US2874087A - Disinfectant compositions - Google Patents

Disinfectant compositions Download PDF

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Publication number
US2874087A
US2874087A US566095A US56609556A US2874087A US 2874087 A US2874087 A US 2874087A US 566095 A US566095 A US 566095A US 56609556 A US56609556 A US 56609556A US 2874087 A US2874087 A US 2874087A
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United States
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parts
bactericidal
disinfectant
compositions
phenols
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US566095A
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English (en)
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Obladen Albert Jakob
Deutsch Martn Kar
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system

Definitions

  • This invention relates to disinfectant or antiseptic compositions. More particularly it relates to antiseptic compositions containing mixtures of bactericidal phenolic compounds and polyhalogenated phenolates.
  • 2,698,301 effective antiseptic detergent compositions can be prepared from detergent soaps and 0.5 to 5% by weight of a pentahalogenated phenol, such compositions being stated to be effective against Staphylococci.
  • the pentahalogenated phenols are, however, substantially insoluble in water and to incorporate them in a detergent such as soap or an alkyl sulphonate, the pentahalogenated phenol is first dissolved in a suitable solvent.
  • the Water-solubility of the alkali metal phenolates increases with the alkali content but the germicidal activity thereof decreases correspondingly with the increased alkali content (see, for instance, E. Hailer in Weyls Handbuch derHygiene, 1922, vol. 8, page 1113). This decrease in germicidal power with increase in alkali content is true not only for monochlorinated phenols but also for polychlorophenols.
  • disinfectant compositions are formed of mixtures of bactericidal phenols, including phenolic derivatives, and salts of polyhalogenated phenols with inorganic or organic bases, especially pentachlorophenolates, such as sodium or potassium pentachlorophenolates.
  • the preferred disinfectant compositions of this invention comprise aqueous solutions of the phenolic mixtures and preferably include a surface-active agent, such as a soap or detergent, for example, a higher alkyl or aryl-alkyl sulphonate.
  • compositions of this invention comprise a mixture or two or more bactericidal phenols or phenolic compounds and a polyhalogenated phenolate, such as an ice alkali metal pentachlorophenolnte or pentabromophenolate.
  • effective disinfectant compositions may com prise mixtures of parachlorometacresol and also phenyl phenol in suitable relative proportions and conveniently in substantially equal proportions.
  • Such a mixture of bactericidal phenols may then be mixed with suitable proportions of a polyhalogenated phenolate, the proportion of polyhalogenated phenolate varying from about 10% by weight of the bactericidal phenol or mixture of phenols to 200% by Weight thereof or even more.
  • compositions it is economically convenient and effective as an antiseptic for the composition to contain one part of polyhalogenated phenolate per each 0.5 to 1.5 parts of bactericidal phenol, for example, substantially equal proportions of phenolates to bactericidal phenol or mixture theroef is a convenient and effective relative proportion.
  • the proportion of surface-active agent such as soap may be and preferably is a multiple of the proportion of bactericidal phenol in the mixture. Suitable proportions of soap may, however, vary from 5% by weight to 500% by weight of the bactericidal phenol in the composition. In a satisfactory disinfectant composition in accordance with this invention the proportion of soap or other surfaceactive agent is equal to 1.5 times the weight of bactericidal phenol in the mixture.
  • the composition preferably includes substantial amounts of water and in its preferred concentrated form it is a liquid composition in which the total dissolved solids amount to 5% to by weight, the balance being water, a preferred range of total solids amounting to 30 to 75% by weight of the total mixture.
  • Such solutions may be diluted many times to form effective disinfectants.
  • the compositions of this invention may also include alkali such as sodium or potassium hydroxide or other water-soluble base, in amounts not in excess of the chemically equivalent proportion to convert the bactericidal phenols into phenolates, and preferably substantially less than the equivalent proportion, for example, about half the equivalent amount.
  • solutions are prepared of mixtures -of bactericidal phenols with and without the inclusion of pentahalogenated phenolates, and the antiseptic power of the different solutions, when diluted, is compared in the subsequent tabulation.
  • the parts are by weight.
  • the soap used in Examples 1, 2 and 5 was prepared by saponifying castor oil with 4.4% by weight of potassium hydroxide in the presence of 10% methylglycol.
  • This preparation differs from Example 3 because of its sodium pentachlorophenolate content.
  • Example 5 For comparison a solution was used consisting of 18 parts soap, 10 parts sodium pentachlorophenolate, made up to 100 parts with water.
  • germicidal or bactericidal phenols having free hydroxyl groups those which are known to be satisfactory in the art of disinfecting are suitable for inclusion in the compositions of this invention, name, phenols, chlorophenols, chlorocresols, xylenols, chloroxylenols, phenylphenol, chlorophenylphenol, cyclohexylphenol, ehlorocyclohexylphenol, benzylphenol, chlorobenzylphenol, dihydroxydiphenylmethanes, dihydroxy diphenylsulphides and dihydroxydiphenyl-oxides, and their cloro derivatives, resorcinol and its derivatives such as hexylresorcinol etc.
  • Suitable polychlorophenolates for inclusion in the compositions for this invention are the salts of polychlorophenols with alkali metals, ammonia, amines or other organic bases such as the salts of -tri-, tetraand pentachloroor -bromo-phenols, triand vtetra-'chlorocresol, tetrachloroxylenol, tetrachloronaphthol and the like.
  • the compounds of higher degree of chlorination show greater germicidal capacity than do the lower.
  • the disinfectans prepared according to the invention have in practice'the same technical properties as have well known fine and coarse disinfectans of the kinds characterized by the examples.
  • the solutions have good foaming properties, they are non-irritant to the skin etc. and have only a faint inherent odor and are versatile in use.
  • a meritorious feature of the invention resides in the possibility to achieve biological effects which go quite considerably beyond those known hitherto and in some cases result in an improvement in the known effect up to even as much as twice the original figure.
  • a disinfectant composition comprising 5% to 6% of para-chloro-meta-cresol, 5% to 6% "ortho-phenylphenol, 10% alkali metalpentachloro-phenolate and the balance of a surface-active agent and water.
  • the disinfectant composition of claim 1 which comprises 10% potassium pentachl'oro-ph'enolate, and 18% soap.
  • the disinfectant composition of claim 1 which comprises 10% sodium pentachloro-phenolate, '1.'7 %"so'dium hydroxide and of a higher alkylsulphonate.
  • a disinfectant composition comprising from 5% to 25% by weight of parachlorinated cresol and'phenyl phenol, from 5% to 25% by weight of alkali metal polychlorinated phenolate, and the balance of a surface active agentand water.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
US566095A 1955-02-26 1956-02-17 Disinfectant compositions Expired - Lifetime US2874087A (en)

