US3856185A - Single dose, replaceable supply air pressure operated dispenser - Google Patents

Single dose, replaceable supply air pressure operated dispenser Download PDF

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Publication number
US3856185A
US3856185A US00427854A US42785473A US3856185A US 3856185 A US3856185 A US 3856185A US 00427854 A US00427854 A US 00427854A US 42785473 A US42785473 A US 42785473A US 3856185 A US3856185 A US 3856185A
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United States
Prior art keywords
product
compressed air
dispensing
flow path
air flow
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Expired - Lifetime
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US00427854A
Inventor
P Riccio
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Novartis Corp
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Ciba Geigy Corp
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Publication date
Application filed by Ciba Geigy Corp filed Critical Ciba Geigy Corp
Priority to US00427854A priority Critical patent/US3856185A/en
Priority to SE7415242A priority patent/SE407752B/en
Priority to NL7416073A priority patent/NL7416073A/en
Priority to CH1689774A priority patent/CH588392A5/xx
Priority to AU76710/74A priority patent/AU481744B2/en
Priority to FR7442499A priority patent/FR2256085B1/fr
Priority to ZA00748175A priority patent/ZA748175B/en
Priority to IT54729/74A priority patent/IT1026139B/en
Priority to DK679274AA priority patent/DK140245B/en
Priority to GB55673/74A priority patent/GB1488920A/en
Priority to DE2461376A priority patent/DE2461376C3/en
Priority to ES433297A priority patent/ES433297A1/en
Application granted granted Critical
Priority to CA216,796A priority patent/CA1010425A/en
Publication of US3856185A publication Critical patent/US3856185A/en
Priority to JP49148557A priority patent/JPS5096908A/ja
Priority to BE151949A priority patent/BE823884A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/008—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised by squeezing, e.g. using a flexible bottle or a bulb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • ABSTRACT A single dose dispensing device for aspirating a product located in a replaceable container by means of compressed air is disclosed.
  • the device includes a piston-cylinder assemblyhaving a movable member and a fixed member and has a compressed air flow path therethrough with an aperture at the free end of the fixed member.
  • a product dispensing member also having a compressed air flow path therethrough is connected to the piston-cylinder assembly, the respective compressed airflow paths being in communication with one another.
  • the dispensing member further includes a product storing chamber and anaspirating means in communication with both the product storing chamber and the compressed air flow path.
  • a diaphragm member normally blocks the compressed air flow path and is adapted to open when the movable member substantially completes a compression stroke,
  • the invention relates to a dispenser and particularly to a device for dispensing a single dose of material preferably powder, by means of aspiration using compressed air, and in which the supply of dispensed material is readily replaceable.
  • fluorocarbon propellants e.g. Freon which is a commonly used propellant
  • Freon which is a commonly used propellant
  • Pharmaceutical marketers would thus prefer to have the product dispensed by air instead of the chemical vapor conventionally used as a propellant.
  • a further disadvantage of the prior art dispensing devices is leakage of propellant from the propellant car tridge during storage, which reduces the shelf life of the dispenser. Additionally, the problem of exactly matching the amount of propellant with the amount of material to be dispensed is often difficult because of leakage problem. Also because of differences between the various materials being dispensed a proper amount of propellant for the material will not suffice or will be in excess of that necessary for dispensing all of another material. In the first instance, part of the product is wasted and in the second instance part of the propellant is wasted.
  • a further disadvantage is that, with compressed gas type propellants when the propellant is running low, the dispensing of the last of the material to be dispensed can be carried out only at a very slow rate, as compared to when the dispenser is initially filled with propellant, when dispensing takes place rapidly.
  • the diaphragm member seals the compressed air flow path when product is not being dispensed.
  • a dispensing device having a piston-cylinder assembly defining a compressed air flow path therethrough and having a piston slidable therein.
  • a single dose, replaceable product dispensing member having aspirating means is removably connected to the piston-cylinder assmbly such that the aspirating means communicates with the compressed air flow path therein.
  • the product dispensing member has adiaphragm member operatively positioned across the compressed air flow path.
  • the pistoncylinder assembly preferably has a cylinder around the compressed air flow path and has a piston slidable therein.
  • a piston rod is connected to the piston for moving the piston into the cylinder.
  • FIG. 1 is a side view of the device constructed in accordance with a subject disclosure
  • FIG. 2 is a sectional elevation view of the device of 5 FIG. 1 with the parts in the rest or non-dispensing position.
  • FIG. 1 a side view of a configuration of the subject invention is disclosed.
  • a single dose, replaceable product dispensing member is inserted within and retained by a dispenser l2 and operatively communicates therewith.
  • the dispenser 12 has a piston which is operated by means of piston rod 18 to produce a compressed air supply which is fed to the product dispensing member 10 for aspiration ofthe material, preferably powder, contained in the member.
  • FIG. 2 discloses a cross sectional elevation view of the device of FIG. 1, the compressed air is generated by an air compressing pistoncylinder means which may be a hollow cylinder 14 having an aperture at one end and an aperture in the lateral surface of the cylinder at the opposite end thereof.
  • a piston member 16 is slidably positioned within the cylinder l4 and the piston rod 18 is an extension thereof which extends through the end aperture of the cylinder 14.
  • the piston member 16 has a piston face 20, the piston being slidably retained within the cylinder by means of retaining cap 22.
  • the cylinder further includes a partition member 24 having an aperture 26 therein.
  • a probe member 28 protrudes from the face of the piston in alignment with the aperture 26.
  • Compression ring 30 seals the piston head in its movement within the cylinder 14 and a return spring 32 within the cylinder normally urges the piston away from the partition member 24.
  • the piston, the partition and the cylinder define a chamber 34 for compressing air.
  • Product dispensing member 10 is a sepa'rate replaceable body which is insertable through the first lateral aperture in the cylinder as shown.
  • the dispensing end of the member 10 has an outer annular channel 36 and an inner recessed region 38 having a central passageway 39 extending from the recessed region 38 and intersecting a lateral opening 40 of a larger diameter which opens laterally out of the member 10.
