US3261837A - Process for the production of quinacridine diones - Google Patents
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- US3261837A US3261837A US279337A US27933763A US3261837A US 3261837 A US3261837 A US 3261837A US 279337 A US279337 A US 279337A US 27933763 A US27933763 A US 27933763A US 3261837 A US3261837 A US 3261837A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B48/00—Quinacridones
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41C—PROCESSES FOR THE MANUFACTURE OR REPRODUCTION OF PRINTING SURFACES
- B41C1/00—Forme preparation
- B41C1/055—Thermographic processes for producing printing formes, e.g. with a thermal print head
Definitions
- quinacridones are known compounds which are suitable in finely divided form for the pigmentation of lacquer media and plastics.
- linear quinacridones can be produced by condensation of bis-(arylam-ino)- benzenedicarboxylic acids or the esters of these acids.
- An example is the production of quinacridine-7,14-diones according to the following formula:
- a and B represent the atoms necessary for the completion of an aromatic isocyclic or heterocyolic radical. These radicals may be identical or different. They are preferably phenylene radicals or radicals of condensed ring systems consisting entirely of 6 rings or of 6 and 5 rings which may be substituted. Suitable radicals Of this type are, for example, those of naphthalene, anthraquinone, pyrene and carbazol. The ubstituents on the rings containing A and B may be e.g.
- halogen atoms or nitro, cyan :or amino groups or any of the following groups which may be further substituted: alkyl, 'alkoxy, aryl, aryloxy, azoaryl, alkylamino, arylamino, alkylsulphonyl, arylsulphonyl, acyl, acylamino, carboxylic acid or sulphonic acid ester groups, or other, preferably non'ionic and non-water-solubilising substituents.
- the radicals containing A and B may bear identical or different substituents.
- the quinacridone molecule may be asymmetrical even when the rings containing A and B are identical.
- the condensation can be carried out with the aid of zinc chloride, benzoyl chloride, aqueous hydrobromic acid, hydrogen bromide in glacial acetic acid, phosphorus pentoxide in tetrahydronaphthalene or cymene, phosphorus pentachloride together with aluminium chloride in benzene, or with boric acid in the melt.
- hydrofluoric acid, phthalic anhydride, or metal halides are used, the condensation being performed in the melt or in the presence of an indilferent organic 3,261,837 Patented July 19, 19 66 solvent.
- sulphuric acid or its derivatives have been used as condensing agents. These methods yield sulphonated quinacridones from which the sulphonic acid groups must be split off under pressure.
- quinacridones from bis-(arylamino)-benzenedicarboxylic acids or their esters more particularly from 2,5-diarylaminoterephthalic acids or their esters with the aid of phosphorus halides in particular phosphorus oxychloride as condensing agents and in the presence of an organic solvent for the condensing agent used.
- the solvent does not take part in the reaction, ie it is indifferent.
- the condensation products are obtained in good yield and purity and have low grain hardness and high brilliance of shade without aftertreatment.
- This process is particularly well suited for the production of compounds of Formula II and primarily for those compounds of that formula in which A and B represent the atoms necessary for the completion of a benzene ring which may be unsubstituted or substituted so that the molecule of the quinacridone obtained contains 1 or 2 nitro groups, 1 to 4 and especially 1 or 2 lower alkyl groups each with 1 to 4 C atoms, 1 to 4 and especially 1 or 2 lower alkoxy groups each with l to 4 C atoms, 1 or 2 cyan groups, 1 or 2 methylsulfionyl groups, or 1 to 4 halogen atoms, more particularly chlorine or bromine atoms.
- the quinacridone molecule when not unsubstituted, contains preferably 1 to 4 identical or different substituents of the aforenamed types.
- phosphorus oxychloride In addition to phosphorus oxychloride, phosphorus oxybromide, phosphorus triand pentachloride, phosphorus triand penta-bromide, and mixtures of these phosphorus halides can be used as condensing agents.
- the best solvents are those which have good dissolving action on the condensing agent used at the temperature of condensation and whose boiling points are between and 300 C., preferably within the range -270 C.
