US3640388A - Dialyzing liquid-collecting container - Google Patents

Dialyzing liquid-collecting container Download PDF

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Publication number
US3640388A
US3640388A US65540A US3640388DA US3640388A US 3640388 A US3640388 A US 3640388A US 65540 A US65540 A US 65540A US 3640388D A US3640388D A US 3640388DA US 3640388 A US3640388 A US 3640388A
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United States
Prior art keywords
compartment
chamber
container
passage
liquid
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Expired - Lifetime
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US65540A
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English (en)
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Andres Ferrari
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Damon Corp
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Damon Corp
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150343—Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150763—Details with identification means
    • A61B5/150786—Optical identification systems, e.g. bar codes, colour codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150946—Means for varying, regulating, indicating or limiting the speed or time of blood collection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/28—Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A61J1/12—Bag-type containers with means for holding samples of contents

Definitions

  • a liquid container, pumpable to aspirate liquid into it via an inlet passage, has a dialyzing membrane forming first and second compartments within the container on either side of the membrane.
  • the inlet passage feeds into only one of the two compartments and that one compartment, at least, includes pumpable walls of the container.
  • the chemical analysis of dialysis fractions i.e., of the crystalline and/or amorphous constituents of liquid samples, such as of blood, has conventionally required that the dialysis be performed with equipment separate from the container in which the sample is collected or stored. Further, the samples typically are dialyzed only at the time of the chemical analysis and with equipment separate from that used for the analysis.
  • prior dialyzing containers such as the one disclosed in US. Pat. No. 3,485,751 of Hermann and Spadoni, are not capable of aspirating the liquid into a compartment out of which the crystalline constituents are to diffuse for collection in a further compartment.
  • an object of this invention is to provide portable container equipment for the collection of liquid samples, such as of animal body fluid, and for the removal of crystalline portions thereof into a separate compartment commencing immediately upon collection of the sample.
  • Another object of the invention is to provide container equipment of the above character that aspiratively collects the liquid sample.
  • a pumpable liquid container normally closed except for an inlet tubing or other passage is provided with a dialyzing membrane that forms two compartments on either side thereof within the container.
  • the inlet to the container feeds into only one of these two compartments.
  • the other walls of this one compartment include, at least in part, the pumpable walls of the container.
  • the container walls are readily collapsed and released to aspirate liquid into the one compartment, and crystalline constituents of the collected liquid diffuse into the other compartment.
  • crystalline constituents of the collected liquid diffuse into the other compartment.
  • the container is readily constructed so that the liquid portions in each compartment can be delivered directly from the container to analysis equipment.
  • FIG. 1 is a pictorial view, partly broken away, of a container embodying the invention disposed for collecting a blood sample from a dermal puncture of a finger;
  • FIG. 2 is a cross-sectional view of the container of FIG. 1 taken along line 22 thereof.
  • a container 10 constructed in accordance with the aforementioned application Ser. No. 884,924 and further embodying the invention has a graduated passage 12 feeding from an inputopening 14 into a donor compartment 16 of a collapsible chamber 18.
  • a dialyzing membrane 20 forms the donor compartment 16 within the chamber alongside a recipient compartment 22 on the other side of the membrane. The two compartments are sealed from each other except for the porosity of the membrane 20.
