US4850960A - Diagonally tapered, bevelled tip introducing catheter and sheath and method for insertion - Google Patents

Diagonally tapered, bevelled tip introducing catheter and sheath and method for insertion Download PDF

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US4850960A
US4850960A US07/071,040 US7104087A US4850960A US 4850960 A US4850960 A US 4850960A US 7104087 A US7104087 A US 7104087A US 4850960 A US4850960 A US 4850960A
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catheter
vessel
bevelled
sheath
introducing
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Joseph Grayzel
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Priority to PCT/US1988/002285 priority patent/WO1989000060A1/fr
Priority to CA000571577A priority patent/CA1305004C/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/06—Body-piercing guide needles or the like
    • A61M25/065—Guide needles

Definitions

  • the present invention relates to introducing catheters and specifically to such a catheter having a bevelled introducing tip, a cylindrical portion between the end of the bevel and a tapered portion. Visible indicia are provided on the introducing catheter, the indicia starting at the tip.
  • the invention also relates to introducing sheaths having a bevelled introducing tip and visible indicia to locate the position of the bevel.
  • a needle punctures the skin and is directed into the blood vessel, such entry generally heralded by the back-flow of blood through said needle.
  • a fine guide wire in the form of a tightly coiled helix is inserted within said needle, enters said blood vessel where it is advanced so that a portion lies securely within the blood vessel for some length while the remainder lies above the skin surface.
  • a so-called introducnng or dilating catheter with tapered tip is threaded over the proximal end of the guide wire and advanced along the guide wire as its tip passes through the skin, subcutaneous tissue, and blood vessel wall to enter the lumen of the blood vessel continually guided by the flexible helical wire.
  • the purpose of this introducing and/or dilating catheter is to expand the vascular puncture hole so that it will accommodate the operational diagnostic or therapeutic catheter to be finally inserted.
  • Introducing catheters presently in use are chosen with an outer diameter identical to that of the operational catheter, but the introducing catheter possesses a tip which tapers down to the outer diameter of the guide wire.
  • the present art for such a tapered tip is exclusively that comprising a taper which is radially symmetrical.
  • the taper involves both the lumen and the wall of the introducing-dilating catheter over a length of approximately 20 mm. Therefore, when passed over the guide wire into the blood vessel, a sufficient portion of he introducing-dilating catheter is inserted into the blood vessel so that the entire tapered tip as well as some portion of the full diameter of the catheter lies within said vessel, thereby insuring that the vascular puncture hole has been dilated to the full diameter of the catheter.
  • a thin-walled outer tubular member, called a sheath is passed over the proximal end of the introducing-dilating catheter, to whose diameter it fits precisely, and then the sheath and catheter are advanced through the skin, subcutaneous tissue and blood vessel wall until its distal portion of the sheath enters the lumen of said blood vessel.
  • the introducing catheter and internal guide wire are quickly removed from the sheath while maintaining the position of the tubular sheath within the blood vessel, and the operational catheter is inserted via the sheath into the blood vessel, from whence it can be manipulated to other locations within the circulatory system.
  • Thompson U.S. Pat. No. 3,921,631 shows a device for insertion of catheters using a hollow slotted needle. This is a so-called "through-the-needle" catheter insertion apparatus.
  • the needle tip 20 is bevelled to form a cutting edge which results in a shearing or slicing action when forming the puncture hole rather than a tearing action, so as to produce a smooth puncture rather than a ragged puncture.
  • a varying diameter tapered section is employed at the distal end of the catheter hub to seal the space between the needle and the catheter to prevent bleeding.
  • Suzuki et al. U.S. Pat. No. 4,629,450 discloses an instrument comprising an inner needle with a tip formed to include a cutting edge, and a dilator portion having a hollow dilator with a tip for enabling the inner needle to be passed therethrough until the cutting edge of the inner needle projects from the tip of the dilator.
  • the cutting tip of the inner needle makes the initial puncture of the vessel.
  • the inner needle is then withdrawn leaving the dilator portion in place.
  • a guide wire is then inserted through the dilator.
  • a secondary thicker portion of the dilator is then inserted along the guide wire to widen the opening.
  • the dilator is then withdrawn and the catheter is inserted over and along the guide wire.
  • the elasticity of the blood vessel permits some movement of the vessel wall at the acute angle such that the entire blunt circumference of the catheter tip is pressing against the entire circumference of the puncture hole as force is applied to effect entry of the catheter.
