US3596673A - Automatic transfer apparatus - Google Patents

Automatic transfer apparatus Download PDF

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Publication number
US3596673A
US3596673A US793498*A US3596673DA US3596673A US 3596673 A US3596673 A US 3596673A US 3596673D A US3596673D A US 3596673DA US 3596673 A US3596673 A US 3596673A
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US
United States
Prior art keywords
container
tube
liquid sample
support
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US793498*A
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English (en)
Inventor
Robert Laucournet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
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Publication of US3596673A publication Critical patent/US3596673A/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/18—Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2496—Self-proportioning or correlating systems
    • Y10T137/2514—Self-proportioning flow systems
    • Y10T137/2516—Interconnected flow displacement elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/2931—Diverse fluid containing pressure systems
    • Y10T137/3115—Gas pressure storage over or displacement of liquid
    • Y10T137/3127—With gas maintenance or application
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7287—Liquid level responsive or maintaining systems
    • Y10T137/7306—Electrical characteristic sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7287—Liquid level responsive or maintaining systems
    • Y10T137/7313—Control of outflow from tank
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/86236—Tank with movable or adjustable outlet or overflow pipe
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T74/00—Machine element or mechanism
    • Y10T74/18—Mechanical movements
    • Y10T74/18568—Reciprocating or oscillating to or from alternating rotary
    • Y10T74/18832—Reciprocating or oscillating to or from alternating rotary including flexible drive connector [e.g., belt, chain, strand, etc.]

