US3700089A - Analyzer apparatus - Google Patents

Analyzer apparatus Download PDF

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Publication number
US3700089A
US3700089A US145152A US3700089DA US3700089A US 3700089 A US3700089 A US 3700089A US 145152 A US145152 A US 145152A US 3700089D A US3700089D A US 3700089DA US 3700089 A US3700089 A US 3700089A
Authority
US
United States
Prior art keywords
bands
receptacles
apertures
transport
band
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US145152A
Other languages
English (en)
Inventor
Ingomar Halbartschlager
Alfred Heim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Hoffmann La Roche Inc
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of US3700089A publication Critical patent/US3700089A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G15/00—Conveyors having endless load-conveying surfaces, i.e. belts and like continuous members, to which tractive effort is transmitted by means other than endless driving elements of similar configuration
    • B65G15/22—Conveyors having endless load-conveying surfaces, i.e. belts and like continuous members, to which tractive effort is transmitted by means other than endless driving elements of similar configuration comprising a series of co-operating units
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G2201/00—Indexing codes relating to handling devices, e.g. conveyors, characterised by the type of product or load being conveyed or handled
    • B65G2201/02—Articles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00—Special receptacle or package
    • Y10S206/82—Separable, striplike plural articles

Definitions

  • ABSTRACT An analytical apparatus for use in transporting in an automatic analyzer, a plurality of individual analytical samples having several transport bands each band including one or more receptacles for containing samples alternating with one or more apertures, the bands being offset with respect to one another to display at a position on one band a receptacle vwhere all other bands have apertures thereby enabling the bands to be married to each other to form a continuous series of receptacles for passage by a sample transfer station and further enabling the bands to be individually passed through separate analyzing stations.
  • PATENTEIJom 24 I972 v I sum 3 or 3 r-- I ISY F mcus CHAMBER i k REAGENT MIXING STATION 45 SAMPLE PUMPS PUMPS T "l I/ DRIVE 49 I MOTOR I I I 4 FIG. 5 J r r v mcua g--- CHAMBER L j ANALYZER APPARATUS BACKGROUND OF THE INVENTION
  • This invention is concerned with the automatic analyses of specimens and more particularly to a technique for transporting individual receptacles or containers in automatic analyzer for individual analyses.
  • Such systems normally entail a strict order of succession of the individual samples, which, of course, dictates a loss in theflexibility of a system.
  • This disadvantage essentially arises from the fact that for one passage of a series of samples only a single incubation time and temperature or a single specific sequence of incubation times and temperatures (in the case of several incubation chambers arranged in series) can be chosen.
  • a separate sample passage has to be provided for each analysis requiring another incubation time or temperature. For example, in a case in which perhaps analyses are carried out for each sample, for the first incubation chamber alone there may amount to five different time-temperature combinations which correspondingly make five passages necessary.
  • a further disadvantage of this system consists in that the result of urgent individual analyses (which can be interpolated between two passages) is only available after prolonged waiting time, however, it is often desired (e.g. in emergencies) to obtain such results rapidly.
  • the object of the present invention is to provide a conveying means which overcomes the disadvantages of the aforedescribed known conveying means.
  • a conveying means which comprises several synchronously running transport bands, parallel at least in places, in that on each of these transport bands one or more receptacles alternate with one or more apertures, in that in each instance at a position at which one transport band displays a receptable all other transport bands have apertures, and in that the transport bands either can be conducted flatly on top of or behind each other, the receptacles of all transport hands together forming a continuous series, or can be conducted separately at a distance from each other, for
  • a further object consists of undertaking several incubations by repeated passage of a transport hand through an incubation chamber and undertaking measurements at any given time between the individual incubations.
  • FIG. 1 is a perspective view of a part of a conveying means in accordance with the invention, composed of three transport bands, for the transport of samples through an automatic analyzer.
  • FIGS. 2-4 represent various combination possibilities of transport and receptacle and aperture arrangements.
  • FIGS. 5, 6 is schematic flow diagram of an analysis run using the conveying means in accordance with the invention.
  • Each transport band displays receptacles or containers arranged at regular intervals.
  • the receptacles of the first transport band 11 which can be seen in FIG. 1 are denoted by 12, 13, 14, those of the second transportband 21 by 22, 23, 24 and those of third transport band 31 by 32, 33, 34.
  • the empty spaces Hand 16 accordingly lie between the receptacles 12 and 13 of the transport band 11.
  • Such an empty space e.g. '15
  • a receptacle of a transport band lying behind can readily fit in.
  • the receptacle 22 of transport band 21 fits into the aperture 15 and the receptacle 32 of transport band 31 similarly fits into the aperture 26 of the second band 21 and the aperture 16 of the first band 11, and so on.
