US2538793A - Alkamine esters of cyclopentylalkylacetic acids - Google Patents
Alkamine esters of cyclopentylalkylacetic acids Download PDFInfo
- Publication number
- US2538793A US2538793A US43542A US4354248A US2538793A US 2538793 A US2538793 A US 2538793A US 43542 A US43542 A US 43542A US 4354248 A US4354248 A US 4354248A US 2538793 A US2538793 A US 2538793A
- Authority
- US
- United States
- Prior art keywords
- acid
- cyclopentyl
- ether
- ethyl
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title description 36
- 150000002148 esters Chemical class 0.000 title description 24
- 150000007513 acids Chemical class 0.000 title description 8
- 239000000126 substance Substances 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 50
- -1 ethylene, propylene, butylene Chemical group 0.000 description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 24
- 239000000243 solution Substances 0.000 description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 125000000217 alkyl group Chemical group 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 150000003839 salts Chemical class 0.000 description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 5
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- ZGUFUYADDVHERQ-UHFFFAOYSA-N 2-cyclopentyl-4-methylpentanoic acid Chemical compound CC(C)CC(C(O)=O)C1CCCC1 ZGUFUYADDVHERQ-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 125000001302 tertiary amino group Chemical group 0.000 description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- YMDNODNLFSHHCV-UHFFFAOYSA-N 2-chloro-n,n-diethylethanamine Chemical compound CCN(CC)CCCl YMDNODNLFSHHCV-UHFFFAOYSA-N 0.000 description 3
- JRXTXRWPJBGFCP-UHFFFAOYSA-N 2-cyclopentyl-4-methylpentanoyl chloride Chemical compound C1(CCCC1)C(C(=O)Cl)CC(C)C JRXTXRWPJBGFCP-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001242 acetic acid derivatives Chemical class 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- RGPIBWIKEXZOQO-UHFFFAOYSA-N ethyl 2-cyano-3,4-dimethylpentanoate Chemical compound CCOC(=O)C(C#N)C(C)C(C)C RGPIBWIKEXZOQO-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 230000002276 neurotropic effect Effects 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- MLIREBYILWEBDM-UHFFFAOYSA-M 2-cyanoacetate Chemical compound [O-]C(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-M 0.000 description 2
- SYBYTAAJFKOIEJ-UHFFFAOYSA-N 3-Methylbutan-2-one Chemical compound CC(C)C(C)=O SYBYTAAJFKOIEJ-UHFFFAOYSA-N 0.000 description 2
- 241000234282 Allium Species 0.000 description 2
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- IYXGSMUGOJNHAZ-UHFFFAOYSA-N Ethyl malonate Chemical compound CCOC(=O)CC(=O)OCC IYXGSMUGOJNHAZ-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 230000029936 alkylation Effects 0.000 description 2
- 238000005804 alkylation reaction Methods 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 229940124575 antispasmodic agent Drugs 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 2
- IHHACLIGKDGSDA-UHFFFAOYSA-N diethyl 2-cyclopentyl-2-(2-methylpropyl)propanedioate Chemical compound CCOC(=O)C(CC(C)C)(C(=O)OCC)C1CCCC1 IHHACLIGKDGSDA-UHFFFAOYSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- GJRQTCIYDGXPES-UHFFFAOYSA-N iso-butyl acetate Natural products CC(C)COC(C)=O GJRQTCIYDGXPES-UHFFFAOYSA-N 0.000 description 2
- OQAGVSWESNCJJT-UHFFFAOYSA-N isovaleric acid methyl ester Natural products COC(=O)CC(C)C OQAGVSWESNCJJT-UHFFFAOYSA-N 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 2
- 229910003446 platinum oxide Inorganic materials 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229940001593 sodium carbonate Drugs 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 description 1
- HLVFKOKELQSXIQ-UHFFFAOYSA-N 1-bromo-2-methylpropane Chemical compound CC(C)CBr HLVFKOKELQSXIQ-UHFFFAOYSA-N 0.000 description 1
- 125000004807 2-methylethylene group Chemical group [H]C([H])([H])C([H])([*:2])C([H])([H])[*:1] 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 229930003347 Atropine Natural products 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 150000003869 acetamides Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- RDHPKYGYEGBMSE-UHFFFAOYSA-N bromoethane Chemical compound CCBr RDHPKYGYEGBMSE-UHFFFAOYSA-N 0.000 description 1
