US4066362A - Apparatus and method for performing photometric analysis - Google Patents

Apparatus and method for performing photometric analysis Download PDF

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Publication number
US4066362A
US4066362A US04/753,200 US75320068A US4066362A US 4066362 A US4066362 A US 4066362A US 75320068 A US75320068 A US 75320068A US 4066362 A US4066362 A US 4066362A
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Prior art keywords
radiation
fluid
cell
container
source
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Expired - Lifetime
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US04/753,200
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English (en)
Inventor
Elbert P. Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
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EI Du Pont de Nemours and Co
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Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to US04/753,200 priority Critical patent/US4066362A/en
Priority to CA058,700A priority patent/CA954328A/en
Priority to DE1941572A priority patent/DE1941572C3/de
Priority to NL696912368A priority patent/NL147857B/xx
Priority to FR6928136A priority patent/FR2015814A1/fr
Priority to SE11322/69A priority patent/SE367254B/xx
Priority to GB40671/69A priority patent/GB1281952A/en
Priority to JP44064495A priority patent/JPS4835397B1/ja
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • B01L3/5453—Labware with identification means for laboratory containers for test tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack

Definitions

  • This invention is particularly related to the subject matter of application Ser. No. 545,494 filed on 4/26/66 entitled Analytic Test Pack and Process for Analysis by D. R. Johnson et al (assigned to the assignee of the present application), in that the Analytic Test Pack described and claimed therein may be used to provide the sample cell of the instant invention. It is also related to the subject matter of application Ser. No. 753,197 filed on the same day as this invention entitled Analytic Clinical Analayzer by inventors E. P. Carter, et al (assigned to the assignee of the present application), in that the instant invention may be used in the system described and claimed therein to perform the photometric analysis on the test solution.
  • These cross references are merely intended to illustrate and are not to restrict the scope and/or use of any of these inventions.
  • Photometric means have been used to perform chemical analysis on fluids for many years. Indeed photometers have now become an integral part of most chemical analysis equipment; particularly automatic analytic equipment. These instruments use various means to isolate the test sample into a specific region for measurement. Usually a rigid container called a cuvette, which is transparent to radiation within the frequency range required for the analysis, is used. The cuvette is subjected to radiation and the intensity of the radiation transmitted through the cuvette is monitored by a photocell.
  • a positive identification is much to be preferred, especially when such an identification can be used to control the operation of the instrument.
  • a cuvette is usually open to the air and, therefore, susceptible to contamination. Even if this problem is overcome, the cuvette has to be cleaned after each use or the next samples deposited in it will become contaminated. This is an expensive and time consuming procedure which could profitably be eliminated.
  • the use of a cuvette is a very inefficient way to utilize sample fluid since more fluid than is actually necessary for the analysis must be deposited in the cuvette.
  • a deformable container such as that used in the Analytic Test Pack described and claimed in application Ser. No. 545,494 is used.
  • the reagents are prepackaged in this container so that only the sample fluid and necessary buffer solution need be transferred to the pack when it is in the instrument.
  • the container is completely closed and disposable so that the probability of contamination is kept to a minimum, and cleaning is unnecessary.
  • the test to be run can be positively identified on the container, and this identification can be used to program the operation of the instrument at each stage of the analysis.
  • the subject matter of the present invention is a novel apparatus and method for performing photometric analysis on a fluid contained in a deformable container.
  • a specific amount of sample fluid and buffer solution are first deposited in the deformable container, which is then sealed at the top by pressing the pack between sealing bars. All of the fluid in the pack is thus restricted to a small pouch at the bottom of the container.
