US3513830A - Instrument for obtaining body cultures - Google Patents

Instrument for obtaining body cultures Download PDF

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US3513830A
US3513830A US3513830DA US3513830A US 3513830 A US3513830 A US 3513830A US 3513830D A US3513830D A US 3513830DA US 3513830 A US3513830 A US 3513830A
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tube
instrument
cap
body
culture
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Wayne C Kalayjian
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Wayne C Kalayjian
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069Tip not integral with tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/15Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/38Swabs having a stick-type handle, e.g. cotton tips

Description

May 26, 1970 w. c. KALAYJIAN INSTRUMENT FOR OBTAINING BODY CULTURES Filed Oct. 10, 1967 INVENTOR \UAYNE C. KALAGMN nited States Patent 3,513,830 INSTRUMENT FOR OBTAINING BODY CULTURES Wayne C. Kalayjian, 6050 Appian Way, Long Beach, Calif. 90803 Filed Oct. 10, 1967, Ser. No. 674,138 Int. Cl. A61b 10/00 US. Cl. 1282 Claims ABSTRACT OF THE DISCLOSURE An instrument is disclosed for obtaining uncontaminated cultures from interior body organs that are located such that they may be reached through various contaminate-laden body passages. The structure is housed in a sterile package and includes an elongate tube adapted to be inserted through the body passage so that one end is contiguous to the organ of interest. The interior of the tube is shielded by a friction-fitted cap that is attached to the tube. A culture-swab rod bearing an absorbent tip is telescopically received within the tube so that the tip can force the cap off the tube providing the tip access to the organ of interest. After the desired culture is obtained (by direct contact), the culture-swab rod is withdrawn back into the tube for shielded withdrawal through the contaminated passage. The tube and the cap are made of flexible plastic in the illustrative embodiment while the culture-swab rod comprises a tubular handle of styrene, for example, fitted with a wooden stick, bearing an absorbent tip.

BACKGROUND AND SUMMARY OF THE INVENTION A variety of body organs and body tissues are accessible to some degree through natural body passages. For example, nasal passages provide access to several internal tissue surfaces. Similarly, the female cervix affords access to the uterus and the mouth affords access to the pharynx, and the esophagus.

In the practice of medicine (veterinary as Well as other branches) it frequently becomes desirable to obtain a test sample or culture from various internal body surfaces or tissues which are accessible through a natural body passage. However, the environment may be very unsanitary, and frequently the access passage is somewhat contaminated. As a result, obtaining a reasonably-true sample or culture directly from the organ of interest is quite unlikely. Specifically, for example, the insertion of a bare culture-swab through a body passage to engage the tissue of interest is normally impractical because (in withdrawing the swab) the sample is contaminated while moving through the access passage. This consideration is particularly true in the practice of veterinary medicine wherein the environment may be totally unsanitary.

In the past, a number of structures have been proposed with the objective of obtaining cultures or test samples from internal body tissues through natural passages. However, to the best of applicants knowledge, such structures either have been ineffective or impractical to use. Therefore, a need has continued to exist for an economical, effective, and practical instrument for obtaining cultures in the manner considered above.

In general, the present invention is directed to a structure comprising an elongate tube having a friction-fitted cap at one end, which cap is mechanically attached to the tube so as to be loosely afiixed when removed from a position of sealing relationship with the tube. An elongate culture-swab rod is then telescopically fitted into the tube, and includes an absorbent tip that is contiguous to the closure or cap of the tube. In using the structure, the closed end of the tube is inserted through a body passage 3,513,830 Patented May 26, 1970 to lie contiguous to the tissue of interest. From that location, the culture-swab rod is pushed through the tube disengaging the cap therefrom and contacting the tissue of interest (to obtain the desired culture). Subsequently, the culture-swab rod is withdrawn back into the tube for shielded removal from the body passage. Thus, the desired sample or culture is obtained in a pure form, i.e., free from other body contaminants. The structure as described is provided in a sterile form housed in a sealed package.

BRIEF DESCRIPTION OF THE DRAWINGS In the drawing, which constitutes part of this specification, an exemplary embodiment demonstrating various objectives and features hereof is set forth; specifically:

FIG. 1 is a perspective view of an instrument constructed in accordance with the present invention;

FIG. 2 is a fragmentary, enlarged vertical section taken centrally through the structure of FIG. 1;

FIG. 3 is an enlarged fragmentary view of FIG. 2 illustrating one phase of operation for the structure; and

FIG. 4 is another enlarged fragmentary view similar to that of FIG. 3 illustrating another operating phase for the structure.