- 229940043232 butyl acetate Drugs 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- NEHMKBQYUWJMIP-NJFSPNSNSA-N chloro(114C)methane Chemical compound [14CH3]Cl NEHMKBQYUWJMIP-NJFSPNSNSA-N 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 229940125898 compound 5 Drugs 0.000 description 1
- 235000020028 corn beer Nutrition 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000006114 decarboxylation reaction Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- MQRJBSHKWOFOGF-UHFFFAOYSA-L disodium;carbonate;hydrate Chemical compound O.[Na+].[Na+].[O-]C([O-])=O MQRJBSHKWOFOGF-UHFFFAOYSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000010470 malonic ester synthesis reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- VUQUOGPMUUJORT-UHFFFAOYSA-N methyl 4-methylbenzenesulfonate Chemical compound COS(=O)(=O)C1=CC=C(C)C=C1 VUQUOGPMUUJORT-UHFFFAOYSA-N 0.000 description 1
- CZXGXYBOQYQXQD-UHFFFAOYSA-N methyl benzenesulfonate Chemical compound COS(=O)(=O)C1=CC=CC=C1 CZXGXYBOQYQXQD-UHFFFAOYSA-N 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 230000003170 musculotropic effect Effects 0.000 description 1
- SNMVRZFUUCLYTO-UHFFFAOYSA-N n-propyl chloride Chemical compound CCCCl SNMVRZFUUCLYTO-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 125000005936 piperidyl group Chemical group 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229940076133 sodium carbonate monohydrate Drugs 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Definitions
- This invention relates to aminoalkyl esters of cyclopentylalkylacetic acids and to thereapeutically acceptable salts thereof which are useful as antispasmodic agents.
- heterocyclic rings may be classed together as aliphatic tertiary-amino groups; the heterocyclic rings are distinctly non-aromatic in character and can be thought of as two alkyl groups joined together by a divalent bridge such as CH2--, O- or --S.
- the acids which may be used to prepare the salts are those which produce, when combined with the basic esters, salts whose anions are relatively innocuous to the animal organism in therapeutic doses of the salts, so that the beneficial physiological properties inherent in the basic esters are not vitiated by side-efiects ascribable to the anions.
- Appropriate acid addition salts are those derived from mineral acids such as hydrochloric acid, hydrobromic acid, hydriodic acid, and sulfuric acid; and organic acids such as acetic acid, citric acid and tartaric acid.
- the quaternary am- I monium derivatives are obtained by the addition of alkyl or aralkyl esters of inorganic acids or organic sulfonic acids, such as methyl chloride, methyl bromide, methyl iodide, ethyl bromide, propyl chloride, benzyl chloride, benzyl bromide, methyl sulfate, methyl benzenesulfonate, methyl p-toluenesulfonate, etc.
- alkyl or aralkyl esters of inorganic acids or organic sulfonic acids such as methyl chloride, methyl bromide, methyl iodide, ethyl bromide, propyl chloride, benzyl chloride, benzyl bromide, methyl sulfate, methyl benzenesulfonate, methyl p-toluenesulfonate, etc.
- Synthetic antispasmodics usually have both a musculotropic (papaverine-like) action and neurotropic (atropine-like) action. It is desirable that new compounds be introduced which have high neurotropic activity but which lack the characteristic undesirable physiological sideeffects' of ,atropine.
- Our' compounds are distinguished by high neurotropic activity, and, in addition, several members of the series show antihistaminic action.
- the malonic esters are difllcult to prepare because of the steric hindrance of the groups involved, an alternative procedure can be used. This is based on the method of Alexander and Cope [J. Am. Chem. Soc. 66, 886 (1944)], which involves condensation of an aidehyde or ketone with ethyl cyanoacetate and reduction of the resulting ethylenic double bond, all carried out in one step.
- the carbonyl compound used has a structure such that the group R in the resulting substituted cyanoacetic ester, R-CH(CN)-COOC2H5, has 46 carbon atoms.
- the malonic ester or cyanoacetic ester synthesis in a given case depends upon the nature of the alkyl group to be introduced. If the allryl group to be introduced is of the straight chain type or is branched at the end, the malonic ester synthesis is preferred. If the alkyl group is branched, particularly near its point of juncture with the rest of the molecule, the cyanoacetic ester method is preferred.