- solvents that are particularly suitable are aromatic hydrocarbons, e.g. diplrenyl, hydrogenated aromates, e.g. tetrahydronaphthalene and hexahydronaphthalene, halogenated aromates, e.g.
- dichlorobenzenes and trichlorobenzenes l-chloronaphthalene and 2-chloronaphthalene
- ralkylated aromates e.g. l-methylnaphthalene and Z-ethylnapht-halene
- nitrated aromates e.g. nitrob-enzene, p-nitro-diphenyl
- solvents for example o-nitrodiphenyl and l-nitronaphthalene, diphenyl ether, diphenyl oxide, chloronitrobenzene, the eutectic mixture of diphenyl and diphenyl oxide or other mixtures of the solvents named supra.
- the most preferred groups of solvents are the hydrocarbons, the halogenated hydrocarbons and the nitrated hydrocarbons.
- the most favourable procedure is to heat the starting acid, for instance 2,5-bis-(arylamino)-terephthalic acid, and the solvent to about 75 to 350 C., or preferably 150 to 270 C., and to add at this temperature the phosphorus halide, if necessary dissolved in a small amount of solvent, and to stir the mass for some time a'bout 15 minutes to 5 hours depending on the starting materialat the same high temperature.
- the reaction product is then precipitated. It can be Worked up as desired, e.g. diluted with a solvent such as metha nol, filtered off, washed with solvent and possibly with dilute ammonia to remove any residual acid, and then dried.
- the compounds obtained are brilliant pigments insoluble in standard solvents. Being soft grained, they are particularly well suited for the pigmentation of lacquer media, printing inks and plastics in the mass.
- the pigmentations have good colour fastness properties, notably good fastness to light, heat and solvents, and do not show bleeding.
- the phosphorus oxychloride can be replaced by 20.9 parts of phosphorus tribromide or by 14 parts of phosphorus pentabromide.
- solvents besides methanol can be used for dilution, e.g. ethanol, dimethyl formamide, dimethyl sulphoxide, dimethyl acetamide, N-methylformamide and pyridine.
- EXAMPLE 2 A mixture of 5.9 parts of phosphorus oxychloride and 73.5 parts of trichlorobenzene is added to a mixture of parts of 2-phenylamino-5-(4-methylphenylamino)- terephthalic acid and 735 parts of trichlorobenzene at 215 in 30 minutes with constant stirring. After stirring for a further 30 minutes at this temperature the mass is allowed to cool to 95 parts of water are added, and it is then stirred for 15 minutes at 95 100 and subsequently diluted with 700 parts of methanol at 80. The precipitate is filtered off at room temperature, washed successively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum. The product is 17.9 parts of 2-methylquinacridone-7,14-dione. The yield is 99.5 of theory.
- the phosphorus oxychloride can be replaced by 10.6 parts of phosphorus trichloride or 4.6 parts of phosphorus pentachloride, and the 20 parts of 2-phenylamino-5-(4'- methylphenylamino)-terephthalic acid can be replaced by 20 parts of 2,5-di-(4'-methylphenylamino)-terephthalic acid, the procedure being otherwise the same as above.
- the solvent trichlorobenzene can be replaced by the same amount of one of the following: nitrobenzene, 1- or 2-chloronaphthalene, l-methylnaphthalene, 2-ethylnaphthalene, hexahydronaphthalene, or tetrahydronaph thalene, and the reaction can be effected at temperatures up to the boiling point of these solvents.
- the quinacridones obtained in this way can be used immediately for the pigmentation of lacquer media, printing inks or plastics, e.g. polyvinyl chloride, polyolefins and polystyrene. If desired, they can be purified, e.g. by precipitation from solution in 70-85% sulphuric acid.
- EXAMPLE 3 7.6 parts of phosphorus oxychloride are added to a mixture of 20 parts of 2-phenylamino-5-(4'-methylphenylamino)-terephthalic acid and 440 parts of trichlorobenzene at 25.
