US3918449A - Device for cutaneous therapeutic treatment - Google Patents

Device for cutaneous therapeutic treatment Download PDF

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Publication number
US3918449A
US3918449A US476531A US47653174A US3918449A US 3918449 A US3918449 A US 3918449A US 476531 A US476531 A US 476531A US 47653174 A US47653174 A US 47653174A US 3918449 A US3918449 A US 3918449A
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United States
Prior art keywords
shaft
rotary means
projections
skin
syringe
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US476531A
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English (en)
Inventor
Michel Louis Paul Pistor
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Etablissements A Guerin
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Etablissements A Guerin
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Definitions

  • ABSTRACT A device for cutaneous therapeutic treatment comprising cutaneous micro-puncturing structure in combination with structure for delivering a treatment product onto the outer surface of said micropuncturing structure and/or onto the skin area treated thereby.
  • the present invention relates essentially to a device for cutaneous therapeutic or curative treatment enabling to perform an outstandingly improved action of medicines usually applied onto the skin in particular for invigourating or strengthening and revitilizing it or for suppressing the infections affecting same.
  • This device is characterized in that it comprises cutaneous micro-puncturing means associated with means for delivering the treatment product.
  • This device enables to form micro-wounds on the skin and to apply at the same time the treatment product thereon.
  • These cutaneous micro-puncturing means consist preferably of a plurality of points, needles or the like mounted on the device so that they may be more or less driven into the skin according to the nature of the treatment.
  • the treatment product used may for instance consist:
  • the skin is irritated: of a cortisone-based liquid or ointment or salve;
  • the skin is infected: of an antibiotics-based liquid or ointment or salve corresponding to the possible indications of the antibiogram, preferably in associated with a vaccine in order to locally mobilize a large number of anti-bodies;
  • the skin is dry and sclerosed or hardened: of an ointment rich in sea-water, in vitamins and in vaso-dilator agents, etc.
  • said device comprises:
  • a support or holder comprising at least a first part wherein is accommodated or housed said shaft, a second part preferably arranged in parallel relation to that shaft and including a plurality of discharge holes or ports for delivering the treatment product and a third part forming a connecting fitting or fastening or securing said syringe, said discharge holes being in communication with said fitting through suitable channels or like ducts or passageways.
  • the points or sharp pins. needles or the like would advantageously be mounted ac cording to the present invention at the periphery or about a plurality of independent rollers or like small wheels; according to another form of embodiment and according to the present invention said points or sharp pins, needles or the like would be mounted onto the lateral surface of side of an elongated cylinder.
  • the element or elements carrying said points or sharp pins, needles or the like are loosely mounted onto the shaft which carries same thereby to have all of the points.
  • sharp pins or needles may be driven in more or less according to the object sought or goal aimed at; these points, sharp pins or needles will be given in particular a length of about 1 millimeter which would then represent the greatest depth of the mechanical preparatory treatment afterwards enabling a more effective action of the treatment product.
  • the practitioner will be able to achieve a positive result more quickly and more easily with the treatment prod uct as the penetration and the diffusion of this product will take place muchbetter than in the case of a mere application without. any micro-puncturing operation since the transcutaneous passage of a therapeutic ointment or liquid is often problematical or questionable.
  • the treatment by means of the device of the present invention may in particular be carried out:
  • the device according to the present invention enables to obtain a much better therapeutic action for instance in the case of humpy or nodulated skins swollen by cellulitus or exhibiting striations, scars or cutaneous devitilized ulcerations. let alone all the skin diseases where the epidermis usually raises a barrier against the usual local therapeutics.
  • FIG. 1 shows an elevational front view of said device with parts broken away
  • FIG. 2 shows a side view looking in the direction of the arrow F in FIG. 1, of this device.
  • FIG. 3 shows a perspective view of a roller or small wheel of the device shown in FIGS. 1 and 2.
  • the device shown in FIGS. 1 and 2 comprises:
  • a bent or cranked holder or support 1 including a first portion 10 formed with a tapped bore 3 and a second portion 1b onto which is secured for instance through a screw threaded connection a pipe fitting 1c adapted to receive or accommodate an injection syringe;
  • the injection syringe 2 comprising a syringe body or barrel 2a, a syringe piston or plunger 2b and a tip portion or end member 20 of a kind adapted to co-operate with the pipe fitting 1c of the holder 1;
