US4430072A - Centrifuge assembly - Google Patents
Centrifuge assembly Download PDFInfo
- Publication number
- US4430072A US4430072A US05/803,007 US80300777A US4430072A US 4430072 A US4430072 A US 4430072A US 80300777 A US80300777 A US 80300777A US 4430072 A US4430072 A US 4430072A
- Authority
- US
- United States
- Prior art keywords
- container
- channel
- bowl
- fluid connections
- rotor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
- B04B2005/045—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation having annular separation channels
Definitions
- centrifuges for separating the components of blood are known in which the centrifuge bowl is reusable, and is provided with relatively complex channeling or grooves, and fluid connections, making the device expensive and difficult to clean and sterilize for each use.
- the present invention provides an improved centrifuge bowl and container assembly for use with blood cell separators of the type shown, for example, in U.S. Pat. No. 3,489,145.
- a solid centrifuge element was used, having appropriate channels cast or machined therein, and did not contemplate reusable bags. Bag structures not requiring channeled support elements are disclosed in U.S. Pat. Nos. 3,748,101 and 4,007,871. However, such arrangements are not as efficient or economically manufactured as the subject invention. None of this art or other known prior art provides a centrifuge assembly comprising a solid reusable rigid center element arranged to provide a conformed channel for a disposable tube of semirigid material, having fluid connections to appropriate ends thereof.
- Another object of the invention is to provide an improved rotor assembly utilizing a disposable container for centrifuging blood to obtain different fractions therefrom.
- a further object of the invention is to provide an improved rotor assembly and associated container for centrifuging blood, which is simple and economical in construction, and the container is disposable after a single use.
- the improved assembly comprises a rotor assembly, which in a first embodiment, constitutes a centrifuge bowl and a filler or center piece, which can be removable from the bowl.
- the center piece and bowl are dimensioned so that an annular channel is formed by the space between the outer circumference of the filler piece and the inner surface of the bowl.
- a ring-like fluid container comprising a tube having a rectangular or substantially rectangular cross section, closed at both ends, and provided with a plurality of fluid connections or inlet and outlet tubes.
- These tubes together with a suitable rotating seal, permit the introduction of whole blood into the container and the withdrawal of blood fractions following centrifugal separation.
- the fluid container and the tubing connections may be formed of medical grade polyvinyl chloride.
- the entire rotor assembly is made in one piece by molding and/or machining, with an appropriate circular channel formed in the rotor.
- FIG. 1 is a diagrammatic perspective view showing a centrifuge bowl, a filler or center piece, and a fluid container in an exploded relation in accordance with one preferred form of the invention
- FIG. 2 is a diagrammatic plan view of the assembly shown in FIG. 1;
- FIG. 3 is a sectional elevational view of the assembly of FIG. 2 taken at the section 3--3;
- FIG. 4 is a diagrammatic cross section elevation view of a centrifuge assembly using a one-piece rotor, in accordance with another preferred embodiment of the invention.
- FIG. 1 a centrifuge bowl 1, arranged to be spun around an axis of rotation by suitable means, not shown since the specific rotating means is not germane to this invention.
- the bowl can be formed of any suitable material such as metal or plastic or a combination of materials.
- a filler or center piece 3 Seated within the bowl 1 is a filler or center piece 3 which can be formed of any suitable material, by molding and/or machining.
- the filler piece 3 is dimensioned so that when in place in the bowl 1, the filler will be concentric with the bowl. It can be retained in place on a central hub, or a plurality of distributed bosses or pins.
- the dimensions of the filler piece are selected so that when the filler piece is in place in the bowl, a circular channel 5 the depth of the bowl will exist between the outer circumference of the filler piece and the inner circumference of the bowl.
- the filler piece 3 has a central hole or opening 7 which accommodates the fluid connections to the fluid container, to be subsequently described, and a rotating seal 9.
- the opening may be dimensioned to fit over a central hub in the bowl, to accurately locate and retain the filler piece.
