US2663461A - Container for pharmaceuticals and the like - Google Patents

Container for pharmaceuticals and the like Download PDF

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US2663461A
US2663461A US10237249A US2663461A US 2663461 A US2663461 A US 2663461A US 10237249 A US10237249 A US 10237249A US 2663461 A US2663461 A US 2663461A
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material
capsule
lips
sealing
container
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Frank E Brown
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FREDERICK M TURNBULL
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FREDERICK M TURNBULL
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06Ampoules or carpules
    • A61J1/067Flexible ampoules, the contents of which are expelled by squeezing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D35/00Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
    • B65D35/44Closures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00Closures with filling and discharging, or with discharging, devices
    • B65D47/04Closures with discharging devices other than pumps
    • B65D47/20Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2031Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure the element being formed by a slit, narrow opening or constrictable spout, the size of the outlet passage being able to be varied by increasing or decreasing the pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/40Packages formed by enclosing successive articles, or increments of material, in webs, e.g. folded or tubular webs, or by subdividing tubes filled with liquid, semi-liquid, or plastic materials
    • B65D75/44Individual packages cut from webs or tubes
    • B65D75/48Individual packages cut from webs or tubes containing liquids, semiliquids, or pastes, e.g. cushion-shaped packages
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52Details
    • B65D75/58Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5805Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness
    • B65D75/5811Opening or contents-removing devices added or incorporated during package manufacture for tearing a side strip parallel and next to the edge, e.g. by means of a line of weakness and defining, after tearing, a small dispensing spout, a small orifice or the like
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S206/00Special receptacle or package
    • Y10S206/82Separable, striplike plural articles

Description

F. E BROWN Dec. 22, 1953 CONTAINER FOR PHARMACEUTICALS AND THE LIKE Filed June 30, 1949 Patented Dec. 22, 1953 UNITED STATES PATENT OFFICE CONTAINER FOR PHARMACEUTICALS AND THE LIKE Application June 30, 1949, Serial No. 102,372

6 Claims.

This invention relates to a dispensing-type capsule or container, and more particularly to a dispensing-type capsule for dispensing individual or metered quantities of a contained ma terial.

The invention is particularly well suited to a single-dosage, single-use, throw-away type unit for discharging a single or metered dosage of the contained material. This contained material may be, for example, a pharmaceutical preparation, such as any of the various medicaments, dentifrices, shampoos, disinfectants, deodorants. suntan lotions, ointments, dermatological preparations, etc., or materials for other uses, such as incremental portions of paints or pigments therefor, oils or greases, chemicals, edible products, fiavorings or seasonings, glues, etc. to specify only a few of the various classes of contained material. Additionally, these contained materials may be liquids, jellies, creams, pastes, semi-fluids, semi-solids, solids in tablet or subdivided form, powders, suspensions, emulsions, etc.

The term single-dosage is used herein in a broad sense as referring to any contained material present in a predetermined or metered amount to be substantially totally expelled for a single-use purpose. While the provision of a single-dosage dispenser is among the more important objects of the invention, the invention can also be used for multiple-dosage storage of contained material which is to be hermetically, bacterially or sanitarily sealed prior to expelling the first dosage.

There has long been needed a single-dosage container for pharmaceuticals which will not spread infection and which will expel a metered dosage. Currently, many medicaments, dentifrices, etc. are sold in multi-dosage tubes having a dispensing neck which can come into contact with infected portions of the body or with some applicator (swab, toothbrush or other pharmaceutical-transferring means) which has previously been in contact with such infected portions or with germs, bacteria, etc. from the same or a different patient or user or from some other source. This contaminates the neck of the tube and contaminates the subsequently-expelled dosage to reinfect the same person or freshly infect another person, even though the dispensed material is in itself bactericidal. The medical profession experiences such contamination in conjunction with treatment of the eye, ear, nose, lip, mouth or other orifices of the body. The public in general experiences such contamination in similar treatments and also in the dispensing of toothpaste which is commonly wiped off the mouth of the tube with the toothbrusha procedure which may reinfect the user or pass infection amongst members of the family. In this latter respect, the family-size toothpaste container is one of the worst oifenders in spreading mouth infections, such as Vincents angina.

The present invention provides a cheap and effective container for pharmaceuticals and the like which is effectively sealed until used, the seal being easily ruptured as a part of the material-expelling operation and without the preceding application of solvents, tearing, cutting, piercing or other mechanical operations.

The invention has among its objects and comprehends in its claims, features and structures as follows:

(A) A container which effectively seals the contained material, from the time of filling to the time of use, against entry of air, moisture, germs, bacteria, etc. yet which provides an applied or tensionally-weak sealing means which is readily rupturable by pressure developed internally of the container as a part of the expelling operation and without using any of the opening expedients mentioned above.

(B) A container which provides a normallycollap-sed discharge opening with side walls lying adjacent and substantially in contact with each other and which side walls separate at the discharge opening upon advancement of the contained material toward the opening, this advancement tending to spread the walls, break a tensionally-weak seal thereadjacent and form the discharge opening into an orifice of a size and shape desired for expelling the contained material.

(C) A container in which a discharge opening is hermetically and bacterially sealed by a mass of container-adhering sealing material more readily rupturable than the container and rupturable solely by increase in internal pressure in the container induced usually by squeezing thereof.

(D) A container formed of one of the wellknown plastic materials and sealed by a plastic material of lesser tensional strength than the container itself.

(E) Such a container formed of a plastic material and sealed by the same type of plastic material but of somewhat lower molecular weight or sealed by some other type of plastic material.

(F) A container formed of or coated with a plastic material which is an effective barrier for vapors, such as the vapors of essential oils that may be present in the contained material.

