US3881464A - Sampling device and method - Google Patents

Sampling device and method Download PDF

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Publication number
US3881464A
US3881464A US311817A US31181772A US3881464A US 3881464 A US3881464 A US 3881464A US 311817 A US311817 A US 311817A US 31181772 A US31181772 A US 31181772A US 3881464 A US3881464 A US 3881464A
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sample
bristles
brush
obtaining
solvent
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US311817A
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Max Moses Levene
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320012—Brushes

Definitions

  • the present invention provides a device for obtaining cell and tissue samples which comprises a generally conical brush, the bristles of which are soluble in a liquid that does not cause morphological damage to the samples.
  • the present invention provides a method of obtaining a sample suitable for both cytological and histological examination comprising contacting such a brush with a hollow viscus, for example the uterine cervix. to obtain the sample on the bristles.
  • the bristles may then be contacted with such a liquid, and the liquid containing the sample treated to prepare the sample in a form suitable for at least one of the examinations.
  • the precise shape and size of the brush will, of course. be determined by the degree of penetration and extent of contact required in a particular case.
  • a conical brush of the order of 2.5 to 4 cm height and 2 to 3 cm diameter at base, a large surface area can be contacted at the desired regions.
  • the bristles should normally be made of a material that can be sterilized by generally used techniques, as should any support needed for the bristles. It will also be apparent that the brush should be made of materials that are not harmful to the person being examined or to the samples themselves.
  • Suitable materials include cellulose-based materials, for example Courtauld Dicel Celafibre, which are spun cellulose acetate fibres. Such a brush is of soft but firm texture and is readily soluble in acetone.
  • the brush is preferably attached to a sterilizable handle from which it may be readily detached.
  • the handle is a straight rod or shaft of length about 12 to l8 cm, having at the end to which the brush is to be attached a gripper mechanism for detachably retaining the brush.
  • a generally disk-shaped support member of approximately the same diameter as the base of the brush and slightly concave toward the brush.
  • Any suitable gripper mechanism may be used, for example a spring-loaded chuck. This can be operated from the other end of the handle whereby contamination is prevented.
  • the brush may be a force fit in or on the handle.
  • a metal wire 1 comprising a pair of strands twisted together, acts as a support to bristles (indicated generally by the reference numeral 2), the construction being akin to that of a pipecleaner;
  • the bristles 2 comprise a region 3 of approximately constant diameter extending from one end of the wire 1 to a point about a third of the way along its length;
  • the second region of bristles 4 extends from this point to the other end and is flared outwardly from this point to form a frustocone the maximum diameter of which is about 5 times that of the bristles in the region 3.
  • Attached to the end of the wire carrying the widest bristles is a rod 5 which serves as a handle.
  • the rod 5 has at the attached end a gripper 6 in the form ofa chuck which is operated by a plunger 7 at the other end of the rod.
  • a generally saucer-like support 8 is positioned on the attached end of the rod with its concave side facing the bristles.
  • the device comprising the brush and the handle is sterilized.
  • the plunger 7 is depressed to open the gripper 6 over the wire 1 and the plunger 7 is then released.
  • the brush is then inserted into the cervix and rotated to obtain the sample.
  • the brush is then released from the gripper into a fixative solution.
  • the fixative solution is then shaken to cause enough cells to be shed from the bristles to enable cytologic preparations to be made for cytological diagnosis. if necessary or desired, the remaining tissue and any remaining cells can be removed from the brush by dissolving it in a suitable solvent to prepare samples for histological diagnosis.
  • a method of obtaining from the uterine cervix a sample that is suitable for both cytological and histological examination which comprises the steps of obtaining from the uterine cervix a sample which contains both tissue and cellular material by contacting said cervix with a generally conical brush having radially projecting bristles made of soft fibres having the firm sample-retaining texture of cellulose acetate. which bristles are soluble in a solvent that does not cause morphological damage to the sample when said bristles and sample are immersed in said solvent. but are insoluble in conventional fixatives for said cells and tissues, immersing the brush having the sample thereon in a fixative for said sample.

Abstract

A device for obtaining cell and tissue samples, for example for screening for cervical cancer, which comprises a generally conical brush with bristles soluble in a liquid that does not damage the tissues, and a method of using the device.

