US3624219A - Plaque-disclosing composition and package system - Google Patents

Plaque-disclosing composition and package system Download PDF

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US3624219A
US3624219A US3624219DA US3624219A US 3624219 A US3624219 A US 3624219A US 3624219D A US3624219D A US 3624219DA US 3624219 A US3624219 A US 3624219A
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plaque
aerosol
disclosing
dye
composition
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Max J Perlitsh
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Max J Perlitsh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K8/00Cosmetics or similar toilet preparations
    • A61K8/18Cosmetics or similar toilet preparations characterised by the composition
    • A61K8/30Cosmetics or similar toilet preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42Colour properties
    • A61K2800/43Pigments; Dyes

Abstract

A plaque-disclosing formulation suitable for use in aerosol form without causing undue ''''cold-sensitivity'''' -related pain to a patient. The formulation comprises a specially selected dye such as Erythrosine B, and an active solvent like ethanol to aid penetration of the dye into the plaque deposit. It is incorporated into an aerosol charge which comprises a Freon-type propellant in a quantity which contributes less than 50 B.t.u. heat of evaporation per pound of total aerosol charge at one atmosphere. It is advantageously packaged in an aerosol-type container equipped with a meter-type valve rated for discharging less than about 70 milligrams per shot. The container should be equipped with a discharge conduit of from 1.5 to 2.5 inches in length and a bore size of from about 0.010 to about 0.03 inches in diameter.

Description

United States Patent Max J. Perlitsh 20 Everett Ave., Winchester, Mass. 01890 [211 App]. No. 53,519

[22] Filed July 6, 1970 [45] Patented Nov. 30, 1971 [72] lnventor [56] References Cited UNITED STATES PATENTS 1,112,180 9/1914 Westenfelter Primary Examiner-Shep K. Rose Attorney-Cesari and McKenna ABSTRACT: A plaque-disclosing formulation suitable for use in aerosol form without causing undue "cold-sensitivity -related pain to a patient. The formulation comprises a specially selected dye such as Erythrosine B, and an active solvent like ethanol to aid penetration of the dye into the plaque deposit. It is incorporated into an aerosol charge which comprises a Freon-type propellant in a quantity which contributes less than 50 B.t.u. heat of evaporation per pound of total aerosol charge at one atmosphere. It is advantageously packaged in an aerosol-type container equipped with a meter-type valve rated for discharging less than about 70 milligrams per shot. The container should be equipped with a discharge conduit of from 1.5 to 2.5 inches in length'and a bore size of from about 0.010 to about 0.03 inches in diameter.

PATENIEU NUV30 IQYI FIG. 1

MAX J. PERLITSCH lnven/or CESAR! 8 MCKENNA A horneys PLAQUE-DISCLOSING COMPOSITION AND PACKAGE SYSTEM BACKGROUND OF THE INVENTION A number of diseases of the teeth and/or gums are related to 5 the presence of certain types of bacteria found in the mouth. Tooth decay as manifested by cavities and pyorrhea are common examples of bacteria-caused dental diseases.

The harmful bacteria tend to attach themselves to the teeth 10 the mouth. This acid production will normally continue in and l5 on the bacterial deposit for a considerable time after the sugar has been eaten, causing tooth decay.

Plaque, if not removed from the mouth, will eventually form a relatively hard, tenaciously adherent deposit called calculus or tartar. This calculus deposit itself becomes a favorable en- 2 vironment for the colonization of more bacteria and, consequently, the size of the calculus deposit tends to increase as further layers of plaque form and calcify thereon. Eventually this calculus and plaque cause irritation which leads to infection of the gum tissue. Although the earliest manifestation of such irritation and infection may be bleeding of gum tissue, the infection will eventually reach the bone that supports the teeth and contribute to a progressive loss of the bone support of the teeth and, consequently, to the loss of the teeth.

For these reasons, plaque-control is becoming recognized as a basic requirement of preventive dentistry. It has become recognized that, by frequently removing dental plaque from his teeth, a person will be able to effectively avoid the two most common dental diseases such as tooth decay and pyorrhea.

The growth of plaque and the subsequent buildup of calculus deposits, can be avoided by proper oral hygiene practices which may be carried out by a person on his own teeth. Of course such self-care pre-assumes that a person start with relatively clean teeth, i.e., teeth from which plaque and calculus deposits have been recently cleaned. Such self-care also preassumes the ability by the person to identify those portions of his mouth where the plaque is beginning to build up once again. ln this connection, it is to be emphasized that plaque is sufficiently adhesive that normal nonlocalized care is ineffective and burdensome to a person wishing to remove plaque from selected locations in his mouth. Unfortunately plaque is difficult to see even on the exposed surfaces of the teeth because it is usually deposited in a colorless and transparent form. Therefore it has been generally regarded to be desirable to use plaque disclosing" compositions to identify areas of the mouth where plaque buildup is a problem.