(G) A container which can be economically formed and which has sealed portions spaced from each other to define an expelling passage for the contai ed material.

(H) A series of containers temporarily adhered in in-line relationship for ease in handling and marketing, the end container of the series being readily separable from its neighbor at the time or intended use.

(I) A method of making any of the containers noted above which is cheap and economical and which insures that the contained material shall be adequately sealed until the time of use, at which time the seal is broken by tensional rupture of the sealing medium. I

Other objects and advantages-of the invention will be evident to those skilled in the art from the following description of exemplary embodiments:

Referring to the drawing:

Fig. 1 illustrates successive steps inv the manuiacture of the preferred type pf capsule in views A-E, inclusive;

Fig. 2 illustrates a final or sealing operation Fig. 3 is an enlarged elevational view of the preferred form of capsule;

Fig. i is a side view of same, taken in the direction of arrow i of Fig. 31; V

Fig. 5 is a vertical sectional view taken along the line of Fig. 3;

Fig. 6 illustratesa modification in which coated stock is employed;

Fig. 7 illustrates a further modification in which the container or capsule is coated after being sealed;

Fig. 8 illustrates a series of adhering capsules, arranged in one manner;

Fig. 9 illustrates a series of adhering capsules, arranged in another manner; and

Fig. 10 is a perspective view illustrating the manner of use of the invention.

.The invention can best be described by the sequence of manufacture views of Figs. 1 and 2, taken with the enlarged. views of Figs. 3-5. It will be understood, however, that the capsules of the latter figures can be formed by sequences other than those illustrated in Figs. 1 and 2 and that these sequences are illustrative of a preferred manner of forming the capsule from tubular-stock thermoplastic material. Similar methods starting with a tubular material formed by heat sealing an edge of a folded sheet or by heat sealing the edges of two sheets of thermoplastic material will be obviou to those skilled in the art from the illustrated example.

View A of Fig. 1 illustrates a pre-cut length of tubular-stock material. For purpose of illustration and example, the length of tubular-stock material, indicated at it, is formed of a pliable but substantially nonstretchable thermoplastic material which can be sealed by heat, applied by a hot element or by induction means. Examples of preferred materials will be later given.

View B of Fig. 1 illustrates the operation of heat-sealing the rear end of the tube It by pressing the adjacent side walls together and applying heat to form a closed or sealed end H of the completed container or capsule [2, shown in Fig. 3. This operation provides within a body portion is of the capsule a storage zone It.

The next operation, illustrated in view C, of Fig. 1, involves partial filling of the container or capsule and substantially complete filling of the storage zone M by the material l5 to be dispensed, care being exercised to deposit this material in the bottom of the container or capsule and care being exercised to avoid coating the upper inner walls of the tubular stock with such material.

The next step is to heat-seal side portions of the tubular stock at a position beyond the mate rial i5 by squeezing together and applying heat to side zones of the tubular stock, preferably followed by trimming, as suggested in views D and E of Fig. 1. The preferred procedure is to collapse or flatten the open end of the tubular stock and apply heat in an irregular zone, suggcstedinviewD as including side bands ii and i8 and intersecting tip bands 59 and 28. If desired, the walls may be sealed not only in these bands but also at positions beyond or outside thereof.

The following step, illustrated in view E of Fig. -1, involves trimming away the excess material outside the bands ii and iii and cutting along the line AA, substantially at the base of the tip bands is and ill, to present cleanlytrimmed'edges or lips '22 of the side walls and 23, best illustrated in Fig. 5.

When thus trimmed, the capsule l2 provides edge-sealed side portions 25 and substantial- 1y coextensive with or formed'ii'orn the side bands I? and 8. The side portions and 2% are spaced from each other to provide an expelling passage 27 opening on the storage zone i l and extending to the .lips 22. it is preferred, although not absolutely essential, that this passage converge toward the lips 22 in the plane of the .paper in Fig. 3. Likewise, the walls 23 and 24 and the intervening passage 2"! will usually converge toward the lips 22 a plane transverse to such plane, namely, in the plane of the paper in Fig. 4, this being usually caused by the larger diameter of the filled body portion Correspondingly, progressive sections taken transversely through a neckportion of the capsule i2 will be substantially oval in shape, the minor axis of the oval progressively decreasing toward the lips 22 and the major axis preferably decreasing in that section of the neck portion 22 which is closest and integral with the body portion l3. The remaining section of the expelling passage 2?, closer to the lips 22, may desirably be of uniform width, measured along such major axis to shape the contained material is prepa ra-tory to. ejection.

It is a feature of the invention to provide an expelling passage terminating at or co-.'nunieating with a flattened portion of the-container forming lips such as the lips 22. Such lips normally lie in contact with or very close to each other in side-by-side relationship and form a potential discharge orifice the being spreadable by increase in pressure within the container or capsule to form a discharge orifice, usually of substantially oval shape, through which the material 15 may be expelled. in other words, the lips 22 normally lie adjacent each other but are spreadable by increase in internal pressure, set up by squeezing the container Or capsule, to separate and form the discharge orifice. Likewise, the material lE, forced along the ex elliug passage 2'? by the external pressure, will tend to swell or separate the central portions of the walls 23 and 2 5, thus creating a force tending to separate the lips 22. This force is relied upon to rupture a seal adjacent the lips 22.

The potential discharge orifice SR2 and the lip 22 are sealed by a pressure-rupturable sealing means which serves to join the lips and hold them close to each other. In accordance with the present invention, the sealing means should have a tensile strength less than that of the container or capsule to be rupturable by the aforesaid force or internal pressure induced by squeezing. The preferred pressure-rupturable sealing means comprises a mass of a sealing substance applied to the exterior of the container or capsule, preferably immediately adjacent the lips 2?. to extend across these lips in sealing relationship. Thesealing substance 33 should also preferably extend at least a small distance along the walls 23 and 25 to increase the area of contact. A portion of the sealing substance should extend beyond the extremities of the lips 22 to provide a hermetic and bacterial seal for the capsule and its contained material.

