US3827305A - Adjustable pipette - Google Patents
Adjustable pipette Download PDFInfo
- Publication number
- US3827305A US3827305A US00300215A US30021572A US3827305A US 3827305 A US3827305 A US 3827305A US 00300215 A US00300215 A US 00300215A US 30021572 A US30021572 A US 30021572A US 3827305 A US3827305 A US 3827305A
- Authority
- US
- United States
- Prior art keywords
- shaft
- plunger
- pipette
- overtravel
- stop
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000007789 sealing Methods 0.000 claims abstract description 7
- 229920003023 plastic Polymers 0.000 claims description 6
- 230000004044 response Effects 0.000 claims description 5
- 239000000523 sample Substances 0.000 description 16
- 210000003813 thumb Anatomy 0.000 description 9
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000000994 depressogenic effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- 210000005224 forefinger Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 description 1
- 241001237728 Precis Species 0.000 description 1
- 241000231739 Rutilus rutilus Species 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 244000299492 Thespesia populnea Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
- B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
- B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/025—Displaying results or values with integrated means
- B01L2300/026—Drum counters
Definitions
- An adjustable pipette includes an elongated body de- R0136" Gllson, 4 Franklin fining a barrel portion and a plunger cavity.
- a plunger both of Madlson, 53705 unit is mounted for reciprocation in the body and in- [22]
- Filed: Oct 24 1972 cludes a plunger portion extending from the barrel portion into the plunger cavity, and further includes PP 300,215 an operating portion extending rearwardly out of the body.
- the plunger unit includes a stop disposed within 52 11.s.c1.
- a forward stop for [56] References Cited movelment of the plungierbunirt is provided by an ogertrave mem er enga e yt e unger sto mem er.
- UNITED STATES PATENTS Travel of the plung r unit past the forwafd position 2,530,909 ll/l950 R1ggs 222/309 X compresses an overtrave] Spring, and a Sea] assembly a i 'figzi 43 2 is compressed by the overtravel spring into sealing en- 3'49s135 3 1970 mallz et al.
- a primary disadvantage is that such devices are not capable of providing samples of continuously variable size. At the most, presently available devices are adjustable by the user between two or a few discrete volumes. In addition, no clear indication is provided of the volume setting, and this can result in errors or at least inconvenience in use.
- an adjustable pipette constructed in accordance with the present invention includes an elongated body defining a barrel portion and defining a plunger cavity adjacent the forward end of the body.
- a plunger unit is mounted for reciprocation in the body and includes a plunger portion extending from the barrel portion of the body into the plunger cavity, together with an operating portion extending rearwardly out of the body.
- a seal assembly is carried by the body and seals against the plunger portion.
- the plunger unit includes a stop engaging member mounted on the plunger unit and disposed within the barrel portion of the body. A forward stop in the body is engaged by the stop engaging member upon forward movement of the plunger unit to a forward stop position.
- a hollow threaded shaft engages a nut fixed in the body and includes a forward end disposed within the barrel portion of the body and a rear end extending rearwardly out of the body.
- a rear stop is associated with the forward end of the threaded shaft and is engaged by the plunger unit stop engaging means upon rearward movement of the plunger unit to a rear position.
- An indicator arrangement mounted with the body is keyed to the shaft for providing an indication in response to rotation of the shaft indicative of the position of the rear stop and thus of the sample size.
- FIG. 1 is a partly sectional side view of an adjustable pipette embodying the features of the present invention
- FIG. 2 is an enlarged, fragmentary sectional view of the adjustable pipette of FIG. 1 taken along the line 2-2 of FIG. 1;
- FIG. 3 is an end view of the adjustable pipette partly taken in section along the line 3-3 of FIG. 2;
- FIG. 4 is an exploded, fragmentary perspective view of parts of the seal assembly of the adjustable pipette.
- the pipette 10 includes a body designated as a whole by the reference numeral 12 within which there is reciprocably supported a plunger unit 14.
- a novel seal assembly generally designated as 16 providing an air tight seal between the body 12 and the plunger unit 14.
- a volume adjustment assembly generally designated as 18 functions in accordance with another feature of the invention to permit reliable and accurate smallincrement volume adjustments, and volume settings are clearly indicated in accurate fashion by a volume indicator assembly generally designated as 20.
- the body 12 includes a main housing 22 together with a nose member 24.