  • a Venturi nozzle insert 42 is seated in the inner recessed region 38 and an aperture cover 44 sits within the annular channel 36 and fits over the Venturi nozzle insert 42; an elongated extension 46 fitting tightly against the peripheral wall 48 of the dispensing member 10.
  • a tab seal 50 is provided over an aperture in the cover and the Venturi nozzle and is removed prior to operation of the device.'This tab seal insures that the product will not become contaminated and also prevents the unintentional egress of product from the device.
  • the Venturi nozzle 42, cover 44 and member 10 define a supply chamber 45 from which passages 47 open into the central passage of nozzle 42.
  • Supply chamber 45 can be filled by loading a preferably powdered product through material supply passageway 52 which communicates with the supply chamber.
  • a thumb knockout pin 54 may optionally be provided on the dispensing member.
  • the cylinder 14 has a second lateral aperture 56 through which extends the thumb knockout pin 54.
  • An air tight seal 58 is provided over the back of member 10 to prevent leakage of compressed air, to seal the supply passageway 52, to protect the .product contained in the supply chamber from contamination and to retain the product therein.
  • the air flow path-which begins at the passageway 39 is normally blocked by solid, breakable diaphragm member 60 which is preferably seated in a recessed region of the dispensing member 10 in coaxial relationship with lateral opening 40.
  • the diaphragm member may be constructed of paper, plastic or the like and fits snugly within the recess to block the compressed air flow path.
  • the diaphragm member initially acts, in combination with the partition member 24, as an end of a compression chamber; the other end being formed member is broken, compressed air surges through passageway 39 and into the Venturi nozzle 42 and the material in supply chamber 45 is aspirated therefrom and dispensed through theVenturi nozzle 42.
  • the memberlO contains a single dose of product and may be removed, for instanceby pressing the thumb knockout pin 54, from the dispenser and a new capsule may be coupled thereto in preparation'for the next dispensing operation.
  • the piston 16, upon release, returns to its initial position due to the force exerted by the spring 32.
  • a single dose replaceable product supply dispensing device comprising: I v a piston-cylinder means having a movable member and a fixed member having a compressed air flow path therethrough with an aperture at thelend remote from said movable member;
  • a single dose replaceable product dispensing member having a product dispensing aperture and adapted to be operatively connected to said fixed member and having a compressed air fiow path therethrough, said fiow path being operatively positioned relative to said compressed air flow path of said piston-cylinder means when said product dispensing member is connected to said fixed member for communication therebetween, said dispensing member further having a product supply chamber, and aspirating means in said compressed air flow path communicating with said product supply chamber for dispensing said product via said product dispensing aperture;
  • a diaphragm member normally blocking the compressed air flow path and adapted to open only when said movable member approaches thereto, during its compression stroke;
  • said diaphragm member being a solid breakable member and said de- 4.
  • said cylinder further having an aperture in the lateral surface thereof and. said product dispensing member being insertable therethrough whereby said product dispensing member is operatively seated within said cylinder.
  • said aspirating means is a Venturi nozzle insert member in said compressed air flow path and having lateral passages extending to said product containing chamber, said product being aspirated by said compressed air flow through said nozzle and being dispensed through said nozzle.
  • said product dispensing member further comprises a thumb knockout pin extending from an end of said product dispensing member opposite said product dispensing aperture and said cylinder further having a second lateral aperture opposite said first lateral aperture, said pin extending through said second lateral aperture.
  • said product dispensing member further comprises an annular cartridge member having a substantially cylindrical shape
  • said cartridge member further has a material filling passageway communicating with said product supply chamber and the opposite end of said cartridge member.
  • the device of claim 8 further comprising a first removable sealing member positioned over said Ven-' turi'nozzle for preventing contamination of the product contained therein and a second sealing member positioned over the opposite end of said member.
  • a single dose replaceable product dispensing member for dispensing a product by means of compressed air supplied by a dispensing device comprising:
  • a dispensing member body one end thereof having an outer annular channel and an inner recessed portion, a first aperture within said inner recessed portion, a second aperture through which compressed air may be admitted to said dispensing member, a compressed air flow path between said first andsecond apertures, aspirating means comprised of a Venturi nozzle insert member having a central air passageway positioned within said inner recessed portion in operative alignment with said first aperture and receiving compressed air therefrom, said Venturi nozzle insert member further having lateral passageways extending from the central air passageway to the periphery of a cover member having a central aperture positioned over said one end of said dispensing member said central aperture being in alignment with said Venturi nozzle insert member, said cover member, said Venturi nozzle insert member and said dispensing member body defining a product supply chamber, said product supply chamber communicating with the central passageway of said nozzle insert member through said lateral passageways, and a material filling passageway intersecting said product supply chamber in said outer annular channel and intersecting an opposite end of said dispens

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)

Abstract

A single dose dispensing device for aspirating a product located in a replaceable container by means of compressed air is disclosed. The device includes a piston-cylinder assembly having a movable member and a fixed member and has a compressed air flow path therethrough with an aperture at the free end of the fixed member. A product dispensing member, also having a compressed air flow path therethrough is connected to the piston-cylinder assembly, the respective compressed air flow paths being in communication with one another. The dispensing member further includes a product storing chamber and an aspirating means in communication with both the product storing chamber and the compressed air flow path. A diaphragm member normally blocks the compressed air flow path and is adapted to open when the movable member substantially completes a compression stroke, thus allowing product to be dispensed by means of compressed air.

