US3112746A - Oxygenator - Google Patents

Oxygenator Download PDF

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Publication number
US3112746A
US3112746A US610605A US61060556A US3112746A US 3112746 A US3112746 A US 3112746A US 610605 A US610605 A US 610605A US 61060556 A US61060556 A US 61060556A US 3112746 A US3112746 A US 3112746A
Authority
US
United States
Prior art keywords
blood
oxygenator
envelope
sheets
passageway
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US610605A
Other languages
English (en)
Inventor
Theodore H Gewecke
Cyrus R Broman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE559148D priority Critical patent/BE559148A/xx
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Priority to US610605A priority patent/US3112746A/en
Priority to FR1181334D priority patent/FR1181334A/fr
Priority to GB29184/57A priority patent/GB871744A/en
Priority to CH356564D priority patent/CH356564A/de
Priority to DEG22943A priority patent/DE1197583B/de
Application granted granted Critical
Publication of US3112746A publication Critical patent/US3112746A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A61M1/322—Antifoam; Defoaming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung

Definitions

  • the device of our invention is an improvement on the oxygenator described in an article by Dr. Lillehei in Diseases of the Chest, volume XXIX, No. 1, January 1956.
  • Our invention has several significant advantages over the ox genator provided by those previous in the art. Of outstanding importance is its inexpensiveness of cost. Employing, as it does, heat-scalable thermoplastic material constructed into a unitary device, it is relatively inexpensive to produce. Thus, its use is imrnediately available to many more patients than the cumbersome, expensive arrangements previously described. Being of a flexible material, it is compactly transported and stored. Because of its unitary nature, it is immediately available for use without the need for making tedious connections.
  • the oxygenator of our invention is intended for use with conventional pumping equipment and tubular conduits connecting the device to a major heart vein and heart artery.
  • Our oxygenator includes a pair of heatsealable, thermoplastic materials in sheet form, heat sealed together to provide chambers for receiving oxgenation and defoaming of venous blood from a patient having an immobilized heart.
  • FIG. 1 is a schematic View of an artificial heart-lung system
  • FIG. 2 is an elevational view of the oxygenator of our invention
  • FIG. 3 is a cross-sectional view taken along the lines 33 of FIG. 2.
  • the numeral 1d designates the oxygenator of our invention.
  • Conduit 11 connects a source of venous blood of a human being to oxygenator 10.
  • a source might be the superior and inferior vena cavae.
  • this carbon dioxide-bearing blood is intimately contacted with pure oxygen entering through conduit 12.
  • the excess gases are vented from oxygenator it ⁇ through vent 13.
  • the oxygenated blood now designated arterial blood, leaves oxygenator 10 through conduit 14 and returns to the patients arterial system. This entry can be made through the aorta which is reached by making a small slit in the subclavian artery, the main channel to the left arm.
  • pumps designated P Aiding in the flow of blood to and from oxygenator 1b are pumps designated P which conveniently may take the form of a finger pump.
  • a source of heart to maintain the oxygenator and its associated blood at the proper temperature.
  • a source of heart is designated H in FIG. 1 and conveniently may assume the form of a heat lamp.
  • oxygenator 10 is shown in enlarged and detailed form. Also shown as communicating, flexible plastic tubes communicating with oxygenator ltd are conduits ll, 12 and 14 previously referred to in connection with FIG. 1.
  • the oxygenator of our invention is essentially rectangular and is constructed of two fiat sheets of heat-scalable, translucent plastic material arranged in face-to-face relation and heat sealed along the longer sides and one end thereof as indicated at 15 and 16. Also heat sealed to the sealed end of oxygenator it? is a plastic hanger strap 17 which permits convenient supporting of oxygenator it from a vertical standard such as shown in partial form and designated 13.
  • a modification employs the provision of a second heat seal parallel to and spaced from 16, the portions of side seals 15 being open between the two spaced seals, permitting the insertion of a rod so that the oxygenator is suspended like a curtain.
  • the two sheets comprising the main body portion of the oxygenator are disposed in faceto-face, lay-fiat relationship as can be appreciated from a consideration of FIG. 3 wherein a portion of the oxygenator is shown in cross section.
  • one sheet is designated 19 and the other sheet 29.
  • Sheets 19 and 21') are heat sealed together along three of their sides as at 15 and 16, as indicated above.
  • the sheets are additionally heat sealed along a longitudinal line parallel to seals 15 and located between the two sides, but closer to one of the side seals 15 as is designated 21 in F G. 2.
  • the longitudinal passage or chamber achieved by the cooperation of one seal 15 and seal 21 is used as an oxygenating or bubbling chamber.
  • the end 22 of this chamber 23 opposite heatsealed end 116 is closed by a lateral heat seal 22a. Conduits it and 12 are heat sealed into this seal so as to communicate with chamber 23..
  • the end of chamber 23 adjacent sealed end 16 communicates with the remaining portion :of the envelope formed by heat sealing sheets 19 and 24? together.