DESCRIPTION OF THE ILLUSTRATIVE EMBODIMENT As required, a detailed illustrative embodiment of the invention is disclosed herein. However, it is to be understood that this embodiment merely exemplifies the invention which may be embodied in many forms that are quite different from the illustrative embodiment. Therefore, specific structural and functional details disclosed herein are not to be interpreted as limiting, but rather merely as a basis for the claims defining the scope of the invention.

Referring initially to FIG. 1, there is shown an instrument 10 housed in a somewhat transparent package 12. The package may comprise an elongate sleeve of plastic film closed at its ends by seals 14 and 16. It is generally important that these seals hermetically close the package 12 so that environmental bacteria and other contaminants may not reach the instrument 10.

Considering the instrument in greater detail, an elongate tube 18 (FIG. 2) carries a friction-fitted cap 20 at its operating end 22. The cap 20 is of a somewhat conical exterior configuration afiording the desirable smooth surfaces characteristic of a probe. The rear of the cap 20 defines an annular channel 24 which matingly receives the end 22 of the tube 18. Furthermore, the rear of the cap 20 defines an indentation 26 affording an abutment surface for the absorbent tip 28 of a culture-swab rod 30.

The tip 28 may comprise cotton or the like and is fitted on the end of a stick 32 which is telescopically received in an elongate hollow rod 34. The rod 34 in combination with the stick 32 is of greater length than the tube 18 so that a section 36 of the rod 34 extends out of the tube 18 when the tip 28 abuts the indentation 26 on the positioned cap. An index mark 38 is provided on the rod 34 for use in cooperation with the external end 40 of the tube 18 to manifest the position of the tip 28 in relation to the operating end 22 of the tube 18. The external end section 36 of the rod 34 terminates in a flattened enlargement 42 which may be utilized as a handle and which also limits the depth to which the rod 30 may be forced through the tube 18.

Of course, the structure hereof may be variously manufactured of many different materials; however, in one exemplary embodiment, it has been found economical and practical to provide the tube 18 of semi-soft flexible plastic. In such an embodiment, the cap 20 is formed of a similar material and is affixed to the tube 18 by a retainer tab 44. Of course, the tube 18 may comprise simply a section of uniform extruded material while the cap 20 along with the tab 44 may be integrally formed in an injection mold.

The tab 44 is afiixed to the exterior of the tube 18 by a weld 46, accomplished by the application of heat and pressure. Somewhat in this regard, it has been found desirable to limit the length of the tab 44 to between /2 and 1 /2 inches, however, to maintain it above twice the length of the cap 20. That is, by providing the tab 44 within that range of length, good withdrawal characteristics have been accomplished. Of course, the crosssectional size of the tab is as small as reasonably possible commensurate with the required strength.

Again considering a particular embodiment hereof, it has been found desirable to employ a conventional swab stick 32 of the type that are mass-produced in a sterile form. This stick 32 is telescopically received in the hollow rod 34 which comprises a tube closed at the external end by the flattened enlargement 42. When the rod 34 is made of styrene, the mark 38 may be easily etched thereon suificiently to clearly show through the walls of the tube 18. A friction fit between the stick 32 and the rod 34 has been found completely adequate; however, if desired adhesives or other jointing materials and structures may be employed.

Subsequent to assembly, the structure as shown in FIG. 2 may be variously sterilized in a gaseous or liquid medium before or after it is placed in the package 12. Of course, various techniques as well known in the prior art may be employed for combined packaging and sterilizing procedures to accomplish the sterile package.

Subsequent to completing the article, as depicted in FIG. 1, it may be variously stored and transported preliminary to actual use. At the time when it is desired to actually employ the instrument, the seal 16 is broken and the instrument is withdrawn from the package 12. During removal from the package some care may be exercised to avoid contact with the instrument which might severely contaminate surfaces thereon. However, as long as the guard cap 20 is in place, the inside of the tube and the tip 28 remain sterile. Therefore, the user need not exercise great care in this regard.

Next, the cap 20 and the leading end 22 of the instrument is inserted through a body orifice into the passage affording access to the tissue from which a sample is to be obtained. In general, it is advisable to pass the instrument with the tab 44 in a downward position, easing the instrument through the body passage.

