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Sterile container for collecting biological samples for purposes of analysis

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Publication number
US4982615A
US4982615A US07339652 US33965289A US4982615A US 4982615 A US4982615 A US 4982615A US 07339652 US07339652 US 07339652 US 33965289 A US33965289 A US 33965289A US 4982615 A US4982615 A US 4982615A
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Prior art keywords
flask
bottom
end
cap
means
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Expired - Fee Related
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US07339652
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Bernard Sultan
Pierre Muraz
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Bernard Sultan
Pierre Muraz
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B10/007Devices for taking samples of body liquids for taking urine samples

Abstract

A device intended to facilitate the taking of excretal biological specimens while eliminating the risk of contamination of the collected biological sample. The collected biological sample may be a urine sample or a stool sample. The device is characterized in that it comprises a flask with an open top end sealingly capped by a first cap, and a closed bottom capped by a second cap, the second cap being intended to seal the open top end after removal of the first cap and after introduction of the biological sample into the flask. An outer collar about the flask excludes contamination from the bottom cap during collection of the sample. The flask has an attachable handle. The handle has a flat tongue provided with a wide, longitudinally extending aperture for preventing drops of the sample from reaching the fingers of a person holding the flask.

Description

BACKGROUND OF THE INVENTION

The object of the present invention is a sterile container which facilitates the collection of an essentially urinary biological sample while considerably restricting contamination of the sample by possible outside germs, referred to as "contamination".

At the present time, the urinary sepcimen for cytobacteriological examination is in 95% of cases taken in the patient's home, the patient actually collecting the specimen of urine in a simple flask provided with a screwed stopper, which is then taken to the laboratory for analysis.

The disadvantages of using such a vessel are manifold:

At the level of the technique of taking the sample, the hand holding the flask will almost always be contaminated by the stream of urine because the sample has to be taken from the middle of the urination.

At the level of the cytobacteriological study, the interpretation of results will very often be falsified by indirect contamination of the urine specimen, of which the isolated or associated causes are essentially:

The sterile inside faces of the stopper but also and above all the exposed edge of the flask opening are brushed or touched by the fingers.

While the bottle is being filled, the cork may be provisionally set down on any non-sterile surface.

Accidental and frequent dropping of the stopper.

Prolonged exposure of its sterile inner faces to the non-sterile free air throughout the period of urination and even longer if the stopper is temporarily mislaid, which is far from being a rare occurrence.

SUMMARY OF THE INVENTION

The object of the present invention is to remedy these disadvantages and sets out to provide a means whereby it is possible to improve the technique of taking the specimen, ensuring the quality of the biological sample to allow better interpretation of the results of the biological analysis.

To this end, the invention relates to a device of the type mentioned hereinabove characterised in that it consists of a flask with an open top end capped by a first closure means having a closed end, capped by a second closure means, the second closure means being intended to cover the open top end after removal of the first closure means and introduction of the biological sample into the container.

Therefore, by reason of this device, the user first removes the means of occluding the opening in order to introduce the specimen and then he closes the opening again, using the second closure means which remains as a kind of reserve at the other end of the device. Thus, the device can be closed by a sterile occluding means, the sterility of the inside surfaces of the occluding means, at the level of the opening, have been ensured by the first closure means.

Therefore, this invention will find an application in medical biology: coproculture but above all cytobacteriological examination of urine, and it is this latter aspect which will be mainly developed here.

According to another characteristic feature, the first closure means is an operculum and/or a cap while the second closure means is a cap.

When the first closure means is an operculum, in other words a lid or cover, this may be protected from the bacteriological and mechanical points of view by a supplementary cap.

According to another characteristic feature, the top end and the bottom end are provided with an identical screwthread and the top and bottom caps are provided with a corresponding screwthread so that one can be screwed on the screwthread at the top end and the other on the screwthread at the bottom end, in a standby position and then on the screwthread at the top end after removal of the first cap and introduction of the biological sample.

Although the cap may be simply fitted onto the flask, it is worthwhile screwing it as in the embodiment in accordance with the characteristic features indicated hereinabove.

