US3732170A - Bio-soaking performances - Google Patents
Bio-soaking performances Download PDFInfo
- Publication number
- US3732170A US3732170A US00266261A US3732170DA US3732170A US 3732170 A US3732170 A US 3732170A US 00266261 A US00266261 A US 00266261A US 3732170D A US3732170D A US 3732170DA US 3732170 A US3732170 A US 3732170A
- Authority
- US
- United States
- Prior art keywords
- enzyme
- sodium
- salt
- detergent
- triple salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002791 soaking Methods 0.000 title description 6
- 150000003839 salts Chemical class 0.000 abstract description 39
- 239000000203 mixture Substances 0.000 abstract description 37
- 102000004190 Enzymes Human genes 0.000 abstract description 29
- 108090000790 Enzymes Proteins 0.000 abstract description 29
- 229910052783 alkali metal Inorganic materials 0.000 abstract description 10
- 150000001340 alkali metals Chemical class 0.000 abstract description 9
- 108090000787 Subtilisin Proteins 0.000 abstract description 7
- 239000007800 oxidant agent Substances 0.000 abstract description 7
- 230000002797 proteolythic effect Effects 0.000 abstract description 7
- HJKYXKSLRZKNSI-UHFFFAOYSA-I pentapotassium;hydrogen sulfate;oxido sulfate;sulfuric acid Chemical compound [K+].[K+].[K+].[K+].[K+].OS([O-])(=O)=O.[O-]S([O-])(=O)=O.OS(=O)(=O)O[O-].OS(=O)(=O)O[O-] HJKYXKSLRZKNSI-UHFFFAOYSA-I 0.000 abstract description 4
- 239000003599 detergent Substances 0.000 description 30
- 229940088598 enzyme Drugs 0.000 description 27
- -1 colleginase Proteins 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 238000004140 cleaning Methods 0.000 description 13
- 108091005804 Peptidases Proteins 0.000 description 9
- 102000035195 Peptidases Human genes 0.000 description 9
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- 235000019832 sodium triphosphate Nutrition 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 125000000129 anionic group Chemical group 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 150000002927 oxygen compounds Chemical class 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 159000000000 sodium salts Chemical class 0.000 description 5
- 230000003381 solubilizing effect Effects 0.000 description 5
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 150000001642 boronic acid derivatives Chemical class 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000007859 condensation product Substances 0.000 description 3
- 125000003438 dodecyl group Chemical class [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000001165 hydrophobic group Chemical group 0.000 description 3
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- 235000021286 stilbenes Nutrition 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- 239000012425 OXONE® Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
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- 102000005158 Subtilisins Human genes 0.000 description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 150000003841 chloride salts Chemical class 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 235000007686 potassium Nutrition 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 description 2
- 239000011736 potassium bicarbonate Substances 0.000 description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 150000004760 silicates Chemical class 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 229960001922 sodium perborate Drugs 0.000 description 2
- 239000012418 sodium perborate tetrahydrate Substances 0.000 description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 description 2
- 235000011152 sodium sulphate Nutrition 0.000 description 2
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- JNYAEWCLZODPBN-KVTDHHQDSA-N (2r,3r,4r)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@@H](O)[C@H]1O JNYAEWCLZODPBN-KVTDHHQDSA-N 0.000 description 1
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- NFAOATPOYUWEHM-UHFFFAOYSA-N 2-(6-methylheptyl)phenol Chemical compound CC(C)CCCCCC1=CC=CC=C1O NFAOATPOYUWEHM-UHFFFAOYSA-N 0.000 description 1