At a time when the cap 20 is determined to be contiguous to the tissue of interest, the external end 40 of the tube 18 is firmly held while the section 36 is forcibly urged into the tube 18. As a result, the tip 28 forcibly engages the indentation 26 above a bore 48, forcing the cap 20 from the tube 18 substantially as illustrated in FIG. 3. It is to be noted in this regard that as a result of the mating engagement between the channel 24 and the end 22 of the tube 18, both the interior and exterior circular surfaces of the tube end 22 have been preserved sterile in passing through the body passage.

Further insertion of the section 36 into the tube 18 moves the tip 28 (FIG. 4) into contact with a tissue surface 50 from which mucuous or other test-sample substance is taken. Subsequently, the section 36 (FIG. 2) is withdrawn in relation to the tube 18 drawing the tip 28 (FIG. 4) from the position shown back into the tube 18. Thus, the tip 28, bearing the desired test substance, is withdrawn to a shielded and sterile environment in which it may be withdrawn through the body passage for analysis. It is to be noted, that in removing the tube 18, the cap 20 simply trails suspended on the tab 44. The double-length tab 44 allows considerable lateral move ment by the cap 20, to thereby facilitate withdrawal of the structure through the body passage.

As will be readily apparent to those skilled in the art, the structure hereof affords an effective means of obtaining a test substance or culture from tissue inside a body. In general, the embodiment disclosed above is of approximately 24 inches length and was designed for use in horses, cows, and like domestic animals. However, it is to be understood that the basic structure hereof may be readily produced with size and design modifications for utilization in any body, including the human body.

Although the illustrative embodiment disclosed herein has been set forth in considerable detail, it is to be emphasized that such detail, along with the specific structure thereof shall not impose a limitation upon the scope hereof; rather, the matter shall be interpreted in accordance with the claims as set forth below.

What is claimed is: 1. An instrument for obtaining uncontaminated cultures from interior body tissue through contaminate-laden passages, comprising:

an elongate tube having an operating end for insertion through said passage to the location of said tissue;

cap means for shielding the operating end of said tube while passing through said passage said cap means including a cover, friction fitted to said operating end, and an elongate flexible tab afiixed between said cover and said elongate tube; and

a culture swab rod of greater length than said elongate tube, said rod being telescopically fitted in said tube in sliding relationship therewith, whereby to be forced toward said operating end of said tube to disengage said cap means therefrom, and to extend out of the operating end of said elongate tube, to engage said tissue, and subsequently returned therewith.

2. An instrument according to claim 1 wherein said elongate tube comprises a somewhat flexible, uniform size tube.

3. An instrument according to claim 1 wherein said closure comprises a friction cap defining an interior annular channel to matingly receive said operating end of said tube.

4. An instrument according to claim 1 wherein said tab comprises a flexible length of material affixed between said cap and said tube; wherein said elongate tube comprises a somewhat flexible, uniform size tube; and wherein said culture swab rod comprises an elongate tube, bearing an absorbent tip on one end thereof.

5. An instrument according to claim 1 wherein said tube and said closure comprise flexible plastic material and said culture swab rod is indexed to indicate position relative said tube.

References Cited UNITED STATES PATENTS 2,413,480 12/1946 Winter 128-263 2,854,978 10/1958 Millman et al 128-26 XR 2,922,423 1/ 1960 Rickard et al. 128-263 3,037,496 6/1962 Melges 128-2 3,154,080 10/1964 Rowan et a1. 128-349 3,160,327 12/ 1964 Porcelli.

3,282,114 11/1966 Pell 128-2 XR 3,394,699 7/1968 Koett 128-2 FOREIGN PATENTS 1,000,022 8/1965 Great Britain.

RICHARD A. GAUDET, Primary Examiner K. L. HOWELL, Assistant Examiner U.S. C1. X.R. 206-632; 128-269

US3513830A 1967-10-10 1967-10-10 Instrument for obtaining body cultures Expired - Lifetime US3513830A (en)