- the main housing 22 defines a generally cylindrical barrel portion 26 and an enlarged cavity 28 for enclosing the volume indicator assembly 20.
- the rear end of the main housing 22 is closed by a cap 30.
- the cap may be attached in any suitable manner, and preferably is snapped into place by a protuberance and notch arrangement 32 (FIG. 2).
- the nose member 24 is mounted to the main housing 22 by means of a nut 34 threaded onto the forward end of the main housing 22 over the barrel portion 26.
- the nose member 24 includes an enlarged rearward end section 36 defining an overtravel chamber 38.
- a mounting rib 40 is held firmly against the forward end of the main housing 22 by a flange 42 of nut 34, and a spring retainer 44 is captured between the rearward end of the nose member 24 and a shoulder 46 defined by a counterbore in the forward end of the barrel portion 26 of the main housing 22.
- the nose member 24 includes an elongated section 48 defining a plunger cavity 50.
- the forward end of the nose member 24 is provided with frictionally mounted, tapered tip members such as the member 52 illustrated in FIG. 1.
- An opening 54 in the nose member 24 provides communication between the interior of the tip 52 and the plunger cavity 50.
- the interior of the tip 52 is preferably large enough so that entire samples may be held therein without contact with the nose member 24, and preferably the tip member 52 is made of suitable non-wetting plastic material to facilitate complete discharge of samples.
- the overall size and configuration of the adjustable pipette 10 are such as to facilitate its use.
- the slender configuration permits insertion of the nose member 24 into narrow receptacles.
- the adjustable pipette 10 can readily be held in the hand, and the main housing 22 is provided with a trigger guard-type finger handle 56 having a generally C-shape or D-shape and substantially completely encircling the forefinger of a hand grasping the main housing 22.
- the arrangement is such that in use the adjustable pipette can be held suspended upon a forefinger by the finger handle 56 in position naturally to be grasped by the hand with the thumb in position for use over the rearward end of the pipette 10.
- the plunger unit 14 includes a circular cylindrical plunger portion 60 having a forward end extending into the plunger cavity 50 defined within the nose member 24. Extending rearwardly from the plunger portion 60, and preferably integral therewith, is an operating rod portion 62 terminating well outside of the rearward end of the body 12. A thumb button 64 is attached to the outer end of the operating rod portion 62 by a screw retainer 66.
- the plunger unit 14 In its rest position the plunger unit 14 is urged rearwardly by a spring 67 (FIG. 2) against an adjustable rear stop, described hereinafter and comprising part of the volume adjustment assembly 18.
- the spring 67 is held in compression within the barrel portion 26 of the housing 22 between the spring retainer 44 and a spring retainer and stop member 68.
- the member 68 is located over a shoulder 70 between the plunger portion 60 and operating rod portion 62 of the plunger unit '14, and is press fit to the plunger portion 60 or is otherwise permanently attached to form part of the plunger unit 14.
- Member 68 is provided with a rearwardly facing stop surface 72 held against the adjustable rear stop in the rest position of the plunger.
- the thumb button 64 is depressed to move the plunger unit 14 forward. This movement is accommodated by compression of spring 67.
- Member 68 includes an elongated small diameter forward end portion 74 comprising a forward stop surface. Forward movement of the plunger unit 14 results in movement of stop portion 74 through a central opening 76 in spring retainer 44 until it strikes a forward stop and overtravel member 78 mounted in the overtravel chamber 38 against the forward side of spring retainer 44. In this position, the plunger portion 60 of the plunger unit 14 is extended into the plunger cavity 50. Tip member 52 is immersed in a sample material, and the thumb button 64 is released.
- Plunger unit 14 is moved rearwardly by the force stored in spring 67 to retract the plunger portion 60 in the plunger cavity 50, and suction within the plunger cavity 50 communicated to the interior of the tip member 52 draws a sample of predetermined size into the tip member 52.
- the thumb button 64 is once again depressed to move the plunger unit 14 in a forward direction.
- the member 68 again moves forwardly until surface 74 contacts the forward stop and overtravel member 78.
- This member is held in the position illustrated in FIG. 2 by means of an overtravel spring 80 held in compression between the forward side of member 78 and the rearward side of a spring retainer and pressure member 82 disposed at the forward end of the overtravel chamber 38.
- the plunger unit 14 is moved through an overtravel movement wherein the forward stop portion 74 of the member 68 drives the forward stop and overtravel member 78 against the force of the spring 80 into the overtravel chamber 38.
