US3795240A - Respiratory distress stimulator system - Google Patents

Respiratory distress stimulator system Download PDF

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Publication number
US3795240A
US3795240A US00239264A US3795240DA US3795240A US 3795240 A US3795240 A US 3795240A US 00239264 A US00239264 A US 00239264A US 3795240D A US3795240D A US 3795240DA US 3795240 A US3795240 A US 3795240A
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United States
Prior art keywords
patient
care system
pneumatic
monitoring
patient care
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Expired - Lifetime
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US00239264A
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English (en)
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U Frank
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F Hoffmann La Roche AG
Kontron Inc
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F Hoffmann La Roche AG
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Assigned to KONTRON INCORPORATED reassignment KONTRON INCORPORATED ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: ROCHE MEDICAL ELECTRONICS INC. A CORP. OF NJ.
Assigned to ROCHE MEDICAL ELECTRONICS INC., A CORP. OF NJ reassignment ROCHE MEDICAL ELECTRONICS INC., A CORP. OF NJ ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: HOFFMANN-LA ROCHE INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H31/00—Artificial respiration by a force applied to the chest; Heart stimulation, e.g. heart massage
    • A61H31/004—Heart stimulation
    • A61H31/005—Heart stimulation with feedback for the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/113—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H1/00—Apparatus for passive exercising; Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
    • A61H1/001—Apparatus for applying movements to the whole body
    • A61H1/003—Rocking or oscillating around a horizontal axis transverse to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H31/00—Artificial respiration by a force applied to the chest; Heart stimulation, e.g. heart massage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H31/00—Artificial respiration by a force applied to the chest; Heart stimulation, e.g. heart massage
    • A61H31/004—Heart stimulation
    • A61H31/006—Power driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H31/00—Artificial respiration by a force applied to the chest; Heart stimulation, e.g. heart massage
    • A61H31/008—Supine patient supports or bases, e.g. improving air-way access to the lungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/12—Driving means
    • A61H2201/1238—Driving means with hydraulic or pneumatic drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/50—Control means thereof
    • A61H2201/5058—Sensors or detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2230/00—Measuring physical parameters of the user
    • A61H2230/40—Respiratory characteristics