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Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3633758A (en) * 1970-01-09 1972-01-11 North American Instr Corp Catheter storage rack
US3643650A (en) * 1970-05-25 1972-02-22 Harvey A Elder Method and apparatus for obtaining bacteriological information
US3712296A (en) * 1970-12-08 1973-01-23 F Gradone Swab device for medical specimens
FR2187272A1 (en) * 1972-06-09 1974-01-18 Cabral Vital
US3815580A (en) * 1972-08-31 1974-06-11 C Oster Apparatus for and method of collecting and preserving cytologic samples
US3877464A (en) * 1972-06-07 1975-04-15 Andrew R Vermes Intra-uterine biopsy apparatus
US3881464A (en) * 1971-12-09 1975-05-06 Max Moses Levene Sampling device and method
US3961620A (en) * 1971-03-12 1976-06-08 Research Industries Corporation Cervical sampling apparatus
US4023559A (en) * 1975-01-28 1977-05-17 Smith & Nephew (Australia) Pty. Limited Sampling catheter device
US4136680A (en) * 1976-06-04 1979-01-30 Transmed Corp. Self-contained apparatus for collection and maintenance of medical specimen and methods of using same
US4223093A (en) * 1978-08-25 1980-09-16 Precision Dynamics Corporation Culture collection and transport device
US4262677A (en) * 1979-03-26 1981-04-21 Bader Robert F Culture sampling device and method
US4284446A (en) * 1979-03-26 1981-08-18 Bader Robert F Culture sampling device
US4283809A (en) * 1979-11-05 1981-08-18 Prost Claude D Swab holding tool
US4318414A (en) * 1977-05-09 1982-03-09 Ovutime, Inc. Probe for obtaining cervical mucus
US4325387A (en) * 1979-12-17 1982-04-20 American Home Products Corporation Sealing apparatus for intrauterine pressure catheter and the like
WO1983003047A1 (en) * 1982-03-01 1983-09-15 E & K Corp Method and apparatus for collecting and/or growing protected biological specimens
US4457313A (en) * 1982-04-23 1984-07-03 Continental Plastics Corporation Shield protector for artificial insemination and culture collection instruments
US4562847A (en) * 1982-02-18 1986-01-07 Claes Nydahl Instrument for obtaining samples from uterus of animals
US4586604A (en) * 1984-06-28 1986-05-06 Continental Plastic Corporation Culture collection instrument and sealed swab holder therefor
WO1988007873A1 (en) * 1987-04-16 1988-10-20 Peachtree Medical, Inc. Syringe sealing device and method
US4838851A (en) * 1986-11-26 1989-06-13 Shabo Alan L Applicator and package therefor
US4848167A (en) * 1988-04-26 1989-07-18 Battelle Memorial Institute Sampling apparatus
US4952204A (en) * 1988-08-10 1990-08-28 Gam-Med Packaging Corporation Dry handle swab assembly and unit
EP0479619A1 (en) * 1990-10-05 1992-04-08 Elizabeth Tinsou Houang Swab
US5129402A (en) * 1991-02-19 1992-07-14 Accu-Med Corporation Apparatus for collecting and/or growing protected biological specimens
US5256537A (en) * 1991-12-11 1993-10-26 Becton, Dickinson And Company Culturette safety sleeve
US5780305A (en) * 1996-10-15 1998-07-14 Chisum; William J. Method for using forensic sampler
US5848895A (en) * 1997-09-22 1998-12-15 Martin; Daniel H. Sleeve for dental instrument nozzle
US5996780A (en) * 1997-10-20 1999-12-07 Gurrera; Vivien K. Cosmetic apparatus
WO2002000121A1 (en) * 2000-06-28 2002-01-03 Fuchs Alexander Von Anti-slip protection device for a housing head for medical instruments
US6516947B1 (en) 2000-08-11 2003-02-11 Viridian Packaging Solutions, Llc Containers having a fracture recess for opening the containers
US6610005B1 (en) 1996-04-26 2003-08-26 Jun Tao Catheter system for implanting embryos
US20050076461A1 (en) * 2003-10-09 2005-04-14 Garry Tsaur Retractable application cover
WO2005044363A1 (en) * 2003-10-09 2005-05-19 Garry Tsaur Retractable applicator cover
US7022289B1 (en) * 2001-10-10 2006-04-04 The United States Of America As Represented By The Secretary Of The Army Chemical and biological sampling device and kit and method of use thereof
US8282612B1 (en) * 2008-03-07 2012-10-09 Denise H. Miller Methods and devices for intrauterine absorption
US20120265097A1 (en) * 2011-02-22 2012-10-18 Cook Medical Technologies Llc Total core biopsy device and method of use
US8968213B2 (en) 2010-10-19 2015-03-03 United States Endoscopy Group, Inc. Cytology brush apparatus with improvements
US9078786B1 (en) 2012-10-19 2015-07-14 Denise H. Miller Methods and devices for collecting body fluids
US20150366744A1 (en) * 2014-06-20 2015-12-24 Wakesha Rivers Scalp Scratching Assembly
US9968247B2 (en) 2014-05-02 2018-05-15 United States Endoscopy, Inc. Cleaning device for an endoscopic device