- the plunger portion 14 moves further into the overtravel chamber 50 during the discharge stroke than during the intake stroke.
- the spring 80 is preferably substantially stiffer than the spring 67.
- the seal assembly 16 of novel construction provides a reliable, airtight, low friction seal between the body 12 and the plunger unit 14. Moreover, seal assembly 16 is spring loaded by over-travel spring 80 and thus spring 80 performs a dual function.
- the seal assembly 16 includes a toric seal member 86 disposed within a counterbore cavity 88 in the forward end of the spring retainer and pressure member 82.
- Seal member 86 includes a cylindrical collar portion 90 intimately encircling the plunger portion 60 and a flange section 92 engaged by the member 82.
- a resilient O- ring 94 is held around the collar 90 between the flange 92 of the seal member and the forward wall of the overtravel cavity 38.
- the size of the O-ring 94 relative to the size of the toric seal member 86 and cavity 88 is such that the O-ring 94 is somewhat compressed by the force of the spring 80.
- the toric seal member is of somewhat soft and flexible plastic material, and the cylindrical collar portion 90 of the seal member 88 is resiliently forced by the spring loaded O-ring 94 inwardly into sealing relation with the plunger portion 60.
- the use of a smooth metal plunger unit 14 and of a flexible plastic seal member 86 assures not only a good seal, but also very low sliding friction during reciprocation of the plunger unit 14.
- the volume adjustment assembly 18 provided in accordance with the present invention includes a hollow threaded shaft having an inner end disposed within the barrel portion 26 of the housing 22 and having an outer end spaced outwardly of the cap 30.
- the shaft 100 is received in an internally threaded nut member 102 fixed against rotational and longitudinal movement by means of a locking pin 104.
- Nut 102 is received in the rearward end of the barrel portion 26 and includes a flange 106 received in the forward end of the enlarged cavity 28.
- a retaining nut 108 is threaded onto the innermost end of the shaft 100 and is then looked in place, as by deformation. The purpose of the retaining nut 108 is to prevent the shaft 100 from being inadvertently withdrawn through the nut member 102.
- Rotation of the shaft 100 is facilitated by the provision of a knurled head or cap 110 threaded over the outer end of the shaft 100 and locked into position by means of a pair of screw retainers 112.
- Slidably received over the operating rod portion 62 of the plunger unit 14 within the hollow threaded shaft 100 is an inner sleeve or shaft 114.
- the purpose of sleeve 114 is to permit adjustment of the volume indicator assembly 20 in relation to the volume adjustment assembly 18.
- the forward end of the sleeve 114 designated by the reference numeral 116, extends slightly beyond the forward end of the threaded shaft 100 and forms the forwardmost part of the volume adjustment assembly 18.
- the forward end 116 of sleeve 114 is engaged by the stop surface 72 of the member 68 and provides the rearward stop for motion of the plunger unit 14.
- Adjustment of the sample volume of pipette is accomplished by rotation of the head 110 resulting in reciprocation of the threaded shaft 100 and of the sleeve 114 due to threaded engagement with the nut member 102. This reciprocation moves the rearward stop 116 toward and away from the forward stop 78 thus adjusting the stroke of the plunger member 14 and the volume of a sample.
- the volume adjustment assembly 18 also includes provision for locking the unit in position for any desired sample size.
- a locking ring 118 threaded upon the shaft 100 to the rear of the cap 30 of the main housing 22. Once the shaft has been rotated to position it in the desired longitudinal position, the locking ring 118 is threaded inwardly firmly against the cap 30 thus locking the shaft 100 against further rotation.
- a retaining pin 120 extending outwardly from cap 30 into a circular groove 122 in the underside of locking ring 118. If an attempt is made to unscrew the locking ring 118 away from the cap 30, the retaining pin 120 is engaged as illustrated in FIGS. 2 and 3 by a stop pin 124 extending across the groove 122 in a radial direction. The arrangement is such that rotation of the locking ring 118 in the opposite direction away from the position illustrated in FIG. 3 will result in tightening of the ring 118 against the cap 30 in less than a full revolution.
- the volume indicator assembly provides an exact and easily perceived readout of the volume setting of the volume adjustment assembly 18.
- a series of indicator rings 130, 132 and 134 Arranged in stacked relationship within the enlarged cavity 28 between cap and flange 106 are a series of indicator rings 130, 132 and 134, each encircling the adjustment shaft 100.