- a metallic salt of a cyclopentylalltylacetic acid is heated or simply mixed with afitertiaryaminoalkyl halide. In this case the ⁇ 'free basic ester is formed directly.
- Quaternary ammonium salts are prepared by mixing the free basic ester with a lower alkyl or aralkyl ester of a strong inorganic acid or organic sulfonic acid, preferably in an inert organic solvent such as benzene or ether, with or without gentle heating.
- the salt either crystallizes immediately or can be obtained by concentration of the solvent.
- EXAMPLE 1 Diethyl A -cyclopentenyl-isobutlumalonate. To a stirred suspension of 27.6 g. (1.2 m.) of powered sodium in 240 cc. of dry toluene is slowly added 271.6 g. (1.2 m.) of diethyl A -cyclopentenylmalonate. [Noller and Adams, J. Am. Chem. Soc. 48, 2444 (1926).] After nearly all of the sodium has reacted at reflux temperature, 210 g. (1.5 m.) of isobutyl bromide is added dropwise and the mixture refluxed for sixteen hours.
- the hydrochloride of beta-diethylaminoethyl cyclopentyl-isobutylacetate is prepared by passin hydrogen chloride gas into a solution of 18 g. of the free basic ester in absolute ether. A colloidal precipitate forms which crystallizes upon stirring. After filtering, washing with ether and drying, the hydrochloride is obtained, 19.2 g. (94%) M. P. 1185-1195 C.
- Beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate and its hydrochloride (b) Beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate and its hydrochloride.
- Beta-(N- piperidyl)-ethy1 alcohol (19.2 g., 0.148 m.) is dissolved in 100 cc. of dry pyridine and 30 g. (0.148 m.) of cyclopentyl-isobutylacetyl chloride is added, and the mixture is allowed to stand for a few minutes and finally heated on a steam bath for four hours. After cooling the mixture, it is shaken with a solution of 12 g. of sodium carbonate monohydrate in 250 cc. of water and the water layer is separated and extracted with ether.
- the hydrochloride is prepared by passing dry hydrogen chloride gas into a solution of 34 g. (0.115 m.) of ,the free basic-ester in 500 cc. of anhydrous ether. A white, crystalline precipitate forms which is filtered and dried giving about 31 g. (82%) of the hydrochloride of beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate, M. P. 177.5180 C.
- the hydrochloride is prepared in the usual manner by passing dry hydrogen chloride gas through a solution of the basic-ester in anhydrous ether.
- the dry, crystalline, hygroscopic product has the M. P. 59-62 C.
- the hydrochloride is prepared in the usual manner from the basic-ester and dry hydrogen chloride gas in either solution.
- the crude product is recrystallized from methyl isobutyl ketone giving about a 69% yield of hydrochloride, M. P. 141-146 C.
- Beta-diethylaminoethul I cyclopentill-(lmethylbutyl) -acetate and its hudrochloride.
- Cyclopentyl-isobutylacetic acid (11 g., 0.055 m.) is neutralized to phenolphthalein with alcoholic sodium ethoxide, and 7.5 g. (0.055 m.) of betadiethylaminoethyl chloride in 25 cc. of isopropyl alcohol is then added. After standing for several days (or refluxing for several hours), the sodium chloride is removed by filtration, and the volatile 25 solvents are distilled off.
- the basic ester is dissolved in ether, washed with water and extracted with cold dilute hydrochloric acid.
- the acid solution is washed with ether and made basic with sodium carbonate.
- the liberated basic 3O ester is extracted with ether and the ether solu- 40 of 9.5 g. of the basic ester in absolute ether.
- R is an alkyl group of 4-6 carbon atoms, and acid addition and quaternary ammonium salts thereof.
Description
Patented Jan. E8531 UNITED STATES PATENT OFFICE ALKAMINE ESTERS OF CYCLOPENTYL- ALKYLACETIC ACIDS No Drawing. Application August 10, 1948, Serial No. 43,542
9 Claims. 1
This invention relates to aminoalkyl esters of cyclopentylalkylacetic acids and to thereapeutically acceptable salts thereof which are useful as antispasmodic agents. This is a continuationin-part of our copending application, S. N. 643,480, filed January 25, 1946, now abandoned.
