GB1451859A - Multiple-sample rotor assembly for blood fraction preparation - Google Patents
Multiple-sample rotor assembly for blood fraction preparationInfo
- Publication number
- GB1451859A GB1451859A GB5317474A GB5317474A GB1451859A GB 1451859 A GB1451859 A GB 1451859A GB 5317474 A GB5317474 A GB 5317474A GB 5317474 A GB5317474 A GB 5317474A GB 1451859 A GB1451859 A GB 1451859A
- Authority
- GB
- United Kingdom
- Prior art keywords
- rotor
- passageways
- chambers
- chamber
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/07—Centrifugal type cuvettes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Centrifugal Separators (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
1451859 Centrifugal separator UNITED STATES ENERGY RESEARCH & DEVELOPMENT ADMINISTRATION 9 Dec 1974 [10 Dec 1973] 53174/74 Heading B2P A multi-sample centrifuge rotor for blood fraction preparation comprises: (a) an inner disc-shaped rotor portion 3, Fig. 1, having a top end surface and defining: (i) a plurality of radially oriented sample-receiving chambers 4 disposed in a circular array; (ii) a plurality of static sample-loading ports 5 each communicating between the top end surface of the rotor portion 3 and a respective samplereceiving chamber 4 for loading a blood sample into this chamber when the rotor is at rest; (iii) a centrally located dynamic distribution port 6 open to said top end surface; (iv) a plurality of distribution passageways 7 each communicating between the port 6 and the centrifugal end of a respective sample-receiving chamber 4 for supplying washing or haemolising liquid from the dynamic distribution port 6 to this chamber during rotation of the rotor; and (v) a plurality of transfer passageways 8 each communicating between a respective sample-receiving chamber 4, at a point intermediate its centrifugal and centripetal ends, and the radially outer periphery of the inner rotor portion 3, and each passageway extending radially inward from its point of communication with the respective chamber 4 and then generally radially outward to the radially outer periphery of the inner rotor portion; and (b) removable outer rotor portion, e.g. 9, nested concentrically about the inner rotor portion and defining at least one collection chamber 10 in fluid communication with a respective one, or all of, the transfer passageways 8 for receiving material discharged from the latter. The rotor is nested within a motor driven turntable 1 provided with passageways 2 communicating with a vacuum source (not shown). The rotor portion 9 has a plurality of collection chambers 10. Vents 11 extend from each collection chamber 10 to the top surface of rotor portion 9 and is then in communication with a respective vacuum passageway 2 via an annulus 12. The inner rotor portion is fabricated by machining cavities and channels into a plastics disc 17 which is sandwiched between and cemented to cover discs 18 and 19; all or part of the discs may be made of transparent plastics. Rotor portion 9 may be constructed in like manner. In operation, whole blood samples are first loaded through the ports 5 into the chambers 4 with the rotor at rest. The turntable and rotor are rotated at about 2,500 r.p.m. to separate the cells and plasma. The rotor is slowed down to about 1,000 r.p.m. and vacuum applied to passageways 8 to transfer plasma from the chambers 4 to the chambers 10 via the passageways 8. The rotor is stopped and its outer portion 9 is removed for recovery and testing of the plasma fractions. The portion 9 is replaced by an outer portion 9', Fig. 3, which has a single annular collection chamber 10' having