US3807400A - Inhaling device for medicinal powder compositions - Google Patents
Inhaling device for medicinal powder compositions Download PDFInfo
- Publication number
- US3807400A US3807400A US00266243A US26624372A US3807400A US 3807400 A US3807400 A US 3807400A US 00266243 A US00266243 A US 00266243A US 26624372 A US26624372 A US 26624372A US 3807400 A US3807400 A US 3807400A
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- United States
- Prior art keywords
- capsule
- piercing
- medicinal powder
- inhaling device
- platform
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.
- FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;
- FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;
- FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;
- FIG. 4 is a radial partial sectional view of the inhaling device of the invention.
- FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition.
- the lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.
- the central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.
- the component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.
- Component 1 which extend in the assembled position into the said tangential passages or gaps 61.
- Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.
- the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14.
- the member 12 is formed with outlet openings 52 for the powder to be inhaled.
- a net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.
- the component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7.
- the piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7.
- a piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9.
- the needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.
- a plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.
- two diametrally opposed piercing devices P are provided.
- the capsule After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt.
- the cams and recesses 69 Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected.
- the patient with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.
- An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
- the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition. The invention essentially resides in the provision of a mouth piece that is of a telescopic structure and in the provision of two piercing devices that are provided into a rotatable member according to a diametral opposed position and are actuated by the member, the telescoping structure when extended forming the whirling chamber, the mantel of the latter mentioned member being formed with a cam able to give a number of piercing operations to both piercing devices.
Description
United States Patent [1 1 Cocozza Apr. 30, 1974 INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS [75] Inventor: Salvatore Cocozza, Milano, Italy [73] Assignee: I. S. F. S.p.A., Milano, Italy [22] Filed: June 26, 1972 [21] Appl. No.: 266,243
[30] Foreign Application Priority Data July 17, 1971 Italy 26971/71 [52] US. Cl 128/266, 128/206, 128/208 [51] Int. Cl A6lm 13/00 [58] Field of Search 128/266, 206, 208, 272;
[56] References Cited UNITED STATES PATENTS 2,573,918 11/1958 McCuiston 128/206 3,507,277 4/1970 Altounyan et a1. 128/208 3,518,992 7/1970 Altounyan et a1. 128/208 3,635,219 1/1972 Altounyan et al. 128/266 3,669,113 6/1972 Altounyan et a1. 128/266 FOREIGN PATENTS OR APPLICATIONS 208,211 12/1967 U.S.S.R 128/266 Primary ExaminerAldrich F. Medbery Attorney, Agent, or Firm--Eric H. Waters [57] ABSTRACT This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition,
'number of piercing operations to both piercing devices.
2 Claims, 7 Drawing Figures INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS FIELD OF THE INVENTION The present invention relates to improvements in or modifications of inhaling devices for'medicinal powder compositions in capsule form.
SUMMARY OF THE INVENTION It is an object of the present invention to provide an inhaling device of economical construction, of high efficiency which is able to be used by any category of patients and for any kind of powder compositions contained in capsules.
It is a further object of the present invention to provide a compact inhaling device of substantially reduced overall dimension as compared with known devices for use with medicinal powder composition capsule form.
According to the present invention, there is provided an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.
BRIEF DESCRIPTION OF THE DRAWINGS The invention will be further illustrated, by way of example, with reference to the accompanying drawings, in which: I
FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;
FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;
FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;
FIG. 4 is a radial partial sectional view of the inhaling device of the invention;
FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition. The lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.
"ll'teupper member comprising two components 1 and 2, together with the lower member 31 forms a mixing chamber W for the contents of the pierced capsule, which are subjected to a whirling action therein.
The central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.
The component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.
which extend in the assembled position into the said tangential passages or gaps 61. Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.
In operation, the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14. The member 12 is formed with outlet openings 52 for the powder to be inhaled. A net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.
The component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7. The piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7. A piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9. The needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.
A plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.
In order to obtain two diametrally opposed perforations in the capsule 45, two diametrally opposed piercing devices P are provided.
Operation of the inhaling device of the invention is as follows:
After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt. Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected. The patient, with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.
The preceding description makes it evident that the mentioned objects of the invention have been fully attained. In the light of the disclosure changes and modifications within the true spirit and scope of the invention will occur to others, and accordingly it is not desired that the scope of the invention be restricted except as is required by the appended claims.
