US3902490A - Portable artificial kidney system - Google Patents

Portable artificial kidney system Download PDF

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Publication number
US3902490A
US3902490A US455179A US45517974A US3902490A US 3902490 A US3902490 A US 3902490A US 455179 A US455179 A US 455179A US 45517974 A US45517974 A US 45517974A US 3902490 A US3902490 A US 3902490A
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United States
Prior art keywords
dialysate
blood
solution
transporting
pump
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Expired - Lifetime
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US455179A
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English (en)
Inventor
Stephen C Jacobsen
Clifford Kwan-Gett
Willem J Kolff
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University of Utah
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University of Utah
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Priority to US455179A priority Critical patent/US3902490A/en
Priority to CH344075A priority patent/CH592455A5/xx
Priority to SE7503199A priority patent/SE7503199L/xx
Priority to GB12254/75A priority patent/GB1510129A/en
Priority to JP50035045A priority patent/JPS50133697A/ja
Priority to FR7509352A priority patent/FR2274803A1/fr
Priority to BE154808A priority patent/BE827225A/xx
Priority to IT21691/75A priority patent/IT1034615B/it
Priority to CA223,140A priority patent/CA1072883A/en
Priority to SU7502117221A priority patent/SU581844A3/ru
Priority to DE19752513489 priority patent/DE2513489A1/de
Application granted granted Critical
Publication of US3902490A publication Critical patent/US3902490A/en
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/086—Machines, pumps, or pumping installations having flexible working members having tubular flexible members with two or more tubular flexible members in parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1649—Constructional aspects thereof with pulsatile dialysis fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/302—Details having a reservoir for withdrawn untreated blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/304—Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
    • A61M1/301—Details
    • A61M1/305—Control of inversion point between collection and re-infusion phase
    • A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/37—Haemodialysis, haemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/438—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being mechanical
    • A61M60/441—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being mechanical generated by an electromotor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/562—Electronic control means, e.g. for feedback regulation for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/835—Constructional details other than related to driving of positive displacement blood pumps
    • A61M60/837—Aspects of flexible displacement members, e.g. shapes or materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/849—Disposable parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/851—Valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/89—Valves
    • A61M60/892—Active valves, i.e. actuated by an external force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/89—Valves
    • A61M60/894—Passive valves, i.e. valves actuated by the blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S210/00—Liquid purification or separation
    • Y10S210/929—Hemoultrafiltrate volume measurement or control processes

Definitions

  • An artificial kidney system includes a dialyzer element through which blood of a patient and dialysate solution are circulated to enable transfer of waste, electrolytes, water and other components from the blood to the solution (and in some cases from the solution to the blood), blood pump and circulation apparatus for withdrawing blood from the patient and applying it to the dialyzer element and for returning blood from the dialyzer element to the patient, and dialysate pump and circulation apparatus for transporting dialysate solution from a dialysate source to the dialyzer element and from the dialyzer element to a dialysate sink.
  • the blood and the dialysate pump apparatus each includes a flexible casing which, when compressed, forces fluid from the casing and which, when released, draws fluid into the casing.
  • the dialysate circulation apparatus includes a variable volume accumulator jacket for receiving dialysate solution when the pump casing is compressed and for discharging dialysate solution when the pump casing is released.
  • a pump actuator operates the blood pump apparatus and the dialysate pump apparatus to circulate blood and dialysate solution through the dialyzer element.
  • FIG. 2 DIALYZER ELEMENT BLOOD SYSTEM 2
  • FIG. 4A is a diagrammatic representation of FIG. 4A
  • This invention relates to artificial kidney systems and more particularly to a compact. portable and light weight artificial kidney.
  • a specific illustrative embodiment which includes a dialyzcr element through which blood of a pa ticnt and dialysatc solution are circulated to enable transfer of undesirable chemicals and water from the blood to the solution, a blood transporting system for transporting blood from the patient to the dialyzer element and from the dialyzcr element back to the patient.
  • a dialysatc transporting system for transporting dialysate solution to the dialyzcr element and from the dialyzcr element, and first and second pumps coupled into the blood transporting system and dialysatc transporting system for causing the blood and the dialysate solution to flow in the blood transporting system and dialysatc transporting system respectively.
  • the system also includes apparatus for operating both the first pump and the second pump to produce a pulsating pumping action for the blood and dialysatc solution.
  • each of the pumps includes a flexible casing which, when alternately compressed and released. develops the pressure and suction necessary to cause the blood and dialysate solution to flow in their respective transporting systems.
