US3108591A - Syringe - Google Patents

Syringe Download PDF

Info

Publication number
US3108591A
US3108591A US198521A US19852162A US3108591A US 3108591 A US3108591 A US 3108591A US 198521 A US198521 A US 198521A US 19852162 A US19852162 A US 19852162A US 3108591 A US3108591 A US 3108591A
Authority
US
United States
Prior art keywords
barrel
needle
stopper
ampule
cap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US198521A
Other languages
English (en)
Inventor
Kolbas John Michael
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BRISTOL MYCRS Co
BRISTOL-MYCRS Co
Original Assignee
BRISTOL MYCRS Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE632994D priority Critical patent/BE632994A/xx
Priority to NL293244D priority patent/NL293244A/xx
Application filed by BRISTOL MYCRS Co filed Critical BRISTOL MYCRS Co
Priority to US198521A priority patent/US3108591A/en
Priority to ES0288232A priority patent/ES288232A1/es
Priority to GB21325/63A priority patent/GB973624A/en
Priority to CH666263A priority patent/CH403165A/de
Priority to AT434563A priority patent/AT245722B/de
Priority to FR936358A priority patent/FR1358143A/fr
Application granted granted Critical
Publication of US3108591A publication Critical patent/US3108591A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps

Definitions

  • This invention relates to hypodermic syringes and more particularly to hypodermic syringes for use in the adminlistration of medicaments which are unstable in water and which require dissolution by the addition of water or other liquids before they are injected.
  • medicaments for hypodermic injections prepared in advance in exact dosages.
  • some medicaments may be a powder and a diluent or two liquids, stored 1n a segregated 'manner and mixed just prior totheir injection. This is especially true, for example, when injecting drugs such ⁇ as the new penicillins and some tetracyoline derivatives which are unstable in water.
  • Hypodermic syringes have been provided with an ampule adapted to contain the ingredients of a medicament in a segregated manner, ⁇ and these syringes have been provided with various means for mixing and discharging the contents of the ampule.
  • hypodermic syringes have a common detect, viz., they contarn a great number of parts, and consequently they are expensive to manufacture and awkward to operate. It is believed that this factor is responsible lfor the absence from the market at the present time of a hypodermic syringe of this nature.
  • hypodermic syringe of simple construction which will be adapted to contain the :ingredients of a medicament in ⁇ a segregated manner and mix these ingredients in the syringe just prior to an injection.
  • ⁇ lt is a unther object of this invention to provide a hypodermic syringe adapted to hermetically seal a liquid in' the barrel or body oi the syringe.
  • lt is a further ⁇ object of this invention to provide a hypodermic syringe having a cannular needle for making an injection and acting as a passageway to communicate the segregated contents of the hypodermic syringe.
  • -It is a further object of this invention to provide a hypodermic syringe having a cap member adapted to seal the needle and act as a plunger handle for discharging the contents of the syringe.
  • llt is a still further object of this invention to provide a hypodermic needle having few par-ts with theattendant advantages of ease in sterilization and economy in manufacture.
  • FIGURE l is a longitudinal sectional view of the hypodermic syringe ⁇ of this invention.
  • FIGURE 2 is a longitudinal section of the syringe showing the ampule almost fully seated therein;
  • FEGURE 3 is a longitudinal section of the syringe showing the ampule fully seated therein.
  • the hypodermic syringe of this invention will be seen to include a hollow barrel or body member lll having a closed end with a reduced frusto-conical portion lll.
  • the opposite end of the barrel is open, and it has an integral annular ilange which may be used as a linger grip when handling the hypodcrmic syringe.
  • a standard cannular needle l2 is securely mounted in an axial passageway in the frustoconical portion of the barrel l0. ylt will be noted that this needle is pointed at both of its ends and that a substantial portion of the needle extends within the closed end of the barrel.
  • a small aperture 13 is provided in the Wall of the needle l2 at a point therealong so that the aperture l will be just inside of the hollow barrel lil.
  • the barrel l@ is preferably made of glass, but, of course, it may be made of ⁇ any suitable material. Preferably, these materials will be transparent.
  • a cap lo which may be made of plastic, is provided to cover and maintain the sterility of the portion of the needle l2 projecting from the barrel. Additionally, this cap serves the dual function of ⁇ acting as ⁇ a seal for the outer end of the needle l2 and acting as a plunger handle for discharging the mixed medicament from the hypodermic syringe.