- the rings 130, 132 and 134 express the volume setting in units, tens and hundreds, respectively, of microliters. It will be understood that fewer or more rings graduated in any desired units may be provided.
- the threaded shaft 100 includes a groove 136 extending throughout its length.
- the units ring includes an inwardly extending projection 138 received in the groove 136 to the end that the ring 130 rotates with the shaft 100 but permits the shaft 100 to move longitudinally relative to the ring.
- the tens ring 132 and the hundreds ring 134 are free for relative rotation independent of the threaded shaft 100.
- a transparent window 154 for viewing of the indicator rings 130, 132 and 134.
- the entire main housing 22 is formed of clear plastic with the window area 154 being polished for clear visibility. Any other window structure may be used if desired.
- Each of the rings 130, 132 and 134 is provided with numerical indicia, and if desired the units ring 130 may be provided with fractional graduations registering with an index line 156 on the window 154.
- the rings 130, 132 and 134 are mounted so that a zero indication appears when the shaft 100 is threaded inwardly approximately until the stop portion 74 is in contact with the forward stop 78 in its rearward position.
- the funtion of the slleeve 114 comes into play.
- the head 110 is rotated until the indicator assembly 20 provides precisely at zero indication. At this point the screw retainers 112 are loosened and the head 110 can be rotated while the shaft 100 remains stationary. During such rotation the reading of the indicator 20 is not changed.
- the pipette 10 is first adjusted through manipulation of the volume adjustment assembly 18 to the desired volume. This is accomplished by rotation of the head 110 to cause reciprocation of the shaft 100 thus setting the position of the rear stop 116.
- the locking ring 118 is rotated firmly against the cap 30 in order to prevent further inadvertent rotation of the shaft 100.
- the thumb button 64 is depressed to drive the plunger portion 60 of the plunger unit 14 forwardly into the plunger cavity 50 through a precisely predetermined distance until the stop portion 74 strikes the forward stop 78. Inadvertent overtravel is avoided due to the stiffness of the overtravel spring 80. At this point the tip member 52 is immersed in a sample material and the thumb button 64 is retracted to draw up the sample.
- the sample is discharged by once again depressing the thumb button 64 to move the plunger portion 60 into the plunger cavity 50.
- the plunger unit 14 is moved into the overtravel range by forcing the forward stop and overtravel member 78 forwardly into the overtravel chamber 38 against the force of the stiff spring 80. This overtravel movement assures complete discharge of the sample.
- the thumb button 64 is released, the plunger unit 14 re turns to its rest position with the surface 72 against the rear stop 116.
- An adjustable pipette comprising in combination;
- an elongated body defining a barrel portion and defining a plunger cavity adjacent the forward end of said body
- a plunger unit mounted for reciprocation in said body and including a plunger portion extending from said barre-l portion into said plunger cavity and an operating portion extending rearwardly out of said body;
- first biasing means in said barrel portion urging said plunger unit in a rearward direction
- said body defining an overtravel chamber disposed between said barrel portion and said plunger cavy;
- said plunger unit including a stop engaging member permanently mounted thereon and disposed within said barrel portion;
- an overtravel member mounted for movement in said overtravel chamber and having a forward stop surface engageable by said stop engaging member upon forward reciprocation of said plunger unit to a forward stop position;
- rear stop means reciprocal with the forward end of said shaft upon rotation of said shaft in said nut and engageable by said stop engaging member upon rearward reciprocation of said plunger unit to a rear stop position;
- indicator means in said body coupled to said shaft for providing an indication in response to rotation of said shaft indicative of the position of said rear stop means.
- said seal assembly including a retainer member pressed by said second biasing means toward said forward wall and having an axial central opening receiving said plunger portion, a counterbore cavity in the forward side of said retainer member cooperating with said forward wall to define an annular chamber surrounding said plunger portion, and compressible sea] means in said annular chamber.
- said compressible sealing means including a flexible cylindrical collar surrounding said plunger portion, and an O-ring surrounding said collar, said O-ring being sized to deform when compressed by said second biasing means to force said collar inwardly against said plunger portion.
- the pipette of claim 6 including retaining means on said body and on said locking member for preventing rotation of said locking member through a complete revolution from the locking position.
