US3838065A - Standard solution of glycerol - Google Patents

Standard solution of glycerol Download PDF

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Publication number
US3838065A
US3838065A US00279116A US27911672A US3838065A US 3838065 A US3838065 A US 3838065A US 00279116 A US00279116 A US 00279116A US 27911672 A US27911672 A US 27911672A US 3838065 A US3838065 A US 3838065A
Authority
US
United States
Prior art keywords
glycerol
standard solution
solution
standard
perchloric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00279116A
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English (en)
Inventor
W Lippert
E Bernt
W Gruber
H Bergmeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of US3838065A publication Critical patent/US3838065A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Definitions

  • the present invention is concerned with a glycerol standard solution and a method for the monitoring and control of glycerol determinations using such a solution.
  • glycerol is stabilized to an outstanding extent by dilute perchloric acid solutions so that, even after storage for several months, no changes in the glycerol content of the standard glycerol solutons occur.
  • a glycerol standard solution which consists of a solution of glycerol in 0.02 to 0.2 N perchloric acid, the solvent preferably consisting of approximately 0.05 N perchloric acid.
  • the glycerol content is itself not critical but the solution is preferably sufficiently dilute in order to insure 3,838,065 Patented Sept. 24, 1974 exact measurement thereof. From this point of view, the preferred glycerol concentration is between about 1 mg./ ml. and 50 mg./ 100 ml. and is more preferably about 10 mg./l00 ml.
  • the stabilizing action of the dilute perchloric acid ascertained according to the present invention is surprising because substances known to be outstanding stabilizing or preserving agents, such as sodium azide, have proved to be useless.
  • the glycerol content When using a sodium azide solution, the glycerol content has already dropped after four weeks to such an extent that it can no longer be used as a standard solution and after ten Weeks storage, the glycerol content has, under these conditions, already decreased to about one half of the initial content.
  • a glycerol standard solution consisting essentially of a solution of glycerol in 0.02 to 0.2 N perchloric acid, wherein the glycerol is present in an amount of from about 1 to 50 mg./100 ml.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sampling And Sample Adjustment (AREA)
US00279116A 1971-09-10 1972-08-09 Standard solution of glycerol Expired - Lifetime US3838065A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2145346A DE2145346C3 (de) 1971-09-10 1971-09-10 Glycerin-Standardlösung

Publications (1)

Publication Number Publication Date
US3838065A true US3838065A (en) 1974-09-24

Family

ID=5819222

Family Applications (1)

Application Number Title Priority Date Filing Date
US00279116A Expired - Lifetime US3838065A (en) 1971-09-10 1972-08-09 Standard solution of glycerol

Country Status (8)

Country Link
US (1) US3838065A (OSRAM)
JP (1) JPS5327954B2 (OSRAM)
CH (1) CH565127A5 (OSRAM)
DE (1) DE2145346C3 (OSRAM)
FR (1) FR2152224A5 (OSRAM)
GB (1) GB1345495A (OSRAM)
IT (1) IT962412B (OSRAM)
NL (1) NL168335C (OSRAM)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891573A (en) * 1973-05-14 1975-06-24 Boehringer Mannheim Gmbh Aqueous cholesterol standard solution
US4405817A (en) * 1981-04-30 1983-09-20 The B. F. Goodrich Company Stabilized hydroxyl terminated reactive liquid polymers
US20110185893A1 (en) * 2008-03-20 2011-08-04 Donaldson Company, Inc. Evacuation Valve Arrangements; Pulse Jet Air Cleaner Systems Using Same; and, Methods
US9186612B2 (en) 2010-01-22 2015-11-17 Donaldson Company, Inc. Pulse jet air cleaner systems; evacuation valve arrangements; air cleaner components; and, methods

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5778808U (OSRAM) * 1980-10-31 1982-05-15

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3891573A (en) * 1973-05-14 1975-06-24 Boehringer Mannheim Gmbh Aqueous cholesterol standard solution
US4405817A (en) * 1981-04-30 1983-09-20 The B. F. Goodrich Company Stabilized hydroxyl terminated reactive liquid polymers
US20110185893A1 (en) * 2008-03-20 2011-08-04 Donaldson Company, Inc. Evacuation Valve Arrangements; Pulse Jet Air Cleaner Systems Using Same; and, Methods
US8262762B2 (en) 2008-03-20 2012-09-11 Donaldson Company, Inc. Evacuation valve arrangements; pulse jet air cleaner systems using same; and, methods
US9186612B2 (en) 2010-01-22 2015-11-17 Donaldson Company, Inc. Pulse jet air cleaner systems; evacuation valve arrangements; air cleaner components; and, methods
US10675578B2 (en) 2010-01-22 2020-06-09 Donaldson Company, Inc. Pulse jet air cleaner systems; evacuation valve arrangements; air cleaner components; and, methods
US11826691B2 (en) 2010-01-22 2023-11-28 Donaldson Company, Inc. Pulse jet air cleaner systems; evacuation valve arrangements; air cleaner components; and, methods

Also Published As

Publication number Publication date
DE2145346A1 (de) 1973-04-19
GB1345495A (en) 1974-01-30
CH565127A5 (OSRAM) 1975-08-15
DE2145346C3 (de) 1978-03-09
NL168335B (nl) 1981-10-16
DE2145346B2 (de) 1977-07-14
NL168335C (nl) 1982-03-16
JPS5327954B2 (OSRAM) 1978-08-11
JPS4838192A (OSRAM) 1973-06-05
NL7210699A (OSRAM) 1973-03-13
IT962412B (it) 1973-12-20
FR2152224A5 (OSRAM) 1973-04-20

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