US2779332A - Procedure for intracorporal intra-and subcutaneous test, therapy, immunization, vaccination, and drug adminstration - Google Patents
Procedure for intracorporal intra-and subcutaneous test, therapy, immunization, vaccination, and drug adminstration Download PDFInfo
- Publication number
- US2779332A US2779332A US394496A US39449653A US2779332A US 2779332 A US2779332 A US 2779332A US 394496 A US394496 A US 394496A US 39449653 A US39449653 A US 39449653A US 2779332 A US2779332 A US 2779332A
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- United States
- Prior art keywords
- instrument
- therapy
- admixture
- intracorporal
- immunization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
- A61B17/205—Vaccinating by means of needles or other puncturing devices
Definitions
- the object of our invention is to introduce into the animal economy definite quantities of various antigenic, therapeutic and immunizing (including vaccines) materials and drugs incorporated in a non-antigenic, nonallergenic material in dry form, adhering intimately to a pin or needle or like material or instrument (with various bevels and sizes for various purposes), to prevent its re moval during its insertion and yet being readily removable and soluble after contact with the tissues and remaining in situ upon removal of the pin, needle, or like instrument of insertion.
- Our invention consists of simple sharp pointed non-corrosive pins or needles, varying sizes for varying purposes, the points of which have been dipped to an appropriate depth in a non-allergenic, non-antigenic, water soluble cellulose preparation which dries rapidly in a hard film, closely adhered to the tip of the pin, needle, or like instrument.
- This water soluble cellulose preparation contains both the quantitative amount of specific antigenic or allergenic or immunizing material or drug to be used for diagnostic test, therapy, or immunization and, when desired, a small appropriate amount of water soluble nonantigenic dye or color.
- This dye or color is readily discolorized (reduced) by the tissues and absorbed before the biological reaction (allergic or antigenic) or drug idiosyncracy reactions occur and is added for the convenience of the operator in determining complete removal of the material from the tip of the pin or like instrument on withdrawal. More specifically, we have produced a workable preparation of a 5 to percent methyl cellulose solution in water, to which is added antigen, allergen, or drug, immunizing agent or vaccine in quantitatively appropriate amounts, and a readily absorbable or reducible dye or color, about 0.1 to 0.2 percent medicinal methylene blue for blue color, others for different desired colors, to designate agent and to indicate when the material is in the body and when solution occurs.
- sterile pins or like instrument for intracorporal, intracutaneo us and subcutaneous insertion are dipped into the foregoing solution and allowed to dry aseptically. After drying, the pins (or instruments) are kept or sealed in glass tubes of approximately two inches in length, 4 mm. outside diameter, sterile, scored for easy breaking to obtain pin for use, after which breakage the head of pin is grasped by operator thus eliminating chances of contamination, or other suitable receptacle ready for use.
- test or therapy or immunization or drug is administered by inserting the pin or instrument intracorporally, intracutaneously or subcutaneously after appropriate cleansing of the skin and outside of tube (alcohol, acetone, ether, etc.).
- the point is allowed to remain in situ for about 30 seconds, sufiicient time to moisten material, when it is readily removed from the pin or instrument on withdrawal under slight pressure between the fingers during withdrawal.
- the test or therapy or im atent 0 munization or drug is ready for the operator's application, and he needs no additional equipment. He has no need for a sterilizer, syringe, diluent, etc. Both pin and tube are discarded after single use.
- the method for preparing medicinal materials in suitable form for introduction in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material with an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; and allowing the portion of the admixture which has adhered to said instrument to dry into a hard film.
- aqueous methyl cellulose solution is about a 5-l0 percent methyl cellulose solution.
- the method of preparing medicinal materials in suitable form for introduction in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material, a small amount of a water soluble non-antigenic dye, and an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; and, allowing the portion of the admixture which has adhered to said instrument to dry into a hard film.
- the method for introducing medicinal materials in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material with an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; allowing the portion of the admixture which has adhered to said instrument to dry into a hard film; introducing the point of said needle-like instrument into the animal body; allowing said instrument to remain in said animal body until the hard film adhering to said instrument can be dislodged; and, removing said instrument from said animal body.
- An needle-like instrument having a dried residue of a medicinal material dispersed in a non-allergenic, nonantigenic, water-soluble carrier film intimately adhering to the pointed end of said instrument.
Description
PROCEDURE FOR INTRACORPORAL INTRA- AND SUBCUTANEOUS TEST, THERAPY, IM- MUNIZATION, VACCINATION, AND DRUG ADMINSTRATION Harry J. Corper and Catherine Clark, Denver, Colo.