  • This pouch is then squeezed between two jaws containing recessed windows.
  • the fluid in the pouch hydraulically deforms the sides of the pouch into the contour of the recess formed between the two jaws. Since the jaws are brought together until only the thickness of the plastic pouch separates them, except in the region of the recess, the majority of the fluid contained in the deformable container is forced into the recess. In this way, a sample cell of precise and reproducible dimensions is formed.
  • a pressure relief chamber is provided.
  • a contact fluid applicator can be provided.
  • the film, from which the deformable container is made generally contains imperfections which trap air between the windows and the film. There is reflection from the surfaces of these air bubbles. If the size and shape of the air bubbles remains constant, they provide a constant error for which compensation can be made. Under constant pressure from the jaws, however, the film flows so that the size and shape of the air bubbles change, introducing a variable error for which it is difficult if not impossible to compensate. To circumvent this problem, a contact fluid can be applied to the deformable container.
  • the apparatus comprises: a deformable container; a cell forming means adapted to form the deformable container into a sample cell with flat sides; an irradiating means; and a measurement photocell.
  • the cell forming means is further adapted to place said cell in the optical path between said irradiating means and said photocell.
  • the method comprises: placing a fluid in a deformable container; forming the container into a sample cell by squeezing it between two flat windows; wetting the interface between the container and the windows with a contact fluid to reduce flow in the film and improve optical contact; then subjecting the sample cell to radiation of fixed intensity and distinct but variable frequency, and measuring photometrically the intensity of the transmitted radiation.
  • FIG. 1 is one embodiment of a deformable container that can be used in this invention
  • FIG. 2 is another embodiment of a deformable container that can be used in this invention.
  • FIG. 3 is a schematic diagram of one embodiment of the present invention.
  • FIG. 1 is an illustration of one of the simplest embodiments of the deformable container used in this invention.
  • the container itself 11 can be made from any transparent deformable material, but it is usually a pliable polymeric material, preferably selected from any of the following materials: polymers of olefins, e.g., ethylene, propylene and copolymers with vinyl acetate, etc.; halogenated polymers, e.g., polymers of vinyl acetate, rubber hydrochloride, vinyl fluoride polymers, etc.; polyesters, e.g., polyethylene terephthalate, ionomer resins, etc.; or laminate thereof.
  • the word transparent means transparent to the particular radiation employed in the photometric device.
  • the container should be made from a material transparent to ultraviolet radiation as well as visible light, since many of the analyses performed use ultraviolet light.
  • the container shown in FIG. 1 is a sack with an opening 12, through which the fluid to be tested 13 can be introduced.
  • the container 11 is only partially filled, so that there is an air space 14 above the fluid, but it is advantageous to keep the size of this air space to a minimum.
  • FIG. 2 A more sophisticated design of the deformable container, which is the subject of application Ser. No. 545,494 noted above, is illustrated in FIG. 2.
  • This container comprises a deformable pouch 15, made from some pliable polymeric material such as Surlyn®, and a header 16 made from a non deformable material.
  • This header may, optionally, contain some identification symbols 17, for visual identification, and some identification marks 18 which can be read and decoded photometrically. These identification marks 18 are useful not only to identify the test but also as a means of programming the operation of the instrument, as will be shown below.
  • the identification marks can be raised portions of the header which can be decoded mechanically; or any other suitable identification marks.
  • the header also contains an opening 19, through which the fluid to be analyzed can be introduced into the deformable pouch through inlet 20.
  • the fluid to be analyzed may be introduced through the opening 21 so that it passes through a separation column 22 before entering the pouch at 20.
  • the separation column can be an ion exchange column, a filter, or any other device needed in the analysis.
  • the deformable pouch 15 is composed of a reaction chamber 23 and a number of dimples 24, 25, 26 and 27, separated from the reaction chamber by rupturable seals. The dimples contain reagents which can be introduced into the reaction chamber at will, by merely rupturing those seals.
