US5070215A - Novel vinyl carbonate and vinyl carbamate contact lens material monomers - Google Patents
Novel vinyl carbonate and vinyl carbamate contact lens material monomers Download PDFInfo
- Publication number
- US5070215A US5070215A US07/346,204 US34620489A US5070215A US 5070215 A US5070215 A US 5070215A US 34620489 A US34620489 A US 34620489A US 5070215 A US5070215 A US 5070215A
- Authority
- US
- United States
- Prior art keywords
- mmol
- vinyl
- added
- vinyl carbonate
- trimethylsiloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000178 monomer Substances 0.000 title abstract description 77
- 239000000463 material Substances 0.000 title abstract description 51
- VAYTZRYEBVHVLE-UHFFFAOYSA-N 1,3-dioxol-2-one Chemical compound O=C1OC=CO1 VAYTZRYEBVHVLE-UHFFFAOYSA-N 0.000 title description 10
- LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 title description 6
- -1 trimethylsiloxy Chemical group 0.000 claims description 34
- RWEUKWCZWYHIQA-UHFFFAOYSA-N ethenyl 3-trimethylsilylpropyl carbonate Chemical compound C[Si](C)(C)CCCOC(=O)OC=C RWEUKWCZWYHIQA-UHFFFAOYSA-N 0.000 claims description 13
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000007983 Tris buffer Substances 0.000 claims description 7
- NPPNUGUVBUJRAB-UHFFFAOYSA-N 2-[tert-butyl(dimethyl)silyl]oxyethyl ethenyl carbonate Chemical compound CC(C)(C)[Si](C)(C)OCCOC(=O)OC=C NPPNUGUVBUJRAB-UHFFFAOYSA-N 0.000 claims description 6
- KZJNAICCMJTRKF-UHFFFAOYSA-N ethenyl 2-trimethylsilylethyl carbonate Chemical compound C[Si](C)(C)CCOC(=O)OC=C KZJNAICCMJTRKF-UHFFFAOYSA-N 0.000 claims description 6
- KRAZQXAPJAYYJI-UHFFFAOYSA-N ethenyl trimethylsilylmethyl carbonate Chemical compound C[Si](C)(C)COC(=O)OC=C KRAZQXAPJAYYJI-UHFFFAOYSA-N 0.000 claims description 5
- KLNBFEHQGRIYGL-UHFFFAOYSA-N 4-[[4-ethenoxycarbonyloxybutyl(dimethyl)silyl]oxy-dimethylsilyl]butyl ethenyl carbonate Chemical compound C=COC(=O)OCCCC[Si](C)(C)O[Si](C)(C)CCCCOC(=O)OC=C KLNBFEHQGRIYGL-UHFFFAOYSA-N 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims description 4
- 239000000017 hydrogel Substances 0.000 abstract description 38
- 229920001577 copolymer Polymers 0.000 abstract description 26
- 101100386054 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CYS3 gene Proteins 0.000 abstract 1
- 101150035983 str1 gene Proteins 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 100
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 100
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 98
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 91
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 84
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 80
- 239000011541 reaction mixture Substances 0.000 description 61
- 239000003921 oil Substances 0.000 description 60
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 54
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 53
- 239000002904 solvent Substances 0.000 description 50
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 49
- 235000019341 magnesium sulphate Nutrition 0.000 description 49
- PQLFROTZSIMBKR-UHFFFAOYSA-N ethenyl carbonochloridate Chemical compound ClC(=O)OC=C PQLFROTZSIMBKR-UHFFFAOYSA-N 0.000 description 43
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 42
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 41
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 41
- 229910052757 nitrogen Inorganic materials 0.000 description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 40
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 39
- 239000000741 silica gel Substances 0.000 description 39
- 229910002027 silica gel Inorganic materials 0.000 description 39
- 239000000203 mixture Substances 0.000 description 32
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 30
- 238000006243 chemical reaction Methods 0.000 description 29
- 239000012074 organic phase Substances 0.000 description 29
- 150000003254 radicals Chemical class 0.000 description 29
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 28
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 239000007787 solid Substances 0.000 description 24
- 239000012153 distilled water Substances 0.000 description 22
- 239000005457 ice water Substances 0.000 description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 20
- ILHMPZFVDISGNP-UHFFFAOYSA-N ethenyl n-[3-tris(trimethylsilyloxy)silylpropyl]carbamate Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCNC(=O)OC=C ILHMPZFVDISGNP-UHFFFAOYSA-N 0.000 description 19
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 18
- 239000003999 initiator Substances 0.000 description 18
- 229940073584 methylene chloride Drugs 0.000 description 18
- 238000003756 stirring Methods 0.000 description 17
- 239000004971 Cross linker Substances 0.000 description 15
- 239000012230 colorless oil Substances 0.000 description 15
- QMBPDUIWDIDECJ-UHFFFAOYSA-N (3-ethenoxycarbonyloxy-2,2-dimethylpropyl) ethenyl carbonate Chemical compound C=COC(=O)OCC(C)(C)COC(=O)OC=C QMBPDUIWDIDECJ-UHFFFAOYSA-N 0.000 description 14
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 11
- 239000003085 diluting agent Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- 239000002244 precipitate Substances 0.000 description 11
- 238000001816 cooling Methods 0.000 description 10
- 239000003431 cross linking reagent Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000004587 chromatography analysis Methods 0.000 description 9