- the reaction mixture is constantly stirred and its temperature continuously increased as follows: from 25 to in 3 hours, from 75 to in 6 hours, from 100 to in 14 hours, from 110 to 185 in 4 hours, and from 185 to 200 in 4 /2 hours. It is then cooled to 95 and 25 parts of water are added. After stirring for 15 minutes at 95100 the product is isolated and worked up as described in Example 1, with vacuum drying at 60. 17.3 parts of 2-methylquinacridine-7,14-dione are obtained. The yield is 96% of theory.
- the 20 parts of 2,5-di-(3'-chlorophenylamino)-terephthalic acid can be replaced by 20 parts of 2,5-di-(2'- chlorophenylamino)-terephthalic acid or by 20 parts of 2,5-di-(4'-chlorophenylamino)-terephthalic acid.
- quinacridine-7, 14-diones which are obtainable according to the procedures detailed in the foregoing examples. They are formed by ring closure of a 2,5-diarylaminoterephthalic acid of the formula nooo- NH-A which can also be employed in the form of its esters, preferably its low molecular alkyl esters, having from 1 to about 4 carbon atoms in the alcohol radical, e.g. its
- EXAMPLE 30 A mixture of 5.9 parts of phosphorus oxychloride and 73.5 parts of trichlorobenzene is added in 30 minutes with stirring to a mixture of parts of 2-phenylamino- 5-(4-chlorophenylamino)-terephthalic acid and 735 parts of trichlorobenzene at 215. Stirring is continued for a further minutes at this temperature. The obtained precipitate is filtered oil at room temperature, washed successively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum. 17 parts of 2-chloroquinacridine-7,14-dione are obtained.
- the 20 parts of 2-phenylamino-5-(4-chlorophenylamino)-terephthali-c acid can be replaced by 20 parts of 2-phenylamino-5- (2-chlorophenylamino -terephthalic acid or 2-phenylamino-5-(3-chlorophenylamino)-terephthalic acid and the process performed under the same conditions as above.
- each of A and B represents the atoms necessary for the completion of a cyclic radical selected from the class consisting of unsubstituted phenyl, phenyl substituted by 1 lower alkyl group, phenyl substituted by 1 nitro group, phenyl substituted by 1 lower alkoxy group, phenyl substituted by 1 cyan group, phenyl substituted by 1 methylsulfonyl group, phenyl substituted by 1 to 3 halogen atoms, naphthyl, pyrenyl and car-bazyl, the acid of Formula I containing no more than 4 substituents in phenylamino radicals,
- an organic solvent for the phos phorus halide which is selected from the class consisting of hydrocarbons, halogenated hydrocarbons and nitrated hydrocarbons with boiling points between and 300 C.
- each of A and B represents the atoms necessary for the completion of a cyclic radical selected from the class consisting of unsubstituted phenyl, phenyl substituted by 1 lower alkyl group, phenyl substituted by 1 nitro group, phenyl substituted by 1 lower alkoXy group, phenyl substituted by 1 cyan group, phenyl substituted by 1 methylsultfonyl group, phenyl substituted by 1 to 3 halogen atoms, naphthyl, pyrenyl and carbazyl, the acid of Formula I containing no more than 4 substituents in phenylamino radicals, in the presence of from 0.5 to 1.5 moles of phosphorus oxychloride with reference to 1 mole of the acid of Formula I and in the presence of an organic solvent for the phosphorus halide which is selected from the class consisting of hydrocarbons, halogenated hydrocarhons and nitrated hydrocarbons with boiling points between 150
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Description
United States Patent 3,261,837 PRGCESS FOR THE PRUDUCTHON 0F QUINACRIDINE DIONES Hans Bohler, Basel, Switzerland, assignor to Sandoz Ltd. (also known as Sandoz A.G.), Basel, Switzerland No Drawing. Filed May 9, 1963, Ser. No. 279,337 Claims priority, application Switzerland, May 15, 1962,
5,892/62; July 31, 1962, 9,144/62 and 9,145/62; Apr.