Definitions

  • the present invention relates to an apparatus for the automatic transfer of a given quantity of liquid from a container wherein it is stored to another container and, more particularly, to the analysis of a calibrated quantity of the liquid.
  • the present invention provides an apparatus for the automatic transfer of a calibrated quantity of samples, for example blood samples for automatic analysis, while avoiding the contamination of a liquid sample with another and external pollution.
  • the present invention also provides an apparatus for the rapid transfer of a calibrated quantity of samples without taking particles in suspension from a phase known as the sedimented phase of the said sample.
  • the automatic transfer apparatus has a quantity of liquid sample contained in a first container for transfer to a second container.
  • a first tube has ends adapted to be immersed respectively in the sample and directed to the second container.
  • a second tube is connected to a source of gas under pressure with the free end adapted to penetrate into the said first container.
  • Means for detecting the passage of the liquid sample are provided at a given point of the first tube.
  • the ends of the first and second tubes which penetrate into the first container are fixed to the same support which itself is mobile is translational movement relative to the level of the liquid sample in the first container.
  • the said support is driven in translational movement by both an element for detecting contact between a point of the end of the second tube and the level of the liquid sample, and by the means for detecting the passage of the sample in the second tube.
  • FIG. 1 is a schematic view of a preferred embodiment of the apparatus according to the invention.
  • FIG. 2 is a perspective view of the driving element of the apparatus shown in FIG. 1.
  • FIG. 3 is a diagram illustrating the control sequences in time of the element shown in FIG. 2.
  • FIG. I there is illustrated a first container in which is stored a sample which is to be transferred to a second container for the purpose of analysis.
  • the first container 1 is q bottle carrying in ascending order a sedimented sample phase 4, a liquid sample phase 3 to be analyzed and a portion 2 from which air has been partly evacuated.
  • This bottle is hermetically closed by two individual plugs 14 and sealing the enclosure. These plugs are made of a material which can be readily perforated by hollow needles or the like, and advantageously retractable.
  • the bottle is positioned below a neetile-carrying element 5 to which two needles 6 and 7 are fixed.
  • the first ends of the needles 6 and 7 are intended to pierce the plugs 14 and I5 and for this purpose are cut in bevelled form.
  • the portions of the two needles 6 and 7 which are intended to be positioned in the bottle 1 are of unequal length, the corresponding portion of the needle 6 being longer than the corresponding portion of the needle 7 by several millimeters, for example 2 to 3 millimeters.
  • the needle-carrying element 5 also supports an arm 8 comprising at its end, appropriately positioned, a photoelectric cell 9 excited respectively by light sources 22 arranged vertically at the other side along the bottle and represented diagrammatically.
  • the cell 9 is connected to a photoelectric detector 10.
  • the needle 6 is elbowed in such a manner that its second end is positioned in the second container or bottle forming chamber 18.
  • a detecting gauge 11 Situated in the circuit of the needle 6 between the bottle 1 and the chamber 18, at a distance corresponding to the calibrated volume to be transferred, is a detecting gauge 11, in this case advantageously a conductivity-measuring gauge.
  • This gauge is connected to a conductivity detector 12.
  • This gauge may also be of the photoelectic type.
  • the second end of the needle 7 is connected to a source of air or gas under pressure 19.
  • the detector circuits l2 and 13 are connected electrically to a control unit 16 of actuator 17.
  • the actuator l7 imparts a rectilinear sequential movement to the needle carrier 5.
  • the actuator 17 and the needle carrier 5 are in the upper position, the needles are also in the upper position and a bottle 1 is positioned mechanically below the needle carrier 5.
  • the actuator pushes the needles through the plugs 14 and 15 into the position illustrated in FIG. 1.
  • the needle 6 enters the limpid liquid and a fraction of a second afterwards the needle 7, in its turn, contacts the liquid.
  • the electrical resistance between the needles 6 and 7 which is considerable initially owing to the fact that all the parts in contact with the needles are of an insulating character has its resistance lowered and the detector circuit 13 trips, which sends an electrical signal into the control unit 16, which supplies a signal to the actuator to stop its downward travel.
  • the needles 6 and 7 stop with the needle 6 below the surface level of the liquid and the needle 7 just in contact with the surface.
  • the bevel of the needle 7 permits compressed air to enter the free portion 2 of the bottle without disturbing the surface of the liquid.
  • the actuator may comprise either a pneumatic jack operated by rapid-action electromagnetic valves, an electrohydraulic jack, or a step-by-step motor controlling a rack supporting the needle carrier 5 by means of a reduction gear, or any device for transmitting the aforesaid sequential movements.
  • the gear-rack system may advantageously be replaced by a known system of metal blades associated with a system of cylindrical drums, transforming a circular movement into an alternating rectilinear movement.
  • FIG. 2 shows one such embodiment.
  • a motor 23 which may be of a step-by-step type, drives a drum 25.
  • a drum 25 On this drum there are fixed one end of each flexible blade 26 and 27. The other end of each blade is fixed to a plate 24 which drives the needle carrier 5 and imparts the sequential movements to it.
  • the actuator is in the upper position indicated at the ordinate position P
  • the arrival of the control signal 21 triggers the sequence and the actuator descends.
  • the actuator is at position P, the needle 6 is immersed in the liquid phase 3 of the sample in the bottle 1 and the end of the needle 7 touches the surface of the liquid phase; the liquid can be delivered into the needle 6; the time interval AB corresponds to the descent of the needles into the bottle 1.
  • the actuator which had been in the position P up to this instant receives from the detector 12 a control signal to move upwards again; the time BC is the calibrating time.
  • the signal coming from the detector 13 is applied to the actuator which is positioned at P the ends of the needles 6 and 7 are still in the bottle 1 but are no longer in contact with the liquid phase 3 and the calibrated volume of the liquid inspired may be transferred into the chamber 18.
  • the time CD is the time corresponding to that in moving the needles upwards again out of the liquid.
  • the calibrated volume of liquid is entirely transferred into the chamber 18, and the actuator can again be returned to the upper position P,,.
  • the control signal for zeroizing 20 is applied and the actuator is maintained in the upper position i until a new identical sequence occurs.
  • the bottles such as the bottle 1 may constitute a continuous linear chain and be positioned automatically below the needle carrier 5.
  • the chambers such as the chamber 2, closed or otherwise, may be chambers comprised by a supporting film. This film may be driven in a step-by-step movement so that the chambers come successively to the position under the corresponding end of the needle 6, this end being also cut in bevelled form so as to pierce through the upper portion of the closed chamber.
  • the transfer device as described constitutes, therefore, an automatic pipette for transfer of liquid substances which can be provided for a continuous automatic sample-analyzing line.
  • the transfer of samples is effected rapidly and successively by means of the needle 6, the samples are forced in at one end and ejected at the other end, and the liquid passes through the needle, which has a smooth internal surface, by being pushed by a strong blast of air and entirely discharged.
  • the apparatus also permits transfer only of the liquid part of the samples with analysis effected solely on a calibrated volume of this liquid part.
  • the apparatus as claimed in claim 1 further comprising second means for detecting contact between the free end portion of the second tube and the surface level of said liquid sample, and means for further controlling translational movement of said support by said second detecting means.
  • said second detecting means comprises a conductivity-measuring device electrically connected between said first and second tubes.
  • said preventing means comprises a photoelectric detector and a light source arranged respectively on opposed sides of said first container, with said photoelectric detector being unenergized by the light source when it is adjacent the sedimented phase of the liquid sample to prevent further downward movement of said tubes with respect to said first container.
  • said actuator comprises a driven drum and at least two metal blades each having first ends fixed to the periphery of said drum and wrapped in opposite directions, and second ends fixed to said support for transforming circular movement into rectilinear movement.

