US3864089A - Multiple-sample rotor assembly for blood fraction preparation - Google Patents

Multiple-sample rotor assembly for blood fraction preparation Download PDF

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Publication number
US3864089A
US3864089A US423381A US42338173A US3864089A US 3864089 A US3864089 A US 3864089A US 423381 A US423381 A US 423381A US 42338173 A US42338173 A US 42338173A US 3864089 A US3864089 A US 3864089A
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US
United States
Prior art keywords
sample
chambers
rotor portion
passageways
rotor assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US423381A
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English (en)
Inventor
Thomas O Tiffany
James C Mailen
Wayne F Johnson
Charles D Scott
Jr W Wilson Pitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Atomic Energy Commission (AEC)
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US Atomic Energy Commission (AEC)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Atomic Energy Commission (AEC) filed Critical US Atomic Energy Commission (AEC)
Priority to US423381A priority Critical patent/US3864089A/en
Priority to BE151033A priority patent/BE822803A/xx
Priority to ES432554A priority patent/ES432554A1/es
Priority to FR7439884A priority patent/FR2254027A1/fr
Priority to NL7415917A priority patent/NL7415917A/xx
Priority to AT981474A priority patent/ATA981474A/de
Priority to GB5317474A priority patent/GB1451859A/en
Priority to NO744440A priority patent/NO744440L/no
Priority to JP49141222A priority patent/JPS50114293A/ja
Priority to IT83642/74A priority patent/IT1028560B/it
Priority to DK641374A priority patent/DK641374A/da
Priority to SE7415499A priority patent/SE7415499L/
Priority to DE19742458384 priority patent/DE2458384A1/de
Priority to AU76283/74A priority patent/AU483685B2/en
Priority to IL46233A priority patent/IL46233A0/xx
Application granted granted Critical
Publication of US3864089A publication Critical patent/US3864089A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes

Definitions

  • Liquids for washing and hemolyzing the cell fractions are introduced to the chambers following recovery of the plasma fraction by means of a central dynamic distribution port and a multiplicity of distribution passageways extending between the dynamic distribution port and the centrifugal ends of respective chambers. Unloading of blood fractions and washing liquid is accomplished through transfer passageways extending from a point intermediate the centrifugal and centripetal ends of the chambers radially inward and then outward to the periphery of the inner disk-shaped rotor assembly portion.
  • a removable outer rotor portion defining at least one collection chamber for receiving materials discharged from the transfer passageways is nested concentrically about the inner rotor assembly portion.
  • the invention described herein relates generally to blood fraction preparation systems and more particularly to an improved multi-sample rotor assembly suitable for separating blood into plasma and cell fractions, washing and hemolyzing the cell fraction, and for separately recovering the plasma, hemolysate, and washed cells. It was made in the course of, or under, a contract with the U.S. Atomic Energy Commission.
  • Another, more particular object of the invention is to provide a rotor assembly suitable for separating a multiplicity of blood samples into plasma and cell fractions, washing and hemolyzing the cell fractions, and separately recovering the plasma, hemolysate, and washed cells.
  • a rotor assembly for preparing blood fractions from a multiplicity of whole blood samples.
  • the rotor assembly includes an inner rotor portion defining a circular array of radially extending whole blood sample-receiving chambers.
  • Static loading ports communicate between the top end surface of the inner rotor portion and respective chambers in the circular array of chambers to facilitate the static loading of whole blood samples therein.
  • a central dynamic distribution port communicates, by way of a multiplicity of radially extending distribution passageways, with the centrifugal ends of each of the sample receiving chambers.
  • Transfer passageways for unloading of blood fractions and washing liquid from the chambers extend from a point intermediate the centrifugal and centripetal ends of the chambers radially inward and then outward to the periphery of the inner rotor portion.
  • a removable outer rotor portion, defining at least one collection chamber for receiving materials discharged from the transfer passageways, is nested concentrically about the inner rotor portion.
  • Rotor assemblies made in accordance with the invention are suitable for separating blood into plasma and cell fractions, washing and hemolyzing the cell fraction, and for separately recovering the plasma, hemolysate, and washed cells.
  • FIG. 1 is a perspective view, vertically sectioned, showing a rotor assembly made in accordance with the invention mounted within a turntable.
  • FIG. 2 is a top plan view, partially cut away, of the rotor assembly of FIG. 1.
  • FIG. 3 is a perspective view of a removable outer rotor portion designed for collecting cell fraction wash liquid.
  • FIG. 4 is a perspective view of a removable outer rotor portion defining an array of sample analysis cuvettes suitable for use with the invention and in a fast analyzer of the rotary cuvette type.
  • FIG. 1 a rotor assembly made in accordance with the invention is shown nested within a motor driven turntable 1.
  • turntable 1 is provided with passageways 2 extending from the turntable axis to several points about its periphery. Passageways 2 communicate with a suitable vacuum source for reasons explained below in connection with operation of the subject rotor assembly.
  • the rotor assembly includes an inner disk-shaped rotor portion 3 defining a circular array (only one shown in FIG. 1) of whole blood sample-receiving chambers 4.
  • Static loading ports 5, extending through the top surface of disk-shaped rotor portion 3, facilitate the direct loading of individual whole blood samples into respective sample-receiving chambers 4 under static conditions.
  • Ports 5 are disposed near the centripetal ends of chambers 4 to avoid overflow of chamber contents through the ports during rotation.
  • Other liquids such as washing or hemolyzing liquids may be dynamically distributed to the entire array of chambers 4 by means of a central dynamic distribution port 6 and a multiplicity of distribution passageways 7 communicating between that port and the centrifugal ends of respective chambers 4.
  • Distribution passageways 7 intersect at the periphery of dynamic distribution port 6 to create a saw-tooth or serrated-edge effect which provides a substantially equal distribution of liquid into passageways 7 when the rotor assembly is rotating and liquid is injected into port 6.
  • Transfer passageways 8 extend from a radially intermediate point along the bottom of each chamber 4, radially inward, upward, and then radially outward to the periphery of inner diskshaped rotor portion 3.
  • FIG. 3 is cut away to illustrate a passageway 8.