  • the receptacles After being temporarily combined or married at point 10, the receptacles project through the apertures on the front side of the group of combined bands between the points 10 and 20 to take on the appearance and operational characteristics of a single transport band with a continuous series of receptacles. At point 20 the bands are separated into individual transport bands which can then perhaps be subjected to different procedures.
  • the construction of the individual bands by way of the examples of the transport band 11, may be comprised of two strip-shaped layers 17, 18 each consisting of a transparent, flexible and heat-weldable foil of synthetic material.
  • bulges are pressed in one of the two foil strips (e.g. 18) at fixed intervals determined by the receptacle disposition already described, while the second strip 17 is used in the unaltered flat state.
  • These two strips are so welded with each other than the bulges form sealed pocket-shape receptacles.
  • windows with suitable dimensions are stamped at intervals which are likewise determined by the hereinbefore described manner of formation of groups of bands.
  • n analyses are carried out with one sample.
  • the group of bands must therefore have n individual transport bands, each of which provides a receptacle for an amount of each sample.
  • n individual transport bands each of which provides a receptacle for an amount of each sample.
  • FIG. 2 shows that in the first transport band in each case a sample receptacle 41 alternates with n-l empty spaces 42, in the second transport band, displaced by one space, a sample receptacle 43 alternates with n-l empty spaces 44, and so on.
  • 2 n analyses are to be carried out with each sample, whereby pairs of which require the same incubation conditions.
  • each of n transport bands has two chambers for each sample, alternating with 2(n-l apertures.
  • the passage of a group of a transport bands through the various stations of a conventional automatic analyzer is shown in FIG. 5.
  • the individual transport bands are produced at the input of the system or are unwound from storage reels and driven by a suitable drive motor so to be brought together at a point'45 so that the chambers form a continuous series (corresponds to point 10 in FIG. 1).
  • the transport band group thus formed passes through a series of filling stations in which predetermined amounts of samples and reagents are filled into the receptacles.
  • the receptacles subsequently pass a mixing station in which the samples are mixed with the reagents, for example by application of acoustic vibrations.
  • the mixing station is the last station which is passed through by all transport bands together.
  • the trans port bands are separated at point 49 and individually conducted to the incubation chambers 51, in which case the incubation times and/or temperatures can be different. After the incubation, the reactions effected have to be measured. For this purpose, depending on the requirements of the measurement either all or a part of the transport bands can again be brought together and conducted through a measuring apparatus or each band can be individually assigned to a separate measuring apparatus. After the measurement, the bands are usually immediately destroyed.
  • the samples are repeatedly incubated, usually under the same conditions, and the reaction is measured between the individual incubations.
  • the transport bands in accordance with the invention are suitable for such enzymatic measurements.
  • a transport band 54 which contains the samples and reagents intended for the enzymatic measurements, passes during the time t, through the incubation chamber 55 which is specially constructed for several incubation passages. After the first incubation for t, a first measurement is effected in the measuring apparatus 56 (e.g. a photometer).
  • An analytical apparatus for transporting in an automatic analyzer, a plurality of analytical samples where each sample is adapted to be contained in a spatially separated individual receptacle comprising,
  • each band including one or more of such receptacles alternating with one or more apertures each having an opening configuration adapted for receiving a receptacle
  • said bands when offset with respect to one another, displaying on one band a receptacle at a position where all other bands have apertures enabling said bands to be married on top of or behind each other whereby the receptacles of bands lying behind project through the apertures of the bands lying ahead to form a continuous series of receptacles for sample receiving purposes.
  • each transport band is comprised of substantially flat foil strips provided with pocket-shaped receptacles.
  • each transport band comprises two strip-shaped foils of synthetic material joined flatly with each other, between which pocket-shaped receptacles are formed by the bulging of one foil strip.
  • each of said bands including one or more of such receptacles alternating with one or more apertures having an opening configuration adapted for receiving a receptacle;
  • said bands when offset with respect to one another, displaying on one band a receptacle at a position where all other bands have apertures, enabling said bands to be married to each other whereby the receptacles of bands lying behind project through the apertures of the bands lying ahead to form a continuous series of receptacles;
  • conveying means adapted for driving said bands in synchronism in such married relationship past a sample transfer station.
  • said conveying means also includes means for individually driving said bands by separate sample analyzing stations.
  • each transport band is comprised of substantially flat foil strips provided with pocket-shaped receptacles.
  • each transport band comprises two strip-shaped foils of synthetic material welded flatly with each other, between which receptacles are formed by the bulging of one foil strip.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US145152A 1970-06-01 1971-05-20 Analyzer apparatus Expired - Lifetime US3700089A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH816170A CH524524A (de) 1970-06-01 1970-06-01 Förderer

Publications (1)