These esters have the formula where R is an alkyl group of 4-6 carbon atoms, Y is an'alkylene bridge having at least two carbon atoms separating the oxygen and nitrogen atoms, and N=B is a tertiary-amino group wherein B represents two alkyl groups or the atoms necessary to complete a heterocyclic ring. More specifically Y may be a divalent hydrocarbon radical such as ethylene, propylene, butylene, l-methylethylene, 2-methylethylene or l-methylbutylene; and N=B includes such structures as dimethylamino, ethylmethylamino, diethylamino, dipropylamino, dibutylamino, butylpropylamino, piperidyl, 2-methylpiperidyl, morpholinyl, thiomorpholinyl, betahydroxyethylethylamino, etc. These may be classed together as aliphatic tertiary-amino groups; the heterocyclic rings are distinctly non-aromatic in character and can be thought of as two alkyl groups joined together by a divalent bridge such as CH2--, O- or --S.
These compounds are generally used in the form of water-soluble acid-addition salts or quaternary ammonium derivatives. The acids which may be used to prepare the salts are those which produce, when combined with the basic esters, salts whose anions are relatively innocuous to the animal organism in therapeutic doses of the salts, so that the beneficial physiological properties inherent in the basic esters are not vitiated by side-efiects ascribable to the anions. Appropriate acid addition salts are those derived from mineral acids such as hydrochloric acid, hydrobromic acid, hydriodic acid, and sulfuric acid; and organic acids such as acetic acid, citric acid and tartaric acid. The quaternary am- I monium derivatives are obtained by the addition of alkyl or aralkyl esters of inorganic acids or organic sulfonic acids, such as methyl chloride, methyl bromide, methyl iodide, ethyl bromide, propyl chloride, benzyl chloride, benzyl bromide, methyl sulfate, methyl benzenesulfonate, methyl p-toluenesulfonate, etc.
Synthetic antispasmodics usually have both a musculotropic (papaverine-like) action and neurotropic (atropine-like) action. It is desirable that new compounds be introduced which have high neurotropic activity but which lack the characteristic undesirable physiological sideeffects' of ,atropine.
Our' compounds are distinguished by high neurotropic activity, and, in addition, several members of the series show antihistaminic action.
Our compounds are conveniently prepared by esterification of the corresponding substituted acetic acid, (C5H9)CHR-COOH. The acids themselves are prepared in the following general manner. The sodio derivative of diethyl cyclopentylmalonate, (CsHg)CH(COOC2H5)z, is alkylated with RX, where R is an alkyl group of 4-6 carbons and X is a halogen atom; i. e. chlorine, bromine or iodine. The resulting cyclopentylalkylmalonlc ester,
which involves preparation of the corresponding A-cyclopentenylalkylmalonic ester,
CsH'I-CR-(COOCzHs) 2 by alkylation of diethyl A' -cyclopentenylmalonate, followed by reduction of the double bond. This method is desirable because it provides intermediates for the basic esters of n -cyclopentenylalkylacetic acids which are also valuable compounds.
In some cases where the malonic esters are difllcult to prepare because of the steric hindrance of the groups involved, an alternative procedure can be used. This is based on the method of Alexander and Cope [J. Am. Chem. Soc. 66, 886 (1944)], which involves condensation of an aidehyde or ketone with ethyl cyanoacetate and reduction of the resulting ethylenic double bond, all carried out in one step. In preparing the compounds of the present invention the carbonyl compound used has a structure such that the group R in the resulting substituted cyanoacetic ester, R-CH(CN)-COOC2H5, has 46 carbon atoms. For example, condensation of ethyl cyanoacetate and methyl isopropyl ketone in the presence of ammonium acetate, acetic acid and palladium-on-charcoal in an atmosphere of hydrogen gives ethyl (1,2-dimethylpropyl) -cyanoacetate. The sodio-derivative of the mono-substituted cyanoacetic ester is then alkylated with a cyclopentylhalide to give an ethyl cyclopentylalkylcyanoacetate, (Cal-I9) CR (CN) COOC2H5. This ishydrolyzed and decarboxylated to the corresponding cyclopentylalkylacetic acid,
(CsHs) -CHRCOOH although in lower yield than the hydrolysis and decarboxylation of the corresponding malonic ester. Substituted acetamides appear as byproducts and more drastic conditions of hydrolysis lead to decomposition. Again, in many instances we prefer to prepare first a n -cyclopentenylalkylcyanoacetate by alkylation of a mono-substituted cyanoacetic ester with a A -cyclopentenylhalide, followed by reduction of the ring double bond to a cyclopentylalkylcyanoacetate. Although one step longer, this process provides intermediates for the preparation of valuable basic esters of A -cyclopentenylalkylacetic acids as well as those of the present invention.