- 239000007789 gas Substances 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- 239000002202 Polyethylene glycol Substances 0.000 description 8
- 235000019439 ethyl acetate Nutrition 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 238000009736 wetting Methods 0.000 description 7
- MBKCUZWFWVBTRD-UHFFFAOYSA-N ethenyl 1,1,1,3,3,3-hexafluoropropan-2-yl carbonate Chemical compound FC(F)(F)C(C(F)(F)F)OC(=O)OC=C MBKCUZWFWVBTRD-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000011953 free-radical catalyst Substances 0.000 description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- 239000012043 crude product Substances 0.000 description 5
- DPGXGQNEWAAUKM-UHFFFAOYSA-N ethenyl 2,2,2-trifluoroethyl carbonate Chemical compound FC(F)(F)COC(=O)OC=C DPGXGQNEWAAUKM-UHFFFAOYSA-N 0.000 description 5
- NYNPIIHFVAUZRG-UHFFFAOYSA-N ethenyl n-(2-hydroxyethyl)carbamate Chemical compound OCCNC(=O)OC=C NYNPIIHFVAUZRG-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 230000035699 permeability Effects 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- DNKKAFXSWPINLR-UHFFFAOYSA-N ethenyl (2,2,2-trifluoro-1-phenylethyl) carbonate Chemical compound C=COC(=O)OC(C(F)(F)F)C1=CC=CC=C1 DNKKAFXSWPINLR-UHFFFAOYSA-N 0.000 description 4
- NDXTZJDCEOXFOP-UHFFFAOYSA-N ethenyl 3-tris(trimethylsilyloxy)silylpropyl carbonate Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCOC(=O)OC=C NDXTZJDCEOXFOP-UHFFFAOYSA-N 0.000 description 4
- BHBDVHVTNOYHLK-UHFFFAOYSA-N ethenyl 3-tris(trimethylsilyloxy)silylpropylsulfanylformate Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCSC(=O)OC=C BHBDVHVTNOYHLK-UHFFFAOYSA-N 0.000 description 4
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 4
- 230000000379 polymerizing effect Effects 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- DDHUNHGZUHZNKB-UHFFFAOYSA-N 2,2-dimethylpropane-1,3-diamine Chemical compound NCC(C)(C)CN DDHUNHGZUHZNKB-UHFFFAOYSA-N 0.000 description 3
- XMBUKRXSRNUERW-UHFFFAOYSA-N 2-(2,5-dioxopyrrolidin-1-yl)ethyl ethenyl carbonate Chemical compound C=COC(=O)OCCN1C(=O)CCC1=O XMBUKRXSRNUERW-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- MMWCHSBIWFYBBL-UHFFFAOYSA-N 3-chloropropyl-tris(trimethylsilyloxy)silane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCCl MMWCHSBIWFYBBL-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000010779 crude oil Substances 0.000 description 3
- QIFSYKQMXBCHBM-UHFFFAOYSA-N ethenyl 2-hydroxyethyl carbonate Chemical compound OCCOC(=O)OC=C QIFSYKQMXBCHBM-UHFFFAOYSA-N 0.000 description 3
- GGMBDKOJGUPPOZ-UHFFFAOYSA-N ethenyl 3-(2-oxopyrrolidin-1-yl)propyl carbonate Chemical compound C=COC(=O)OCCCN1CCCC1=O GGMBDKOJGUPPOZ-UHFFFAOYSA-N 0.000 description 3
- RCTMPBPPPDIMPF-UHFFFAOYSA-N ethenyl n,n-diethylcarbamate Chemical compound CCN(CC)C(=O)OC=C RCTMPBPPPDIMPF-UHFFFAOYSA-N 0.000 description 3
- YWZHHIYHHGFQMK-UHFFFAOYSA-N ethenyl n-(3-amino-2,2-dimethylpropyl)-n-ethenoxycarbonylcarbamate Chemical compound NCC(C)(C)CN(C(=O)OC=C)C(=O)OC=C YWZHHIYHHGFQMK-UHFFFAOYSA-N 0.000 description 3
- 229940093476 ethylene glycol Drugs 0.000 description 3
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 3
- RKDZMXOMJLPVME-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) ethenyl carbonate Chemical compound C=COC(=O)ON1C(=O)CCC1=O RKDZMXOMJLPVME-UHFFFAOYSA-N 0.000 description 2
- RKXWQNOFLLZBGK-UHFFFAOYSA-N (5-ethenoxycarbonyloxy-2,2,3,3,4,4-hexafluoropentyl) ethenyl carbonate Chemical compound C=COC(=O)OCC(F)(F)C(F)(F)C(F)(F)COC(=O)OC=C RKXWQNOFLLZBGK-UHFFFAOYSA-N 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- WWLNLKMPGHBZDA-UHFFFAOYSA-N 2-[3-tris(trimethylsilyloxy)silylpropylamino]ethanol Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)CCCNCCO WWLNLKMPGHBZDA-UHFFFAOYSA-N 0.000 description 2
- ZJLIIWMZBBWQGW-UHFFFAOYSA-N 2-ethenoxycarbonyloxyethyl ethenyl carbonate Chemical compound C=COC(=O)OCCOC(=O)OC=C ZJLIIWMZBBWQGW-UHFFFAOYSA-N 0.000 description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical group CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 239000012267 brine Substances 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- ZQMIGQNCOMNODD-UHFFFAOYSA-N diacetyl peroxide Chemical compound CC(=O)OOC(C)=O ZQMIGQNCOMNODD-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- ZLRDPYFWCOSEHC-UHFFFAOYSA-N ethenyl 2-(2-oxopyrrolidin-1-yl)ethyl carbonate Chemical compound C=COC(=O)OCCN1CCCC1=O ZLRDPYFWCOSEHC-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 125000003827 glycol group Chemical group 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- XWLPYOYXFVQERN-UHFFFAOYSA-N n-methyl-3-tris(trimethylsilyloxy)silylpropan-1-amine Chemical compound CNCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C XWLPYOYXFVQERN-UHFFFAOYSA-N 0.000 description 2
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical group O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- ZTYVCUMMMHDLBR-UHFFFAOYSA-N tert-butyl ethenyl carbonate Chemical compound CC(C)(C)OC(=O)OC=C ZTYVCUMMMHDLBR-UHFFFAOYSA-N 0.000 description 2
- UHUUYVZLXJHWDV-UHFFFAOYSA-N trimethyl(methylsilyloxy)silane Chemical compound C[SiH2]O[Si](C)(C)C UHUUYVZLXJHWDV-UHFFFAOYSA-N 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- ZYYISNTZWVLFAO-UHFFFAOYSA-N (3-ethenoxycarbonyloxy-2-methylpropyl) prop-1-enyl carbonate Chemical compound CC=COC(=O)OCC(C)COC(=O)OC=C ZYYISNTZWVLFAO-UHFFFAOYSA-N 0.000 description 1
- STHAIEYZHGBQJQ-UHFFFAOYSA-N (4-butan-2-ylphenyl) ethenyl carbonate Chemical compound CCC(C)C1=CC=C(OC(=O)OC=C)C=C1 STHAIEYZHGBQJQ-UHFFFAOYSA-N 0.000 description 1