Definitions

  • ABSTRACT 52 us. Cl 128/2 R, l28/2.08, 128/28, A 1 Care System for mmitoring respiratory 340/279 tress problems and providing therapeutic treatment [5 1 Int. Cl; A6lb 5/08 comprising a Sensor for generating patient derived [58] Field of searchum 128/2 S, 2 R, 208, 2 A spiratory activity signals, detecting an apnea episode 28/33, 1 340/279 from the signals, and providing in response to a detected apnea episode, stimulation of the patient by a [56] Referen'ces Cited momentary inflation of a pneumatic means adapted UNITED STATES PATENTS for placement under the patient to raise the patient and induce loss of equilibrium for startling the patient 3,2322 131373 37:18:11 into a natural respiration pattem 3,392,723 7/1968 Calvin....
  • the present invention relates to an apnea monitoring and therapeutic system and more specifically a system directed at stimulation of a patient in respiratory distress.
  • apnea The cessation of respiration or the inability to get ones breath often referred to as apnea, is a serious problem which becomes dangerous especially in premature infants where such occurrences are frequent. It is understood that repeated attacks as well as prolonged attacks of apnea are factors which carry a poor prognosis both for life and for subsequent mental development resulting from irreversible cerebral damage sustained during these apneic episodes.
  • the best prospect of reducing harmful effects of late-occurring apnea is through constant surveillance preferably using some automated device to alert attendants so that stimulationthrough resuscitation can-begin promptly. As a consequence, apnea monitoring of premature infants has become an accepted practice in most institutions.
  • Management of apnea monitoring in the newborn, particularly in prematures, for the most part includes sensitive devices for detecting apnea events. Upon detection of an apnea episode a visual or audible alarm is generated, to call the attending nurse for prompt manual stimulation of the infant in an attempt to terminate the episode by restoring normal breathing. Alertness and responsiveness of the nursing staff is important as present embodiment.
  • the apnea monitor 14 could take the configuration of a number of conventional apnea monitors now commercially available irrespective of whether the basis of their operation is based on the impedance pneumography, capacitance respirometry, or any other technique for detecting the apnea episode.
  • a typical one of such apnea monitors is shown in FIG. 2 including, an input amplifier 17 which is driving a Schmitt trigger 18 it becomes more difficult to obtain a positive response to stimulation the longer the apnea persists.
  • most apnea monitors are designed to provide an early alarm. Unfortunately, however, most of these apnea episodes are of a short duration and occur almost randomly during any day of neonatal life. Thus, they place an unnecessary burdenon the nurse to the extent that in some cases it is conceivable that the alarms may even be neglected.
  • the purpose of the present invention is to avoid some i of the problems incurred in apnea monitoring by closing the loop of the automated monitoring system, to
  • FIG. 1 is a schematic diagram in block form, of the invention.
  • FIG. 2 is a schematic diagram in block form of a typical apnea monitor 14 illustrated in FIG. 1.
  • FIG. 3 is a top plan view of one embodiment of'a pneumatic stimulator 25 shown in FIG. 1.
  • FIG. 4 is a schematic diagram in block form of a preferred embodiment of the pneumatic supply unit 24 depicted in FIG. 1.
  • the Schmitt trigger output is connected to a timer 19 having a timing capacitance which will react in response to a predetermined interval for denoting an apnea interval to in turn produce an output for exciting an alarm latch 21, the output of which is connected to the one shot unit 16, illustrated in FIG. 1.
  • the Schmitt-trigger 18 output is also used for energizing a one shot unit 22 which in turn drives an indicator 23 representative of the respiration activity of the patient. 1 v
  • the duration of the one shot timer 16 will determine the period during which stimulation is to be applied to the patient.
  • the one shot timer 16 is connected for driving a pneumatic supply unit which in turn is pneumatically coupled through suitable tubing to an inflatable pneumatic stimulator 25placed under the patient.
  • the pneumatic stimulator is momentarily inflated to induce a sudden loss of equilibrium which, in effect, startles the patient back into a normal respiration pattern.
  • FIG. 3 An embodiment of the pneumatic stimulator is illustrated in FIG. 3, wherein there is a rectangular shaped flexible casing constructed of, for example, an elastomeric material which might be rubber; neoprene, polyethelene etc.
  • the pneumatic stimulator has an air mattress configuration provided by four partially separated areas 27 each of which is supplied with air through a relatively rigid tube 28 via apertures 29.
  • the rigid tube is advantageous in that because of its rigid nature the air mattress cannot be folded or bent over at an area where one depends on the passage of air through the several segments for proper air flow. Otherwise, as is experienced with conventional air mattresses, when folded over the continuity of air flow is obstructed between adjacent segments to prevent the air mattress from being completely inflated.
  • the height of the mattress when fully inflated can be better regulated over the entire areaof the mattress, and thus prevent the pneumatic stimulator from billowing up when'inflated to otherwise possibly cause the patient to be moved to one side.
  • a normal size of the air mattress for an infant might be about 5 by 8 inches to allow for considerable movement of the neonate without having the head and neck slide off when used under the head and neck.
  • FIG. 4 An embodiment of the pneumatic supply unit 24, is shown in FIG. 4, wherein the input signal from one shot 16 is connected to a relay unit 31 which controls a relay arm 32 to be either connected to a first terminal (a) denoted as a non-apnea terminal or a second terminal (b) denoted as an apnea terminal.
  • the relay arm 32 In its normally assumed position the relay arm 32 is connected to terminal (a) which, in turn, is connected to a pressure switch 38, that is connected via pneumatic tubing from a gas reservoir 33, preferably air, which is electrically connected to a pump 34.
  • Air reservoir 33 and pump 34 are also pneumatically connected via a flapper valve 35.
  • the pressure switch 38 senses the pressure in air reservoir 33 which, if below a predetermined pressure valve, will be supplied with pressurized air from pump 34 through one-way flapper valve 35.
  • the terminal point (b) of relay 31 is connected via an apnea lead to a counter 36 and to a three-way solenoid valve 37, which is pneumatically coupled from air reservoir 33 to the pneumatic stimulator 25 and through an exhaust opening.
  • Reservoir 33 assures the availability of a large quantity of pressurized air to momentarily inflate the pneumatic stimulator, and also avoids delay during the inflation cycle of the pneumatic stimulator.
  • the time to inflate the pneumatic stimulator takes less than one-half second assuming a psi reservoir pressure source and 54 inch diameter connecting tube with a final 4 psi system pressure, including the stimulator.
  • relay arm 31 is normally connected to the (a) terminal, pump 34 will be charging air reservoir 33 through the flapper valve 35 during periods when the pressure switch 38 senses approximately 10 percent below a predetermined pressure for the air reservoir. Respiratory movements which are detected by senspr 1 l are fed to the apnea monitor 14. Upon detection of an apnea episode the one shot timer 16 is activated.
  • Relay 31 is activated from the one shot unit 16 for a period of one second during which time relay arm 32 enables power to be supplied to the three-way solenoid valve and an apnea episode count is made on counter 36.
  • the three-way solenoid valve is open allowing the air from reservoir 33 to momentarily inflate pneumatic stimulator 25 to stimulate the patient by suddenly raising the patient up in the air to introduce his sudden loss of equilibrium and, in effect, startle the patient into normal respiration.
  • relay arm 32 goes back to terminal (12) to, in effect, close off the three-way solenoid valve from air reservoir 33 to pneumatic stimulator 25 and open the exhaust opening of the three-way valve to the pneumatic stimulator 25 for deflating the pneumatic stimulator.
  • a continuing alarm might be provided for until the patient is attended to or a second nurses alarm might be initiated within a5- second period or any other prescribed time period that would be suitable for providing such a second alarm.
  • a patient care system for monitoring and treating respiratory distress problems comprising:
  • stimulating means responsive to said detecting means including inflatable fluid means adapted for placement under a patient to cause a loss of patient equilibrium, by a startling momentary raising action of a non-oscillatory type.
  • said stimulating means further includes fluid supply means electrically connected from said detecting means andadapted for momentarily inflating said pneumatic means.
  • a patient care system according to claim 2 wherein said fluid supply means includes air reservoir means for maintaining a predetermined air pressure value for inflating the fluid means.
  • a patient care system including means responsive to said detecting means for counting each respiratory distress problem detected.
  • a patient care system for monitoring and treating respiratory distress problems comprising:
  • monitoring means responsive to said respiratory activity signals for providing an output signal upon detection of a respiratory distress problem
  • inflatable pneumatic means including an air mattress adapted for placement under a patient
  • pneumatic supply means including air reservoir means for maintaining a predetermined air pressure valve, energizable to inflate said pneumatic means;'and 1 means of a non-oscillatory type, responsive to said monitoring means outputsignal, for momentarily energizing said pneumatic supply means to provide a startling raising action adapted to cause a loss of patient equilibrium.
  • said pneumatic supply means further includes: valve means; an energizable pump connected to said air reservoir through said valve means; and, a pressure switch when activated responsive to less than a predetermined level of air pressure in said air reservoir means for energizing said pump.
  • a patient care system including switch means connected from the monitoring means for activating said pressure switch in the absence of an output signal from said monitoring means.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Rehabilitation Therapy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
US00239264A 1972-03-29 1972-03-29 Respiratory distress stimulator system Expired - Lifetime US3795240A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23926472A 1972-03-29 1972-03-29
NL7402202A NL7402202A (nl) 1972-03-29 1974-02-18 Inrichting voor het controleren en behandelen van ademhalingsstoringen.
GB734374A GB1436032A (en) 1972-03-29 1974-02-18 Respiratory distress stimulator
DE19742408179 DE2408179A1 (de) 1972-03-29 1974-02-20 Vorrichtung zur atmungsstimulation bei apnoe
FR7405743A FR2260987A1 (enrdf_load_stackoverflow) 1972-03-29 1974-02-20