Applications Claiming Priority (1)

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DE340013X 1955-02-26

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US2874087A true US2874087A (en) 1959-02-17

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US566095A Expired - Lifetime US2874087A (en) 1955-02-26 1956-02-17 Disinfectant compositions

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US (1) US2874087A (enrdf_load_stackoverflow)
BE (1) BE544980A (enrdf_load_stackoverflow)
CH (1) CH340013A (enrdf_load_stackoverflow)
GB (1) GB789713A (enrdf_load_stackoverflow)
LU (1) LU34050A1 (enrdf_load_stackoverflow)
NL (1) NL95816C (enrdf_load_stackoverflow)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150662A (en) * 1961-12-07 1964-09-29 Haver Lockhart Lab Method of lubricating body cavities
US3538217A (en) * 1969-04-02 1970-11-03 Grace W R & Co Phenolic germicidal compositions
EP0553628A1 (de) * 1992-01-25 1993-08-04 Bayer Ag Fliessfähige mikrobizide Mittel
RU2298543C2 (ru) * 2000-05-12 2007-05-10 Омиа Аг Водный жидкий состав с низкой температурой замерзания, содержащий феноляты, способ его приготовления, водная суспензия или дисперсия, включающая состав
WO2007009606A3 (de) * 2005-07-19 2007-05-24 Bayer Healthcare Ag Desinfektionsmittel enthaltend eine kombination biozider und ein keratolytikum

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28778E (en) * 1969-12-23 1976-04-20 West Laboratories, Inc. Phenolic synthetic detergent-disinfectant
DE4317844A1 (de) * 1993-05-28 1994-12-01 Bayer Ag Chemisches Desinfektionsmittel auf Basis phenolischer Wirkkomponenten und Glutaraldehyd

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1248181A (en) * 1916-04-27 1917-11-27 Beaver Company Wall-board.
CA461883A (en) * 1949-12-20 K. Ballman Donald Fungicidal and bactericidal composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA461883A (en) * 1949-12-20 K. Ballman Donald Fungicidal and bactericidal composition
US1248181A (en) * 1916-04-27 1917-11-27 Beaver Company Wall-board.

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3150662A (en) * 1961-12-07 1964-09-29 Haver Lockhart Lab Method of lubricating body cavities
US3538217A (en) * 1969-04-02 1970-11-03 Grace W R & Co Phenolic germicidal compositions
EP0553628A1 (de) * 1992-01-25 1993-08-04 Bayer Ag Fliessfähige mikrobizide Mittel
US5374378A (en) * 1992-01-25 1994-12-20 Bayer Aktiengesellschaft Flowable microbicidal agents
RU2298543C2 (ru) * 2000-05-12 2007-05-10 Омиа Аг Водный жидкий состав с низкой температурой замерзания, содержащий феноляты, способ его приготовления, водная суспензия или дисперсия, включающая состав
WO2007009606A3 (de) * 2005-07-19 2007-05-24 Bayer Healthcare Ag Desinfektionsmittel enthaltend eine kombination biozider und ein keratolytikum
US20080221222A1 (en) * 2005-07-19 2008-09-11 Bayer Healthcare Llc Disinfectant
RU2419287C2 (ru) * 2005-07-19 2011-05-27 Байер Энимэл Хельс ГмбХ Дезинфицирующее средство для борьбы с паразитическими простейшими
CN101267734B (zh) * 2005-07-19 2012-05-30 拜耳动物保健有限责任公司 包含杀生物酚和角质分离剂的组合的消毒剂

Also Published As

Publication number Publication date
GB789713A (en) 1958-01-29
LU34050A1 (enrdf_load_stackoverflow)
BE544980A (enrdf_load_stackoverflow)
CH340013A (de) 1959-07-31
NL95816C (enrdf_load_stackoverflow)

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