In order more satisfactorily to preserve sterility of the inner faces of this supplementary stopper, the wall of the flask comprises over its entire perimeter an outside reinforcing means which projects beyond the bottom screwthread, so constituting a small collar which is itself recessed on its bottom surface with a channel adapted to receive the free edge of the stopper over its entire circumference.

Still with a view to preserving the sterility of this "bottom" stopper, the wall of the flask is extended downwardly and by a few millimetres beyond the circular bottom of the container.

According to another characteristic feature, the flask is cylindrical and has a circular cross-section.

To facilitate gripping, it is a good idea for the flask to be provided with a handle and for this to have a wide opening in its centre.

The handle can be fixed rigidly to the flask or may be removable by means of a hook and aperture fitting.

According to another charactistic feature, the wall of the flask is extended downwardly beyond the bottom and constitutes a free circular edge on a bottom cylindrical closed end member and the bottom of the flask is lined with a bacteriostatic agent.

Thus, by way of example, the flask comprises on its wall, at about two-thirds of its height, a right-angled hook which is open at the bottom so that it can receive a flat handle provided with a transverse slot at its proximal end and on the flat surface, the handle being provided with a wide longitudinally extending aperture to avoid possible drops of urine reaching the fingers of the person holding the flask.

Thus, the advantage of this invention resides in having available a sterile flask:

the opening of which is initially and provisionally hermetically sealed by a sterile occluding means which will no longer be used for re-closing the filled flask, because this would be highly likely to have been contaminated while the specimen was being taken. After the flask has been opened, therefore, this occluding means will be disposable:

the final closure of which after filling will be performed by means of another sterile occluding means which is quickly freed from the bottom part to which it was hitherto attached, and where it will not have been subject to any risk of contamination.

The whole assembly is provided with a handle which makes it possible to keep the hand holding the flask well away from the sterile exposed edges thereof.

Thus, when the urine specimen is being taken, the patient

holds the flask by the end of its handle,

opens it and throws away the stopper which initially closed the flask,

takes the sample of urine,

once the flask is filled, rapidly removes the other sterile stopper from the bottom so that he can immediately and without releasing it use this in order finally to close the flask.

All the risks of contaminating the urine specimen which were listed earlier have thus been avoided.

In order to take samples of stool, the same method will be used with, above all, a wider flask and a strong and longer rigid handle.

BRIEF DESCRIPTION OF THE DRAWINGS

A simple and preferred embodiment of the invention is described hereinafter, reference being made to the accompanying drawings in which:

FIG. 1 shows the device according to the invention in longitudinal section and shows the handle in a perspective view;

FIG. 2 is a sectional view of an alternative form of bottom end of the device according to an alternative embodiment.

DETAILED DESCRIPTION OF THE INVENTION

According to the embodiment shown in FIG. 1, the invention refers to a device intended to facilitate the taking of a urine specimen while eliminating the risks of the biological sample which is thus collected being contaminated. This device consists of a flask 100 having an open top end 101 and a closed bottom 102. The open top end 101 is capped by a first occluding means 103 in the form of a cap, while the bottom end 102 is capped by a second occluding means 104 which is in a protected and standby situation. According to the example shown in FIG. 1, the two caps 103, 104 are provided on the inside with a screwthread, not shown, adapted to co-operate with the screwthread 105 on the top end and the screwthread 106 on the bottom end.

According to an alternative embodiment, the top end is closed by a detachable operculum 107 which may or may not be covered by a cap 103. In this case, this operculum (with or without the cap 103) constitutes the first occluding means.

In FIG. 1, the bottom end is extended beyond the bottom 102 by a circular free edge 120 forming a bottom closure member intended to complete the sealing-tightness and ensure perfect sterility of the stopper.

For use, the first occluding means, that is to say the cap 103 and/or the operculum 107, is removed so that the specimen can be taken and then the cap 104 is used, having been hitherto in a protected situation, in order to close the flask again.

According to the invention, the flask 100 may be of any shape; generally, it will be a cylindrical flask of circular cross-section. This flask may consist of any rigid plastics material which is more or less flexible and which has the capacity of about 40 ml.