Description

I United States Patent 1191 1111 3,881,464 Levene 1 May 6, 1975 [54] SAMPLING DEVICE AND METHOD 2,955,591 10/1960 MacLean 128/2 B 3,032,236 5/1962 Lewis et a1... 128/269 X [761 Y 46 Cranky 3,352,299 11 1967 Sagir0g1u...... 128/2 B Gardens, Keflsmgmm L0nd0n 3,411,979 11/1968 Lewis, Jr....... 15/159 A x En land 3,503,089 3 1970 Coneway 15 160 I 3,512,518 5/1970 Mishkin et a1. 128/2 B [22] 1972 3,513,830 5/1970 Kalayjian 1211/2 w [21] Appl. No.: 311,817 3,613,644 10/1971 Willson et a1. 128/2 R 3,626,470 12/1971 Antonides et al.... 128/2 R 3,712,296 1/1973 Gradone 128/2 W [30] Foreign Application Priority Data 3,774,590 11/1973 McDonald..... l28/2 B Dec 9 971 United Kingdom n 5730 47 3,776,219 12/1973 BIOWfl 128/2 W X 52 us. (:1 128/2 B; 15/159 A; 123/2 w; Primary Y H 128/269 Attorney, Agent, or Fzrm-Bnsebms & Kruger [51] Int. Cl A6lb 10/00 581 Field of Search 128/2 B, 2 w, 2 R, 269, 1571 ABSTRACT 128/304; 15/145, 160, 159 A A device for obtaining cell and tissue samples, for example for screening for cervical cancer, which com- [56] References Cited prises a generally conical brush with bristles soluble in UNITED STATES PATENTS a liquid that does not damage the tissues, and a 2,514,665 7/1950 Myller 128/2 B method of the 2,839,049 6/1958 MacLean 128/2 B 3 Claims, 1 Drawing Figure SAMPLING DEVICE AND METHOD This invention relates to a process and device for collecting specimens for diagnostic purposes.
While there has been as yet little progress in developing a cure for various forms of cancer, in the sense of providing pharmaceutical treatment. advances have been made in surgical treatments which rely to a large extent for success on early diagnosis. One example is in uterine cervical cancer where progress has been made by instituting tests of the section of the population at most risk. It is hoped that in future all women will be examined at regular intervals in an attempt to attain early detection of presence of abnormal cells.
At present, between 3 percent and 5 percent of women initially subjected to cytological examination appear to have abnormal cells and have to be examined by histological methods before a firm diagnosis can be made. Many of those so examined are found not to show symptoms of cancer. Apart from the expense and labor involved, the apprehension naturally felt by those called back makes it desirable to avoid a second exarnination. The presently used methods of obtaining samples normally do not remove tissue, or sufficient tissue. from the cervix to enable a histological test to be carried out using the original sample. Further, the area of the cervix from which the sample is collected does not usually extend sufficiently to ensure that abnormal material is collected if it is indeed present.
It is an object of the present invention to provide a device and method whereby sufficient material can be collected at one time to enable both cytological and histological examination to be carried out if necessary.
Accordingly, the present invention provides a device for obtaining cell and tissue samples which comprises a generally conical brush, the bristles of which are soluble in a liquid that does not cause morphological damage to the samples.
Further, the present invention provides a method of obtaining a sample suitable for both cytological and histological examination comprising contacting such a brush with a hollow viscus, for example the uterine cervix. to obtain the sample on the bristles. The bristles may then be contacted with such a liquid, and the liquid containing the sample treated to prepare the sample in a form suitable for at least one of the examinations.
The precise shape and size of the brush will, of course. be determined by the degree of penetration and extent of contact required in a particular case. By the use of a conical brush. of the order of 2.5 to 4 cm height and 2 to 3 cm diameter at base, a large surface area can be contacted at the desired regions.
It will be apparent that the bristles should normally be made of a material that can be sterilized by generally used techniques, as should any support needed for the bristles. It will also be apparent that the brush should be made of materials that are not harmful to the person being examined or to the samples themselves.
Suitable materials include cellulose-based materials, for example Courtauld Dicel Celafibre, which are spun cellulose acetate fibres. Such a brush is of soft but firm texture and is readily soluble in acetone.
The brush is preferably attached to a sterilizable handle from which it may be readily detached. Conveniently, the handle is a straight rod or shaft of length about 12 to l8 cm, having at the end to which the brush is to be attached a gripper mechanism for detachably retaining the brush. At this end there is also preferably provided a generally disk-shaped support member of approximately the same diameter as the base of the brush and slightly concave toward the brush.
Any suitable gripper mechanism may be used, for example a spring-loaded chuck. This can be operated from the other end of the handle whereby contamination is prevented. Alternatively, the brush may be a force fit in or on the handle.
The invention will now be described by way of example only with reference to the accompanying drawing.
Referring to the drawing:
A metal wire 1, comprising a pair of strands twisted together, acts as a support to bristles (indicated generally by the reference numeral 2), the construction being akin to that of a pipecleaner; the bristles 2 comprise a region 3 of approximately constant diameter extending from one end of the wire 1 to a point about a third of the way along its length; the second region of bristles 4 extends from this point to the other end and is flared outwardly from this point to form a frustocone the maximum diameter of which is about 5 times that of the bristles in the region 3. Attached to the end of the wire carrying the widest bristles is a rod 5 which serves as a handle. The rod 5 has at the attached end a gripper 6 in the form ofa chuck which is operated by a plunger 7 at the other end of the rod. A generally saucer-like support 8 is positioned on the attached end of the rod with its concave side facing the bristles.
In use, the device comprising the brush and the handle is sterilized. the plunger 7 is depressed to open the gripper 6 over the wire 1 and the plunger 7 is then released. The brush is then inserted into the cervix and rotated to obtain the sample. The brush is then released from the gripper into a fixative solution. The fixative solution is then shaken to cause enough cells to be shed from the bristles to enable cytologic preparations to be made for cytological diagnosis. if necessary or desired, the remaining tissue and any remaining cells can be removed from the brush by dissolving it in a suitable solvent to prepare samples for histological diagnosis.
Suitable dimensions for the various parts are as follows:
wire I 3 cm in length; bristle region 3 1 cm in length and 0.5 cm
diameter;
2 cm in length increasing bristle region 4 in diameter from (1.5 to
I. A method of obtaining from the uterine cervix a sample that is suitable for both cytological and histological examination, which comprises the steps of obtaining from the uterine cervix a sample which contains both tissue and cellular material by contacting said cervix with a generally conical brush having radially projecting bristles made of soft fibres having the firm sample-retaining texture of cellulose acetate. which bristles are soluble in a solvent that does not cause morphological damage to the sample when said bristles and sample are immersed in said solvent. but are insoluble in conventional fixatives for said cells and tissues, immersing the brush having the sample thereon in a fixative for said sample. causing relative agitation between said ing a coaxial handle projecting from its larger end and soft radially projecting bristles of cellulose acetate which are soluble in a liquid that does not cause morphological damage to the sample when said bristles and sample are immersed in said liquid, the narrower end of said brush being surmounted by a portion of substantially constant diameter.