  • a liquid reagent 28 for preserving and/or diluting the sample can be placed in the chamber 18 prior to the collection of the sample.
  • a record panel 30 bearing identification of the sample being collected and other pertinent information can be provided on the container to extend along the side of the chamber 18 and serves, together with the coiled collection passage 12 and the chamber 18, as a handle for the secure holding of the container during the sample collection process.
  • the opposed chamber walls 24 and 26 are shown in FIG. 1 slightly collapsed into the chamber, as the medical technician or other operator normally would do during the sample-collecting process simply by squeezing the walls together prior to placing the input opening 14 into the liquid being collected.
  • the resiliency of the chamber walls 2446 restores the chamber to an uncollapsed condition and thereby draws the liquid into the passage 12 under positive pressure conditions.
  • the operator controls the expansion of the chamber walls until he has collected the desired volume of sample in the passage 12, at which point he simply removes the input opening 14 from the liquid source and fully releases the chamber walls. This allows them to resume their normal uncollapsed condition shown in FIG. 2 and thereby to aspirate the collected sample from the passage 12 into the donor compartment 16 of the chamber.
  • the passage 12 can be sealed closed, either at the opening 14 or along the length thereof, in a conventional manner.
  • the dialysis is complete. During this time the filled container 10 can simply be stored or can be transported to a laboratory for the analysis or other processing of the sample.
  • each compartment can be withdrawn by way of a needle puncturing the outer wall of 24 or 26 of the compartment of interest.
  • the container can be cut open, as along the dashed line 32, or otherwise, to expose the compartment contents.
  • the chamber 18 can be provided with one or more initially sealed outlet tubes leading from each compartment.
  • the chamber 18 is thus seen to be a pouchlike vessel with opposed resiliently collapsible sidewalls 24 and 26.
  • the passage 12 feeds into the container adjacent a top end thereof and the principal volume of the chamber is below this entry point when the container is in the normal upright orientation. This is normally the orientation in which the container is held IOIOZZ 0286 during the collection of the sample, and is shown in FIG. 1 for the illustrated container, which has the passage entry 14 at the container bottom. Further, the illustrated chamber is fluidtight except for the entry of the passage l2 into it.
  • the chamber volume is tailored to the maximum volume of sample which is to be collected.
  • the chamber should have a donor compartment with a volume, in excess of the volume of reagent 28 therein, that is at least two and preferably three or more times larger than the volume of sample to be collected.
  • the opposed chamber walls 24, 26 can be depressed inward to reduce the volume of the donor compartment 16 by at least twice the volume of the graduated passage 12. Upon being released, the container walls restore automatically to their normal concave shape, FIG. 2, with sufficient resilient force to aspirate the sample liquid into the passage 12 and then into the donor compartment 16.
  • the illustrated container is constructed as a laminate of two casing panels 34 and 36.
  • Panel 34 which includes the chamber wall 24, is recessed with a channel that forms walls of the passage 12.
  • the other panel 36 is basically identical to the panel 24 except that it has no channel. Instead panel 36 has a flat surface opposite the passage-forming channel of panel 34 and which closes the channel to form the passage 12.
  • the casing panel 36 includes the chamber wall 26.
  • the record panel 30 of the illustrated container is provided entirely by the casing panel 36.
  • the two casing panels 34 and 36 are bonded together as shown, with the dialyzing membrane 20 sealed between their mating faces continuously along the juncture of the chamber wall 26 with the adjoining portions of the casing panel 36.
  • the membrane 20 thus divides the bulbous space between the walls 24 and 26 into the two compartments 16 and 22, and the passage 12 feeds only into the donor compartment 16.
  • the casing panels 34 and 36 can, by way of example, be made of polyethylene.
  • the chamber wall portions thereof can be thinner than the other portions thereof as illustrated, to provide the desired flexible resiliency for these walls.
