US3633027A - Mass spectrometer connected to a gap chromatograph through a valved molecule separator - Google Patents

Mass spectrometer connected to a gap chromatograph through a valved molecule separator Download PDF

Info

Publication number
US3633027A
US3633027A US23715A US3633027DA US3633027A US 3633027 A US3633027 A US 3633027A US 23715 A US23715 A US 23715A US 3633027D A US3633027D A US 3633027DA US 3633027 A US3633027 A US 3633027A
Authority
US
United States
Prior art keywords
separator
stage
mass spectrometer
ion source
nozzle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US23715A
Other languages
English (en)
Inventor
Erik Ragnar Ryhage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
LKB Produkter AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LKB Produkter AB filed Critical LKB Produkter AB
Application granted granted Critical
Publication of US3633027A publication Critical patent/US3633027A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7293—Velocity or momentum separators
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0422—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for gaseous samples

Definitions

  • GASCHROMATO GRAPH References Cited UNITED STATES PATENTS 3,471,692 10/ l 969 Llewellyn Q. 250/419 G 3,080,754 3/1963 Johnson 250/419 G FOREIGN PATENTS 221,621 7/1968 Sweden 250/419 G Primary ExaminerJames W. Lawrence Assistant Examiner-C. E. Church Attorney-Christen & Sabol AISTRAC'I: An instrument for analyzing organic chemical compounds is provided. The instrument comprises a gas chromatograph which via a molecule separator is connected to the ion source of a mass spectrometer. The separator consists of a number of series connected evacuating stages, each stage being connected to a vacuum pump. Each stage is provided with an input jet nozzle and a coaxial output nozzle, a slide being insertable between these nozzles in the first stage so as to make it possible to switch off the flow through the separator.
  • the present invention relates to an instrument for analyzing organic chemical compounds, the instrument comprising a gas chromatograph, a molecule separator and a mass spectrometer, the molecule separator being connected between the output of the gas chromatograph and the input of the ion source of the mass spectrometer, the separator including at least one separating stage consisting of an evacuation chamber connected to a vacuum pump, a jet input nozzle via which molecules in gas phase are supplied from the gas chromatograph and an output nozzle coaxial with the jet nozzle.
  • so called molecule separators are used for separating a carrier gas, usually helium, from the specimen to be analyzed and for reducing the pressure in the ion source of the mass spectrometer.
  • Becker-Ryhage-Separator differs from different kinds of separators from the so called Becker-Ryhage-Separator however having several advantages in comparison to the others.
  • the enrichment is high, the loss of specimen is small, the dead volume is small and the memory effect is negligible.
  • the Becker-Ryhage-Separator is generally made in two stages. In the first stage the pressure is reduced to 0.001 mm. Hg by an oil diffusion pump. In this way approximately 99 percent of the carrier gas is evacuated while at least 75 percent of the specimen remains. The pressure will then be further reduced at the ion source of the mass spectrometer.
  • FIG. 1 shows a two-stage separator according to the invention provided with a switching-off arrangement in the form of a slide;
  • FIG. 2 shows another embodiment of a two-stage separator according to the invention in which the second separator stage has been combined with the ion source.
  • reference 1 denotes a mounting flange for connection of a gas chromatograph G
  • reference 2 denotes the first separator stage
  • reference 3 denotes the second separator stage
  • reference 4 denotes the mounting flange oflthe ion source of the mass spectrometer M.
  • the input jet nozzle of the separator stages are denoted 5a and 5b respectively and the output nozzles are denoted 6a and 6!: respectively.
  • Reference 7 denotes the slide by means of which the gas flow can be switched off or at least be prevented from passing into the second separator stage.
  • Reference 8 denotes a bellows which controls the position of the slide 7
  • reference 9 denotes a knob for moving the bellows.
  • the slide can be set into two positions and 11b, which positions are adjusted by means of a screw 10.
  • References 12 and 13 denote connections leading to a mechanical vacuum pump and an oil diffusion pump respectively.
  • the slide 7 is inserted between the nozzles 5a and 6a.
  • the distance between these nozzles these about 0.1 mm. and thus the slide should have this dimension.
  • the nozzle 5a does also have a diameter of about 0.1 mm.