Claims (3)

1. A method of obtaining from the uterine cervix a sample that is suitable for both cytological and histological examination, which comprises the steps of obtaining from the uterine cervix a sample which contains both tissue and cellular material by contacting said cervix with a generally conical brush having radially projecting bristles made of soft fibres having the firm sample-retaining texture of cellulose acetate, which bristles are soluble in a solvent that does not cause morphological damage to the sample when said bristles and sample are immersed in said solvent, but are insoluble in conventional fixatives for said cells and tissues, immersing the brush having the sample thereon in a Fixative for said sample, causing relative agitation between said brush and fixative to remove cellular material therefrom for cytological examination, and subsequently dissolving said bristles in said solvent to prepare a sample suitable for histological examination.
2. A method as claimed in claim 1 in which said fibres are made of cellulose acetate.
3. A device for obtaining cell and tissue samples which comprises a generally frusto-conical brush having a coaxial handle projecting from its larger end and soft radially projecting bristles of cellulose acetate which are soluble in a liquid that does not cause morphological damage to the sample when said bristles and sample are immersed in said liquid, the narrower end of said brush being surmounted by a portion of substantially constant diameter.
US311817A 1971-12-09 1972-12-04 Sampling device and method Expired - Lifetime US3881464A (en)

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GB5730471A GB1408140A (en) 1971-12-09 1971-12-09 Sampling device

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Cited By (52)