5 Claims. (Cl. 260-479) Quinacridine diones, termed hereunder quinacridones, are known compounds which are suitable in finely divided form for the pigmentation of lacquer media and plastics. Several methods are known whereby linear quinacridones can be produced by condensation of bis-(arylam-ino)- benzenedicarboxylic acids or the esters of these acids. An example is the production of quinacridine-7,14-diones according to the following formula:
In Formula II A and B represent the atoms necessary for the completion of an aromatic isocyclic or heterocyolic radical. These radicals may be identical or different. They are preferably phenylene radicals or radicals of condensed ring systems consisting entirely of 6 rings or of 6 and 5 rings which may be substituted. Suitable radicals Of this type are, for example, those of naphthalene, anthraquinone, pyrene and carbazol. The ubstituents on the rings containing A and B may be e.g. halogen atoms or nitro, cyan :or amino groups, or any of the following groups which may be further substituted: alkyl, 'alkoxy, aryl, aryloxy, azoaryl, alkylamino, arylamino, alkylsulphonyl, arylsulphonyl, acyl, acylamino, carboxylic acid or sulphonic acid ester groups, or other, preferably non'ionic and non-water-solubilising substituents. The radicals containing A and B may bear identical or different substituents.
Consequently the quinacridone molecule may be asymmetrical even when the rings containing A and B are identical.
According to H. Liebermann (Liebigs Annalen der Chemie 518, p. 246) the condensation can be carried out with the aid of zinc chloride, benzoyl chloride, aqueous hydrobromic acid, hydrogen bromide in glacial acetic acid, phosphorus pentoxide in tetrahydronaphthalene or cymene, phosphorus pentachloride together with aluminium chloride in benzene, or with boric acid in the melt. In other methods hydrofluoric acid, phthalic anhydride, or metal halides are used, the condensation being performed in the melt or in the presence of an indilferent organic 3,261,837 Patented July 19, 19 66 solvent. Further, sulphuric acid or its derivatives have been used as condensing agents. These methods yield sulphonated quinacridones from which the sulphonic acid groups must be split off under pressure.
In these known methods the quinacridones are obtained in unsatisfactory yield, and in part the methods are technically difficult.
Good yields are obtained when the condensation is effected with the aid of polyphosphoric acid in the melt, but unless the condensation products are aitertreated they do not have the high brilliance and the low grain hardness that are required of pigments.
Further, it is known (N. Anitschkoff, Berlin University thesis, 1934) that the action of phosphorus oxychloride upon 2,5-bis-(phenylamino)-terephthalic acid or its derivatives that are ubstituted in the terminal nuclei in the absence of solvents or diluents gives rise to products of different constitution whose solutions in alcoholic potas sium hydroxide solution are not blue like those of quinacridones but emerald-green.
It has now been [found that it is especially advantageous to produce quinacridones from bis-(arylamino)-benzenedicarboxylic acids or their esters more particularly from 2,5-diarylaminoterephthalic acids or their esters with the aid of phosphorus halides in particular phosphorus oxychloride as condensing agents and in the presence of an organic solvent for the condensing agent used. The solvent does not take part in the reaction, ie it is indifferent.
The condensation products are obtained in good yield and purity and have low grain hardness and high brilliance of shade without aftertreatment. This process is particularly well suited for the production of compounds of Formula II and primarily for those compounds of that formula in which A and B represent the atoms necessary for the completion of a benzene ring which may be unsubstituted or substituted so that the molecule of the quinacridone obtained contains 1 or 2 nitro groups, 1 to 4 and especially 1 or 2 lower alkyl groups each with 1 to 4 C atoms, 1 to 4 and especially 1 or 2 lower alkoxy groups each with l to 4 C atoms, 1 or 2 cyan groups, 1 or 2 methylsulfionyl groups, or 1 to 4 halogen atoms, more particularly chlorine or bromine atoms. The quinacridone molecule, when not unsubstituted, contains preferably 1 to 4 identical or different substituents of the aforenamed types.
In general not less than 0.4 mole and not more than appnoximately 3 moles of the phosphorus halide are employed to 1 mole of bis-(arylamino)-benzenedicarboxylic acid or the ester of the acid; the optimum amounts are 0.5 to 1.5 moles of phosphorus halide.