What I claim is:
1. An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
2. An inhaling device as claimed in claim 1, in which the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.
Claims (2)
1. An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
2. An inhaling device as claimed in claim 1, in which the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT26971/71A IT941426B (en) | 1971-07-17 | 1971-07-17 | SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES |
Publications (1)
Publication Number | Publication Date |
---|---|
US3807400A true US3807400A (en) | 1974-04-30 |
Family
ID=11220655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00266243A Expired - Lifetime US3807400A (en) | 1971-07-17 | 1972-06-26 | Inhaling device for medicinal powder compositions |
Country Status (10)
Country | Link |
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US (1) | US3807400A (en) |
AT (1) | AT333415B (en) |
BE (1) | BE781102A (en) |
CA (1) | CA999202A (en) |
CH (1) | CH563167A5 (en) |
ES (1) | ES208808Y (en) |
FR (1) | FR2146202B1 (en) |
GB (1) | GB1331216A (en) |
IT (1) | IT941426B (en) |
NL (1) | NL7305363A (en) |
Cited By (98)
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---|---|---|---|---|
US3858583A (en) * | 1973-02-26 | 1975-01-07 | Allen & Hanburys Ltd | Medicament inhalation device |
US3870046A (en) * | 1973-05-08 | 1975-03-11 | Miles Lab | Insufflator |
US3938516A (en) * | 1975-01-13 | 1976-02-17 | Syntex Puerto Rico, Inc. | Inhalation device |
US3948264A (en) * | 1975-05-21 | 1976-04-06 | Mead Johnson & Company | Inhalation device |
US3964483A (en) * | 1975-01-13 | 1976-06-22 | Syntex Puerto Rico, Inc. | Inhalation device |
US3973566A (en) * | 1975-01-13 | 1976-08-10 | Syntex Puerto Rico Inc. | Inhalation device |
US3991761A (en) * | 1974-03-18 | 1976-11-16 | Salvatore Cocozza | Inhaler for powdered medicaments |
US4014336A (en) * | 1975-01-13 | 1977-03-29 | Syntex Puerto Rico, Inc. | Inhalation device |
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
US4095596A (en) * | 1976-11-26 | 1978-06-20 | Smithkline Corporation | Nasal inhaler |
US4155359A (en) * | 1977-05-23 | 1979-05-22 | Antoni Zagorski | Air filtering mask |
US4249526A (en) * | 1978-05-03 | 1981-02-10 | Fisons Limited | Inhalation device |
EP0041783A1 (en) * | 1980-06-06 | 1981-12-16 | FISONS plc | Inhalation device for powdered medicaments |
DK154399B (en) * | 1976-02-10 | 1988-11-14 | Allen & Hanburys Ltd | inhaler |
US4884565A (en) * | 1987-08-17 | 1989-12-05 | Miat S.P.A. | Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5207217A (en) * | 1990-07-16 | 1993-05-04 | Promo Pack Sa | Multiple single-dose inhaler for medicaments in powder form |
US5331953A (en) * | 1989-03-07 | 1994-07-26 | Aktiebolaget Draco | Device in connection with an inhaler |
US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
US5460173A (en) * | 1993-03-03 | 1995-10-24 | Tenax Corporation | Dry powder inhaler medicament carrier |
US5522383A (en) * | 1990-06-14 | 1996-06-04 | Rhone-Poulenc Rorer Ltd. | Powder inhaler having capsule holding structure and anti-static walls |
US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US5676130A (en) * | 1992-03-19 | 1997-10-14 | Boehringer Ingelheim Gmbh, Inc. | Separator for powdered inhalers |
US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5988163A (en) * | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
WO1999064095A2 (en) | 1998-06-12 | 1999-12-16 | Microdose Technologies, Inc. | Metering, packaging and delivery of pharmaceuticals and drugs |
US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
US6142146A (en) * | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
US6152130A (en) * | 1998-06-12 | 2000-11-28 | Microdose Technologies, Inc. | Inhalation device with acoustic control |
US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US6237591B1 (en) | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
WO2001062342A1 (en) * | 2000-02-24 | 2001-08-30 | Irm Technologies Pty Ltd | Nasal filter and sampler |
EP1204437A1 (en) * | 1999-07-20 | 2002-05-15 | Thayer Medical Corporation | Collapsible, disposable mdi spacer and method |
US20020134382A1 (en) * | 2000-05-10 | 2002-09-26 | Snow John M. | Medicament container with same side airflow inlet and outlet and method of use |
US20030047184A1 (en) * | 2001-01-12 | 2003-03-13 | Lockhart Artis R. | Medicament respiratory delivery device |
US6672304B1 (en) | 1995-06-08 | 2004-01-06 | Innovative Devices, Llc | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US20040149283A1 (en) * | 2002-12-12 | 2004-08-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient |
US20040163645A1 (en) * | 2001-01-12 | 2004-08-26 | Connelly Robert I. | Medicament inhalation delivery devices and methods for using the same |
US6792945B2 (en) * | 1990-03-02 | 2004-09-21 | Glaxo Group Limited | Inhalation device |
US20040237961A1 (en) * | 1995-06-08 | 2004-12-02 | Snow John Medlin | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US20050126568A1 (en) * | 1990-03-02 | 2005-06-16 | Davies Michael B. | Inhalation device |
US20050158394A1 (en) * | 2000-02-28 | 2005-07-21 | Vectura Limited | Delivery of oral drugs |
US20050172962A1 (en) * | 2004-02-06 | 2005-08-11 | Microdose Technologies, Inc. | Blister pack for use with an inhalation device |
US20050183725A1 (en) * | 2004-02-24 | 2005-08-25 | Microdose Technologies, Inc. | Directional flow sensor inhaler |
US20050183724A1 (en) * | 2004-02-24 | 2005-08-25 | Microdose Technologies, Inc. | Synthetic jet based medicament delivery method and apparatus |
WO2006051300A1 (en) * | 2004-11-10 | 2006-05-18 | Cipla Limited | Inhaler |
US20060157054A1 (en) * | 2005-01-11 | 2006-07-20 | Boehringer Lngelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
US7080644B2 (en) | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US20070107722A1 (en) * | 2005-11-15 | 2007-05-17 | Hubert Hoelz | Needle for piercing a powder capsule for inhalation |
US20070209661A1 (en) * | 2006-03-03 | 2007-09-13 | Hugh Smyth | Dry powder inhaler with aeroelastic dispersion mechanism |
WO2007107160A1 (en) | 2006-03-21 | 2007-09-27 | Bang & Olufsen Medicom A/S | Inhaler flow channel |
US20070240712A1 (en) * | 2006-04-05 | 2007-10-18 | Scott Fleming | Variable dose inhalation device |
US20070240713A1 (en) * | 2006-04-11 | 2007-10-18 | Georg Boeck | Inhaler |
US20080160076A1 (en) * | 1998-08-05 | 2008-07-03 | Dieter Hochrainer | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
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US20090320838A1 (en) * | 2006-06-16 | 2009-12-31 | Cipla Limited | Dry powder inhaler |
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US20110056488A1 (en) * | 2008-01-24 | 2011-03-10 | Vectura Delivery Devices Limited | Inhaler |
US20110162642A1 (en) * | 2010-01-05 | 2011-07-07 | Akouka Henri M | Inhalation device and method |
EP2357015A2 (en) | 2006-04-05 | 2011-08-17 | MicroDose Therapeutx, Inc. | Variable dose inhalation device |
EP2594272A2 (en) | 2005-05-18 | 2013-05-22 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8561609B2 (en) | 2010-12-07 | 2013-10-22 | Respira Therapeutics, Inc. | Dry powder inhaler |
US8748488B2 (en) | 2008-05-30 | 2014-06-10 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
US8985101B2 (en) | 2009-05-21 | 2015-03-24 | Microdose Therapeutx, Inc. | Method and device for clamping a blister within a dry powder inhaler |
WO2015075433A1 (en) | 2013-11-19 | 2015-05-28 | Cipla Limited | Inhaler device |
US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
WO2015128789A1 (en) | 2014-02-25 | 2015-09-03 | Lupin Limited | Inhaler |
WO2015143012A1 (en) | 2014-03-19 | 2015-09-24 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015179369A1 (en) | 2014-05-20 | 2015-11-26 | Infinity Pharmaceuticals, Inc. | Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors |
WO2016007356A1 (en) | 2014-07-07 | 2016-01-14 | Microdose Therapeutx, Inc. | Inhalation device |
WO2016014586A1 (en) | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder medicament de-agglomerator |
WO2016014154A1 (en) | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder nebulizer |
US9492625B2 (en) | 2009-11-12 | 2016-11-15 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
US20170095625A1 (en) * | 2014-06-04 | 2017-04-06 | Merck Sharp & Dohme Corp. | Dry powder inhaler with dose depletion evaluation |
US9700564B2 (en) | 2009-09-04 | 2017-07-11 | Horizon Orphan Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
US10028966B2 (en) | 2014-01-10 | 2018-07-24 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10238821B2 (en) | 2016-10-11 | 2019-03-26 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
US10441733B2 (en) | 2012-06-25 | 2019-10-15 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
US20200139057A1 (en) * | 2017-06-27 | 2020-05-07 | Korea United Pharm. Inc. | Dry powder inhaler |
EP3782604A1 (en) | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
US11224704B2 (en) * | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