The preferred method, the malonic ester or cyanoacetic ester synthesis, in a given case depends upon the nature of the alkyl group to be introduced. If the allryl group to be introduced is of the straight chain type or is branched at the end, the malonic ester synthesis is preferred. If the alkyl group is branched, particularly near its point of juncture with the rest of the molecule, the cyanoacetic ester method is preferred.
The esters of our invention, having the general formula CH9CH(R)COOYN=B as described above, and their acid addition salts, are prepared from the free acid by one of the following methods:
(1) An acid halide 0r anhydride of a cyclopentylalkylacetic acid is reacted with a tertiaryaminoalkanol of the formula HO-YN=B, where Y is an alkylene bridge of at least 2 carbon atoms and N=B is a tertiary-amino group. The reaction is efiected by simple admixture of the two components although heating is generally used to accelerate the reaction. The free basic a 4 ester is obtained by addition of alkali to the reaction mixture. The basic ester may be converted to an acid addition salt by the addition, preferably in non-aqueous medium, of a therapeutically acceptable acid, such as hydrogen chloride in alcoholic solution.
(2) The cyclopentylalkylacetic acid is reacted with a tertiary-aminoalkanol using a mineral acid, such as sulfuric acid, as a catalyst, present in an amount greater than that necessary to neutralize the amino alcohol. The free basic ester and its acid addition salts are obtained as in method 1.
(3) The cyclopentylalkylacetic acid is heated with a tertiary-aminoalkyl halide of the formula ZY-N=B, where Z is halogen (preferably chlorine or bromine) and Y and B have the same meaning as before. The free basic esterand its acid addition salts are obtained as in meth- Od 1.
(4) A metallic salt of a cyclopentylalltylacetic acid is heated or simply mixed with afitertiaryaminoalkyl halide. In this case the }'free basic ester is formed directly.
Quaternary ammonium salts are prepared by mixing the free basic ester with a lower alkyl or aralkyl ester of a strong inorganic acid or organic sulfonic acid, preferably in an inert organic solvent such as benzene or ether, with or without gentle heating. The salt either crystallizes immediately or can be obtained by concentration of the solvent.
EXAMPLE 1 (a) Diethyl A -cyclopentenyl-isobutlumalonate. To a stirred suspension of 27.6 g. (1.2 m.) of powered sodium in 240 cc. of dry toluene is slowly added 271.6 g. (1.2 m.) of diethyl A -cyclopentenylmalonate. [Noller and Adams, J. Am. Chem. Soc. 48, 2444 (1926).] After nearly all of the sodium has reacted at reflux temperature, 210 g. (1.5 m.) of isobutyl bromide is added dropwise and the mixture refluxed for sixteen hours. After cooling, the mixture is neutralized with dilute acetic acid, and the toluene layer is washed with water, dried over anhydrous sodium sulfate and concentrated. The residue is distilled at reduced pressure, first through a Claisen head and then redistilled through an eificient fractionating column. After discarding considerable low boiling material, the product distils at 73 C. (0.02 mm.) giving about 145 g. (46%) of diethyl n -cyclopentenyl-isobutylmalonate,
n =1.4580, d4 =l.0157
(b) Diethyl cycZopentyl-isobutylmalonate.-A
solution of 77.7 g. (0.275 m.) of diethyl A -cycIopentenyl-isobutylmalonate in 30 cc. of alcohol is hydrogenated in the presence of 0.2 g. of Adams platinum oxide catalyst at about 50 pounds pressure. Reduction is complete in about one hour. The product is recovered and distilled at. reduced pressure through a Claisen head, giving about 76 g. (98%) of diethyl cyclopentyl-isobutylmalonate, B. P. 96 C. (0.04 mm.) n =1.4532; d4 =1.0023.