  • FIG. 1 is an overall diagrammatic showing of one illustrative embodiment of the present invention
  • FIG. 2 is a cross-sectional view of a pump of the type shown in FIG. 1;
  • FIG. 3 shows a cross-sectional view of the vacuum regulator of FIG. 1;
  • FIGS. 4A-4C show top views of the blood and dialysate solution pumps together with the pump actuator and retaining plates;
  • FIGS. SA-SC show end views of the blood and dialysate solution pumps also with the pump actuator and retaining plates;
  • FIGS. 6A and 6B show end. views of an alternative embodiment of the blood and dialysate solution pumps and pump actuator.
  • FIG. 7 shows a top view of the embodiment of FIGS. 6A and 6B with the pump casings compressed.
  • FIG. 8 shows a full-cycle pump made in accordance with the present invention.
  • FIG. 1 a diagrammatic view of the artificial-kidney system or hemodialyzer of the present invention is shown in FIG. 1.
  • the system generally includes a blood transporting system 2 through which blood of a patient is circulated and a dialysate transporting system 6 through which dialysate solution is circulated. Both the blood and the dialysate solution are circulated through a dialyzer element 38 where chemical wastes and water are transported from the blood by the process of diffusion. Blood is carried through the dialyzer element 38 by a bundle of hollow fiber strands (or other suitable membrane structure), respresented as a single tube 42 in FIG. I, which are immersed in dialysate solution contained in the dialyzer element.
  • dialyzer element 38 As the blood is carried through the dialyzer element 38, chemical wastes and water transfer through the thin walls of the fiber strands into the solution. This process of hemodialysis is well known in the art and has been performed by artificial kidney systems for a number ofyears. The construction of dialyzer elements is also known in the art.
  • the blood transporting system 2 includes tubing 4, a pump 14, and a single-needle cannula 18.
  • the cannula 18 is described more fully in copending application, Ser. No. 455,180.
  • the blood transporting system 2 could also be used with conventional doubleneedlc cannulas as well as the single-needle cannula.
  • the pump 14 causes blood to bc alternately withdrawn from and returned to the patient.
  • the pump 14 is coupled into the tubing 4 to provide the necessary pressure and suction for forcing the blood to circulate in the blood transporting system 2.
  • the pump 14 ineludes a flexible cylindrical-shaped casing 202 open at either end, an inlet check valve 210 coupled in one end of the casing, and an outlet check valve 202 coupled in the other end of the casing.
  • Each valve includes a valve seat (214 and 222) and a valve head (218 and 226) for controlling the flow of blood into and out of the pump casing 202.
  • the pump 14 of FIG. 2 is coupled into the blood circulation system 2 so that blood flows from the cannula 18 through the pump to the dialyzer element 38.
  • the casing 202 could have shapes other than the cylindrical shape illustrated so long as the pumping action, to be described hereafter, is carried out.
  • the pump 14 is operated by compressing the pump casing by means of a compression element 16 and then releasing the casing.
  • a motor 84 is mechanically coupled to the compression element 16 to cause it to alternately compress and release the casing.
  • blood in the pump will force check valve 30 to close and the check valve 34 to open so that blood will flow from the pump to the dialyzer element 38.
  • the pump casing is released the resiliency of the casing will cause it to resume its normal shape thereby creating a vacuum which forces check valve 34 to close and check valve 30 to open to thereby draw blood from the patient through the cannula 18 into the pump.
  • the valve 26 and pump 14 cooperate in a unique manner to provide a one-wayflow of blood through the blood transporting system 2.
  • the pressure of the blood in the tubing 4 and thus in the valve 26 increases to a value greater than the atmospheric pressure causing the valve 26 to open and allow blood to flow from the tubing in the dialyzer element 38, through the vlave 26 and the needle 22 back into the patient.
  • the pump casing When the pump casing is released, it creates a vacuum or negative pressure in the cannula 18 which is less then the atmospheric pressure so that the valve 26 is caused to close and blood is thereby withdrawn from the patient through the cannula 18 into the pump 14 and not from the tubing in the dialyzer element 38 through the valve 26 to the pump.
  • the pump 14 and valve 26 thus cooperate to alternately withdraw blood from the patient into the pump 14 and then force the blood from the pump 14 into dialyzer element 38 and from the dialyzer element 38 back through the valve 26 to the patient.
  • the cannula l8 and valve 26 are described fully in the aforecitcd copending application.