Description

United States Patent 1 Riccio [45 Dec. 24, 1974 SINGLE DOSE, REPLACEABLE SUPPLY- AIR PRESSURE OPERATED DISPENSER Inventor:
[73] Assignee:
Filed:
Appl. No.:
Dec. 26, 1973 Pasquale R. Riccio, Salem, N.H.
Ciba-Geigy Corporation, Ardsley, N.Y.
US. Cl 222/193, 128/266, 239/309 Int. Cl B67d 5/54 Field of Search 222/83, 193, 145, 391;
References Cited UNITED STATES PATENTS 8/1950 Fields 4/1966 11/1970 Oakes Corsette et a1.
Wells 222/193 X 128/266 222/385 X Solowey 222/83 FOREIGN PATENTS OR APPLICATIONS l l l n Great Britain 128/265 Primary Examiner-Stanley 1-1. Tollberg Assistant Examiner-Norman L. Stack, Jr. Att0rney,'Agent, or Firm-Wenderoth, Lind & Ponack [57] ABSTRACT A single dose dispensing device for aspirating a product located in a replaceable container by means of compressed air is disclosed. The device includes a piston-cylinder assemblyhaving a movable member and a fixed member and has a compressed air flow path therethrough with an aperture at the free end of the fixed member. A product dispensing member, also having a compressed air flow path therethrough is connected to the piston-cylinder assembly, the respective compressed airflow paths being in communication with one another. The dispensing member further includes a product storing chamber and anaspirating means in communication with both the product storing chamber and the compressed air flow path. A diaphragm member normally blocks the compressed air flow path and is adapted to open when the movable member substantially completes a compression stroke,
thus allowing product to be dispensed by means of compressed air.
10 Claims, 2 Drawing Figures BACKGROUND OF THE DEVICE 1. Field of the Invention The invention relates to a dispenser and particularly to a device for dispensing a single dose of material preferably powder, by means of aspiration using compressed air, and in which the supply of dispensed material is readily replaceable.
2. Description of the Prior Art The art of dispensing material is highly developed. Recently there have been great advances in the art of dispensing materials by means of a compressed propellant while keeping the material and propellant separate prior to dispensing. This is typified by the recently developed so-called double aerosol type dispensers which are quite satisfactory, but nevertheless have some disadvantages, particularly where they must be made in small sizes.
A most serious disadvantage arises from the fact that so-called aerosol propellants are used to dispense the material. When medicaments are dispensed from the inhaler type devices, these propellants are inhaled by.
the user along with the medicament. It has recently been reported that fluorocarbon propellants, e.g. Freon which is a commonly used propellant, may be highly toxic, and the same situation may be found to hold true for other propellants. Pharmaceutical marketers would thus prefer to have the product dispensed by air instead of the chemical vapor conventionally used as a propellant.
A further disadvantage of the prior art dispensing devices is leakage of propellant from the propellant car tridge during storage, which reduces the shelf life of the dispenser. Additionally, the problem of exactly matching the amount of propellant with the amount of material to be dispensed is often difficult because of leakage problem. Also because of differences between the various materials being dispensed a proper amount of propellant for the material will not suffice or will be in excess of that necessary for dispensing all of another material. In the first instance, part of the product is wasted and in the second instance part of the propellant is wasted.
A further disadvantage is that, with compressed gas type propellants when the propellant is running low, the dispensing of the last of the material to be dispensed can be carried out only at a very slow rate, as compared to when the dispenser is initially filled with propellant, when dispensing takes place rapidly.
Many of these disadvantages could be overcome if, instead of using compressed conventional propellant gases, air was used as a propellant and was compressed each time the dispensing operation was to be. carried out. Conventional squeeze bulb and piston-cylinder atomizers operate somewhat in this fashion bu have the serious drawback that the compression is carried out gradually, the amount of material dispensed being dependent on how fast and with what force the squeeze bulb or'the piston-cylinder means is operated. They very often include a check valve at the delivery end of the cylinder, but this valve does not provide any significant resistance to flow of compressed gas once the piston starts to move into the cylinder. v
A number of devices have recently been invented which use charges of compressed air which are produced at each actuation of the device. However, these devices tend to be somewhat complex and hence rather expensive to make.
Technical progress would be achieved if there could be provided a simply constructed device which would dispense single doses of product with air compressed as the device is actuated under the control of a very simple and easily made means, the parts of which device would be simple to mold in plastic, and which could have the product supply readily replaced.
OBJECTS AND SUMMARY OF THE INVENTION It is an object of the present invention to provide a simple and compact single dose dispensing device having a replaceable supply cartridge, which utilizes compressed air for aspiration in a manner so as to overcome. all of the recited disadvantages of the prior art dispensers.
It is further object of the present invention to provide a simple and compact single dose dispensing device having a replaceable supply cartridge which utilizes compressed air that is compressed as the dispensing takes place, but which releases the compressed air only after the pressure has built to a desired level.
It is a still further object of the present invention to provide a simple and compact dispensing device which can be stored without loss of a propellant and without a product container, therefore having an unlimited shelf life, which can also be stored without fear of an explosion of a compressed propellant and which can be shipped in interstate commerce as a non-pressurized item, thereby eliminating the need for special packaging and labeling.