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrology & Water Resources (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
US793498*A 1968-01-24 1969-01-23 Automatic transfer apparatus Expired - Lifetime US3596673A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR137316 1968-01-24

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US (1) US3596673A (pt)
JP (1) JPS4927067B1 (pt)
BE (1) BE726974A (pt)
CH (1) CH489002A (pt)
FR (1) FR1568072A (pt)
GB (1) GB1251435A (pt)
LU (1) LU57801A1 (pt)
NL (1) NL6901272A (pt)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812890A (en) * 1971-08-05 1974-05-28 Siemens Ag Device for transmitting predetermined volumes of liquid from one container to another container
US3848627A (en) * 1972-01-26 1974-11-19 L Page Apparatus for maintaining the water level within a swimming pool to predetermined limits
US3851181A (en) * 1973-11-07 1974-11-26 Audronics Inc Blood level detector
US3864577A (en) * 1972-11-07 1975-02-04 British Petroleum Co Tank filling monitor
US3894240A (en) * 1974-03-22 1975-07-08 Simer Pump Company Control circuit for maintaining a movable medium between limits
US4008048A (en) * 1973-07-06 1977-02-15 Agfa-Gevaert N.V. Installation for the discontinuous production of polyethylene terephthalate
US4082006A (en) * 1976-09-30 1978-04-04 Pitney-Bowes, Inc. Postage meter conversion apparatus
US4235829A (en) * 1979-05-07 1980-11-25 Western Electric Company, Inc. Vapor delivery system and method of maintaining a constant level of liquid therein
US4399711A (en) * 1980-04-18 1983-08-23 Beckman Instruments, Inc. Method and apparatus ensuring full volume pickup in an automated pipette
US4445238A (en) * 1982-09-29 1984-05-01 Maxhimer Monroe R Swimming pool water level control apparatus
US4662411A (en) * 1985-05-13 1987-05-05 General Mills, Inc. Assembly for liquid recovery from aseptically packaged beverage
US4873875A (en) * 1986-06-27 1989-10-17 Prism Technology, Inc. System for optically interrogating liquid samples and for withdrawing selected sample portions
US4888196A (en) * 1989-03-28 1989-12-19 The Procter & Gamble Company Process for tempering flavored confectionery compositions containing reduced calorie fats and resulting tempered products
US4912976A (en) * 1987-06-26 1990-04-03 Beckman Instruments, Inc. Liquid level sensing apparatus
AU620105B2 (en) * 1988-06-20 1992-02-13 Helena Laboratories Corporation Method and apparatus for discharging contents of sealed container
US5114033A (en) * 1989-07-21 1992-05-19 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US5178179A (en) * 1989-09-09 1993-01-12 Fresenius Ag Pressure equalizing vessel for a hemodialysis concentrate
US5211310A (en) * 1991-04-30 1993-05-18 Andronic Devices Ltd. Apparatus and method for dispensing phases of blood
US5308506A (en) * 1987-04-03 1994-05-03 Mcewen James A Apparatus and method for separating a sample of blood
US5400923A (en) * 1988-06-20 1995-03-28 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US5427136A (en) * 1991-11-27 1995-06-27 The Langston Corporation Fluid level detection system
US5555920A (en) * 1991-04-30 1996-09-17 Automed Corporation Method and apparatus for aliquotting blood serum or blood plasma
WO1998040159A2 (en) * 1997-03-10 1998-09-17 Trega Biosciences, Inc. Apparatus and method for combinatorial chemistry synthesis
US6302836B1 (en) * 1998-10-01 2001-10-16 Howard L. North, Jr. Method for partitioning blood and delivering clean serum
US20040123908A1 (en) * 2002-12-31 2004-07-01 Tiziani Peter C. Assembly for in-line valve actuation and indication
US20070169759A1 (en) * 2006-01-26 2007-07-26 Frenette Henry E Vapor fuel combustion system
US20070264602A1 (en) * 2006-01-26 2007-11-15 Frenette Henry E Vapor fuel combustion system
US20080202586A1 (en) * 2007-02-21 2008-08-28 Togare Radhakrishna Shesha Iye Automatic wireless liquid/water level controller
CN103611588A (zh) * 2013-12-16 2014-03-05 山东大学齐鲁医院 曲杆滑移式定位移液器
WO2015086066A1 (en) * 2013-12-11 2015-06-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Cell dispensing system
WO2016016109A3 (de) * 2014-07-29 2016-04-28 Joachim Gerstel Anordnung zur vorbereitung einer vielzahl von proben für ein analytisches verfahren
US9657938B2 (en) 2014-02-07 2017-05-23 Eugene R. Frenette Fuel combustion system
US9874349B2 (en) 2015-04-03 2018-01-23 Eugene R. Frenette Fuel combustion system