  • the pump 14 provides a non-occulsive pumping action which, unlike certain other pumps presently used in artificial kidney systems such as the roller pump, does very little damage to the blood during the pumping operation. (With the roller pump, blood caught between the walls of the tubing being rolled by the pump roller is oftentimes damaged.) Also. very little tubing is needed with the pump 14 so that the foreign surface area which the blood must contact during the dialysis process is minimized.
  • the casing of the pump 14 might illustratively be made of latex rubber, silicone rubber or other suitably resilient material.
  • a wall thickness of substantially oneeighth of an inch has been found suitable for the casing, using either latex rubber or silicone rubber, to develop the suction necessary to withdraw the blood from the patient.
  • the dialysate transporting system 6 of FIG. 1 provides for transporting dialysate solution from a dialysate source to the dialyzer element 38 and for transporting dialysate solution from the dialyzer element 38 to a dialysate sink.
  • a chemical removal canister 46 acts as both the dialysate source and dialysate sink.
  • the canister 46 contains a bed of activated charcoal particles and other chemical agents 48 for processing the dialysate solution as it flows through the canister.
  • the canister 46 is divided into a receiving compartment 50, into which dialysate solution is pumped from the dialyzer element 38, and a discharging compartment 54, from which dialysate solution is taken for transport to the dialyzer element 38.
  • Division of the canister 46 in this manner forces the dialyzer solution to flow through the charcoal particles and other chemical agents to thereby provide maxiumum processing of the dialysate solution.
  • the dialysate solution is pumped into the dialyzer element 38 to circulate about the hollow blood-carrying fibers represented by the tube 42 to facilitate the process of dialysis previously described.
  • dialysate source and sink are combined in the canister 46, it should be understood that the FIG. 1 system could he used with the conventional separate source and sink.
  • the dialysate transporting system 6 includes a pump 52, of similar construction as the pump 14 of the blood transporting system 2, for causing the dialysate solution to circulate through the dialyzer element 38.
  • the pump 52 is interposed in that portion of the dialysate transporting system which carries solution from the dialyzer element 38 to the canister 46.
  • the motor driven compression element 16 which operates pump 14 also operates pump 52.
  • the dialysate transporting system 6 also includes an accumulator 66, whose function will be explained momentarily, a collector 70, whose function will also be explained momentarily. and a vacuum regulator 74 by which the vacuum of the dialysate solution within the dialyzer 38 may be controlled.
  • the accumulator 66 is coupled into the dialysate transporting system 6 to receive dialysate solution when the pump 42 is compressed and then to discharge solution back into the system when the pump 42 is released.
  • the accumulator 66 in effect, accounts for the change in volume of the dialysate transporting system resulting from operation of the pump 42. (This is necessary because the dialysate transporting system 6 of FIG.
  • the accumulator 66 is a variable volume container and could, advantageously, be con structed of a flexible jacket whose walls expand and contract when dialysate solution is respectively received into and discharged from the accumulator.
  • the collector 70 is provided to receive excess solution produced as a result of the passage of chemicals and water from the blood into the dialysate solution in dialyzer element 38.
  • the chemicals and water passing from the blood into the dialysate solution increase the volume of the solution giving rise to a need for some means of accommodating this increase.
  • the collector 70 is coupled into the dialysate transporting system to receive and retain this excess fluid.
  • the collector 70 is a variable-volume container and, advantageously, is comprised of a collapsible disposable blad der, similar to a common balloon, which is capable of expanding as the volume of solution in the dialysate transporting system increases.
  • the bladder is coupled into the sytem by means of a check valve 72 which, when the pressure in the system exceeds some threshold level, allows fluid to flow into the bladder, but prevents fluid from flowing back into the transporting system.
  • the check valve 72 could be of the same construc tion as the valve 210 of FIG. 2, or could be a spring loaded valve similar to that to be described in conjunction with FIG. 3.
  • the collector 70 is positioned near a volume detector switch 76 so that when the bladder of the collector fills with excess solution and expands to a certain volume, the bladder wall contacts a feeler arm 80 operating the switch 76 which then generates a signal to sound an alarm or turn off the motor 84, as desired.
  • the volume of solution in the dialysate transporting system 6 is monitored so that when the volume exceeds some predetermined value, the volume detector switch 76 is actuated to sound an alarm or turn off the pump motor 84.
  • the collector 70 could then be removed for disposal of the excess solution and then replaced in the dialysate transporting system for further operation of the kidney system.