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US4108162A (en) * 1975-12-28 1978-08-22 Kiyoshi Chikashige Twisted wire brush with threaded assembly for collecting cells
US4127113A (en) * 1977-12-15 1978-11-28 Pap Smear Center, Inc. Multiple smear brush
US4467816A (en) * 1978-03-23 1984-08-28 Battelle-Institut E.V. Device for collecting cell material
US4662381A (en) * 1982-11-02 1987-05-05 Yushihiko Inaba Method of collecting a sample of endometrium cells
US4700713A (en) * 1985-12-31 1987-10-20 Futura Nova B.V. Device for obtaining a smear sample from a body cavity
US4754764A (en) * 1987-03-20 1988-07-05 Medical Dynamics, Inc. Cervical cytology device
US4759376A (en) * 1984-05-29 1988-07-26 Nils Stormby Endocervical sampling brush and smear method
US4762133A (en) * 1987-03-20 1988-08-09 Medical Dynamics, Inc. Cervical cytology device
US4873992A (en) * 1987-03-20 1989-10-17 Medical Dynamics, Inc. Cervical cytology device
US5147288A (en) * 1988-04-25 1992-09-15 Ivalda S.P.A. Cotton swab with depth prevention mechanism
US5191899A (en) * 1991-12-12 1993-03-09 Baal Associates, Inc. Pap smear collection device with bristles oriented in a plane
US5253652A (en) * 1993-01-25 1993-10-19 Fast James I Cytologic sampling device for collecting cervical and vaginal cell specimens
US5422273A (en) * 1993-03-23 1995-06-06 Baal Medical Products, Inc. Cell collection apparatus
US5445164A (en) * 1993-05-11 1995-08-29 Gynetech, Inc. Cervical tissue sampling device
US5456265A (en) * 1993-09-28 1995-10-10 Yim; Duck S. Endocervical brush assembly and method for obtaining tissue samples
US5462063A (en) * 1993-02-25 1995-10-31 Futura Nova B.V. Cell collecting device
US5623941A (en) * 1988-05-10 1997-04-29 Nils Stormby Cervical sampling velour brush
US5713369A (en) * 1995-09-13 1998-02-03 Vance Products Inc. Uterine endometrial tissue sample brush
WO1999025251A1 (en) * 1997-11-14 1999-05-27 Harwill Industries (Pty.) Ltd. Medical spatula
WO2000041630A1 (en) * 1999-01-15 2000-07-20 Zwelling Aamot Marcy L Cervical cancer self-screening methods and apparatus
US6193674B1 (en) * 1998-12-02 2001-02-27 Mdz Beheer B.V. Brush suitable for taking a smear
US6346086B1 (en) 1998-04-23 2002-02-12 Cook Urological Inc. Endocervical and exocervical cell collection device
EP1203566A1 (en) * 2000-11-02 2002-05-08 VBW Vereinigte Blinden Werkstätten Bern Device for endo- and ectocervical sampling
WO2002080776A1 (en) 2001-04-05 2002-10-17 Ashwood Timber & Plastics Ltd Device for taking samples of ceels from the cervix uteri
US6500114B1 (en) 1993-11-23 2002-12-31 Dofi Technologies, Inc. Method of extracting biopsy cells from the breast
US6612996B2 (en) * 2000-06-23 2003-09-02 Donald Williams Cervical sampler for pap smears
AU770194B2 (en) * 1998-12-29 2004-02-12 Inverness Medical - Biostar Inc. Methods for providing liquid and solid components of a sample for use in assay methods
US20040236247A1 (en) * 2003-05-24 2004-11-25 Syed Rizvi Endocervical Curette
US6869804B1 (en) * 1998-04-28 2005-03-22 Enterix Pty Limited Sample collection method
US7087028B2 (en) 2000-02-24 2006-08-08 R&G Medical And Development Corp. Method and apparatus for sampling cervical tissue
US20070270713A1 (en) * 2006-05-19 2007-11-22 Ng Raymond C Mucous gathering for Pap smear testing
US20070270715A1 (en) * 2006-05-19 2007-11-22 Ng Raymond C Rotary device to gather mucous for testing
US20090240164A1 (en) * 2008-03-18 2009-09-24 Alexandra Jean Gillespie Device and Method for Collecting Tissue Samples
US20090306702A1 (en) * 2004-08-23 2009-12-10 Elina Miloslavski Device for the Removal of Thrombi
US8146284B2 (en) 2008-09-27 2012-04-03 Shane Patrick Smith Combination brush and jag with patch
US8152739B1 (en) 2007-09-19 2012-04-10 Christine A. McCully Adjustable dual-brush cervical cytology collection device
US20130172778A1 (en) * 2011-12-29 2013-07-04 Express Scripts, Inc. Methods and systems for medical home testing
USD701600S1 (en) 2011-03-30 2014-03-25 Steven B. Kauffman Ear swab
US8763298B2 (en) 2008-09-27 2014-07-01 Shane Smith Combination brush and jag
US8968213B2 (en) 2010-10-19 2015-03-03 United States Endoscopy Group, Inc. Cytology brush apparatus with improvements
US20170112477A1 (en) * 2015-10-21 2017-04-27 Boston Scientific Scimed, Inc. Tissue sample device and methods
US9750483B2 (en) 2013-06-26 2017-09-05 Boston Scientific Scimed, Inc. Cytology brush devices and methods of use
EP3217178A2 (en) 2010-11-12 2017-09-13 incellDX, Inc. Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
US9820722B1 (en) 2008-12-16 2017-11-21 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method
US9968247B2 (en) 2014-05-02 2018-05-15 United States Endoscopy, Inc. Cleaning device for an endoscopic device
US10092275B2 (en) 2011-01-05 2018-10-09 Copan Italia S.P.A. Process for realising a device for collecting and transferring samples for molecular biology
JP2019018043A (en) * 2013-02-01 2019-02-07 エヌビジョン メディカル コーポレーション Methods and devices for fallopian tube diagnostics
US10327741B2 (en) 2003-04-01 2019-06-25 Copan Italia S.P.A. Swab for collecting biological specimens
DE102018208769A1 (en) 2018-06-04 2019-12-05 Bernhard Rinderknecht Sampling device for gynecological examinations
US20210128858A1 (en) * 2019-11-01 2021-05-06 Iowa State University Research Foundation, Inc. Tracheo-bronchial sampling device
US11364020B2 (en) 2016-12-09 2022-06-21 Techmed Ventures, Llc Brush biopsy device, kit and method
US11517295B2 (en) 2013-02-01 2022-12-06 Boston Scientific Scimed, Inc. Methods and devices for fallopian tube diagnostics