an annular opening 21 in its inner peripheral wall. The reassembled rotor is rotated at about 2,000 r.p.m. and saline wash liquid is injected into port 6 and passes through the passageways 7 to the chambers 4 to wash the blood cells therein. Washing is enhanced by rapid braking and acceleration of the rotor. The wash liquid is then drawn off into the collection chamber 10' by application of vacuum through passageways 2 and vents 11' in the upper surface of the chamber. Washing may be repeated as desired. The rotor is again stopped and the outer portion 9' is then replaced by an outer portion identical to portion 9. The rotor is accelerated and haemolizing liquid, e.g. distilled water, is distributed into the chambers 4 via port 6 and passageways 7. Haemolysate is then displaced from the chambers 4 to the collection chambers 10 by injecting carbon tetrachloride into port 6 and applying vacuum through the passageways 2. Alternatively the blood cells can be centrifuged against the radially outer ends of the chambers 4, the rotor stopped and vacuum applied to the passageways 2 to effect displacement into the chambers 10. When it is desired to photometrically analyze the plasma fractions, an outer rotor portion 9", Fig. 4, having cuvettes 10" and transparent top and bottom plates 18", 19" can be used to collect those fractions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US423381A US3864089A (en) | 1973-12-10 | 1973-12-10 | Multiple-sample rotor assembly for blood fraction preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1451859A true GB1451859A (en) | 1976-10-06 |
Family
ID=23678697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5317474A Expired GB1451859A (en) | 1973-12-10 | 1974-12-09 | Multiple-sample rotor assembly for blood fraction preparation |
Country Status (14)
Country | Link |
---|---|
US (1) | US3864089A (en) |
JP (1) | JPS50114293A (en) |
AT (1) | ATA981474A (en) |
BE (1) | BE822803A (en) |
DE (1) | DE2458384A1 (en) |
DK (1) | DK641374A (en) |
ES (1) | ES432554A1 (en) |
FR (1) | FR2254027A1 (en) |
GB (1) | GB1451859A (en) |
IL (1) | IL46233A0 (en) |
IT (1) | IT1028560B (en) |
NL (1) | NL7415917A (en) |
NO (1) | NO744440L (en) |
SE (1) | SE7415499L (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4934995A (en) * | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US7695423B2 (en) | 2001-06-25 | 2010-04-13 | Terumo Medical Corporation | Method of simultaneous blood collection and separation using a continuous flow centrifuge having a separation channel |
CN110461473A (en) * | 2016-11-16 | 2019-11-15 | 奎多公司 | The device of whole blood separation |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3982691A (en) * | 1974-10-09 | 1976-09-28 | Schlutz Charles A | Centrifuge separation and washing device and method |
US3951608A (en) * | 1975-01-22 | 1976-04-20 | Ernest Trod | Mixing cuvette and timing turntable for providing reaction mixtures |
US4082732A (en) * | 1975-07-29 | 1978-04-04 | Immunology Research Foundation, Inc. | Deblocking protein fraction recovery method and product |
US4082733A (en) * | 1975-07-29 | 1978-04-04 | Immunology Research Foundation, Inc. | Blocking protein fraction recovery method and product |
US4035156A (en) * | 1977-01-21 | 1977-07-12 | The United States Of America As Represented By The United States Energy Research And Development Administration | Filter type rotor for multistation photometer |
US4430072A (en) * | 1977-06-03 | 1984-02-07 | International Business Machines Corporation | Centrifuge assembly |
US4230264A (en) * | 1978-02-17 | 1980-10-28 | Akira Okumura | Method and apparatus for centrifugal separation of components of solution |