- the seal may be of the type shown in U.S. Pat. No. 3,489,145, for example.
- Filler piece 3 also has a plurality of radial slots 11 in the upper portion of the piece, which receive the fluid connections or tubes to the container. Additional openings 12 are provided to not only provide dynamic balance of piece 3, but also to serve as finger grips for lifting piece 3 into and out of the bowl 1.
- the fluid container comprises a length of semi-rigid plastic tubing 13, preferably of medical grade polyvinyl chloride, and having a substantially rectangular cross section.
- the tubing is formed in a circular or ring-like shape as shown, and the ends joined together, as by a connector piece 15 to which the ends of the tubing are cemented.
- the connector includes a barrier or wall 16, to isolate one end of the chamber from the other end.
- Fluid connections to the container are provided by a plurality of tubing connections 17 and 19, one of which (17) serves as an input connection, and the remainder (19) serve as output connections between the container 13 and the rotating seal 9.
- FIG. 2 is a plan view of the assembly shown in FIG. 1, and further shows the relationship between the various ports. The relationships are manifest from this figure.
- FIG. 3 is a cross-sectional elevation view taken along the section line 3--3 in FIG. 2. The manner in which the container 13 rests in the channel formed between the filler piece 3 and the centrifuge bowl wall 1 is clearly seen.
- the present invention provides a novel centrifuge assembly which is advantageous from the standpoint of being economical to fabricate and includes a low cost simple disposable fluid container to be discarded after a single use, thereby removing the expensive duties of cleaning and sterilizing required with reusable centrifuge containers.
Landscapes
- Centrifugal Separators (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/803,007 US4430072A (en) | 1977-06-03 | 1977-06-03 | Centrifuge assembly |
CA000300458A CA1206937A (en) | 1977-06-03 | 1978-04-04 | Centrifuge assembly |
GB13661/78A GB1563778A (en) | 1977-06-03 | 1978-04-07 | Centrifuge assembly |
ZA00782114A ZA782114B (en) | 1977-06-03 | 1978-04-12 | Centrifuge assembly |
FR7813284A FR2392725A1 (fr) | 1977-06-03 | 1978-04-27 | Ensemble formant rotor de centrifugeuse et reservoir de fluide pour utilisation dans un tel ensemble |
ES469709A ES469709A1 (es) | 1977-06-03 | 1978-05-11 | Un conjunto de centrifuga perfeccionado |
DE2821056A DE2821056C2 (de) | 1977-06-03 | 1978-05-13 | Flüssigkeitszentrifuge, insbesondere Blutzentrifuge |
CH563678A CH634236A5 (de) | 1977-06-03 | 1978-05-24 | Zentrifugenrotor. |
JP53061799A JPS5844419B2 (ja) | 1977-06-03 | 1978-05-25 | 遠心分離機アツセンブリ− |
IT23825/78A IT1109801B (it) | 1977-06-03 | 1978-05-26 | Apparecchio centrifugatore |
JP56062680A JPS5748349A (en) | 1977-06-03 | 1981-04-27 | Assembly of centrifugal separator |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/803,007 US4430072A (en) | 1977-06-03 | 1977-06-03 | Centrifuge assembly |
Publications (1)
Publication Number | Publication Date |
---|---|
US4430072A true US4430072A (en) | 1984-02-07 |
Family
ID=25185318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US05/803,007 Expired - Lifetime US4430072A (en) | 1977-06-03 | 1977-06-03 | Centrifuge assembly |
Country Status (10)
Cited By (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647279A (en) * | 1985-10-18 | 1987-03-03 | Cobe Laboratories, Inc. | Centrifugal separator |
US4708712A (en) * | 1986-03-28 | 1987-11-24 | Cobe Laboratories, Inc. | Continuous-loop centrifugal separator |
US4790807A (en) * | 1986-09-24 | 1988-12-13 | Fresenius Ag | Centrifuge arrangement |