According to FIG. 1, the cap 104 fits under an outer reinforcement 108 which constitutes a collar and of which the bottom surface is provided with a recessed groove 109 which receives and protects the top edge 110 of the cap 104.

According to the invention, in the event of the caps 103 and 104 being fixed by being screwed, their screwthreads are the same and the screwthreads 105 and 106 are likewise identical.

To distinguish between the caps or more generally the occluding means 103 and 104, these are of different colours.

According to an alternative embodiment, not shown, the membrane or operculum 107 which closes the top opening 101 of the flask 100 is not covered by a cap; this operculum is simply fixed by being glued or in some other manner to the free edge of the opening 101.

According to another alternative embodiment, not shown, the occluding means or caps 103, 104 are simply engaged by friction on the corresponding end of the flask or are clipped into position.

FIG. 2 shows another alternative method of fixing the bottom cap 104A which comprises a screwthreaded central boss 111 which is screwed into the cavity 112 in the bottom 102 of the flask which is partially illustrated.

According to the invention, the flask 100 is provided with a handle or grip which may be fixed, removable or capable of being folded over. In the embodiment shown in FIG. 1, the handle is adaptable and for this purpose the flask 100 comprises a downwardly curved hook 113 and the adaptable handle 114 comprises a front loop 115 shaped like a segment of a circular cylinder or more generally shaped to match the shape of the wall of the flask 100 and is extended by a tongue 116 provided at the front with a slot 117 adapted to receive the hook 113 and at the rear with a large and elongated aperture or slot 118 extending over the entire length of the handle member 116.

This handle may likewise be capable of being folded over, for example by means of a hinge.

According to other alternative embodiments, not shown, the bottom cap may be fixed by a paper collar or other adhesive means set across the edge of the cap and the collar 107.

According to another alternative embodiment, there is likewise a top collar, not shown, in which fits the bottom edge of the top cap 103, still with a view to ensuring a safeguard against contamination.

Finally, it may be worth while introducing a bacteriostatic agent into the flask to prevent propagation of germs in the event of contamination.

Claims (14)

What is claimed is:
1. A device intended to facilitate the taking of an excretal biological sample while eliminating the risks of contamination of the biological sample which is thus collected, the device being characterized in that it comprises a flask (100) having an open top end (101) sealingly capped by a first closure means (103, 107), a closed bottom end (102) capped by a bottom cap (104), and an outer collar (108) mounted about the flask (100) and incorporating a recessed groove (109) at the bottom side of the collar (108) to cover the edge (110) of the bottom cap (104) so as to exclude contamination from the bottom cap (104) when this latter is capping the bottom end (102) of the flask (100), the bottom cap (104) being intended to fit over the open top end (101) after removal of the first closure means (103, 107) and introduction of the biological sample into the flask (100).
2. A device according to claim 1, characterized in that the first closure means is a top cap (103).
3. A device according to claim 2, characterized in that the top end and bottom end are provided with identical screwthreads (105,106), the top cap (103) and bottom cap (104) being provided with a corresponding screwthread so that the top cap (103) can be screwed onto the screwthread (105) on the top end and the bottom cap (104) can be screwed onto the screwthread (106) at the bottom end, in a standby position, and so that the bottom cap (104) can be screwed onto the screwthread (105) at the top end after removal of the top cap (103) from the top end and introduction of the biological sample into the flask.
4. A device according to claim 2, characterized in that the flask is provided with a handle (116).
5. A device according to claim 4, characterized in that the flask, the caps and the handle are made from a plastic material.
6. A device according to claim 4, characteristic in that the handle (116) is provided in the center with a large aperture (118).
7. A device according to claim 6, characterized in that the flask, the caps and the handle are made from a plastic material.
8. A device according to claim 4, characterized in that the handle (116) can fit on a hook (113) provided on the flask (100), for which purpose it comprises a transverse slot (117) and a loop (115) which can be fitted against the wall of the flask (100).
9. A device according to claim 8, characterized in that the flask, the caps and the handle are made from a plastic material.
10. A device according to claim 4, characterized in that the wall of the flask (100) is extended downwardly beyond the bottom (102) and constitutes a circular free edge (120) around a bottom cylindrical closure member, the bottom of the flask being lined with a bacteriostatic agent.
11. A device according to claim 10, characterized in that the flask, the caps and the handle are made from a plastic material.
12. A device according to claim 1, characterized in that the flask (100) is cylindrical and is of a circular cross-section.
13. A device according to claim 1, characterized in that the first closure means is an operculum (107).
14. A device intended to facilitate the taking of an excretal biological sample while eliminating the risks of contamination of the biological sample which is thus collected, the device being characterized in that it comprises a flask (100) having an open top end (101) sealingly closed by a first closure means (103, 107), a closed bottom end (102) capped by a bottom cap (104), the bottom cap (104) being intended to fit over the top end (101) after removal of the first closure means (103, 107) and introduction of the biological sample into the flask (100), and a handle (116) attachable to the flask, the handle (114) having a flat tongue (116) provided with a wide, longitudinally extending aperture (118) for preventing drops of the biological sample from reaching the fingers of a person holding the flask.
US07339652 1988-04-18 1989-04-18 Sterile container for collecting biological samples for purposes of analysis Expired - Fee Related US4982615A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8805100 1988-04-18
FR8805100A FR2630000A1 (en) 1988-04-18 1988-04-18 Bottle indicated to collect a urine sample for biological examination cytobacteriological