US4254084A (en) * | 1978-04-21 | 1981-03-03 | Blum Alvin S | Method and apparataus for automatic isoenzyme analysis |
JPS5695354A (en) * | 1979-12-28 | 1981-08-01 | Akira Okumura | Dispensing and discharging method of liquid component in centrifugal rotor |
US4405079A (en) * | 1980-11-10 | 1983-09-20 | Haemonetics Corporation | Centrifugal displacer pump |
FR2496268A1 (en) * | 1980-12-15 | 1982-06-18 | Guigan Jean | AUTONOMOUS SIMULTANEOUS ANALYSIS DEVICE AND METHOD FOR IMPLEMENTING SAME |
FR2511153B1 (en) * | 1981-08-05 | 1986-01-10 | Materiel Biomedical | MULTIPLE CONTAINER REACTION HOLDER FOR TESTING LIQUID DOSES |
US4740472A (en) * | 1985-08-05 | 1988-04-26 | The United States Of America As Represented By The United States Department Of Energy | Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer |
US4798577A (en) * | 1986-05-12 | 1989-01-17 | Miles Inc. | Separator device and method |
SE462015B (en) * | 1987-09-15 | 1990-04-30 | Omega Medicinteknik Ab | SETTING AND DEVICE CLEANING BLOOD CELLS |
US5045047A (en) * | 1989-07-17 | 1991-09-03 | Zymark Corporation | Automated centrifuge |
US5242606A (en) * | 1990-06-04 | 1993-09-07 | Abaxis, Incorporated | Sample metering port for analytical rotor having overflow chamber |
US5173193A (en) * | 1991-04-01 | 1992-12-22 | Schembri Carol T | Centrifugal rotor having flow partition |
US5256376A (en) * | 1991-09-12 | 1993-10-26 | Medical Laboratory Automation, Inc. | Agglutination detection apparatus |
WO1993019827A1 (en) * | 1992-04-02 | 1993-10-14 | Abaxis, Inc. | Analytical rotor with dye mixing chamber |
US5282981A (en) * | 1992-05-01 | 1994-02-01 | E. I. Du Pont De Nemours And Company | Flow restrictor-separation device |
US5409665A (en) * | 1993-09-01 | 1995-04-25 | Abaxis, Inc. | Simultaneous cuvette filling with means to isolate cuvettes |
US5627041A (en) * | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
US5631166A (en) * | 1995-03-21 | 1997-05-20 | Jewell; Charles R. | Specimen disk for blood analyses |
US6299839B1 (en) | 1995-08-31 | 2001-10-09 | First Medical, Inc. | System and methods for performing rotor assays |
US5650334A (en) * | 1995-08-31 | 1997-07-22 | First Medical, Inc. | Fluorescent labelling compositions and methods for their use |
SE9700495D0 (en) | 1997-02-12 | 1997-02-12 | Omega Medicinteknik Ab | Method and round bag system and centrifuge for blood treatment |
SE516321C2 (en) | 1999-05-31 | 2001-12-17 | Gambro Inc | Centrifuge for the treatment of blood and blood components |
SE517032C2 (en) | 1999-10-26 | 2002-04-02 | Gambro Inc | Method and apparatus for treating blood and blood components |
ATE537907T1 (en) * | 2000-11-02 | 2012-01-15 | Caridianbct Inc | DEVICES, SYSTEMS AND METHODS FOR FLUID SEPARATION |
US6835316B2 (en) | 2001-04-09 | 2004-12-28 | Medtronic, Inc. | Clam shell blood reservoir holder with index line |
US6589153B2 (en) * | 2001-09-24 | 2003-07-08 | Medtronic, Inc. | Blood centrifuge with exterior mounted, self-balancing collection chambers |
US20030173274A1 (en) * | 2002-02-01 | 2003-09-18 | Frank Corbin | Blood component separation device, system, and method including filtration |
US7279107B2 (en) * | 2002-04-16 | 2007-10-09 | Gambro, Inc. | Blood component processing system, apparatus, and method |
JP4262466B2 (en) * | 2002-10-28 | 2009-05-13 | アークレイ株式会社 | Analysis tool and analyzer |
JP2008525791A (en) * | 2004-12-28 | 2008-07-17 | 松下電器産業株式会社 | Device for testing and blood mixture dilution method |
WO2012012343A1 (en) | 2010-07-19 | 2012-01-26 | Caridianbct, Inc. | A centrifuge for processing blood and blood components |