  • the two described embodiments of the deformable container are only illustrative of the possible simplicity or complexity of the container, and are not meant to be restrictive.
  • FIG. 3a is a schematic diagram of one embodiment of the photometer itself. It comprises an irradiating means, A, a cell forming means, B, and a measurement means, C.
  • the measurement means, C is a measurement photocell 28, of any design suitable for the purpose, which is responsive to visible, ultraviolet, and near infrared radiation. However, any detection means responsive to the particular radiation can be used.
  • the essential part of the irradiating means, A is an irradiation source. In this embodiment it is a suitable lamp 29, such as a quartz iodine lamp. The lamp should give a reasonable intensity of radiation over the frequency range desired.
  • any other source of radiation for producing the frequency of radiation required in the analysis can be used.
  • the light may be collimated, by collimators 30 and 31, and focused by lens 32.
  • the desired frequency is selected by passing the light through a filter 33.
  • This filter can be variable.
  • One simple way of making it variable is to have a plurality of filters in a filter wheel 34 which can be rotated, either automatically or manually, until the desired filter is in place.
  • the intensity of the radiation will vary as a function of frequency, it is desirable, but not necessary to include some device to maintain a constant intensity at the sample, no matter what the frequency might be.
  • One way of accomplishing this is to use a beam splitter 35 and a regulating photocell 36.
  • the beam splitter can be a partially silvered mirror which transmits a portion of the light incident on it, and reflects the rest. Usually such mirrors transmit 90 percent of the radiation and reflect 10 percent, but any reasonable ratio is suitable.
  • the reflected beam is then made incident on the regulator photocell 36 so that any variation in the intensity of the light that arrives at the mirror will be detected by the photocell.
  • this information can be fed to the power supply of the lamp 29, and the amount of power supplied to the lamp can be varied to compensate for the variation.
  • the irradiating means, A, and measurement means, C are necessary and indispensable features of any photometer; well known to those skilled in the art.
  • the critical feature of the present invention lies in the cell-forming means, which adapts the photometer for use with a deformable sample container in a way such that the most effective use is made of sample fluid in that container.
  • the cell-forming means comprises a pair of movable jaws 37 and 38, into which a pair of windows 39 and 40 are recessed.
  • the windows are flat windows made from quartz or any other suitable material.
  • the sealing bar acts to seal off the sample container so that the bottom of the sample container forms a sealed pouch containing the majority of the fluid which was deposited in the sample container.
  • the seal is made below the dimples, if any are present, to avoid deformed film near the ruptured seals. The seal closes off the pouch at the bottom of the test container so that when pressure is exerted on this pouch none of the fluid contained in it will escape.
  • the jaws of the cell-forming means are brought together so that only the thickness of the film which makes up the wall of the deformable container separates them, except in the region of the recess 42. In this embodiment, the jaws exert a pressure of approximately 100 psi on the pouch, forcing the fluid into the area of the recess.
  • the sample container is filled with exactly 5.0 ml. of fluid, and the recess is designed to form a sample cell which is exactly 1.0 cm. in length and 2.0 cm. in diameter at the window.
  • the cell broadens slightly at the center, so that the sample cell will hold approximately 3.8 ml. of fluid.
  • a pressure relief chamber 43 is included, and connected to the cell-forming chamber 42 by a narrow channel 44. The excess fluid, which could cause variations in cell length, is then deposited in the relief chamber, so that in this embodiment the length of the sample cell is reproducible to within 0.25 percent.