It is a still further object of the invention to provide a simple and compact single dose dispensing device having a replaceable supply cartridge, preferably for a powdered medicament, which has a positively operated simple diaphragm member in a compressed airflow path between a piston and aspirating means. The diaphragm member seals the compressed air flow path when product is not being dispensed.
These objects are achieved by providing a dispensing device having a piston-cylinder assembly defining a compressed air flow path therethrough and having a piston slidable therein. A single dose, replaceable product dispensing member having aspirating means is removably connected to the piston-cylinder assmbly such that the aspirating means communicates with the compressed air flow path therein. The product dispensing member has adiaphragm member operatively positioned across the compressed air flow path.'The pistoncylinder assembly preferably has a cylinder around the compressed air flow path and has a piston slidable therein. A piston rod is connected to the piston for moving the piston into the cylinder. When the piston 1 reaches substantially the inner end of the cylinder, the
diaphragm member and consequently the compressed air flow path opens, thus releasingthe compressed air 'from the cylinder. The actuation of the aspirating means in response to the compressed air causes the product to be dispensed. The dispensing member is then replaced by a full one. All of the parts of the device are easily molded in plastic and easily assembled.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a side view of the device constructed in accordance with a subject disclosure;
FIG. 2 is a sectional elevation view of the device of 5 FIG. 1 with the parts in the rest or non-dispensing position.
DETAILED DESCRIPTION OF THE INVENTION Referring first to FIG. 1, a side view of a configuration of the subject invention is disclosed. A single dose, replaceable product dispensing member is inserted within and retained by a dispenser l2 and operatively communicates therewith. The dispenser 12 has a piston which is operated by means of piston rod 18 to produce a compressed air supply which is fed to the product dispensing member 10 for aspiration ofthe material, preferably powder, contained in the member.
Next, referring to FIG. 2, which discloses a cross sectional elevation view of the device of FIG. 1, the compressed air is generated by an air compressing pistoncylinder means which may be a hollow cylinder 14 having an aperture at one end and an aperture in the lateral surface of the cylinder at the opposite end thereof. A piston member 16 is slidably positioned within the cylinder l4 and the piston rod 18 is an extension thereof which extends through the end aperture of the cylinder 14. The piston member 16 has a piston face 20, the piston being slidably retained within the cylinder by means of retaining cap 22. The cylinder further includes a partition member 24 having an aperture 26 therein. A probe member 28 protrudes from the face of the piston in alignment with the aperture 26.
Compression ring 30 seals the piston head in its movement within the cylinder 14 and a return spring 32 within the cylinder normally urges the piston away from the partition member 24. The piston, the partition and the cylinder define a chamber 34 for compressing air.
Product dispensing member 10 is a sepa'rate replaceable body which is insertable through the first lateral aperture in the cylinder as shown. The dispensing end of the member 10 has an outer annular channel 36 and an inner recessed region 38 having a central passageway 39 extending from the recessed region 38 and intersecting a lateral opening 40 of a larger diameter which opens laterally out of the member 10. A Venturi nozzle insert 42 is seated in the inner recessed region 38 and an aperture cover 44 sits within the annular channel 36 and fits over the Venturi nozzle insert 42; an elongated extension 46 fitting tightly against the peripheral wall 48 of the dispensing member 10. A tab seal 50 is provided over an aperture in the cover and the Venturi nozzle and is removed prior to operation of the device.'This tab seal insures that the product will not become contaminated and also prevents the unintentional egress of product from the device.
The Venturi nozzle 42, cover 44 and member 10 define a supply chamber 45 from which passages 47 open into the central passage of nozzle 42. Supply chamber 45 can be filled by loading a preferably powdered product through material supply passageway 52 which communicates with the supply chamber. A thumb knockout pin 54 may optionally be provided on the dispensing member. The cylinder 14 has a second lateral aperture 56 through which extends the thumb knockout pin 54. An air tight seal 58 is provided over the back of member 10 to prevent leakage of compressed air, to seal the supply passageway 52, to protect the .product contained in the supply chamber from contamination and to retain the product therein.
The air flow path-which begins at the passageway 39 is normally blocked by solid, breakable diaphragm member 60 which is preferably seated in a recessed region of the dispensing member 10 in coaxial relationship with lateral opening 40. The diaphragm member may be constructed of paper, plastic or the like and fits snugly within the recess to block the compressed air flow path. The diaphragm member initially acts, in combination with the partition member 24, as an end of a compression chamber; the other end being formed member is broken, compressed air surges through passageway 39 and into the Venturi nozzle 42 and the material in supply chamber 45 is aspirated therefrom and dispensed through theVenturi nozzle 42.
Operation of the device is as follows:
When pressure is exerted by the fingers of the user on the piston rod 18, air is compressed in the cylinder 14 ahead of the piston face 20. The diaphragm member 60 blocks the passage of air until the piston reaches the end of its stroke, at which time the diaphragm member opens and the compressed air in the cylinder is suddenly released to flow through the compressed air flow path and the product dispensing member, causing aspiration of the product as described above.
The memberlO contains a single dose of product and may be removed, for instanceby pressing the thumb knockout pin 54, from the dispenser and a new capsule may be coupled thereto in preparation'for the next dispensing operation. The piston 16, upon release, returns to its initial position due to the force exerted by the spring 32. v