EP4059499A1 (en) | 2011-01-31 | 2022-09-21 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US11471623B2 (en) | 2012-02-21 | 2022-10-18 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1404338A (en) * | 1972-08-04 | 1975-08-28 | Beecham Group Ltd | Device for the inhalation of medicaments |
DE2346914C3 (en) * | 1973-09-18 | 1980-10-16 | Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg | Powdered substance inhaler |
DE3050005A1 (en) * | 1979-10-30 | 1982-03-18 | Riker Laboratories Inc | BREATH ACTUATED DEVICES FOR ADMINISTERING POWDERED MEDICAMENTS |
ES506585A0 (en) * | 1980-10-30 | 1982-09-01 | Riker Laboratories Inc | A DEVICE TO FACILITATE THE ORAL INHALATION OF MEDICINES IN THE FORM OF POWDER |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
GB2253200A (en) * | 1991-02-01 | 1992-09-02 | Harris Pharma Ltd | Inhalation apparatus and fracturable capsule for use therewith |
US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
DE4239402A1 (en) * | 1992-11-24 | 1994-05-26 | Bayer Ag | Multiple dosage powder inhaler - has acceleration channel and dwell chamber for uniformly high drug dispersion |
CA2212430A1 (en) | 1997-08-07 | 1999-02-07 | George Volgyesi | Inhalation device |
DE10258360A1 (en) | 2002-12-12 | 2004-06-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Chamber for accommodation of disposable capsules for powder inhalers has an inner surface with protruding elements serving as distance pieces between the capsules |
DE102006016904A1 (en) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | inhaler |
DE102006016901A1 (en) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Mouthpiece for an inhaler |
AU2008206361A1 (en) | 2007-01-12 | 2008-07-24 | Opex Corporation | Method and apparatus for sorting items |
DE102007033860A1 (en) | 2007-07-20 | 2009-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Test arrangement for testing sealing between mouthpiece of inhaler and user's lips has channel for secondary air around user's lips with second flow measurement device |
DE102007052871A1 (en) | 2007-11-02 | 2009-05-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Capsule for receiving pharmaceutical drug formulations |
DE202008015493U1 (en) | 2008-11-21 | 2009-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | folding |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU208211A1 (en) * | А. С. Пономарев | |||
US2573918A (en) * | 1949-11-05 | 1951-11-06 | Vick Chemical Company | Device for dispensing medicaments |
US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
US3518992A (en) * | 1966-09-17 | 1970-07-07 | Fisons Pharmaceuticals Ltd | Oral inhaler with spring biased,cam driven piercing device |
US3635219A (en) * | 1968-06-07 | 1972-01-18 | Fisons Pharmaceuticals Ltd | Inhalation device |
US3669113A (en) * | 1966-03-07 | 1972-06-13 | Fisons Ltd | Inhalation device |
-
1971
- 1971-07-17 IT IT26971/71A patent/IT941426B/en active
-
1972
- 1972-03-21 FR FR7210735A patent/FR2146202B1/fr not_active Expired
- 1972-03-23 BE BE781102A patent/BE781102A/en unknown
- 1972-03-24 ES ES1972208808U patent/ES208808Y/en not_active Expired
- 1972-05-26 GB GB2489272A patent/GB1331216A/en not_active Expired
- 1972-05-29 CA CA143,380A patent/CA999202A/en not_active Expired
- 1972-06-26 US US00266243A patent/US3807400A/en not_active Expired - Lifetime
-
1973
- 1973-04-17 NL NL7305363A patent/NL7305363A/xx unknown
- 1973-04-18 AT AT346473A patent/AT333415B/en not_active IP Right Cessation
- 1973-04-30 CH CH619173A patent/CH563167A5/xx not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU208211A1 (en) * | А. С. Пономарев | |||
US2573918A (en) * | 1949-11-05 | 1951-11-06 | Vick Chemical Company | Device for dispensing medicaments |
US3669113A (en) * | 1966-03-07 | 1972-06-13 | Fisons Ltd | Inhalation device |
US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
US3518992A (en) * | 1966-09-17 | 1970-07-07 | Fisons Pharmaceuticals Ltd | Oral inhaler with spring biased,cam driven piercing device |
US3635219A (en) * | 1968-06-07 | 1972-01-18 | Fisons Pharmaceuticals Ltd | Inhalation device |
Cited By (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3858583A (en) * | 1973-02-26 | 1975-01-07 | Allen & Hanburys Ltd | Medicament inhalation device |
US4069819A (en) * | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
US3870046A (en) * | 1973-05-08 | 1975-03-11 | Miles Lab | Insufflator |
US3991761A (en) * | 1974-03-18 | 1976-11-16 | Salvatore Cocozza | Inhaler for powdered medicaments |
US3938516A (en) * | 1975-01-13 | 1976-02-17 | Syntex Puerto Rico, Inc. | Inhalation device |
US3964483A (en) * | 1975-01-13 | 1976-06-22 | Syntex Puerto Rico, Inc. | Inhalation device |