- GNOXTHAJEKVCLL-UHFFFAOYSA-N (4-tert-butylcyclohexyl) ethenyl carbonate Chemical compound CC(C)(C)C1CCC(OC(=O)OC=C)CC1 GNOXTHAJEKVCLL-UHFFFAOYSA-N 0.000 description 1
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
- WEPRPCKGOASICE-UHFFFAOYSA-N 1,3-bis(ethenoxycarbonyloxy)propan-2-yl ethenyl carbonate Chemical compound C=COC(=O)OCC(OC(=O)OC=C)COC(=O)OC=C WEPRPCKGOASICE-UHFFFAOYSA-N 0.000 description 1
- PWGJDPKCLMLPJW-UHFFFAOYSA-N 1,8-diaminooctane Chemical compound NCCCCCCCCN PWGJDPKCLMLPJW-UHFFFAOYSA-N 0.000 description 1
- TWYIPMITVXPNEM-UHFFFAOYSA-N 1-(2-hydroxyethyl)pyrrolidine-2,5-dione Chemical compound OCCN1C(=O)CCC1=O TWYIPMITVXPNEM-UHFFFAOYSA-N 0.000 description 1
- CVDGNRZPDAXOQO-UHFFFAOYSA-N 1-(3-hydroxypropyl)pyrrolidin-2-one Chemical compound OCCCN1CCCC1=O CVDGNRZPDAXOQO-UHFFFAOYSA-N 0.000 description 1
- SEZOCDHYMISSIN-UHFFFAOYSA-N 1-[tert-butyl(dimethyl)silyl]oxyethane-1,2-diol Chemical compound CC(C)(C)[Si](C)(C)OC(O)CO SEZOCDHYMISSIN-UHFFFAOYSA-N 0.000 description 1
- MDVGOOIANLZFCP-UHFFFAOYSA-N 1-adamantylmethanol Chemical compound C1C(C2)CC3CC2CC1(CO)C3 MDVGOOIANLZFCP-UHFFFAOYSA-N 0.000 description 1
- ZLTWIJREHQCJJL-UHFFFAOYSA-N 1-trimethylsilylethanol Chemical compound CC(O)[Si](C)(C)C ZLTWIJREHQCJJL-UHFFFAOYSA-N 0.000 description 1
- VNOMEAQPOMDWSR-UHFFFAOYSA-N 2,2,2-trifluoro-1-phenylethanol Chemical compound FC(F)(F)C(O)C1=CC=CC=C1 VNOMEAQPOMDWSR-UHFFFAOYSA-N 0.000 description 1
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- QDFJCVOKIBHLOY-UHFFFAOYSA-N 2-(ethenoxycarbonylamino)ethyl ethenyl carbonate Chemical compound C=COC(=O)NCCOC(=O)OC=C QDFJCVOKIBHLOY-UHFFFAOYSA-N 0.000 description 1
- LDLCZOVUSADOIV-UHFFFAOYSA-N 2-bromoethanol Chemical compound OCCBr LDLCZOVUSADOIV-UHFFFAOYSA-N 0.000 description 1
- ZLCKDYMZBZNBMJ-UHFFFAOYSA-N 2-bromoethyl carbonochloridate Chemical compound ClC(=O)OCCBr ZLCKDYMZBZNBMJ-UHFFFAOYSA-N 0.000 description 1
- BAEKOUPVFRFSMK-UHFFFAOYSA-N 2-bromoethyl ethenyl carbonate Chemical compound BrCCOC(=O)OC=C BAEKOUPVFRFSMK-UHFFFAOYSA-N 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0834—Compounds having one or more O-Si linkage
- C07F7/0838—Compounds with one or more Si-O-Si sequences
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F18/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
- C08F18/24—Esters of carbonic or haloformic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
- C08F218/24—Esters of carbonic or haloformic acids, e.g. allyl carbonate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F30/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
- C08F30/04—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
- C08F30/08—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Definitions
- Biomedical materials which are particularly useful as contact lens materials fall into three general classifications; hydrogels, non-hydrophilic soft materials and rigid gas permeable materials.
- contact lens hydrogels are almost completely described by polymer and copolymer systems comprised of either 2-hydroxyethylmethacrylate (HEMA) or N-vinyl-2-pyrrolidinone (NVP), or mixtures of HEMA and NVP. Minor components such as crosslinking agents are used in these systems to control tear strength, hydrolytic stability, modulus, etc.
- HEMA 2-hydroxyethylmethacrylate
- NVP N-vinyl-2-pyrrolidinone
- Minor components such as crosslinking agents are used in these systems to control tear strength, hydrolytic stability, modulus, etc.
- silicone based elastomers have also been known in the contact lens art for some time and have enjoyed limited commercial success.
- silicone chemistries involve vinyl functional end capped polysiloxane polymers.
- Rigid gas permeable contact lens materials are generally copolymers formed from copolymerizing acrylic or methacryl functional monomers which contain siloxane functionalities and often also contain fluorine atoms.
- the present invention provides a novel monomer chemistry to the art of biomedical device materials.
- the present invention provides novel monomers useful in biomedical devices. These novel monomers have the general formula ##STR2## where b is 0 or 1, a is 1, 2, 3 or 4, R 2 is a monovalent alkyl radical and R is an organic radical.
- the novel monomers may be employed to produce novel copolymers useful as hydrogel, soft non-hydrogel and/or rigid gas permeable contact lens materials.
- the present invention is directed to new crosslinked copolymers which employ novel monomers also disclosed in this application. These novel copolymers are particularly useful as biomedical materials, and are especially useful in the area of contact lens applications. These new crosslinked copolymers, when used in contact lens applications, can produce a wide variety of types of contact lens materials ranging from hard, gas permeable lens materials; soft, hydrogel lens materials; to soft, non-hydrogel lens materials.
- novel monomers generally fall into the following classifications: a) hydrophilic monomers with the general formula ##STR3## where b is 0 or 1; a is 1, 2, 3 or 4
- X denotes --NH--, --S-- or --O--;
- R H denotes a hydrophilic moiety such as an organic radical with one or more amide hydroxyl, urea or carboxylic acid functionalities so that the monomer as a whole is relatively hydrophilic;
- non- or slightly hydrophilic monomers of the general formula ##STR5## where a, b and X are as defined above and R NH denote a non-hydrophilic organic radical.