No Drawing. Application November 25, 1953,
Serial No. 394,496
5 Claims. (Cl. 128--253) The object of our invention is to introduce into the animal economy definite quantities of various antigenic, therapeutic and immunizing (including vaccines) materials and drugs incorporated in a non-antigenic, nonallergenic material in dry form, adhering intimately to a pin or needle or like material or instrument (with various bevels and sizes for various purposes), to prevent its re moval during its insertion and yet being readily removable and soluble after contact with the tissues and remaining in situ upon removal of the pin, needle, or like instrument of insertion.
Our invention consists of simple sharp pointed non-corrosive pins or needles, varying sizes for varying purposes, the points of which have been dipped to an appropriate depth in a non-allergenic, non-antigenic, water soluble cellulose preparation which dries rapidly in a hard film, closely adhered to the tip of the pin, needle, or like instrument. This water soluble cellulose preparation contains both the quantitative amount of specific antigenic or allergenic or immunizing material or drug to be used for diagnostic test, therapy, or immunization and, when desired, a small appropriate amount of water soluble nonantigenic dye or color. This dye or color is readily discolorized (reduced) by the tissues and absorbed before the biological reaction (allergic or antigenic) or drug idiosyncracy reactions occur and is added for the convenience of the operator in determining complete removal of the material from the tip of the pin or like instrument on withdrawal. More specifically, we have produced a workable preparation of a 5 to percent methyl cellulose solution in water, to which is added antigen, allergen, or drug, immunizing agent or vaccine in quantitatively appropriate amounts, and a readily absorbable or reducible dye or color, about 0.1 to 0.2 percent medicinal methylene blue for blue color, others for different desired colors, to designate agent and to indicate when the material is in the body and when solution occurs. As long as the color can be seen in situ, solution has not taken place. Under aseptic precautions the cleaned (heat, acetone, gasoline, petroleum products, ether, etc.) sterile pins or like instrument for intracorporal, intracutaneo us and subcutaneous insertion are dipped into the foregoing solution and allowed to dry aseptically. After drying, the pins (or instruments) are kept or sealed in glass tubes of approximately two inches in length, 4 mm. outside diameter, sterile, scored for easy breaking to obtain pin for use, after which breakage the head of pin is grasped by operator thus eliminating chances of contamination, or other suitable receptacle ready for use.
The test or therapy or immunization or drug is administered by inserting the pin or instrument intracorporally, intracutaneously or subcutaneously after appropriate cleansing of the skin and outside of tube (alcohol, acetone, ether, etc.). The point is allowed to remain in situ for about 30 seconds, sufiicient time to moisten material, when it is readily removed from the pin or instrument on withdrawal under slight pressure between the fingers during withdrawal. The test or therapy or im atent 0 munization or drug is ready for the operator's application, and he needs no additional equipment. He has no need for a sterilizer, syringe, diluent, etc. Both pin and tube are discarded after single use. For larger amounts on larger animals, correspondingly larger tubes and pins, needles, or like instruments are used. These single tests, therapies, drugs, immunizations or vaccines are so compact and light-weight that thousands of them can be packed and transported in a very small container, thus making air transport feasible and convenient. The corrugated paper holders are protection against breakage and can be marked to avoid error or confusion in use. These may be put up as single, mass numbers, or sets of various combinations. In military and mass use, no salvage problem exists.
We claim:
1. The method for preparing medicinal materials in suitable form for introduction in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material with an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; and allowing the portion of the admixture which has adhered to said instrument to dry into a hard film.
2. The method of claim 1, wherein the aqueous methyl cellulose solution is about a 5-l0 percent methyl cellulose solution.
'3. The method of preparing medicinal materials in suitable form for introduction in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material, a small amount of a water soluble non-antigenic dye, and an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; and, allowing the portion of the admixture which has adhered to said instrument to dry into a hard film.
4. The method for introducing medicinal materials in a dry, solid state into the animal economy which includes: admixing a quantitative amount of the desired medicinal material with an aqueous methyl cellulose solution; dipping the pointed end of a sterile needle-like instrument into said admixture; removing said instrument from said admixture; allowing the portion of the admixture which has adhered to said instrument to dry into a hard film; introducing the point of said needle-like instrument into the animal body; allowing said instrument to remain in said animal body until the hard film adhering to said instrument can be dislodged; and, removing said instrument from said animal body.
5. An needle-like instrument having a dried residue of a medicinal material dispersed in a non-allergenic, nonantigenic, water-soluble carrier film intimately adhering to the pointed end of said instrument.