US4806252A (en) * | 1987-01-30 | 1989-02-21 | Baxter International Inc. | Plasma collection set and method |
US4834890A (en) * | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
US4936820A (en) * | 1988-10-07 | 1990-06-26 | Baxter International Inc. | High volume centrifugal fluid processing system and method for cultured cell suspensions and the like |
US4940543A (en) * | 1987-01-30 | 1990-07-10 | Baxter International Inc. | Plasma collection set |
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5076911A (en) * | 1987-01-30 | 1991-12-31 | Baxter International Inc. | Centrifugation chamber having an interface detection surface |
US5078671A (en) * | 1988-10-07 | 1992-01-07 | Baxter International Inc. | Centrifugal fluid processing system and method |
US5104526A (en) * | 1987-01-30 | 1992-04-14 | Baxter International Inc. | Centrifugation system having an interface detection system |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5316667A (en) * | 1989-05-26 | 1994-05-31 | Baxter International Inc. | Time based interface detection systems for blood processing apparatus |
US5360542A (en) * | 1991-12-23 | 1994-11-01 | Baxter International Inc. | Centrifuge with separable bowl and spool elements providing access to the separation chamber |
US5362291A (en) * | 1991-12-23 | 1994-11-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
US5370802A (en) * | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US5427695A (en) * | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
US5549834A (en) * | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5628915A (en) * | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
US5632893A (en) * | 1987-01-30 | 1997-05-27 | Baxter Internatinoal Inc. | Enhanced yield blood processing systems with angled interface control surface |
US5641414A (en) * | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US5656163A (en) * | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
US5690835A (en) * | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US5704889A (en) * | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus |
US5704888A (en) * | 1995-04-14 | 1998-01-06 | Cobe Laboratories, Inc. | Intermittent collection of mononuclear cells in a centrifuge apparatus |
US5728060A (en) * | 1995-06-07 | 1998-03-17 | Transfusion Technologies Corporation | Blood collection and separation system |
US5733253A (en) * | 1994-10-13 | 1998-03-31 | Transfusion Technologies Corporation | Fluid separation system |
US5792372A (en) * | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US5858251A (en) * | 1996-02-28 | 1999-01-12 | Marshfield Medical Research And Education Foundation, A Division Of Marshfield Clinic | Concentration of waterborne pathogenic organisms |
US5961842A (en) * | 1995-06-07 | 1999-10-05 | Baxter International Inc. | Systems and methods for collecting mononuclear cells employing control of packed red blood cell hematocrit |
US5961846A (en) * | 1996-02-28 | 1999-10-05 | Marshfield Medical Research And Education Foundation | Concentration of waterborn and foodborn microorganisms |
US5980760A (en) * | 1997-07-01 | 1999-11-09 | Baxter International Inc. | System and methods for harvesting mononuclear cells by recirculation of packed red blood cells |
US6007725A (en) * | 1991-12-23 | 1999-12-28 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US6027657A (en) * | 1997-07-01 | 2000-02-22 | Baxter International Inc. | Systems and methods for collecting diluted mononuclear cells |
US6277060B1 (en) * | 1998-09-12 | 2001-08-21 | Fresenius Ag | Centrifuge chamber for a cell separator having a spiral separation chamber |
US6296602B1 (en) | 1999-03-17 | 2001-10-02 | Transfusion Technologies Corporation | Method for collecting platelets and other blood components from whole blood |