  • a shaft 4 terminating in a head 4a of a diameter larger than that of the shank of the shaft and the outer surface of which is knurled or milled, that end 412 of said shaft which is opposite from the head 40 being screwthreaded and of smaller diameter than the shank portion of said shaft (not seen in the Figures), this screwthrcaded end 412 being screwed into the tapped bore 3 3 of the holder 1;
  • rollers or small wheels a plurality of independent rollers or small wheels (four in the example shown) designated by the reference numerals 5a, 5b, 5c and 5d, respectively, the periphery of each one of these rollers being provided with small points, sharp pins or needles 9 of a length of about 1 millimeter (the diameter of the rollers being of the order of magnitude of mm).
  • each roller comprises in the present instance eight points or sharp pins of this kind which preferably have been inserted and secured onto the bodies of said rollers.
  • These rollers are independent from each other as stated hereinabove and they are freely rotatable about the shaft 4 which is stationary in rotation when said rollers run or ride onto the skin surface in view of the friction motion imparted to the apparatus.
  • the second portion lb of the holder 1 comprises a network or system 6 of fine channels or ducts terminating at the surface of said second portion located in front of the rollers 5, in a plurality of holes or like ports 7a, 7b, 7c and 7d, respectively, each one of which is located in front of a corresponding roller 50, 5b, 5c and 5d, respectively, the network or system 6 communicating moreover with the axial duct 8 of the pipe fitting 1c.
  • the several rollers 5u-5d constitute a rotary means supported for rotary movement by the shaft 4 and provided at its outer periphery with the several sharply pointed small projections 9 which are circumferentially and axially distributed with respect to the shaft 4.
  • the shaft 4 extends parallel to the elongated body lb to which the shaft 4 is fixed with this body lb being formed with the network 6 of channels or ducts which include a longitudinal bore extending longitudinally along the interior of the body lb which is parallel to the shaft 4, this longitudinal bore communicating on one side with the plurality of ports 7a-7d which are respectively aligned with the circles along which the several sharply pointed projections 9 are distributed on the peripheries of the rollers 5(1-5d, while on the other side the longitudinal bore is in communication with the axial bore of the fitting means 11' which is fixed to the body lb at the side thereof opposite from the rotary means 5a5d and which serves as a connecting means for connecting to the body lb the syringe 2 in such a way that the interior of the syringe 2 communicates with the longitudinal bore of the network 6.
  • the syringe 2 forms a handle by means of which it is possible for the practitioner to manipulate the device. controlling the pressure with which the sharply pointed projections 9 are applied to the skin as well as controlling the manner in which the unit formed by the body lb and the shaft 4 is drawn rectilinearly over an area of the skin to have micro-puncturing carried out by the sharply pointed projections 9 4 while the contents of the syringe are delivered from the ports 711-711 not only to the exterior surface of the rotary means 5a5zl in line with the circumferentially distributed rows of sharply pointed projections 9 but also directly onto the skin.
  • a cutaneous therapeutic treatment device comprising rotary means for rolling along a skin area which is to be treated and fixedly carrying at its exterior surface a plurality of sharply pointed projections for micro-puncturing the skin during rolling of said rotary means therealong, said projections being axially and circumferentially distributed over said exterior surface of said rotary means, a shaft extending through said rotary means and supporting the same for free rotary movement, an elongated body extending parallel to said shaft and means fixing said body to said shaft so that said shaft and body form a unitary structure, said exterior surface of said rotary means being situated between said shaft and elongated body while being spaced together with said projections from said elongated body, the latter being formed with an interior longitudinal bore and with a plurality of ports communicating with said bore and the exterior of said body and directed toward said exterior surface of said rotary means, a syringe, and connecting means connecting said syringe to said elongated body in a manner providing from said syringe a handle
  • said rotary means includes a plurality of independent rollers freely turnable on said shaft and each carrying a plurality of said projections which are distributed along a circular row.
  • each of said micro-puncturing projections extends from said exterior surface of said rotary means through a distance of approximately 1 mm.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US476531A 1973-06-06 1974-06-05 Device for cutaneous therapeutic treatment Expired - Lifetime US3918449A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7320594A FR2232331B1 (enrdf_load_stackoverflow) 1973-06-06 1973-06-06

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US3918449A true US3918449A (en) 1975-11-11

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US476531A Expired - Lifetime US3918449A (en) 1973-06-06 1974-06-05 Device for cutaneous therapeutic treatment