  • the required force is considerable and the catheter generally pops through the puncture hole suddenly with a palpable abruptness. This may cause additional trauma or tearing at the puncture site.
  • the present invention provides an improved introducing-dilating catheter which may also be applied to facilitate insertion of catheters of all types and functional purposes.
  • the catheter has a tapered portion which is, in turn, connected to a bevelled tip portion to facilitate insertion of the catheter into a pre-existing puncture aperture.
  • the bevelled tip portion is finished to remove any points capable of puncturing or any edges capable of injuring the tissues by the application of only a small force.
  • Indicia means are provided to enable the practitioner using the introduction-dilation catheter to determine the orientation of the tip of the catheter so that the leading point of the bevelled tip will initiate engagement with the vascular puncture cut and enter the vessel in the acute angle formed between the guide wire and the vessel wall. Additionally, after entry of the entire tip, the indicia means allow the introducing catheter to be re-oriented once inserted into the vessel so as to keep the bevel parallel to the wall of a vessel.
  • the present invention also sets forth a sheath with a bevelled introducing tip and visible indicia to indicate the position of the tip, which sheath functions during introduction in much the same manner as the bevelled tip introducing catheter, to achieve the same beneficial results relating to ease of entry and proper positioning.
  • an object of the present invention to provide an introducing catheter and/or sheath having a bevelled tip surface which is formed in either a planar or a concave configuration.
  • Yet another object of the present invention is to provide an introducing catheter and/or sheath having a bevelled tip surface in which the end of the bevel rearmost from the tip is chamfered to provide a smoother surface for introduction into the body.
  • Still another object of the present invention is to provide an introducing catheter which has a cylindrical portion between the tapered portion and the bevelled tip thereof.
  • a further object of the present invention is to provide an introducing catheter which separates the entry function of the catheter from the dilation function of the catheter.
  • Yet a further object of the present invention is to provide an introducing catheter which spaces the entry tip of the catheter from the tapered dilating portion of the catheter.
  • Another object of the present invention is to provide an introducing catheter which is utilized after the catheter guide wire is inserted into the vessel, the initial surfaces contacting the skin being such that minimal force is required to insert the introducing catheter into the vessel.
  • Still another object of the present invention is to provide a catheter and/or sheath having a bevelled tip surface which is formed in the shape of either a plane or in a concave manner, the end of the bevel rearmost from the tip being optionally chamfered to provide still smoother surfaces for introduction into the body.
  • a still further object of the present invention is to provide a bevelled introducing catheter which cooperates with the guide spring residing in the vessel.
  • a still further object of the present invention is to provide a bevelled introducing catheter and/or sheath with an indicator visible along the introducing catheter to provide proper orientation of the bevel relative to the vessel.
  • Another object of the present invention is to provide an insertion catheter and/or sheath which has an indicator constituted by a colored stripe running the entire length of the introducing catheter.
  • a further object of the present invention is to provide an introducing catheter and/or sheath which, if desired, may have a hardened tip portion to facilitate introduction in some applications.
  • Still another object of the present invention is to provide an introducing catheter and/or sheath which reduces the risk of tearing the vessel wall at initial introduction of the tip of the catheter and/or sheath, which introduction by the catheter is done to enlarge the size of the puncture in the wall of the vessel.
  • a further object of the present invention is to provide an introducing catheter and/or sheath which is safer because it reduces the chance of injury to the rear wall of the vessel in which it is inserted, such as with abrasion resulting from contact with the leading edge or tip of the catheter and/or sheath during movement with the vessel, as for example which occurs with the catheter during passage of the tapered dilating portion of the device.
  • Still another object of the present invention is to provide an inserting catheter and/or sheath which minimizes the size of the hole by causing the catheter to be introduced atraumatically, permitting enlargement of the puncture hole by elastic dilatation rather than by tearing.
  • Yet another object of the present invention is to provide an insertion catheter and/or sheath which provides better control during introduction by reducing the axial force necessary to penetrate the muscular wall of the vessel into which it is introduced.
  • a further object of the present invention is to provide a bevelled insertion catheter and/or sheath which is safer because it allows rotation of the bevelled leading point to the optimum position for safety after full insertion of the catheter.
  • Still another object of the present invention is to provide an insertion catheter and/or sheath having indicia to indicate rotational orientation of the tip of the catheter disposed at a plurality of radial locations along the circumference of the catheter.