  • the cap 14 contains an axial bore i5 opening into ⁇ a tapering portion lo which is frictionally engageable with the rusto-conical portion 1l of the barrel ttl.
  • a threadable connection, or any other suitable connecting means, ray be provided for detachably securing the cap l@ to the barrel it?.
  • a sealant 1.7 of soft rubber, cotton or the like Disposed in the innermost portion of the
  • a hub portion 1S having a plurality ot threads thereon adapting the cap for use as an operating handle in discharging the contents ot the syringe. This feature will be referred to in greater detail below.
  • An integral annular flange 19 is provided at the other end of the cap 14 to allow the cap to be more easily grasped by a person.
  • An ampule generally designated 2%, includes an openended tube 2l having a stopper 22 in one of its ends land a stopper 23 in its other end.
  • the forwardmost stopper 22 has ⁇ an annular portion 2f@ adapted .to it snugly -in the tube 2i and an enlarged portion 25 adapted to ht snugly in the barrel lt.
  • lt is not essential, of course, that a portion of the stopper 22 extend into the tube, but this is the preferred embodiment.
  • this enlarged portion 25, which has a diameter substantially the same as the inside diameter of the barrel lt?, is ⁇ adapted to act as a piston for expelling a liquid from the chamber to delined by the innermost portion or" the barrel and the stopper 22,.
  • the rearwardmost stopper 2.3 which fits wholly within the tube 2l, deiines with the stopper 22 and the tube Ztl a chamber 2.7 for 4a medicament to be injected.
  • the stopper 23 has a threaded recess 25 in ⁇ the outer face thereof adapted to receive the hub l of the cap 14.
  • the tube 2l is of ⁇ a length allowing it to be received wholly within the barrel lt? when the stopper Z2 is in its yfully seated position.
  • rlChe tube 2l may be formed from glass, plastic, or any other suitable transparent material; preferably the Stoppers are made from rubber.
  • the syringe will be supplied to the user inthe contiguration shown in HG. l.
  • a medicament Z9 in powder form is hermetically sealed in the ampule Zit.
  • a diluent 3l? is hermetically sealed in the closed end of the barrel ld by the stopper 22 of the ampule 2l?.
  • the filling of the syringe with the diluent 36 y may be accomplished by pouring the desired amount of lthe same into the barrel lll before the tampule 2l) is inserted in piace. During this step the barrel llt) is held in -a generally vertical position with the cap i4 snapped in place .thereby sealing the end of the needle l2.
  • the ampule 20 containing the medicament is inserted in the barrel lll to hermetically seal the diluent therein.
  • the cap 14 may be -temporarily removed and the needle 12 pointed in an upward direction. This action will allow air to escape, and it will prevent loss of the diluent.
  • rille cap 1li is replaced after the ampule 20 is inserted in the barrel 1i? to a position where the stopper 22 is just out ⁇ of contact with the inner pointed end of the needle 12.
  • the syringe may be filled with a diluent by placing a hollow tube of small diameter against the inside wall of the barrel 1i!
  • the hypodermic syringe is shipped in the conguration of FIG. 1. It is preferably packaged in a container designed to preclude accidental insertion ⁇ of the ampule 2i? to a point where the stopper 22 ⁇ would Contact the pointed end of the needle 12..
  • the hypodermic syringe When it is desired to make an injection, the hypodermic syringe is removed from the package and the ⁇ ampule is driven home in the barrel 1t) by engaging the outer end of the ampule with the palm of ⁇ ones hand.
  • the stopper 22 will be pierced bly the inner pointed end of the needle 12.
  • the chamber 2,6 By virtue of the aperture 13 and the hollow needle 12, the chamber 2,6 will be placed in communication with the chamber 27. Accordingly, continued inward movement of the ampule Ztl will force the liquid from the chamber 26 through the aperture 13 and the needle 12 into the chamber 27 where it will be allowed to mix with the medicament 29.
  • the stopper 22 arrives at its fully seated position in the barrel 16, it will have completely discharged the diluent and at the same time sealed the aperture 13.
  • the hypodermic needle is now given ⁇ a shaking action to completely mix the contents in the ampule 20.
  • hypodermic syringe of this invention provides a means to make this test. Since the cap 14 is attached to the stopper 23, the latter may be withdrawn slightly before an injection is made. If blood appears in the ampule, the user of the syringe will know that the injection will be intravenous. During this rearward movement of the stopper Z3, it may be necessary to place ones thumbnail over the outer end of the ampule 20 to prevent it from being withdrawn from the barrel 16.