US6334842B1 (en) | 1999-03-16 | 2002-01-01 | Gambro, Inc. | Centrifugal separation apparatus and method for separating fluid components |
US6500107B2 (en) | 2001-06-05 | 2002-12-31 | Baxter International, Inc. | Method for the concentration of fluid-borne pathogens |
US6582349B1 (en) | 1997-07-01 | 2003-06-24 | Baxter International Inc. | Blood processing system |
US20030173274A1 (en) * | 2002-02-01 | 2003-09-18 | Frank Corbin | Blood component separation device, system, and method including filtration |
US6632191B1 (en) | 1994-10-13 | 2003-10-14 | Haemonetics Corporation | System and method for separating blood components |
US6736768B2 (en) | 2000-11-02 | 2004-05-18 | Gambro Inc | Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach |
US20040147865A1 (en) * | 1994-10-13 | 2004-07-29 | Cianci James P. | System and method for processing blood |
US6780333B1 (en) | 1987-01-30 | 2004-08-24 | Baxter International Inc. | Centrifugation pheresis method |
US7001321B1 (en) | 1998-03-30 | 2006-02-21 | Baxter International Inc. | Carrier for holding a flexible fluid processing container |
US20070118063A1 (en) * | 2005-10-05 | 2007-05-24 | Gambro, Inc | Method and Apparatus for Leukoreduction of Red Blood Cells |
US7279107B2 (en) | 2002-04-16 | 2007-10-09 | Gambro, Inc. | Blood component processing system, apparatus, and method |
US20090259163A1 (en) * | 2008-04-14 | 2009-10-15 | Etienne Pages | Three-Line Apheresis System and Method |
US20090259162A1 (en) * | 2008-04-14 | 2009-10-15 | Toshiyasu Ohashi | System and Method for Plasma Reduced Platelet Collection |
US20090259164A1 (en) * | 2008-04-14 | 2009-10-15 | Etienne Pages | System and Method for Optimized Apheresis Draw and Return |
US20100234788A1 (en) * | 2009-03-12 | 2010-09-16 | Haemonetics Corporation | System and Method for the Re-Anticoagulation of Platelet Rich Plasma |
US8808978B2 (en) | 2010-11-05 | 2014-08-19 | Haemonetics Corporation | System and method for automated platelet wash |
US9248446B2 (en) | 2013-02-18 | 2016-02-02 | Terumo Bct, Inc. | System for blood separation with a separation chamber having an internal gravity valve |
US9302042B2 (en) | 2010-12-30 | 2016-04-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
US9668523B2 (en) | 2012-01-31 | 2017-06-06 | Altria Client Services Llc | Electronic cigarette |
US10758652B2 (en) | 2017-05-30 | 2020-09-01 | Haemonetics Corporation | System and method for collecting plasma |
US10792416B2 (en) | 2017-05-30 | 2020-10-06 | Haemonetics Corporation | System and method for collecting plasma |
US10946131B2 (en) | 2018-05-21 | 2021-03-16 | Fenwal, Inc. | Systems and methods for optimization of plasma collection volumes |
US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
US11837357B2 (en) | 2011-05-18 | 2023-12-05 | Fenwal, Inc. | Plasma collection with remote programming |
US12033750B2 (en) | 2018-05-21 | 2024-07-09 | Fenwal, Inc. | Plasma collection |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5572860A (en) * | 1978-11-24 | 1980-06-02 | Us Government | Hemocyte separator |
US4283276A (en) * | 1980-02-29 | 1981-08-11 | E. I. Du Pont De Nemours And Company | Rotor for sedimentation field flow fractionation |
US4284497A (en) * | 1980-02-29 | 1981-08-18 | E. I. Du Pont De Nemours And Company | Rotor for sedimentation field flow fractionation |
US4284498A (en) * | 1980-02-29 | 1981-08-18 | E. I. Du Pont De Nemours And Company | Apparatus for field flow fractionation |
US4285809A (en) * | 1980-02-29 | 1981-08-25 | E. I. Du Pont De Nemours And Company | Rotor for sedimentation field flow fractionation |