  • the casing panel 36 can have a different thickness along the record panel 30 than along the nonchamber wall portions; it is illustrated as forming a thinner record panel. in the illustrated container 10, the two casings together have sufficient overall rigidity so that the container normally maintains the overall upright shape as shown.
  • dialyzing membrane can be made of conventional material for semipermeable membranes such as regenerated cellulose, nitrocellulose or radiation-drilled plastic.
  • a typical membrane 20 has a thickness of 0.0005 to 0.0009 inch and has pores between 40 and 60 angstroms in diameter.
  • the foregoing dimensions for the semipermeable membrane and illustrated construction for the container are for collecting blood and separating the protein-free filtrate from the proteinatious constituents.
  • the invention can be used to provide other separations of micromolecular constituents from a mixture with larger, macromolecular con stitucnts. in each instance, of course, the semipermeable membrane 20 is selected with pores of the diameter corresponding to the desired separation of molecule sizes.
  • the invention provides a pumpable liquidaspirating container having two compartments therein separated by a dialyzing membrane such that the liquid is aspirated into one compartment only and that crystalline constituents thereof diffuse into the other compartment.
  • the container is thus well adapted for the initial collection of a liquid sample, for storing the sample as long as needed and throughout whatever transportation is involved. After the storage time, a portion of the crystalline constituents of the sample are available to be withdrawn from the container free from the amorphous constituents.
  • the wall 26 will collapse only slightly, if at all.
  • the opposed wall 24 of the donor compartment will collapse as desired. It should hence be understood that only the donor compartment 16 needs to be pumpable for aspirating a sample.
  • Liquid container apparatus comprising A. liquid-impervious wall means forming a chamber with at least a collapsible and resiliently restoring externally accessible wall portion,
  • inlet tubing means feeding into only said first of said first and second compartments, and said first compartment being closed except for said inlet tubing means and the porosity of said membrane.
  • Container apparatus as defined in claim 1 in which A. said wall means forms said chamber with at least two opposed collapsible and resiliently restoring externally accessible wall portions, and
  • said dialyzing membrane is disposed in said chamber between said two opposed wall portions such that each wall portion forms a portion of a different one of said first and second compartments.
  • Container apparatus as defined in claim 1 in which said chamber extends along a first axis and said inlet tubing means feeds into said first compartment adjacent an extreme end thereof along said first axis.
  • a container for the collection, storage and dialysis of a liquid comprising A. a tubelike collection passage having first and second ends and a first storage volume therein between said ends,
  • a second chamber compartment contiguous with said first compartment and having said semipermeable dialysis membrane forming also a portion thereof for the passage of dialyzate between said first and second compartments through said membrane, and forming with said first compartment an enclosure normally fluidtight except for the entry of said passage into said first compartment.
  • a container as defined in claim 5 further comprising a volume-indicating scale arranged along said passage for indicating the volume of liquid in said passage measuring from said second end thereof.
  • a container for the collection, storage and dialysis of communication from the interior of said first compartliquid said container comprising ment through said passage to the said inlet end thereof,
  • B. means forming a tubular passage on said casing with an 5 compartment and collapsible to diminish the volume of openly accessible inlet end, an outlet end, and a storage Said first compartmffilt and resiliently resuming 3 l h therebetween, mal uncollapsed position.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
US65540A 1970-08-20 1970-08-20 Dialyzing liquid-collecting container Expired - Lifetime US3640388A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6554070A 1970-08-20 1970-08-20
US6976770A 1970-09-04 1970-09-04