Among suggested plaque disclosing compositions have been solutions of basic fuschsin dye which have been painted on the tooth surface with cotton applicators. These solutions have the general drawback of being nondiscriminating discriminating in that they tend to stain other parts of the mouth as well as plaque deposits for up to several hours after use. This presents a real problem in terms of acceptance because of the cosmetic problems presented to the user.

Another attempted solution to the problem has been the incorporation of various dyes in chewable wafers. Frequently such wafers do not develop sufficient concentration of dye to stain the plaque deposits. Moreover, the activity of the dye compositions generated in the mouth is so low that the dye does not adequately penetrate the plaque deposit and they are not detected by the user of the wafer. Thus a person can easily be misled into believing he has cleaned the plaque from his teeth when such, in fact, is not the case. It remains a problem, then, to provide people with plaque-disclosing means that can be conveniently and effectively used by people without a detrimental cosmetic effect.

SUMMARY OF THE INVENTION It is an object of the invention to provide an improved plaque-disclosing means which selectively identifies areas of plaqueformation on all tooth surfaces.

It is another object of the invention to provide an improved plaque-disclosing composition which combines the ability to penetrate plaque deposits and yet is susceptible to relatively easy removal from the mouth by washing and rinsing after use.

Another object of the invention is to provide a novel process for safely and easily applying plaque-disclosing compositions in such a way as to assure the discrimination between plaque-contaminated and plaque free surfaces.

A further object of the invention is to provide a suitable dispenser for use in the aforesaid process.

Still another object of the invention is to achieve a means for applying a plaque-disclosing composition in a spray form while substantially achieving the above objects, but without causing pain to the patient because of cold-sensitivity of the 0 teeth.

Other objects of the invention will be obvious to those skilled in the art on reading the instant invention.

The above objects have been substantially achieved by the formulation of an improved plaque-disclosing formulation and the incorporation of this formulation in a novel composition suitable for application as an aerosol spray. The aerosol composition comprises a carefully selected propellant which gives adequate spray coverage with a minimum of interference with the plaque-disclosing formulation yet evaporates in such a way as to minimize the discomfort of patients having cold-sensitivity problems.

The plaque-disclosing formulation includes a dye, and a solvent which is adapted to dissolve the dye and to aid the penetration of the dye into the plaque deposit.

The most advantageous dye for use in the plaque-disclosing formulation is selected from those dyes such as Erythrosine B. This dye is an acid red dye of the Xanthene type which is further identified as F.D. & C. Red No. 3 and Dye No. 45430 in the Color Index.

Erythrosine B exhibits a significantly superior performance over such dyes as basic fuchsin which stains so intensively that an excessively prolonged staining effect is realized. Moreover, such dyes as amaranth and Brilliant Blue are excessively water soluble and neither penetrate nor persist in the mouth to the degree desirable for plaque-disclosing purposes.

It has been found that from about 0.5 percent to 10 percent by weight of dyestuff should be used in the plaque-disclosing composition, most advantageously about 1.5 to 3 percent. The balance of the plaque-disclosing composition is the solvent for the dye.

The solvent must, of course, be selected from those that are physiologically tolerable with reference to the particular oral utility of the invention. The solvent must also provide a major portion of a more active component to facilitate the solution of a dye (which must have some resistance to water leaching) and to aid the penetration of the dye into plaque deposits. The use of a physiologically intolerable aliphatic hydroxy compound such as ethanol is particularly advantageous. ln addition to this more active component, the solvent should comprise a substantial quantity of water to facilitate removal of the dyestuff from the areas of the mouth where the more active solvent component does not find plaque deposits into which it carries the dyestuff. Other water-soluble, physiologically tolerable solvents such as glycerine can be used although the ethanol-water system gives the best balance between plaque discrimination and dye penetration under most conditions of use.

In summary the plaque-disclosing formulation comprises a dyestuff, a solvent comprising a more active component (or penetrant) such as ethyl alcohol and a less active component such as water. The plaque-disclosing formulation most advantageously used with Erythrosine B is a mixture of aliphatic alcohol, preferably ethanol, and water.

