US3814668A - Method and device for the semi-quantitative determination of glucose in aqueous fluids - Google Patents
Method and device for the semi-quantitative determination of glucose in aqueous fluids Download PDFInfo
- Publication number
- US3814668A US3814668A US00866730A US86673069A US3814668A US 3814668 A US3814668 A US 3814668A US 00866730 A US00866730 A US 00866730A US 86673069 A US86673069 A US 86673069A US 3814668 A US3814668 A US 3814668A
- Authority
- US
- United States
- Prior art keywords
- glucose
- test
- semi
- test device
- iodide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008103 glucose Substances 0.000 title abstract description 42
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract description 40
- 238000000034 method Methods 0.000 title abstract description 11
- 239000012530 fluid Substances 0.000 title abstract description 9
- 238000012360 testing method Methods 0.000 abstract description 77
- 239000000463 material Substances 0.000 abstract description 27
- 239000000203 mixture Substances 0.000 abstract description 27
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 abstract description 17
- 210000002700 urine Anatomy 0.000 abstract description 17
- 108010015776 Glucose oxidase Proteins 0.000 abstract description 12
- 239000004366 Glucose oxidase Substances 0.000 abstract description 11
- 229940116332 glucose oxidase Drugs 0.000 abstract description 11
- 235000019420 glucose oxidase Nutrition 0.000 abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 230000003617 peroxidasic effect Effects 0.000 abstract description 10
- 239000000126 substance Substances 0.000 abstract description 10
- 239000012528 membrane Substances 0.000 abstract description 9
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 abstract description 7
- 239000001856 Ethyl cellulose Substances 0.000 abstract description 7
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract description 7
- 229920001249 ethyl cellulose Polymers 0.000 abstract description 7
- 235000019325 ethyl cellulose Nutrition 0.000 abstract description 7
- 235000012745 brilliant blue FCF Nutrition 0.000 abstract description 6
- 239000004161 brilliant blue FCF Substances 0.000 abstract description 6
- 229940055580 brilliant blue fcf Drugs 0.000 abstract description 6
- 238000004040 coloring Methods 0.000 abstract description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 18
- 239000000243 solution Substances 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 12
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 9
- 230000002209 hydrophobic effect Effects 0.000 description 8
- 230000002255 enzymatic effect Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 6
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 102000003992 Peroxidases Human genes 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 229920003086 cellulose ether Polymers 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 108040007629 peroxidase activity proteins Proteins 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- XZXYQEHISUMZAT-UHFFFAOYSA-N 2-[(2-hydroxy-5-methylphenyl)methyl]-4-methylphenol Chemical compound CC1=CC=C(O)C(CC=2C(=CC=C(C)C=2)O)=C1 XZXYQEHISUMZAT-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 229940107816 ammonium iodide Drugs 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 235000009518 sodium iodide Nutrition 0.000 description 3
- IKHKJYWPWWBSFZ-UHFFFAOYSA-N 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,3-disulfonate;hydron Chemical compound C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S(O)(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 IKHKJYWPWWBSFZ-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 150000004694 iodide salts Chemical class 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000009738 saturating Methods 0.000 description 2
- XOSXWYQMOYSSKB-LDKJGXKFSA-L water blue Chemical compound CC1=CC(/C(\C(C=C2)=CC=C2NC(C=C2)=CC=C2S([O-])(=O)=O)=C(\C=C2)/C=C/C\2=N\C(C=C2)=CC=C2S([O-])(=O)=O)=CC(S(O)(=O)=O)=C1N.[Na+].[Na+] XOSXWYQMOYSSKB-LDKJGXKFSA-L 0.000 description 2