  • a removable outer rotor portion 9 Nested concentrically about inner disk-shaped rotor portion 3 is a removable outer rotor portion 9 defining a plurality of collection chambers 10 for receiving liquids discharged from respective sample-receiving chambers 4. As shown, chambers 10 open in register with the radial extremities of respective passageways 8. Vents 11 extend radially inward and upward from each collection chamber 10 to the top surface of rotor portion 9.
  • a vacuum annulus 12 is formed above outer rotor portion 9 and the adjoining area of inner rotor portion 3 by means of an annular sealing disk 13 positioned between upstanding rim 14 of turntable 1 and a raised flange formed on the top surface of inner rotor portion 3.
  • O-rings 16 provide the necessary vacuum seal while permitting removal of disk 13 for replacement of outer rotor portion 9 or removal of the entire rotor assembly from the turntable. As shown, passageways 2 open at the side of annulus 12.
  • Rotor assemblies made in accordance with the invention are conveniently fabricated by machining cavities and channels into a central plastic disk 17 which is sandwiched between and attached, by cementing for example, to top and bottom cover disks l8 and 19, to form chambers and interconnecting channels.
  • sandwich construction is specifically illustrated with reference to the inner rotor portion 3, outer rotor portion 9 may be constructed in a like manner. All or part of the disks may conveniently be made of transparent plastic to facilitate the observation, using a strobe light for example, of the rotor contents.
  • F IG. 2 is a plan view of a rotor assembly identical to that illustrated in the perspective view of FIG. I.
  • a multiplicity of sample handling systems comprising sample-receiving chambers 4, associated passageways 7 and 8, and collection chambers 10 are contained in a single rotor assembly, thereby facilitating the simultaneous preparation of separate blood fractions from multiple samples. More or fewer than the eight sample handling systems illustrated may be provided in a single rotor depending on the size of the rotor and the respective chambers used therein.
  • FIG. 3 illustrates part of a removable outer rotor portion 9' designed for collecting cell fraction wash liquid.
  • a single annular collection chamber 10 is provided for collecting wash liquid from all of the sample handling systems in a rotor assembly.
  • a single annular opening 21 facilitates the discharge of wash liquid from the transfer passageways into collection chamber 10. Intermingling of wash liquid from the respective systems is permitted in chamber 10 since the wash liquid is discarded without additional analysis except as needed to determine the need, if any, for additional washing.
  • Vents 11 extend from chamber 10' to the top surface of rotor portion 9
  • FIG. 4 illustrates a removable outer rotor portion 9" defining an array of cuvettes I0" suitable for use in a fast photometric analyzer of the rotary cuvette type such as described in U.S.
  • ROTOR OPERATION Passageways 8 open within chambers 4 at a radially intermediate position which is calculated to be slightly centripetal to the blood cell-plasma interface for normal blood and specific sample volumes in order to remove most of the plasma fraction without disturbing the blood cell fraction.
  • the rotor is then stopped and the outer rotor portion 9 removed to permit recovery and testing of the respective plasma fractions.
  • outer rotor portion 9 is replaced with an outer rotor portion 9' such as that shown in FIG. 3 and the reassembled rotor rotated at about 2,000 rpm.
  • a selected volume of physiological saline wash solution is then injected into dynamic distribution port 6 causing it to pass in essentially equal volumes through passageways 7 to respective chambers 4 where it mixes with and washes the blood cells remaining in those chambers.
  • Mixing of the saline solution and cells is enhanced by rapid braking Using a rotor assembly and turntable substantially as I and acceleration of the rotor.
  • the cells are then centrifugally resedimented and the wash liquid drawn off into collection chamber 10 by applying vacuum through passageways 2.
  • Vents 11' provide communication between vacuum nnulus l2 and collecton chamber 10, thereby causing reduced pressure in that chamber and the resultant transfer of the saline wash solution from chambers 4 in a manner similar to that used to transfer the plasma fraction to collection chambers 10. The washing step is repeated as needed to achieve the desired cleansing action.
  • the rotor assembly is stopped and outer rotor portion 9 replaced with an outer rotor portion having individual collection chambers 10 identical to that used in the collection of plasma fractions.
  • the rotor assembly is then accelerated and lyzing liquid such as distilled water distributed to respective chambers 4 by injecting it into dynamic distribution port 6 in the same manner as the aforementioned wash solu tion.
  • I-Iemolysate is recovered by (1) dynamically introducing carbon tetrachloride into port 6 to settle cell debris against the centrifugal end of the chambers 4 and to centripetally displace the hemolysate and (2) applying vacuum through passageways 2 so as to cause the lysate to pass through passageways 8 to respective collection chambers 10.