US4447221A (en) * | 1982-06-15 | 1984-05-08 | International Business Machines Corporation | Continuous flow centrifuge assembly |
AU1968083A (en) * | 1982-09-29 | 1984-04-05 | E.I. Du Pont De Nemours And Company | Replaceable field flow fractionation channel on centrifuge |
JPS63102879A (ja) * | 1986-10-17 | 1988-05-07 | 株式会社 東日製作所 | 動力式ナツトランナ |
US4939087A (en) * | 1987-05-12 | 1990-07-03 | Washington State University Research Foundation, Inc. | Method for continuous centrifugal bioprocessing |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1070407B (de) * | 1956-10-19 | 1959-12-03 | Örebro Karl Erik Harry Danielsson und Johan Folke Sigurd Lundmark (Schweden) | Zentrifuge |
UST955355I4 (US06534493-20030318-C00166.png) * | 1959-06-24 | 1900-01-01 | ||
US3347454A (en) * | 1964-05-13 | 1967-10-17 | Baxter Laboratories Inc | Method and apparatus for the centrifugal washing of particles in a closed system |
BE754683A (fr) * | 1969-08-11 | 1971-01-18 | Aga Ab | Recipient destine a contenir du sang |
DE2104372A1 (de) * | 1970-02-02 | 1971-08-19 | Kerby C | Zentrifuge |
FR2178852B1 (US06534493-20030318-C00166.png) * | 1972-04-07 | 1976-08-27 | Bosch Gmbh Robert | |
US3864089A (en) * | 1973-12-10 | 1975-02-04 | Atomic Energy Commission | Multiple-sample rotor assembly for blood fraction preparation |
FR2273568A1 (fr) * | 1974-06-05 | 1976-01-02 | Commissariat Energie Atomique | Appareil permettant d'effectuer l'echange liquide-liquide par centrifugation |
US3982691A (en) * | 1974-10-09 | 1976-09-28 | Schlutz Charles A | Centrifuge separation and washing device and method |
US4007871A (en) * | 1975-11-13 | 1977-02-15 | International Business Machines Corporation | Centrifuge fluid container |
-
1977
- 1977-06-03 US US05/803,007 patent/US4430072A/en not_active Expired - Lifetime
-
1978
- 1978-04-04 CA CA000300458A patent/CA1206937A/en not_active Expired
- 1978-04-07 GB GB13661/78A patent/GB1563778A/en not_active Expired
- 1978-04-12 ZA ZA00782114A patent/ZA782114B/xx unknown
- 1978-04-27 FR FR7813284A patent/FR2392725A1/fr active Granted
- 1978-05-11 ES ES469709A patent/ES469709A1/es not_active Expired
- 1978-05-13 DE DE2821056A patent/DE2821056C2/de not_active Expired
- 1978-05-24 CH CH563678A patent/CH634236A5/de not_active IP Right Cessation
- 1978-05-25 JP JP53061799A patent/JPS5844419B2/ja not_active Expired
- 1978-05-26 IT IT23825/78A patent/IT1109801B/it active
-
1981
- 1981-04-27 JP JP56062680A patent/JPS5748349A/ja active Pending
Cited By (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US4647279A (en) * | 1985-10-18 | 1987-03-03 | Cobe Laboratories, Inc. | Centrifugal separator |
US4708712A (en) * | 1986-03-28 | 1987-11-24 | Cobe Laboratories, Inc. | Continuous-loop centrifugal separator |
US4790807A (en) * | 1986-09-24 | 1988-12-13 | Fresenius Ag | Centrifuge arrangement |
US4806252A (en) * | 1987-01-30 | 1989-02-21 | Baxter International Inc. | Plasma collection set and method |
US5750039A (en) * | 1987-01-30 | 1998-05-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5632893A (en) * | 1987-01-30 | 1997-05-27 | Baxter Internatinoal Inc. | Enhanced yield blood processing systems with angled interface control surface |
US5104526A (en) * | 1987-01-30 | 1992-04-14 | Baxter International Inc. | Centrifugation system having an interface detection system |
US5628915A (en) * | 1987-01-30 | 1997-05-13 | Baxter International Inc. | Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions |
US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5316666A (en) * | 1987-01-30 | 1994-05-31 | Baxter International Inc. | Blood processing systems with improved data transfer between stationary and rotating elements |
US6228017B1 (en) | 1987-01-30 | 2001-05-08 | Baxter International Inc. | Compact enhanced yield blood processing systems |