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- NUIURNJTPRWVAP-UHFFFAOYSA-N 3,3'-Dimethylbenzidine Chemical compound C1=C(N)C(C)=CC(C=2C=C(C)C(N)=CC=2)=C1 NUIURNJTPRWVAP-UHFFFAOYSA-N 0.000 description 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 101100168115 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) con-6 gene Proteins 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229960004543 anhydrous citric acid Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000013142 basic testing Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001045 blue dye Substances 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 108010046301 glucose peroxidase Proteins 0.000 description 1
- 230000035780 glucosuria Effects 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 229960003988 indigo carmine Drugs 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000033116 oxidation-reduction process Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
Definitions
- test device as in claim 1 wherein the test device further includes a buffer for maintaining the system in a pH range of from about pH 3.4 to pH 7.2.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00866730A US3814668A (en) | 1969-10-15 | 1969-10-15 | Method and device for the semi-quantitative determination of glucose in aqueous fluids |
| CA094236A CA926282A (en) | 1969-10-15 | 1970-09-28 | Method and device for the semi-quantitative determination of glucose in aqueous fluids |
| ZA706650*A ZA706650B (en) | 1969-10-15 | 1970-09-29 | Method and device for the semi-quantitative determination of glucose in aqeous fluids |
| CH1494370A CH558530A (de) | 1969-10-15 | 1970-10-08 | Testmittel zur halb-quantitativen bestimmung von glukose in waessrigen fluessigkeiten, verfahren zur herstellung des testmittels und deren verwendung. |
| ES384417A ES384417A1 (es) | 1969-10-15 | 1970-10-10 | Un dispositivo de ensayo y un procedimiento para la deter- minacion semicuantitativa de glucosa en fluidos acuosos. |
| GB4866970A GB1320957A (en) | 1969-10-15 | 1970-10-13 | Test device for the determination of glucose in aqueous fluids |
| NL7014994A NL7014994A (enrdf_load_stackoverflow) | 1969-10-15 | 1970-10-13 | |
| DK521970AA DK139795B (da) | 1969-10-15 | 1970-10-14 | Prøvepræparat til semi-kvantitativ bestemmelse af glukose i urin. |
| SE13894/70A SE360178B (enrdf_load_stackoverflow) | 1969-10-15 | 1970-10-14 | |
| NO703869A NO130520C (enrdf_load_stackoverflow) | 1969-10-15 | 1970-10-14 | |
| BE70@@@@@@@@A BE757507A (fr) | 1969-10-15 | 1970-10-14 | Methode et element perfectionnes de dosage semi-quantitatif du glucose dans les liquides aqueux |
| DE19702050481 DE2050481C3 (de) | 1969-10-15 | 1970-10-14 | Diagnostiziermittel zur halbquantitativen Bestimmung von Glukose in Urin |
| FR7037103A FR2065939A5 (enrdf_load_stackoverflow) | 1969-10-15 | 1970-10-14 | |
| JP45089744A JPS5039558B1 (enrdf_load_stackoverflow) | 1969-10-15 | 1970-10-14 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00866730A US3814668A (en) | 1969-10-15 | 1969-10-15 | Method and device for the semi-quantitative determination of glucose in aqueous fluids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3814668A true US3814668A (en) | 1974-06-04 |
Family
ID=25348274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US00866730A Expired - Lifetime US3814668A (en) | 1969-10-15 | 1969-10-15 | Method and device for the semi-quantitative determination of glucose in aqueous fluids |
Country Status (13)
Cited By (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE28575E (en) * | 1971-03-01 | 1975-10-21 | Indicator for detecting hydrogen peroxide and peroxidative compounds containing alpha naphthoflavone | |
| US3920580A (en) * | 1973-07-12 | 1975-11-18 | Miles Lab | Liquid control solution |
| US3964871A (en) * | 1974-12-18 | 1976-06-22 | Becton, Dickinson And Company | Method and device for detecting glucose |