The preferred manner of forming the mass of sealing substance 33 is to contact the lips 22 while substantially closed. with a semi-fluid sea1- ing substance. Fig. 2 shows one way of accomplishing this, namely, by inverting the capsule, dipping the lips 22 momentarily in a body of molten sealing substance til held in a container 35, raising the capsule with a glob of the sealing substance adhering to the lips and cooling the substance to form the mass of sealing substance 33, shown in Figs. 25.

The sealing substance should preferably be in a rather viscous state, the vi cosity determining in part the amount of material picked up from the larger mass of the sealing substance. Additionally, the sealing substance may be any material that will bond to and seal the lips 22, yet which will not be meltable in storage or in use, preferably a substance which is not water soluble. Additionally, the mass of sealing substance should be of lower tensile strength than the capsule or container itself, whereby squeezinginduced internal pressure will cause rupture only of the mass of sealing substance 33, this mass ordinarily separating under tension at or near the plane of contact or adjacency of the lips 22, leaving a portion of the mass of sealing substance adhering to each of the side walls 23 and E i.

In many instances, it is preferable to leave a minute air space in the expelling passage 2! ahead of the material l5, as suggested in Fig. 3. This is particularly true when the material is a paste-like material, such as toothpaste. The entrapped air or other gas will not harden the surface of the paste-like material, becoming soon saturated with volatile components thereof. Additionally, the entrapped serves the very useful purpose of applying the spreading force to the side Walls 23, 22 used to rupture the seal and separate the lips 22. This means that the gas will open th discharge orifice prior to the time that the paste-like material reaches this orifice, thereby preventing any initial surge of the paste-like material through the orifice upon rupture of the sealing substance.

In the embodiment of the invention thus far described, the body material is preferably a resin-type thermoplastic material, as is also the sealing substance, the latter having different physical properties as compared with th former. The particular thermoplastic material used will depend in part on the product to be marketed in the capsule. If this product contains essential oils, this may determine the selection of the body material if the escape of vapors of such oils is to be avoided. By way of example, two types of body material, particularly advantageous in the present invention will be described, together with appropriate sealing substances for therewith.

If the product or contained material is .devoid of volatile materials, such as essential oils, or if some escape thereof can be tolerated, a very satisfactory thermoplastic body material is a highly polymerized ethylene, such as polyethylene or polyethylene resin. Such roducts are currently manufactured, in several commercial grades, and are essentially linear poly-' mers of ethylene. produced by the direct polymerization of ethylene at high temperatures and high pressure. These materials are character-- ized by low moisture vapor transmission, good chemical resistance, heat scalability, non-toxicity, complete lack of odor and taste, and inherent flexibility even at temperatures below (3 C. The products known as polyethylene grades DYLT or DYNH have been found suitable and have a melting point of about 300-350 F. A similar material, known as polythene can also be used.

In using such materials, the tube Hl may have a wall thickness of about .003-.010", a wall thickness of .005" being quite satisfactory. However, the above materials often will not form satisfactory barriers for the vapors of essential oils, particularly with the small wall thicknesses contemplated. For example, if toothpaste is marketed therein, a faint odor of the flavoring oils can be detected exteriorly of the capsule, even though the discharge orifice 39 is adequately sealed against transmission of such vapors.

In instances where the capsule is to be an adequate barrier against vapors of essential oils or similar vapors, I prefer to use a material known as Saran. This material is the best known vapor barrier, next to lead, and is a pliable but substantially nonstretchable thermoplastic resin having the functional properties previously enu-v merated and being particularly well suited to the present invention. Saran is a co-polymer of vinylidene chloride and is available in severalv grades. Grade S-51'7 is cited, by way, of example, as suitable, although other formulations of this product can be successfully employed as the body material. This product can be readily heat sealed at about 290310 F. and is readily extrudable, temperatures of about l50--.'550" F. being employed in converting the plastic from its powdered condition preparatory to extrusion. The preferred wall thicknesses of Saran are substantially less than those preferred for the polyethylene type material, being in the neighborhood of about .002.005" and thus forming an extremely pliable body material.

The sealing substance 33 may be any pressurerupturable material having the properties outlined earlier. I prefer to use a thermoplastic resin as the sealing substance, selecting the material to be of lower tensile strength than the body material. Often, the sealing substance can be of the same type as the body substance but of lower molecular weight and lower melting point. By way of example, if the body material is polyethylene DYLT or DYNH, the sealing substance may be a lower-molecular weight polyethylene, such as polyethylene DXL-fl having a melting point of about 250 F., sumciently below the melting point of the body ma: terial so that contact of the sealing substance with the body material will not melt the latter or induce a temperature sufficient to fuse the lips 22 directly together.

If Saran is employed as the body material, a lower-molecular weight Saran may be eme 7 prcyedas thesea'ling substance, typically a prod uct having an extrusion temperature of, around 200 F. Alternatively, a suitable polyethylene sealingsub'stance can be employed with a Saran body material if the former is of sufuciently low molecular weight to have a tensile strength and a rlfrelting point respectively less than the tensile strength and bonding temperature of the latter.