  • Sufficient carbon tetrachloride can be used to displace the hemolysate to a point where the carbon tetrachloride-hemolysate interface is just centrifugal to the opening of passageways 8 in chambers 4.
  • recovery can be effected by (l) centrifugally compacting cell debris against the centrifugal end of chambers 4, (2) bringing the rotor assembly to a standstill, and (3) applying vacuum through passageways 2.
  • an outer rotor portion defining sample analysis cuvettes as shown in FIG. 4 can be used to collect those fractions.
  • the cuvettes can be preloaded with reactants and the entire rotor assembly disposed in a fast analyzer system as referenced above or the outer rotor portion containing the cuvettes transferred to a fast analyzer where both reagent addition and photometric analysis functions are performed. Subsequent washing and lyzing of the cell fraction can be carried out in the manner described above.
  • all or part of the washed blood cell fractions may be recovered for testing or storage for future comparison.
  • recovery is effected with the rotor assembly at rest or at low speed by applying vacuum to passageways 2, thereby causing cells filling the bottoms of chambers 4 to pass through passageways 8.
  • the cells are collected in respective collection chambers in an outer rotor portion identical to that used to collect plasma fractions. Where only part of the cell fractions is recovered, the remaining cell fractions can be lyzed and the lysate recovered in the manner previously described.
  • passageways 8 may extend from the sides rather than the bottoms of chambers 4 if transfer of chamber contents under dynamic conditions only is contemplated. It is necessary, however, that passageway 8 extend radially inward to a point centripetal to the maximum centripetal level of sample liquid in chamber 4 to avoid overflow of the sample during rotation. Likewise, passageways 7 and 8 should extend upward to a level sufficient to prevent overflow of sample liquid from chambers 4 under static conditions. it is intended, rather, that the invention be limited only by the scope of the appended claims.
  • a multiple-sample centrifugal rotor assembly for blood fraction preparation comprising:
  • an inner disk-shaped rotor portion having a top end surface, said inner rotor portion defining:
  • sample-receiving chambers i. a multiplicity of radially oriented samplereceiving chambers having centripetal and centrifugal ends, said sample-receiving chambers being disposed in a circular array;
  • each of said distribution passageways communicating between said dynamic distribution port and the centrifugal end of a respective sample-receiving chamber;
  • each of said transfer passageways communicating be tween one of said sample-receiving chambers at a point intermedite its centrifugal and centripetal ends and the radial periphery of said inner rotor portion, each of said transfer passageways extending radially inward from its point of communication with said sample-receiving chamber and then generally radially outward to said radial periphery of said inner rotor portion;
  • a removable outer rotor portion having an annular configuration nested concentrically 'about said inner rotor portion, said outer rotor portion defining at least one collection chamber in fluid communication with said transfer passageways in said inner rotor portion for receiving material discharaged from said transfer passageways.
  • each of said collection chambers is vented through the top surface of said outer rotor portion.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Centrifugal Separators (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US423381A 1973-12-10 1973-12-10 Multiple-sample rotor assembly for blood fraction preparation Expired - Lifetime US3864089A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US423381A US3864089A (en) 1973-12-10 1973-12-10 Multiple-sample rotor assembly for blood fraction preparation
BE151033A BE822803A (fr) 1973-12-10 1974-11-29 Rotor pour la preparation de fractions du sang d'echantillons multiples
ES432554A ES432554A1 (es) 1973-12-10 1974-12-04 Grupo rotor multimuestra para la preparacion de fraccion sanguinea.
FR7439884A FR2254027A1 (de) 1973-12-10 1974-12-05
NL7415917A NL7415917A (nl) 1973-12-10 1974-12-06 Meerdere monsters opnemend rotorstelsel voor bloedfractiepreparatie.
GB5317474A GB1451859A (en) 1973-12-10 1974-12-09 Multiple-sample rotor assembly for blood fraction preparation
AT981474A ATA981474A (de) 1973-12-10 1974-12-09 Mehrproben-rotoranordnung zur herstellung von blutfraktionen
JP49141222A JPS50114293A (de) 1973-12-10 1974-12-10
NO744440A NO744440L (de) 1973-12-10 1974-12-10
IT83642/74A IT1028560B (it) 1973-12-10 1974-12-10 Rotore centrifugo a campioni multipli per la preparazione di frazioni di sangue
DK641374A DK641374A (de) 1973-12-10 1974-12-10
SE7415499A SE7415499L (de) 1973-12-10 1974-12-10
DE19742458384 DE2458384A1 (de) 1973-12-10 1974-12-10 Mehrproben-rotoranordnung zur herstellung von blutfraktionen
AU76283/74A AU483685B2 (en) 1973-12-10 1974-12-11 Multiple-sample rotor assembly for blood fraction preparation
IL46233A IL46233A0 (en) 1973-12-10 1974-12-12 Multiple-sample rotor assembly for blood fraction preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US423381A US3864089A (en) 1973-12-10 1973-12-10 Multiple-sample rotor assembly for blood fraction preparation