  • the deformable container is forced into the contours of the depression in the movable jaws. Since the walls of this depression are made from flat quartz plates, the surface of the container becomes flat. The problem of reflection at the film-air-quartz interface still remains, however. Films generally contain imperfections, and these imperfections cause air bubbles to be formed between the film and the windows. There are two surfaces of the air bubble from which reflection can take place. This in itself would not be of too much concern if the size and shape of the air bubbles remained constant. In such a case the error would be constant, and the area of the sample cell presented to the radiation could be made large enough so that the constant error is small. Under the constant pressure from the jaws, however, the film flows and the size and shape of the air bubbles change, introducing a variable error.
  • a contact fluid-injecting means can be included.
  • One way to inject contact fluid would be to provide input conduits 57 and 58 and outlet conduits 59 and 60 in jaws 37 and 38, respectively, so that contact fluid can be inserted into the space between the sample container and the windows through conduit 57 and 58, and excess fluid can be drained out through conduits 59 and 60.
  • the device merely deposits a contact fluid, such as water, on the surface of the deformable container so that the space between the sample container and the windows, in the region of the film imperfection, is filled with the contact fluid rather than with air. This inhibits changes in the dimension of the area around the flaw and, at the very least, converts the variable error to a constant error.
  • the contact fluid also improves optical contact between the windows and the sample container, so that the amount of reflection is decreased. In this embodiment, stray light into the photocell is less than 0.01 percent of the normal beam intensity after filtering.
  • the container of FIG. 2 has an identification code 18 on its header 16. If the analytic instrument is designed properly, presentation of this code at various stages in the operation will program the instrument as to the steps which it must follow. Such an instrument with complex logic and programming stages is the subject of patent application Ser No. 753,197.
  • the photometer of FIG. 3 can, optionally, include an identification means, 45 which is positioned above the header of the deformable container when the container is in the proper position within the photometer.
  • FIG. 3b is an enlarged view of that portion of FIG. 3a which includes the header of the deformable container and the identification means.
  • the header has a five space identification mark on it, and the identification means is a set of five photodiodes.
  • Light from a lamp 46 in FIG. 3a is reflected through the header into the photodiodes, through the identification code.
  • the identification code In this case, where there are two dark spaces 47 and 50, and three blank spaces 48, 49 and 51, the light reaching the photodiodes 52 and 55 is less intense than the light reaching photodiodes 53, 54 and 55 through the unoccupied identification spaces.
  • the pattern detected by the photodiodes identifies the sample, and a signal corresponding to this identification is sent to the programming section of the machine which determines what steps the photometer system is to take.
  • the identification means can be a simple dark-light identification or it can be a sophisticated character recognition identification means, depending on the needs of the particular device.
  • the first step is the closing of jaws 37 and 38, sealing off the container 15 by means of the sealing bar 41.
  • the fluid forces the container into the shape of the cell-forming region.
  • Contact fluid is sprayed on the interface between the windows 39 and 40 and the container.
  • a sample cell has been formed which is in optical contact with two flat windows.
  • Excess fluid is forced into the pressure relief chamber, so that a sample cell with precise dimensions is formed.
  • this step leaves the fluid in a turbulent state, and it is best to allow this turbulence to subside. Fifteen seconds is generally enough time for this to occur.
  • the identification means While the turbulence is subsiding, the identification means has identified the test to be run, the proper frequency of radiation is chosen by rotating the filter wheel until the proper filter is in place, and the regulating photocell has adjusted the power supplied to the radiation source so that the intensity of the light passing through the filter is maintained at the operative level.
  • the measurement photocell measures transmission for a short time interval (about 1 sec.) then waits for a time interval (about 17 sec.) before it makes a second measure of transmission.
  • the difference in transmission is the output of the photometer. This difference can either be read directly, displayed by some conventional means, or sent to the logic and programming stages of an analyzing instrument, as described in application Ser. No. 753,197, to be interpreted and indexed with other information about the particular test.