  • This major remaining portion of the envelope is provided with a series of heat seals along transverse lines, generally designated 24.
  • One transverse line 244:, along which sheets 19 and it are heat sealed together, is generally of a V configuration, one end of the V beginning at the end of heat seal 21.
  • the trapezoidal chamber adjacent the top of chamber 23 and formed by heat seals in", lo and 2 in, is employed as a debubbling or detoaming chamber.
  • the interior walls of the envelope are siliconized at this area to more readily cause oxygen and other entrapped gas such as carbon dioxide, to leave the blood.
  • the freed gas then may issue through vent 13 provided in heat seal 15 at one side of the de
  • a filter 14a is heat seal d into the exit portion of the zigzag passageway and communicates wi h conduit 14-.
  • our oxygenator is significantly superior to prior devices in employing an oxygenating device wherein the wals defining a blood flow passage are in face-to-face relation, producing a film-type flow of blood. promotes the stripping of a maximum amount of gas from the blood, which gas, if permitted to remain, might cause an embolism.
  • a unitary, disposable blood oxygenator comprisprising a flexible envelope constructed of a pair of plastic sheets in face-to-face relationship, with the side and upper edges thereof united by a heat seal, further heat seal lines connecting the sheets within the periphery of the envelope defining a passageway through the envelope, a pair of inlets at one end of the passageway, one inlet being connected to an oxygen source and the other inlet adapted to be connected to a supply of venous blood, at least one aperture through the upper portion of the envelope for connecting the passageway with the atmosphere, and an outlet at the other end of the passageway for discharging the oxygenated blood.
  • the improved oxygenation device which comprises a unitary disposable plastic blood oxygenator comprising a flexible envelope constructed or" a pair of plastic sheets in face-to-face relationship with the side and upper edges thereof united by a seal, further seals connecting the sheets within the periphery of the envelope thus defining a passageway through the envelope, a pair of inlets at one end of the passag way,
  • one inlet being adapted for connection to an oxygen source and the other inlet adapted to be connected to a supply or" blood, at least one aperture through the upper portion of the envelope for connecting the passageway with the atmosphere and an outlet at the other end of the passageway for discharging the oxygenated lood.
  • the improved oxygenator which comprises a unitary, disposale blood oxygenator, comprising a pair of substantially rectangular sheets of thermoplastic material disposed in face-to-face, lay-fiat relation and joined together along the two longer sides and an end to form an open-ended envelope, said envelope sheets being additionally joined together along a line parallel to and intermediate said sides to form a narrow, elongated oxygenating chamber, the intermediate joint extending from the open end of said e velope to a point spaced from the closed end of said envelope, the end of said oxygenating chamber adjacent the open end of said envelope being closed except for passages for introduction of venous blood and oxygen into said chamber, said envelope sheets being additionally joined together along a transverse line to provide with the envelope end joint a de-foaming chamber adjacent the end of said oxygenating chamber adjacent the closed end of said envelope, and said sheets being additionally joined together along spaced pairs of transverse lines to provide a zigzag passage
  • an oxygenation system comprised of a source of blood, a source of oxygen and an oxygenator
  • the improved oxygenator which comprises a pair of generally rectangular thermoplastic sheets arranged in faceto-face, vertical relation, said sheets being united together along the upper end and two vertical sides thereof, hanger means associated with said upper end to support said device, said sheets being united together along a vertically-extending line adjacent one of said vertical sides, said vertically-extending line terminating a spaced distance from said upper end, the space between said vertically-extending line and said adjacent one vertical side providing an oxygenating chamber with the lower end thereof being closed except for entrance means for blood and oxygen, said sheets being additionally united along a second line extending generally transversely and downwardly from the upper end of said vertically-extending line and terminating adjacent to but spaced from the vertical side remote from said vertically-extending line to provide a de-foaming chamber, said de-foaming chamber being provided with gas venting means to vent excess gases to the atmosphere, said sheets being still further united along a pair of generally parallel, inclined lines,

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
US610605A 1956-09-18 1956-09-18 Oxygenator Expired - Lifetime US3112746A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BE559148D BE559148A (enrdf_load_stackoverflow) 1956-09-18
US610605A US3112746A (en) 1956-09-18 1956-09-18 Oxygenator
FR1181334D FR1181334A (fr) 1956-09-18 1957-08-20 Dispositif pour oxygéner le sang
GB29184/57A GB871744A (en) 1956-09-18 1957-09-17 An improved oxygenator
CH356564D CH356564A (de) 1956-09-18 1957-09-18 Gerät zur Behandlung von Blut mit Sauerstoff
DEG22943A DE1197583B (de) 1956-09-18 1957-09-18 Geraet zur Behandlung von Blut mit Sauerstoff