The total aerosol composition comprises a carefully selected propellant to act as a carrier of the plaque-disclosing formulation. This propellant must be carefully selected to avoid causing pain to those patients having what is known to dentists as cold-sensitivity." To this end, it is advantageous that the propellant have a maximum heat of evaporation of about 50 B.t.u. per pound of total aerosol composition at l atmosphere of pressure. It is advantageous for this value-which is a measure of the cooling capacity of the solvent-to be much closer to 20 B.t.u. per pound of aerosol composition charge.

The propellant system, of course must be one which lacks toxic characteristics. A particularly advantageous propellant system conforming to the criteria set forth above and selected from the halogen-substituted hydrocarbon-type compounds available from E.1. DuPont de Nemours Company under the trade designation Freon. Among such systems would be a 60:40 mixture of CCllflCClF and CCI F or plain CCl F each, of course, taken in an appropriate quantity.

The total propellant forms about 30 to 60 percent of the entire aerosol spray composition with the more advantageous range being from about 30 to 50 percent. The lower quantity reduces the amount of gas which must be dissipated from the sometimes restricted volume adjacent the discharge point.

The means by which the above-disclosed aerosol formulation is delivered to the desired surfaces inside the mouth has been found to be important, not only to allow manipulative convenience in applying the plaque-disclosing solution to a particular tooth surface within the mouth, but also to provide a means to further reduce the cold-sensitivity problem by preconditioning and moderating the precise rate at which the aerosol solution is discharged from the device. ln this regard, it has been discovered that single discharges of aerosol composition should be made in quantities of from about 20 to about 70 milligrams with the lower discharges being preferred.

Moreover, the length of the applicator arm and bore therein have been found to provide the most advantageous spray when so designated as to be from about 1.5 inches to 2.5 inches in length and having a bore size of from about 0.010 inch to about 0.03 inch. These bore sizes and length provide a balance between velocity and shape of the spray as it leaves the bore discharge and aid in obtaining not only the desired directional effect but a suitable evaporation of propellant before the spray hits the tooth surface.

ILLUSTRATIVE EXAMPLE OF THE INVENTION EXAMPLE 1 The following aerosol composition was prepared:

1 by welght Erythrosine B Dye 1 Delomzed water 1 S Ethanol solvent 37 5 Freon l2 (CCIJQ) 20,0 Freon 114(CC1F,CC1F,1 30.0

The solvent (SDA 38 8) used was a preflavored solvent conforming to the Standurds for Denatured Alcohol 38 B per the Food the Drug Administration standards This aerosol composition was charged into an aerosol package 10, as shown in P16. 1, comprising an Emson ASD-l valve actuator 11 and a valve system which metered 50 milligrams of material 13 through a 2.25-inch arm 12 having a 0.018-inch bore 14 therein. Arm 12 is fitted with a protective cap 16. The resulting package assembly provides a sealed nonbreakable package which can easily be used to apply the plaque-disclosing composition in a high concentration to a localized and preselected area. Moreover, the container is substantially air free, thereby assuring minimum oxidative degradation of the dyestuff. The velocity imparted by the propellant to the alcohol-dye allowed the instantaneous disclosure of the plaque deposits without risk of "false-negatives" of the type frequently encountered when so-called disclosing-wafers are used.

EXAMPLE 2 The following aerosol charge was prepared:

This material had the advantages of the composition disclosed in example 1 except that it was improved with respect to limiting undesirable responses to cold sensitivity because of the lower concentration of propellant. The latent heat of evaporation was only about 24 B.t.u. per lb. of aerosol charge. Therefore the propellant flashed off as it came from the nozzle with minimum of local cooling effect.

It is to be understood that the following claims are intended to cover all of the generic and specific features of the invention herein described.

What is claimed is:

l. A plaque-disclosing aerosol dispenser package equipped with a metering valve and a discharge arm having a bore size and length forming means to provide a suitable evaporation and dissipation of propellent gas before aerosol spray discharged therefrom hits a tooth surface, said package con taining a composition comprising (A) Erythrosin B as the essential plaque-disclosing dye, (B) a physiologically tolerable solvent therefore consisting of:

l a major quantity of plaque-penetrating alcohol and 2. a minor quantity of water in admixture with (C) an effective quantity of nontoxic halogenated hydrocarbon propellant, said propellant contributing not above 50 B.T.U.s of heat of evaporation to each pound of the total aerosol formulation, said composition being substantially free of excessively prolonged and insufficiently persistent plaque-disclosing dyes and being free of propellants contributing sufficient heat of evaporation to cause painful sensation on teeth.

2. A plaque-disclosing composition as defined in claim 1 wherein said dye forms from 0.5 to 10 percent of said composition and said alcohol is ethanol.