US3973566A (en) * | 1975-01-13 | 1976-08-10 | Syntex Puerto Rico Inc. | Inhalation device |
US4014336A (en) * | 1975-01-13 | 1977-03-29 | Syntex Puerto Rico, Inc. | Inhalation device |
US3948264A (en) * | 1975-05-21 | 1976-04-06 | Mead Johnson & Company | Inhalation device |
DK154399B (en) * | 1976-02-10 | 1988-11-14 | Allen & Hanburys Ltd | inhaler |
US4095596A (en) * | 1976-11-26 | 1978-06-20 | Smithkline Corporation | Nasal inhaler |
US4155359A (en) * | 1977-05-23 | 1979-05-22 | Antoni Zagorski | Air filtering mask |
US4249526A (en) * | 1978-05-03 | 1981-02-10 | Fisons Limited | Inhalation device |
EP0041783A1 (en) * | 1980-06-06 | 1981-12-16 | FISONS plc | Inhalation device for powdered medicaments |
US4884565A (en) * | 1987-08-17 | 1989-12-05 | Miat S.P.A. | Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola |
US5331953A (en) * | 1989-03-07 | 1994-07-26 | Aktiebolaget Draco | Device in connection with an inhaler |
US6048857A (en) * | 1989-10-17 | 2000-04-11 | Ellinwood, Jr.; Everett H. | Dosing method of administering medicaments via inhalation administration |
US7225808B2 (en) | 1990-03-02 | 2007-06-05 | Glaxo Group Limited | Inhalation device |
US6792945B2 (en) * | 1990-03-02 | 2004-09-21 | Glaxo Group Limited | Inhalation device |
US20070107724A9 (en) * | 1990-03-02 | 2007-05-17 | Davies Michael B | Inhalation device |
US20050126568A1 (en) * | 1990-03-02 | 2005-06-16 | Davies Michael B. | Inhalation device |
US7389775B2 (en) | 1990-03-02 | 2008-06-24 | Glaxo Group Limited | Inhalation device |
US5522383A (en) * | 1990-06-14 | 1996-06-04 | Rhone-Poulenc Rorer Ltd. | Powder inhaler having capsule holding structure and anti-static walls |
US5207217A (en) * | 1990-07-16 | 1993-05-04 | Promo Pack Sa | Multiple single-dose inhaler for medicaments in powder form |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5676130A (en) * | 1992-03-19 | 1997-10-14 | Boehringer Ingelheim Gmbh, Inc. | Separator for powdered inhalers |
US5460173A (en) * | 1993-03-03 | 1995-10-24 | Tenax Corporation | Dry powder inhaler medicament carrier |
US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
US20040237961A1 (en) * | 1995-06-08 | 2004-12-02 | Snow John Medlin | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US6672304B1 (en) | 1995-06-08 | 2004-01-06 | Innovative Devices, Llc | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US6729324B2 (en) | 1995-06-08 | 2004-05-04 | Innovative Devices, Llc. | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US5988163A (en) * | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5823183A (en) * | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5692496A (en) * | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US6561186B2 (en) | 1995-08-02 | 2003-05-13 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US6550477B1 (en) | 1995-08-02 | 2003-04-22 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
US6142146A (en) * | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
US6152130A (en) * | 1998-06-12 | 2000-11-28 | Microdose Technologies, Inc. | Inhalation device with acoustic control |
WO1999064095A2 (en) | 1998-06-12 | 1999-12-16 | Microdose Technologies, Inc. | Metering, packaging and delivery of pharmaceuticals and drugs |
US20080160076A1 (en) * | 1998-08-05 | 2008-07-03 | Dieter Hochrainer | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
US8298575B2 (en) | 1998-08-05 | 2012-10-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule to accept pharmaceutical preparations for powder inhalers |
US6237591B1 (en) | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
EP1204437A4 (en) * | 1999-07-20 | 2003-01-22 | Thayer Medical Corp | Collapsible, disposable mdi spacer and method |
EP1204437A1 (en) * | 1999-07-20 | 2002-05-15 | Thayer Medical Corporation | Collapsible, disposable mdi spacer and method |
US20030106555A1 (en) * | 2000-02-24 | 2003-06-12 | Euan Tovey | Nasal filter and sampler |
WO2001062342A1 (en) * | 2000-02-24 | 2001-08-30 | Irm Technologies Pty Ltd | Nasal filter and sampler |
EP1941868A2 (en) | 2000-02-28 | 2008-07-09 | PharmaKodex Limited | Improvements in or relating to the delivery of oral drugs |
US20050158394A1 (en) * | 2000-02-28 | 2005-07-21 | Vectura Limited | Delivery of oral drugs |
US7318436B2 (en) | 2000-05-10 | 2008-01-15 | Innovative Devices, Llc | Medicament container with same side airflow inlet and outlet and method of use |
US6948494B1 (en) | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
US20020134382A1 (en) * | 2000-05-10 | 2002-09-26 | Snow John M. | Medicament container with same side airflow inlet and outlet and method of use |
