US3733716A - Lyophilization installation - Google Patents

Lyophilization installation Download PDF

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Publication number
US3733716A
US3733716A US00148009A US3733716DA US3733716A US 3733716 A US3733716 A US 3733716A US 00148009 A US00148009 A US 00148009A US 3733716D A US3733716D A US 3733716DA US 3733716 A US3733716 A US 3733716A
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US
United States
Prior art keywords
vessel
plate
disposed
plate means
installation according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00148009A
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English (en)
Inventor
R Bonteil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Electric Works Co Ltd
Original Assignee
Matsushita Electric Works Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsushita Electric Works Ltd filed Critical Matsushita Electric Works Ltd
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Publication of US3733716A publication Critical patent/US3733716A/en
Anticipated expiration legal-status Critical
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • Cited vessel is constructed to define, above the plate, an increasing flow cross-section for vapors liberated from UNITED STATES PATENTS the particles of the product.
  • a conventional lyophilization installation has a vacuum vessel inside which the particles of a product to be lyophilized are dried on a vibrating plate, and it frequently occurs that the particles of the product, particularly the smallest particles, are carried in the flow of water vapor from the vibrating plate and are lost, which obviously reduces the yield of the lyophilization installation.
  • These particles of the product leaving the vibrating plate are not necessarily entrained in the flow of water vapor towards a stream trap, but, most frequently, are deposited on the inside walls of the vacuum vessel so that it is necessary for the vacuum vessel to be periodically cleaned.
  • the present invention seeks to overcome these disadvantages of the conventional lyophilization installations.
  • a lyophilization installation comprising a vacuum vessel, a plate rigidly fixed inside the vessel and upon which, in operation, a vibration bed is produced and particles of a product to be lyophilized are dried, and vibration means for vibrating the vessel as a whole.
  • the particles of the product which are carried in the flow of vapor and are deposited on the inside walls of the vacuum vessel automaticall'y fall back onto the plate as a result of the vibration of the vessel Moreover, as it is not essential to provide the vibration means inside the vessel, as in the conventional lyophilization installation, the construction of the vessel is far simpler and a larger space remains therein available for the particles of the product and associated equipment such as, for example, heating elements.
  • the vacuum vessel is, preferably, so constructed as to define, above the plate, an increasing flow crosssection for vapor liberated from the particles of the product.
  • Vacuum vessels used at the present time are gener ally cylindrical in form and disposed horizontally, so that the plate may be placed in the bottom part of the vessel. It will be noted that the arrangement of the plate in the bottom part of the vessel is greatly facilitated by the fact that the vibration means need not necessarily be positioned with-in the vessel.
  • the particles of the product which are carried in the flow of vapor undergo an abrupt drop in speed and tend to fall back or return onto the plate by the action of gravity, or else are deposited on the walls of the vessel from which they return to the plate by the vibration of the vessel.
  • FIG. 1 is an elevational and partly broken away view of a lyophilization installation according to the present invention.
  • FIG. 2 is a sectional viewon the line II-II of the lyophilization installation of FIG. 1.
  • a lyophilization installation according to the present invention and illustrated in the drawings is designed for the continuous treatment of a product (more particularly, although not so restricted, a food product) which has previously been frozen and divided into fine particles.
  • the installation comprises a vacuum vessel 1 of cylindrical shape and horizontally disposed. Inside the vessel 1 there is rigidly fixed a horizontal plate 2 adapted to support the particles of the product.
  • the plate 2 is disposed in the bottom part of the vessel 1 and is rigidly connected to the side walls thereof by inclined ribs or rims 3 the purpose of which will be appreciated from the discussion given hereinafter.
  • the frozen particles of the product to be lyophilized or dried are introduced into the vessel 1 through an inlet 4 and pass through a screen (not shown) and are discharged from the vessel through another screen (also not shown) and an outlet 5.
  • the vessel 1 rests on the ground by four feet 6 provided with elastic suspension elements 7 and is vibrated by external means (not shown) which may, for example, be motors with out-of-balance weights.
  • the vibrations to which the vessel 1 is subjected are such that the particles of the product deposited on the plate 2 are transported from upstream (i.e. adjacent the inlet 4) to downstream (i.e. adjacent the outlet 5) in the form of a vibrating or fluidized bed 8.
  • These two heating plates are rigidly connected to fixed supports 11 by uprights 12 which pass through the walls of the vessel 1 in flexible connections 13 to ensure airtightness of the vessel.
  • the water'vapor, freed from the particles of the product during its drying, is discharged through a top opening 14 also provided with a flexible connection 15, passing to a steam trap or condenser (not shown).
  • a lyophilization installation comprising:
  • wall means defining a vessel having a substantially closed vacuum chamber, said wall means including rigidly interconnected top, bottom, side and end wall portions; plate means disposed within said vacuum chamber and rigidly fixed to said wall means, said plate means during operation of said installation defining a vibration bed for product particles to be dried;
  • inlet means associated with said wall means and communicating with said plate means adjacent one end thereof for permitting product particles to be supplied to said plate means;
  • outlet means associated with said wall means and disposed adjacent the other end of said plate means for permitting the dried particles to be removed from said vacuum chamber;
  • vibration means operatively interconnected to said wall means for vibrating said vessel as a whole together with the plate means rigidly fixed thereto; vacuum means disposed externally of said vessel; and conduit means operatively connected between said vacuum means and said vessel for permitting creation of at least a partial vacuum within said chamher.
  • said vessel includes an elongated substantially cylindrical wall member disposed with its longitudinal axis extending substantially horizontally and defining the top, bottom and side wall portions of said vessel.
  • conduit means is connected to said cylindrical wall member adjacent the upper portion thereof at a location disposed substantially midway between the inlet and outlet end of said plate means, and said conduit means including flexible connecting means associated therewith for permitting said vessel to be vibrated as a whole while preventing said vibration from being transmitted through said conduit means to said vacuum means.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
US00148009A 1970-06-02 1971-05-28 Lyophilization installation Expired - Lifetime US3733716A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7020098A FR2093088A5 (enrdf_load_stackoverflow) 1970-06-02 1970-06-02