  • hypodermic syringe of this invenl tion has been illustrated by referring -to the mixing of a medicament in powder form with a diluent. However, it will ybe understood that this is not to be taken as limiting the adaptability of this invention in that the hypodermic syringe may be used to mix and discharge medicaments in other suitable forms.
  • hypodermic syringe which is simple in construction and which will maintain the ingredients of a medicament in a segregated manner and allow them to be easily mixed and discharged ⁇ when an injection is desired to be made.
  • the entire hypodermic syringe L may be considered as disposable since all parts of the syringe are simple in construction and inexpensive to manufacture. It may be desired to retain and re-sterilize the barrel and needle, as this is the most expensive single unit of the syringe.
  • the ampule Z@ and cap 14 may be disposed of with little economic loss.
  • Another advantage resulting from the simplicity of construction of the hypodermic syringe of this invention resides in the ease by which it may be highly sterilized.
  • a hypodermic syringe comprising, a barrel being open at one end and closed at its opposite end, a hollow needle being pointed at beth ends thereof and being secured in the ⁇ closed end of said barrel with ⁇ one end extending into said barrel, an aperture in the wall of said needle in the portion thereof extending into said barrel, removable sealing means sealing the end of said needle extending outside of said barrel ⁇ and an elongated ampule received in the open end of said barrel and having a stopper in each end thereof for containing a medicament, the forwardrnost of said Stoppers having a diameter substantially the same as the inside diameter of said barrel and adapted to seal a diluent in the forward portion of said barrel, said forwardmost stopper adapted to be punctured by the inner end of said needle for communicating said diluent with said medica-ment, and the rearwardmest of said stoppe-rs adapted to act as a plunger for discharging the contents of said ampule.
  • a hypoderrnic syringe comprising, a barrel being open at one end and closed at its opposite end, a hollow needle being pointed at both ends thereof and being sccured in the closed end of said ⁇ barrel with one end extending into said barrel, an aperture in the wall of said needle in the portion thereof extending into said barrel, a removable cap engaged with the closed end of said barrel for enclosing said needle :and having a sealant therein for sealing the outer end of Asaid needle, an elongated ampule received in the open end of said barrel and having a stopper in each end thereof for ⁇ containing a medicament, the forwardmost of said Stoppers having a hollow cylindrical portion adapted to iit within said ampule and having a solid portion with a ⁇ diameter substantially the same as the inside diameter of said barrel, said forwardmoet stopper adapted to act as a piston and a seal for a diluent in the forward portion of said barrel, said solid portion of said forwardmost stopper adapted to
  • a hypoderniic syringe according to claim 3 wherein said cap comprises a cylindrical member having an open end frictionally engageable with the closed end of said barrel and having a closed end adapted tto contain a sealant for sealing said needle, said cap having attachi ment means on its lclosed end for engaging said rearwardmost stopper.
  • a hypoderrnic syringe according to claim 3 wherein ⁇ said yarmgmle is of a length allowing it to be received whollywithin said barrel when said forwardmost stopper covers ⁇ said aperture in said needle.
  • a hypodermic syringe comprising, a barrel being open Xat one end and closed at its opposite end, a hollow needle being pointed at both 1ends thereof and being secured in the closed end of said barrel with one end eX- tending into said barrel, an aperture in the wall of said needle in the pontion thereof extending into ⁇ said barrel, an elongated cap engaged with the closed end orf said barrel for enclosing and sealing said needle, and an elongated 6 ⁇ ff ampule received in the open end of said barrel and having a ⁇ stopper in each end thereof rfor hermetically sealing a medicament therein, the forwardrnost of said Stoppers having a diameter substantially the same as the inside diameter of said barrel and defining with the 4closed end portion of said barrel la chamber lfor hermetically sealing a diluent therein, said forwardrnost stopper adapted to be punctured ⁇ by the inner end ⁇ of said needle upon forward movement of said am-pule rfor communicating said d