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2413480A (en) * 1944-04-07 1946-12-31 Sanitary Tampon Corp Tampon applicator
US2854978A (en) * 1956-07-24 1958-10-07 Ortho Pharma Corp Applicator
US2922423A (en) * 1956-05-10 1960-01-26 Kimberly Clark Co Tampon ejector
US3037496A (en) * 1959-08-03 1962-06-05 Frederick J Melges Fertility testing apparatus
US3154080A (en) * 1962-05-24 1964-10-27 Rowlax Lab Co Aseptic catheter and introducer
US3160327A (en) * 1961-01-23 1964-12-08 Polymold Plastics Inc Dispensing spout with rupturable breathing diaphragm and closure therefor
GB1000022A (en) * 1963-01-18 1965-08-04 Johnson & Johnson Swabs
US3282114A (en) * 1963-04-09 1966-11-01 Pell Rodney Lang Sampler
US3394699A (en) * 1965-07-22 1968-07-30 Panto Entpr Inc Instrument for obtaining a biopsy specimen

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2413480A (en) * 1944-04-07 1946-12-31 Sanitary Tampon Corp Tampon applicator
US2922423A (en) * 1956-05-10 1960-01-26 Kimberly Clark Co Tampon ejector
US2854978A (en) * 1956-07-24 1958-10-07 Ortho Pharma Corp Applicator
US3037496A (en) * 1959-08-03 1962-06-05 Frederick J Melges Fertility testing apparatus
US3160327A (en) * 1961-01-23 1964-12-08 Polymold Plastics Inc Dispensing spout with rupturable breathing diaphragm and closure therefor
US3154080A (en) * 1962-05-24 1964-10-27 Rowlax Lab Co Aseptic catheter and introducer
GB1000022A (en) * 1963-01-18 1965-08-04 Johnson & Johnson Swabs
US3282114A (en) * 1963-04-09 1966-11-01 Pell Rodney Lang Sampler
US3394699A (en) * 1965-07-22 1968-07-30 Panto Entpr Inc Instrument for obtaining a biopsy specimen