(c) Cyclopentyl-isobutylacetic acid.--A mixture of 1160 g. of diethyl cyclopentyl-isobutylmalonate with a solution of 1000 g. of potassium hydroxide in 2500 cc. of ethanol is heated in a bomb at -150 C. for three hours. After cooling, most of the alcohol is distilled off, water is added to the residue and the whole neutralized with hydrochloric acid. The substituted acetic acid is extracted with ether, and the ether extracts are washed with water and with saturated carbon dioxide ceases to be evolved. Distilla:
tion at reduced pressure gives about 810 g. (97%) of cyclopentyl-isobutylacetic acid, B. P. 79-82 C. (0.08 mm.); n =1.4549; d4 =0.9525.
(d) Beta-diethylaminoethyl cyclOpentyl-isobutylacetate and its hydrochloride.-Cyclopentylisobutylacetic acid (19 g., 0.103 m.) is neutralized to phenolphthalein with alcoholic sodium ethoxide, and 13.9 g. (0.103 m.) of beta-diethylaminoethyl chloride in 40 cc. of isopropyl' alcohol is then added. After standing for several days (or,
refluxing for several hours), the sodium chloride is removed by filtration, and the volatile solvents are distilled off. The basic ester is dissolved in etherfwashed with water and extracted with cold dilute hydrochloric acid. The acid solution is washed with ether and made basic with sodium carbonate. The liberated basic ester is extracted with ether and the ether solution dried over anhydrous sodium sulfate. Distillation of the product at reduced pressure after removal of the ether gives about 20 g. (68%) of beta-diethylaminoethyl cyclopentyl isobutylacetate, B. P. 113 C. (0.03, mm.); n =1.4527; d4 =0.9119.
The hydrochloride of beta-diethylaminoethyl cyclopentyl-isobutylacetate is prepared by passin hydrogen chloride gas into a solution of 18 g. of the free basic ester in absolute ether. A colloidal precipitate forms which crystallizes upon stirring. After filtering, washing with ether and drying, the hydrochloride is obtained, 19.2 g. (94%) M. P. 1185-1195 C.
EXAMPLE 2 (a) Cyclopentyl-isobutylacetyl chloride.-A mixture of 814 g. (4.42 m.) of cyclopentyl-isobutylacetic acid (see Example 1 for preparation of this acid) and 726 cc. of technical grade thionyl chloride is heated on a steam bath until gas ceases to be evolved. The excess thionyl chloride is removed by distillation and the product is distilled from a Claisen flask giving about 866 g. (96.5%) of cyclopentyl-isobutylacetyl chloride, B. P. 99 C. (6 mm), n =1.4608;
(b) Beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate and its hydrochloride.Beta-(N- piperidyl)-ethy1 alcohol (19.2 g., 0.148 m.) is dissolved in 100 cc. of dry pyridine and 30 g. (0.148 m.) of cyclopentyl-isobutylacetyl chloride is added, and the mixture is allowed to stand for a few minutes and finally heated on a steam bath for four hours. After cooling the mixture, it is shaken with a solution of 12 g. of sodium carbonate monohydrate in 250 cc. of water and the water layer is separated and extracted with ether. The combined organic layers are concentrated using a water aspirator and the residue distilled at reduced pressure, giving about 3'7 g. (85%) of beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate, B. P. 106-108 C. (0.02 mm.); n =1.4717; d =0.9600.
The hydrochloride is prepared by passing dry hydrogen chloride gas into a solution of 34 g. (0.115 m.) of ,the free basic-ester in 500 cc. of anhydrous ether. A white, crystalline precipitate forms which is filtered and dried giving about 31 g. (82%) of the hydrochloride of beta-(N-piperidyl) -ethyl cyclopentyl-isobutylacetate, M. P. 177.5180 C.
made basic with sodium hydroxide.
EXAMPLE 3 Beta (N-beta-hydromyethyl-N-ethylamino) ethyl cyclopentyl-isobutylacetate and its hydrochl0ride.To a solution of 13.3 g. (0.1 m.) of N- talline precipitate separates. After several hourson a steam bath, the solvent is removed, the residue dissolved in dilute hydrochloric .acid, and the solution is extracted twice with ether and The product is extracted with ether, washed with saturated sodium chloride solution and .dried over anhydrous sodium sulfate. After removal of the ether, the product is distilled at reduced pressure from a 50 cc. Claisen flask containing a 6fractionating column packed with helices. The main fraction boils at 106" C. (0.012 mm.) giving about 14.2 g. (43%) of beta-(N-beta-hydroxyethyl-N-ethylamino) -ethyl cyclopentyl-isobutylacetate; n =1.4653; d =0.9706.