- hydrogel materials should have oxygen permeabilities with DK's greater than 20 ⁇ 10 -11 cm 3 ⁇ cm/sec. ⁇ cm 2 ⁇ mmHg (or DK units hereinafter) and preferably greater than 40 DK and most preferably greater than 60 DK. They should have a Young's modulus of elasticity in the range of 20 to 400 g/mm 2 , preferably 50 to 200 g/mm 2 as measured by ASTM test method D 638. They should have tear strengths greater than 1 g/mm 2 and preferably greater than 5 g/mm 2 as measured by ASTM test method D 1938.
- Their water content should be between 10 to 80%, and preferably between 20 to 50%.
- the contact angle which is a measurement of the wettability of the lens, should be less than 80° and should preferably be less than 40°.
- the protein uptake of hydrogel lenses or hydrogel lens materials should be less than or equivalent to that of PHEMA.
- Soft, non-hydrogel materials should have at a minimum oxygen permeabilities equal to or greater than hydrogel materials.
- the water content should always be less than 10%, and preferably less than 5%.
- the modulus of elasticity should be between 20 and 5,000 g/mm 2 and preferably should be in the range of 50 to 250 g/mm 2 .
- Contact angle less than 80° and preferably less than 40° and the tear strength (both initial and propagation) of this material should be in excess of 5 g/mm 2 .
- properties of hard, gas permeable lens materials should be similar to that of the hydrogel and the soft, non-hydrogel materials.
- the glass transition temperature of such materials should be greater than 40° C. and preferably greater than 65° C.
- the modulus of the material should be greater than 50,000 g/mm 2 and preferably greater than 75,000 g/mm 2 .
- the following prepolymer formulations should be used: (a) between 25 and 90% of the prepolymer mixture should comprise a hydrophilic monomer portion. This portion will preferably comprise in part at least a hydrophilic monomer represented by the general formula ##STR6## where b is 0 or 1 and X is --S--, --O--, or --NR 3 -- and R h denotes a relatively hydrophilic moiety.
- This hydrophilic monomer portion may also include at least one of the hydrophilic monomers chosen from the group consisting of wetting monomers N-vinyl-2-pyrrolidinone, 2-hydroxyethyl vinyl carbonate, 2-hydroxyethyl vinyl carbamate, 3-(2-pyrrolidinon-1-yl)-propyl vinyl carbonate, 2-(2-pyrrolidinon-1-yl)ethyl vinyl carbonate, N-(vinyloxycarbonyloxy)pyrrolidin-2,5-dione, N-[vinyloxycarbonyloxyethyl]pyrrolidin-2,5-dione, N-vinylacetamide, N-methyl-N-vinylacetamide, N,N-dimethyl vinyl carbamate, N,N-diethyl vinyl carbamate.
- These monomers may, of course, comprise only a portion of the hydrophilic monomer portion of prepolymer mix which can further be comprised of other hydrophilic monomers.
- the hydrogel prepolymer formulation should also preferably contain (b) between 40 to 80 weight percent of a non- or weakly hydrophilic monomer as combination of monomers chosen from the group consisting of 3-[tris(tri-methylsiloxy)silyl]propyl vinyl carbonate, t-butyl vinyl carbonate, t-butyldimethylsiloxyethyl vinyl carbonate, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, 3-(vinyloxycarbonylthio)propyl[tris(trimethylsiloxy)]silane, 3-[tris(trimethylsiloxy)silyl]propyl allyl carbamate, t-butylphenyl vinyl carbamate.
- a non- or weakly hydrophilic monomer as combination of monomers chosen from the group consisting of 3-[tris(tri-methylsiloxy)silyl]propyl vinyl carbonate, t-butyl vinyl carbonate, t-
- hydrogel prepolymer compositions further comprise (c) between about 0.1 to 10% of a crosslinking agent, which may be chosen from a list of preferred crosslinking agents later disclosed in this application, or one of the crosslinking monomers known in the prior art as exemplified and/or taught in U.S. Pat. Nos. 4,060,678; 4,182,822; 4,267,295; 4,640,941 and/or 4,690,993.
- a crosslinking agent which may be chosen from a list of preferred crosslinking agents later disclosed in this application, or one of the crosslinking monomers known in the prior art as exemplified and/or taught in U.S. Pat. Nos. 4,060,678; 4,182,822; 4,267,295; 4,640,941 and/or 4,690,993.
- the amount of hydrophilic monomer used to prepare the hydrogel material in the present invention is adjusted within the above limits to give a water content in the hydrated hydrogel of from about 5 to approximately 80% by weight.
- the non- or weakly hydrophilic monomer content is adjusted within the stated limits to maximize other desirable properties such as oxygen permeability, modulus and/or tear strength.
- the quantity of the crosslinking monomer used to produce a hydrogel material is adjusted to maximize desirable properties such as water content, modulus, lens strength, and also aids in the hydrolytically stability of the final material.
- UV absorbing monomers or tinting monomers may also be added to enhance the properties of the final material.
- Hard lenses are prepared using: (I) one or more of the non-hydrophilic monomers of the present invention; (II) a crosslinking agent; (III) a small amount of a wetting monomer; and (IV) optionally other agents such as strengthening agents or UV absorbing or dye monomers.
- the three main components are used in the following ratios; the non-hydrophilic monomer component (I) is used in amounts of about 60 to about 95 weight percent, the crosslinking monomer (II) in amounts from 0.1 to 10 weight percent, and the wetting monomer (III) in amounts from about 1 to 20 weight percent.
- the content of the crosslinking agent is chosen to provide a dimensionally stable lens material resistant to breakage and stress crazing.
- the amount of wetting monomer used is adjusted within limits to provide sufficient wetting characteristics so as to maintain a stable tear film while at the same time keeping a sufficiently low water content.