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US4982615A true US4982615A (en) 1991-01-08

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US (1) US4982615A (en)
JP (1) JPH0216450A (en)
DK (1) DK187089D0 (en)
EP (1) EP0338886A1 (en)
FI (1) FI891847A (en)
FR (1) FR2630000A1 (en)

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US5442970A (en) * 1994-06-23 1995-08-22 Hutchins; Charles D. Water sampling device
US5451375A (en) * 1993-01-28 1995-09-19 Chemplex Industries, Inc. Apparatus for trimless sample cup used in X-ray spectroscopy
US5454020A (en) * 1994-07-13 1995-09-26 Chemplex Industries, Inc. Sample cup adapted for upright horizontal and inclined sample plane geometry systems
US5630989A (en) * 1994-08-17 1997-05-20 Chemplex Industries, Inc. Apparatus for trimless sample cup used in X-ray spectroscopy
US5670325A (en) * 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5928870A (en) * 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020137A (en) * 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6146828A (en) * 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
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US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
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US6351857B2 (en) 1999-05-03 2002-03-05 Exact Sciences Corporation Stool specimen collector
US20020064792A1 (en) * 1997-11-13 2002-05-30 Lincoln Stephen E. Database for storage and analysis of full-length sequences
US6406857B1 (en) 1997-06-16 2002-06-18 Exact Sciences Corporation Methods for stool sample preparation
US6475738B2 (en) 1999-01-10 2002-11-05 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6482595B2 (en) 1999-08-11 2002-11-19 Exact Sciences Corporation Methods for detecting mutations using primer extension
US6551777B1 (en) 1999-02-25 2003-04-22 Exact Sciences Corporation Methods for preserving DNA integrity
US20030203382A1 (en) * 2002-02-15 2003-10-30 Exact Sciences Corporation Methods for analysis of molecular events
US20040035607A1 (en) * 2002-06-06 2004-02-26 En Novative Technologies And Kejr, Inc. Soil sample containment device and method
US20040043467A1 (en) * 1999-12-07 2004-03-04 Shuber Anthony P. Supracolonic aerodigestive neoplasm detection
US6796194B1 (en) 2001-10-09 2004-09-28 San Diego State University Liquid sampling device
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US20050126824A1 (en) * 2002-06-06 2005-06-16 En Novative Technologies, Inc. Soil sampling system and method that allow headspace screening at spaced intervals without disturbing soil sample
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US20050185978A1 (en) * 2004-02-20 2005-08-25 Canon Kabushiki Kaisha Image fixing apparatus capable of changing surface condition of fixing rotary member and fixing rotary member for use therein
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US7014231B1 (en) 2005-01-11 2006-03-21 Callen Chris D Pool maintenance device
US20070202513A1 (en) * 1999-09-08 2007-08-30 Exact Sciences Corporation Methods for disease detection
US20080124714A1 (en) * 2004-05-14 2008-05-29 Exact Sciences Corporation Method for Stabilizing Biological Samples for Nucleic Acid Analysis
US9339954B2 (en) 2013-10-11 2016-05-17 Michael C. Solazzi Portable sample pulverizing and pelletizing system and method
US9829446B1 (en) 2012-03-05 2017-11-28 Chemplex Industries, Inc. Sample cup and method for mounting a thin film of material across a sample cup
US9841360B1 (en) 2012-10-15 2017-12-12 Michael C. Solazzi Sample cup assembly, system and method for purging