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US198521A 1962-05-29 1962-05-29 Syringe Expired - Lifetime US3108591A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BE632994D BE632994A (fi) 1962-05-29
NL293244D NL293244A (fi) 1962-05-29
US198521A US3108591A (en) 1962-05-29 1962-05-29 Syringe
ES0288232A ES288232A1 (es) 1962-05-29 1963-05-21 Mejoras en jeringas hipodérmicas
GB21325/63A GB973624A (en) 1962-05-29 1963-05-28 Syringe
CH666263A CH403165A (de) 1962-05-29 1963-05-28 Spritze
AT434563A AT245722B (de) 1962-05-29 1963-05-29 Injektionsspritze
FR936358A FR1358143A (fr) 1962-05-29 1963-05-29 Seringue hypodermique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US198521A US3108591A (en) 1962-05-29 1962-05-29 Syringe

Publications (1)

Publication Number Publication Date
US3108591A true US3108591A (en) 1963-10-29

Family

ID=22733719

Family Applications (1)

Application Number Title Priority Date Filing Date
US198521A Expired - Lifetime US3108591A (en) 1962-05-29 1962-05-29 Syringe

Country Status (7)

Country Link
US (1) US3108591A (fi)
AT (1) AT245722B (fi)
BE (1) BE632994A (fi)
CH (1) CH403165A (fi)
ES (1) ES288232A1 (fi)
GB (1) GB973624A (fi)
NL (1) NL293244A (fi)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3438549A (en) * 1967-09-29 1969-04-15 Baxter Laboratories Inc Pre-filled syringe
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3570486A (en) * 1968-10-14 1971-03-16 Horizon Ind Ltd Mixing syringe
US3911916A (en) * 1971-10-29 1975-10-14 Peter A Stevens Sequential injection syringe
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
EP0005939A1 (en) * 1978-05-31 1979-12-12 Rudolph J. Kopfer Compartmental syringe
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
US4589421A (en) * 1984-03-14 1986-05-20 Syntex (U.S.A.) Inc. Sampling device
US4608997A (en) * 1985-01-25 1986-09-02 Becton, Dickinson And Company Blood collection assembly
US4620549A (en) * 1985-01-25 1986-11-04 Becton, Dickinson And Company Blood collection assembly
US4747829A (en) * 1987-01-21 1988-05-31 E. R. Squibb & Sons, Inc. Pre-filled syringe
EP0295337A1 (en) * 1987-06-16 1988-12-21 Akzo Nobel N.V. Two compartment syringe and method of manufacturing
US4900309A (en) * 1988-06-02 1990-02-13 Fred Netherton Needle shield
US5190532A (en) * 1992-05-08 1993-03-02 Yu Wing Kwong S Cannula cap
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5531703A (en) * 1992-04-28 1996-07-02 Schering-Plough Healthcare Products, Inc. Applicator for semisolid medications
US20110176382A1 (en) * 2010-01-15 2011-07-21 Spine Wave, Inc. Systems and Methods for Mixing Fluids
WO2014081785A1 (en) * 2012-11-26 2014-05-30 Becton, Dickinson And Company Valve permitting mixing in a drug delivery device
CN108888843A (zh) * 2018-08-10 2018-11-27 中国人民解放军总医院 用于人体空腔伤口的粉末止血剂推进器
CN109011027A (zh) * 2018-08-09 2018-12-18 中国人民解放军总医院 止血剂推进器
CN109173037A (zh) * 2018-10-18 2019-01-11 广州资生生物科技有限公司 一种多功能凝胶装药装置
CN110352078A (zh) * 2016-11-01 2019-10-18 科利登医疗系统公司 用于安全注射器的系统和方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2159217A (en) * 1937-11-05 1939-05-23 Cook Lab Inc Controllable transfer element for multiple ampules
US2193322A (en) * 1938-04-30 1940-03-12 Cook Lab Inc Controllable transfer element for multiple compartment ampules
US2453590A (en) * 1946-11-04 1948-11-09 Noel J Poux Hypodermic syringe
US2490553A (en) * 1947-09-20 1949-12-06 Arthur E Smith Disposable syringe
CA493373A (en) * 1953-06-02 B. Burnside Carl Syringe
US2653607A (en) * 1950-09-16 1953-09-29 Ayerst Mckenna & Harrison Injection apparatus
US2684068A (en) * 1951-02-21 1954-07-20 Sindey R Orens Syringe
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2834346A (en) * 1955-06-06 1958-05-13 Becton Dickinson Co Syringe and hub locking assembly