It will be seen that a simple diaphragm is provided in the replaceable member 10. instead of there being a more complex valve and spring arrangement. All of the parts are easily molded of plastic, except for return spring 32, so that the device is easily and inexpensively manufactured. v
It is thought that the invention and its advantages will be understood from the foregoing description, and it is apparent that various changes may be made in the form, construction and arrangement of the parts without departing from the spirit and scope of the invention or sacrificing its material advantages, the form hereinbefore described and illustrated in the drawings being merely a preferred embodiment thereof.
I claim:
1. A single dose replaceable product supply dispensing device comprising: I v a piston-cylinder means having a movable member and a fixed member having a compressed air flow path therethrough with an aperture at thelend remote from said movable member;
a single dose replaceable product dispensing member having a product dispensing aperture and adapted to be operatively connected to said fixed member and having a compressed air fiow path therethrough, said fiow path being operatively positioned relative to said compressed air flow path of said piston-cylinder means when said product dispensing member is connected to said fixed member for communication therebetween, said dispensing member further having a product supply chamber, and aspirating means in said compressed air flow path communicating with said product supply chamber for dispensing said product via said product dispensing aperture; and
a diaphragm member normally blocking the compressed air flow path and adapted to open only when said movable member approaches thereto, during its compression stroke;
whereby as said movable member moves toward said fixed member in a compression stroke, air is compressed in the fixed member, said diaphragm member remaining closed until said movable member substantially reaches the end of its compression stroke whereupon said diaphragm member opens, allowing compressed air to travel along said compressed air flow path into said product dispensing member and through said aspirating means, product being dispensed thereby.
2. In the dispensing device of claim 1, said diaphragm member being a solid breakable member and said de- 4. In the dispensing device of claim 3, said cylinder further having an aperture in the lateral surface thereof and. said product dispensing member being insertable therethrough whereby said product dispensing member is operatively seated within said cylinder.
5. The device of claim 4, wherein said aspirating means is a Venturi nozzle insert member in said compressed air flow path and having lateral passages extending to said product containing chamber, said product being aspirated by said compressed air flow through said nozzle and being dispensed through said nozzle.
6. The device of claim 5, wherein said product dispensing member further comprises a thumb knockout pin extending from an end of said product dispensing member opposite said product dispensing aperture and said cylinder further having a second lateral aperture opposite said first lateral aperture, said pin extending through said second lateral aperture.
7. The device of claim 6, wherein said product dispensing member further comprises an annular cartridge member having a substantially cylindrical shape,
and having opposite ends, one end thereof having an outer annular channel and an inner recessed portion, said compressed air flow path extending from said recessed portion to the lateral surface of said annular cartridge member, said Venturi nozzle insert being seated within said inner recessed portion, a cartridge cover having a central aperture and having an elongated portion positioned within said outer annular channel, said central passage being positioned in alignment with said Venturi nozzle and said cartridge cover, said Venturi nozzle insert and said cartridge member end forming said product supply chamber.
8. The device of claim 7, wherein said cartridge member further has a material filling passageway communicating with said product supply chamber and the opposite end of said cartridge member.
9. The device of claim 8, further comprising a first removable sealing member positioned over said Ven-' turi'nozzle for preventing contamination of the product contained therein and a second sealing member positioned over the opposite end of said member.
10. A single dose replaceable product dispensing member for dispensing a product by means of compressed air supplied by a dispensing device, comprising:
a dispensing member body, one end thereof having an outer annular channel and an inner recessed portion, a first aperture within said inner recessed portion, a second aperture through which compressed air may be admitted to said dispensing member, a compressed air flow path between said first andsecond apertures, aspirating means comprised of a Venturi nozzle insert member having a central air passageway positioned within said inner recessed portion in operative alignment with said first aperture and receiving compressed air therefrom, said Venturi nozzle insert member further having lateral passageways extending from the central air passageway to the periphery of a cover member having a central aperture positioned over said one end of said dispensing member said central aperture being in alignment with said Venturi nozzle insert member, said cover member, said Venturi nozzle insert member and said dispensing member body defining a product supply chamber, said product supply chamber communicating with the central passageway of said nozzle insert member through said lateral passageways, and a material filling passageway intersecting said product supply chamber in said outer annular channel and intersecting an opposite end of said dispensing member whereby product may be supplied to said chamber and a diaphragm member normally blocking said compressed air-flow path and adpated to open when the pressure of said compressed air supplied to said dispensing member exceeds a predetermined value whereby compressed air aspirates product as the compressed air passes through said Venturi nozzle member insert, product being thereby dispensed.