US20050056281A1 (en) * | 2000-05-10 | 2005-03-17 | Snow John M. | Medicament container with same side airflow inlet and outlet and method of use |
US7810495B2 (en) | 2000-06-28 | 2010-10-12 | Microdose Therapeutx, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US7950390B2 (en) | 2000-06-28 | 2011-05-31 | Microdose Therapeutx, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US20110030679A1 (en) * | 2000-06-28 | 2011-02-10 | Gumaste Anand V | Packaging and delivery of pharmaceuticals and drugs |
US20090314288A1 (en) * | 2000-06-28 | 2009-12-24 | Gumaste Anand V | Packaging and delivery of pharmaceuticals and drugs |
US7080644B2 (en) | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US8573202B2 (en) | 2000-06-28 | 2013-11-05 | Microdose Therapeutx, Inc. | Packaging and delivery of pharmaceuticals and drugs |
US20060237011A1 (en) * | 2000-06-28 | 2006-10-26 | Gumaste Anand V | Packaging and delivery of pharmaceuticals and drugs |
US20040163645A1 (en) * | 2001-01-12 | 2004-08-26 | Connelly Robert I. | Medicament inhalation delivery devices and methods for using the same |
US20080006269A1 (en) * | 2001-01-12 | 2008-01-10 | Lockhart Artis R | Medicament Respiratory Delivery Device |
US20030047184A1 (en) * | 2001-01-12 | 2003-03-13 | Lockhart Artis R. | Medicament respiratory delivery device |
US7270127B2 (en) | 2001-01-12 | 2007-09-18 | Becton, Dickinson And Company | Medicament respiratory delivery device |
US7040316B2 (en) * | 2001-01-12 | 2006-05-09 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
US20040149283A1 (en) * | 2002-12-12 | 2004-08-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient |
US7284553B2 (en) | 2002-12-12 | 2007-10-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient |
US20050172962A1 (en) * | 2004-02-06 | 2005-08-11 | Microdose Technologies, Inc. | Blister pack for use with an inhalation device |
US20080115784A1 (en) * | 2004-02-24 | 2008-05-22 | Gumaste Anand V | Synthetic jet based medicament delivery method and apparatus |
US8322338B2 (en) | 2004-02-24 | 2012-12-04 | Microdose Therapeutx, Inc. | Synthetic jet based medicament delivery method and apparatus |
US9162031B2 (en) | 2004-02-24 | 2015-10-20 | Microdose Therapeutx, Inc. | Directional flow sensor inhaler |
US7334577B2 (en) | 2004-02-24 | 2008-02-26 | Microdose Technologies, Inc. | Synthetic jet based medicament delivery method and apparatus |
US7779837B2 (en) | 2004-02-24 | 2010-08-24 | Microdose Therapeutx, Inc. | Synthetic jet based medicament delivery method and apparatus |
US9764104B2 (en) | 2004-02-24 | 2017-09-19 | Microdose Therapeutx, Inc. | Directional flow sensor inhaler |
US20100229860A1 (en) * | 2004-02-24 | 2010-09-16 | Gumaste Anand V | Synthetic jet based medicament delivery method and apparatus |
US8474452B2 (en) | 2004-02-24 | 2013-07-02 | Microdose Therapeutx, Inc. | Directional flow sensor inhaler |
WO2005081833A2 (en) | 2004-02-24 | 2005-09-09 | Microdose Technologies, Inc. | Synthetic jet based medicament delivery method and apparatus |
US7318434B2 (en) | 2004-02-24 | 2008-01-15 | Microdose Technologies, Inc. | Synthetic jet based medicament delivery method and apparatus |
US20050183724A1 (en) * | 2004-02-24 | 2005-08-25 | Microdose Technologies, Inc. | Synthetic jet based medicament delivery method and apparatus |
US20060174869A1 (en) * | 2004-02-24 | 2006-08-10 | Gumaste Anand V | Synthetic jet based medicament delivery method and apparatus |
US20050183725A1 (en) * | 2004-02-24 | 2005-08-25 | Microdose Technologies, Inc. | Directional flow sensor inhaler |
EA010922B1 (en) * | 2004-11-10 | 2008-12-30 | Сипла Лимитед | Inhaler |
US8006695B2 (en) | 2004-11-10 | 2011-08-30 | Cipla Limited | Inhaler |
WO2006051300A1 (en) * | 2004-11-10 | 2006-05-18 | Cipla Limited | Inhaler |
US20080105256A1 (en) * | 2004-11-10 | 2008-05-08 | Cipla Limited | Inhaler |
US8662076B2 (en) | 2005-01-11 | 2014-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
US20060157054A1 (en) * | 2005-01-11 | 2006-07-20 | Boehringer Lngelheim Pharma Gmbh & Co. Kg | Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers |
US20100040560A1 (en) * | 2005-05-18 | 2010-02-18 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8524735B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US20080308103A1 (en) * | 2005-05-18 | 2008-12-18 | Airsec S.A.S. | Inhalator Capsules |
US20100037890A1 (en) * | 2005-05-18 | 2010-02-18 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
EP2594272A2 (en) | 2005-05-18 | 2013-05-22 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US10987357B2 (en) | 2005-05-18 | 2021-04-27 | Horizon Orphan, LLC | Aerosolized fluoroquinolones and uses thereof |