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- JTNCEQNHURODLX-UHFFFAOYSA-N 2-phenylethanimidamide Chemical compound NC(=N)CC1=CC=CC=C1 JTNCEQNHURODLX-UHFFFAOYSA-N 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 108010059345 keratinase Proteins 0.000 description 1
- 230000002366 lipolytic effect Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 125000005528 methosulfate group Chemical group 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- FZKBJGTWWCHZRN-UHFFFAOYSA-N n-ethyl-n-hydroxydodecanamide Chemical class CCCCCCCCCCCC(=O)N(O)CC FZKBJGTWWCHZRN-UHFFFAOYSA-N 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 235000019353 potassium silicate Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 229940071207 sesquicarbonate Drugs 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical class CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 1
- DZCAZXAJPZCSCU-UHFFFAOYSA-K sodium nitrilotriacetate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O DZCAZXAJPZCSCU-UHFFFAOYSA-K 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 235000019351 sodium silicates Nutrition 0.000 description 1
- DHQIJSYTNIUZRY-UHFFFAOYSA-M sodium;2,3-di(nonyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CCCCCCCCC)C(CCCCCCCCC)=CC2=C1 DHQIJSYTNIUZRY-UHFFFAOYSA-M 0.000 description 1
- IBDSNZLUHYKHQP-UHFFFAOYSA-N sodium;3-oxidodioxaborirane;tetrahydrate Chemical compound O.O.O.O.[Na+].[O-]B1OO1 IBDSNZLUHYKHQP-UHFFFAOYSA-N 0.000 description 1
- MWZFQMUXPSUDJQ-KVVVOXFISA-M sodium;[(z)-octadec-9-enyl] sulfate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCCOS([O-])(=O)=O MWZFQMUXPSUDJQ-KVVVOXFISA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000271 synthetic detergent Substances 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Chemical class OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 229940087291 tridecyl alcohol Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 125000002948 undecyl group Chemical class [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38609—Protease or amylase in solid compositions only
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/39—Organic or inorganic per-compounds
- C11D3/3942—Inorganic per-compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Detergent Compositions (AREA)
Abstract
BIOLOGICAL CLEEANING COMPOSITION CONTTAINING AN ENZYME AND, AS AN OXIDIZING AGENT, AN ALKALI-METAL MONOPERSULFATE TRIPLE SALT. PREFERRED ENZYMES ARE PROTEOLYTIC SUBTILISIN ENZYMEA. A PREFERRED MONOSULFATE TRIPLE SALT IS
(2KHSO5.KHSO4.K2SO4)
(2KHSO5.KHSO4.K2SO4)
Description
United States Patent 6 m 3,732,170 BIO-SOAKING PERFORMANCES Yvon Demangeon, Ermont, France, assignor to Colgate- Palmolive Company, New York, N.Y.
No Drawing. Continuation of application Ser. No. 75,716, Sept. 25, 1970. This application June 26, 1972, Ser. No. 266,261
Int. Cl. Clld 7/54 US. Cl. 252-95 4 Claims ABSTRACT OF THE DISCLOSURE Biological cleaning composition containing an enzyme and, as an oxidizing agent, an alkali-metal monopersulfate triple salt. Preferred enzymes are proteolytic subtilisin enzymes. A preferred monosulfate triple salt is This is a continuation of application, Ser. No. 75,716 filed Sept. 25, 1970, now abandoned.
This invention relates to a biological enzyme composition containing an enzyme and an oxidizing agent.
Cleaning preparations including enzymes have been used with oxidizing agents. Sodium perborate has been generally used. Other oxidizing agents have been suggested, but they have not been favored because of lack of stability or poorer cleaning capability than sodium perborate.
It is an object of this invention to provide a biological cleaning composition containing a stable oxidizing agent which is a superior biological detergent in cleaning capability, particularly in the cleaning of proteinic blood stains.
Other objects will be apparent from consideration of the specification.
In accordance with cermtain of its aspects, this invention relates to a biological cleaning composition containing a proteolytic enzyme and an alkali-metal monopersulfate triple salt.