Both polyethylene and Saran have nonporous surfaces to which the usual adhesives will notstick. Bythe same token, the resin-type mass ofsealing substance 33 will not be permanently, integrally or tightly bonded or adhered to the body material, the bonding or adhesion with which the invention is concerned, when employing a s1 tic sealing substance against a plastic b y ate'rial, being looser and representing an adhesion or bonding arising more from surface irregularities of 'thebo'd'y material. There are minor mechanical irregularities in the exterior surfaces of the lips and these are filled by the sea -i'ig substa-nce, tending to prevent withdrawal of the cap-like mass of sealing substance during transportation and normal handling. Additional- 1y, he sealing substance encircles or encompasses the lips as 'a ring to form a mechanical lock, particularly if, as is desirable, a portion of the mass of sealing substance extends in contact with the sidewalls 23 and 2'4 for a small distance from the edges of the lips.

In practice, the mass of sealing substances can usuallybe pulled from the lips in cap-like form a fingernailor blunt knife blade. However, the dhesion is sufiicient to hold the sealing subs't a tie in place during all normal handling of the eat H e When pressure is applied to expel the contents, the mass of sealing substance breaks under tension in substantially the plane ofthe potential discharge orifice 36, leaving one 'portibn of the mass of sealing substance still adher to ene'of the side walls and another portion still "adhering to the other side wall.

It is not essential that the body portion I3 be frnied'enti'rely of the aforesaid thermoplastic als. Thus, in Fig. 6, I have shown a laminated construction in which the tubular stdck initially comprises a base material 31 with interior and exterior coatings 38 and 39 of a suit-'- able thermoplastic resin, such as Saran or f polyethylene. Coatings of such materials can be applied to any number of flexible base materials, such as papen cloth, other thermoplastic ma er'ials. etc. Any such flexible material can be employed as the base material 31. Merely by Way of example, the base material 3'! may be a polyethylene material and the coatings 38 and 39 may be a Saran material to increase the barrier against vapors. Alternatively, Saran or polyethylene may be coated over paper, cloth, or other flexible but substantially nonstretchable material as the base material 37. The previously-described sealing substance 33 can be applied to, any "such laminated body portion l3 and capan otherwise be made by the same steps as usly outlined. itionally, it is not invariably necessary to use both internal and external coatings when employing a laminated body portion iii. For exan 1' e, merely a very thin coating of Saran 21 led interiorly or exteriorly will often sumce "to provide a sufficient vapor barrier even if the base material 31 is quite permeable to vapors. With only an exterior coating of the base materm '37, the latter may be in direct contact with the contained material, in which event it should 8. be relatively inert thereto. if the base material 37 is coated'only on its inner side, it will be made of a material forming a satisfactory exterior for the capsule. Most any such base material will provide a satisfactory base for the sealing substance 33.

Normally, the sealing substance 33 will bridge across the closed lips. However, Whether the sealing "substance is applied by dipping or by otherwise applying a small mass of the fluid sealing substance to the lips, a portion of the sealing substance may enter the discharge orifice, particularly if the lips are not entirely in surface contact. Any of the sealing substance which thus enters the potential discharge orifice will act as an additional seal and yet will not interfere with the pressural breaking of the seal as previously described.

Instead of starting with a coated base material, as in Fig. 6, it is possible to coat exteriorly a finished capsule, made as suggested in Figs. 1-5, to decrease its vapor permeability or to form an additional protective coating thereon. This is suggested in Fig. '7 which shows, greatly enlarged, the discharge end of a capsule, formed as in Fig. 5, the complete capsule being dipped into a coating solution to form an external film 35' covering the entire capsule, with the exception of the mass of sealing substances 33. It is usually not desirable to coat the latter as the coating itself would tend to reinforce and to prevent rupture of the seal when the pressure inside the capsule is increased by squeezing thereof. The coating solution may be molten Saran of lower melting point than the base material 31 or it may be Saran or other thermoplastic resin in solution, the solvent readily vaporizing to leave the coating 39'. A solution of Saran in methylethylketone will usually befound satisfactory and will apply a thin vapor-barrier film to a capsule formed of polyethylene or other plastic material.

A plurality of the containers or capsules l2 may be marketed while packed in a suitable box or they may be dispensed one at a time from any suitable dispenser, whether or not coin operated. However, it is often preferable to market the containers or capsules H2 in adhering and in-line condition, so that one unit at a time can be severed from the series, the end unit being graspable between the fingers and severed from the remaining series without rupture of any of the sea s.

Fig. 3 shows a plurality of the capsules i2 joined or adhered side by side in a common plane. This is facilitated by the shape of the capsules previously described as the end portion Ii and the sid portions 25, 25 provide adhering zones in the form of tips 30 extending outwardly of the body portion 13, these tips being suitably connected to corresponding tips of an adjacent capsule. In Fig. 8, small masses M of any suitable adhering substance locally join the adhering zones of adjacent capsules as b bridging or adhering the correspondingtips All; thereof. If desired, the masses 4! maybe small portions of the same tensionally-Weak substance as was used to seal the capsules, e. g., "polyethylene grade DXL- l, men tioned above. Instead of adhering the capsules side by side at their edges or tips, the capsules can be stacked face to face and a small mass of such adhering substance placed between contiguous side walls or faces of the body portions of adjacent capsules.

Fig. 9 shows another manner Of temporarily adhering a serics of the capsules by use of small masses #2 of an adhering substance joining adboring zones of adjacent capsules, e. g., joining the mass of sealing substance 33 of one capsule with the opposite end of the next capsule. In using such end-to-end joining, the adhering substance should preferably be merely temporarily connected to the end of the next capsule, to separate therefrom without rupture of the sealing substance, or the adhering substance should be of even less tensional strength than the sealing substance 83, either because of a lesser thickness or size or because of being made of a substance having less tensile strength than that of the sealing substance. In other words, it is preferable that a capsule can be severed from the series without breaking the seal of the severed or adjacent capsule.