US20100158957A1 (en) * | 2005-05-18 | 2010-06-24 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US20100166673A1 (en) * | 2005-05-18 | 2010-07-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8357696B2 (en) | 2005-05-18 | 2013-01-22 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8546423B2 (en) | 2005-05-18 | 2013-10-01 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US8397717B2 (en) | 2005-10-28 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Inhaler with mouthpiece having a microbiological protective function |
US20080295832A1 (en) * | 2005-10-28 | 2008-12-04 | Johannes Geser | Inhaler with Mouthpiece Having a Microbiological Protective Function |
US20070107722A1 (en) * | 2005-11-15 | 2007-05-17 | Hubert Hoelz | Needle for piercing a powder capsule for inhalation |
US9604017B2 (en) | 2005-11-15 | 2017-03-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Needle for piercing a powder capsule for inhalation |
US20070209661A1 (en) * | 2006-03-03 | 2007-09-13 | Hugh Smyth | Dry powder inhaler with aeroelastic dispersion mechanism |
WO2007107160A1 (en) | 2006-03-21 | 2007-09-27 | Bang & Olufsen Medicom A/S | Inhaler flow channel |
EP2357015A2 (en) | 2006-04-05 | 2011-08-17 | MicroDose Therapeutx, Inc. | Variable dose inhalation device |
US20070240712A1 (en) * | 2006-04-05 | 2007-10-18 | Scott Fleming | Variable dose inhalation device |
US20070240713A1 (en) * | 2006-04-11 | 2007-10-18 | Georg Boeck | Inhaler |
US7870856B2 (en) | 2006-04-11 | 2011-01-18 | Boehringer Ingelheim International Gmbh | Inhaler |
US20090320838A1 (en) * | 2006-06-16 | 2009-12-31 | Cipla Limited | Dry powder inhaler |
US8522775B2 (en) * | 2006-06-16 | 2013-09-03 | Cipla Limited | Dry powder inhaler |
US20080163610A1 (en) * | 2007-01-05 | 2008-07-10 | Matthew Thomas Baird | Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle |
US11224704B2 (en) * | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
RU2470680C2 (en) * | 2007-08-01 | 2012-12-27 | Берингер Ингельхайм Интернациональ Гмбх | Inhaler |
US8919342B2 (en) | 2007-08-01 | 2014-12-30 | Boehringer Ingelheim International Gmbh | Inhaler |
CN101815552B (en) * | 2007-08-01 | 2013-03-06 | 贝林格尔.英格海姆国际有限公司 | Inhaler |
WO2009016238A3 (en) * | 2007-08-01 | 2009-05-07 | Boehringer Ingelhelheim Intern | Inhaler |
US20100313886A1 (en) * | 2007-08-01 | 2010-12-16 | Herbert Wachtel | Inhaler |
EP2020249A1 (en) * | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
WO2009016238A2 (en) * | 2007-08-01 | 2009-02-05 | Boehringer Ingelhelheim International Gmbh | Inhaler |
US9132246B2 (en) | 2007-10-09 | 2015-09-15 | Microdose Therapeutx, Inc. | Inhalation device |
US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
US20090090361A1 (en) * | 2007-10-09 | 2009-04-09 | Anand Gumaste | Inhalation device |
US9539400B2 (en) | 2007-10-09 | 2017-01-10 | Microdose Therapeutx, Inc. | Inhalation device |
US9125998B2 (en) | 2008-01-24 | 2015-09-08 | Vectura Delivery Devices Limited | Inhaler |
US20110056488A1 (en) * | 2008-01-24 | 2011-03-10 | Vectura Delivery Devices Limited | Inhaler |
US8371294B2 (en) | 2008-02-29 | 2013-02-12 | Microdose Therapeutx, Inc. | Method and apparatus for driving a transducer of an inhalation device |
US20090217925A1 (en) * | 2008-02-29 | 2009-09-03 | Anand Gumaste | Method and apparatus for driving a transducer of an inhalation device |
WO2009139732A1 (en) * | 2008-05-16 | 2009-11-19 | Bilgic Mahmut | Dry powder inhaler |
US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
US8748488B2 (en) | 2008-05-30 | 2014-06-10 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
US10722519B2 (en) | 2008-10-07 | 2020-07-28 | Horizon Orphan Llc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US8815838B2 (en) | 2008-10-07 | 2014-08-26 | David C. Griffith | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US20100087386A1 (en) * | 2008-10-07 | 2010-04-08 | Mpex Pharmaceuticals, Inc. | Topical use of levofloxacin for reducing lung inflammation |
US9717738B2 (en) | 2008-10-07 | 2017-08-01 | Horizon Orphan Llc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US20100087416A1 (en) * | 2008-10-07 | 2010-04-08 | Mpex Pharmaceuticals, Inc. | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US8629139B2 (en) | 2008-10-07 | 2014-01-14 | Mpex Pharmaceuticals, Inc. | Topical use of Levofloxacin for reducing lung inflammation |
US9326936B2 (en) | 2008-10-07 | 2016-05-03 | Raptor Pharmaceuticals, Inc. | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US10149854B2 (en) | 2008-10-07 | 2018-12-11 | Horizon Orphan Llc | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