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  • Health & Medical Sciences (AREA)
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  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
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US04/753,200 1968-08-16 1968-08-16 Apparatus and method for performing photometric analysis Expired - Lifetime US4066362A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US04/753,200 US4066362A (en) 1968-08-16 1968-08-16 Apparatus and method for performing photometric analysis
CA058,700A CA954328A (en) 1968-08-16 1969-08-05 Apparatus and method for performing photometric analysis
NL696912368A NL147857B (nl) 1968-08-16 1969-08-14 Samenstel voor het fotometrisch analyseren van een vloeistof in een vervormbare houder.
FR6928136A FR2015814A1 (xx) 1968-08-16 1969-08-14
DE1941572A DE1941572C3 (de) 1968-08-16 1969-08-14 Vorrichtung für die photometrische Analyse eines in einem deformierbaren Behälter enthaltenen Fluids
SE11322/69A SE367254B (xx) 1968-08-16 1969-08-14
GB40671/69A GB1281952A (en) 1968-08-16 1969-08-14 Apparatus and method for performing photometric analysis
JP44064495A JPS4835397B1 (xx) 1968-08-16 1969-08-16

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US04/753,200 US4066362A (en) 1968-08-16 1968-08-16 Apparatus and method for performing photometric analysis

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JP (1) JPS4835397B1 (xx)
CA (1) CA954328A (xx)
DE (1) DE1941572C3 (xx)
FR (1) FR2015814A1 (xx)
GB (1) GB1281952A (xx)
NL (1) NL147857B (xx)
SE (1) SE367254B (xx)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286881A (en) * 1979-02-26 1981-09-01 Phillips Petroleum Company Sample cell
US4312593A (en) * 1979-12-21 1982-01-26 E. I. Du Pont De Nemours And Company Direct readout apparatus for measuring light transmitted through liquids
US4519710A (en) * 1983-03-21 1985-05-28 Lockheed Missiles & Space Company, Inc. Colorimeter
US4542008A (en) * 1983-10-03 1985-09-17 Olin Corporation Electrochemical chlorine dioxide process
EP0055756B1 (en) * 1980-07-11 1986-03-26 Eflab Oy Photometer
US4601582A (en) * 1983-01-03 1986-07-22 Milton Roy Company Spectrophotometer
US4643877A (en) * 1983-08-12 1987-02-17 Max Planck Gesellschaft Zur Foerderung Der Wissenschaften Fluorometer
US4862001A (en) * 1988-01-07 1989-08-29 Texaco Inc. Radiant energy absorption steam quality monitoring means and method
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5386287A (en) * 1991-03-20 1995-01-31 Dr. Bruno Lange Gmbh Device for automatically evaluating a plurality of probe ingredients by means of chemical sensors
US5616457A (en) * 1995-02-08 1997-04-01 University Of South Florida Method and apparatus for the detection and classification of microorganisms in water
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6493085B1 (en) * 2000-05-24 2002-12-10 Microcensus, Llc Light analyzer apparatus
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US20060103848A1 (en) * 2004-11-18 2006-05-18 Ushiodenki Kabushiki Kaisha Absorption spectrum photometry microchip testing device and components thereof
US20100208269A1 (en) * 2007-07-20 2010-08-19 Toyota Jidosha Kabushiki Kaisha Particle concentration detecting device
US20120127470A1 (en) * 2010-11-21 2012-05-24 Reach Devices Optical System Design for Wide Range Optical Density Measurements
CN109548202A (zh) * 2018-11-16 2019-03-29 西安交通大学 一种大面积静态石英灯模块化可调加热装置
EP3495799A3 (en) * 2012-07-25 2020-11-18 Labrador Diagnostics LLC A method for measurement of a component in cells
US12111248B2 (en) 2013-02-18 2024-10-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples

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Publication number Priority date Publication date Assignee Title
AT520151B1 (de) * 2017-07-14 2020-10-15 Meon Medical Solutions Gmbh & Co Kg Analysator und verfahren zur durchführung von chemischen, biochemischen und/oder immunchemischen analysen

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US2442462A (en) * 1943-12-13 1948-06-01 Harry M Kirschbaum Apparatus responsive to variations in the light transmission of blood of living animals for indicating variations in the oxygen content thereof
US2706927A (en) * 1949-08-04 1955-04-26 Research Corp Apparatus for determining percentage oxygen-saturation of blood
US3152587A (en) * 1960-03-31 1964-10-13 Hellige & Co Gmbh F Medical photometric apparatus
US3286583A (en) * 1962-06-22 1966-11-22 Technicon Instr Colorimeter flow cell and holder
US3415997A (en) * 1964-06-04 1968-12-10 Bayer Ag Radiation sensitive ampoule testing apparatus and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2442462A (en) * 1943-12-13 1948-06-01 Harry M Kirschbaum Apparatus responsive to variations in the light transmission of blood of living animals for indicating variations in the oxygen content thereof
US2706927A (en) * 1949-08-04 1955-04-26 Research Corp Apparatus for determining percentage oxygen-saturation of blood
US3152587A (en) * 1960-03-31 1964-10-13 Hellige & Co Gmbh F Medical photometric apparatus
US3286583A (en) * 1962-06-22 1966-11-22 Technicon Instr Colorimeter flow cell and holder
US3415997A (en) * 1964-06-04 1968-12-10 Bayer Ag Radiation sensitive ampoule testing apparatus and method