  • Yet another object of the present invention is to provide an insertion catheter and/or sheath having primary, secondary and tertiary indicia for the location of the bevel at the insertion tip of the catheter and/or sheath.
  • a further object of the present invention is to provide an insertion catheter having a bevelled tip wherein the bevelled tip has a strengthened and/or hardened insertion portion.
  • Another object of the present invention is to provide an insertion catheter having a bevelled tip wherein the bevelled tip has a strengthened and/or hardened insertion portion where the tip is formed from a composite of plastic and another material such as metal or a ceramic.
  • Still another object of the present invention is to provide an insertion catheter having a bevelled tip wherein the tip of the bevelled catheter is strengthened and/or hardened by metallic plating.
  • Yet another object of the present invention is to provide an insertion catheter having a bevelled tip wherein the tip of the catheter is strengthened and/or hardened by irradiating the tip to increase the cross-linking of the polymer used to form the catheter.
  • Another object of the present invention is to provide a bevelled introducing catheter and/or sheath wherein the bevel can be positioned during various stages of the insertion procedure.
  • a further object of the present invention is to provide an insertion dilation catheter having a tapered dilating portion in which the taper is entirely on the outer surface of the dilating portion of the catheter.
  • Still another object of the present invention is to provide an insertion dilation catheter having a tapered outer portion with a fine bore of substantially constant diameter extending at least partially through the tapered outer section; and also having a conical bore segment which communicates the fine inner bore to the larger bore of the catheter.
  • the conical bore segment facilitates the threading of guide wires into the constant diameter bore.
  • Yet another object of the present invention is to provide a method of inserting a bevelled catheter and/or sheath into a blood vessel by a percutaneous procedure in which the catheter can be inserted with the point of the bevel positioned for optimum entry and then rotated to minimize the likelihood of contact injury by the pointed end of the bevel with the back wall of the vessel into which the bevelled end has been inserted.
  • Another object of the present invention is to provide a method of sequentially inserting an introducing catheter and a sheath into a blood vessel by a percutaneous procedure in which the catheter can be inserted with the point of the bevel positioned for optimum entry and then rotated to minimize the likelihood of contact injury by the pointed end of the bevel to the back wall of the vessel.
  • the sheath can be inserted by sliding it over the catheter if the sheath is not already on the body of the catheter. Then the catheter and sheath advance as a unit with the point of the sheath bevel positioned for optimum entry and then rotated to minimize the likelihood of contact injury by the pointed end of the bevel to the back wall of the vessel into which the bevel end has been inserted.
  • the introducing catheter and guide wire are removed, leaving the sheath in place.
  • FIG. 1 is a side view in section of the introducing catheter of the present invention
  • FIG. 2 is a top view of the introducing catheter of the invention
  • FIG. 3 is a view showing in section the catheter in use with a spring-guide in a blood vessel
  • FIGS. 4A-4D are side views in section showing different configurations of bevels employed in the catheter
  • FIG. 5 is another embodiment of the invention similar to that shown in FIG. 1;
  • FIG. 6 is another embodiment of the invention similar to that shown in FIG. 2;
  • FIG. 7 is a view similar to FIG. 3 showing the initial entry stage of the catheter into the blood vessel
  • FIG. 8 is a view similar to FIG. 7 showing an intermediate entry stage of the catheter int the blood vessel
  • FIG. 9 is a view similar to FIG. 7 showing the catheter repositioned to minimize the angle between the bevel and the wall of the vessel to rotate the tip away from the wall;
  • FIG. 10 is a top view of a sheath with a bevelled tip and indicia
  • FIG. 11 is a side view in section of the sheath shown in FIG. 10;
  • FIG. 12 is a view similar to FIG. 7 showing the sheath positioned on an introducing dilating catheter which has been placed in the lumen of the vessel, with the sheath about to make its initial entry into the blood vessel;
  • FIG. 13 is a view similar to FIG. 8 showing an intermediate entry stage of the sheath into the blood vessel;
  • FIG. 14 is a view showing the sheath finally positioned within the lumen of the blood vessel and the introducing dilating catheter and guide wire withdrawn.
  • the improved introducingdilating catheter of the invention overcomes the disadvantages described above by possessing a bevelled tip 1, and a longitudinal stripe 2 in line with the rearmost point 3 of the bevelled end, hence 180° away from the leading point of the bevel, i.e. along the opposite side from the leading point 4 of the bevel.