In use, a capsule is severed from the series by a slight pull. While still sealed, it is placedin the locale of the desired expulson of the contents, e. g., above a toothbrush, By squeezing the walls of the body portion is between the fingers, as suggested in Fig. 10, the internal pressure will be built up and the contents will be advanced along the expulsion passage 2'8, both actions tending to spread the side walls 23, 2 to break the seal formed by the mass 33 of the sealing substance. Ihe squeezing is preferably progressive, starting adjacent the rear end of the capsule and advancing toward the expelling end. This is easily accomplished by a rolling of the finger tips along the capsule to induce the squeezing. If the capsule is small, its entire contents may be expelled by a single squeeze but if the capsule is larger or the users fingers smaller, it may require a second or advanced grip on the capsule to expel its contents.

The orifice 3t preferably opens into oval shape when expelling substances such as toothpaste, thus applying a flat layer of the paste to the toothbrush.

I am aware that various changes and modifications can be made without departing from the spirit of the invention and I desire that the invention as claimed herein be interpreted as broadly as is consistent with the advance made.

I claim:

1. A dispensing-type capsule for containing and dispensing a dosage of a contained material, said capsule including: a hollow body portion providing a storage zone adapted to contain said material, said body portion having closed end and an expelling end; a neck portion integral with said expelling end of said body and comprising a pair of walls substantially collapsed at their ends to form a pair of lips lying adjacent each other but spreadable to form a discharge orifice for such material, said walls converging toward each other when said lips are adjacent each other to form a material-receiving passage opening on said storage zone, the plane toward which said walls converge being at right angles to the plane of said lips when adjacent each other, and said material-receiving passage also converging toward said lips in the plane of said lips, said body and neck portions being formed of tubularstocl: pliable material which when squeezed will advance said material along said passage toward said lips to impose a force on said walls tending to separate said lips and enlarge said discharge orifice; said necl: portion being provided by sealed side portions of said tubular stock, said closed end of said body portion comprising sealed end walls of said tubular-stock pliable material, said sealed side portions and said sealed end walls resisting rupture when said body portion is squeezed to create said rupturing force; and a pressurerupturabl'e sealing substance joining and sealing said lips and holding same close to each other, said sealing substance having a tensile strength less than said body and neck portions to rupture by said force.

2. A dispensing-type capsule for dispensing a contained material, said capsule comprising: a container body of tubular=stock, pliable, thermoplastic material having one end ciosed by a nonrupturable seal and containing the m terial to be dispensed, the other end having opposite side portions sealed at a position extending beyond the material filling, said side portions being spaced from each other to provide a potential expelling passage terminating in a pair of lips adjacent to each other but spreadable on squeezing-induced pressure inside the capsule, the walls of said passage converging toward the plane of the adjacent lips and also toward a plane at right angles to said plane, and a mass of sealing substance surrounding and adhering to said lips and of such tensile strength as to be rupturable on squeezinginduced pressure inside the capsule.

3. A capsule as defined in claim 2, in which said sealing substance is a thermoplastic material oi the same type as, but of lower molecular weight than, the thermoplastic material forming the container body.

i. A capsule as defined in claim 2, in which a small body of gas is provided between the material filling and sealing substance, said gas being compressed on squeezing to rupture the sealing sub stance and thereby spreading the lips prior to the time the material filling reaches the lips.

5. The method of making a dispensing-type capsule comprising: heat-sealing an end of a tubular-stock, pliable, thermoplastic material to close said ends and provide a container; partially filling said container with the material to be dispensed; transversely heat-sealing the open end of the tubular stock at a position spaced from said material and heat-sealing spaced opposite side portions thereof from said transverse seal toward said material leaving the space there'between unsealed and trimming said transversely heat-sealed previously open end to provide normally-adjacent lips at the terminus of the expelling passage between said said portions; and sealing the filled container by contacting said lips with a fluid sealing substance to provide a mass of said substance adhering to and closing the lips but of such tensile strength as to be rupturable on squeezingeinduced pressure inside the capsule.

6. A dispensing-type capsule for containing and dispensmg a dosage of a contained material, said capsule including: a hollow body portion providing a storage zone adapted to contain said material, said body portion having a closed end and an expelling end; a neck portion integral with said expelling end of said body and comprising a pair of walls substantially collapsed at their ends to form a pair or" lips lying in mutual contact but spreadable to form a discharge orifice for such material, said body and neck portions being formed of tubular-stock pliable material which when squeezed will advance said material along said passage toward said lips to impose a force on said walls tending to separate said lips and enlarge said discharge orifice; said walls being sealed together in face-to-face relation on opposite sides of said neck portion with the portion therebetween being unsealed and de ning said discharge orifice; said discharge orifice being of 11 substantially less transverse dimension than said. body portion whereby said lips 'ar'e'relati'vlyshort compared to the'diameter of said body portion; and a'pressure -rupturable sealing substalnce joining and sealing said lipsand' holding'saino close to each other, said sealing substance "having'a tensile strength less than. said'bodyanq neck portions to rupture by said force.

" ROWN- References Cited in tho file of this patent UNITED s rATEs PATEKNTVSI Number Name Date.

1,266,413 Crump. Ma 14, 191.8 1,592,584. Viegelmann July 13, 1926 1,607,626 I-I opkinson Nov.'23, 1926 1,742,809, Hoover Jan. 7:, 1930 N ber.

12 Name Date. Thornton June..16, 1935 Westin Jan. 14, 1936 Eden. Oct. 8, 1.940 Ravenscroft.- Apr. 14-, 1942 Scherer -1 June. 30-, 1.942 Vogt; Sept. 29, 1942 Scherer Mar. 19,1946 Cochran June 4, 1946 R065 Nov. 18, 1947 Smith Aug. 3, 19.48 McCldyJ. May110,'1949 Rado Nov. 21, 1950 Scherer- May 15, 1951 FOREIGN PATENTS;

ountry Da e.