  • the switch 76 may be any conven tional electrical switch having a pair of contacts which close when the feeler arm 80 is moved a certain dis tance to thereby generate the appropriate signal.
  • FIG. 3 One embodiment of the vacuum regulator 74 of FIG. 1 is shown in FIG. 3.
  • the regulator includes a reservoir 302 through which the dialysate solution is passed from the canister 46 to the dialyzer element 38 (FIG. 1).
  • An element 310 having a threaded bore is positioned at one end of the reservoir 302'for receiving a complementarily threaded screw 306.
  • Attached to the end of the screw is a coil spring 314 which carries a plug or ball 318 on its free end.
  • the ball 318 when the screw 306 is screwed into the element 310, the ball 318 is moved closer to an orifice 322 through which dialysate solution is received, and when the screw 306 is unscrewed from the element 310 the ball 318 is moved further from the orifice 322.
  • the ball 318 serves as a partial obstruction to the flow of fluid through the orifice 322 to thereby regulate the rate and pressure of such flow. If it is desired to decrease the rate of flow, then, of course, the ball 318 is moved closer to the orifice 322 and if it is desired to increase the flow, the ball 318 is moved further from the opening 322. Numerous other arrangements could be provided for controlling the rate of flow of the dialysate solution.
  • the pumps 14 and 52 are operated by a motor driven compression element 16.
  • the pumps may be arranged so that the compression element 16 alternately compresses and releases one pump casing and then compresses and releases the other pump casing to provide a counter-pulsating pumping action in the blood transporting system 2 and the dialysate transporting system 6.
  • the physical arrangement of the pumps 14 and 52 and the compression element 16 for such a configuration is best seen in composite FIG. 4 and composite FIG, 5 as will next be described.
  • the two pumps 14 and 52 are positioned side-by-side, with the compression element 16 disposed between the pumps.
  • a retaining plate 410 having an internal surface which conforms to the exterior surface of the casing of the pump 14, is positioned to one side of and in contact with the pump 14.
  • a similar retaining plate 414 is positioned to one side of the pump 52.
  • Shaping the retaining plate surfaces to conform to the casing wall surface shapes also serves to increase the pumping and suction pressures achieveable with the pumps (compared, for example, to simply compressing the pump casing between two flat plates). Because the pumping and suction pressure developed by the pumps of the type disclosed varies with the shape of the retaining plates used, pumping and suction pressure can, in part, be controlled by appropriate selection of the shape of the retaining plates. Control of the pumping and suction pressure can also be obtained by appropriate selection of easing wall thickness and material resilience, with the greater thickness and resilience generally giving rise to greater pumping and suction pressure and with lesser thickness and resilience giving rise to lesser pumping and suction pressure. The combination of retaining plate shape and easing wall thickness and resilience therefore provides a simple and yet effective way of controlling pumping and suc tion pressures developed by the disclosed artificial kidney system.
  • FIGS. 48 and 4C show pump 52 being compressed by the compression element 16 and pump 14 being compressed by the compression element 16 respectively.
  • the compression element 16 is actuated by the motor 84 shown in composite FIG. 5.
  • the motor by conventional linkage, causes the compression element 16 to alternately move the compress first one pump casing and then the other in a pendulum-like fashion. With the positioning of the pump casings as shown, a single compression element may be used to operate both pumps. This provides a simple, effective and compact pump configuration.
  • FIG. 6 and FIG. 7 An alternative pump configuration is shown in composite FIG. 6 and FIG. 7. With this configuration, the casings of the pumps 14 and 52 are compressed simultaneously and then released simultaneously by compression element 17. As shown in composite FIG. 6 and FIG. 7, the two pumps 14 and 52 are again positioned together, with the compression element 17 extending upward between the pumps.
  • the element 17 includes a stem 17b and a horizontal head portion 17a to form a structural tee.
  • the motor 84 again by conventional linkage, causes the compression element 17 to move between a compressing" position, in which the casings of the pumps 14 and 52 are both compressed by the element 17 (FIG. 6B), and a release position, in which the casings of the pumps are released (FIG. 6A).
  • FIG. 7 shows a top view of the pumps with the pump casings being compressed by the compression element 17.
  • FIG. 8 shows a full-cycle" pump for use in either or both the blood transporting system 2 (provided a double-needle cannula is employed) and the dialysate transporting system 6.
  • This pump includes two casings 802 and 804 positioned on either side ofa compression element 806.