  • a distal 20 mm portion 5 of the catheter 6 is tapered with respect to both its inner lumen 7 with a constant wall thickness 8, similar to such tapers presently existing on introducing-dilating catheters.
  • the taper 5 is complete at a point several millimeters behind the tip, having attained an internal diameter 10 which matches the outer diameter 11 of the spring-guide 12 (FIG. 3).
  • the last several millimeters at the tip is a truly cylindrical section 9, and it is in this portion that the diagonal bevel cut is made.
  • the bevel 15 should be cut at an angle as acute as possible, preferably 30° or less.
  • the structure disclosed above is advantageous when inserted during a percutaneous insertion procedure (described above) by the following method.
  • the guide wire 12 alone remains in position through the skin, subcutaneous tissue, and blood vessel wall 13, with some length 14 lying within the lumen of said blood vessel.
  • the patient is lying supine, thus placing blood vessels in the upper and lower extremities in the horizontal plane.
  • the original needle puncture is made at an acute angle to the horizontal, generally in the range of 30° to 45°, and thus the guide wire 12 is disposed at this same angle.
  • an introducing-dilating catheter is passed over the guide wire to engage the vessel wall.
  • the introducingdilating catheter 6 is passed over the guide wire 12 with the longitudinal stripe 2 uppermost, clearly visible to the eye, and hence the leading point 4 of the bevel at the catheter's tip 1 is undermost, where it will engage the puncture hole in the vessel wall at the vertex of the acute angle between said vessel wall 13 and the guide wire 12.
  • a minimum area of the catheter tip 1 engages the puncture hole at an acute angle along the underside of the guide wire 12. Therefore, it provides for a minimum force of entry.
  • the remainder of the bevel tip 1 follows by gradual elastic enlargement of the puncture hole until the entire circumference of the tapered tip 1 is within the vascular lumen. Not only is the entry force minimized by the bevel tip 1, but the entry progresses gradually and easily, rather than suddenly with an impulsive discontinuous entry of the tip as now occurs with present art and methodology.
  • bevelled tip may also be applied to construction of the so-called sheath, the thin-walled outer tubular member surrounding the introducing-dilating catheter, which slides over said catheter through the puncture hole, as described in step five above, to provide a final access channel to the blood vessel for insertion of the operational diagnostic or therapeutic catheter.
  • the bevel disclosed herein is designed to effect a gradual spreading force on an existing puncture hole.
  • the application of a bevel configuration employed for non-traumatic insertion into the vascular system is new art for such procedures. Its novelty is further attested by the fact that percutaneous insertion of catheters over guide wires has been practised for nearly 30 years since the technique was first described by Seldinger, yet the use of a bevelled introducing catheter tip to facilitate entry into the blood vessel has not been described or employed.
  • a firm tip may also be provided by a metallic plating of the plastic, as by electroplating.
  • a firm tip may also be provided by applying a coating of an agent which hardens upon curing, i.e. physico-chemical process.
  • a firm tip may also be attained by fabricating the rim of the bevel together with a small portion of the tip, of metal, ceramic, epoxy or other hard material and thn insert-molding of this tip into the thermoplastic body of the catheter.
  • FIGS. 4A-4D Four types of configurations of the bevel are shown in FIGS, 4A-4D.
  • FIG. 4A a planar bevel 16 is shown where the circumferential boundary of the bevel lies in a plane and the bevel, seen in profile, is a straight line.
  • FIG. 4B shows a planar bevel 17 with a chamfer 18.
  • This bevel 17 is similar to the simple planar bevel 16, with the additional feature comprising a rounding of the rearmost portion 18, thereby removing the corner angle created by a planar cut through the wall of the catheter's tip at the rearmost region of the bevel.
  • FIG. 4C employs a concave bevel 19.
  • the bevel 19 is slightly cup-shaped with the edges of the cup, hence the concavity 20 facing forward, thereby accentuating the bevel's acute angle at its leading edge 21, further minimizing the forces of initial entry and proression of the bevel through the puncture hole.
  • FIG. 4D uses a concave bevel 22 with a chamfer 23.
  • This bevel 22 combines the concave profile described in FIG. 4C, with the chamfer described in FIG. 4B.