  • the slide does not necessarily have to seal this nozzle completely but a small leakage :into the separator housing can be permitted. It has turned out in practice that in spite of this leakage the mechanical vacuum pump provides a pressure which is sufficiently low for making the oil diffusion pump work and for not making it necessary to have the ion source switched off. Even if the pressure in the first separator stage 2 is as much as 1 mm. Hg, instead of the normal value 0.01 mm. Hg, the system works satisfactory. Thus the pumps do not have to be switched off.
  • the slide 7 can be shaped so as to seal only the output nozzle 6a.
  • the slide 7 could be provided with a slot in the surface turned to the input nozzle 5a. This shaping of the slide is suitable when a gas flow through only the gas chromatograph column is wanted, for instance after mounting the column.
  • the dead volume after the separator is reduced considerably.
  • the volume of the tap between the separator and the ion source is approximately 0.5 ml. and the connecting pipes have a volume of approximately the same size. If these values are compared with the area of the channel through the separator (0.8 mm?) and the area of the nozzle (0.008 mm?) the significanceof the reduced dead volume is understood.
  • a reduced volume after the separator means less than a reduced volume before the separator, the pressure conditions being completely different, but a reduced volume is still desirable.
  • the insertion of some sort of tap before the separator is not suitable as this will increase the dead volume.
  • Each person skilled within this field is aware of the drawbacks of such an arrangement, especially when capillary columns are used in the gas chromatograph.
  • a tap mounted before the separator further makes it more difficult to remove the flange for cleaning the nozzle 5a.
  • the other nozzles do not have to be cleaned so often as the pressure and thus the fouling is less at these nozzles.
  • the switching ofi' means consist of a slide.
  • the slide can of course be shaped in different ways and the insertion of the slide between the nozzles of the separator can be arranged in dif ferent ways. If only a sealing of the output nozzle is wanted it might thus be suitable to make the top of the output nozzle radially movable.
  • FIG. 2 a new way of connecting the separator to a mass spectrometer is shown.
  • This connection is made possible by using the present invention.
  • the references denote the same members as in FIG. 1, the difference being that reference 15 denotes the connection leading to the ion source and references 14a and Nb denote the nozzle of the second separator stage.
  • Reference 16 denotes the connection of the high vacuum system which in this case is the same for the second separator stage and the ion source housing. in this embodiment the dead volume is considerably decreased in comparison with the embodiment of FIG. 1. On the other hand the flexibility will be somewhat reduced.
  • An instrument for analyzing organic-chemical compounds comprising a gas chromatograph, a molecule separator and a mass spectrometer having a housing, the molecule separator being connected between the output of the gas chromatograph and the input of the ion source of the mass spectrometer, the molecule separator including at least one separating stage consisting of an evacuation chamber connected to a vacuum pump, a jet input nozzle from which molecules in gas phase are supplied from the gas chromatograph and an output nozzle coaxial with the jet nozzle, characterized in that the molecule separator comprises a slide element, and means mounting said slide element for movement in a direction transverse to the axis of said input of output nozzles so as to be inserted between the jet nozzle and the output nozzle to close the space therebetween and cut off the gas flow through the molecule separator and to be movable to another position to permit said gas flow.
  • An instrument according to claim 1 characterized in that the surface of said slide element is shaped to seal the output nozzle and to provide space for leakage at the jet input nozzle when the slide element is in an inserted position.
  • An instrument according to claim 1 characterized in, that the number of stages is at least two, the last stage being combined with the housing of the ion source.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
US23715A 1969-04-21 1970-03-30 Mass spectrometer connected to a gap chromatograph through a valved molecule separator Expired - Lifetime US3633027A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE05621/69A SE325726B (enrdf_load_stackoverflow) 1969-04-21 1969-04-21

Publications (1)

Publication Number Publication Date
US3633027A true US3633027A (en) 1972-01-04

Family

ID=20266851

Family Applications (1)

Application Number Title Priority Date Filing Date
US23715A Expired - Lifetime US3633027A (en) 1969-04-21 1970-03-30 Mass spectrometer connected to a gap chromatograph through a valved molecule separator

Country Status (4)