US2663461A 1949-06-30 1949-06-30 Container for pharmaceuticals and the like Expired - Lifetime US2663461A (en)

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Application Number Priority Date Filing Date Title
US2663461A US2663461A (en) 1949-06-30 1949-06-30 Container for pharmaceuticals and the like

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US2663461A US2663461A (en) 1949-06-30 1949-06-30 Container for pharmaceuticals and the like
DK509950A DK82541C (en) 1949-06-30 1950-06-14 Single portion cartridge and method for its production.
DE1950B0002641 DE1677219U (en) 1949-06-30 1950-06-24 Capsule for recording and output of materials of all kinds.
DE1950B0005645 DE894609C (en) 1949-06-30 1950-06-24 Capsule for capture and export of materials of all kinds
FR1021004A FR1021004A (en) 1949-06-30 1950-06-27 Container for pharmaceuticals and the like
GB1632450A GB677592A (en) 1949-06-30 1950-06-29 Container for pharmaceuticals and the like
CH294535A CH294535A (en) 1949-06-30 1950-06-29 Packaging, particularly for pharmaceutical products, and method for manufacturing this packaging.

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US2663461A true US2663461A (en) 1953-12-22

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DK (1) DK82541C (en)
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GB (1) GB677592A (en)

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US2802608A (en) * 1954-10-18 1957-08-13 Joseph A Hull Sealed valve dispensing device
US2808926A (en) * 1954-11-10 1957-10-08 Blair M Drake Single dose vial assembly of animal semen
US2861572A (en) * 1957-04-09 1958-11-25 Barnes Hind Lab Inc Medicament dispenser
US2875762A (en) * 1957-09-17 1959-03-03 Jr Carl W Middleton Suppository holder
US2908601A (en) * 1957-05-16 1959-10-13 Unette Corp Manufacture of internal pressure-rupturable seal in thermoplastic tubing
US2944706A (en) * 1957-04-29 1960-07-12 Alfred A Moore Collapsible container and dispensing holder therefor
US2947448A (en) * 1957-07-23 1960-08-02 Duane C Maddux Collapsible tube closure and sealing means
US2962192A (en) * 1958-09-10 1960-11-29 Ivers Lee Co Package for fluent commodities
US2970723A (en) * 1952-12-16 1961-02-07 Flax Valer Manufacture of collapsible tubular container made of flexible materials
US3075528A (en) * 1958-11-26 1963-01-29 Astra Ab Laminated hypodermic syringe ampul
US3152727A (en) * 1961-09-26 1964-10-13 Mayer & Co Inc O Reclosable dispensing package
US3156383A (en) * 1962-04-05 1964-11-10 Maison Ind Tecnico Chimiche Ne Expansible single use dispensing container
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US3178065A (en) * 1963-01-22 1965-04-13 Tubed Chemicals Corp Impermeable collapsible tube
US3184121A (en) * 1963-08-01 1965-05-18 Ivers Lee Co Package with self sealing closure
US3189227A (en) * 1962-12-07 1965-06-15 American Home Prod Fluid dispenser
US3221942A (en) * 1963-07-25 1965-12-07 Polaroid Corp Collapsible fluid container
US3234069A (en) * 1962-10-09 1966-02-08 Szasz Frank Package manufacturing apparatus
US3306567A (en) * 1964-08-20 1967-02-28 Gen Motors Corp Flexible bag for making ice cubes
US3308940A (en) * 1965-08-11 1967-03-14 Jr Theodore Morris Clinical thermometer device
US3338794A (en) * 1964-11-23 1967-08-29 Swift & Co Culturing anaerobic bacteria
US3463358A (en) * 1968-01-11 1969-08-26 Roy F Wenzler Material spreader means
US3523628A (en) * 1968-01-18 1970-08-11 Lee B Colvin Container for cyanoacrylate adhesive
US3652174A (en) * 1968-03-25 1972-03-28 Philip Boone Hermetically-sealed products and related method for cleansing and other uses
US3815794A (en) * 1972-03-02 1974-06-11 R Carlisle Plastic-film containers with self-sealing orifices
US3917120A (en) * 1971-11-11 1975-11-04 Merck Patent Gmbh Single use container for liquid pharmaceutical compositions
US3971376A (en) * 1973-02-26 1976-07-27 Ceskoslovenska Akademie Ved Method and apparatus for introducing fluids into the body
US3989045A (en) * 1972-09-29 1976-11-02 Eck William F Van Hypodermic syringe
US4135883A (en) * 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4159077A (en) * 1976-12-09 1979-06-26 W. R. Grace & Co. Process for closing a flexible container and the container formed thereby
US4252257A (en) * 1978-10-10 1981-02-24 Herzig Albert M Automatic closure for containers having a pinch-off fold
US4328912A (en) * 1978-06-26 1982-05-11 Haggar Theodore Self-contained valved package
US4335815A (en) * 1979-09-26 1982-06-22 Societe Nouvelle De Bouchons Plastiques Flexible package for storing and dispensing liquid or pasty matters
US4384440A (en) * 1979-11-09 1983-05-24 Tetra Pak Developpement Sa Method for the continuous manufacture of packing containers
US4502616A (en) * 1982-01-04 1985-03-05 Health Care Concepts, Inc. Single use vial
US4576284A (en) * 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US4627538A (en) * 1985-03-25 1986-12-09 Kafkis Nick H Vessel closures and method of forming the closures
US4917267A (en) * 1986-11-12 1990-04-17 Laverdure Roland J A Self-closing valve with tamper evident lip seal tab for liquids, pastes or solids
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
US5035348A (en) * 1989-09-01 1991-07-30 Institute Guilfoyle Container having a pressure-rupturable seal for dispensing contents
US5100028A (en) * 1989-09-01 1992-03-31 Institute Guilfoyle Pressure-rupturable container seal having a fluid flow directing shield
US5577636A (en) * 1994-06-10 1996-11-26 Yoshida Kogyo Co., Ltd. Multi-tube container having breakable connections at both ends thereof
FR2738224A1 (en) * 1994-06-10 1997-03-07 Yoshida Kogyo Kk Chained tube package
ES2134099A1 (en) * 1996-05-08 1999-09-16 Laguna Vicente Gomez Stirring blade with container
US6247617B1 (en) 1999-12-13 2001-06-19 Richard Allen Clyde Single use container for dispensing separately housed sterile compositions
US6434913B1 (en) * 2000-09-15 2002-08-20 Thomas Hatch Single-use syringe
US20050257498A1 (en) * 2004-05-18 2005-11-24 Garry Tsaur Tube filling process for liquid filled cotton swabs
US20060042990A1 (en) * 2004-08-24 2006-03-02 Galuten Jerry H Medication kit
WO2006067206A1 (en) * 2004-12-23 2006-06-29 Eurocolori Srl System and method for coloring paints and decorative coatings, and relative actuation device
US20060194710A1 (en) * 2003-02-03 2006-08-31 Reckitt Benckiser N.V. Emanator blister
US20080170814A1 (en) * 2006-12-18 2008-07-17 Cadbury Adams Usa Llc Resealable packaging
US20120312709A1 (en) * 2011-04-12 2012-12-13 Velcera, Inc. Device for storing and dispensing a medicament, and packaging for containing the same
US20130015204A1 (en) * 2009-12-24 2013-01-17 Arash Gol Single-use containers and uses thereof
US20130098864A1 (en) * 2010-07-26 2013-04-25 Lameplast S.P.A. Re-closable container for fluid products, particularly for medical, pharmaceutical and cosmetic products
WO2014011880A1 (en) * 2012-07-12 2014-01-16 Colgate-Palmolive Company Package having unitary body including a break-off cap
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US20150209228A1 (en) * 2014-01-30 2015-07-30 Merle Bruce Squeezable Ampule with Breakable Seal in Nose Bleed Kit
EP2909096A4 (en) * 2012-07-27 2016-06-29 Diana Foster Single use dispenser package
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US9932218B2 (en) 2016-03-04 2018-04-03 BIBO Barmaid LLC Cold beverage dispenser and cutter assembly for cold beverage dispenser
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Cited By (73)