- said indicator means including a plurality of indicator rings encircling said threaded shaft within said body, indicia on said indicator rings, a window means in said body for viewing of said indicia, one said ring being coupled to said threaded shaft for rotation therewith while permitting reciprocal movement of said shaft through said rings, and drive means coupled between said rings for controlling the relative movement thereof in response to rotation of said shaft.
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- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00300215A US3827305A (en) | 1972-10-24 | 1972-10-24 | Adjustable pipette |
GB3572473A GB1439659A (en) | 1972-10-24 | 1973-07-26 | Adjustable pipette removal of catalyst from a moving-bed process for hte hydro processing of heavy hydrocarbon charge stocks |
FR7332978A FR2203680B1 (US20100170793A1-20100708-C00006.png) | 1972-10-24 | 1973-09-13 | |
JP11884573A JPS5713338B2 (US20100170793A1-20100708-C00006.png) | 1972-10-24 | 1973-10-22 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US00300215A US3827305A (en) | 1972-10-24 | 1972-10-24 | Adjustable pipette |
Publications (1)
Publication Number | Publication Date |
---|---|
US3827305A true US3827305A (en) | 1974-08-06 |
Family
ID=23158177
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00300215A Expired - Lifetime US3827305A (en) | 1972-10-24 | 1972-10-24 | Adjustable pipette |
Country Status (4)
Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4096751A (en) * | 1977-06-15 | 1978-06-27 | Oxford Laboratories Inc. | Hand-held micropipettor with fluid transfer volume adjustment mechanism |
US4096750A (en) * | 1977-06-15 | 1978-06-27 | Oxford Laboratories Inc. | Hand-held micropipettor with fluid transfer volume adjustment mechanism |
DE2825015A1 (de) | 1977-06-15 | 1978-12-21 | Oxford Lab | Fluessigkeitsuebertragungsgeraet |
US4159784A (en) * | 1976-08-18 | 1979-07-03 | Marteau D Autry Eric | Device for dispensing adjustable volumes of a liquid |
US4229413A (en) * | 1977-04-27 | 1980-10-21 | Marteau D Autry Eric | Adjustable device for distributing liquid samples |
US4263257A (en) * | 1978-09-08 | 1981-04-21 | Metsaele Seppo Juhani | Pipette |
US4362063A (en) * | 1980-01-04 | 1982-12-07 | Marteau D Autry Eric | Device for sampling and dispensing adjustable volumes of liquid, with numerical display |
US4369665A (en) * | 1978-01-11 | 1983-01-25 | Indicon Inc. | Manually holdable automatic pipette |
US4395921A (en) * | 1981-06-26 | 1983-08-02 | Scientific Manufacturing Industries, Inc. | Adjustable volume liquid dispenser |
US4442722A (en) * | 1982-02-23 | 1984-04-17 | Beckman Instruments Inc. | Plunger operated pipet |
US4554134A (en) * | 1982-06-29 | 1985-11-19 | Labsystems Oy | Pipette with adjustable volume |
US4567780A (en) * | 1984-03-12 | 1986-02-04 | American Hospital Supply Corporation | Hand-held pipette with disposable capillary |
USRE32210E (en) * | 1974-10-15 | 1986-07-22 | Device for ejecting the removable tip of a pipette | |
US4672857A (en) * | 1985-09-10 | 1987-06-16 | Labindustries, Inc. | Liquid microdispenser |
US4679446A (en) * | 1985-09-09 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Multi-volume displacement pipette |
US4824642A (en) * | 1986-10-21 | 1989-04-25 | Costar Corporation | Multi-channel pipetter |
US5012682A (en) * | 1988-10-21 | 1991-05-07 | Firma Eppendorf-Netheler-Hinz Gmbh | Pipetting device |
US5104624A (en) * | 1989-10-20 | 1992-04-14 | Costar Corporation | Pipetter |
US5253785A (en) * | 1992-04-02 | 1993-10-19 | Habley Medical Technology Corp. | Variable proportion dispenser |
WO1994003222A2 (en) * | 1992-07-31 | 1994-02-17 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