- the non-hydrophilic monomers used to make the hard contact lens materials include one or more of the following monomers: 2,2,2-trifluoroethyl vinyl carbonate, 2,2,2-trifluoroethyl vinyl carbamate, 1,1,1,3,3,3-Hexafluoroprop-2-yl vinyl carbonate, 2,2,2-trifluoroethyl allyl carbonate, 2,2,2-trifluoro-1-phenylethyl vinyl carbonate, trimethylsilylmethyl vinyl carbonate, trimethylsilylethyl vinyl carbonate, 3-(trimethylsilyl)propyl vinyl carbonate, t-butyldimethylsiloxyethyl vinyl carbonate, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate, 3-[tris-(trimethylsiloxy)silyl]propyl vinyl carbamate, 3-(vinyloxycarboxylthio) propyl-[tris(trimethylsiloxy)silane].
- crosslinking agents used preferably to make hard contact lens materials include crosslinking agents known in the prior art as taught in the U.S. patents referenced supra, but most preferably crosslinking agents chosen from the group consisting of crosslinking monomers represented by the formula ##STR7## wherein: X denotes --S--, --O--, or --NH-- and at least one X denotes a --NH-- in formula B; b is 0 or 1;
- R c1 denotes a multivalent organic radical and a is 2, 3, or 4; and R x1 denotes a divalent organic radical.
- the preferred crosslinkers includes:
- the wetting monomers useful in hard contact lenses include N-vinylpyrrolidinone, 2-hydroxyethylmethacrylate, itaconic acid, methacrylic acid, N,N-diethylacrylamide, N,N-diethyl vinyl carbamate, N,N-dimethyl vinyl carbamate, N-Methyl-N-Vinyl acetamide, and all hydrophilic monomers listed in the hydrogel section supra.
- Soft, non-hydrogel contact lens materials with little or no water content can be prepared by polymerizing prepolymer mixtures with the following formulations: between 50 and 90 weight percent of non-hydrophilic monomers with the following general formula: ##STR9## where X denotes either --O--, --S-- or --NH--; and
- R NH represents an organic radical that is largely non-hydrophilic, and a is 1, 2, 3 or 4;
- R H the largely non-hydrophilic moiety in the above formula, is typically a monovalent radical--but it may be multivalent.
- the main functional requirement is that it is largely non-hydrophilic, generally nonreactive to free-radical vinyl addition reactions and may be incorporated into the above formula from a synthetic perspective.
- R NH may be described by the following formulae: ##STR10## where R 1 denotes a monovalent organic radical such as an alkyl radical with 1 to 6 carbon atoms, or a fluoroalkyl radical with 1 to 6 carbon atoms;
- R c1 denotes ##STR11##
- p 1 to 6;
- d is 1-200
- n 1, 2, 3 or 4
- the non-hydrophilic monomers specifically include 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate; 1,3-bis[4-(vinyloxycarbonyloxy)but-1-yl]tetramethyldisiloxane; 3-(trimethylsilyl)propyl vinyl carbonate; t-butyldimethylsiloxyethyl vinyl carbonate; trimethylsilylmethyl vinyl carbonate; trimethylsilylethyl vinyl carbonate; 2,2,2-trifluoroethyl vinyl carbonate; t-butyl vinyl carbonate; 3-[tris(trimethylsiloxy)silyl] propyl vinyl carbonate; 2,2,2-trifluoroethyl vinyl carbamate; 1,1,1,3,3,3-hexafluoro-2-propyl vinyl carbonate; 3-(vinyloxycarbonylthio)propyl-[tris(trimethylsiloxy)silane]; 3-[tris-(trimethylsiloxy)silyl
- the hydrophilic monomers used to produce the proper wetting conditions in combination with the soft non-hydrogel materials are selected from hydrophilic monomers used in contact lenses in general, including N-vinyl lactams e.g., N-vinyl pyrrolidinone; hydroxyalkyl acrylates and methacrylates such as 2-hydroxyethyl methacrylate (HEMA) and preferably, the hydrophilic vinyl carbonates and vinyl carbamates disclosed in this application such as hydroxyethyl vinyl carbonate; N,N-dimethyl vinyl carbamate; or N-hydroxyethyl vinyl carbamate; N-[vinyloxycarbonyloxyethyl]pyrrolidin-2,5-dione; and 3-(2-pyrrolidinon-1-yl)propyl vinyl carbonate.
- N-vinyl lactams e.g., N-vinyl pyrrolidinone
- hydroxyalkyl acrylates and methacrylates such as 2-hydroxyethyl
- Crosslinkers used for the soft, non-hydrogel contact lens materials include the crosslinkers known in the prior art such as methylene glycol dimethacrylate and divinylbenzene, but preferably are crosslinking agents described in the present application by formulas A, B and C.
- the preferred non-hydrophilic monomers are the long chain siloxane monomers of the present invention such as the so-called "V 2 D 25 " monomers.
- soft non-hydrogel prepolymer formulations include:
- copolymers of the present invention are formed by way of a free radical polymerization the details of which are generally known in the art.
- the various comonomers are chosen and combined, as required to form the desired final copolymers, and a free radical catalyst is added to the mixture.
- the mixture is then polymerized to form the desired copolymer.
- Free radical catalysts are known in the art and are mostly of two general types: heat initiated free radical catalysts, and photoinitiated free radical catalysts, more specifically, ultraviolet radiation initiated free radical catalysts.
- Heat initiated catalysts include peroxides such as 2,5-dimethyl-2,5-bis(2-ethylhexanoylperoxy) hexane (Lupersol 256TM Pennwalt Chemicals), bisisopropylperoxydicarbarate, acetylperoxide, lauroyl peroxide or benzoyl peroxide, photoinitiators include compounds such as 2-hydroxy-2-methyl-1-phenylpropan-1-one (DarocurTM, EM Chemicals), and the like.
- Diluents may be employed in the process of polymerizing the copolymers of the present invention in order to modify the resultant physical characteristics of the finished copolymer.
- the comonomer mixture used to produce a hydrogel like material may also include a portion of methylethylketone.
- the amount of diluent used should be less than 50 wt. %. In most cases, the diluent content will be less than 30 wt. %. In a particular copolymer system, the actual limit will be dictated by the solubility of the various comonomers in the diluent.
- the maximum amount of diluent which may be used will depend on the amount of swelling the diluent causes the final copolymers. Excessive swelling will or may cause the copolymer to collapse when the diluent is replaced with water upon hydration.