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US2970723A (en) * 1952-12-16 1961-02-07 Flax Valer Manufacture of collapsible tubular container made of flexible materials
US2802608A (en) * 1954-10-18 1957-08-13 Joseph A Hull Sealed valve dispensing device
US2792149A (en) * 1954-10-28 1957-05-14 Joseph M Lutz Collapsible capless tube for toothpaste or the like
US2808926A (en) * 1954-11-10 1957-10-08 Blair M Drake Single dose vial assembly of animal semen
US3171412A (en) * 1956-06-15 1965-03-02 Brann Bernd Container for biological liquids
US2861572A (en) * 1957-04-09 1958-11-25 Barnes Hind Lab Inc Medicament dispenser
US2944706A (en) * 1957-04-29 1960-07-12 Alfred A Moore Collapsible container and dispensing holder therefor
US2908601A (en) * 1957-05-16 1959-10-13 Unette Corp Manufacture of internal pressure-rupturable seal in thermoplastic tubing
US2947448A (en) * 1957-07-23 1960-08-02 Duane C Maddux Collapsible tube closure and sealing means
US2875762A (en) * 1957-09-17 1959-03-03 Jr Carl W Middleton Suppository holder
US2962192A (en) * 1958-09-10 1960-11-29 Ivers Lee Co Package for fluent commodities
US3075528A (en) * 1958-11-26 1963-01-29 Astra Ab Laminated hypodermic syringe ampul
US3152727A (en) * 1961-09-26 1964-10-13 Mayer & Co Inc O Reclosable dispensing package
US3156383A (en) * 1962-04-05 1964-11-10 Maison Ind Tecnico Chimiche Ne Expansible single use dispensing container
US3234069A (en) * 1962-10-09 1966-02-08 Szasz Frank Package manufacturing apparatus
US3189227A (en) * 1962-12-07 1965-06-15 American Home Prod Fluid dispenser
US3178065A (en) * 1963-01-22 1965-04-13 Tubed Chemicals Corp Impermeable collapsible tube
US3221942A (en) * 1963-07-25 1965-12-07 Polaroid Corp Collapsible fluid container
US3184121A (en) * 1963-08-01 1965-05-18 Ivers Lee Co Package with self sealing closure
US3306567A (en) * 1964-08-20 1967-02-28 Gen Motors Corp Flexible bag for making ice cubes
US3338794A (en) * 1964-11-23 1967-08-29 Swift & Co Culturing anaerobic bacteria
US3308940A (en) * 1965-08-11 1967-03-14 Jr Theodore Morris Clinical thermometer device
US3463358A (en) * 1968-01-11 1969-08-26 Roy F Wenzler Material spreader means
US3523628A (en) * 1968-01-18 1970-08-11 Lee B Colvin Container for cyanoacrylate adhesive
US3652174A (en) * 1968-03-25 1972-03-28 Philip Boone Hermetically-sealed products and related method for cleansing and other uses
US3917120A (en) * 1971-11-11 1975-11-04 Merck Patent Gmbh Single use container for liquid pharmaceutical compositions
US3815794A (en) * 1972-03-02 1974-06-11 R Carlisle Plastic-film containers with self-sealing orifices
US3989045A (en) * 1972-09-29 1976-11-02 Eck William F Van Hypodermic syringe
US3971376A (en) * 1973-02-26 1976-07-27 Ceskoslovenska Akademie Ved Method and apparatus for introducing fluids into the body
US4159077A (en) * 1976-12-09 1979-06-26 W. R. Grace & Co. Process for closing a flexible container and the container formed thereby
US4135883A (en) * 1977-08-29 1979-01-23 Bio-Dynamics Inc. Blood analyzer system
US4328912A (en) * 1978-06-26 1982-05-11 Haggar Theodore Self-contained valved package
US4252257A (en) * 1978-10-10 1981-02-24 Herzig Albert M Automatic closure for containers having a pinch-off fold
US4335815A (en) * 1979-09-26 1982-06-22 Societe Nouvelle De Bouchons Plastiques Flexible package for storing and dispensing liquid or pasty matters
US4384440A (en) * 1979-11-09 1983-05-24 Tetra Pak Developpement Sa Method for the continuous manufacture of packing containers
US4502616A (en) * 1982-01-04 1985-03-05 Health Care Concepts, Inc. Single use vial
US4576284A (en) * 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US4627538A (en) * 1985-03-25 1986-12-09 Kafkis Nick H Vessel closures and method of forming the closures