EP3151963B1 (en) * | 2014-06-06 | 2018-03-14 | Roche Diagnostics GmbH | Rotatable cartridge with a metering chamber for analyzing a biological sample |
EP2952257A1 (en) | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for processing and analyzing a biological sample |
TWI561808B (en) * | 2015-01-09 | 2016-12-11 | Delta Electronics Inc | Centrifugal channel device |
TWI562829B (en) * | 2015-06-17 | 2016-12-21 | Delta Electronics Inc | Centrifugal channel device and centrifugal channel main body |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3291387A (en) * | 1964-01-16 | 1966-12-13 | Technicon Instr | Continuous centrifugal separator |
BE792516A (en) * | 1971-12-09 | 1973-06-08 | Union Carbide Corp | RAPID SPECTROPHOTOMETRIC ANALYSIS PROCESS |
BE792465A (en) * | 1971-12-09 | 1973-03-30 | Atomic Energy Commission | PERFECTED ROTOR FOR ROTARY PHOTOMETRIC ANALYZER, ESPECIALLY SUITABLE IN WEIGHTNESS CONDITIONS |
US3795451A (en) * | 1973-04-24 | 1974-03-05 | Atomic Energy Commission | Rotor for fast analyzer of rotary cuvette type |
-
1973
- 1973-12-10 US US423381A patent/US3864089A/en not_active Expired - Lifetime
-
1974
- 1974-11-29 BE BE151033A patent/BE822803A/en unknown
- 1974-12-04 ES ES432554A patent/ES432554A1/en not_active Expired
- 1974-12-05 FR FR7439884A patent/FR2254027A1/fr not_active Withdrawn
- 1974-12-06 NL NL7415917A patent/NL7415917A/en unknown
- 1974-12-09 AT AT981474A patent/ATA981474A/en not_active Application Discontinuation
- 1974-12-09 GB GB5317474A patent/GB1451859A/en not_active Expired
- 1974-12-10 IT IT83642/74A patent/IT1028560B/en active
- 1974-12-10 NO NO744440A patent/NO744440L/no unknown
- 1974-12-10 DK DK641374A patent/DK641374A/da unknown
- 1974-12-10 SE SE7415499A patent/SE7415499L/ not_active Application Discontinuation
- 1974-12-10 JP JP49141222A patent/JPS50114293A/ja active Pending
- 1974-12-10 DE DE19742458384 patent/DE2458384A1/en active Pending
- 1974-12-12 IL IL46233A patent/IL46233A0/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4934995A (en) * | 1977-08-12 | 1990-06-19 | Baxter International Inc. | Blood component centrifuge having collapsible inner liner |
US5006103A (en) * | 1977-08-12 | 1991-04-09 | Baxter International Inc. | Disposable container for a centrifuge |
US5217426A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Combination disposable plastic blood receiving container and blood component centrifuge |
US5217427A (en) * | 1977-08-12 | 1993-06-08 | Baxter International Inc. | Centrifuge assembly |
US5571068A (en) * | 1977-08-12 | 1996-11-05 | Baxter International Inc. | Centrifuge assembly |
US5759147A (en) * | 1977-08-12 | 1998-06-02 | Baxter International Inc. | Blood separation chamber |
US7695423B2 (en) | 2001-06-25 | 2010-04-13 | Terumo Medical Corporation | Method of simultaneous blood collection and separation using a continuous flow centrifuge having a separation channel |
CN110461473A (en) * | 2016-11-16 | 2019-11-15 | 奎多公司 | The device of whole blood separation |
Also Published As
Publication number | Publication date |
---|---|
ATA981474A (en) | 1976-11-15 |
DE2458384A1 (en) | 1975-06-26 |
ES432554A1 (en) | 1976-12-01 |
DK641374A (en) | 1975-08-11 |
IL46233A0 (en) | 1975-03-13 |
AU7628374A (en) | 1976-06-17 |
FR2254027A1 (en) | 1975-07-04 |
BE822803A (en) | 1975-03-14 |
JPS50114293A (en) | 1975-09-08 |
US3864089A (en) | 1975-02-04 |
IT1028560B (en) | 1979-02-10 |
NL7415917A (en) | 1975-06-12 |
NO744440L (en) | 1975-07-07 |
SE7415499L (en) | 1975-06-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CSNS | Application of which complete specification have been accepted and published, but patent is not sealed |