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US5451375A (en) * 1993-01-28 1995-09-19 Chemplex Industries, Inc. Apparatus for trimless sample cup used in X-ray spectroscopy
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US5454020A (en) * 1994-07-13 1995-09-26 Chemplex Industries, Inc. Sample cup adapted for upright horizontal and inclined sample plane geometry systems
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US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
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US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
US5928870A (en) * 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US20020064792A1 (en) * 1997-11-13 2002-05-30 Lincoln Stephen E. Database for storage and analysis of full-length sequences
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6475738B2 (en) 1999-01-10 2002-11-05 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6498012B2 (en) 1999-01-10 2002-12-24 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6551777B1 (en) 1999-02-25 2003-04-22 Exact Sciences Corporation Methods for preserving DNA integrity
US20100173320A1 (en) * 1999-04-09 2010-07-08 Genzyme Corporation Methods for Detecting Nucleic Acids Indicative of Cancer
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6351857B2 (en) 1999-05-03 2002-03-05 Exact Sciences Corporation Stool specimen collector
US6415455B1 (en) 1999-05-03 2002-07-09 Exact Sciences Corporation Stool specimen collector
US6482595B2 (en) 1999-08-11 2002-11-19 Exact Sciences Corporation Methods for detecting mutations using primer extension
US7811757B2 (en) 1999-09-08 2010-10-12 Genzyme Corporation Methods for disease detection
US20070202513A1 (en) * 1999-09-08 2007-08-30 Exact Sciences Corporation Methods for disease detection
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US20040043467A1 (en) * 1999-12-07 2004-03-04 Shuber Anthony P. Supracolonic aerodigestive neoplasm detection
US7981612B2 (en) 1999-12-07 2011-07-19 Mayo Foundation For Medical Education And Research Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm
US20080254547A1 (en) * 1999-12-07 2008-10-16 Shuber Anthony P Supracolonic aerodigestive neoplasm detection
US20080248471A1 (en) * 1999-12-07 2008-10-09 Shuber Anthony P Methods for disease detection
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US6796194B1 (en) 2001-10-09 2004-09-28 San Diego State University Liquid sampling device
US8409829B2 (en) 2002-02-15 2013-04-02 Esoterix Genetic Laboratories, Llc Methods for analysis of molecular events
US20030203382A1 (en) * 2002-02-15 2003-10-30 Exact Sciences Corporation Methods for analysis of molecular events
US7776524B2 (en) 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US20040035607A1 (en) * 2002-06-06 2004-02-26 En Novative Technologies And Kejr, Inc. Soil sample containment device and method
US7216725B2 (en) * 2002-06-06 2007-05-15 En Novative Technologies, Inc. Soil sampling system and method that allow headspace screening at spaced intervals without disturbing soil sample
US20050126824A1 (en) * 2002-06-06 2005-06-16 En Novative Technologies, Inc. Soil sampling system and method that allow headspace screening at spaced intervals without disturbing soil sample
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Also Published As

Publication number Publication date Type
DK187089D0 (en) 1989-04-18 grant
DK187089A (en) 1989-10-19 application
FI891847A0 (en) 1989-04-18 application
FR2630000A1 (en) 1989-10-20 application
JPH0216450A (en) 1990-01-19 application
FI891847A (en) 1989-10-19 application
EP0338886A1 (en) 1989-10-25 application
FI891847D0 (en) grant

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