Publication Number Publication Date
US3700089A true US3700089A (en) 1972-10-24

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Application Number Title Priority Date Filing Date
US145152A Expired - Lifetime US3700089A (en) 1970-06-01 1971-05-20 Analyzer apparatus

Country Status (6)

Country Link
US (1) US3700089A (fr)
BE (1) BE767802A (fr)
CH (1) CH524524A (fr)
DE (1) DE2125966A1 (fr)
FR (1) FR2093958B3 (fr)
NL (1) NL7105786A (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328184A (en) * 1979-11-30 1982-05-04 Fuji Photo Film Co., Ltd. Test slide strip
US5234105A (en) * 1990-02-22 1993-08-10 Matsushita Electric Industrial Co., Ltd. Packages for circuit boards for preventing oxidation thereof
US5261535A (en) * 1992-05-29 1993-11-16 Eastman Kodak Company Flexible photographic film package
US5736100A (en) * 1994-09-20 1998-04-07 Hitachi, Ltd. Chemical analyzer non-invasive stirrer
US20020102186A1 (en) * 2001-01-31 2002-08-01 Mcentee John F. Automation-optimized microarray package
US20030170148A1 (en) * 2001-01-31 2003-09-11 Mcentee John F. Reaction chamber roll pump
US20050023730A1 (en) * 2001-12-04 2005-02-03 Preh-Werke Gmbh & Co. Kg Pouch-shaped or pot-shaped parts and use of the parts for accommodating samples or the like
FR2903668A1 (fr) * 2006-07-11 2008-01-18 Rech S Et De Conceptions Arc S Machine de ficelage pour la mise en place de liens croises autour de produits, notamment de produits carnes
US8069636B1 (en) * 2008-03-05 2011-12-06 Charles Gutentag Method and apparatus to facilitate retention and removal of components placed on adhesive backed carrier tape for automated handling
AU2017218430B2 (en) * 2016-02-08 2022-07-07 Becton, Dickinson And Company Prepared plated media product

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3010670B2 (ja) * 1990-02-22 2000-02-21 松下電器産業株式会社 配線回路基板包装体、および、配線回路基板包装体からの配線回路基板取出し方法と装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3465874A (en) * 1967-06-12 1969-09-09 Frances Hugle Carrier for semiconductor devices
US3587524A (en) * 1968-12-26 1971-06-28 Western Electric Co Coating apparatus including conveyer-mask

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3465874A (en) * 1967-06-12 1969-09-09 Frances Hugle Carrier for semiconductor devices
US3587524A (en) * 1968-12-26 1971-06-28 Western Electric Co Coating apparatus including conveyer-mask

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328184A (en) * 1979-11-30 1982-05-04 Fuji Photo Film Co., Ltd. Test slide strip
US5234105A (en) * 1990-02-22 1993-08-10 Matsushita Electric Industrial Co., Ltd. Packages for circuit boards for preventing oxidation thereof
US5261535A (en) * 1992-05-29 1993-11-16 Eastman Kodak Company Flexible photographic film package
US5736100A (en) * 1994-09-20 1998-04-07 Hitachi, Ltd. Chemical analyzer non-invasive stirrer
US7112305B2 (en) * 2001-01-31 2006-09-26 Agilent Technologies, Inc. Automation-optimized microarray package
US20020102186A1 (en) * 2001-01-31 2002-08-01 Mcentee John F. Automation-optimized microarray package
US20030170148A1 (en) * 2001-01-31 2003-09-11 Mcentee John F. Reaction chamber roll pump
US20050023730A1 (en) * 2001-12-04 2005-02-03 Preh-Werke Gmbh & Co. Kg Pouch-shaped or pot-shaped parts and use of the parts for accommodating samples or the like
FR2903668A1 (fr) * 2006-07-11 2008-01-18 Rech S Et De Conceptions Arc S Machine de ficelage pour la mise en place de liens croises autour de produits, notamment de produits carnes
WO2008006962A3 (fr) * 2006-07-11 2008-03-06 Rech S Et De Conceptions A R C Machine de ficelage pour la mise en place de liens croisés autour de produits, notamment de produits carnés
US8069636B1 (en) * 2008-03-05 2011-12-06 Charles Gutentag Method and apparatus to facilitate retention and removal of components placed on adhesive backed carrier tape for automated handling
AU2017218430B2 (en) * 2016-02-08 2022-07-07 Becton, Dickinson And Company Prepared plated media product
US11680234B2 (en) 2016-02-08 2023-06-20 Becton, Dickinson And Company Prepared plated media product

Also Published As

Publication number Publication date
NL7105786A (fr) 1971-12-03
CH524524A (de) 1972-06-30
FR2093958A7 (fr) 1972-02-04
FR2093958B3 (fr) 1973-10-19
DE2125966A1 (de) 1971-12-16
BE767802A (fr) 1971-11-29

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