Claims (10)

1. A single dose replaceable product supply dispensing device comprising: a piston-cylinder means having a movable member and a fixed member having a compressed air flow path therethrough with an aperture at the end remote from said movable member; a single dose replaceable product dispensing member having a product dispensing aperture and adapted to be operatively connected to said fixed member and having a compressed air flow path therethrough, said flow path being operatively positioned relative to said compressed air flow path of said pistoncylinder means when said product dispensing member is connected to said fixed member for communication therebetween, said dispensing member further having a product supply chamber, and aspirating means in said compressed air flow path communicating with said product supply chamber for dispensing said product via said product dispensing aperture; and a diaphragm member normally blocking the compressed air flow path and adapted to open only when said movable member approaches thereto, during its compression stroke; whereby as said movable member moves toward said fixed member in a compression stroke, air is compressed in the fixed member, said diaphragm member remaining closed until said movable member substantially reaches the end of its compression stroke whereupon said diaphragm member opens, allowing compressed air to travel along said compressed air flow path into said product dispensing member and through said aspirating means, product being dispensed thereby.
2. In the dispensing device of claim 1, said diapHragm member being a solid breakable member and said device further comprising a perforating member positioned on and extending from said movable member toward said diaphragm member, the length of said perforating member being such that said diaphragm member is ruptured near the end of the compression stroke of said movable member.
3. The dispensing device of claim 2, wherein said product dispensing member has a peripheral recess about the compressed air flow path thereof, said diaphragm member being air tightly seated in said recess.
4. In the dispensing device of claim 3, said cylinder further having an aperture in the lateral surface thereof and said product dispensing member being insertable therethrough whereby said product dispensing member is operatively seated within said cylinder.
5. The device of claim 4, wherein said aspirating means is a Venturi nozzle insert member in said compressed air flow path and having lateral passages extending to said product containing chamber, said product being aspirated by said compressed air flow through said nozzle and being dispensed through said nozzle.
6. The device of claim 5, wherein said product dispensing member further comprises a thumb knockout pin extending from an end of said product dispensing member opposite said product dispensing aperture and said cylinder further having a second lateral aperture opposite said first lateral aperture, said pin extending through said second lateral aperture.
7. The device of claim 6, wherein said product dispensing member further comprises an annular cartridge member having a substantially cylindrical shape, and having opposite ends, one end thereof having an outer annular channel and an inner recessed portion, said compressed air flow path extending from said recessed portion to the lateral surface of said annular cartridge member, said Venturi nozzle insert being seated within said inner recessed portion, a cartridge cover having a central aperture and having an elongated portion positioned within said outer annular channel, said central passage being positioned in alignment with said Venturi nozzle and said cartridge cover, said Venturi nozzle insert and said cartridge member end forming said product supply chamber.
8. The device of claim 7, wherein said cartridge member further has a material filling passageway communicating with said product supply chamber and the opposite end of said cartridge member.
9. The device of claim 8, further comprising a first removable sealing member positioned over said Venturi nozzle for preventing contamination of the product contained therein and a second sealing member positioned over the opposite end of said member.
10. A single dose replaceable product dispensing member for dispensing a product by means of compressed air supplied by a dispensing device, comprising: a dispensing member body, one end thereof having an outer annular channel and an inner recessed portion, a first aperture within said inner recessed portion, a second aperture through which compressed air may be admitted to said dispensing member, a compressed air flow path between said first and second apertures, aspirating means comprised of a Venturi nozzle insert member having a central air passageway positioned within said inner recessed portion in operative alignment with said first aperture and receiving compressed air therefrom, said Venturi nozzle insert member further having lateral passageways extending from the central air passageway to the periphery of a cover member having a central aperture positioned over said one end of said dispensing member said central aperture being in alignment with said Venturi nozzle insert member, said cover member, said Venturi nozzle insert member and said dispensing member body defining a product supply chamber, said product supply chamber communicating with the central passageway of said nozzle insert member through said lateral passageways, and a material filling passageway intersecting said product supply chamber in said outer annular channel and intersecting an opposite end of said dispensing member whereby product may be supplied to said chamber and a diaphragm member normally blocking said compressed air flow path and adpated to open when the pressure of said compressed air supplied to said dispensing member exceeds a predetermined value whereby compressed air aspirates product as the compressed air passes through said Venturi nozzle member insert, product being thereby dispensed.
US00427854A 1973-12-26 1973-12-26 Single dose, replaceable supply air pressure operated dispenser Expired - Lifetime US3856185A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US00427854A US3856185A (en) 1973-12-26 1973-12-26 Single dose, replaceable supply air pressure operated dispenser
SE7415242A SE407752B (en) 1973-12-26 1974-12-05 SPRAYER DISTRIBUTOR FOR LIQUID PRODUCT
NL7416073A NL7416073A (en) 1973-12-26 1974-12-10 SPRAY-ATOMIZER FOR SPRAYABLE MATERIALS.
CH1689774A CH588392A5 (en) 1973-12-26 1974-12-18
AU76710/74A AU481744B2 (en) 1973-12-26 1974-12-20 Spray dispenser for fluent product
ZA00748175A ZA748175B (en) 1973-12-26 1974-12-23 Spray dispenser for fluent product
IT54729/74A IT1026139B (en) 1973-12-26 1974-12-23 SPRAY DISPENSER FOR LIQUID OR POWDER FLUENT PRODUCTS
DK679274AA DK140245B (en) 1973-12-26 1974-12-23 Atomizer.
FR7442499A FR2256085B1 (en) 1973-12-26 1974-12-23
DE2461376A DE2461376C3 (en) 1973-12-26 1974-12-24 Atomizing device for flowable product
ES433297A ES433297A1 (en) 1973-12-26 1974-12-24 Single dose, replaceable supply air pressure operated dispenser
GB55673/74A GB1488920A (en) 1973-12-26 1974-12-24 Spray dispenser for fluent product
CA216,796A CA1010425A (en) 1973-12-26 1974-12-24 Spray dispenser for fluent product
JP49148557A JPS5096908A (en) 1973-12-26 1974-12-26
BE151949A BE823884A (en) 1973-12-26 1974-12-27 AEROSOL DISPENSER FOR FLUID PRODUCTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00427854A US3856185A (en) 1973-12-26 1973-12-26 Single dose, replaceable supply air pressure operated dispenser

