US3872614A - Rack for diagnostic diffusion plates - Google Patents

Rack for diagnostic diffusion plates Download PDF

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Publication number
US3872614A
US3872614A US437076A US43707674A US3872614A US 3872614 A US3872614 A US 3872614A US 437076 A US437076 A US 437076A US 43707674 A US43707674 A US 43707674A US 3872614 A US3872614 A US 3872614A
Authority
US
United States
Prior art keywords
rack
base
edges
compartments
ribs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US437076A
Other languages
English (en)
Inventor
Lamont J Seitz
Stephen G Hauser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU60715/73A priority Critical patent/AU484052B2/en
Priority to NL7313255A priority patent/NL7313255A/xx
Priority to CA182,029A priority patent/CA982088A/en
Priority to GB4545473A priority patent/GB1395665A/en
Priority to DE19732349875 priority patent/DE2349875A1/de
Priority to BE136498A priority patent/BE805866A/xx
Priority to CH1450773A priority patent/CH587917A5/xx
Priority to FR7336299A priority patent/FR2202672A1/fr
Application filed by Individual filed Critical Individual
Priority to US437076A priority patent/US3872614A/en
Application granted granted Critical
Publication of US3872614A publication Critical patent/US3872614A/en
Assigned to COOPER LABORATORES, INC. reassignment COOPER LABORATORES, INC. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: BAXTER TRAVENOL LABORATORIES, INC., A CORP. OF DE
Assigned to TECHNICON INSTRUMENTS CORPORATION, 511 BENEDICT AVENUE, TARRYTOWN, NEW YORK 10591-6097, A CORP. OF DE. reassignment TECHNICON INSTRUMENTS CORPORATION, 511 BENEDICT AVENUE, TARRYTOWN, NEW YORK 10591-6097, A CORP. OF DE. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: COOPER LABORATORIES, INC.,
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip

Definitions

  • a plate is slid in over the bottom from the side remote from the side l l References Clted wall and is held in position by the blocks.
  • the end and UNITED STATES PATENTS side walls depend from the bottom and ribs depend 2,944,356 7/1960
  • Anthon 40/1061 from the bottom both sides to add Strength and 3,110,120 11/1963 Dunner H 40/79 gidity to the rack.
  • the underside of the bottom is pro- 3.197.888 8/i965 Held 40/64 A X vided with a plurality and preferably twelve pairs of 3. 8. 36 68 M achlan 40/1061 spaced projections which engage a screw in a viewer FOREIGN PATENTS 0R APPLICATIONS to shift the rack laterally for insepction purposes.
  • the present invention relates to a rack for diagnostic diffusion plates and is concerned primarily with such a rack that may be disposable and which accepts a plurality of said plates whereby their handling and manipulation is facilitated.
  • diffusion plates are widely used for diagnostic purposes. Such plates are quite small and are handled with great difficulty and inconvenience. They are of rectangular form with the longer sides frequently having thin external flanges. They are adapted to hold an agar gel material and a diagnostic reagent in which are formed a plurality of wells or recesses in alignment. In use, they are generally placed in an incubator for a prescribed period of time and subsequently inspected to determine the extent or degree of discoloration or diffusion which radiates from each well. The latter operation is carried out with a viewer which desirably would include means for shifting a plate laterally to aid in measuring the extent of radial discolor ation.
  • racks have been proposed heretofor for diagnostic diffusion plates, it is believed that the known art is singularly lacking in a rack which may be produced at a cost so low as to permit of disposal and convenient replacement, is made of injection molded plastic, is of a simple rigid construction, will readily accept a plurality of diffusion plates with a simple operation, and includes a device which cooperates with complemental mechanism in a veiwer to laterally shift the rack.
  • a rack of injection molded plastic comprising a rectangular bottom having a plurality of rectangular openings therein, a side wall and end walls integral with the bot tom.
  • a pair of plate holding blocks are carried by the bottom midway the sides of each opening and spaced from the edges thereof. Another pair of these blocks optionally can be located in spaced relation to the corner of each opening at the end thereof adjacent the side Wall.
  • blocks are provided which abut each opening and in effect define a stall or compartment into which a plate may be slid from the side remote from the side wall.
  • Ribs upstand from the bottom at the entry side of the compartments and cooperate with the blocks in defining the stalls.
  • the side and end walls extend below the bottom and together with depending ribs along the sides of the bottom lend strength and rigidity to the structure.
  • a plurality of channel elements each having an inwardly extending projection that engages the thread of a screw stem of a lateral shifting device of a viewer.
  • FIG. 1 is a top plan view of a rack for diagnostic diffusion plates embodying the precepts of this invention
  • FIG. 2 is a longitudinal vertical section of the rack of FIG. 1 being taken on the plane of the line 2-2 of FIG.
  • FIG. 3 is a transverse vertical section through the rack being taken on the plane of the line 33 of FIG.
  • FIG. 4 is a detailed section on an enlarged scale through one of the plate holding blocks, being taken on the plane of the line 4-4 of FIG. 1;
  • FIG. 5 is a detailed perspective depicting a block and a portion of the bottom in assembled relation
  • FIG. 6 is a bottom plan view of the rack
  • FIG. 7 is a detail on an enlarged scale looking at one of the channel elements from the bottom;
  • FIG. 8 is a detailed section taken on the plane of the line 88 of FIG. 7 with a portion of the screw stem of a viewer shown in broken lines;
  • FIG. 9 is a detail taken on the plane of line 99 of FIG. 8 depicting the screw stem in section.
  • a rack embodying the principles of the present invention is designated generally at 10. It is made of injection molded plastic and includes, as a characteristic and essential element, a bottom 11 of rectangular shape presenting side edges 12 and 13 and end edges 14 and 15. Bottom 11 is formed with a plurality of rectangular openings 16, I7, 18, 19, each of which defines a compartment.
  • the number of openings disclosed is not to be taken as a limitation on the invention as the number may be varied without departing from the spirit and scope of the invention.
  • each opening 16, 17, 18, and 19 has side edges 20 and 21 and end edges 22 and 23.
  • Each set of side edges 20 and 21 define a transverse panel 24.
  • an end wall Integral with bottom 11 and end edge 14 is an end wall comprising an upstanding portion 25 (FIGS. 1 and 2) and a depending portion 26 (FIGS. 2 and 6). Likewise, an end wall is integral with bottom 11 at end edge 15 and includes an upstanding portion 27 (FIGS. 1 and 2) and a depending portion 28 at each side.
  • Integral with side edge 12 is an upstanding side wall 29. Integral with the upper edge of end wall portion 27 is a panel 30 from which depends an end flange 31 (FIG. 2). Ribs 32 also depend from panel 30 at each side as shown in FIG. 6. Panel 30 may carry any suitable indicia for display purposes.
  • a block 34 Carried by the inner face of end wall portion and midway its ends is a block 34 (FIG. 2), the lower edge of which is spaced from bottom 11, as indicated at 35. This space is dimensioned to accurately receive the external longitudinal flange of a diffusion plate.
  • Another block 36 (FIG. 1) is similarly mounted on end wall portion 25 at its end adjacent to side wall 29.
  • a vertical flange 37 which carries on one race a block 38 spaced from bottm 11 as above described and another block 39 on its opposite face.
  • a so-called double block 40 Mounted on the panel 24 which defines one side of opening 16 is a so-called double block 40.
  • One of these blocks is depicted in detail in FIGS. 4 and 5. It comprises a head 41 and a web-like shank 42 which are separated by shoulders 43.
  • Panel 24 is formed wit a pair of slots 44 which are present as an incident to molding block 40 integrally with panel 24.