Country Link
US (1) US3633027A (enrdf_load_stackoverflow)
FR (1) FR2045486A5 (enrdf_load_stackoverflow)
GB (1) GB1267121A (enrdf_load_stackoverflow)
SE (1) SE325726B (enrdf_load_stackoverflow)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3842266A (en) * 1973-04-11 1974-10-15 Us Air Force Atmospheric sampling probe for a mass spectrometer
JPS5011582U (enrdf_load_stackoverflow) * 1973-05-28 1975-02-06
JPS5047697A (enrdf_load_stackoverflow) * 1973-08-27 1975-04-28
JPS5063489U (enrdf_load_stackoverflow) * 1973-10-12 1975-06-09
US4016421A (en) * 1975-02-13 1977-04-05 E. I. Du Pont De Nemours And Company Analytical apparatus with variable energy ion beam source
US4298795A (en) * 1978-09-08 1981-11-03 Japan Spectroscopic Co. Ltd Method and apparatus for introducing samples to a mass spectrometer
US4629478A (en) * 1984-06-22 1986-12-16 Georgia Tech Research Corporation Monodisperse aerosol generator
US4687929A (en) * 1984-06-22 1987-08-18 Georgia Tech Research Corporation Monodisperse aerosol generator
US4762995A (en) * 1984-06-22 1988-08-09 Georgia Tech Research Corporation Monodisperse aerosol generator
US4791292A (en) * 1986-04-24 1988-12-13 The Dow Chemical Company Capillary membrane interface for a mass spectrometer
US4924097A (en) * 1984-06-22 1990-05-08 Georgia Tech Rss. Corp Monodisperse aerosol generator for use with infrared spectrometry
US5024952A (en) * 1989-06-26 1991-06-18 Union Carbide Chemicals And Plastics Technology Corporation Method for obtaining analytes from liquid menstrua for analysis
US5137553A (en) * 1990-03-02 1992-08-11 Sge International Pty. Ltd. Molecular jet separator
WO1997036177A1 (de) * 1996-03-27 1997-10-02 Balzers Aktiengesellschaft Anordnung zum verbinden eines tiefdruckeinganges eines gasanalysegerätes
US20070205362A1 (en) * 2006-03-03 2007-09-06 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US20080067348A1 (en) * 2006-05-26 2008-03-20 Ionsense, Inc. High resolution sampling system for use with surface ionization technology
US20080087812A1 (en) * 2006-10-13 2008-04-17 Ionsense, Inc. Sampling system for containment and transfer of ions into a spectroscopy system
US20080191412A1 (en) * 2007-02-09 2008-08-14 Primax Electronics Ltd. Automatic document feeder having mechanism for releasing paper jam
US20090090858A1 (en) * 2006-03-03 2009-04-09 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8440965B2 (en) 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8754365B2 (en) 2011-02-05 2014-06-17 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
US10825673B2 (en) 2018-06-01 2020-11-03 Ionsense Inc. Apparatus and method for reducing matrix effects
US11424116B2 (en) 2019-10-28 2022-08-23 Ionsense, Inc. Pulsatile flow atmospheric real time ionization
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080754A (en) * 1961-07-10 1963-03-12 Charles Y Jolmson Direct method of measuring neutral gas temperatures
US3471692A (en) * 1967-03-27 1969-10-07 Varian Associates Gas analyzer system employing a gas chromatograph and a mass spectrometer with a gas switch therebetween

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3080754A (en) * 1961-07-10 1963-03-12 Charles Y Jolmson Direct method of measuring neutral gas temperatures
US3471692A (en) * 1967-03-27 1969-10-07 Varian Associates Gas analyzer system employing a gas chromatograph and a mass spectrometer with a gas switch therebetween