The proteolytic enzymes which are employed in the instant invention are active upon protein matter and catalyze digestion or degradation of such matter when present as in linen or fabric stain in a hydrolysis reaction. The enzymes are effective at a pH range of 4-12, such as usually prevails in detergent cleaning procedures. Moreover, they may be effective even at moderately high temperatures so long as the temperature does not degrade them. Some proteolytic enzymes are eifective at up to 70 C. and higher. They are also eifective at ambient temperature and lower to about 20 C. Particular examples of proteolytic enzymes which may be used in the instant invention include pepsin, trypsin, chymotrypsin, papain, bromelin, colleginase, keratinase, carboxylase, amino peptidase, elastase, subtilisin, and aspergillopepidase A and B. Preferred enzymes are subtilisin enzymes manufactured and cultivated from special strains of spore-forming bacteria, particularly Bacillus subtilis. Furthermore, it is preferred that the enzyme be substantially free from sulfhydryl groups or disulfide bonds which may inhibit some of the active oxygen of the oxidizing agent.
Metalloproteases which contain divalent ions, such as calcium, magnesium or zinc, bound to their protein chains are of particular interest.
It is within the scope of this invention to use other enzymes which have amylolytic or lipolytic activity to- 3,732,170 Patented May 8, 1973 ice gether with the proteolytic enzyme or to use an enzyme which contains such other activity together with proteolytic activity.
The enzyme preparations are generally extremely fine, often substantially i-mpalpable, powders. In a typical powdered enzyme preparation, the particle diameter is mainly below 0.15 mm., generally above 0.01 mm., e.g., about 0.1 mm. For example, as much as 75% of the material may be 0.149 mm. or smaller. On the other hand, the spray-dried granules are usually of very much larger particle size, with the major portion of the granules being at least about 0.2 mm. in diameter, e.g., about 0.3 or 0.4, or even 0.5, 1 or 2 mm.
The enzyme preparations are generally diluted with salts such as calcium sulfate and inert materials. Chemically, they are typically stable in the pH of about 6 to 11, and at an alkaline pH of about 8.5 to 10 they can withstand temperatures of about 50 C. to C. with relatively little decomposition for time periods varying from 2 hours at the higher temperatures to more than 1 day at the lower temperatures. Different proteolytic enzymes have different degrees of effectiveness in aiding in the removal of stains from textiles and linen.
The alkali-metal (that is, lithium, sodium, potassium, and ammonium) monopersulfate triple salts used in practice of the instant invention are particularly desirable since other alkali-metal monopersulfate salts are not sufiiciently stable to produce desirable cleaning with the enzyme and other alkali-metal persulfate salts, such as the dipersulfates, are far inferior to the monopersulfate triple salt in cleaning effectiveness.
The preferred active oxygen compound, potassium monopersulfate triple salt, available commercially under the trademark Oxone, can be prepared with potassium monopersulfate, potassium bisulfate, and potassium sulfate as a triple salt with a mole ratio of constituents of about 2:1:1, that is, [ZKHSO -KHSO -K SO About 50% by weight of the triple salt is the active oxygen compound, potassium monopersulfate. When the triple salt is added to water, a pH of about 2-3 is obtained. A convenient method for preparing the triple salt is to react a mixture of monopersulfuric acid and a sulfuric acid with an alkali metal carbonate or hydroxide and drying the triple salt reaction product.
The active oxygen content of the alkali metal monopersulfate triple salt is about 5% by weight. A preferred range of proportions of the monopersulfate triple salt is one which provides an active oxygen concentration of about 1-50 p.p.m., more preferably 3-25 p.p.m., for example, 5-15 p.p.m., of active oxygen to wash water. The proportions of salt can, therefore, be readily calculated if one knows how much of total formulation is to be added to wash water. Detergent formulations may be designed for use in proportion of about 0.2-05% for soaking in water or about O-'1 10.2 or 0.3-1% for washing in water.
The enzyme concentration can be varied widely. Typically, an enzyme having a proteolytic activity of about 1.5 Anson units per gram is present in amount which provides about 1 to 40 p.p.m., more preferably about 28 p.p.m. of the enzyme in the wash Water. The optimum proportion of enzyme to be used in a detergent composition containing triple salt will, of course, depend upon the effective enzyme content of the enzyme preparation. As with triple salt content, the quantity of enzyme to be used for stains susceptible to enzyme action will be dependent upon a number of factors, particularly time, temperature, and proportions of triple salt.