- Suitable diluents include ethyleneglycol; glycerine; liquid polyethyleneglycol; alcohols; alcohol/water mixtures; ethylene oxide/propylene oxide block copolymers; low molecular weight linear polyhydroxyethylmethacrylates; glycol esters of lactic acid; formamides; ketones; dialkylsulfoxides; butyl carbitol; and the like.
- X denotes an --O--, --S--, or --NR 3 -- divalent radical
- R 1 denotes an organic radical
- R 2 denotes --H or --CH 3 ;
- R 3 denotes --H, or a monovalent alkyl radical
- a is 1, 2, 3, or 4;
- b is 0 or 1.
- copolymers may also contain further additives such as wetting agents, tints, dyes, strengthening agents and the like to tailor specific material properties as desired.
- the copolymers of the present invention are useful as biomedical devices, and in particular, are well suited as contact lens materials.
- the copolymers can be formed into contact lenses by many of the techniques known in the art to be useful in contact lens production. For instance, prepolymer mixtures containing heat initiated free radical catalysts can be placed in polypropylene tubes which are then heat cured over time to form copolymeric rods which are then cut to form button shaped articles. These button shaped articles can then be lathed into contact lenses.
- the prepolymer mixture can be molded per the methods disclosed in U.S. Pat. Nos. 4,085,459 or 4,197,266.
- Spin casting techniques may also be used with the present materials and such methods as described in U.S. Pat. Nos. 3,408,429 and 3,496,254 can be so adopted to be useful with the present copolymers.
- FTIR (neat, capillary) 3500.56, 3477.38, 3379.94, 2960.20, 1805.29, 1753.69, 1650.79, 1558.65, 1540.44, 1506.71, 1481.33, 1455.89, 1388.72, 1373.25, 1299.19, 1244.25, 1154.19, 1067.30, 1015.59, 995.52, 969.77, 944.14, 913.44, 875.08, 859.65, 779.15, 717.53, 684.06, 666.45, 649.43.
- FTIR (neat, capillary) 2962.91, 1754.66, 1679.48, 1646.22, 1494.64, 1462.88, 1438.22, 1424.48, 1393.77, 1368.15, 1327.55, 1286.44, 1237.47, 1152.71, 1113.47, 1085.63, 1046.25, 1018.86, 979.70, 946.17, 894.98, 877.43, 853.32, 779.37, 735.01, 697.06, 650.86.
- the reaction mixture was filtered through 20.0 g of activated F20 alumina to give a light yellow oil.
- the oil was heated at 80° C. at 0.25 Torr for 31/2 hours to remove volatiles, giving 13.4 g (5.90 mmol, 49.4%) of a light yellow oil.
- FTIR nitrogen-activated fluorescent spectroscopy
- N is an average value that gives the polypropylene glycol moiety an average molecular weight of about 1000.
- N is an average value that gives the polyethylene glycol moiety an average molecular weight of about 1000.
- Soft hydrogel copolymers of the present invention were produced by copolymerizing a monomer of the formula ##STR57## with N-vinylpyrrolidinone (NVP), and the crosslinker monomer 1,5-bis-(vinyloxycarbonyloxy)-2,2,3,3,4,4-hexacluoropentane, in the presence of a nonreactive diluent and a UV irradiation, free radical initiator in the following weight ratios:
- These films were prepared by placing the prepolymer mixtures between glass plates separated by a Teflon® peripheral gasket and were UV irradiated for 2 hours. The samples were then prepared for physical characterization.
- Oxygen permeabilities were measured by the method reported by Relojo, M. et al in Contact and Intraocular Lens Medical Journal, Vol. 3, issued p. 27 (1977) and edge effects were accounted for per the methods described by Fatt, et al. in International Contact Lens Clinic, v. 14, p. 389 (1987).
- Water content is measured per a gravimetric method.
- Refractive index was measured per typical methods on hydrated samples using a refractometer.
- Hard, gas permeable contact lens materials were made using the novel vinylcarbonate functional monomers described herein by polymerizing 1,1,1,3,3,3-hexafluoroprop-2-yl vinyl carbonate (hfpvc) ##STR58## with a variety of hydrophilic monomers and crosslinkers, such as those known in the prior art and the preferred hydrophilic monomers and crosslinkers disclosed herein.
- Films were made by the general method described in the hydrogel film example.
- the films were polymerized from monomer mixtures with the following formulations.
- a series of films were made by the general film casting technique described in the hydrogel materials example except that prepolymer mixtures for the various films were employed as hereinafter disclosed.
