US3320952A - Nasal applicators - Google Patents

Nasal applicators Download PDF

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Publication number
US3320952A
US3320952A US410917A US41091764A US3320952A US 3320952 A US3320952 A US 3320952A US 410917 A US410917 A US 410917A US 41091764 A US41091764 A US 41091764A US 3320952 A US3320952 A US 3320952A
Authority
US
United States
Prior art keywords
tube
container
cap
pressurised container
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US410917A
Other languages
English (en)
Inventor
Wright Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Pharmaceuticals Ltd
Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Pharmaceuticals Ltd filed Critical Fisons Pharmaceuticals Ltd
Application granted granted Critical
Publication of US3320952A publication Critical patent/US3320952A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container
    • B65D83/386—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container actuation occurring by moving the aerosol container relative to the outer shell or external container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant

Definitions

  • medicaments intended for nasal application are often of the decongestant type intended to relieve congestion in the upper part of the nose and in the sinuses.
  • Other drugs which may be applied by nasal inhalation are those intended to relieve inflammation in the upper nose and in the sinuses.
  • Drugs for systemic action can also be administered by this route.
  • Such medicaments are normally applied in liquid form by means of a short rigid tube of glass or other thermoplastic material which is inserted into the nostril, the medicament being forced through the tube by the action of a compressible rubber bulb or like means.
  • Such devices are, in general, inefiicient in supplying the medicament in uniform dosages and are, therefore, not suitable for the clinical application of medicaments by nasal inhalation. Further, such devices generally supply the liquid in the form of thin stream or as a stream of relatively large droplets with consequent inefficiency in absorption.
  • pressurised packs i.e., by dispersing the medicament in a propellant in a pressurised container, the pressurised container preferably being fitted with a valve of such a type as to deliver a metered dose of the medicament.
  • pressurised packs are fitted with a rigid tube for insertion into the nostril as described above.
  • inhaling medicaments with this form of applicator it is difiicult to obtain suitable dispersion of the medicament in air as no air is inhaled therewith.
  • dangers may arise from the discharge of a close of medicament into a nostril blocked at its upper end with mucus and its lower end with the applicator, as the expanding dose of medicament may damage the membrane. It is an object of the present invention to provide an improved nasal applicator for applying a medicament contained in a pressurised container.
  • an improved nasal applicator for the application of a medicament contained in a pressurised container which comprises a rigid tube having mounted in the lower part thereof and co-axial therewith a spray button adapted to engage with the stem of a pressurised container and to spray the medicament along the length of the rigid tube, said spray button being mounted in said rigid tube by struts or supports so as to provide air passages between the outside of said button and the inside of said rigid tube.
  • the lower end of the rigid tube connects with or forms part of a hollow frusto-conical member which in turn connects with or forms part of a skirt adapted to surround the upper portion of the pressurised container.
  • the skirt extends to form a cylindrical casing enclosing the pressurised container; the casing having an opening in the lower end wall thereof to enable the container to be urged towards the spray button, to actuate the container valve, by finger pressure.
  • a bush-button may be provided operating through an opening in the lower end wall to urge the container towards the spray button.
  • the cylindrical casing or part thereof may be a separate moulding secured to the skirt by any desired means, e.g., welding, glueing, or, preferably, by a clip fit.
  • the device is preferably fitted with a removeable cap fitting over the spray tube.
  • This cap may 'be a simple friction fitting cap fitting over the spray tube or may be more elaborate.
  • an improved form of cap for the applicator has lugs depending from the lower portion thereof which lugs rest upon the shoulders of the pressurised container to prevent accidental discharge of the container. Where the applicator has a lower frustoconical portion, the lugs pass through slots therein and may engage therewith in a bayonet cap action to lock the cap.
  • the applicator and cap are conveniently made of thermoplastic material such as nylon and may be made by injection or other form of moulding.
  • the applicator is conveniently designed to be used in conjunction with pressurised containers having a nominal capacity of, for example, about 10 cc.
  • the pressurised container is one having a metering valve, i.e. a valve delivering a metered dose on actuation; a wide variety of such valves being known.
  • FIGURE 1 is a vertical cross-section through one preferred applicator according to the invention.
  • FIGURE 2 is a view at the line AA in FIGURE 1;
  • FIGURE 3 shows the applicator shown in FIGURE 1 in position on a pressurised container
  • FIGURE 4 is similar to FIGURE 3 and shows the preferred form of cap in position
  • FIGURE 5 is a vertical cross-section through another preferred form of assembly with bayonet locking cap.
  • FIGURE 6 is a vertical cross-section through a device similar to that shown in FIGURE 5 but having a simple friction fitting cap.
  • an applicator comprises a delivery tube 1 having a shoulder portion 2 and a skirt portion 3.
  • spray button 4 mounted within tube 1 by means of ribs 5 is spray button 4 which has a stern receiving chamber 6, a spray chamber 7 and spray hole 8.
  • shoulder portion 2 of the applicator is provided with slots 9 to permit passage of lugs 11 of a cap 10 as shown in FIGURES 4 and 5.
  • FIGURE 3 shows the applicator in position on a pressurised container with chamber 6 surrounding the top of stem 13 of valve 12 of pressurised container 14.
  • depression of the complete applicator mechanism operates valve 12 and the pressurized medicament is expelled via chamber 7 and hole 8 through tube 1 to be inhaled together with air passing between ribs 5.
  • FIGURES 4 and 5 show cap 10 in position with lugs 11 passing through slots 9 to engage on container 14 to prevent accidental discharge of the device.
  • lugs 11 co-act with slots 9 so as to lock the cap in position by a bayonet cap action.
  • cylindrical casing 15 clip fits onto the outside of skirt 3 and encloses container 14.
  • Through opening 17 in the lower end wall 16 of casing 15 passes push-button 18 which serves to actuate the dispenser.
  • opening 17 is left open and is wide enough to admit a finger to actuate the device.
  • container 14 may be spaced from the inside of casing 15 by longitudinal ribs.
  • cap 10 is a close friction fit to delivery tube 1.
  • push-button 18 is pressed to urge container 14 towards spray button .4 to actuate valve 12.
  • a nasal applicator for the application of a medicament contained in a pressurised container having a stem for dispensing the medicament, which comprises a pressurised container, a rigid tube the lower end of which has a hollow frusto-conical member thereon, a skirt on the lower end of said frusto-conical member and surrounding the upper portion of the pressurised container, said rigid tube having mounted in the lower part thereof and coaxial therewith a spray button engaging with the stem of the pressurised container and adapted to spray the medicament along the length of the tube, struts mounting said spray button in said rigid tube so as to provide air passages between the outside of said button and the inside of said rigid tube, a cap having slotted lugs dependent from the lower portion thereof and passing through slots in said hollow frusto-conical member and resting on the pressurised container, said slotted lugs locking the cap in position andpreventing relative movement between said pressurised container and said hollow frusto-conical member in the direction of movement of said tube toward and away from
  • a nasal applicator as claimed in claim 1 in which said slotted lugs each have a lateral extension on the end thereof coacting with said struts to lock said cap in position by a bayonet type action.
  • a nasal applicator for the application of a medicament contained in a pressurised container having a stem for dispensing the medicament, which comprises a pressurised container, a rigid tube the lower end of which has a hollow frusto-conical member thereon, a cylindrical casing adapted to enclose a pressurised container and having an opening in the lower end wall thereof, a pushbutton extending through said opening in the lower end wall of said cylindrical casing, said rigid tube having mounted in the lower part thereof and coaxial therewith a spray button engaging with the stern of the pressurised container and adapted to spray the medicament along the length of the tube, struts mounting said spray button in said rigid tube so as to provide air passages between the outside of said button and the inside of said rigid tube, a cap having slotted lugs dependent from the lower portion thereof and passing through slots in said hollow frusto-conical member and resting on the pressurised container, said slotted lugs locking the cap in position and preventing relative movement between said pressurised container and