US5320810A (en) * | 1992-05-13 | 1994-06-14 | Integrated Instrument Services, Inc. | Pipette with an axially stationary volume adjusting wheel |
US5364595A (en) * | 1993-07-02 | 1994-11-15 | Porex Technologies Corp. | Pipette device constructed to prevent contamination by aerosols or overpipetting |
US5531131A (en) * | 1993-10-21 | 1996-07-02 | Eppendorf-Netheler-Hinz Gmbh | Device for adjusting correction factor of a plunger lift pipet |
US5650124A (en) * | 1995-07-24 | 1997-07-22 | Gilson; Warren E. | Adjustable pipette |
EP0787040A2 (en) * | 1995-07-14 | 1997-08-06 | Rainin Instrument Co.,Inc. | Manual pipette with magnet assist |
WO1997032666A1 (en) * | 1996-03-05 | 1997-09-12 | Rainin Instrument Co., Inc. | Manual pipette with delayed-action home position latch |
US5804144A (en) * | 1993-04-21 | 1998-09-08 | Labsystems Oy | Piston pipette |
US5849248A (en) * | 1996-03-05 | 1998-12-15 | Rainin Instrument Co., Inc. | Adjustable volume pipette with improved volume adjustment lock mechanism |
US6158292A (en) * | 1996-11-04 | 2000-12-12 | Gilson; Warren E. | Pipette |
US6232129B1 (en) | 1999-02-03 | 2001-05-15 | Peter Wiktor | Piezoelectric pipetting device |
US6295880B1 (en) | 1999-12-08 | 2001-10-02 | Warren E. Gilson | Adjustable pipette |
FR2807345A1 (fr) * | 2000-04-07 | 2001-10-12 | Gilson Sa | Pipette de prelevement a demontage simplifie |
FR2807343A1 (fr) * | 2000-04-07 | 2001-10-12 | Gilson Sa | Pipette de prelevement munie de moyens de reglage du volume a prelever |
WO2003033151A1 (en) * | 2001-10-16 | 2003-04-24 | Matrix Technologies Corporation | Hand-held pipettor |
US20040031334A1 (en) * | 2002-08-17 | 2004-02-19 | Sven Bulow | Pipetting device |
WO2005065360A2 (en) | 2003-12-31 | 2005-07-21 | Rainin Instrument, Llc | Volume adjustable manual pipette with quick set volume adjustment |
US6926867B1 (en) * | 2001-10-30 | 2005-08-09 | World Precision Instruments, Inc. | Pipette piston seal assembly |
US20050262951A1 (en) * | 2004-05-27 | 2005-12-01 | Richard Cote | Hand held pipette |
US20060027033A1 (en) * | 2002-10-16 | 2006-02-09 | Richard Cote | Hand-held pipette employing voice recognition control |
US20060096349A1 (en) * | 2002-08-27 | 2006-05-11 | Andrzej Czernecki | Method of pipette calibration |
EP1743701A1 (de) * | 2005-07-16 | 2007-01-17 | Eppendorf Ag | Kolbenhubpipette |
US20080260592A1 (en) * | 2007-04-23 | 2008-10-23 | Zhenggang Yang | Discretely Adjustable Pipettor |
US20090000351A1 (en) * | 2007-06-29 | 2009-01-01 | Rainin Instrument LLC | Hybrid manual-electronic pipette |
EP2452752A1 (en) * | 2010-11-11 | 2012-05-16 | Thermo Fisher Scientific Oy | Handle pipette |
WO2012069925A1 (en) | 2010-11-23 | 2012-05-31 | Andrew Alliance S.A | Devices and methods for programmable manipulation of pipettes |
US20130023790A1 (en) * | 2011-07-19 | 2013-01-24 | Schaeffer Jeremy R | Biopsy device |
US20130078736A1 (en) * | 2011-09-23 | 2013-03-28 | Simon Roderick Grover | System and apparatus for reactions |
EP2452753A3 (en) * | 2010-11-11 | 2013-05-08 | Thermo Fisher Scientific Oy | Support pipette |
DE102012003846A1 (de) | 2012-02-29 | 2013-08-29 | Eppendorf Ag | Pipette |
EP2659978A1 (de) | 2012-05-02 | 2013-11-06 | Eppendorf AG | Pipette mit Verriegelungssystem |
US20140242719A1 (en) * | 2011-10-20 | 2014-08-28 | Thermo Fisher Scientific Oy | Pipette With Piston Rotation Lock |
US20150000427A1 (en) * | 2013-06-27 | 2015-01-01 | Welker, Inc. | Volumetric sample adjustment assembly located outside a liquid process line |
US9044749B2 (en) | 2012-02-29 | 2015-06-02 | Eppendorf Ag | Pipette |
WO2015092777A3 (en) * | 2013-12-22 | 2015-11-12 | Indian Institute Of Science Education And Research-Mohali | A semi-automatic pipette filler instrument and a modified pipette |
