190° C. and maintained there under reduced pressure for an additional 8 hours.
- the resulting polymer should have an inherent viscosity of approximately 0.6 dl/g as determined in HFIP at 25° C. and at a concentration of 0.1 g/dl.
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Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
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US08/611,532 US5597579A (en) | 1995-03-06 | 1996-03-05 | Blends of absorbable polyoxaamides |
US08/695,158 US5645850A (en) | 1995-03-06 | 1996-08-07 | Blending containing absorbable polyoxaamides |
US08/744,609 US5962023A (en) | 1995-03-06 | 1996-11-06 | Hydrogels containing absorbable polyoxaamides |
EP97301423A EP0794211B1 (de) | 1996-03-05 | 1997-03-04 | Absorbierbare Polyoxaamide enthaltende Mischungen |
AU15075/97A AU1507597A (en) | 1996-03-05 | 1997-03-04 | Blends containing absorbable polyoxaamides |
DE69734905T DE69734905T2 (de) | 1996-03-05 | 1997-03-04 | Absorbierbare Polyoxaamide enthaltende Mischungen |
CA002199079A CA2199079A1 (en) | 1996-03-05 | 1997-03-04 | Blends of absorbable polyoxaamides |
ZA971868A ZA971868B (en) | 1996-03-05 | 1997-03-04 | Blends of absorbable polyoxaamides |
MX9701690A MX9701690A (es) | 1996-03-05 | 1997-03-05 | Mezclas que contienen polioxaamidas absorbibles. |
CN97110090A CN1167126A (zh) | 1996-03-05 | 1997-03-05 | 含有可吸收的聚氧杂酰胺的共混物 |
JP9065569A JPH107793A (ja) | 1996-03-05 | 1997-03-05 | 吸収性ポリオキサアミド含有ブレンド物 |
BR9701197A BR9701197A (pt) | 1996-03-05 | 1997-03-05 | Misturas contendo polioxaamidas absorvíveis |
US09/062,814 US6100346A (en) | 1995-03-06 | 1998-04-20 | Copolymers of polyoxaamides |
US09/365,449 US6251435B1 (en) | 1995-03-06 | 1999-08-02 | Hydrogels containing absorbable polyoxaamides |
US09/829,615 US6458385B2 (en) | 1995-03-06 | 2001-04-10 | Hydrogels containing absorbable polyoxaamides |
US09/847,788 US6372256B2 (en) | 1995-03-06 | 2001-05-02 | Hydrogels containing absorbable polyoxaamides |
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Application Number | Priority Date | Filing Date | Title |
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US08/399,308 US5464929A (en) | 1995-03-06 | 1995-03-06 | Absorbable polyoxaesters |
US55461495A | 1995-11-06 | 1995-11-06 | |
US08/611,532 US5597579A (en) | 1995-03-06 | 1996-03-05 | Blends of absorbable polyoxaamides |
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US55461495A Continuation-In-Part | 1995-03-06 | 1995-11-06 | |
US59836296A Continuation-In-Part | 1995-03-06 | 1996-02-08 |
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US08/695,158 Division US5645850A (en) | 1995-03-06 | 1996-08-07 | Blending containing absorbable polyoxaamides |
US08/744,609 Continuation-In-Part US5962023A (en) | 1995-03-06 | 1996-11-06 | Hydrogels containing absorbable polyoxaamides |
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US08/695,158 Expired - Lifetime US5645850A (en) | 1995-03-06 | 1996-08-07 | Blending containing absorbable polyoxaamides |
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US08/695,158 Expired - Lifetime US5645850A (en) | 1995-03-06 | 1996-08-07 | Blending containing absorbable polyoxaamides |
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US (2) | US5597579A (de) |
EP (1) | EP0794211B1 (de) |
JP (1) | JPH107793A (de) |
CN (1) | CN1167126A (de) |
AU (1) | AU1507597A (de) |
BR (1) | BR9701197A (de) |
CA (1) | CA2199079A1 (de) |
DE (1) | DE69734905T2 (de) |
MX (1) | MX9701690A (de) |
ZA (1) | ZA971868B (de) |
Cited By (168)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0794211A2 (de) * | 1996-03-05 | 1997-09-10 | Ethicon, Inc. | Absorbierbare Polyoxaamide enthaltende Mischungen |
US5844017A (en) * | 1995-03-06 | 1998-12-01 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters containing amines and/or amido groups |
US5859150A (en) * | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
US5906617A (en) * | 1997-08-15 | 1999-05-25 | Meislin; Robert J. | Surgical repair with hook-and-loop fastener |
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Also Published As
Publication number | Publication date |
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CA2199079A1 (en) | 1997-09-05 |
DE69734905D1 (de) | 2006-01-26 |
DE69734905T2 (de) | 2006-09-14 |
EP0794211A2 (de) | 1997-09-10 |
JPH107793A (ja) | 1998-01-13 |
ZA971868B (en) | 1999-01-22 |
EP0794211A3 (de) | 1998-04-15 |
MX9701690A (es) | 1998-04-30 |
CN1167126A (zh) | 1997-12-10 |
US5645850A (en) | 1997-07-08 |
EP0794211B1 (de) | 2005-12-21 |
AU1507597A (en) | 1997-09-11 |
BR9701197A (pt) | 1998-12-15 |
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