3. A plaque-disclosing composition as defined in claim 2 wherein the weight ratio of ethanolzwater is at least 2:1 and the dye forms from 1.5 to 3 percent of said composition.

4. A process for the selective disclosure of plaque deposits by aerosol techniques without subjecting a patient to pain caused by localized cooling, said process comprising the steps of spraying a discharge of an effective amount of a dye-bearing solution as defined in claim 1 from the discharge arm of the aerosol dispenser package of claim 1.

5. A process as defined in claim 4 wherein said dye is Erythrosyne B, and wherein said active solvent component is ethanol.

6. A dispenser package as defined in claim 1 useful in the selective disclosure of plaque deposits by aerosol techniques and comprising the plaque-disclosing aerosol formulation in an aerosol dispenser equipped with a metering valve capable of ejecting from about 20 to about 70 milligrams of said formulation per discharge and equipped with a discharge arm of from 1.5 to 2.5 inches in length having therein a conduit bore 5 of from 0.01 inch to about 0.03 inches in diameter.

Claims (6)

  1. 2. a minor quantity of water in admixture with (C) an effective quantity of nontoxic halogenated hydrocarbon propellant, said propellant contributing not above 50 B.t.u.s of heat of evaporation to each pound of the total aeRosol formulation, said composition being substantially free of excessively prolonged and insufficiently persistent plaque-disclosing dyes and being free of propellants contributing sufficient heat of evaporation to cause painful sensation on teeth.
  2. 2. A plaque-disclosing composition as defined in claim 1 wherein said dye forms from 0.5 to 10 percent of said composition and said alcohol is ethanol.
  3. 3. A plaque-disclosing composition as defined in claim 2 wherein the weight ratio of ethanol:water is at least 2:1 and the dye forms from 1.5 to 3 percent of said composition.
  4. 4. A process for the selective disclosure of plaque deposits by aerosol techniques without subjecting a patient to pain caused by localized cooling, said process comprising the steps of spraying a discharge of an effective amount of a dye-bearing solution as defined in claim 1 from the discharge arm of the aerosol dispenser package of claim 1.
  5. 5. A process as defined in claim 4 wherein said dye is Erythrosyne B, and wherein said active solvent component is ethanol.
  6. 6. A dispenser package as defined in claim 1 useful in the selective disclosure of plaque deposits by aerosol techniques and comprising the plaque-disclosing aerosol formulation in an aerosol dispenser equipped with a metering valve capable of ejecting from about 20 to about 70 milligrams of said formulation per discharge and equipped with a discharge arm of from 1.5 to 2.5 inches in length having therein a conduit bore of from 0.01 inch to about 0.03 inches in diameter.
US3624219D 1970-07-06 1970-07-06 Plaque-disclosing composition and package system Expired - Lifetime US3624219A (en)

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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105758A (en) * 1976-12-27 1978-08-08 Colgate-Palmolive Company Oral compositions containing an anticalculus agent
US4150106A (en) * 1978-02-16 1979-04-17 Cooper S.A. Toothpaste permitting of controlling the tooth brushing time
US4302439A (en) * 1976-04-07 1981-11-24 Selwyn Stephen L Method of disclosing dental plaque with D and C Red 33
US4431628A (en) * 1978-04-07 1984-02-14 Colgate-Palmolive Company Natural dye indicator for dental plaque
US4457711A (en) * 1980-05-12 1984-07-03 Maloney Holly H Pressurized oral spraying device
US4678658A (en) * 1985-05-24 1987-07-07 Larry Casey Aerosol germicide and dye
US4793988A (en) * 1985-05-24 1988-12-27 Irene Casey Germicide and dye composition
US4965063A (en) * 1985-05-24 1990-10-23 Irene Casey Cleaner and disinfectant with dye
US4992256A (en) * 1989-09-27 1991-02-12 Colgate-Palmolive Company Plaque disclosing compositions
US5082444A (en) * 1989-04-10 1992-01-21 Rhoades Clark J Portable pressurized pulsed oralcavity cleaner
US5147075A (en) * 1988-10-03 1992-09-15 Falcon Safety Products Incorporated Actuating mechanism for pressurized fluid containers and nozzle assembly
US5611690A (en) * 1996-04-02 1997-03-18 E. Mishan & Sons, Inc. Method and apparatus for sprayed delivery of tooth bleaching agent
US20040002132A1 (en) * 2002-06-19 2004-01-01 Ribeiro De Nazare Raimunda Fatima Bacterial plaque evidencing composition based on natural colorants
US20070237726A1 (en) * 2006-04-07 2007-10-11 The Procter & Gamble Company Oral care regimens and kits
US20120003601A1 (en) * 2009-12-15 2012-01-05 Massachusetts Institute Of Technology Jet Injector Use In Oral Evaluation
US9308326B2 (en) 2005-02-11 2016-04-12 Massachusetts Institute Of Technology Controlled needle-free transport
US9517030B2 (en) 2009-09-01 2016-12-13 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US9999686B2 (en) 2012-09-11 2018-06-19 Slh Optimal Health Llc Dental cleaning composition