  • the modification of the bevel by the chamfer 18 or 23 at the rearmost region reduces the local profile of the bevel where it must pass beneath the upper lip of the arterial puncture hole and tereby eliminates the trauma associated with the transition from the bevel to the cylindrical portion 9 of the catheter.
  • FIG. 5 shows another embodiment of the invention with modified construction.
  • the catheter generally indicated at 106 has a thick-walled section 108 immediately behind the cylindrical portion 109 on which the bevelled tip 101 is formed.
  • the external taper 105 occurs in the thick-walled section or at least a part of the thick-walled section of the catheter.
  • the thick-walled section begins at the juncture of the externally tapered section 105 with the cylindrical section 109 and ends at the conical transition 126 of the lumen from the wide portion of the lumen 107 to the narrow portion of the lumen 110 that extends to the tip 101 of the catheter.
  • the walls 128 of the catheter about the larger lumen section 107 are relatively thin and may be in the same nature as the wall thickness of the catheter shown in FIG. 1. Most or all the external tapering from the main body of the catheter to the cylindrical tip section 109 occurs in the thick-walled section 108 of the catheter. The relative position of the internal conical section 126 with respect to the tapered external portion 105 determines the extent of the thickened wall portion 108 of the catheter.
  • the internally tapered section 126 facilitates the threading of a guide wire into the narrow lumen portion 110.
  • the guide wire may merely be inserted in the rear of the catheter toward the front of the conical section 126 of the lumen which will guide the wire to the narrow portion 110 of the lumen that extends to the tip.
  • the advantages of this thick-walled construction are that the catheter can be relatively sturdy and provide a relatively confined channel for the guide wire. The catheter will be able to take a greater axial force from the person controlling the catheter during the introductory procedure. Additionally, if the thick-walled portion extends almost the length of the catheter, then threading of the guide wire into the narrow portion 110 of the lumen is further facilitated.
  • other elements of the device include the walls of the bevel 115 with the forwardmost edge of the bevel 104 and rearmost edge 103.
  • the outer constant diameter of the catheter is indicated as 106 with the wall between the enlarged lumen 107 and the outer diameter being indicated as 128.
  • FIG. 6 shows another embodiment of the invention, similar to that shown in FIG. 2, but in which there are indicating means 202 in the form of a longitudinal stripe as in FIG. 2 but, in addition, indicating means disposed at approximately 90° angles at either side of the central indicating means. These are shown as a series of circles 232 and a series of squares 234.
  • the physician-surgeon using the introducing catheter will always be aware of the position of the plane of the bevel and therefore where the tip of the bevel 204 is with relation to the vascular puncture hole.
  • two indicia disposed 180° apart could also be used rather than four indicia disposed at 90°.
  • the indicating means as shown in FIGS. 2 and 6 enable the introducing catheter to be manipulated to great advantage by the operator surgeon as shown in FIGS. 3, 7, 8 and 9.
  • the bevelled edge of the introducing catheter is near the needle puncture and is moving for insertion along spring-guide 12.
  • the leading edge 4 of the bevel is closest to the puncture hole to facilitate entry via the acute angle between the spring guide and vessel wall 13 as previously described.
  • the catheter moves along the wire until the leading edge 4 has passed through the puncture of the blood vessel.
  • the leading edge 4 of the catheter In the initial entry position, the leading edge 4 of the catheter is in the lowermost position and below the spring-guide 14, and is the first point of the catheter to approach the puncture hole in the vessel.
  • the catheter moves further along the wire as indicated by the arrow until the bevel from leading edge 4 to rear portion 3 is within the blood vessel.
  • the narrow leading edge 4 is near the rear wall of the vessel and could easily come in contact with and/or damage the rear wall.
  • the entire catheter is rotated 180°. Once the rotation occurs, as shown in FIG. 9, the plane of the bevel from leading edge 4 to end 3 will be repositioned to be parallel to the wall of the blood vessel. The leading edge 4 is rotated away from the wall of the vessel. Therefore it will be almost impossible for the leading edge 4 of tip 1 of the catheter to contact the wall of the vessel because the portion 14 of the springguide 12 that is within the vessel will be between the plane of the bevel and the wall of the vessel.
  • FIGS. 10 and 11 show a sheath generally indicated at 306 having a bevelled tip 301 with an entry leading edge 304 and the rearmost portion of the bevelled tip 303.