US9295986B2 (en) | 2012-05-02 | 2016-03-29 | Eppendorf Ag | Pipette with releasable locking of rotational position of actuating element |
WO2019060331A1 (en) * | 2017-09-19 | 2019-03-28 | Mettler-Toledo Rainin, LLC | QUICK ADJUSTMENT PIPETTE VOLUME ADJUSTMENT MECHANISM |
US10551240B2 (en) | 2017-11-28 | 2020-02-04 | International Business Machines Corporation | Self-cleaning liquid level sensor |
US10744498B2 (en) | 2017-09-19 | 2020-08-18 | Mettler-Toledo Rainin, LLC | Pipette quickset volume adjustment mechanism |
US10751712B2 (en) | 2017-09-19 | 2020-08-25 | Mettler-Toledo Rainan, LLC | Pipette quickset volume adjustment mechanism |
US11802871B2 (en) * | 2017-07-21 | 2023-10-31 | Helena Laboratories Corporation | System and method for depositing antisera in immunofixation electrophoresis |
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US4099548A (en) * | 1976-08-25 | 1978-07-11 | Oxford Laboratories Inc. | Hand-held pipette for repetitively dispensing precise volumes of liquid |
US4098125A (en) * | 1977-03-30 | 1978-07-04 | Lee Thomas E | Adjustable volume pipetting device |
FR2432161A1 (fr) * | 1978-07-24 | 1980-02-22 | Marteau D Autry Eric | Pipette reglable de distribution a repetition de solutions ou de suspensions |
US4165646A (en) * | 1978-07-26 | 1979-08-28 | Shapiro Justin J | Adjustable micro-dispensing liquid pipet |
DE3204178C2 (de) * | 1982-02-06 | 1986-03-20 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | Pipettiervorrichtung |
US5018394A (en) * | 1990-01-10 | 1991-05-28 | Gilson Warren E | Continuously adjustable diluting device for mixing predetermined volumes of liquid |
FR2696110B1 (fr) * | 1992-09-28 | 1994-12-09 | Gilson Medical Electronics Sa | Perfectionnement à une piquette de prélèvement et de distribution de volumes réglables de liquides. |
FR2986718B1 (fr) * | 2012-02-13 | 2014-03-28 | Gilson Sas | Pipette de prelevement permettant de detecter, de maniere simplifiee, le passage du piston par une position predeterminee |
FR3010518A1 (fr) * | 2013-09-12 | 2015-03-13 | Gilson Sas | Pipette de prelevement presentant un dispositif ameliore de reglage et d'affichage d'un volume a prelever |
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USRE32210E (en) * | 1974-10-15 | 1986-07-22 | Device for ejecting the removable tip of a pipette | |
US4159784A (en) * | 1976-08-18 | 1979-07-03 | Marteau D Autry Eric | Device for dispensing adjustable volumes of a liquid |
US4229413A (en) * | 1977-04-27 | 1980-10-21 | Marteau D Autry Eric | Adjustable device for distributing liquid samples |
US4096750A (en) * | 1977-06-15 | 1978-06-27 | Oxford Laboratories Inc. | Hand-held micropipettor with fluid transfer volume adjustment mechanism |
DE2825015A1 (de) | 1977-06-15 | 1978-12-21 | Oxford Lab | Fluessigkeitsuebertragungsgeraet |
US4096751A (en) * | 1977-06-15 | 1978-06-27 | Oxford Laboratories Inc. | Hand-held micropipettor with fluid transfer volume adjustment mechanism |
DE2857423C2 (US20100170793A1-20100708-C00006.png) * | 1977-06-15 | 1989-04-27 | Sherwood Medical Co., St. Louis, Mo., Us | |
US4369665A (en) * | 1978-01-11 | 1983-01-25 | Indicon Inc. | Manually holdable automatic pipette |
US4263257A (en) * | 1978-09-08 | 1981-04-21 | Metsaele Seppo Juhani | Pipette |
US4362063A (en) * | 1980-01-04 | 1982-12-07 | Marteau D Autry Eric | Device for sampling and dispensing adjustable volumes of liquid, with numerical display |
US4395921A (en) * | 1981-06-26 | 1983-08-02 | Scientific Manufacturing Industries, Inc. | Adjustable volume liquid dispenser |
US4442722A (en) * | 1982-02-23 | 1984-04-17 | Beckman Instruments Inc. | Plunger operated pipet |
US4554134A (en) * | 1982-06-29 | 1985-11-19 | Labsystems Oy | Pipette with adjustable volume |