In addition to phosphorus oxychloride, phosphorus oxybromide, phosphorus triand pentachloride, phosphorus triand penta-bromide, and mixtures of these phosphorus halides can be used as condensing agents. The best solvents are those which have good dissolving action on the condensing agent used at the temperature of condensation and whose boiling points are between and 300 C., preferably within the range -270 C. Examples of solvents that are particularly suitable are aromatic hydrocarbons, e.g. diplrenyl, hydrogenated aromates, e.g. tetrahydronaphthalene and hexahydronaphthalene, halogenated aromates, e.g. dichlorobenzenes and trichlorobenzenes, l-chloronaphthalene and 2-chloronaphthalene, ralkylated aromates, e.g. l-methylnaphthalene and Z-ethylnapht-halene, nitrated aromates, e.g. nitrob-enzene, p-nitro-diphenyl,
for example o-nitrodiphenyl and l-nitronaphthalene, diphenyl ether, diphenyl oxide, chloronitrobenzene, the eutectic mixture of diphenyl and diphenyl oxide or other mixtures of the solvents named supra. The most preferred groups of solvents are the hydrocarbons, the halogenated hydrocarbons and the nitrated hydrocarbons.
The most favourable procedure is to heat the starting acid, for instance 2,5-bis-(arylamino)-terephthalic acid, and the solvent to about 75 to 350 C., or preferably 150 to 270 C., and to add at this temperature the phosphorus halide, if necessary dissolved in a small amount of solvent, and to stir the mass for some time a'bout 15 minutes to 5 hours depending on the starting materialat the same high temperature. The reaction product: is then precipitated. It can be Worked up as desired, e.g. diluted with a solvent such as metha nol, filtered off, washed with solvent and possibly with dilute ammonia to remove any residual acid, and then dried.
The compounds obtained are brilliant pigments insoluble in standard solvents. Being soft grained, they are particularly well suited for the pigmentation of lacquer media, printing inks and plastics in the mass. The pigmentations have good colour fastness properties, notably good fastness to light, heat and solvents, and do not show bleeding.
In the examples the parts and percentages are by weight and the temperatures in degrees centigrade.
EXAMPLE 1 To a solution of 20 parts of 2-phenylamino-5-(4'- methylphenylamino)-terephthalic acid in 480 parts of nitrobenzene at 205 is added in 2 minutes with vigorous stirring a mixture of 8.5 parts of phosphorus oxychloride and 54 parts of nitrobenzene. After stirring for a further 30 minutes at this temperature, the reaction mass is allowed to cool to 95 and 25 parts of water are added. This is followed by stirring for minutes at 95100, after which the mass is diluted at 80 with 480 parts of methanol. The precipitate is filtered off at room temperature, washed successively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum. 17.6 parts of red-violet linear 2-rnethylquinacridine-7,14-dione are obtained. The yield is 97.8% of theory. The product can be used immediately for the pigmentation of lacquer media or plastics, e.g. polyvinyl chloride, polyolefins and polystyrene.
The phosphorus oxychloride can be replaced by 20.9 parts of phosphorus tribromide or by 14 parts of phosphorus pentabromide.
Starting from the same amount of 2,5-bis-(pheny1- amino)-terephthalic acid, the linear quinacridone is obtained in almost quantitative yield.
Other solvents besides methanol can be used for dilution, e.g. ethanol, dimethyl formamide, dimethyl sulphoxide, dimethyl acetamide, N-methylformamide and pyridine.
EXAMPLE 2 A mixture of 5.9 parts of phosphorus oxychloride and 73.5 parts of trichlorobenzene is added to a mixture of parts of 2-phenylamino-5-(4-methylphenylamino)- terephthalic acid and 735 parts of trichlorobenzene at 215 in 30 minutes with constant stirring. After stirring for a further 30 minutes at this temperature the mass is allowed to cool to 95 parts of water are added, and it is then stirred for 15 minutes at 95 100 and subsequently diluted with 700 parts of methanol at 80. The precipitate is filtered off at room temperature, washed successively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum. The product is 17.9 parts of 2-methylquinacridone-7,14-dione. The yield is 99.5 of theory.