The enzyme and triple salt may be used together, as in the Water used for a pre-rinse of the soiled clothes, without any surface-active detergent being present. It is preferable, however, to mix these ingredients into a surfaceactive detergent composition, such as a heavy-duty built granular detergent composition or more preferably in a soaking detergent composition.
The surface active agent which may be employed may be any commonly used compound having surface active or detergent properties. Most preferred are those water-soluble surface active compounds having an anionic or nonionic properties. Anionic surface active agents include those surface active or detergent compounds which contain an organic hydrophobic group and an anionic solubilizing group. Typical examples of anionic solubilizing groups are sulfonate, sulfate, carboxylate, and phosphate. Examples of suitable anionic detergents which fall within the scope of the invention include the soaps, such as the water-soluble salts of higher fatty acids or rosin acids, such as may be derived from fats, oils and waxes of animal, vegetable or marine origin, e.g., the sodium soaps of tallow, grease, coconut oil, tall oil, and mixtures thereof, and the sulfated and sulfonated synthetic detergents, particularly those having about 8 to 26, and preferably 12 to 22, carbon atoms to the molecule.
As examples of suitable synthetic anionic detergents, there may be cited the higher alkyl mononuclear aromatic sulfonates, such as the higher alkyl benzene sulfonates, containing from to 16 carbon atoms in the alkyl group in a straight or branched chain, e.g., the sodium salts of decyl, undecyl, dodecyl (lauryl), tridecyl, tetradecyl, pentadecyl, or hexadecyl benzene sulfonate; and the higher alkyl toluene, xylene, and phenol sulfonates; alkyl naphthalene sulfonate, ammonium diamyl naphthalene sulfonate, and sodium dinonyl naphthalene sulfonate; sulfated aliphatic alcohols such as sodium lauryl and hexadecyl sulfates, triethanolamine lauryl sulfate, and sodium oleyl sulfate; sulfated alcohol ethers, such as lauryl, tridecyl, or tetradecyl sulfates including 2-4 ethylene oxide moieties; sulfated and sulfonated fatty oils, acids or esters such as the sodium salts of sulfonated castor oil and sulfated red oil; sulfated hydroxyamides such as sulfated hydroxyethyl lauramide; sodium salt of lauryl sulfoacetate; sodium salt of dioctyl sulfosuccinate; and the sodium salt of oleyl methyl tauride.
Other anionic surface active agents which may be employed in the practice of this invention include olefin sulfonates, typically containing 8-25 carbon atoms.
Also included within the ambit of the invention are the sulfuric acid esters of polyhydric alcohols incompletely esterified with higher fatty acids, e.g., coconut oil monoglyceride monosulfate, tallow diglyceride monosulfate; and the hydroxy sulfonated higher fatty acid esters such as the higher fatty acid esters of low molecular weight alkylol sulfonic acids, e.g., oleic acid ester of isethionic acid.
Nonionic surface active agents are those surface active or detergent compounds which contain an organic hydrophobic group and a hydrophilic group which is a reaction product of a solubilizing group such as carboxylate, hydroxyl, amido or amino with ethylene oxide or with the polyhydration product thereof, a polyethylene glycol.
As examples of nonionic surface active agents there may be noted the condensation products of alkyl phenols with ethylene oxide, e.g., the reaction product of isooctyl phenol with about 6 to 30 ethylene oxide units; condensate products of alkyl thiophenols with 10 to ethylene oxide units; condensation products of higher fatty alcohols such as tridecyl alcohol with ethylene oxide; ethylene oxide addends of monoesters of hexahydric alcohols and inner ethers thereof such as sorbitan monolaurate, sorbitol monoleate and mannitan monopalmitate and the condensation products of propylene glycol with ethylene oxide.
Cationic surface active agents may also be employed. Such agents are those surface active detergent compounds Which contain an organic hydrophobic group and a cationic solubilizing group. Typical cationic solubilizing groups are amine and quaternary groups.