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA493373A (en) * 1953-06-02 B. Burnside Carl Syringe
US2159217A (en) * 1937-11-05 1939-05-23 Cook Lab Inc Controllable transfer element for multiple ampules
US2193322A (en) * 1938-04-30 1940-03-12 Cook Lab Inc Controllable transfer element for multiple compartment ampules
US2453590A (en) * 1946-11-04 1948-11-09 Noel J Poux Hypodermic syringe
US2490553A (en) * 1947-09-20 1949-12-06 Arthur E Smith Disposable syringe
US2653607A (en) * 1950-09-16 1953-09-29 Ayerst Mckenna & Harrison Injection apparatus
US2684068A (en) * 1951-02-21 1954-07-20 Sindey R Orens Syringe
US2687728A (en) * 1951-04-25 1954-08-31 Copen Simon Irving Combination of several solutions for the hypodermic injection
US2834346A (en) * 1955-06-06 1958-05-13 Becton Dickinson Co Syringe and hub locking assembly

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405712A (en) * 1966-02-07 1968-10-15 Richard L. Pierick Desiccative syringe
US3438549A (en) * 1967-09-29 1969-04-15 Baxter Laboratories Inc Pre-filled syringe
US3557787A (en) * 1968-05-28 1971-01-26 Milton J Cohen Disposable syringe
US3570486A (en) * 1968-10-14 1971-03-16 Horizon Ind Ltd Mixing syringe
US3911916A (en) * 1971-10-29 1975-10-14 Peter A Stevens Sequential injection syringe
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
EP0005939A1 (en) * 1978-05-31 1979-12-12 Rudolph J. Kopfer Compartmental syringe
US4516967A (en) * 1981-12-21 1985-05-14 Kopfer Rudolph J Wet-dry compartmental syringe
US4589421A (en) * 1984-03-14 1986-05-20 Syntex (U.S.A.) Inc. Sampling device
US4608997A (en) * 1985-01-25 1986-09-02 Becton, Dickinson And Company Blood collection assembly
US4620549A (en) * 1985-01-25 1986-11-04 Becton, Dickinson And Company Blood collection assembly
US4747829A (en) * 1987-01-21 1988-05-31 E. R. Squibb & Sons, Inc. Pre-filled syringe
EP0295337A1 (en) * 1987-06-16 1988-12-21 Akzo Nobel N.V. Two compartment syringe and method of manufacturing
US4994043A (en) * 1987-06-16 1991-02-19 Akzo N.V. Two compartment syringe
US4900309A (en) * 1988-06-02 1990-02-13 Fred Netherton Needle shield
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5531703A (en) * 1992-04-28 1996-07-02 Schering-Plough Healthcare Products, Inc. Applicator for semisolid medications
US5190532A (en) * 1992-05-08 1993-03-02 Yu Wing Kwong S Cannula cap
US20110176382A1 (en) * 2010-01-15 2011-07-21 Spine Wave, Inc. Systems and Methods for Mixing Fluids
US8657481B2 (en) * 2010-01-15 2014-02-25 Spine Wave, Inc. Systems and methods for mixing fluids
CN103830108B (zh) * 2012-11-26 2017-04-12 贝克顿·迪金森公司 用于复溶装置的阀