The phosphorus oxychloride can be replaced by 10.6 parts of phosphorus trichloride or 4.6 parts of phosphorus pentachloride, and the 20 parts of 2-phenylamino-5-(4'- methylphenylamino)-terephthalic acid can be replaced by 20 parts of 2,5-di-(4'-methylphenylamino)-terephthalic acid, the procedure being otherwise the same as above.
The solvent trichlorobenzene can be replaced by the same amount of one of the following: nitrobenzene, 1- or 2-chloronaphthalene, l-methylnaphthalene, 2-ethylnaphthalene, hexahydronaphthalene, or tetrahydronaph thalene, and the reaction can be effected at temperatures up to the boiling point of these solvents.
The quinacridones obtained in this way can be used immediately for the pigmentation of lacquer media, printing inks or plastics, e.g. polyvinyl chloride, polyolefins and polystyrene. If desired, they can be purified, e.g. by precipitation from solution in 70-85% sulphuric acid.
EXAMPLE 3 7.6 parts of phosphorus oxychloride are added to a mixture of 20 parts of 2-phenylamino-5-(4'-methylphenylamino)-terephthalic acid and 440 parts of trichlorobenzene at 25. The reaction mixture is constantly stirred and its temperature continuously increased as follows: from 25 to in 3 hours, from 75 to in 6 hours, from 100 to in 14 hours, from 110 to 185 in 4 hours, and from 185 to 200 in 4 /2 hours. It is then cooled to 95 and 25 parts of water are added. After stirring for 15 minutes at 95100 the product is isolated and worked up as described in Example 1, with vacuum drying at 60. 17.3 parts of 2-methylquinacridine-7,14-dione are obtained. The yield is 96% of theory.
EXAMPLE 4 A mixture of 11.9 parts of phosphorus oxychloride and 54 parts of nitrobenzene is added to a mixture of 20 parts of 2-phenylamino-5-(4'-methylphenylamino)-terephthalic acid and 480 parts of nitrobenzene at in 2 minutes with thorough stirring.
Stirring is continued for 30 minutes at this temperature, then the mass is cooled to 95, 25 parts of water are added, stirring is resumed for 15 minutes at 95-100, and the mass finally diluted with 480 parts of methanol at 80. The precipitate is filtered ott at room temperature, washed consecutively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum.
14.8 parts of red-violet linear 2-methylquinacridine-7, 14-dione are obtained. The yield is 82.2% of theory. The product can be used immediately for pigmentation.
EXAMPLE 5 A solution of 22.1 parts of phosphorus oxychloride and 73.5 parts of trichlorobenzene is added to a mixture of 20 parts of 2,5-di-(3-chlorophenylamino)-terephthalic acid and 735 parts of trichlorobenzene at 215 in 30 minutes with stirring. The procedure is the same as that of Example 2. The product, 3,10-dichloroquinacridine-7,14-dione, is obtained in good yield. In place of phosphorus oxychloride the equivalent amount of phosphorus oxybromide can be employed with equal success.
The 20 parts of 2,5-di-(3'-chlorophenylamino)-terephthalic acid can be replaced by 20 parts of 2,5-di-(2'- chlorophenylamino)-terephthalic acid or by 20 parts of 2,5-di-(4'-chlorophenylamino)-terephthalic acid.
In the table below are set forth further quinacridine-7, 14-diones which are obtainable according to the procedures detailed in the foregoing examples. They are formed by ring closure of a 2,5-diarylaminoterephthalic acid of the formula nooo- NH-A which can also be employed in the form of its esters, preferably its low molecular alkyl esters, having from 1 to about 4 carbon atoms in the alcohol radical, e.g. its
methyl or ethyl esters, and are characterised in the table by the radicals A and B.
EXAMPLE 30 A mixture of 5.9 parts of phosphorus oxychloride and 73.5 parts of trichlorobenzene is added in 30 minutes with stirring to a mixture of parts of 2-phenylamino- 5-(4-chlorophenylamino)-terephthalic acid and 735 parts of trichlorobenzene at 215. Stirring is continued for a further minutes at this temperature. The obtained precipitate is filtered oil at room temperature, washed successively with methanol, dilute aqueous ammonia, and water, and dried at 60 in vacuum. 17 parts of 2-chloroquinacridine-7,14-dione are obtained.