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DE2712208C2 (de) * 1977-03-19 1979-05-03 Walter Jansky Tank- & Apparatebau, 4407 Emsdetten Vorrichtung zum automatischen Abfüllen von Flüssigkeitsproben
US4387076A (en) * 1981-10-14 1983-06-07 Coulter Electronics, Inc. Sample feeding arrangement
EP0221315B1 (de) * 1985-10-09 1989-06-14 Kontron Instruments Holding N.V. Entnahmevorrichtung
LU87267A1 (de) * 1988-07-08 1990-02-07 Euratom Pneumatische vorrichtung zur automatischen entnahme einer fluessigkeitsprobe aus einem behaelter
GB2251690A (en) * 1990-11-05 1992-07-15 Rodney Whitham Optical liquid level detector

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US3235922A (en) * 1963-09-18 1966-02-22 Metal Pumping Services Inc Pump control system with timing means responsive to actual initial fluid delivery
US3367195A (en) * 1966-05-23 1968-02-06 William A. Racine Mechanical movement
US3388258A (en) * 1965-04-05 1968-06-11 Nasa Usa Fluid flow meter with comparator reference means
US3418061A (en) * 1963-12-30 1968-12-24 Dade Reagents Inc Flow cell construction with delivery and discharge means
US3438071A (en) * 1967-07-27 1969-04-15 Tee Pak Inc Dyeing of cellulose casing
US3459333A (en) * 1967-01-27 1969-08-05 Ici Ltd Liquid-dispensing apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3235922A (en) * 1963-09-18 1966-02-22 Metal Pumping Services Inc Pump control system with timing means responsive to actual initial fluid delivery
US3418061A (en) * 1963-12-30 1968-12-24 Dade Reagents Inc Flow cell construction with delivery and discharge means
US3388258A (en) * 1965-04-05 1968-06-11 Nasa Usa Fluid flow meter with comparator reference means
US3367195A (en) * 1966-05-23 1968-02-06 William A. Racine Mechanical movement
US3459333A (en) * 1967-01-27 1969-08-05 Ici Ltd Liquid-dispensing apparatus
US3438071A (en) * 1967-07-27 1969-04-15 Tee Pak Inc Dyeing of cellulose casing