US11020481B2 (en) | 2008-10-07 | 2021-06-01 | Horizon Orphan Llc | Topical use of levofloxacin for reducing lung inflammation |
US8985101B2 (en) | 2009-05-21 | 2015-03-24 | Microdose Therapeutx, Inc. | Method and device for clamping a blister within a dry powder inhaler |
US20100294278A1 (en) * | 2009-05-21 | 2010-11-25 | Mosier Kent D | Rotary cassette system for dry powder inhaler |
US8763606B2 (en) | 2009-05-21 | 2014-07-01 | Microdose Therapeutx, Inc. | Rotary cassette system for dry powder inhaler |
US9180263B2 (en) | 2009-07-01 | 2015-11-10 | Microdose Therapeutx, Inc. | Laboratory animal pulmonary dosing device |
US20110000481A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Nebulizer for infants and respiratory compromised patients |
US20110000482A1 (en) * | 2009-07-01 | 2011-01-06 | Anand Gumaste | Laboratory animal pulmonary dosing device |
US9700564B2 (en) | 2009-09-04 | 2017-07-11 | Horizon Orphan Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
US10792289B2 (en) | 2009-09-04 | 2020-10-06 | Horizon Orphan Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
US10231975B2 (en) | 2009-09-04 | 2019-03-19 | Horizon Orphan Llc | Use of aerosolized levofloxacin for treating cystic fibrosis |
US9492625B2 (en) | 2009-11-12 | 2016-11-15 | Stc.Unm | Dry powder inhaler with flutter dispersion member |
US8991390B2 (en) | 2010-01-05 | 2015-03-31 | Microdose Therapeutx, Inc. | Inhalation device and method |
US20110162642A1 (en) * | 2010-01-05 | 2011-07-07 | Akouka Henri M | Inhalation device and method |
US10434267B2 (en) | 2010-01-05 | 2019-10-08 | Microdose Therapeutx, Inc. | Inhalation device and method |
EP3431128A1 (en) | 2010-01-05 | 2019-01-23 | MicroDose Therapeutx, Inc. | Inhalation device and method |
US9974909B2 (en) | 2010-01-05 | 2018-05-22 | Microdose Therapeutx, Inc. | Inhalation device and method |
US8561609B2 (en) | 2010-12-07 | 2013-10-22 | Respira Therapeutics, Inc. | Dry powder inhaler |
US8651104B2 (en) | 2010-12-07 | 2014-02-18 | Respira Therapeutics, Inc. | Bead-containing dry powder inhaler |
EP4059499A1 (en) | 2011-01-31 | 2022-09-21 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US11471623B2 (en) | 2012-02-21 | 2022-10-18 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
US10441733B2 (en) | 2012-06-25 | 2019-10-15 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
EP3782604A1 (en) | 2013-07-31 | 2021-02-24 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
WO2015075433A1 (en) | 2013-11-19 | 2015-05-28 | Cipla Limited | Inhaler device |
US10028966B2 (en) | 2014-01-10 | 2018-07-24 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
WO2015128789A1 (en) | 2014-02-25 | 2015-09-03 | Lupin Limited | Inhaler |
US10556069B2 (en) | 2014-02-25 | 2020-02-11 | Lupin Limited | Inhaler |
WO2015143012A1 (en) | 2014-03-19 | 2015-09-24 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015179369A1 (en) | 2014-05-20 | 2015-11-26 | Infinity Pharmaceuticals, Inc. | Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors |
US20170095625A1 (en) * | 2014-06-04 | 2017-04-06 | Merck Sharp & Dohme Corp. | Dry powder inhaler with dose depletion evaluation |
EP3804794A1 (en) | 2014-07-07 | 2021-04-14 | MicroDose Therapeutx, Inc. | Inhalation device |
WO2016007356A1 (en) | 2014-07-07 | 2016-01-14 | Microdose Therapeutx, Inc. | Inhalation device |
US10744278B2 (en) | 2014-07-07 | 2020-08-18 | Microdose Therapeutx, Inc. | Inhalation device |
WO2016014586A1 (en) | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder medicament de-agglomerator |
WO2016014154A1 (en) | 2014-07-23 | 2016-01-28 | Microdose Therapeutx, Inc. | Dry powder nebulizer |
US10238821B2 (en) | 2016-10-11 | 2019-03-26 | Microdose Therapeutx, Inc. | Inhaler and methods of use thereof |
US20200139057A1 (en) * | 2017-06-27 | 2020-05-07 | Korea United Pharm. Inc. | Dry powder inhaler |
US12053574B2 (en) * | 2017-06-27 | 2024-08-06 | Korea United Pharm. Inc. | Dry powder inhaler with drug inlet mesh network |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
Also Published As
Publication number | Publication date |
---|---|
GB1331216A (en) | 1973-09-26 |
FR2146202A1 (en) | 1973-03-02 |
ATA346473A (en) | 1976-03-15 |
ES208808U (en) | 1976-04-01 |
CA999202A (en) | 1976-11-02 |
AT333415B (en) | 1976-11-25 |
IT941426B (en) | 1973-03-01 |
BE781102A (en) | 1972-07-17 |
ES208808Y (en) | 1976-07-16 |
CH563167A5 (en) | 1975-06-30 |
FR2146202B1 (en) | 1976-01-16 |
NL7305363A (en) | 1974-05-07 |
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