Classifications

• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/0005—Isotope delivery systems
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01D—SEPARATION
  • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01G—WEIGHING
  • G01G23/00—Auxiliary devices for weighing apparatus
  • G01G23/18—Indicating devices, e.g. for remote indication; Recording devices; Scales, e.g. graduated
  • G01G23/20—Indicating weight by mechanical means
  • G01G23/30—Indicating weight by mechanical means with means for illuminating the scale
• • H—ELECTRICITY
  • H01—ELECTRIC ELEMENTS
  • H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
  • H01M6/00—Primary cells; Manufacture thereof
  • H01M6/42—Grouping of primary cells into batteries
• • H—ELECTRICITY
  • H04—ELECTRIC COMMUNICATION TECHNIQUE
  • H04B—TRANSMISSION
  • H04B1/00—Details of transmission systems, not covered by a single one of groups H04B3/00 - H04B13/00; Details of transmission systems not characterised by the medium used for transmission
  • H04B1/06—Receivers
  • H04B1/08—Constructional details, e.g. cabinet
• • G—PHYSICS
  • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
  • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
  • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
  • G21G1/001—Recovery of specific isotopes from irradiated targets
  • G21G2001/0042—Technetium

Definitions

• radioactive isotopes such as lodine Technetium 99", Yttrium, and many others, such as l-131, ST-85, Sr--87" and P-32, have been used in the medical and biological fields as tracer elements for investigative and diagnostic purposes and in some cases as a therapeutic agent.
• Many of these radioactive isotopes are delivered to the user by means of a generator, wherein the radioactive isotope is contained on an ion exchange resin in its parent form.
• the generator thus utilized has become known to the art as a cow and the operation of eluting the daughter isotope from its parent has become known as a milking" process.
• the eluent in this invention is a saline solution which is prepared by methods known to the art.
• the saline solution may be 0.9 percent sodium chloride solution or an isotonic sodium chloride solution.
• the oxidizing agent added to this solution may be oxygen (bubbling it through the solution), an alkali metal hypochlorite (e.g., sodium hypochlorite), an alkali metal permanganate (e.g., potassium permanganate), ferthe radioisotope to be separated or eluted from the generator.
• the method of utilizing the modified eluent of this invention is the same as customarily utilized in eluting generators whether they be of the sterile of non-sterile type.
• Solution E 0.9% Sodium chloride with 0.01% available chlorine H 5.5.
• Solutions C, and E which are isotonic chlorine saline solu- TABLE 1 [Tc yield using various eluting solutions]
• Generator MC Milking 'Ic T0 o Potency eluent MC /25 percent MO Gen. Milking assayed label solution ml. of label content 128 100 B 105 105 N one. 2 100 78 B 72 92 Do. 100 1110..-- 78 61 B 52 85 Do. 4 61 47 D0. 47 37 E 34. 2 92 D0. is 316 200 B 130 65 Do. 2 246 156 B 70 Do. 200 mc 192 122 B 47 39 Do. 4 150 95 Do.
• ric chloride hydrogen peroxide and an alkali metal perhalogenate (e.g., potassium perchloride, sodium perbromide, and so forth).
• alkali metal perhalogenate e.g., potassium perchloride, sodium perbromide, and so forth.
• organic and inorganic oxidizing agents such as peracetic acids, cupric acetate, iodoisobenzene, phenanthrenequinone, and pyridine N-oxide may also be utilized in the practice of this invention.
• the concentration of the oxidizing agent on a v/v basis should be in the range of from about 0.01 percent to 0.1 percent. However, depending upon the oxidizing agent utilized, a concentration in the range of from about 0.001 percent to about 1 percent may be preferable. However, it has been discovered that extremely satisfactory results are obtained when the concentration of the oxidizing agent is in the range on a v/v basis of from about 0.02 percent to about 0.05 percent.
• the initial eluent may be sterilized water, sterilized saline solution, an acid eluent or basic eluent depending upon the ion exchange resin utilized in the cow and From the above Table it is established that the yield of Technetium 99" can be significantly increased by utilizing isotonic chlorine water.
• An eluent solution for use in eluting radioactive isotopes from an ion exchange resin consisting essentially of an isotonic saline solution and an oxidizing agent said oxidizing agent being present in a concentration of from about 0.001 percent to about 1.0 percent on a volume/volume ratio.
• oxidizing agent is selected from the group consisting of oxygen, an alkali metal hypochlorite, an alkali metal permanganate, an alkali metal perhalogenate, ferric chloride, hydrogen peroxide, peracetic acids, cupric acetate, iodoisobenzene, phenanthrene-quinone and pyridine N-oxide.

Landscapes

• Chemical & Material Sciences (AREA)
• Physics & Mathematics (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Epidemiology (AREA)
• Computer Networks & Wireless Communication (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Analytical Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Optics & Photonics (AREA)
• Life Sciences & Earth Sciences (AREA)
• Signal Processing (AREA)
• General Physics & Mathematics (AREA)
• Medicinal Chemistry (AREA)
• General Engineering & Computer Science (AREA)
• High Energy & Nuclear Physics (AREA)
• Manufacturing & Machinery (AREA)
• Electrochemistry (AREA)
• Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
• Treatment Of Liquids With Adsorbents In General (AREA)
• Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Applications Claiming Priority (1)

Publications (1)

Family

ID=24983595

Family Applications (1)

Country Status (10)

Cited By (6)

Families Citing this family (6)

• 1968
  • 1968-07-03 US US742128A patent/US3664964A/en not_active Expired - Lifetime
• 1969
  • 1969-06-09 DE DE19691929067 patent/DE1929067A1/de active Pending
  • 1969-06-09 CA CA053807A patent/CA929685A/en not_active Expired
  • 1969-07-01 ES ES369006A patent/ES369006A1/es not_active Expired
  • 1969-07-03 BE BE735608D patent/BE735608A/xx unknown
  • 1969-07-03 NL NL6910212A patent/NL6910212A/xx unknown
  • 1969-07-03 GB GB29368/69A patent/GB1280537A/en not_active Expired
  • 1969-07-03 CH CH1018469A patent/CH501425A/fr not_active IP Right Cessation
  • 1969-07-03 FR FR6922586A patent/FR2012258A1/fr not_active Withdrawn
  • 1969-07-03 CS CS4744A patent/CS161858B2/cs unknown

Also Published As

Similar Documents