  • the wall of include the walls of the tapered bevel 115 with the forwardmost the sheath 308 is of a suitable material and it is of constant diameter enclosing a constant diameter lumen 307.
  • the sheath is provided with visible indicia 302, 332 and 334 positioned at 90° intervals about the circumference of the catheter to indicate where the leading edge of the bevel 304 is positioned.
  • the sheath is positioned in coaction with the introducing dilating catheter
  • the introducing dilating cather generally indicated at 506 has been positioned sufficiently far within the lumen of the vessel so that the distal end of the catheter is generally parallel to the walls of the vessel.
  • a sheath 406 is mounted on the tubular portion of the introducing dilating catheter 506 so that the wall of the sheath 408 is in contact with the tubular wall of the catheter 506.
  • the sheath 406 is positioned well back from the insertion or distal end of the catheter.
  • the sheath 406 and catheter 506 are moved together until the forwardmost portion of the bevelled tip 404 of the sheath and the rearmost portion 403 of the sheath have entered into the lumen of the blood vessel.
  • the sheath is then rotated in the same manner as was the introducing catheter so that the bevelled leading edge 404 of the sheath 406 is rotated away from close contact with the rear wall of the blood vessel to reduce the chance of injury to the vessel While sheath 406 is rotated, the leading edge 504 of the catheter 506 is fixed in place by holding the portion of the catheter extending beyond the proximal end 436 of sheath 406.
  • the introducing dilating catheter 506 and the guide wire 514 can be removed leaving the sheath in place to allow for entry of the various devices that will then be placed into the blood vessel.

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US07/071,040 1987-07-08 1987-07-08 Diagonally tapered, bevelled tip introducing catheter and sheath and method for insertion Expired - Lifetime US4850960A (en)

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Application Number Priority Date Filing Date Title
US07/071,040 US4850960A (en) 1987-07-08 1987-07-08 Diagonally tapered, bevelled tip introducing catheter and sheath and method for insertion
PCT/US1988/002285 WO1989000060A1 (fr) 1987-07-08 1988-07-07 Catheter et gaine d'introduction a pointe biseautee
CA000571577A CA1305004C (fr) 1987-07-08 1988-07-08 Catheter a bout biseaute, effile a la diagonale, et sa gaine, et methode d'insertion dudit catheter

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Cited By (151)

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US5057083A (en) * 1989-07-25 1991-10-15 C. R. Bard, Inc. Vascular dilator with truncated tip
US5120299A (en) * 1987-05-22 1992-06-09 Kontron Instruments, Inc. Intra-aortic balloon assembly with hemostasis device
US5139486A (en) * 1991-01-02 1992-08-18 Gerald Moss Dilator/introducer for percutaneous gastrostomy
US5158543A (en) * 1990-10-30 1992-10-27 Lazarus Harrison M Laparoscopic surgical system and method
US5167645A (en) * 1991-07-24 1992-12-01 Castillo R Robert Cholangiography catheter inserter
US5295969A (en) * 1992-04-27 1994-03-22 Cathco, Inc. Vascular access device with air-tight blood containment capability
US5306259A (en) * 1992-08-10 1994-04-26 Cathco, Inc. Vascular access needle having an extended length body
WO1994024948A1 (fr) * 1992-04-23 1994-11-10 Scimed Life Systems, Inc. Dispositif et procede d'obturation de perforations vasculaires
US5403278A (en) * 1992-04-15 1995-04-04 Datascope Investment Corp. Device and method for treating hematomas and false aneurysms
US5443497A (en) * 1993-11-22 1995-08-22 The Johns Hopkins University Percutaneous prosthetic by-pass graft and method of use
US5478352A (en) * 1990-10-01 1995-12-26 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5507744A (en) * 1992-04-23 1996-04-16 Scimed Life Systems, Inc. Apparatus and method for sealing vascular punctures
US5540715A (en) * 1992-07-16 1996-07-30 Sherwood Medical Company Device for sealing hemostatic incisions
US5558652A (en) * 1994-10-06 1996-09-24 B. Braun Medical, Inc. Introducer with radiopaque marked tip and method of manufacture therefor
US5649959A (en) * 1995-02-10 1997-07-22 Sherwood Medical Company Assembly for sealing a puncture in a vessel
US5669931A (en) * 1995-03-30 1997-09-23 Target Therapeutics, Inc. Liquid coils with secondary shape
US5690666A (en) * 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
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