Publications (1)

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US3864089A true US3864089A (en) 1975-02-04

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US (1) US3864089A (de)
JP (1) JPS50114293A (de)
AT (1) ATA981474A (de)
BE (1) BE822803A (de)
DE (1) DE2458384A1 (de)
DK (1) DK641374A (de)
ES (1) ES432554A1 (de)
FR (1) FR2254027A1 (de)
GB (1) GB1451859A (de)
IL (1) IL46233A0 (de)
IT (1) IT1028560B (de)
NL (1) NL7415917A (de)
NO (1) NO744440L (de)
SE (1) SE7415499L (de)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3951608A (en) * 1975-01-22 1976-04-20 Ernest Trod Mixing cuvette and timing turntable for providing reaction mixtures
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US4035156A (en) * 1977-01-21 1977-07-12 The United States Of America As Represented By The United States Energy Research And Development Administration Filter type rotor for multistation photometer
US4082732A (en) * 1975-07-29 1978-04-04 Immunology Research Foundation, Inc. Deblocking protein fraction recovery method and product
US4082733A (en) * 1975-07-29 1978-04-04 Immunology Research Foundation, Inc. Blocking protein fraction recovery method and product
FR2392725A1 (fr) * 1977-06-03 1978-12-29 Ibm Ensemble formant rotor de centrifugeuse et reservoir de fluide pour utilisation dans un tel ensemble
US4230264A (en) * 1978-02-17 1980-10-28 Akira Okumura Method and apparatus for centrifugal separation of components of solution
US4254084A (en) * 1978-04-21 1981-03-03 Blum Alvin S Method and apparataus for automatic isoenzyme analysis
EP0054262A1 (de) * 1980-12-15 1982-06-23 Jean Guigan Verfahren und Vorrichtung für die automatische simultane Analyse mehrerer Proben
US4343709A (en) * 1979-12-28 1982-08-10 Tetsuo Matsumoto Method and device for separately collecting and discharging components of liquid in centrifugal rotor
US4405079A (en) * 1980-11-10 1983-09-20 Haemonetics Corporation Centrifugal displacer pump
EP0211334A1 (de) * 1985-08-05 1987-02-25 Martin Marietta Energy Systems, Inc. Methode und Gerät zum automatischen Aufarbeiten und Aufteilen von Vollblutproben für die Analyse in einer Schnellanalysenzentrifuge
US4798577A (en) * 1986-05-12 1989-01-17 Miles Inc. Separator device and method
US5045047A (en) * 1989-07-17 1991-09-03 Zymark Corporation Automated centrifuge
US5114396A (en) * 1987-09-15 1992-05-19 Omega Medicinteknik Ab Method of washing blood cells and container assembly thereof
US5173193A (en) * 1991-04-01 1992-12-22 Schembri Carol T Centrifugal rotor having flow partition
US5242606A (en) * 1990-06-04 1993-09-07 Abaxis, Incorporated Sample metering port for analytical rotor having overflow chamber
US5256376A (en) * 1991-09-12 1993-10-26 Medical Laboratory Automation, Inc. Agglutination detection apparatus
WO1993022673A1 (en) * 1992-05-01 1993-11-11 Du Pont Canada Inc. Flow restrictor-separation device
US5409665A (en) * 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US5631166A (en) * 1995-03-21 1997-05-20 Jewell; Charles R. Specimen disk for blood analyses
US5650334A (en) * 1995-08-31 1997-07-22 First Medical, Inc. Fluorescent labelling compositions and methods for their use
US5693233A (en) * 1992-04-02 1997-12-02 Abaxis Methods of transporting fluids within an analytical rotor
US6299839B1 (en) 1995-08-31 2001-10-09 First Medical, Inc. System and methods for performing rotor assays
US20030173274A1 (en) * 2002-02-01 2003-09-18 Frank Corbin Blood component separation device, system, and method including filtration
US20030211928A1 (en) * 2001-09-24 2003-11-13 Dolecek Victor D. Method of separating and collecting components from a fluid
US6656105B2 (en) 1999-05-31 2003-12-02 Gambro, Inc. Centrifuge for processing blood and blood components in ring-type blood processing bags
US6689042B2 (en) 1997-02-12 2004-02-10 Gambro, Inc. Centrifuge and container system for treatment of blood and blood components
US6736768B2 (en) * 2000-11-02 2004-05-18 Gambro Inc Fluid separation devices, systems and/or methods using a fluid pressure driven and/or balanced approach
US6740239B2 (en) 1999-10-26 2004-05-25 Gambro, Inc. Method and apparatus for processing blood and blood components
US20060008381A1 (en) * 2002-10-28 2006-01-12 Takayuki Taguchi Analyzing tool and device
US20060144802A1 (en) * 2004-12-28 2006-07-06 Matsushita Electric Industrial Co., Ltd. Testing device and blood mixing and diluting method
US7279107B2 (en) 2002-04-16 2007-10-09 Gambro, Inc. Blood component processing system, apparatus, and method
US7347948B2 (en) 2001-04-09 2008-03-25 Ateriocyte Medical Systems, Inc. Blood centrifuge having clamshell blood reservoir holder with index line
US9079194B2 (en) 2010-07-19 2015-07-14 Terumo Bct, Inc. Centrifuge for processing blood and blood components
US20160199836A1 (en) * 2015-01-09 2016-07-14 Delta Electronics, Inc. Centrifugal channel device
US20160354774A1 (en) * 2015-06-07 2016-12-08 Delta Electronics, Inc. Centrifugal flow channel device and centrifugal flow channel body
CN106489072A (zh) * 2014-06-06 2017-03-08 豪夫迈·罗氏有限公司 具有计量室的用于分析生物样品的旋转筒
US10478817B2 (en) 2014-06-06 2019-11-19 Roche Diagnostics Operations, Inc. Rotatable cartridge for processing and analyzing a biological sample