  • Each casing is constructed similar to the pump shown in FIG. 2, each including an inlet and outlet and inlet and outlet valves.
  • the two casings are coupled in parallel into a fluid-carrying line 808, with the inlets of each casing coupled to portion 808:: of the line and the outlets coupled to portion 808]).
  • the compression element 806 operates to compress and release first one of the casings and then the other.
  • a hemodialyzer comprising a dialyzer element through which blood of a patient and dialysate solution are circulated to enable transfer of waste and water from the blood to the solution,
  • blood transporting means for transporting blood from the patient to the dialyzer element and from the dialyzer element back to the patient
  • said pump means coupled into said blood transporting means, said pump means including a flexible casing which, when alternately compressed and released, causes blood to flow in said blood transporting means,
  • dialysate transporting means for transporting dialy sate solution from the dialysate source to the dialyzer element and from the dialyzer element to the dialysate sink, second pump means coupled into said dialysate transporting means, said second pump means including a flexible casing which, when alternately compressed and released, causes dialysate solution to flow in the dialysate transporting means, and
  • dialysate source and sink include a canister coupled in the dialysate transporting means and through which dialysate solution flows, and
  • filter means disposed in the canister for collecting waste from the dialysate solution when the solution flows through the canister.
  • a hemodialyzer as defined in claim 2 comprising an accumulator means which includes a jacket, and
  • a hemodialyzer as defined in claim 3 further comprising a collector means which is coupled into said dialysate transporting means for receiving excess dialysate solution.
  • a hemodialyzer defined in claim 6 further including feeler means positioned to engage the collector bladder when the bladder fills to a predetermined volume, and switch means for generating a signal when the bladder engages said feeler means.
  • a hemodialyzer as defined in claim 5 wherein said accumulator means and collector means are interposed in that portion of the dialysate transporting means which carries dialysate solution from the canister to the dialyzer element, and wherein said second pump means is coupled into that portion of the dialysate transporting means which carries solution from the dialyzer element to the canister.
  • a hemodialyzer comprising a dialyzer element through which blood of a patient and dialysate solution are circulated to enable transfer of waste and water from the blood to the solution,
  • blood transporting means for transporting blood from the patient to the dialyzer element and from the dialzer element back to the patient
  • said pump means coupled into said blood transporting means, said pump means including a flexible casing which, when alternately compressed and released, causcs blood to flow in said blood transporting means,
  • dialysate transporting means for transporting dialysate solution from the dialysate source to the dialyzer element and from the dialyzer element to the dialysate sink, second pump means coupled into said dialysate transporting means, said second pump means including a flexible casing which, when alternately compressed and released, causes dialysate solution to flow in the dialysate transporting means,
  • a vacuum regulator means coupled in said dialysate transporting means, said regulator means including a reservoir having an orifice through which dialysate solution flows. and plug means positionable in fron of said orifice at adjustable distances therefrom to control the rate of flow of solution through the orifice.
  • a hemodialyzer comprising a dialyzer element through which blood of a patient and dialysate solution are circulated to enable transfer of waste and water from the blood to the solution,
  • blood transporting means for tranporting blood from the patient to the dialyzer element and from the dialyzer element back to the patient
  • said pump means coupled into said blood transporting means, said pump means including a flexible casing which, when alternately compressed and released, causes blood to flow in said blood transporting means,
  • dialysate transporting means for transporting dialysate solution from the dialysate source to the dialyzer element and from the dialyzer element to the dialysate sink, second pump means coupled into said dialysate transporting means, said second pump means including a flexible casing which, when alternately compressed and released, causes dialysate solution to flow in the dialysate transporting means,
  • each of said pump means includes an inlet and an outlet by which the casing is coupled into the respective transporting means, an inlet check valve for allowing fluid to flow thcrethrough into the casing, and an outlet check valve for allowing fluid to flow therethrough from the casing.
  • a hemodialyzer as defined in claim 12 wherein said casings are positioned side by side, and wherein said pump operating means includes a compression element disposed between the casings and moveablc alternately to a first position to compress the casing of said first pump means and to a second position to compress the casing of said second pump means thereby to alternately operate the first and second pump means.
  • a hcmodialyzcr as defined in claim 15 further comprising a first retaining plate, one surface of which is shaped to comform to one side of the casing of said first pump means, said plate being positioned so that said one surface contacts said one side of the casing to prevent deformation of the one side when the casing is compressed, and
  • a second retaining plate one surface of which is shaped to conform to one side of the casing of said second pump means, said second plate being positioned so that said one surface thereof contacts said one side of the casing of the second pump means to prevent deformation thereof when the casing of the second pump means is compressed.