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Closures For Containers (AREA)
US410917A 1963-11-22 1964-11-13 Nasal applicators Expired - Lifetime US3320952A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB46123/63A GB1085060A (en) 1963-11-22 1963-11-22 Nasal applicators for use with pressurised dispensing containers

Publications (1)

Publication Number Publication Date
US3320952A true US3320952A (en) 1967-05-23

Family

ID=10439932

Family Applications (1)

Application Number Title Priority Date Filing Date
US410917A Expired - Lifetime US3320952A (en) 1963-11-22 1964-11-13 Nasal applicators

Country Status (9)

Country Link
US (1) US3320952A (it)
BE (1) BE656080A (it)
CH (1) CH420495A (it)
DE (1) DE1491707C3 (it)
DK (1) DK116021B (it)
FR (1) FR1452612A (it)
GB (1) GB1085060A (it)
NL (1) NL6413357A (it)
SE (1) SE332875B (it)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3698390A (en) * 1969-10-27 1972-10-17 Frank Donald Ferris Dispensing for medicaments
US5012804A (en) * 1989-03-06 1991-05-07 Trudell Medical Medication inhaler with adult mask
US5012803A (en) * 1989-03-06 1991-05-07 Trudell Medical Modular medication inhaler
US5074871A (en) * 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5156610A (en) * 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5160342A (en) * 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
US5211651A (en) * 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5282484A (en) * 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5643298A (en) * 1992-11-09 1997-07-01 Nordgren; Gregory N. Intra-artery obstruction clearing apparatus and methods
US5665098A (en) * 1992-11-09 1997-09-09 Endovascular Instruments, Inc. Unitary removal of plaque
US6165187A (en) * 1989-08-18 2000-12-26 Endo Vascular Instruments, Inc. Method of enlarging a lumen of an artery
US6581590B1 (en) * 2000-03-21 2003-06-24 Iep Pharmaceutical Devices Inc. Inhalation actuated device
US20120017902A1 (en) * 2008-11-03 2012-01-26 Schering Corporation Elastomeric discharge member for nasal delivery device
US10335563B2 (en) 2013-05-14 2019-07-02 3M Innovative Properties Company Actuator for an inhaler
US20220401663A1 (en) * 2021-06-18 2022-12-22 Loop Laboratories, LLC Compact atomizer
US20240252485A1 (en) * 2019-07-09 2024-08-01 Orexo Ab Pharmaceutical composition for nasal delivery