References (Iited in the file of this patent UNITED STATES PATENTS 652,999 Denis July 3, 1900 1,476,233 Zell Dec. 4, 1923 1,924,968 Weichlen Aug. 29, 1933 2,554,241 Corper May 22, 1951 2,602,042 Abbott July 1, 1952 FOREIGN PATENTS 349,283 Germany Feb. 28, 1922 378,198 Great Britain Aug. 11, 1932 OTHER REFERENCES Drug Trade News, vol. 27, No. 22, page 55, Oct. 27, 1952.
Claims (1)
1. THE METHOD FOR PREPARING MEDICINAL MATERIALS IN SUITABLE FORM FOR INTRODUCTION IN A DRY, SOLID STATE INTO THE ANIMAL ECONOMY WHICH INCLUDES: ADMIXING A QUANTITATIVE AMOUNT OF THE DESIRED MEDICINAL MATERIAL WITH AN AQUEOUS METHYL CELLULOSE SOLUTION; DIPPING THE POINTED END OF A STERILE NEDDLE-LIKE INSTRUMENT INTO SAID ADMIXTURE; REMOVING SAID INSTRUMENT FROM SAID ADMIXTURE; AND ALLOWING THE PORTION OF THE ADMIXTURE WHICH HAS ADHERERED TO SAID INSTRUMENT TO DRY INTO A HARD FILM.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US394496A US2779332A (en) | 1953-11-25 | 1953-11-25 | Procedure for intracorporal intra-and subcutaneous test, therapy, immunization, vaccination, and drug adminstration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US394496A US2779332A (en) | 1953-11-25 | 1953-11-25 | Procedure for intracorporal intra-and subcutaneous test, therapy, immunization, vaccination, and drug adminstration |
Publications (1)
Publication Number | Publication Date |
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US2779332A true US2779332A (en) | 1957-01-29 |
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Application Number | Title | Priority Date | Filing Date |
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US394496A Expired - Lifetime US2779332A (en) | 1953-11-25 | 1953-11-25 | Procedure for intracorporal intra-and subcutaneous test, therapy, immunization, vaccination, and drug adminstration |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3194237A (en) * | 1962-10-05 | 1965-07-13 | American Home Prod | Pronged vaccinating and testing needle |
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US652999A (en) * | 1899-01-31 | 1900-07-03 | Louis A Denis | Vaccinating instrument. |
DE349283C (en) * | 1918-07-30 | 1922-02-28 | Julius Freudenberger | Process for killing bacteria and sterilizing objects |
US1476233A (en) * | 1920-08-23 | 1923-12-04 | Zellstraub Lab Inc | Biological product |
GB378198A (en) * | 1931-07-31 | 1932-08-11 | Paul Anselm | Process for the conservation of the activity of a vaccine in a fatty and antiseptic medium |
US1924968A (en) * | 1926-12-24 | 1933-08-29 | Weichlein Werner | Process for the manufacture of vaccines |
US2554241A (en) * | 1944-06-03 | 1951-05-22 | Nat Jewish Hospital | Inert transdermal adhesive for use in making skin tests of specific biological reactions for various diseases |
US2602042A (en) * | 1947-08-16 | 1952-07-01 | Inez M Abbott | Processing methyl cellulose and the products thereof |
-
1953
- 1953-11-25 US US394496A patent/US2779332A/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US652999A (en) * | 1899-01-31 | 1900-07-03 | Louis A Denis | Vaccinating instrument. |
DE349283C (en) * | 1918-07-30 | 1922-02-28 | Julius Freudenberger | Process for killing bacteria and sterilizing objects |
US1476233A (en) * | 1920-08-23 | 1923-12-04 | Zellstraub Lab Inc | Biological product |
US1924968A (en) * | 1926-12-24 | 1933-08-29 | Weichlein Werner | Process for the manufacture of vaccines |
GB378198A (en) * | 1931-07-31 | 1932-08-11 | Paul Anselm | Process for the conservation of the activity of a vaccine in a fatty and antiseptic medium |
US2554241A (en) * | 1944-06-03 | 1951-05-22 | Nat Jewish Hospital | Inert transdermal adhesive for use in making skin tests of specific biological reactions for various diseases |
US2602042A (en) * | 1947-08-16 | 1952-07-01 | Inez M Abbott | Processing methyl cellulose and the products thereof |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3194237A (en) * | 1962-10-05 | 1965-07-13 | American Home Prod | Pronged vaccinating and testing needle |
US3470011A (en) * | 1967-02-07 | 1969-09-30 | American Cyanamid Co | Process for applying liquid biologicals to applicators for intracutaneous injection |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
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