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3633758A (en) * 1970-01-09 1972-01-11 North American Instr Corp Catheter storage rack
US3643650A (en) * 1970-05-25 1972-02-22 Harvey A Elder Method and apparatus for obtaining bacteriological information
US3712296A (en) * 1970-12-08 1973-01-23 F Gradone Swab device for medical specimens
US3961620A (en) * 1971-03-12 1976-06-08 Research Industries Corporation Cervical sampling apparatus
US3881464A (en) * 1971-12-09 1975-05-06 Max Moses Levene Sampling device and method
US3877464A (en) * 1972-06-07 1975-04-15 Andrew R Vermes Intra-uterine biopsy apparatus
FR2187272A1 (en) * 1972-06-09 1974-01-18 Cabral Vital
US3815580A (en) * 1972-08-31 1974-06-11 C Oster Apparatus for and method of collecting and preserving cytologic samples
US4023559A (en) * 1975-01-28 1977-05-17 Smith & Nephew (Australia) Pty. Limited Sampling catheter device
US4136680A (en) * 1976-06-04 1979-01-30 Transmed Corp. Self-contained apparatus for collection and maintenance of medical specimen and methods of using same
US4318414A (en) * 1977-05-09 1982-03-09 Ovutime, Inc. Probe for obtaining cervical mucus
US4223093A (en) * 1978-08-25 1980-09-16 Precision Dynamics Corporation Culture collection and transport device
US4262677A (en) * 1979-03-26 1981-04-21 Bader Robert F Culture sampling device and method
US4284446A (en) * 1979-03-26 1981-08-18 Bader Robert F Culture sampling device
US4283809A (en) * 1979-11-05 1981-08-18 Prost Claude D Swab holding tool
US4325387A (en) * 1979-12-17 1982-04-20 American Home Products Corporation Sealing apparatus for intrauterine pressure catheter and the like
US4562847A (en) * 1982-02-18 1986-01-07 Claes Nydahl Instrument for obtaining samples from uterus of animals
WO1983003047A1 (en) * 1982-03-01 1983-09-15 E & K Corp Method and apparatus for collecting and/or growing protected biological specimens
US4485824A (en) * 1982-03-01 1984-12-04 E & K Corporation Method and apparatus for collecting and/or growing protected biological specimens
US4457313A (en) * 1982-04-23 1984-07-03 Continental Plastics Corporation Shield protector for artificial insemination and culture collection instruments
US4586604A (en) * 1984-06-28 1986-05-06 Continental Plastic Corporation Culture collection instrument and sealed swab holder therefor
US4838851A (en) * 1986-11-26 1989-06-13 Shabo Alan L Applicator and package therefor
WO1988007873A1 (en) * 1987-04-16 1988-10-20 Peachtree Medical, Inc. Syringe sealing device and method
US4795443A (en) * 1987-04-16 1989-01-03 Peachtree Medical, Inc. Syringe sealing device and method
US4848167A (en) * 1988-04-26 1989-07-18 Battelle Memorial Institute Sampling apparatus
US4952204A (en) * 1988-08-10 1990-08-28 Gam-Med Packaging Corporation Dry handle swab assembly and unit
EP0479619A1 (en) * 1990-10-05 1992-04-08 Elizabeth Tinsou Houang Swab
US5129402A (en) * 1991-02-19 1992-07-14 Accu-Med Corporation Apparatus for collecting and/or growing protected biological specimens
US5256537A (en) * 1991-12-11 1993-10-26 Becton, Dickinson And Company Culturette safety sleeve
US5425915A (en) * 1991-12-11 1995-06-20 Becton Dickinson And Company Culturette safety sleeve
US6610005B1 (en) 1996-04-26 2003-08-26 Jun Tao Catheter system for implanting embryos
US5780305A (en) * 1996-10-15 1998-07-14 Chisum; William J. Method for using forensic sampler
US5874045A (en) * 1996-10-15 1999-02-23 Chisum; William J. Forensic sampler
US5848895A (en) * 1997-09-22 1998-12-15 Martin; Daniel H. Sleeve for dental instrument nozzle
US5996780A (en) * 1997-10-20 1999-12-07 Gurrera; Vivien K. Cosmetic apparatus
US20080172087A1 (en) * 2000-06-28 2008-07-17 Alexander Von Fuchs Anti-slip protection device for a housing head of medical instruments
WO2002000121A1 (en) * 2000-06-28 2002-01-03 Fuchs Alexander Von Anti-slip protection device for a housing head for medical instruments
US6516947B1 (en) 2000-08-11 2003-02-11 Viridian Packaging Solutions, Llc Containers having a fracture recess for opening the containers
US7022289B1 (en) * 2001-10-10 2006-04-04 The United States Of America As Represented By The Secretary Of The Army Chemical and biological sampling device and kit and method of use thereof
US7393694B1 (en) * 2001-10-10 2008-07-01 The United States Of America As Represented By The Secretary Of The Army Chemical and biological sampling device and kit and method of use thereof
US20050076461A1 (en) * 2003-10-09 2005-04-14 Garry Tsaur Retractable application cover
WO2005044363A1 (en) * 2003-10-09 2005-05-19 Garry Tsaur Retractable applicator cover
US8282612B1 (en) * 2008-03-07 2012-10-09 Denise H. Miller Methods and devices for intrauterine absorption
US8968213B2 (en) 2010-10-19 2015-03-03 United States Endoscopy Group, Inc. Cytology brush apparatus with improvements
US20120265097A1 (en) * 2011-02-22 2012-10-18 Cook Medical Technologies Llc Total core biopsy device and method of use
US9282948B2 (en) * 2011-02-22 2016-03-15 Cook Medical Technologies Llc Total core biopsy device and method of use
US9078786B1 (en) 2012-10-19 2015-07-14 Denise H. Miller Methods and devices for collecting body fluids
US9730840B2 (en) 2012-10-19 2017-08-15 Denise H. Miller Methods and devices for collecting body fluids
US9968247B2 (en) 2014-05-02 2018-05-15 United States Endoscopy, Inc. Cleaning device for an endoscopic device
US20150366744A1 (en) * 2014-06-20 2015-12-24 Wakesha Rivers Scalp Scratching Assembly

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