| US3971702A (en) * | 1974-01-09 | 1976-07-27 | Shionogi & Co., Ltd. | Diagnostic composition for saccharide determination |
| US4042329A (en) * | 1974-12-18 | 1977-08-16 | Becton, Dickinson And Company | Method and device for detecting cholesterol |
| US4059407A (en) * | 1976-04-14 | 1977-11-22 | Becton, Dickinson And Company | Disposable chemical indicators |
| US4066408A (en) * | 1974-10-16 | 1978-01-03 | Ab Kabi | Chromogen-reactive-indicator preparations containing a 3,3'-di(carbonyloxy- or sulfonyloxy-group-containing) benzidine derivative chromogen |
| US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
| EP0036543A1 (en) * | 1980-03-20 | 1981-09-30 | Miles Laboratories, Inc. | Improved method and device for the semiquantitative determination of glucose in aqueous fluids and method of preparing the device |
| US4340669A (en) * | 1981-02-12 | 1982-07-20 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| US4391905A (en) * | 1981-02-12 | 1983-07-05 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| US4391906A (en) * | 1981-02-12 | 1983-07-05 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| WO1985001747A1 (en) * | 1983-10-17 | 1985-04-25 | Inomedix, Incorporated | Device for rapid quantitative analysis of a fluid |
| US4621049A (en) * | 1984-11-19 | 1986-11-04 | Miles Laboratories, Inc. | Enzymatic high range glucose test |
| US4690815A (en) * | 1985-08-15 | 1987-09-01 | Charles Of The Ritz Group Ltd. | Method for testing skin for presence of moisturizer |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| US4981805A (en) * | 1980-01-18 | 1991-01-01 | Fuji Photo Film Co., Ltd. | Method of using chemical analysis slide |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| WO1992022806A1 (en) * | 1991-06-17 | 1992-12-23 | Serim Research Corporation | Test for per acids |
| US5192693A (en) * | 1980-01-18 | 1993-03-09 | Fuji Photo Film Co., Ltd. | Method of using chemical analysis slide |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| US5434057A (en) * | 1994-02-02 | 1995-07-18 | Quidel Corporation | Sperm motility assay and devices |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5906916A (en) * | 1997-11-12 | 1999-05-25 | Integrated Biomedical Technology Inc. | Peroxide test strip |
| US6087089A (en) * | 1997-11-12 | 2000-07-11 | Integrated Biomedical Technology, Inc. | Peroxide and chlorine test strip |
| US6444169B1 (en) | 2001-06-18 | 2002-09-03 | Ralston Purina Company | Test-device for threshold glucose detection in urine |
| US20030068666A1 (en) * | 2001-10-05 | 2003-04-10 | Zweig Stephen Eliot | Dual glucose-hydroxybutyrate analytical sensors |
| US20060051738A1 (en) * | 2001-10-05 | 2006-03-09 | Zweig Stephen E | Dual glucose-turbidimetric analytical sensors |
| US20090035865A1 (en) * | 2007-08-01 | 2009-02-05 | Demoor Colette Pamela | Moisture sensor |
| US20090047176A1 (en) * | 2007-08-16 | 2009-02-19 | Cregger Tricia A | Indicator for monitoring a sterilization process |
| US20100255592A1 (en) * | 2007-05-02 | 2010-10-07 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
| WO2014126995A1 (en) | 2013-02-14 | 2014-08-21 | Siemens Healthcare Diagnostics Inc. | Reduction of false positive on reagent test devices |
| US9572922B2 (en) | 2012-12-21 | 2017-02-21 | Larry Leonard | Inventive diabetic systems, tools, kits, and supplies for better diabetic living and mobility |
| US9606103B2 (en) | 2011-12-16 | 2017-03-28 | Siemens Healthcare Diagnostics Inc. | Waste ramp for reagent cards |
| EP3301433A1 (en) | 2012-03-09 | 2018-04-04 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| CN108120713A (zh) * | 2017-12-20 | 2018-06-05 | 青岛汉唐生物科技有限公司 | 一种尿糖试纸及其制备方法 |
| WO2022226504A1 (en) | 2021-04-23 | 2022-10-27 | Siemens Healthcare Diagnostics Inc. | Analyzer having automatic test type sensing |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT347600B (de) | 1974-11-11 | 1979-01-10 | Wellcome Found | Testeinrichtungen |
| US4717658A (en) * | 1985-12-03 | 1988-01-05 | Miles Inc. | Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL) |