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286881A (en) * 1979-02-26 1981-09-01 Phillips Petroleum Company Sample cell
US4312593A (en) * 1979-12-21 1982-01-26 E. I. Du Pont De Nemours And Company Direct readout apparatus for measuring light transmitted through liquids
EP0055756B1 (en) * 1980-07-11 1986-03-26 Eflab Oy Photometer
US4601582A (en) * 1983-01-03 1986-07-22 Milton Roy Company Spectrophotometer
US4519710A (en) * 1983-03-21 1985-05-28 Lockheed Missiles & Space Company, Inc. Colorimeter
US4643877A (en) * 1983-08-12 1987-02-17 Max Planck Gesellschaft Zur Foerderung Der Wissenschaften Fluorometer
US4542008A (en) * 1983-10-03 1985-09-17 Olin Corporation Electrochemical chlorine dioxide process
US4862001A (en) * 1988-01-07 1989-08-29 Texaco Inc. Radiant energy absorption steam quality monitoring means and method
US5192510A (en) * 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
WO1993018405A1 (en) * 1991-01-30 1993-09-16 Du Pont Apparatus for performing assays using evanescent waves
US5300423A (en) * 1991-01-30 1994-04-05 E. I. Du Pont De Nemours And Company Specific binding assay involving separation of light emissions
US5386287A (en) * 1991-03-20 1995-01-31 Dr. Bruno Lange Gmbh Device for automatically evaluating a plurality of probe ingredients by means of chemical sensors
US5616457A (en) * 1995-02-08 1997-04-01 University Of South Florida Method and apparatus for the detection and classification of microorganisms in water
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6493085B1 (en) * 2000-05-24 2002-12-10 Microcensus, Llc Light analyzer apparatus
US6762842B2 (en) 2000-05-24 2004-07-13 Microcensus, Llc Light analyzer apparatus
US20030072000A1 (en) * 2000-05-24 2003-04-17 Microcensus, Llc Light analyzer apparatus
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US20030138356A1 (en) * 2001-02-28 2003-07-24 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US20060103848A1 (en) * 2004-11-18 2006-05-18 Ushiodenki Kabushiki Kaisha Absorption spectrum photometry microchip testing device and components thereof
US7443502B2 (en) * 2004-11-18 2008-10-28 Ushiodenki Kabushiki Kaisha Absorption spectrum photometry microchip testing device and components thereof
US8139224B2 (en) * 2007-07-20 2012-03-20 Toyota Jidosha Kabushiki Kaisha Particle concentration detecting device
US20100208269A1 (en) * 2007-07-20 2010-08-19 Toyota Jidosha Kabushiki Kaisha Particle concentration detecting device
US20120127470A1 (en) * 2010-11-21 2012-05-24 Reach Devices Optical System Design for Wide Range Optical Density Measurements
US8570521B2 (en) * 2010-11-21 2013-10-29 Reach Devices, LLC Optical system design for wide range optical density measurements
EP3495799A3 (en) * 2012-07-25 2020-11-18 Labrador Diagnostics LLC A method for measurement of a component in cells
US11300564B2 (en) 2012-07-25 2022-04-12 Labrador Diagnostics Llc Image analysis and measurement of biological samples
US12066440B2 (en) 2012-07-25 2024-08-20 Labrador Diagnostics Llc Image analysis and measurement of biological samples
US12111248B2 (en) 2013-02-18 2024-10-08 Labrador Diagnostics Llc Image analysis and measurement of biological samples
CN109548202A (zh) * 2018-11-16 2019-03-29 西安交通大学 一种大面积静态石英灯模块化可调加热装置
CN109548202B (zh) * 2018-11-16 2020-08-18 西安交通大学 一种大面积静态石英灯模块化可调加热装置

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SE367254B (xx) 1974-05-20
DE1941572A1 (de) 1970-02-19
NL147857B (nl) 1975-11-17
CA954328A (en) 1974-09-10
DE1941572B2 (de) 1977-08-18
DE1941572C3 (de) 1978-05-03
JPS4835397B1 (xx) 1973-10-27
GB1281952A (en) 1972-07-19
FR2015814A1 (xx) 1970-04-30
NL6912368A (xx) 1970-02-18

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