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US00239264A Expired - Lifetime US3795240A (en) 1972-03-29 1972-03-29 Respiratory distress stimulator system

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US (1) US3795240A (enrdf_load_stackoverflow)
DE (1) DE2408179A1 (enrdf_load_stackoverflow)
FR (1) FR2260987A1 (enrdf_load_stackoverflow)
GB (1) GB1436032A (enrdf_load_stackoverflow)
NL (1) NL7402202A (enrdf_load_stackoverflow)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3870012A (en) * 1972-10-16 1975-03-11 Robert Metivier Pressure drop alarm device
US3882847A (en) * 1973-12-11 1975-05-13 Harvey Barry Jacobs Low-Cost Pneumatic Apnea or Respiration Monitor
US3942513A (en) * 1972-03-29 1976-03-09 Hoffmann-La Roche Inc. Respiratory distress stimulator system
US4163449A (en) * 1977-09-30 1979-08-07 Regal Robert A Enuresis treatment device
US4311146A (en) * 1980-05-08 1982-01-19 Sorenson Research Co., Inc. Detachable balloon catheter apparatus and method
US4381788A (en) * 1981-02-27 1983-05-03 Douglas David W Method and apparatus for detecting apnea
US4657025A (en) * 1981-12-09 1987-04-14 Carl Orlando Heart and breathing alarm monitor
US4860766A (en) * 1983-11-18 1989-08-29 Respitrace Corp. Noninvasive method for measuring and monitoring intrapleural pressure in newborns
US5081447A (en) * 1990-10-19 1992-01-14 Echols Wilford R Keep off your back alarm
US5277194A (en) * 1989-01-31 1994-01-11 Craig Hosterman Breathing monitor and stimulator
US5611349A (en) * 1993-04-26 1997-03-18 I Am Fine, Inc. Respiration monitor with simplified breath detector
CN107126610A (zh) * 2017-06-08 2017-09-05 青岛大学附属医院 一种智能呼吸机