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GB1503264A (en) * 1975-03-29 1978-03-08 Battelle Institut E V Swabs for and methods of taking cell smears for diagnostic examination
JPS5468089A (en) * 1977-11-09 1979-05-31 Asahi Optical Co Ltd Paratriptic cell diagnostic brush
JPS5886108U (en) * 1981-12-08 1983-06-11 富士写真光機株式会社 Scraping cytology brush
JPS61238201A (en) * 1985-04-15 1986-10-23 月星化成株式会社 Production of shoe outer sole
JPH0648269B2 (en) * 1987-05-26 1994-06-22 フトウラ ノバ ベ−． フア− Sampling device
GB2208603A (en) * 1987-07-03 1989-04-12 Richards Dr Peter William Cervical sampling device
DE4005266A1 (en) * 1990-02-20 1991-08-22 Geka Brush Georg Karl Gmbh Scraper head for collecting cytological smears - has foamed polymer elements forming bristles or bladed surface
CA2113088A1 (en) * 1991-07-17 1993-02-04 Henry Martin Stenning Pap smear sampling device

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Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4108162A (en) * 1975-12-28 1978-08-22 Kiyoshi Chikashige Twisted wire brush with threaded assembly for collecting cells
US4127113A (en) * 1977-12-15 1978-11-28 Pap Smear Center, Inc. Multiple smear brush
US4467816A (en) * 1978-03-23 1984-08-28 Battelle-Institut E.V. Device for collecting cell material
US4662381A (en) * 1982-11-02 1987-05-05 Yushihiko Inaba Method of collecting a sample of endometrium cells
US4759376A (en) * 1984-05-29 1988-07-26 Nils Stormby Endocervical sampling brush and smear method
US4700713A (en) * 1985-12-31 1987-10-20 Futura Nova B.V. Device for obtaining a smear sample from a body cavity
AU588461B2 (en) * 1985-12-31 1989-09-14 Futura Nova B.V. Device for obtaining a smear sample from a body cavity
US4754764A (en) * 1987-03-20 1988-07-05 Medical Dynamics, Inc. Cervical cytology device
US4762133A (en) * 1987-03-20 1988-08-09 Medical Dynamics, Inc. Cervical cytology device
EP0283272A2 (en) * 1987-03-20 1988-09-21 Medical Dynamics, Inc. Cervical cytology device
EP0283272A3 (en) * 1987-03-20 1989-02-22 Medical Dynamics, Inc. Cervical cytology device
US4873992A (en) * 1987-03-20 1989-10-17 Medical Dynamics, Inc. Cervical cytology device
US5147288A (en) * 1988-04-25 1992-09-15 Ivalda S.P.A. Cotton swab with depth prevention mechanism
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Also Published As

Publication number Publication date
DE2259582B2 (en) 1981-05-14
JPS5731905B2 (en) 1982-07-07
DE2259582C3 (en) 1982-01-21
DE2259582A1 (en) 1973-06-14
JPS4865792A (en) 1973-09-10
GB1408140A (en) 1975-10-01

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