| CN106323723B (zh) * | 2016-11-30 | 2019-01-22 | 宁夏大学 | 双蓝染色法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3183173A (en) * | 1963-06-10 | 1965-05-11 | Miles Lab | Test composition for detecting hydrogen peroxide |
| US3438737A (en) * | 1965-10-01 | 1969-04-15 | Miles Lab | Protein test composition,device and method |
-
1969
- 1969-10-15 US US00866730A patent/US3814668A/en not_active Expired - Lifetime
-
1970
- 1970-09-28 CA CA094236A patent/CA926282A/en not_active Expired
- 1970-09-29 ZA ZA706650*A patent/ZA706650B/xx unknown
- 1970-10-08 CH CH1494370A patent/CH558530A/xx not_active IP Right Cessation
- 1970-10-10 ES ES384417A patent/ES384417A1/es not_active Expired
- 1970-10-13 NL NL7014994A patent/NL7014994A/xx unknown
- 1970-10-13 GB GB4866970A patent/GB1320957A/en not_active Expired
- 1970-10-14 NO NO703869A patent/NO130520C/no unknown
- 1970-10-14 DK DK521970AA patent/DK139795B/da not_active IP Right Cessation
- 1970-10-14 FR FR7037103A patent/FR2065939A5/fr not_active Expired
- 1970-10-14 BE BE70@@@@@@@@A patent/BE757507A/xx unknown
- 1970-10-14 SE SE13894/70A patent/SE360178B/xx unknown
- 1970-10-14 JP JP45089744A patent/JPS5039558B1/ja active Pending
Cited By (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE28575E (en) * | 1971-03-01 | 1975-10-21 | Indicator for detecting hydrogen peroxide and peroxidative compounds containing alpha naphthoflavone | |
| US3920580A (en) * | 1973-07-12 | 1975-11-18 | Miles Lab | Liquid control solution |
| US3971702A (en) * | 1974-01-09 | 1976-07-27 | Shionogi & Co., Ltd. | Diagnostic composition for saccharide determination |
| US4066408A (en) * | 1974-10-16 | 1978-01-03 | Ab Kabi | Chromogen-reactive-indicator preparations containing a 3,3'-di(carbonyloxy- or sulfonyloxy-group-containing) benzidine derivative chromogen |
| US3964871A (en) * | 1974-12-18 | 1976-06-22 | Becton, Dickinson And Company | Method and device for detecting glucose |
| US4042329A (en) * | 1974-12-18 | 1977-08-16 | Becton, Dickinson And Company | Method and device for detecting cholesterol |
| US4059407A (en) * | 1976-04-14 | 1977-11-22 | Becton, Dickinson And Company | Disposable chemical indicators |
| US4160008A (en) * | 1978-01-26 | 1979-07-03 | Miles Laboratories, Inc. | Multilayered test device for determining the presence of a liquid sample component, and method of use |
| US5192693A (en) * | 1980-01-18 | 1993-03-09 | Fuji Photo Film Co., Ltd. | Method of using chemical analysis slide |
| US4981805A (en) * | 1980-01-18 | 1991-01-01 | Fuji Photo Film Co., Ltd. | Method of using chemical analysis slide |
| EP0036543A1 (en) * | 1980-03-20 | 1981-09-30 | Miles Laboratories, Inc. | Improved method and device for the semiquantitative determination of glucose in aqueous fluids and method of preparing the device |
| US4303753A (en) * | 1980-03-20 | 1981-12-01 | Miles Laboratories, Inc. | Method and device for the semiquantitative determination of glucose in aqueous fluids |
| US4391905A (en) * | 1981-02-12 | 1983-07-05 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| US4391906A (en) * | 1981-02-12 | 1983-07-05 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| US4340669A (en) * | 1981-02-12 | 1982-07-20 | Miles Laboratories, Inc. | System for the determination of glucose in fluids |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| WO1985001747A1 (en) * | 1983-10-17 | 1985-04-25 | Inomedix, Incorporated | Device for rapid quantitative analysis of a fluid |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| US4621049A (en) * | 1984-11-19 | 1986-11-04 | Miles Laboratories, Inc. | Enzymatic high range glucose test |
| US4690815A (en) * | 1985-08-15 | 1987-09-01 | Charles Of The Ritz Group Ltd. | Method for testing skin for presence of moisturizer |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| WO1992022806A1 (en) * | 1991-06-17 | 1992-12-23 | Serim Research Corporation | Test for per acids |