As examples of suitable synthetic cationic detergents there may be noted the diamines such as those of the type RNHC H NH wherein R is an alkyl group of about 12 to 22 carbon atoms, such as N-aminoethyl stearyl amine and N-laminoethyl myristyl amine; amide-linked amines such as those of the type RCONHC H NH wherein R is an alkyl group of about 12 to 18 carbon atoms, such as N-amino ethyl-stearyl amide and N-amino ethyl myristyl amide; quaternary ammonium compounds wherein typically one of the groups linked to the nitrogen atom is an alkyl group of about 12 to 18 carbon atoms and three of the groups linked to the nitrogen atom are alkyl groups which contain 1 to 3 carbon atoms, including such 1 to 3 carbon alkyl groups bearing inert substituents, such as phenyl groups, and there is present an anion such as halogen, acetate and methosulfate. Typical quaternary ammonium detergents are ethyl-dimethyl-stearyl ammonium chloride, benzyl-dimethyl-stearyl ammonium chloride, trimethyl-stearyl ammonium chloride, trimethyl-cetyl ammonium bromide, methyl-ethyl-dilauryl ammonium chloride, dimethyl-propyl-myristyl ammonium chloride, and the corresponding methosulfates and acetates.
The surface active compounds which are used in the most preferred aspects of this invention are those having anionic or nonionic properties. The most highly preferred water soluble anionic detergent compounds are the ammonium and substituted ammonium (such as mono-, diand triethanolamine), alkali metal (such as sodium and potassium) and alkaline earth metal (such as calcium and magnesium) salts of the higher alkyl benzene sulfonates, the higher alkyl sulfates, and the higher fatty acid monoglyceride sulfates. The particular salt will be suitably selected depending upon the particular formulation and the proportions therein.
The surface active agent is typically present in amount of about 5-95% by weight of the detergent composition, preferably 10-25% by weight.
The enzyme may be present in powdered form admixed into the detergent formulation.
In addition to the materials described above, the detergent composition of the invention may include a builder for the detergent. The builder may be any of the watersoluble inorganic builder salts commonly known in the art, or it may be a water-soluble organic sequestering agent such as sodium nitrilotriacetate, or mixtures thereof.
The water-soluble inorganic builder salts may be suitable alkali metal, alkaline earth metal, or heavy metal salt or combinations thereof. Ammonium or an ethanolammonium salt in a suitable amount may be added also, but generally the sodium and potassium salts are preferred. Examples are the water-soluble sodium and potas sium phosphates, silicates, carbonates, bicarbonates, borates, sulfates and chlorides. Particularly preferred builder salts are the alkaline builder salts such as polyphosphates, silicates and borates.
In the water-soluble inorganic builder salt mixtures used in the detergent compositions, it is often preferred to have present a mixture of sodium tripolyphosphate and sodium or potassium bicarbonate, such as a combination or mixture of salts wherein the bicarbonate to tripolyphosphate ratio is selected from the range of about 1:1 to about 3:1.
Both Phase I and Phase II sodium tripolyphosphate and mixtures thereof may be successfully used in the compositions. The usual commercial tripolyphosphate consists mainly of the Phase II material. The commercial tripolyphosphate material is usually essentially tripolyphosphate, e.g., 87-95%, with small amounts, e.g., 1-13%, of other phosphates, e.g. pyrophosphate and orthophosphate. Sodium tripolyphosphate in its hydrated form may be used also. Trisodium orthophosphate may be used in the amounts indicated.
The sodium or potassium bicarbonate is an effective buffer. The bicarbonate may be incorporated directly as anhydrous bicarbonate or in the form of sesquicarbonate, a hydrate containing both bicarbonate and carbonate.
Other suitable builder salts which may be present include the water-soluble sodium and potassium silicates, carbonates, borates, chlorides and sulfates.
Generally, when present the builder salt is employed in amount in the range of about 20-90%, preferably at least 25% (e.g. 35 to 80%) of the detergent composition.