US4917267A (en) * 1986-11-12 1990-04-17 Laverdure Roland J A Self-closing valve with tamper evident lip seal tab for liquids, pastes or solids
US4988016A (en) * 1989-01-30 1991-01-29 James P. Hawkins Self-sealing container
US5035348A (en) * 1989-09-01 1991-07-30 Institute Guilfoyle Container having a pressure-rupturable seal for dispensing contents
US5100028A (en) * 1989-09-01 1992-03-31 Institute Guilfoyle Pressure-rupturable container seal having a fluid flow directing shield
US5577636A (en) * 1994-06-10 1996-11-26 Yoshida Kogyo Co., Ltd. Multi-tube container having breakable connections at both ends thereof
FR2738224A1 (en) * 1994-06-10 1997-03-07 Yoshida Kogyo Kk Chained tube package
ES2134099A1 (en) * 1996-05-08 1999-09-16 Laguna Vicente Gomez Stirring blade with container
US6247617B1 (en) 1999-12-13 2001-06-19 Richard Allen Clyde Single use container for dispensing separately housed sterile compositions
US6434913B1 (en) * 2000-09-15 2002-08-20 Thomas Hatch Single-use syringe
US20060194710A1 (en) * 2003-02-03 2006-08-31 Reckitt Benckiser N.V. Emanator blister
US8273696B2 (en) * 2003-02-03 2012-09-25 Reckitt Benckiser N.V. Emanator blister
US20050257498A1 (en) * 2004-05-18 2005-11-24 Garry Tsaur Tube filling process for liquid filled cotton swabs
US9085378B2 (en) * 2004-05-18 2015-07-21 Unidose Systems, Inc. Tube filling process for liquid filled cotton swabs
US20060042990A1 (en) * 2004-08-24 2006-03-02 Galuten Jerry H Medication kit
WO2006067206A1 (en) * 2004-12-23 2006-06-29 Eurocolori Srl System and method for coloring paints and decorative coatings, and relative actuation device
US8485728B2 (en) 2006-12-18 2013-07-16 Kraft Foods Global, Inc. Resealable packaging
US20080170814A1 (en) * 2006-12-18 2008-07-17 Cadbury Adams Usa Llc Resealable packaging
US20130015204A1 (en) * 2009-12-24 2013-01-17 Arash Gol Single-use containers and uses thereof
US8833576B2 (en) * 2010-07-26 2014-09-16 Lameplast S.P.A. Re-closable container for fluid products, particularly for medical, pharmaceutical and cosmetic products
US20130098864A1 (en) * 2010-07-26 2013-04-25 Lameplast S.P.A. Re-closable container for fluid products, particularly for medical, pharmaceutical and cosmetic products
US20120312709A1 (en) * 2011-04-12 2012-12-13 Velcera, Inc. Device for storing and dispensing a medicament, and packaging for containing the same
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US9908677B2 (en) 2012-07-12 2018-03-06 Colgate-Palmolive Company Package having unitary body including a break-off cap
US9376248B2 (en) 2012-07-12 2016-06-28 Colgate-Palmolive Company Package having unitary body including a break-off cap
WO2014011874A1 (en) * 2012-07-12 2014-01-16 Colgate-Palmolive Company Package having unitary body including a break-off cap
CN104428207B (en) * 2012-07-12 2016-10-19 高露洁-棕榄公司 Comprising a unitary body having the cap disconnection packaging
CN104428206B (en) * 2012-07-12 2017-05-24 高露洁-棕榄公司 Comprising a unitary body having the cap disconnection packaging
EP2909096A4 (en) * 2012-07-27 2016-06-29 Diana Foster Single use dispenser package
US20150209228A1 (en) * 2014-01-30 2015-07-30 Merle Bruce Squeezable Ampule with Breakable Seal in Nose Bleed Kit
US20160376139A1 (en) * 2014-07-22 2016-12-29 BIBO Barmaid LLC Cold beverage dispenser and flexible pouch
US9932218B2 (en) 2016-03-04 2018-04-03 BIBO Barmaid LLC Cold beverage dispenser and cutter assembly for cold beverage dispenser
US20180312309A1 (en) * 2017-04-26 2018-11-01 The Hartz Mountain Corporation Applicator with Breakaway Cap

Also Published As

Publication number Publication date Type
FR1021004A (en) 1953-02-13 grant
GB677592A (en) 1952-08-20 application
DE894609C (en) 1953-10-26 grant
DK82541C (en) 1957-03-25 grant
DE1677219U (en) 1954-06-03 grant

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