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3842266A (en) * 1973-04-11 1974-10-15 Us Air Force Atmospheric sampling probe for a mass spectrometer
JPS5011582U (enrdf_load_stackoverflow) * 1973-05-28 1975-02-06
JPS5047697A (enrdf_load_stackoverflow) * 1973-08-27 1975-04-28
JPS5063489U (enrdf_load_stackoverflow) * 1973-10-12 1975-06-09
US4016421A (en) * 1975-02-13 1977-04-05 E. I. Du Pont De Nemours And Company Analytical apparatus with variable energy ion beam source
US4298795A (en) * 1978-09-08 1981-11-03 Japan Spectroscopic Co. Ltd Method and apparatus for introducing samples to a mass spectrometer
US4629478A (en) * 1984-06-22 1986-12-16 Georgia Tech Research Corporation Monodisperse aerosol generator
US4687929A (en) * 1984-06-22 1987-08-18 Georgia Tech Research Corporation Monodisperse aerosol generator
US4762995A (en) * 1984-06-22 1988-08-09 Georgia Tech Research Corporation Monodisperse aerosol generator
US4924097A (en) * 1984-06-22 1990-05-08 Georgia Tech Rss. Corp Monodisperse aerosol generator for use with infrared spectrometry
US4791292A (en) * 1986-04-24 1988-12-13 The Dow Chemical Company Capillary membrane interface for a mass spectrometer
US5024952A (en) * 1989-06-26 1991-06-18 Union Carbide Chemicals And Plastics Technology Corporation Method for obtaining analytes from liquid menstrua for analysis
US5137553A (en) * 1990-03-02 1992-08-11 Sge International Pty. Ltd. Molecular jet separator
WO1997036177A1 (de) * 1996-03-27 1997-10-02 Balzers Aktiengesellschaft Anordnung zum verbinden eines tiefdruckeinganges eines gasanalysegerätes
US6310340B1 (en) 1996-03-27 2001-10-30 Unaxis Balzers Aktiengesellschaft Arrangement for connecting a low-pressure inlet of a gas analyzer
US20070205362A1 (en) * 2006-03-03 2007-09-06 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8525109B2 (en) 2006-03-03 2013-09-03 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8497474B2 (en) 2006-03-03 2013-07-30 Ionsense Inc. Sampling system for use with surface ionization spectroscopy
US20100102222A1 (en) * 2006-03-03 2010-04-29 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8217341B2 (en) 2006-03-03 2012-07-10 Ionsense Sampling system for use with surface ionization spectroscopy
US8026477B2 (en) 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US20090090858A1 (en) * 2006-03-03 2009-04-09 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
EP1992005A4 (en) * 2006-03-03 2010-02-03 Ionsense Inc SAMPLING SYSTEM FOR USE WITH SURFACE IONIZATION SPECTROSCOPY
US7700913B2 (en) 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8421005B2 (en) 2006-05-26 2013-04-16 Ionsense, Inc. Systems and methods for transfer of ions for analysis
US20080067359A1 (en) * 2006-05-26 2008-03-20 Ionsense, Inc. Flexible open tube sampling system for use with surface ionization technology
US7714281B2 (en) 2006-05-26 2010-05-11 Ionsense, Inc. Apparatus for holding solids for use with surface ionization technology
US20080067348A1 (en) * 2006-05-26 2008-03-20 Ionsense, Inc. High resolution sampling system for use with surface ionization technology
US20100140468A1 (en) * 2006-05-26 2010-06-10 Ionsense, Inc. Apparatus for holding solids for use with surface ionization technology
US7777181B2 (en) 2006-05-26 2010-08-17 Ionsense, Inc. High resolution sampling system for use with surface ionization technology
US20080067358A1 (en) * 2006-05-26 2008-03-20 Ionsense, Inc. Apparatus for holding solids for use with surface ionization technology
US8481922B2 (en) 2006-05-26 2013-07-09 Ionsense, Inc. Membrane for holding samples for use with surface ionization technology
US7705297B2 (en) 2006-05-26 2010-04-27 Ionsense, Inc. Flexible open tube sampling system for use with surface ionization technology
US8440965B2 (en) 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US20080087812A1 (en) * 2006-10-13 2008-04-17 Ionsense, Inc. Sampling system for containment and transfer of ions into a spectroscopy system
US7928364B2 (en) 2006-10-13 2011-04-19 Ionsense, Inc. Sampling system for containment and transfer of ions into a spectroscopy system
US20080191412A1 (en) * 2007-02-09 2008-08-14 Primax Electronics Ltd. Automatic document feeder having mechanism for releasing paper jam
US7726650B2 (en) 2007-02-09 2010-06-01 Primax Electroncs Ltd. Automatic document feeder having mechanism for releasing paper jam
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
US8563945B2 (en) 2009-05-08 2013-10-22 Ionsense, Inc. Sampling of confined spaces
US8729496B2 (en) 2009-05-08 2014-05-20 Ionsense, Inc. Sampling of confined spaces
US10643834B2 (en) 2009-05-08 2020-05-05 Ionsense, Inc. Apparatus and method for sampling
US10090142B2 (en) 2009-05-08 2018-10-02 Ionsense, Inc Apparatus and method for sampling of confined spaces
US8895916B2 (en) 2009-05-08 2014-11-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9633827B2 (en) 2009-05-08 2017-04-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9390899B2 (en) 2009-05-08 2016-07-12 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9224587B2 (en) 2011-02-05 2015-12-29 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US8754365B2 (en) 2011-02-05 2014-06-17 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US11742194B2 (en) 2011-02-05 2023-08-29 Bruker Scientific Llc Apparatus and method for thermal assisted desorption ionization systems
US8963101B2 (en) 2011-02-05 2015-02-24 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US9514923B2 (en) 2011-02-05 2016-12-06 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US11049707B2 (en) 2011-02-05 2021-06-29 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US10643833B2 (en) 2011-02-05 2020-05-05 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US8822949B2 (en) 2011-02-05 2014-09-02 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US9960029B2 (en) 2011-02-05 2018-05-01 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US9105435B1 (en) 2011-04-18 2015-08-11 Ionsense Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US10283340B2 (en) 2014-06-15 2019-05-07 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US10553417B2 (en) 2014-06-15 2020-02-04 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US9824875B2 (en) 2014-06-15 2017-11-21 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US10056243B2 (en) 2014-06-15 2018-08-21 Ionsense, Inc. Apparatus and method for rapid chemical analysis using differential desorption
US10825675B2 (en) 2014-06-15 2020-11-03 Ionsense Inc. Apparatus and method for generating chemical signatures using differential desorption
US9558926B2 (en) 2014-06-15 2017-01-31 Ionsense, Inc. Apparatus and method for rapid chemical analysis using differential desorption
US11295943B2 (en) 2014-06-15 2022-04-05 Ionsense Inc. Apparatus and method for generating chemical signatures using differential desorption
US9337007B2 (en) 2014-06-15 2016-05-10 Ionsense, Inc. Apparatus and method for generating chemical signatures using differential desorption
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
US10825673B2 (en) 2018-06-01 2020-11-03 Ionsense Inc. Apparatus and method for reducing matrix effects
US11424116B2 (en) 2019-10-28 2022-08-23 Ionsense, Inc. Pulsatile flow atmospheric real time ionization
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization

Also Published As

Publication number Publication date
DE2014459B2 (de) 1976-05-06
SE325726B (enrdf_load_stackoverflow) 1970-07-06
GB1267121A (enrdf_load_stackoverflow) 1972-03-15
DE2014459A1 (de) 1970-11-05
FR2045486A5 (enrdf_load_stackoverflow) 1971-02-26

Similar Documents

Publication Publication Date Title
US3633027A (en) Mass spectrometer connected to a gap chromatograph through a valved molecule separator
US6583409B2 (en) Mass analysis apparatus and method for mass analysis
US9627189B2 (en) Vacuum system
EP2463891B1 (en) Miniature mass spectrometer system
US7582861B2 (en) Mass spectrometer
CA2162856A1 (en) Method of plasma mass analysis with reduced space charge effects
GB2489623A (en) Multi-pressure stage mass spectrometer
JP2713506B2 (ja) 同位体存在比プラズマ源質量分析計
US11658019B2 (en) IMR-MS reaction chamber
US11328919B2 (en) Two-stage ion source comprising closed and open ion volumes
JP7047936B2 (ja) 質量分析装置
CN110706998A (zh) 一种双离子源双通道质谱仪
US3398505A (en) Dual stage membrane gas separators with variable conductance means for varying their throughput
US6060706A (en) Analytical apparatus using ion trap mass spectrometer
US3842266A (en) Atmospheric sampling probe for a mass spectrometer
US5164593A (en) Mass spectrometer system including an ion source operable under high pressure conditions, and a two-stage pumping arrangement
Verge et al. Plasticizer contamination from vacuum system O-rings in a quadrupole ion trap mass spectrometer
US3751880A (en) Carrier gas separating unit
CN110462784B (zh) 质量分析装置和管嘴部件
US3673405A (en) Gas inlet system for a mass spectrometer
US2618750A (en) Apparatus for supplying charge material to mass spectrometers
SU1441304A1 (ru) Магнетронный детектор по захвату электронов
JPS648786B2 (enrdf_load_stackoverflow)
JP2024064401A (ja) 質量分析装置
CN114171369A (zh) 一种多离子源质谱仪器