  • Male and female mold parts are employed in forming each block 40 integral with a panel 24 and having shoulders 43. The male elements of the mold are withdrawn through slots 44.
  • the shoulders 43 are spaced from panel 24 a distance corresponding to the thick ness of a diffusion plate flange as above described.
  • bottom 11 is formed with an upstanding rib 45 which cooperates with the end of wall portion 25 in marking off a point of entry for a diffusion plate.
  • a plate may be slid past this point of entry into the compartment defined by blocks 34, 36, 38, and 40. The plate is slid inwardly until its end edge abuts side wall 29. Thus the plate is accurately positioned and secured in this position by the blocks.
  • each block 40 provides a shoulder 43 for each compartment 16, 17, 18, and 19.
  • Side wall 29 also has additional flanges corresponding to flange 37 with blocks corresponding to blocks 38 and 39 on its opposite faces.
  • end wall portion 27 carrying a block corresponding to block 34 each of the remaining openings 17, 18, and 19 is provided with a compartment for receiving a plate in the manner above described.
  • bottom 11 has integrally formed on its underside a plurality of ribs 46 which are spaced along marginal portions of bottom 11 to lend strength and rigidity to the rack. These ribs also serve to maintain axial alignment of the rack when the rack is used in cooperation with screw stem 49 as will be described below.
  • channel element 47 Depending from the underside of bottom 11 at the end of each panel 24 adjacent to side wall 29 is a channel element 47.
  • channel element 47 is formed with a projection 48 any of which extends into the threads of a screw stem 49. The latter is included in apparatus which is used in viewing a plate after incubation for the purpose of shifting the rack laterally.
  • a plurality of diagnostic diffusion plates are first prepared in the conventional manner.
  • a preferred diffusion plate is one such as described in co-pending application Ser. No. 99,797, filed Dec. 21, 1971.
  • a plate is then inserted in the compartment for each opening l6, l7, l8, and 19.
  • the plates are accurately positioned in the rack and held in these positions with the longitudinal flanges of the plates fitting in the spaces beneath blocks 34, 36, 38, and 40.
  • the rack is now placed in an incubator for a predetermined period of time. After incubation, it is introduced to viewing apparatus which includes a screw stem 49. As this is accomplished, a projection 48 engages the threads of the stem to allow translation, and ribs 46 and channel elements 47 straddle the stem to maintain axial alignment of the rack. The stem may now be rotated to shift the rack laterally and thus enable the viewer to determine the extent of radial discoloration or diffusion about any well in the plate.
  • each of compartments l6, 17, 18 and 19 has three pairs of projections 48 adjacent to panels 24 or 30 on the under side of bottom 11.
  • the rack is thereby adapted to ac comodate two embodiments of the diffusion plates disclosed in said co-pending application Ser. No. 99,797.
  • the diffusion plate contains one centrally located recess having a row of diffusion wells aligned in the gel whereas in another embodiment (FIGS. 6 to 10) the diffusion plate contains two parallel recesses, each having a row of such diffusion wells.
  • there are three possible rows of well diameters which are desired to be read in said two diffusion plate embodiments.
  • the three pairs of projections 48 in the rack ofthe present invention allow for placement of the rack on the screw stem 49 in three positions, each corresponding to one of said rows of well diameters.
  • a diffusion plate having one recess centrally disposed therein the central pair of projections 48 at each panel 24 or 30 will engage the screw stem 49; whereas with a diffusion plate having two parallel recesses the two outer pairs of projections 48 will be used for engaging the screw stem 48, one pair being used for each recess.
  • the rack is adapted to reading two axes by translating motion of the screw stem 49.
  • An elongated horizontal rib 50 which extends the width of the rack can be provided for that purpose.
  • One or two diffusion plates can then be placed vertically in the rack, one on either side of blocks 40 and positioned lengthwise between end wall 25 and rib 50 for reading diameters parallel thereto. It is thereby possible in operation to read two diameters of the diffusion rings, first by reading one diameter with the plate positioned horizontally as described herein before and then by reading another diameter with the plate positioned vertically. This permits greater accuracy in determining diffusion ring sizes in cases in which the diffusion rings are somewhat oblong instead of true circular. Appropriate calculations for estimating the area of the diffusion ring can then be made by known mathematical formulae.
  • a disposable rigid plastic rack for receiving a plurality of diagnostic diffusion plates, each having external longitudinal flanges, said rack comprising:
  • each said block adjacent each opening cooperating with said base to define a compartment adapted to receive one of the plates, each of said compartments having an entry for a plate at the side remote from said side wall;
  • integral rib upstanding from said base and which includes one of said plate positioning blocks between the side edges of two adjacent said compartments one of said adjacent compartments being an end compartment; said rib being substantially par- 6 allel to the side edges of said compartments and extending substantially the full length of said side edges; said rib cooperating with said plate positioning blocks to receive two of said plates in side-byside relationship transverse to the side edges of said compartments;
  • each opening is partially defined by transverse panels and certain of said blocks which are located substantially midway the side edges of the openings take the form of double blocks upstanding from said panels.
  • each double block comprises a head and a shank separated by a pair of shoulders on opposite sides of the head, and the shank is secured to a panel with the shoulders spaced therefrom.
  • each channel on one side of said rack is provided with an oblique, downwardly depending projection at the outer edge of, and