EP3827857A1 (en) * 2012-11-26 2021-06-02 Becton, Dickinson and Company Valve permitting mixing in a drug delivery device
US20150314071A1 (en) * 2012-11-26 2015-11-05 Becton, Dickinson And Company Valve Permitting Mixing in a Drug Delivery Device
JP2016501585A (ja) * 2012-11-26 2016-01-21 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 薬剤送達装置内での混合を可能にする弁
WO2014081785A1 (en) * 2012-11-26 2014-05-30 Becton, Dickinson And Company Valve permitting mixing in a drug delivery device
CN103830108A (zh) * 2012-11-26 2014-06-04 贝克顿·迪金森公司 用于复溶装置的阀
US10195344B2 (en) * 2012-11-26 2019-02-05 Becton, Dickinson And Company Valve permitting mixing in a drug delivery device
CN110352078A (zh) * 2016-11-01 2019-10-18 科利登医疗系统公司 用于安全注射器的系统和方法
CN110352078B (zh) * 2016-11-01 2022-02-11 科利登医疗系统公司 用于安全注射器的系统和方法
CN109011027A (zh) * 2018-08-09 2018-12-18 中国人民解放军总医院 止血剂推进器
CN109011027B (zh) * 2018-08-09 2023-10-20 中国人民解放军总医院 止血剂推进器
CN108888843A (zh) * 2018-08-10 2018-11-27 中国人民解放军总医院 用于人体空腔伤口的粉末止血剂推进器
CN108888843B (zh) * 2018-08-10 2023-06-27 中国人民解放军总医院 用于人体空腔伤口的粉末止血剂推进器
CN109173037A (zh) * 2018-10-18 2019-01-11 广州资生生物科技有限公司 一种多功能凝胶装药装置

Also Published As

Publication number Publication date
CH403165A (de) 1965-11-30
AT245722B (de) 1966-03-10
NL293244A (fi)
ES288232A1 (es) 1963-12-01
BE632994A (fi)
GB973624A (en) 1964-10-28

Similar Documents

Publication Publication Date Title
US3108591A (en) Syringe
US3330281A (en) Combination syringe and vial mixing container
US4613326A (en) Two-component medication syringe assembly
US3563373A (en) Hypodermic syringe assembly
US4518385A (en) Disposable syringe for needleless injector
US2888923A (en) New ampoule-syringe
US3678931A (en) Syringe
EP0609741B1 (en) Prefilled syringe assembly
US2834346A (en) Syringe and hub locking assembly
US3826260A (en) Vial and syringe combination
US3826261A (en) Vial and syringe assembly
US3376866A (en) Medicament injector with attached vial
EP0172990B1 (en) Two-component syringe assembly
US5445620A (en) Disposable safety syringe with retractable shuttle for Wyeth medication cartridge
US3342180A (en) Disposable liquid-powder package and hypodermic syringe
US3255752A (en) Hypodermic syringe
US5865227A (en) Prefilled hypodermic syringe system
US3841329A (en) Compact syringe
US3527216A (en) Hypodermic syringe assembly
JPH01131671A (ja) 注射器並びに注射器の組立て方法
US2671449A (en) Cartridge-syringe unit
HU182036B (en) Injection syringe as well as needle holder and recipient belonging same
JPH10295814A (ja) カニューレ密封シールドアセンブリ
US3552387A (en) Combination syringe and vial
US2768623A (en) Container for liquids, and more particularly to a container which incorporates therein the function of a syringe