The composition may also contain polymeric additives such as sodium carboxymethylcellulose or polyvinyl alcohol (e.g. in amount of about 0.1- or other polymeric additives to inhibit redeposition of soil. Minor amounts of optical brighteners may be present, as in proportions in the range of about 0.01 to 0.15%; examples of such brighteners are the stilbene brighteners such as sodium-2- sulfo-4-(2-naphto-1,2 triazole) stilbene; disodium 4,4- bis(4-anilino-6-morpholino-s-triazin-2-yl-amino) stilbene disulfonate or disodium 4,4-bis(4,6-dianilino-s-triazin-2- yl-amino) stilbenedisul-fonate; and the oxazole brighteners, having for example a l-phenyl-Z-benzoxazole ethylene structure. Perfumes, coloring agents and preservatives may also be included.
The enzyme and triple salt may be added in powdered form to the detergent composition and mixed therewith, as by dry blending. To improve the stability of the compositions, one or more of these ingredients may be protected from the atmosphere or from contact with the others. It is within the broader scope of the invention to supply separate packets (e.g. in moisture proof wrappings) of these ingredients for addition to the wash water.
The compositions of this invention may be used for washing for short periods, e.g. 5 to 45 minutes, in cool water, e.g. at 20-40 C., or in warm or hot water, e.g. at 50, 60 or 70 C., or even at or near the boil. They may also, if desired, be used for long period soaking at room temperature or in hot water, for example, for several hours or overnight.
The following examples are given to illustrate further this invention. In these examples, as in the rest of the application, all proportions are by weight unless otherwise indicated.
EXAMPLE 1 A detergent composition having the following formula is prepared.
Component: Parts, percent Sodium dodecyl benzene sulfonate 28 Pentasodium tripolyphosphate 30 Sodium silicate (SiO /Na O=2/1) 6 Sodium carboxymethyl cellulose 0.8 Tetraanilino stilbene brightener 0.2 Perfume 0.2
Sodium sulfate and moisture, balance.
0.7% subtilisin enzyme (Alcalase) having a proteolytic activity of 1.5 Anson Units per gram and various amounts of active oxygen compounds are added to this detergent to provide active oxygen in amounts indicated in the table below. The active oxygen compounds employed are the monopersulfate triple salt Oxone active oxygen compound (ARd) are indicated in the table below:
TABLE P.p.m. of
active Active oxygen oxygen Active oxygen compound in bath A Rd compound Sodium perborate tetrahydrate 5 46 2 None 0 41 Potassium dipersulfate 1 41 0 D0 2 41. 5 0. 5 Do 5 42. 5 1. 5
It is apparent from the data set forth in the table above that the composition of the invention containing proteolytic enzyme and monopersulfate triple salt is superior in removing blood stains to compositions containing the same enzyme and sodium perborate tetrahydrate or dipersulfate salt.
The subtilisin enzyme Alcalase used in the foregoing examples is characterized as having its maximum proteolytic activity at a pH of 8-9. This activity as measured on the commercial enzyme available from Novo Industri A/S, Copenhagen, Denmark, is about 1.5 Anson units per gram of enzyme. The commercial enzyme is a raw extract of Bacillus subtilis culture.
EXAMPLE 2 Compositions containing Alcalase and Oxone as in Example 1 which are added to detergent having the formulation indicated below also produce superior increases in cleaning capability when stained fabrics are washed with such detergents for one-half hour at 50 C. in a solution containing 0.5% of the detergent.
Sodium sulfate and moisture, balance.
It will be apparent to one skilled in the art that various modifications of the foregoing examples may be made thereto.
I claim:
1. The process of cleaning proteinic blood stains which comprises washing or soaking proteinic blood stained material in an aqueous bath containing a biological cleaning composition consisting essentially of a proteolytic enzyme effective at a pH range of 4-12 in amount corresponding to about 1-40 p.p.m. based on a proteolytic activity of about 1.5 Anson units per gram when said composition is dissolved in water and an alkali metal monopersulfate triple salt in amount to provide about 150 p.p.m. of active oxygen when said composition is dissolved in water.
2. The process as claimed in claim 1 wherein said composition also includes about 5-95% by weight of a synthetic surface-active agent and about 20-80% by weight of a water-soluble detergent builder salt.