The 20 parts of 2-phenylamino-5-(4-chlorophenylamino)-terephthali-c acid can be replaced by 20 parts of 2-phenylamino-5- (2-chlorophenylamino -terephthalic acid or 2-phenylamino-5-(3-chlorophenylamino)-terephthalic acid and the process performed under the same conditions as above.
Having thus disclosed the invention what I claim is:
1. Process for the production of linear quinacridine-7 14-diones which comprises heating to a temperature between 75 and 350 C. a
2,S-diarylamino-terephthalic acid of the formula wherein each of A and B represents the atoms necessary for the completion of a cyclic radical selected from the class consisting of unsubstituted phenyl, phenyl substituted by 1 lower alkyl group, phenyl substituted by 1 nitro group, phenyl substituted by 1 lower alkoxy group, phenyl substituted by 1 cyan group, phenyl substituted by 1 methylsulfonyl group, phenyl substituted by 1 to 3 halogen atoms, naphthyl, pyrenyl and car-bazyl, the acid of Formula I containing no more than 4 substituents in phenylamino radicals,
in the presence of from 0.4 to 3 moles of a phosphorus halide with reference to 1 mole of the acid of Formula, I, said phosphorus halide being a member selected from the group consisting of phosphorus oxychloride, phosphorus oxybromide, phosphorus trichloride, phosphorus pentachloride, phosphorus tribromide and phosphorus pentabrornjde,
and in the presence of an organic solvent for the phos phorus halide which is selected from the class consisting of hydrocarbons, halogenated hydrocarbons and nitrated hydrocarbons with boiling points between and 300 C.
2. Process according to claim 1, wherein the phosphorus halide is phosphorus oxychloride.
3. Process according to claim 1, wherein heating is effected in the presence of trichlorobenzene.
4. Process according to claim 1, wherein heating is effected in the presence of nitroben-zene.
5. Process for the production of linear quinaoridine-7, 14-diones which comprises heating to a temperature between to 270 C. a 2,5-diarylamino-terephthalic acid of the formula COOH COOH
wherein each of A and B represents the atoms necessary for the completion of a cyclic radical selected from the class consisting of unsubstituted phenyl, phenyl substituted by 1 lower alkyl group, phenyl substituted by 1 nitro group, phenyl substituted by 1 lower alkoXy group, phenyl substituted by 1 cyan group, phenyl substituted by 1 methylsultfonyl group, phenyl substituted by 1 to 3 halogen atoms, naphthyl, pyrenyl and carbazyl, the acid of Formula I containing no more than 4 substituents in phenylamino radicals, in the presence of from 0.5 to 1.5 moles of phosphorus oxychloride with reference to 1 mole of the acid of Formula I and in the presence of an organic solvent for the phosphorus halide which is selected from the class consisting of hydrocarbons, halogenated hydrocarhons and nitrated hydrocarbons with boiling points between 150 to 270 C.
References Cited by the Examiner UNITED STATES PATENTS OTHER REFERENCES Albert: The Acridines, pp. 24 27 (1951). Liebermann: Liebigs Annalen, vol. 518, pp. 245-259 ALEX MAZEL, Primal Examiner. JOHN D. RANDOLPH, Examiner.
DON M. KERR, DONALD G. DAUS,
Assistant Examiners.
