US3288795A - 1, 4-bis-(diphenylacetyl) piperazines - Google Patents

1, 4-bis-(diphenylacetyl) piperazines Download PDF

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Publication number
US3288795A
US3288795A US476230A US47623065A US3288795A US 3288795 A US3288795 A US 3288795A US 476230 A US476230 A US 476230A US 47623065 A US47623065 A US 47623065A US 3288795 A US3288795 A US 3288795A
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US
United States
Prior art keywords
bis
piperazine
diphenylacetyl
piperazines
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US476230A
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English (en)
Inventor
Irikura Tsutomu
Masuzawa Kuniyasu
Nishino Keigo
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Individual
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Individual
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Publication date
Application filed by Individual filed Critical Individual
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Publication of US3288795A publication Critical patent/US3288795A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US476230A 1964-07-31 1965-07-29 1, 4-bis-(diphenylacetyl) piperazines Expired - Lifetime US3288795A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4370264 1964-07-31

Publications (1)

Publication Number Publication Date
US3288795A true US3288795A (en) 1966-11-29

Family

ID=12671133

Family Applications (1)

Application Number Title Priority Date Filing Date
US476230A Expired - Lifetime US3288795A (en) 1964-07-31 1965-07-29 1, 4-bis-(diphenylacetyl) piperazines

Country Status (6)

Country Link
US (1) US3288795A (enrdf_load_stackoverflow)
BE (1) BE666989A (enrdf_load_stackoverflow)
CH (1) CH460020A (enrdf_load_stackoverflow)
DE (1) DE1570037A1 (enrdf_load_stackoverflow)
FR (1) FR5036M (enrdf_load_stackoverflow)
GB (1) GB1051527A (enrdf_load_stackoverflow)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008324A (en) * 1975-01-23 1977-02-15 Ludwig Merckle Kg Phenoxyalkylcarboxylic acid salt of 1-cinnamyl-4-diphenylmethyl piperazine, method of preparation and antihypercholesteremic
US5292726A (en) * 1991-05-22 1994-03-08 Merck & Co., Inc. N,N-diacylpiperazines
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) * 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
WO2000001375A3 (en) * 1998-06-30 2000-08-31 Neuromed Tech Inc Calcium channel blockers
US6310059B1 (en) 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US20040034035A1 (en) * 1998-06-30 2004-02-19 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040044004A1 (en) * 1998-06-30 2004-03-04 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040147529A1 (en) * 1998-06-30 2004-07-29 Snutch Terrance P. Preferentially substituted calcium channel blockers
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US20090312346A1 (en) * 2006-05-11 2009-12-17 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3917601A1 (de) * 1989-05-31 1990-12-06 Basf Ag Verdoppelte triphenylmethanfarbstoffe sowie piperazinderivate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4008324A (en) * 1975-01-23 1977-02-15 Ludwig Merckle Kg Phenoxyalkylcarboxylic acid salt of 1-cinnamyl-4-diphenylmethyl piperazine, method of preparation and antihypercholesteremic
US5292726A (en) * 1991-05-22 1994-03-08 Merck & Co., Inc. N,N-diacylpiperazines
US5344830A (en) * 1992-12-10 1994-09-06 Merck & Co., Inc. N,N-diacylpiperazine tachykinin antagonists
US5348955A (en) * 1993-06-22 1994-09-20 Merck & Co., Inc. N,N-diacylpiperazines
EP1466605A3 (en) * 1998-06-30 2004-11-17 Neuromed Technologies Inc. Calcium channel blockers
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
US6310059B1 (en) 1998-06-30 2001-10-30 Neuromed Technologies, Inc. Fused ring calcium channel blockers
US6387897B1 (en) 1998-06-30 2002-05-14 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
JP2002519372A (ja) * 1998-06-30 2002-07-02 ニューロメド テクノロジーズ， インコーポレイテッド カルシウムチャネル遮断薬
US6492375B2 (en) 1998-06-30 2002-12-10 Neuromed Technologies, Inc. Partially saturated calcium channel blockers
US6617322B2 (en) 1998-06-30 2003-09-09 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US20040034035A1 (en) * 1998-06-30 2004-02-19 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040044004A1 (en) * 1998-06-30 2004-03-04 Neuromed Technologies, Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US20040147529A1 (en) * 1998-06-30 2004-07-29 Snutch Terrance P. Preferentially substituted calcium channel blockers
US20040192703A1 (en) * 1998-06-30 2004-09-30 Snutch Terrance P. Preferentially substituted calcium channel blockers
US20040209872A1 (en) * 1998-06-30 2004-10-21 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
WO2000001375A3 (en) * 1998-06-30 2000-08-31 Neuromed Tech Inc Calcium channel blockers
US6294533B1 (en) 1998-06-30 2001-09-25 Neuormed Technologies, Inc. Calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6943168B2 (en) 1998-06-30 2005-09-13 Neuromed Technologies Inc. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6949554B2 (en) 1998-06-30 2005-09-27 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US6951862B2 (en) 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US7666865B2 (en) 1998-06-30 2010-02-23 Neuromed Pharmaceuticals Ltd. Calcium channel blockers
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US7064128B2 (en) 1998-06-30 2006-06-20 Neuromed Technologies, Inc. Preferentially substituted calcium channel blockers
US7186726B2 (en) 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US20070185105A1 (en) * 1998-06-30 2007-08-09 Snutch Terrance P Calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
US20090312346A1 (en) * 2006-05-11 2009-12-17 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8362021B2 (en) 2006-05-11 2013-01-29 Zalicus Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8591944B2 (en) 2011-03-08 2013-11-26 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof

Also Published As

Publication number Publication date
GB1051527A (enrdf_load_stackoverflow)
FR5036M (enrdf_load_stackoverflow) 1967-05-02
CH460020A (de) 1968-07-31
BE666989A (enrdf_load_stackoverflow) 1965-11-16
DE1570037A1 (de) 1970-02-05

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