3. The process as claimed in claim 1 wherein said proteolytic enzyme is a subtilisin enzyme.
7 8 4. The process as claimed in claim 1 wherein said 3,337,466 8/1967 Puetzer et al 232-99 triple salt is [2KHSO -KHSO -K SO 3,458,446 7/1969 Diaz 252-99 3,556,771 1/1971 Stalter 8-111 References Cited 3,553,139 1/1971 McCarty 252-95 U S CL X R 3,519,379 7/1970 Blomeyer et a1. 252-99 X 3,130,165 4/1964 Brocklehurst 25249 8411 25249 186
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US26626172A | 1972-06-26 | 1972-06-26 |
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US3732170A true US3732170A (en) | 1973-05-08 |
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US00266261A Expired - Lifetime US3732170A (en) | 1972-06-26 | 1972-06-26 | Bio-soaking performances |
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Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3988254A (en) * | 1973-06-14 | 1976-10-26 | Fuji Photo Film Co., Ltd. | De-smutting agent |
EP0148114A1 (en) * | 1983-11-03 | 1985-07-10 | Battelle Memorial Institute | Process for preparing decolorized blood proteins |
US4678597A (en) * | 1986-03-17 | 1987-07-07 | Am International, Inc. | Chemical cleaning solution and method |
US4804491A (en) * | 1986-11-03 | 1989-02-14 | The Clorox Company | Aqueous based acidic hard surface cleaner |
US4895669A (en) * | 1986-11-03 | 1990-01-23 | The Clorox Company | Aqueous based acidic hard surface cleaner |
US5183473A (en) * | 1991-04-26 | 1993-02-02 | Monsanto Company | Enzyme activated peroxydisulfate bleach composition |
WO1993018129A1 (en) * | 1992-03-12 | 1993-09-16 | The Procter & Gamble Company | Low-dosage automatic dishwashing detergent with monopersulfate and enzymes |
US5399283A (en) * | 1986-01-15 | 1995-03-21 | Amgen Inc. | Thermally stable and pH stable subtilisin analogs and method for production thereof |
US5559089A (en) * | 1992-03-12 | 1996-09-24 | The Procter & Gamble Company | Low-dosage automatic dishwashing detergent with monopersulfate and enzymes |
US5599781A (en) * | 1995-07-27 | 1997-02-04 | Haeggberg; Donna J. | Automatic dishwashing detergent having bleach system comprising monopersulfate, cationic bleach activator and perborate or percarbonate |
-
1972
- 1972-06-26 US US00266261A patent/US3732170A/en not_active Expired - Lifetime
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3988254A (en) * | 1973-06-14 | 1976-10-26 | Fuji Photo Film Co., Ltd. | De-smutting agent |
EP0148114A1 (en) * | 1983-11-03 | 1985-07-10 | Battelle Memorial Institute | Process for preparing decolorized blood proteins |
US5399283A (en) * | 1986-01-15 | 1995-03-21 | Amgen Inc. | Thermally stable and pH stable subtilisin analogs and method for production thereof |
US4678597A (en) * | 1986-03-17 | 1987-07-07 | Am International, Inc. | Chemical cleaning solution and method |
US4804491A (en) * | 1986-11-03 | 1989-02-14 | The Clorox Company | Aqueous based acidic hard surface cleaner |
US4895669A (en) * | 1986-11-03 | 1990-01-23 | The Clorox Company | Aqueous based acidic hard surface cleaner |
US5183473A (en) * | 1991-04-26 | 1993-02-02 | Monsanto Company | Enzyme activated peroxydisulfate bleach composition |
WO1993018129A1 (en) * | 1992-03-12 | 1993-09-16 | The Procter & Gamble Company | Low-dosage automatic dishwashing detergent with monopersulfate and enzymes |
US5559089A (en) * | 1992-03-12 | 1996-09-24 | The Procter & Gamble Company | Low-dosage automatic dishwashing detergent with monopersulfate and enzymes |
US5599781A (en) * | 1995-07-27 | 1997-02-04 | Haeggberg; Donna J. | Automatic dishwashing detergent having bleach system comprising monopersulfate, cationic bleach activator and perborate or percarbonate |
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