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US4934995A (en) * 1977-08-12 1990-06-19 Baxter International Inc. Blood component centrifuge having collapsible inner liner
US5571068A (en) * 1977-08-12 1996-11-05 Baxter International Inc. Centrifuge assembly
US5217427A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Centrifuge assembly
US5217426A (en) * 1977-08-12 1993-06-08 Baxter International Inc. Combination disposable plastic blood receiving container and blood component centrifuge
US5006103A (en) * 1977-08-12 1991-04-09 Baxter International Inc. Disposable container for a centrifuge
FR2511153B1 (fr) * 1981-08-05 1986-01-10 Materiel Biomedical Support de reaction a recipients multiples pour tests de doses liquides
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
WO2018094012A1 (en) * 2016-11-16 2018-05-24 Quidel Coroporation Device for whole blood separation

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US3744975A (en) * 1971-12-09 1973-07-10 Atomic Energy Commission Rotor for multistation photometric analyzer
US3759666A (en) * 1971-12-09 1973-09-18 Union Carbide Corp Analytical process
US3795451A (en) * 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type

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US3291387A (en) * 1964-01-16 1966-12-13 Technicon Instr Continuous centrifugal separator
US3744975A (en) * 1971-12-09 1973-07-10 Atomic Energy Commission Rotor for multistation photometric analyzer
US3759666A (en) * 1971-12-09 1973-09-18 Union Carbide Corp Analytical process
US3795451A (en) * 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US3951608A (en) * 1975-01-22 1976-04-20 Ernest Trod Mixing cuvette and timing turntable for providing reaction mixtures
US4082732A (en) * 1975-07-29 1978-04-04 Immunology Research Foundation, Inc. Deblocking protein fraction recovery method and product
US4082733A (en) * 1975-07-29 1978-04-04 Immunology Research Foundation, Inc. Blocking protein fraction recovery method and product
US4035156A (en) * 1977-01-21 1977-07-12 The United States Of America As Represented By The United States Energy Research And Development Administration Filter type rotor for multistation photometer
FR2392725A1 (fr) * 1977-06-03 1978-12-29 Ibm Ensemble formant rotor de centrifugeuse et reservoir de fluide pour utilisation dans un tel ensemble
US4230264A (en) * 1978-02-17 1980-10-28 Akira Okumura Method and apparatus for centrifugal separation of components of solution
US4254084A (en) * 1978-04-21 1981-03-03 Blum Alvin S Method and apparataus for automatic isoenzyme analysis
US4343709A (en) * 1979-12-28 1982-08-10 Tetsuo Matsumoto Method and device for separately collecting and discharging components of liquid in centrifugal rotor
US4405079A (en) * 1980-11-10 1983-09-20 Haemonetics Corporation Centrifugal displacer pump
EP0054262A1 (de) * 1980-12-15 1982-06-23 Jean Guigan Verfahren und Vorrichtung für die automatische simultane Analyse mehrerer Proben
AU584443B2 (en) * 1985-08-05 1989-05-25 Lockheed Martin Energy Systems, Inc. Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
EP0211334A1 (de) * 1985-08-05 1987-02-25 Martin Marietta Energy Systems, Inc. Methode und Gerät zum automatischen Aufarbeiten und Aufteilen von Vollblutproben für die Analyse in einer Schnellanalysenzentrifuge
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NL7415917A (nl) 1975-06-12
ATA981474A (de) 1976-11-15
DE2458384A1 (de) 1975-06-26
IT1028560B (it) 1979-02-10
ES432554A1 (es) 1976-12-01
JPS50114293A (de) 1975-09-08
AU7628374A (en) 1976-06-17
DK641374A (de) 1975-08-11
GB1451859A (en) 1976-10-06
FR2254027A1 (de) 1975-07-04
BE822803A (fr) 1975-03-14
SE7415499L (de) 1975-06-11
IL46233A0 (en) 1975-03-13
NO744440L (de) 1975-07-07

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