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812890A (en) * 1971-08-05 1974-05-28 Siemens Ag Device for transmitting predetermined volumes of liquid from one container to another container
US3848627A (en) * 1972-01-26 1974-11-19 L Page Apparatus for maintaining the water level within a swimming pool to predetermined limits
US3864577A (en) * 1972-11-07 1975-02-04 British Petroleum Co Tank filling monitor
US4008048A (en) * 1973-07-06 1977-02-15 Agfa-Gevaert N.V. Installation for the discontinuous production of polyethylene terephthalate
US3851181A (en) * 1973-11-07 1974-11-26 Audronics Inc Blood level detector
US3894240A (en) * 1974-03-22 1975-07-08 Simer Pump Company Control circuit for maintaining a movable medium between limits
US4082006A (en) * 1976-09-30 1978-04-04 Pitney-Bowes, Inc. Postage meter conversion apparatus
US4235829A (en) * 1979-05-07 1980-11-25 Western Electric Company, Inc. Vapor delivery system and method of maintaining a constant level of liquid therein
US4399711A (en) * 1980-04-18 1983-08-23 Beckman Instruments, Inc. Method and apparatus ensuring full volume pickup in an automated pipette
US4445238A (en) * 1982-09-29 1984-05-01 Maxhimer Monroe R Swimming pool water level control apparatus
US4662411A (en) * 1985-05-13 1987-05-05 General Mills, Inc. Assembly for liquid recovery from aseptically packaged beverage
US4873875A (en) * 1986-06-27 1989-10-17 Prism Technology, Inc. System for optically interrogating liquid samples and for withdrawing selected sample portions
US5308506A (en) * 1987-04-03 1994-05-03 Mcewen James A Apparatus and method for separating a sample of blood
US4912976A (en) * 1987-06-26 1990-04-03 Beckman Instruments, Inc. Liquid level sensing apparatus
AU620105B2 (en) * 1988-06-20 1992-02-13 Helena Laboratories Corporation Method and apparatus for discharging contents of sealed container
US5400923A (en) * 1988-06-20 1995-03-28 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US4888196A (en) * 1989-03-28 1989-12-19 The Procter & Gamble Company Process for tempering flavored confectionery compositions containing reduced calorie fats and resulting tempered products
US5114033A (en) * 1989-07-21 1992-05-19 Helena Laboratories Corporation Apparatus for discharging contents of a sealed container
US5178179A (en) * 1989-09-09 1993-01-12 Fresenius Ag Pressure equalizing vessel for a hemodialysis concentrate
US5555920A (en) * 1991-04-30 1996-09-17 Automed Corporation Method and apparatus for aliquotting blood serum or blood plasma
US5413246A (en) * 1991-04-30 1995-05-09 Automed Corporation Apparatus and method for aliquotting phases of blood
US5211310A (en) * 1991-04-30 1993-05-18 Andronic Devices Ltd. Apparatus and method for dispensing phases of blood
US5427136A (en) * 1991-11-27 1995-06-27 The Langston Corporation Fluid level detection system
WO1998040159A2 (en) * 1997-03-10 1998-09-17 Trega Biosciences, Inc. Apparatus and method for combinatorial chemistry synthesis
WO1998040159A3 (en) * 1997-03-10 1999-01-07 Trega Biosciences Inc Apparatus and method for combinatorial chemistry synthesis
US6045755A (en) * 1997-03-10 2000-04-04 Trega Biosciences,, Inc. Apparatus and method for combinatorial chemistry synthesis
US6302836B1 (en) * 1998-10-01 2001-10-16 Howard L. North, Jr. Method for partitioning blood and delivering clean serum
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US9657938B2 (en) 2014-02-07 2017-05-23 Eugene R. Frenette Fuel combustion system
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CN106999955A (zh) * 2014-07-29 2017-08-01 约阿希姆·格斯特尔 用于准备大量用于分析方法的试样的组件
US10520519B2 (en) 2014-07-29 2019-12-31 Joachim Gerstel Arrangement for preparing a plurality of samples for an analytical method
CN112170024A (zh) * 2014-07-29 2021-01-05 约阿希姆·格斯特尔 用于准备大量用于分析方法的试样的组件
US11619643B2 (en) 2014-07-29 2023-04-04 Joachim Gerstel Arrangement for preparing a plurality of samples for an analytical method
EP4220180A3 (de) * 2014-07-29 2023-08-16 Joachim Gerstel Anordnung zur vorbereitung einer vielzahl von proben für ein analytisches verfahren
US11761971B2 (en) 2014-07-29 2023-09-19 Joachim Gerstel Arrangement for preparing a plurality of samples for an analytical method
US9874349B2 (en) 2015-04-03 2018-01-23 Eugene R. Frenette Fuel combustion system

Also Published As

Publication number Publication date
BE726974A (pt) 1969-07-16
LU57801A1 (pt) 1970-07-20
GB1251435A (pt) 1971-10-27
JPS4927067B1 (pt) 1974-07-15
FR1568072A (pt) 1969-05-23
CH489002A (fr) 1970-04-15
NL6901272A (pt) 1969-07-28

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