US5849203A (en) * | 1987-01-30 | 1998-12-15 | Baxter International Inc. | Methods of accumulating separated blood components in a rotating chamber for collection |
US5807492A (en) * | 1987-01-30 | 1998-09-15 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cell |
US5792372A (en) * | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US5370802A (en) * | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
US6511411B1 (en) | 1987-01-30 | 2003-01-28 | Baxter International Inc. | Compact enhanced yield blood processing systems |
US5494578A (en) * | 1987-01-30 | 1996-02-27 | Baxter International Inc. | Centrifugation pheresis system |
US5529691A (en) * | 1987-01-30 | 1996-06-25 | Baxter International Inc. | Enhanced yield platelet collection systems and method |
US5076911A (en) * | 1987-01-30 | 1991-12-31 | Baxter International Inc. | Centrifugation chamber having an interface detection surface |
US4940543A (en) * | 1987-01-30 | 1990-07-10 | Baxter International Inc. | Plasma collection set |
US4834890A (en) * | 1987-01-30 | 1989-05-30 | Baxter International Inc. | Centrifugation pheresis system |
US5322620A (en) * | 1987-01-30 | 1994-06-21 | Baxter International Inc. | Centrifugation system having an interface detection surface |
US6071423A (en) * | 1987-01-30 | 2000-06-06 | Baxter International Inc. | Methods of collecting a blood plasma constituent |
US6780333B1 (en) | 1987-01-30 | 2004-08-24 | Baxter International Inc. | Centrifugation pheresis method |
US5656163A (en) * | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
US20030102272A1 (en) * | 1987-01-30 | 2003-06-05 | Baxter International Inc. | Blood processing systems and methods |
US5693232A (en) * | 1987-01-30 | 1997-12-02 | Baxter International Inc. | Method for collecting a blood component concentration |
US6899666B2 (en) | 1987-01-30 | 2005-05-31 | Baxter International Inc. | Blood processing systems and methods |
US5641414A (en) * | 1987-01-30 | 1997-06-24 | Baxter International Inc. | Blood processing systems and methods which restrict in flow of whole blood to increase platelet yields |
US5993370A (en) * | 1987-01-30 | 1999-11-30 | Baxter International Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US4936820A (en) * | 1988-10-07 | 1990-06-26 | Baxter International Inc. | High volume centrifugal fluid processing system and method for cultured cell suspensions and the like |
US5078671A (en) * | 1988-10-07 | 1992-01-07 | Baxter International Inc. | Centrifugal fluid processing system and method |
US5316667A (en) * | 1989-05-26 | 1994-05-31 | Baxter International Inc. | Time based interface detection systems for blood processing apparatus |
US5690835A (en) * | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US5549834A (en) * | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5362291A (en) * | 1991-12-23 | 1994-11-08 | Baxter International Inc. | Centrifugal processing system with direct access drawer |
US5804079A (en) * | 1991-12-23 | 1998-09-08 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
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Also Published As
Publication number | Publication date |
---|---|
FR2392725B1 (US06534493-20030318-C00166.png) | 1983-01-14 |
JPS5844419B2 (ja) | 1983-10-03 |
FR2392725A1 (fr) | 1978-12-29 |
IT7823825A0 (it) | 1978-05-26 |
IT1109801B (it) | 1985-12-23 |
JPS5748349A (en) | 1982-03-19 |
DE2821056C2 (de) | 1987-05-14 |
ZA782114B (en) | 1979-11-28 |
CA1206937A (en) | 1986-07-02 |
JPS542571A (en) | 1979-01-10 |
GB1563778A (en) | 1980-04-02 |
DE2821056A1 (de) | 1978-12-14 |
CH634236A5 (de) | 1983-01-31 |
ES469709A1 (es) | 1979-01-16 |
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