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US610605A US3112746A (en) 1956-09-18 1956-09-18 Oxygenator

Publications (1)

Publication Number Publication Date
US3112746A true US3112746A (en) 1963-12-03

Family

ID=24445702

Family Applications (1)

Application Number Title Priority Date Filing Date
US610605A Expired - Lifetime US3112746A (en) 1956-09-18 1956-09-18 Oxygenator

Country Status (6)

Country Link
US (1) US3112746A (enrdf_load_stackoverflow)
BE (1) BE559148A (enrdf_load_stackoverflow)
CH (1) CH356564A (enrdf_load_stackoverflow)
DE (1) DE1197583B (enrdf_load_stackoverflow)
FR (1) FR1181334A (enrdf_load_stackoverflow)
GB (1) GB871744A (enrdf_load_stackoverflow)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468631A (en) * 1965-06-21 1969-09-23 Bentley Lab Blood oxygenator with heat exchanger
US3502440A (en) * 1967-07-03 1970-03-24 Baxter Laboratories Inc Blood oxygenator
US3545937A (en) * 1966-02-02 1970-12-08 Chirana Z Vdravotnickej Techni Blood oxygenation apparatus
US3994689A (en) * 1971-09-08 1976-11-30 Dewall Richard A Metabolic bubble oxygenator
US4203944A (en) * 1976-11-08 1980-05-20 Dewall Richard A Respiratory gas assembly for bubble oxygenator
US4203945A (en) * 1971-09-08 1980-05-20 Wall Richard A De Bubble oxygenator
US4637917A (en) * 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
WO2018028727A1 (de) * 2016-08-09 2018-02-15 Xenios Ag Oxygenator mit einer gehäusewandung
US11260157B2 (en) 2016-08-08 2022-03-01 Xenios Ag Oxygenator comprising a heating element

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268476A (en) * 1975-06-06 1981-05-19 Bentley Laboratories, Inc. Blood oxygenator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2784716A (en) * 1955-03-31 1957-03-12 Baxter Laboratories Inc Syringe unit
US2848995A (en) * 1949-07-06 1958-08-26 Abbott Lab Transfusion apparatus
US2854002A (en) * 1957-04-22 1958-09-30 Univ Minnesota Oxygenator

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE957877C (de) * 1953-07-07 1957-01-17 Muralto Locarno Tessin Dr. med. Federico Wehrli (Schweiz) Gerät zum Behandeln von Blut, Blutplasma od. dgl. mit Sauerstoff und gegebenenfalls mit ultraviolettem Licht

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2848995A (en) * 1949-07-06 1958-08-26 Abbott Lab Transfusion apparatus
US2784716A (en) * 1955-03-31 1957-03-12 Baxter Laboratories Inc Syringe unit
US2854002A (en) * 1957-04-22 1958-09-30 Univ Minnesota Oxygenator

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468631A (en) * 1965-06-21 1969-09-23 Bentley Lab Blood oxygenator with heat exchanger
US3545937A (en) * 1966-02-02 1970-12-08 Chirana Z Vdravotnickej Techni Blood oxygenation apparatus
US3502440A (en) * 1967-07-03 1970-03-24 Baxter Laboratories Inc Blood oxygenator
US3994689A (en) * 1971-09-08 1976-11-30 Dewall Richard A Metabolic bubble oxygenator
US4203945A (en) * 1971-09-08 1980-05-20 Wall Richard A De Bubble oxygenator
US4203944A (en) * 1976-11-08 1980-05-20 Dewall Richard A Respiratory gas assembly for bubble oxygenator
US4637917A (en) * 1983-10-14 1987-01-20 Reed Charles C Bubble oxygenator
US11260157B2 (en) 2016-08-08 2022-03-01 Xenios Ag Oxygenator comprising a heating element
WO2018028727A1 (de) * 2016-08-09 2018-02-15 Xenios Ag Oxygenator mit einer gehäusewandung
CN109937058A (zh) * 2016-08-09 2019-06-25 伊克尼奥斯股份有限公司 具有壳体壁的氧合器
US20190209763A1 (en) * 2016-08-09 2019-07-11 Xenios Ag Oxygenator with a housing wall
JP2019524285A (ja) * 2016-08-09 2019-09-05 ゼニオス アーゲー 筐体壁を有する酸素供給器
US11826502B2 (en) * 2016-08-09 2023-11-28 Xenios Ag Oxygenator with a housing wall

Also Published As

Publication number Publication date
FR1181334A (fr) 1959-06-15
BE559148A (enrdf_load_stackoverflow)
DE1197583B (de) 1965-07-29
GB871744A (en) 1961-06-28
CH356564A (de) 1961-08-31

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