Publications (1)

Publication Number Publication Date
US3856185A true US3856185A (en) 1974-12-24

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ID=23696556

Family Applications (1)

Application Number Title Priority Date Filing Date
US00427854A Expired - Lifetime US3856185A (en) 1973-12-26 1973-12-26 Single dose, replaceable supply air pressure operated dispenser

Country Status (14)

Country Link
US (1) US3856185A (en)
JP (1) JPS5096908A (en)
BE (1) BE823884A (en)
CA (1) CA1010425A (en)
CH (1) CH588392A5 (en)
DE (1) DE2461376C3 (en)
DK (1) DK140245B (en)
ES (1) ES433297A1 (en)
FR (1) FR2256085B1 (en)
GB (1) GB1488920A (en)
IT (1) IT1026139B (en)
NL (1) NL7416073A (en)
SE (1) SE407752B (en)
ZA (1) ZA748175B (en)

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US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
US5178513A (en) * 1991-10-08 1993-01-12 Sundstrand Corporation Turbine nozzle phasing device
WO1993012831A1 (en) * 1991-12-20 1993-07-08 Boehringer Ingelheim Kg Powder inhaler using powder carriers with regular surface microfeatures
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
US5307953A (en) * 1991-12-03 1994-05-03 Glaxo Group Limited Single dose dispenser having a piercing member
EP0680348A4 (en) * 1991-08-20 1994-11-28 Habley Medical Technology Corp Timing and velocity controlled powdered pharmaceutical inhaler.
US5547131A (en) * 1992-12-04 1996-08-20 Bespak Plc Dispensing device with spray nozzle and driven piston
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
WO2003072174A1 (en) * 2002-02-28 2003-09-04 Medel S.P.A. Pre-dosed container for a medicinal product and method for its construction
EP1464355A3 (en) * 2003-03-31 2004-12-15 Nathaniel Hughes Medicinal powder delivery system
US20050015051A1 (en) * 2003-05-20 2005-01-20 Peter Stadelhofer Dosing device having a pumping device
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
WO2013033321A1 (en) * 2011-08-30 2013-03-07 Mccormick & Company, Incorporated Particulate sprayer
WO2013150129A1 (en) * 2012-04-05 2013-10-10 Rpc Formatec Gmbh Dispenser for discharging an in particular granular or powdery substance, and method for emptying a substance reservoir
US20130289595A1 (en) * 2012-04-26 2013-10-31 Gyrus Ent, L.L.C. Surgical instrument
US8800550B2 (en) 2001-11-23 2014-08-12 Innovata Biomed Limited Medicament delivery assembly
US20150258960A1 (en) * 2014-03-17 2015-09-17 Joachim Haase Device comprising a gas generator to produce a flow of compressed gas
WO2015193871A1 (en) * 2014-06-16 2015-12-23 MEway Pharma LTD A novel operated nebulizer and means thereof
USD748242S1 (en) * 2014-07-11 2016-01-26 H. Stuart Campbell Inhaler mouthpiece
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
CN108430552A (en) * 2016-01-07 2018-08-21 阿普塔尔法国简易股份公司 Nose powder distribution means
US10071211B2 (en) 2011-01-31 2018-09-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US10207065B2 (en) 2013-07-12 2019-02-19 John H. Silva Mouthpiece for inhalers
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
US10758689B2 (en) 2013-07-03 2020-09-01 Sanara Tech Ltd. Metered dose inhaler and methods thereof
EP3630239A4 (en) * 2017-05-31 2021-05-19 Virginia Commonwealth University DEVICES, SYSTEMS AND METHODS FOR DRY POWDER TREATMENTS
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
EP4371594A4 (en) * 2021-07-16 2025-07-16 Yaowu Ding Device for administering medication by spraying and system for administering medication by spraying using this device