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Abstract
Description
______________________________________ I. A. 25-90 wt % hydrophilic monomer, 2-hydroxy- ethyl vinyl carbamate; B. 10-30 wt % non- or weakly hydrophilic monomer 3-N-[tris(trimethylsiloxy)silylpropyl] vinyl carbamate; and C. 0.1-10 wt % crosslinker, 1,2-bis-(vinyloxy carbonyloxy)ethane. II. A.i) 25-90 wt % hydrophilic monomer 2-hydroxyethyl vinyl carbamate; and ii) 25-90 wt % hydrophilic monomer N-vinyl pyrrolidinone, where the combination of i and ii comprises between 25 to 90 wt % of the final prepolymer compositions. B. 10-90 wt % of non-, or weakly hydrophilic monomer t-butyldimethylsiloxyethyl vinyl carbamate; and C. 0.1-10 wt % crosslinker, α,ω-bis-(vinyloxy- carbonyl) polyethylene glycol. III. A. 25-90 wt % hydrophilic monomer, 3-(2-pyrroli- dinon-1-yl)propyl vinyl carbamate; B. 10-30 wt % weak or non-hydrophilic monomer, t-butyl vinyl carbamate; and C. 0.1-10 wt % crosslinker, α,ω-bis-(vinyloxy- carbonyl) polyethylene glycol. ______________________________________
______________________________________ I) 80 wt % V.sub.2 D.sub.25 ; 10 wt % N-vinyl-2-pyrrolidinone; 5 wt % 2,2,2-trifluoroethyl vinyl carbonate; and 5 wt % N-O-bis-(vinylcarbonyl)ethandamine. II) 60 wt % 3-(trimethylsiloxy)propyl vinyl carbonate; 30 wt % α,ω-bis(vinyloxycarbonyl) polyethylene glycol; 5 wt % 1,1,1,3,3,3-Hexafluoroprop-2-yl vinyl carbonate; and 5 wt % N-vinyl-N-methyl acetamide. III) 25 wt % 3-(trimethylsilyl)propyl vinyl carbonate; 64 wt % 3-[tris-(trimethylsiloxy)silyl]propyl vinyl carbamate; 10 wt % N-vinylpyrrolidinone; and 1 wt % 2,2-dimethyl-1,3-bis(vinyloxycarbonyloxy) propane. IV) 20 wt % t-butyldimethylsiloxyethyl vinyl carbonate; 70 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate; 9 wt % N-vinylpyrrolidinone; and 1 wt % 2,2-dimethyl-1,3-bis(vinyloxycarbonyloxy) propane. V) 20 wt % trimethylsilylethyl vinyl carbonate; 69 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate; 10 wt % N-vinylpyrrolidinone; and 1 wt % 2,2-dimethyl-1,3-bis(vinyloxycarbonyloxy) propane. ______________________________________
______________________________________ hydrophilic film # monomer NVP X-linkers % H.sub.2 O DK × 10.sup.-11 ______________________________________ 1 22.5 65.0 2.5 73 45 2 62.5 25.0 2.5 19 91 3 64.5 24.7 0.5 25 97 4 23.5 45.0 1.5 63 41 5 53.5 25.0 1.5 27 79 6 42.5 25.0 2.5 33 65 7 2.5 65.0 2.5 85 56 8 23.5 65.0 1.5 77 51 9 44.5 45.0 0.5 58 46 10 21.5 64.7 0.9 80 49 11 43.1 43.1 0.9 53 47 12 64.7 21.5 0.9 23 115 13 32.5 45.0 2.5 51 37 ______________________________________
______________________________________ Tear (initial/ Modulus Tensile Elongation propagation) Film (g/mm.sup.2) (g/mm.sup.2) % (g/mm.sup.2) ______________________________________ 1 38 15 60 1.4/1.0 2 970 170 130 52/52 3 203 77 330 56/56 4 52 28 70 1.4/1.4 5 370 100 160 30/30 6 262 72 90 17/17 7 27 7 42 --/-- 8 17 13 120 1.1/1.0 9 18 20 280 6.5/6.5 10 72 43 75 0.8/0.6 11 49 27 180 --/5.5 12 430 110 200 --/46 13 86 40 70 3.2/3.1 ______________________________________
______________________________________ film #14: 65 wt % hfpvc 30 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 5 wt % hfpdvc and about 0.5 wt % free radical initiator film #15: 65 wt % hfpvc 30 wt % 3[tris(trimethylsiloxy)silyl]propyl vinyl carbonate and 0.5 wt % free radical initiator film #16: 65 wt % hfpvc 30 wt % 3-[tris(trimethylsiloxy)silyl] propyl vinyl carbamate 4.0 wt % 2,2-dimethyl-1,3-bis(vinyloxycarbonyl- oxy)propane 0.5 wt % free radical initiator film #17: 60 wt % hfpvc 25 wt % 3[tris(trimethylsiloxy)silyl] propyl vinyl carbonate 5 wt % V.sub.2 D.sub.25 5 wt % 2,2-dimethyl-1,3-bis(vinyloxycarbonyl- oxy)propane 5 wt % N-vinyl-2-pyrrolidinone 0.5 wt % free radical initiator film #18: 60 wt % hfpvc 25 wt % 3[tris(trimethylsiloxy)silyl]propyl vinyl carbonate 5 wt % V.sub.2 D.sub.25 5 wt % hfpdvc 5 wt % N-vinyl-2-pyrrolidinone 0.5 wt % free radical initiator film #19: 60 wt % hfpvc 25 wt % 3-(vinyloxycarbonylthio)propyl-[tris (trimethylsiloxy)silane] 5 wt % V.sub.2 D.sub.25 5 wt % hfpdvc 5 wt % N-vinyl-2-pyrrolidinone 0.5 wt % free radical initiator film #20: 60 wt % hfpvc 25 wt % 3-tris(trimethylsiloxy) propylsilane allylcarbamate 5 wt % V.sub.2 D.sub.25 5 wt % 2,2,3,3,4,4-hexafluoro-1,5-pentane dinvinylcarbonate 5 wt % N-vinyl-2-pyrrolidinone 0.5 wt % free radical initiator ______________________________________
______________________________________ modulus tensile O2 Perm film # (g/mm.sup.2) (g/mm.sup.2) % elongation × 10.sup.-11 ______________________________________ 14 75000 1250 14 130 15 82000 1500 13 140 16 80000 2100 8 130 17 73000 2000 8 120 18 85000 1600 16 130 19 84000 1800 7 100 20 101000 2500 7 100 ______________________________________
______________________________________ film #21: 50 wt % 3-(trimethylsilyl)propyl vinyl carbonate 35 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 5 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #22: 25 wt % 3-(trimethylsilyl)propyl vinyl carbonate 64 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #23: 44 wt % 3-(trimethylsilyl)propyl vinyl carbonate 44 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10.5 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #24: 54 wt % 3-(trimethylsilyl)propyl vinyl carbonate 35 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #25: 65 wt % 3-(trimethylsilyl)propyl vinyl carbonate 25 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #26: 40 wt % 3-(trimethylsilyl)propyl vinyl carbonate 40 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 20 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #27: 34 wt % 3-(trimethylsilyl)propyl vinyl carbonate 34 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 30 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #28: 28 wt % 3-(trimethylsilyl)propyl vinyl carbonate 68 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 4 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-(vinyloxy- carbonyloxy)propane 0.5 wt % UV free radical initiator film #29: 20 wt % trimethylsilylmethyl vinyl carbonate 70 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-(vinyloxy- carbonyloxy)propane 0.5 wt % free radical initiator film #30: 20 wt % trimethylsilylethyl vinyl carbonate 70 wt % 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate 10 wt % N-vinyl-2-pyrrolidinone 1 wt % 2,2-dimethyl-1,3-bis(vinyloxy- carbonyloxy)propane 0.5 wt % free radical initiator ______________________________________
______________________________________ tensile % Tear Strength modulus strength elon- (initial/ O.sub.2 DK film # (g/mm.sup.2) (g/mm.sup.2) gation propagation) × 10.sup.