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
US437076A 1972-10-12 1974-01-28 Rack for diagnostic diffusion plates Expired - Lifetime US3872614A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU60715/73A AU484052B2 (en) 1972-10-12 1973-09-26 Rack for diagnostic diffusion plates
NL7313255A NL7313255A (de) 1972-10-12 1973-09-26
CA182,029A CA982088A (en) 1972-10-12 1973-09-27 Rack for diagnostic diffusion plates
GB4545473A GB1395665A (en) 1972-10-12 1973-09-28 Rack for diagnostic diffusion plates
DE19732349875 DE2349875A1 (de) 1972-10-12 1973-10-04 Traeger fuer eine anzahl diagnostischer diffusionsplatten
BE136498A BE805866A (fr) 1972-10-12 1973-10-10 Support pour plaques de diffusion pour diagnostics
CH1450773A CH587917A5 (de) 1972-10-12 1973-10-11
FR7336299A FR2202672A1 (de) 1972-10-12 1973-10-11
US437076A US3872614A (en) 1972-10-12 1974-01-28 Rack for diagnostic diffusion plates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29711472A 1972-10-12 1972-10-12
US437076A US3872614A (en) 1972-10-12 1974-01-28 Rack for diagnostic diffusion plates

Publications (1)

Publication Number Publication Date
US3872614A true US3872614A (en) 1975-03-25

Family

ID=26969992

Family Applications (1)

Application Number Title Priority Date Filing Date
US437076A Expired - Lifetime US3872614A (en) 1972-10-12 1974-01-28 Rack for diagnostic diffusion plates

Country Status (8)

Country Link
US (1) US3872614A (de)
BE (1) BE805866A (de)
CA (1) CA982088A (de)
CH (1) CH587917A5 (de)
DE (1) DE2349875A1 (de)
FR (1) FR2202672A1 (de)
GB (1) GB1395665A (de)
NL (1) NL7313255A (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329997A1 (fr) * 1975-11-03 1977-05-27 Int Diagnostic Tech Porte-reactif pour diagnostic et bati pour son examen visuel
US4381706A (en) * 1981-03-18 1983-05-03 Harpold Charles W Printing screen and method
US4565290A (en) * 1984-05-14 1986-01-21 Armstrong World Industries, Inc. Display rack

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112844510A (zh) * 2020-12-30 2021-05-28 西安市红会医院 病理诊断工作台

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944356A (en) * 1956-03-19 1960-07-12 Borwin F Anthon Transparency equipment
US3110120A (en) * 1960-09-28 1963-11-12 Argus Inc Reversible slide magazine drive
US3197888A (en) * 1962-09-04 1965-08-03 Richard A Held Method for teaching manual skills
US3398636A (en) * 1965-12-27 1968-08-27 Display Corp Of America Projector table for overhead projector

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944356A (en) * 1956-03-19 1960-07-12 Borwin F Anthon Transparency equipment
US3110120A (en) * 1960-09-28 1963-11-12 Argus Inc Reversible slide magazine drive
US3197888A (en) * 1962-09-04 1965-08-03 Richard A Held Method for teaching manual skills
US3398636A (en) * 1965-12-27 1968-08-27 Display Corp Of America Projector table for overhead projector

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329997A1 (fr) * 1975-11-03 1977-05-27 Int Diagnostic Tech Porte-reactif pour diagnostic et bati pour son examen visuel
US4381706A (en) * 1981-03-18 1983-05-03 Harpold Charles W Printing screen and method
US4565290A (en) * 1984-05-14 1986-01-21 Armstrong World Industries, Inc. Display rack

Also Published As

Publication number Publication date
GB1395665A (en) 1975-05-29
FR2202672A1 (de) 1974-05-10
BE805866A (fr) 1974-02-01
DE2349875A1 (de) 1974-04-18
NL7313255A (de) 1974-04-16
AU6071573A (en) 1975-03-27
CA982088A (en) 1976-01-20
CH587917A5 (de) 1977-05-13

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Legal Events

Date Code Title Description
AS Assignment

Owner name: COOPER LABORATORES, INC., 3145 PORTER DRIVE, PALO

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:BAXTER TRAVENOL LABORATORIES, INC., A CORP. OF DE;REEL/FRAME:004067/0785

Effective date: 19820917

AS Assignment

Owner name: TECHNICON INSTRUMENTS CORPORATION, 511 BENEDICT AV

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:COOPER LABORATORIES, INC.,;REEL/FRAME:004926/0396

Effective date: 19880628