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504097A1 (fr) * 1981-04-16 1982-10-22 Aerosols Ste Mediterraneenne Bombe aerosol de defense
US4944429A (en) * 1987-08-28 1990-07-31 Schering Corporation Manually-operable spray dispenser with locking mechanism
FR2626254B1 (fr) * 1988-01-27 1990-07-06 Valois Sa Poussoir-etui avec systeme de garantie
FR2657795B1 (fr) * 1990-02-05 1992-05-07 Fouche Bernard Dispositif mecanique commande par un allumeur pyro-electrique pour diffuser un produit contenu dans un aerosol.
DE9102463U1 (de) * 1991-03-01 1992-06-25 Perfect-Valois Ventil GmbH, 4600 Dortmund Sprühflasche
GB9814305D0 (en) * 1998-07-01 1998-09-02 Chown Peter A C Apparatus for operating a pressurised container
GB0518770D0 (en) * 2005-09-14 2005-10-26 Glaxo Group Ltd A closure for a dispensing device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2998822A (en) * 1959-06-12 1961-09-05 Herbert M Birch Self-contained push button applicator
US3001524A (en) * 1956-03-21 1961-09-26 Riker Laboratories Inc Aerosol dispensing apparatus
US3012555A (en) * 1959-05-18 1961-12-12 Meshberg Philip Dispensing package for material under pressure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3001524A (en) * 1956-03-21 1961-09-26 Riker Laboratories Inc Aerosol dispensing apparatus
US3012555A (en) * 1959-05-18 1961-12-12 Meshberg Philip Dispensing package for material under pressure
US2998822A (en) * 1959-06-12 1961-09-05 Herbert M Birch Self-contained push button applicator

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3698390A (en) * 1969-10-27 1972-10-17 Frank Donald Ferris Dispensing for medicaments
US5012804A (en) * 1989-03-06 1991-05-07 Trudell Medical Medication inhaler with adult mask
US5012803A (en) * 1989-03-06 1991-05-07 Trudell Medical Modular medication inhaler
US6165187A (en) * 1989-08-18 2000-12-26 Endo Vascular Instruments, Inc. Method of enlarging a lumen of an artery
US5156610A (en) * 1989-08-18 1992-10-20 Evi Corporation Catheter atherotome
US5211651A (en) * 1989-08-18 1993-05-18 Evi Corporation Catheter atherotome
US5282484A (en) * 1989-08-18 1994-02-01 Endovascular Instruments, Inc. Method for performing a partial atherectomy
US5074871A (en) * 1989-12-07 1991-12-24 Evi Corporation Catheter atherotome
US5160342A (en) * 1990-08-16 1992-11-03 Evi Corp. Endovascular filter and method for use thereof
US5435297A (en) * 1991-08-29 1995-07-25 Christoph Klein Medical device for inhaling metered aerosols
US5643297A (en) * 1992-11-09 1997-07-01 Endovascular Instruments, Inc. Intra-artery obstruction clearing apparatus and methods
US5665098A (en) * 1992-11-09 1997-09-09 Endovascular Instruments, Inc. Unitary removal of plaque
US5746758A (en) * 1992-11-09 1998-05-05 Evi Corporation Intra-artery obstruction clearing apparatus and methods
US5643298A (en) * 1992-11-09 1997-07-01 Nordgren; Gregory N. Intra-artery obstruction clearing apparatus and methods
US6581590B1 (en) * 2000-03-21 2003-06-24 Iep Pharmaceutical Devices Inc. Inhalation actuated device
US20120017902A1 (en) * 2008-11-03 2012-01-26 Schering Corporation Elastomeric discharge member for nasal delivery device
US10335563B2 (en) 2013-05-14 2019-07-02 3M Innovative Properties Company Actuator for an inhaler
US20240252485A1 (en) * 2019-07-09 2024-08-01 Orexo Ab Pharmaceutical composition for nasal delivery
US20220401663A1 (en) * 2021-06-18 2022-12-22 Loop Laboratories, LLC Compact atomizer

Also Published As

Publication number Publication date
DK116021B (da) 1969-12-01
DE1491707B2 (de) 1973-07-26
DE1491707A1 (de) 1969-03-06
BE656080A (it) 1965-05-20
DE1491707C3 (de) 1974-02-21
FR1452612A (fr) 1966-09-16
CH420495A (fr) 1966-09-15
NL6413357A (it) 1965-05-24
SE332875B (it) 1971-02-22
GB1085060A (en) 1967-09-27

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