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US2426281A (en) * 1945-08-31 1947-08-26 George W Oakes Head and nasal clarifier
US2519555A (en) * 1945-08-31 1950-08-22 Abbott Lab Sterile medicament insufflator cartridge and insufflator
US3248021A (en) * 1962-11-26 1966-04-26 Calmar Inc Liquid dispenser
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Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5027808A (en) * 1990-10-31 1991-07-02 Tenax Corporation Breath-activated inhalation device
EP0680348A4 (en) * 1991-08-20 1994-11-28 Habley Medical Technology Corp Timing and velocity controlled powdered pharmaceutical inhaler.
US5178513A (en) * 1991-10-08 1993-01-12 Sundstrand Corporation Turbine nozzle phasing device
US5307953A (en) * 1991-12-03 1994-05-03 Glaxo Group Limited Single dose dispenser having a piercing member
WO1993012831A1 (en) * 1991-12-20 1993-07-08 Boehringer Ingelheim Kg Powder inhaler using powder carriers with regular surface microfeatures
US6095134A (en) * 1992-03-06 2000-08-01 The Board Of Regents Of The University Of Co Methods and apparatus for fine particle formation
US5639441A (en) * 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5301664A (en) * 1992-03-06 1994-04-12 Sievers Robert E Methods and apparatus for drug delivery using supercritical solutions
US5547131A (en) * 1992-12-04 1996-08-20 Bespak Plc Dispensing device with spray nozzle and driven piston
US8800550B2 (en) 2001-11-23 2014-08-12 Innovata Biomed Limited Medicament delivery assembly
WO2003072174A1 (en) * 2002-02-28 2003-09-04 Medel S.P.A. Pre-dosed container for a medicinal product and method for its construction
EP1464355A3 (en) * 2003-03-31 2004-12-15 Nathaniel Hughes Medicinal powder delivery system
US8734392B2 (en) 2003-05-20 2014-05-27 Aptar Radolfzell Gmbh Dosing device having a pumping device
US20050015051A1 (en) * 2003-05-20 2005-01-20 Peter Stadelhofer Dosing device having a pumping device
EP1479450A3 (en) * 2003-05-20 2006-02-01 Ing. Erich Pfeiffer GmbH Metering device comprising a single-stroke pump
WO2011013003A2 (en) 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
US10071211B2 (en) 2011-01-31 2018-09-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US9889455B2 (en) * 2011-08-30 2018-02-13 Mccormick & Company, Incorporated Particulate sprayer
WO2013033321A1 (en) * 2011-08-30 2013-03-07 Mccormick & Company, Incorporated Particulate sprayer
US20130056547A1 (en) * 2011-08-30 2013-03-07 Mccormick & Company, Incorporated Particulate sprayer
US12041968B2 (en) 2011-09-06 2024-07-23 Nicoventures Trading Limited Heating smokeable material
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
US9375738B2 (en) 2012-04-05 2016-06-28 Rpc Formatec Gmbh Dispenser for discharging an in particular granular or powdery substance, use of a sucking/blowing dispenser, and method for emptying a substance reservoir
WO2013150129A1 (en) * 2012-04-05 2013-10-10 Rpc Formatec Gmbh Dispenser for discharging an in particular granular or powdery substance, and method for emptying a substance reservoir
US20130289595A1 (en) * 2012-04-26 2013-10-31 Gyrus Ent, L.L.C. Surgical instrument
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
US10758689B2 (en) 2013-07-03 2020-09-01 Sanara Tech Ltd. Metered dose inhaler and methods thereof
US10207065B2 (en) 2013-07-12 2019-02-19 John H. Silva Mouthpiece for inhalers
US20150258960A1 (en) * 2014-03-17 2015-09-17 Joachim Haase Device comprising a gas generator to produce a flow of compressed gas
US11020542B2 (en) 2014-06-16 2021-06-01 Sanara Tech Ltd. Operated nebulizer and means thereof
WO2015193871A1 (en) * 2014-06-16 2015-12-23 MEway Pharma LTD A novel operated nebulizer and means thereof
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
USD748242S1 (en) * 2014-07-11 2016-01-26 H. Stuart Campbell Inhaler mouthpiece
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US12016393B2 (en) 2015-10-30 2024-06-25 Nicoventures Trading Limited Apparatus for heating smokable material
US12219986B2 (en) 2015-10-30 2025-02-11 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
CN108430552B (en) * 2016-01-07 2020-07-31 阿普塔尔法国简易股份公司 nasal powder dispensing device
CN108430552A (en) * 2016-01-07 2018-08-21 阿普塔尔法国简易股份公司 Nose powder distribution means
EP3630239A4 (en) * 2017-05-31 2021-05-19 Virginia Commonwealth University DEVICES, SYSTEMS AND METHODS FOR DRY POWDER TREATMENTS
US11690964B2 (en) 2017-05-31 2023-07-04 Virginia Commonwealth University Devices, systems, and methods for dry powder therapies
US12521500B2 (en) 2017-05-31 2026-01-13 Virginia Commonwealth University Devices, systems, and methods for dry powder therapies
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US12102754B2 (en) 2017-09-26 2024-10-01 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
EP4371594A4 (en) * 2021-07-16 2025-07-16 Yaowu Ding Device for administering medication by spraying and system for administering medication by spraying using this device

Also Published As

Publication number Publication date
DE2461376A1 (en) 1975-07-10
SE7415242L (en) 1975-06-27
DE2461376C3 (en) 1978-04-20
DE2461376B2 (en) 1977-08-25
SE407752B (en) 1979-04-23
IT1026139B (en) 1978-09-20
GB1488920A (en) 1977-10-19
ZA748175B (en) 1976-01-28
FR2256085A1 (en) 1975-07-25
FR2256085B1 (en) 1977-05-20
JPS5096908A (en) 1975-08-01
BE823884A (en) 1975-06-27
DK679274A (en) 1975-09-08
CA1010425A (en) 1977-05-17
ES433297A1 (en) 1976-12-01
AU7671074A (en) 1976-06-24
CH588392A5 (en) 1977-05-31
DK140245C (en) 1979-12-24
NL7416073A (en) 1975-06-30
DK140245B (en) 1979-07-16

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