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DE (1) DE2427063A1 (enrdf_load_stackoverflow)
FR (1) FR2232331B1 (enrdf_load_stackoverflow)

Cited By (78)

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US5139029A (en) * 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
US5843114A (en) * 1994-05-23 1998-12-01 Samsung Electro-Mechanics Co., Ltd. Skin perforating apparatus for transdermal medication
US5964729A (en) * 1994-05-23 1999-10-12 Samsung Electro-Mechanics Co., Ltd. Perforating device for dermal administration
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US20020082543A1 (en) * 2000-12-14 2002-06-27 Jung-Hwan Park Microneedle devices and production thereof
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US20020177858A1 (en) * 2000-10-16 2002-11-28 Sherman Faiz Feisal Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US20030095582A1 (en) * 2000-12-21 2003-05-22 Ackley Donald E. Microneedle array systems
US20030135158A1 (en) * 2001-09-21 2003-07-17 Gonnelli Robert R. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20030135167A1 (en) * 2001-09-19 2003-07-17 Gonnelli Robert R. Microneedles, microneedle arrays, and systems and methods relating to same
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
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US20030181863A1 (en) * 2000-11-09 2003-09-25 Ackley Donald E. Microneedle adapter
US20030220656A1 (en) * 2002-05-24 2003-11-27 Vladimir Gartstein Method of exfoliation of skin using closely-packed microstructures
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20040143211A1 (en) * 2002-08-29 2004-07-22 Haider M. Ishaq Substance delivery via a rotating microabrading surface
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
WO2005042054A2 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
US20050136099A1 (en) * 2003-12-22 2005-06-23 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Exfoliating personal care wipe article
US20050149115A1 (en) * 1999-09-20 2005-07-07 Roue Chad C. Method of closing an opening in a wall of the heart
US6931277B1 (en) 1999-06-09 2005-08-16 The Procter & Gamble Company Intracutaneous microneedle array apparatus
WO2004045671A3 (en) * 2002-11-18 2006-02-16 Nano Pass Technologies Ltd Microstructure roller system
US20060041241A1 (en) * 2003-03-25 2006-02-23 Herndon Terry O Drill device and method for forming microconduits
US20060204562A1 (en) * 2005-02-16 2006-09-14 Cormier Michel J Microprojection arrays with improved biocompatibility
US20060253079A1 (en) * 2005-04-25 2006-11-09 Mcdonough Justin Stratum corneum piercing device
US20070088264A1 (en) * 2005-09-14 2007-04-19 Liebl Horst Device for introducing an active ingredient into the skin
US20070149991A1 (en) * 2005-12-22 2007-06-28 Spamedica International Srl Of Warrens Skin rejuvination resurfacing method
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
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US20090118698A1 (en) * 2000-12-20 2009-05-07 Edelgard Liebl Device and method for applying an active ingredient to the skin
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Cited By (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139029A (en) * 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
US5843114A (en) * 1994-05-23 1998-12-01 Samsung Electro-Mechanics Co., Ltd. Skin perforating apparatus for transdermal medication
US5964729A (en) * 1994-05-23 1999-10-12 Samsung Electro-Mechanics Co., Ltd. Perforating device for dermal administration
US6050988A (en) * 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US20020138049A1 (en) * 1998-06-10 2002-09-26 Allen Mark G. Microneedle devices and methods of manufacture and use thereof
US8708966B2 (en) * 1998-06-10 2014-04-29 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6334856B1 (en) 1998-06-10 2002-01-01 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7226439B2 (en) 1999-06-04 2007-06-05 Georgia Tech Research Corporation Microneedle drug delivery device
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US8257324B2 (en) 1999-06-04 2012-09-04 Georgia Tech Research Corporation Microneedle drug delivery device
US20070225676A1 (en) * 1999-06-04 2007-09-27 Prausnitz Mark R Microneedle drug delivery device
US6931277B1 (en) 1999-06-09 2005-08-16 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US7416541B2 (en) 1999-06-09 2008-08-26 Corium International, Inc. Intracutaneous microneedle array apparatus
US20050149115A1 (en) * 1999-09-20 2005-07-07 Roue Chad C. Method of closing an opening in a wall of the heart
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US20020177858A1 (en) * 2000-10-16 2002-11-28 Sherman Faiz Feisal Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US20060149297A1 (en) * 2000-10-16 2006-07-06 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
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FR2232331A1 (enrdf_load_stackoverflow) 1975-01-03
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