-11 ______________________________________ 21 2200 440 106 120/120 76 22 270 150 234 80/80 140 23 143 140 266 70/70 100 24 120 140 270 70/70 90 25 110 120 270 80/80 72 26 35 40 210 14/14 56 27 50 70 290 30/30 80 28 400 120 200 100/100 110 29 -- -- -- -- 100 30 -- -- -- -- 100 ______________________________________
Claims (8)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/346,204 US5070215A (en) | 1989-05-02 | 1989-05-02 | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
CA002014210A CA2014210C (en) | 1989-05-02 | 1990-04-09 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
IE138490A IE81155B1 (en) | 1989-05-02 | 1990-04-18 | Copolymers of vinyl carbonate and vinyl carbamate as contact lens material |
JP11066490A JP3274681B2 (en) | 1989-05-02 | 1990-04-27 | New vinyl carbonate and vinyl carbamate contact lens material monomers |
ES96202972T ES2131907T3 (en) | 1989-05-02 | 1990-04-30 | VINYL CARBONATE AND VINYL CARBAMATE MONOMERS FOR A CONTACT LENS MATERIAL. |
ES90304659T ES2104583T3 (en) | 1989-05-02 | 1990-04-30 | MONOMER POLYMERS VINYL CARBONATE AND VINYL CARBAMATE FOR CONTACT LENS MATERIALS. |
DE69032984T DE69032984T2 (en) | 1989-05-02 | 1990-04-30 | Vinyl carbonate and vinyl carbamate monomers as a material for contact lenses |
SG1996007715A SG49218A1 (en) | 1989-05-02 | 1990-04-30 | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
EP90304659A EP0396364B1 (en) | 1989-05-02 | 1990-04-30 | Copolymers of vinyl carbonate and vinyl carbamate as contact lens material |
EP96202972A EP0757033B1 (en) | 1989-05-02 | 1990-04-30 | Vinyl carbonate and vinyl carbamate monomers for a contact lens material |
DE69030898T DE69030898T2 (en) | 1989-05-02 | 1990-04-30 | Copolymers of vinyl carbonate and vinyl carbamate monomers as a material for contact lenses |
KR1019900006178A KR0171402B1 (en) | 1989-05-02 | 1990-05-01 | Novel vinyl carbonated and vinyl carbamate contact lens material monomers |
AU54616/90A AU645749B2 (en) | 1989-05-02 | 1990-05-01 | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
BR909002045A BR9002045A (en) | 1989-05-02 | 1990-05-02 | COPOLIMERO; COPOLIMERO HIDROGEL; COPOLIMERO NON-HYDROGEL; CONTACT LENS MATERIAL FOR GAS AND COMPOUNDS; AND ITS PREPARATION PROCESSES |
US08/450,510 US5610252A (en) | 1989-05-02 | 1995-05-25 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
US08/784,637 US6166236A (en) | 1989-05-02 | 1997-01-21 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
HK98100504A HK1001565A1 (en) | 1989-05-02 | 1998-01-20 | Copolymers of vinyl carbonate and vinyl carbamate as contact lens material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/346,204 US5070215A (en) | 1989-05-02 | 1989-05-02 | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US72409191A Division | 1989-05-02 | 1991-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
US5070215A true US5070215A (en) | 1991-12-03 |
Family
ID=23358395
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/346,204 Expired - Lifetime US5070215A (en) | 1989-05-02 | 1989-05-02 | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
US08/450,510 Expired - Lifetime US5610252A (en) | 1989-05-02 | 1995-05-25 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
US08/784,637 Expired - Fee Related US6166236A (en) | 1989-05-02 | 1997-01-21 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/450,510 Expired - Lifetime US5610252A (en) | 1989-05-02 | 1995-05-25 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
US08/784,637 Expired - Fee Related US6166236A (en) | 1989-05-02 | 1997-01-21 | Vinyl carbonate and vinyl carbamate contact lens material monomers |
Country Status (12)
Country | Link |
---|---|
US (3) | US5070215A (en) |
EP (2) | EP0396364B1 (en) |
JP (1) | JP3274681B2 (en) |
KR (1) | KR0171402B1 (en) |
AU (1) | AU645749B2 (en) |
BR (1) | BR9002045A (en) |
CA (1) | CA2014210C (en) |
DE (2) | DE69032984T2 (en) |
ES (2) | ES2104583T3 (en) |
HK (1) | HK1001565A1 (en) |
IE (1) | IE81155B1 (en) |
SG (1) | SG49218A1 (en) |
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Also Published As
Publication number | Publication date |
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HK1001565A1 (en) | 1998-06-26 |
CA2014210A1 (en) | 1990-11-02 |
EP0396364A2 (en) | 1990-11-07 |
EP0396364B1 (en) | 1997-06-11 |
CA2014210C (en) | 1999-08-31 |
US5610252A (en) | 1997-03-11 |
US6166236A (en) | 2000-12-26 |
AU5461690A (en) | 1990-11-08 |
ES2131907T3 (en) | 1999-08-01 |
KR0171402B1 (en) | 1999-03-30 |
JPH0372506A (en) | 1991-03-27 |
BR9002045A (en) | 1991-08-13 |
DE69032984T2 (en) | 1999-07-08 |
DE69030898D1 (en) | 1997-07-17 |
SG49218A1 (en) | 1998-05-18 |
DE69030898T2 (en) | 1997-12-04 |
ES2104583T3 (en) | 1997-10-16 |
EP0757033B1 (en) | 1999-03-03 |
EP0757033A3 (en) | 1997-03-05 |
IE81155B1 (en) | 2000-05-03 |
IE901384L (en) | 1990-11-02 |
DE69032984D1 (en) | 1999-04-08 |
EP0757033A2 (en) | 1997-02-05 |
KR900018164A (en) | 1990-12-20 |
AU645749B2 (en) | 1994-01-27 |
EP0396364A3 (en) | 1991-11-27 |
JP3274681B2 (en) | 2002-04-15 |
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