| US5434057A (en) * | 1994-02-02 | 1995-07-18 | Quidel Corporation | Sperm motility assay and devices |
| US6087089A (en) * | 1997-11-12 | 2000-07-11 | Integrated Biomedical Technology, Inc. | Peroxide and chlorine test strip |
| US5906916A (en) * | 1997-11-12 | 1999-05-25 | Integrated Biomedical Technology Inc. | Peroxide test strip |
| US6444169B1 (en) | 2001-06-18 | 2002-09-03 | Ralston Purina Company | Test-device for threshold glucose detection in urine |
| US6599474B2 (en) | 2001-06-18 | 2003-07-29 | Nestec, Ltd. | Threshold glucose detection in urine |
| US6682937B2 (en) | 2001-06-18 | 2004-01-27 | Hach Company | Threshold glucose detection in urine |
| US20030068666A1 (en) * | 2001-10-05 | 2003-04-10 | Zweig Stephen Eliot | Dual glucose-hydroxybutyrate analytical sensors |
| US6984307B2 (en) | 2001-10-05 | 2006-01-10 | Stephen Eliot Zweig | Dual glucose-hydroxybutyrate analytical sensors |
| US20060051738A1 (en) * | 2001-10-05 | 2006-03-09 | Zweig Stephen E | Dual glucose-turbidimetric analytical sensors |
| US7758744B2 (en) | 2001-10-05 | 2010-07-20 | Stephen Eliot Zweig | Dual glucose-turbidimetric analytical sensors |
| US8304254B2 (en) | 2007-05-02 | 2012-11-06 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
| US20100255592A1 (en) * | 2007-05-02 | 2010-10-07 | Siemens Healthcare Diagnostics Inc. | Piezo dispensing of a diagnostic liquid onto a reagent surface |
| US20090035865A1 (en) * | 2007-08-01 | 2009-02-05 | Demoor Colette Pamela | Moisture sensor |
| US20090047176A1 (en) * | 2007-08-16 | 2009-02-19 | Cregger Tricia A | Indicator for monitoring a sterilization process |
| US8512633B2 (en) | 2007-08-16 | 2013-08-20 | American Sterilizer Company | Indicator for monitoring a sterilization process |
| US9606103B2 (en) | 2011-12-16 | 2017-03-28 | Siemens Healthcare Diagnostics Inc. | Waste ramp for reagent cards |
| US10444221B2 (en) | 2011-12-16 | 2019-10-15 | Siemens Healthcare Diagnostics Inc. | Method of transferring a reagent card from a card travel surface of an automated analyzer to a waste receptacle |
| US11187694B2 (en) | 2011-12-16 | 2021-11-30 | Siemens Healthcare Diagnostics Inc. | Method for assembling an automated analyzer, waste ramp, and waste receptacle for reagent cards |
| EP3301433A1 (en) | 2012-03-09 | 2018-04-04 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| US11035799B2 (en) | 2012-03-09 | 2021-06-15 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| US12146835B2 (en) | 2012-03-09 | 2024-11-19 | Siemens Healthcare Diagnostics Inc. | Calibration method for reagent card analyzers |
| US9572922B2 (en) | 2012-12-21 | 2017-02-21 | Larry Leonard | Inventive diabetic systems, tools, kits, and supplies for better diabetic living and mobility |
| WO2014126995A1 (en) | 2013-02-14 | 2014-08-21 | Siemens Healthcare Diagnostics Inc. | Reduction of false positive on reagent test devices |
| US9612249B2 (en) | 2013-02-14 | 2017-04-04 | Siemens Healthcare Diagnostics Inc. | Reduction of false positive on reagent test devices |
| CN108120713A (zh) * | 2017-12-20 | 2018-06-05 | 青岛汉唐生物科技有限公司 | 一种尿糖试纸及其制备方法 |
| WO2022226504A1 (en) | 2021-04-23 | 2022-10-27 | Siemens Healthcare Diagnostics Inc. | Analyzer having automatic test type sensing |
Also Published As
| Publication number | Publication date |
|---|---|
| NO130520B (enrdf_load_stackoverflow) | 1974-09-16 |
| DE2050481B2 (de) | 1976-12-23 |
| DK139795C (enrdf_load_stackoverflow) | 1979-10-15 |
| SE360178B (enrdf_load_stackoverflow) | 1973-09-17 |
| CA926282A (en) | 1973-05-15 |
| NO130520C (enrdf_load_stackoverflow) | 1974-12-27 |
| ZA706650B (en) | 1971-05-27 |
| NL7014994A (enrdf_load_stackoverflow) | 1971-04-19 |
| FR2065939A5 (enrdf_load_stackoverflow) | 1971-08-06 |
| CH558530A (de) | 1975-01-31 |
| DE2050481A1 (de) | 1971-04-29 |
| DK139795B (da) | 1979-04-17 |
| JPS5039558B1 (enrdf_load_stackoverflow) | 1975-12-17 |
| BE757507A (fr) | 1971-03-16 |
| ES384417A1 (es) | 1973-09-16 |
| GB1320957A (en) | 1973-06-20 |
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