US4567780A (en) * | 1984-03-12 | 1986-02-04 | American Hospital Supply Corporation | Hand-held pipette with disposable capillary |
US4679446A (en) * | 1985-09-09 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Multi-volume displacement pipette |
US4672857A (en) * | 1985-09-10 | 1987-06-16 | Labindustries, Inc. | Liquid microdispenser |
US4824642A (en) * | 1986-10-21 | 1989-04-25 | Costar Corporation | Multi-channel pipetter |
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US5104624A (en) * | 1989-10-20 | 1992-04-14 | Costar Corporation | Pipetter |
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WO1994003222A2 (en) * | 1992-07-31 | 1994-02-17 | Habley Medical Technology Corporation | Reusable pharmaceutical dispenser with full stroke indicator |
WO1994003222A3 (en) * | 1992-07-31 | 1994-04-28 | Habley Medical Technology Corp | Reusable pharmaceutical dispenser with full stroke indicator |
US5804144A (en) * | 1993-04-21 | 1998-09-08 | Labsystems Oy | Piston pipette |
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US5700959A (en) * | 1995-07-14 | 1997-12-23 | Rainin Instrument Co., Inc. | Manual pipette with magnet assist |
EP0787040A4 (en) * | 1995-07-14 | 1999-05-06 | Rainin Instr Co Inc | HAND PIPETTE WITH MAGNETIC SUPPORT |
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US5792424A (en) * | 1996-03-05 | 1998-08-11 | Rainin Instrument Co., Inc. | Manual pipette with delayed-action home position latch |
US5849248A (en) * | 1996-03-05 | 1998-12-15 | Rainin Instrument Co., Inc. | Adjustable volume pipette with improved volume adjustment lock mechanism |
US6158292A (en) * | 1996-11-04 | 2000-12-12 | Gilson; Warren E. | Pipette |
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US6295880B1 (en) | 1999-12-08 | 2001-10-02 | Warren E. Gilson | Adjustable pipette |
WO2001076747A1 (fr) * | 2000-04-07 | 2001-10-18 | Gilson Incorporated | Pipette de prelevement a demontage simplifie |
FR2807345A1 (fr) * | 2000-04-07 | 2001-10-12 | Gilson Sa | Pipette de prelevement a demontage simplifie |
WO2001076748A1 (fr) * | 2000-04-07 | 2001-10-18 | Gilson Incorporated | Pipette de prelevement munie de moyens de reglage du volume a prelever |
CN100336599C (zh) * | 2000-04-07 | 2007-09-12 | 吉尔松有限合伙公司 | 拆卸简单的移液管 |
FR2807343A1 (fr) * | 2000-04-07 | 2001-10-12 | Gilson Sa | Pipette de prelevement munie de moyens de reglage du volume a prelever |
US6923938B2 (en) | 2001-10-16 | 2005-08-02 | Matrix Technologies Corporation | Hand-held pipettor |
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US8088342B2 (en) | 2001-10-16 | 2012-01-03 | Matrix Technologies Corporation | Hand-held pipettor |
US6926867B1 (en) * | 2001-10-30 | 2005-08-09 | World Precision Instruments, Inc. | Pipette piston seal assembly |
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US20060096349A1 (en) * | 2002-08-27 | 2006-05-11 | Andrzej Czernecki | Method of pipette calibration |
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JP2008500166A (ja) * | 2004-05-27 | 2008-01-10 | マトリックス・テクノロジーズ・コーポレーション | 手持ち式ピペット |
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US11802871B2 (en) * | 2017-07-21 | 2023-10-31 | Helena Laboratories Corporation | System and method for depositing antisera in immunofixation electrophoresis |
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Also Published As
Publication number | Publication date |
---|---|
FR2203680B1 (US20100170793A1-20100708-C00006.png) | 1977-08-12 |
FR2203680A1 (US20100170793A1-20100708-C00006.png) | 1974-05-17 |
GB1439659A (en) | 1976-06-16 |
JPS4975170A (US20100170793A1-20100708-C00006.png) | 1974-07-19 |
JPS5713338B2 (US20100170793A1-20100708-C00006.png) | 1982-03-16 |
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