  • a hemodialyzer as defined in claim 12 wherein said casings are positioned together, and wherein said pump operating means includes a compression element movable between a first position in which both casing are compressed by the element, and a second position, in which the casings are released by the element.
  • An artificial kidney system comprising a dialyzer element through which blood of a patient and dialysate solution are circulated to enable transfer of waste and water from the blood to the solution,
  • blood transporting means for transporting blood from the patient to the dialyzer element and from the dialyzer element back to the patient
  • first pump means coupled into said blood transporting means for causing blood to flow from the patient to the dialyzer element and from the dialyzer element back to the patient
  • dialysate transporting means for transporting dialysate solution from the dialysate source to the dialyzer element and from the dialyzer element to the dialysate sink,
  • second pump means coupled into that portion of the dialysate transporting means which transports dialysate solution from the dialyzer element to the dialysate sink for causing solution to flow from the dialyzer element to the dialysate sink and from the dialysate source to the dialyzer element,
  • said second pump means including a flexible casing which, when compressed, forces solution from the casing toward the dialysate sink and which, when released, withdraws solution from the dialyzer element into the casing,
  • an accumulator means coupled into the dialysate transporting means for receiving dialysate solution when said second pump means is compressed and for discharging dialysate solution when said second pump means is released, and
  • a collector means coupled into said dialysate transporting for receiving excess dialysate solution from the dialysate transporting means.
  • a system as in claim 18 further comprising a check valve disposed in said collector means for allowing the flow of solution from the dialysate transporting means to the collector means and for preventing the flow of solution from the collector means to the dialysate transporting means.
  • fceler means positioned so as to be engageable by the bladder when the bladder fills beyond some predetermined volume
  • said vacuum regulator means includes a reservoir having an orifice through which dialysate solution flows, and plug means having a diameter larger than the diameter of the orilice and positioned in front of the orifice at adjustable distances therefrom to control the rate of flow of solution through the orifice.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Public Health (AREA)
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  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
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  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • External Artificial Organs (AREA)
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US455179A 1974-03-27 1974-03-27 Portable artificial kidney system Expired - Lifetime US3902490A (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
US455179A US3902490A (en) 1974-03-27 1974-03-27 Portable artificial kidney system
CH344075A CH592455A5 (ru) 1974-03-27 1975-03-18
SE7503199A SE7503199L (ru) 1974-03-27 1975-03-20
GB12254/75A GB1510129A (en) 1974-03-27 1975-03-24 Portable artificial kidney system
FR7509352A FR2274803A1 (fr) 1974-03-27 1975-03-25 Rein artificiel portable
JP50035045A JPS50133697A (ru) 1974-03-27 1975-03-25
BE154808A BE827225A (fr) 1974-03-27 1975-03-26 Rein artificiel portable
IT21691/75A IT1034615B (it) 1974-03-27 1975-03-26 Sistema a rene artificiale di tipo portatile
CA223,140A CA1072883A (en) 1974-03-27 1975-03-26 Portable artificial kidney system
SU7502117221A SU581844A3 (ru) 1974-03-27 1975-03-26 Искусственна почка
DE19752513489 DE2513489A1 (de) 1974-03-27 1975-03-26 Tragbare kuenstliche niere

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US455179A US3902490A (en) 1974-03-27 1974-03-27 Portable artificial kidney system

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US3902490A true US3902490A (en) 1975-09-02

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JP (1) JPS50133697A (ru)
BE (1) BE827225A (ru)
CA (1) CA1072883A (ru)
CH (1) CH592455A5 (ru)
DE (1) DE2513489A1 (ru)
FR (1) FR2274803A1 (ru)
GB (1) GB1510129A (ru)
IT (1) IT1034615B (ru)
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DE2513489A1 (de) 1975-10-02
BE827225A (fr) 1975-07-16
FR2274803A1 (fr) 1976-01-09
JPS50133697A (ru) 1975-10-23
CH592455A5 (ru) 1977-10-31
GB1510129A (en) 1978-05-10
SU581844A3 (ru) 1977-11-25
SE7503199L (ru) 1975-09-29
IT1034615B (it) 1979-10-10
FR2274803B1 (ru) 1979-01-05
CA1072883A (en) 1980-03-04

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