Claims (1)
- 5. PROCESS FOR THE PRODUCTION OF LINEAR QUINACRIDINE-6, 14-DIONES WHICH COMPRISES HEATING TO A TEMPERATURE BETWEEN 150* TO 270*C. 2,5-DIARY-LAMINO-TEREPHTHALIC ACID OF THE FORMULA
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Application Number | Priority Date | Filing Date | Title |
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CH589262A CH404034A (en) | 1962-05-15 | 1962-05-15 | Process for the preparation of linear quinacridine diones |
CH914462A CH419393A (en) | 1962-05-15 | 1962-07-31 | Process for the preparation of linear quinacridine diones |
CH914562A CH419394A (en) | 1962-05-15 | 1962-07-31 | Process for the preparation of linear quinacridine diones |
CH451963A CH419396A (en) | 1962-05-15 | 1963-04-09 | Process for the preparation of linear quinacridine diones |
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BE (1) | BE632114A (en) |
CH (3) | CH419394A (en) |
DE (1) | DE1250033B (en) |
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US6537362B1 (en) | 2000-11-10 | 2003-03-25 | Sun Chemical Corporation | Polyphosphoric acid swelling of organic pigments |
US7427323B1 (en) | 2007-06-07 | 2008-09-23 | Xerox Corporation | Quinacridone nanoscale pigment particles |
US7427324B1 (en) | 2007-06-07 | 2008-09-23 | Xerox Corporation | Methods of making quinacridone nanoscale pigment particles |
US7534294B1 (en) | 2008-04-14 | 2009-05-19 | Xerox Corporation | Quinacridone nanoscale pigment particles and methods of making same |
US7537654B1 (en) | 2008-09-15 | 2009-05-26 | Xerox Corporation | Quinacridone nanoscale pigment particles and methods of making same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2830990A (en) * | 1956-01-13 | 1958-04-15 | Du Pont | Organic pigment |
FR1233785A (en) * | 1958-07-29 | 1960-10-12 | Sandoz Ag | Quinacridine-7.14-dione series pigment dyes, method of manufacture and applications |
US3020279A (en) * | 1959-03-18 | 1962-02-06 | Allied Chem | Preparation of quinacridone pigments |
US3021334A (en) * | 1962-02-13 | Process for n-methylacridone |
-
0
- DE DENDAT1250033D patent/DE1250033B/en active Pending
- BE BE632114D patent/BE632114A/xx unknown
- NL NL292723D patent/NL292723A/xx unknown
-
1962
- 1962-07-31 CH CH914562A patent/CH419394A/en unknown
- 1962-07-31 CH CH914462A patent/CH419393A/en unknown
-
1963
- 1963-04-09 CH CH451963A patent/CH419396A/en unknown
- 1963-05-09 US US279337A patent/US3261837A/en not_active Expired - Lifetime
- 1963-05-10 GB GB18584/63A patent/GB1037774A/en not_active Expired
- 1963-05-14 ES ES288058A patent/ES288058A1/en not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3021334A (en) * | 1962-02-13 | Process for n-methylacridone | ||
US2830990A (en) * | 1956-01-13 | 1958-04-15 | Du Pont | Organic pigment |
FR1233785A (en) * | 1958-07-29 | 1960-10-12 | Sandoz Ag | Quinacridine-7.14-dione series pigment dyes, method of manufacture and applications |
US3020279A (en) * | 1959-03-18 | 1962-02-06 | Allied Chem | Preparation of quinacridone pigments |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6537362B1 (en) | 2000-11-10 | 2003-03-25 | Sun Chemical Corporation | Polyphosphoric acid swelling of organic pigments |
US7427323B1 (en) | 2007-06-07 | 2008-09-23 | Xerox Corporation | Quinacridone nanoscale pigment particles |
US7427324B1 (en) | 2007-06-07 | 2008-09-23 | Xerox Corporation | Methods of making quinacridone nanoscale pigment particles |
US7534294B1 (en) | 2008-04-14 | 2009-05-19 | Xerox Corporation | Quinacridone nanoscale pigment particles and methods of making same |
US7537654B1 (en) | 2008-09-15 | 2009-05-26 | Xerox Corporation | Quinacridone nanoscale pigment particles and methods of making same |
Also Published As
Publication number | Publication date |
---|---|
BE632114A (en) | |
CH419393A (en) | 1966-08-31 |
NL292723A (en) | |
GB1037774A (en) | 1966-08-03 |
CH419396A (en) | 1966-08-31 |
CH419394A (en) | 1966-08-31 |
DE1250033B (en) | 1967-09-14 |
ES288058A1 (en) | 1963-12-16 |
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