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US3640388A true US3640388A (en) 1972-02-08

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US65540A Expired - Lifetime US3640388A (en) 1970-08-20 1970-08-20 Dialyzing liquid-collecting container
US69767A Expired - Lifetime US3640393A (en) 1970-08-20 1970-09-04 Liquid container having pressure-protected dialyzing membrane

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US69767A Expired - Lifetime US3640393A (en) 1970-08-20 1970-09-04 Liquid container having pressure-protected dialyzing membrane

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JP (1) JPS4923429B1 (da)
AU (1) AU2337570A (da)
BE (1) BE763805A (da)
BR (1) BR7102250D0 (da)
CA (2) CA933126A (da)
CH (1) CH543084A (da)
DE (1) DE2101423A1 (da)
DK (1) DK124170B (da)
FR (1) FR2101378A5 (da)
GB (1) GB1312498A (da)
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ZA (1) ZA708336B (da)

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US3774762A (en) * 1971-01-20 1973-11-27 E Lichtenstein Analogue fluid flow programming structures
US3817379A (en) * 1972-07-10 1974-06-18 Amicon Corp Disposable liquid concentrating device
US3906935A (en) * 1973-06-29 1975-09-23 Gard Ind Inc Medical fluid drainage and sampling system
US3933439A (en) * 1974-04-29 1976-01-20 Mcdonald Bernard Blood collection device
US3976574A (en) * 1974-11-04 1976-08-24 Cobe Laboratories, Inc. Negative pressure control system
US4134730A (en) * 1977-09-20 1979-01-16 Quame Babington A Spotting systems and methods pertaining thereto
US4637917A (en) * 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US4790979A (en) * 1986-08-29 1988-12-13 Technimed Corporation Test strip and fixture
WO1990003771A1 (de) * 1988-10-12 1990-04-19 Martin Rahe Einrichtung zur aufnahme unkontrollierbar ausgeschiedenen urins
EP0729728A1 (de) * 1995-02-28 1996-09-04 AVL Medical Instruments AG Blutentnahmegerät
US5823973A (en) * 1995-09-08 1998-10-20 Integ, Inc. Needle assembly for fluid sampler
USD409758S (en) * 1998-01-14 1999-05-11 Accumetrics Sample cartridge
WO2000034775A1 (fr) * 1998-12-08 2000-06-15 Cohen Andre Dispositif jetable pour le prelevement d'un liquide biologique ou mineral avec detection et/ou dosage d'un parametre bien defini
US6120464A (en) * 1998-10-16 2000-09-19 Integ, Inc. Needle assembly for fluid sampler
US20020137998A1 (en) * 2001-03-26 2002-09-26 Wilson Smart Silicon microprobe with integrated biosensor
US20030018282A1 (en) * 2001-07-20 2003-01-23 Carlo Effenhauser System for withdrawing small amounts of body fluid
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US6612111B1 (en) * 2000-03-27 2003-09-02 Lifescan, Inc. Method and device for sampling and analyzing interstitial fluid and whole blood samples
US6660527B2 (en) 2002-03-28 2003-12-09 David Karl Stroup Fluid-transfer collection assembly and method of using the same
US20060200045A1 (en) * 2005-03-02 2006-09-07 Roe Steven N Dynamic integrated lancing test strip with sterility cover
US20070167869A1 (en) * 2005-03-02 2007-07-19 Roe Steven N System and method for breaking a sterility seal to engage a lancet
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US20080096750A1 (en) * 2006-10-20 2008-04-24 Navigant Biotechnologies, Llc Methods for Washing a Red Blood Cell Component and for Removing Prions Therefrom
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US20100050789A1 (en) * 2008-08-26 2010-03-04 Infusion Innovations, Inc. Finger Swipe Fluid-Transfer Collection Assembly and Method of Using the Same
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US9733805B2 (en) 2012-06-26 2017-08-15 Terumo Bct, Inc. Generating procedures for entering data prior to separating a liquid into components
US10004841B2 (en) 2013-12-09 2018-06-26 Michael C. Larson Blood purifier device and method
US10835678B2 (en) 2015-07-02 2020-11-17 Koska Family Limited Single use delivery device prefilled with a reconstitutable agent
US11382833B2 (en) 2016-04-25 2022-07-12 Koska Family Limited Systems and methods for fluid delivery
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

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US4763658A (en) * 1986-06-04 1988-08-16 Solutech, Inc. Dialysis system 2nd method
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CH543084A (de) 1973-10-15
NL7101448A (da) 1972-02-22
US3640393A (en) 1972-02-08
DK124170B (da) 1972-09-25
BE763805A (fr) 1971-09-06
CA933892A (en) 1973-09-18
BR7102250D0 (pt) 1973-04-12
GB1312498A (en) 1973-04-04
JPS4923429B1 (da) 1974-06-15
ZA708336B (en) 1971-09-29
AU2337570A (en) 1972-06-22
DE2101423A1 (da) 1972-02-24
CA933126A (en) 1973-09-04
FR2101378A5 (da) 1972-03-31

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