Publications (1)

Publication Number Publication Date
US3733716A true US3733716A (en) 1973-05-22

Family

ID=9056510

Family Applications (1)

Application Number Title Priority Date Filing Date
US00148009A Expired - Lifetime US3733716A (en) 1970-06-02 1971-05-28 Lyophilization installation

Country Status (10)

Country Link
US (1) US3733716A (enrdf_load_stackoverflow)
AU (1) AU2961671A (enrdf_load_stackoverflow)
BE (1) BE767364A (enrdf_load_stackoverflow)
CH (1) CH523482A (enrdf_load_stackoverflow)
DE (1) DE2124097A1 (enrdf_load_stackoverflow)
FR (1) FR2093088A5 (enrdf_load_stackoverflow)
GB (1) GB1285676A (enrdf_load_stackoverflow)
LU (1) LU63189A1 (enrdf_load_stackoverflow)
NL (1) NL7106865A (enrdf_load_stackoverflow)
OA (1) OA03724A (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4357760A (en) * 1981-02-02 1982-11-09 General Kinematics Corporation Apparatus for drying pulverulent material
US4611469A (en) * 1977-01-21 1986-09-16 General Kinematics Method and apparatus for cooling foundry sand
CN102865723A (zh) * 2011-07-07 2013-01-09 江苏申久化纤有限公司 一种真空干燥装置及干燥方法
CN109229910A (zh) * 2018-07-03 2019-01-18 柳州市钜嘉机械有限公司 一种便于运输电机的工装

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197328A (en) * 1961-11-15 1965-07-27 Boeing Co Fluidized bed generated by vibratory means
US3230633A (en) * 1961-10-27 1966-01-25 Pennsalt Chemicals Corp Freeze drying apparatus and method
US3289314A (en) * 1962-12-19 1966-12-06 Edwards High Vacuum Int Ltd Freeze drying
US3465452A (en) * 1966-12-23 1969-09-09 Afico Sa Cryodesiccation apparatus
US3521373A (en) * 1967-07-20 1970-07-21 Vincenzo Pagnozzi Process and plant for the vacuum drying of wood in the form of planks or laths
US3616542A (en) * 1969-02-24 1971-11-02 Earl L Rader Apparatus and processes for producing freeze dried products

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3230633A (en) * 1961-10-27 1966-01-25 Pennsalt Chemicals Corp Freeze drying apparatus and method
US3197328A (en) * 1961-11-15 1965-07-27 Boeing Co Fluidized bed generated by vibratory means
US3289314A (en) * 1962-12-19 1966-12-06 Edwards High Vacuum Int Ltd Freeze drying
US3465452A (en) * 1966-12-23 1969-09-09 Afico Sa Cryodesiccation apparatus
US3521373A (en) * 1967-07-20 1970-07-21 Vincenzo Pagnozzi Process and plant for the vacuum drying of wood in the form of planks or laths
US3616542A (en) * 1969-02-24 1971-11-02 Earl L Rader Apparatus and processes for producing freeze dried products

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4611469A (en) * 1977-01-21 1986-09-16 General Kinematics Method and apparatus for cooling foundry sand
US4357760A (en) * 1981-02-02 1982-11-09 General Kinematics Corporation Apparatus for drying pulverulent material
CN102865723A (zh) * 2011-07-07 2013-01-09 江苏申久化纤有限公司 一种真空干燥装置及干燥方法
CN102865723B (zh) * 2011-07-07 2015-09-16 江苏申久化纤有限公司 一种真空干燥装置的干燥方法
CN109229910A (zh) * 2018-07-03 2019-01-18 柳州市钜嘉机械有限公司 一种便于运输电机的工装

Also Published As

Publication number Publication date
FR2093088A5 (enrdf_load_stackoverflow) 1972-01-28
LU63189A1 (enrdf_load_stackoverflow) 1972-03-03
BE767364A (fr) 1971-11-19
AU2961671A (en) 1972-12-07
DE2124097A1 (de) 1971-12-09
CH523482A (fr) 1972-05-31
NL7106865A (enrdf_load_stackoverflow) 1971-12-06
OA03724A (fr) 1971-12-24
GB1285676A (en) 1972-08-16

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