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477013A1 (fr) * 1980-02-29 1981-09-04 Inst Nat Sante Rech Med Appareil pour la stimulation du rythme ventilatoire des prematures
DE3146628C2 (de) * 1981-11-25 1991-03-28 Dornier System Gmbh, 7990 Friedrichshafen Auslösevorrichtung für Stoßwellen zu therapeutischen Zwecken
US5395301A (en) * 1992-03-30 1995-03-07 Russek; Linda G. Kinesthetic system for promoting rhythmic breathing by tactile stimulation
DE29622321U1 (de) * 1996-12-21 1997-03-06 Medicap Medizintechnik GmbH, 35327 Ulrichstein Einrichtung zur dosierten Gasversorgung von Anwendern
DE19716166A1 (de) * 1997-04-18 1998-10-22 Meier Bernd Horst Dr Verfahren und Vorrichtung zur Steuerung und Unterstützung natürlicher Atmung und künstlicher Beatmung

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776658A (en) * 1953-06-02 1957-01-08 Air Shields Rocking bed construction
US3085568A (en) * 1960-08-02 1963-04-16 Whitesell Harry Physio-therapy apparatus
US3392723A (en) * 1965-08-09 1968-07-16 Richfield Oil Corp Electro-pneumatically operated bed oscillator
US3547106A (en) * 1968-01-08 1970-12-15 American Electronic Lab Activity detecting means
US3566387A (en) * 1967-11-14 1971-02-23 Mine Safety Appliances Co Monitoring device for positive pressure breathing apparatus
US3631438A (en) * 1968-10-31 1971-12-28 Nat Res Dev Apnoea alarms
US3672354A (en) * 1970-09-04 1972-06-27 Scovill Manufacturing Co Rest-inducing device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776658A (en) * 1953-06-02 1957-01-08 Air Shields Rocking bed construction
US3085568A (en) * 1960-08-02 1963-04-16 Whitesell Harry Physio-therapy apparatus
US3392723A (en) * 1965-08-09 1968-07-16 Richfield Oil Corp Electro-pneumatically operated bed oscillator
US3566387A (en) * 1967-11-14 1971-02-23 Mine Safety Appliances Co Monitoring device for positive pressure breathing apparatus
US3547106A (en) * 1968-01-08 1970-12-15 American Electronic Lab Activity detecting means
US3631438A (en) * 1968-10-31 1971-12-28 Nat Res Dev Apnoea alarms
US3672354A (en) * 1970-09-04 1972-06-27 Scovill Manufacturing Co Rest-inducing device

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3942513A (en) * 1972-03-29 1976-03-09 Hoffmann-La Roche Inc. Respiratory distress stimulator system
US3870012A (en) * 1972-10-16 1975-03-11 Robert Metivier Pressure drop alarm device
US3882847A (en) * 1973-12-11 1975-05-13 Harvey Barry Jacobs Low-Cost Pneumatic Apnea or Respiration Monitor
US4163449A (en) * 1977-09-30 1979-08-07 Regal Robert A Enuresis treatment device
US4311146A (en) * 1980-05-08 1982-01-19 Sorenson Research Co., Inc. Detachable balloon catheter apparatus and method
US4381788A (en) * 1981-02-27 1983-05-03 Douglas David W Method and apparatus for detecting apnea
US4657025A (en) * 1981-12-09 1987-04-14 Carl Orlando Heart and breathing alarm monitor
US4860766A (en) * 1983-11-18 1989-08-29 Respitrace Corp. Noninvasive method for measuring and monitoring intrapleural pressure in newborns
US5277194A (en) * 1989-01-31 1994-01-11 Craig Hosterman Breathing monitor and stimulator
US5081447A (en) * 1990-10-19 1992-01-14 Echols Wilford R Keep off your back alarm
US5611349A (en) * 1993-04-26 1997-03-18 I Am Fine, Inc. Respiration monitor with simplified breath detector
CN107126610A (zh) * 2017-06-08 2017-09-05 青岛大学附属医院 一种智能呼吸机
CN107126610B (zh) * 2017-06-08 2019-08-06 青岛大学附属医院 一种智能呼吸机

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Publication number Publication date
DE2408179A1 (de) 1975-08-21
NL7402202A (nl) 1975-08-20
GB1436032A (en) 1976-05-19
FR2260987A1 (enrdf_load_stackoverflow) 1975-09-12

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Owner name: KONTRON INCORPORATED, EVERETT, MASS. A CORP. OF DE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:ROCHE MEDICAL ELECTRONICS INC. A CORP. OF NJ.;REEL/FRAME:004011/0651

Effective date: 19820526

Owner name: ROCHE MEDICAL ELECTRONICS INC., A CORP. OF NJ, NEW

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HOFFMANN-LA ROCHE INC.;REEL/FRAME:004048/0917

Effective date: 19820525

Owner name: ROCHE MEDICAL ELECTRONICS INC., NUTLEY, NJ A CORP.

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:HOFFMANN-LA ROCHE INC.;REEL/FRAME:004048/0917

Effective date: 19820525