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1112180A (en) * 1913-03-08 1914-09-29 Charles W Westenfelter Dentifrice.
US1717723A (en) * 1927-04-09 1929-06-18 Calsodent Company Inc Means for and method of detecting and correcting mouth acidity
US2151495A (en) * 1937-04-05 1939-03-21 David V Bender Disclosing solution
US3279068A (en) * 1964-01-23 1966-10-18 Barnes Hind Pharm Inc Method of detecting carious tissue
US3309274A (en) * 1962-07-23 1967-03-14 Brilliant Herbert Use of fluorescent dyes in dental diagnostic methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1112180A (en) * 1913-03-08 1914-09-29 Charles W Westenfelter Dentifrice.
US1717723A (en) * 1927-04-09 1929-06-18 Calsodent Company Inc Means for and method of detecting and correcting mouth acidity
US2151495A (en) * 1937-04-05 1939-03-21 David V Bender Disclosing solution
US3309274A (en) * 1962-07-23 1967-03-14 Brilliant Herbert Use of fluorescent dyes in dental diagnostic methods
US3279068A (en) * 1964-01-23 1966-10-18 Barnes Hind Pharm Inc Method of detecting carious tissue

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302439A (en) * 1976-04-07 1981-11-24 Selwyn Stephen L Method of disclosing dental plaque with D and C Red 33
US4105758A (en) * 1976-12-27 1978-08-08 Colgate-Palmolive Company Oral compositions containing an anticalculus agent
US4150106A (en) * 1978-02-16 1979-04-17 Cooper S.A. Toothpaste permitting of controlling the tooth brushing time
US4431628A (en) * 1978-04-07 1984-02-14 Colgate-Palmolive Company Natural dye indicator for dental plaque
US4457711A (en) * 1980-05-12 1984-07-03 Maloney Holly H Pressurized oral spraying device
US4678658A (en) * 1985-05-24 1987-07-07 Larry Casey Aerosol germicide and dye
US4793988A (en) * 1985-05-24 1988-12-27 Irene Casey Germicide and dye composition
US4965063A (en) * 1985-05-24 1990-10-23 Irene Casey Cleaner and disinfectant with dye
US5147075A (en) * 1988-10-03 1992-09-15 Falcon Safety Products Incorporated Actuating mechanism for pressurized fluid containers and nozzle assembly
US5082444A (en) * 1989-04-10 1992-01-21 Rhoades Clark J Portable pressurized pulsed oralcavity cleaner
US4992256A (en) * 1989-09-27 1991-02-12 Colgate-Palmolive Company Plaque disclosing compositions
US5611690A (en) * 1996-04-02 1997-03-18 E. Mishan & Sons, Inc. Method and apparatus for sprayed delivery of tooth bleaching agent
US20040002132A1 (en) * 2002-06-19 2004-01-01 Ribeiro De Nazare Raimunda Fatima Bacterial plaque evidencing composition based on natural colorants
US7182935B2 (en) 2002-06-19 2007-02-27 Empresa Brasileira De Pesquisa Agropecuaria Embrapa Bacterial plaque evidencing composition based on natural colorants
US10326347B2 (en) 2005-02-11 2019-06-18 Massachusetts Institute Of Technology Controlled needle-free transport
US9308326B2 (en) 2005-02-11 2016-04-12 Massachusetts Institute Of Technology Controlled needle-free transport
US20070237726A1 (en) * 2006-04-07 2007-10-11 The Procter & Gamble Company Oral care regimens and kits
US9517030B2 (en) 2009-09-01 2016-12-13 Massachusetts Institute Of Technology Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties
US20120003601A1 (en) * 2009-12-15 2012-01-05 Massachusetts Institute Of Technology Jet Injector Use In Oral Evaluation
US9333060B2 (en) 2009-12-15 2016-05-10 Massachusetts Institute Of Technology Plaque removal and differentiation of tooth and gum
US9999686B2 (en) 2012-09-11 2018-06-19 Slh Optimal Health Llc Dental cleaning composition

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