The hydrochloride is prepared in the usual manner by passing dry hydrogen chloride gas through a solution of the basic-ester in anhydrous ether. The dry, crystalline, hygroscopic product has the M. P. 59-62 C.
EXAMPLE 4 temperature and 50 pounds pressure. Reduction is complete in about one hour. Five such runs are combined, filtered, and the solvent is removed in vacuo on a steam bath. The residue is taken up in ether, washed with water, sodium bicarbonate solution and saturated salt solution, and dried over anhydrous sodium sulfate. After removing the solvent, the product is distilled twice at reduced pressure from a Claisen flask and then through an efficient fractionating column, giving about 143 g. (31%) of nearly colorless ethyl (1,2- dimethylpropyl)-cyanoacetate. B. P. 60 C. (0.12 mm.); n =l.4322; d =0.9552.
(b) Ethyl A cyclopentenyl (LZ-dimethylpropyl)-cyanoacetate.-To 11.5 g. (0.5 m.) of sodium melted under cc. of dry toluene in a 1 liter flask, is slowly added (with vigorous stirring) 91.5 g. (0.5 m.) of ethyl (l,2-dimethylpropyl)- cyanoacetate. When practically all of the sodium has reacted, '77 g. (0.75 m.) of A -cyclopenteny1 chloride is added. Sodium chloride separates and the reaction mixture tests acidic almost immediately. Water is added, the layers separated, and the aqueous layer is extracted with ether. The combined organic layers are washed with saturated sodium chloride solution, and the solvert is removed in vacuo. The residue is distilled at reduced pressure, first from a Claisen flask and then through an efficient fractionating column, giving about 84 g. (67%) of yellow ethyl Li -cyclopentenyl-(1,2-dimethylpropyl) -cyanoacetate, B. P. 84 C. (0.07 mm.); n :1.4709; d =0.9974.
(c) Ethyl cyclopentyl (LZ-dimethylpropybcyanoacetate.A solution of 44.8 g. (0.18 m.) of ethyl A cyclopentenyl (1,2-dimethylpropyD- cyanoacetate in 100 cc. of ethanol is hydrogenated at 50 pounds pressure and 30 C. with 0.2 g. of platinum oxide catalyst. The theoretical amount of hydrogen is absorbed in one hour, and, after filtering, the solvent is removed and the product is distilled at reduced pressure, giving about 40 g. (88.5%) of ethyl cyclopentyl-(1,2-dimethylpropyD-cyanoacetate, B. P. 76 C. (0.01 mm.); n =1.4637; d,= =0.9850.
(d) C'yclopentyl (LZ-dimethylpropyl)-acetic acid.-A mixture 01' 38.7 g. (0.154 m.) or ethyl cyclopentyl (1,2-dimethylpropyl) -cyanoacetate with a solution of 75 g. of potassium hydroxide in 125 cc. of 90% ethanol is heated in a bomb in an oil bath at 160-180 C. for 42 hours. After cooling, the contents of the bomb are diluted with water and a crystalline neutral fraction [cyclopentyl-(1,2-dimethylpropyl) -acetamidel is filtered off. The filtrate is acidified and the acidic oil is extracted with ether, washed three times with water and once with saturated sodium chloride solution containing a little sodium bicarbonate. and finally dried over anhydrous sodium sulfate. After removal of the solvent, the
product is distilled at reduced pressure from a Claisen flask giving about 9.7 g. (32%) of cyclopentyl-(1,2-dimethylpropyl)-acetic acid, B. P. 96 C. (0.06 mm.) n =1.4651; d =0.9668.
(e) Beta-diethylaminoethyl cyclopentyl-(1,2- dimethylpropyl) -acetate and its hydrochloride.- This is prepared from the substituted acetic acid using sodium ethoxide and beta-diethylaminoethyl chloride according to the method shown in Example 1, part (d). Eight and three-tenths grams of the acid results in about 8.4 g. (67%) of beta-diethylaminoethyl cyclopentyl-(1,2-dimethylpropyD-acetate, B. P. 108 C. (0.06 mm.); n =1.4601; d =0.9272.
The hydrochloride is prepared in the usual manner from the basic-ester and dry hydrogen chloride gas in either solution. The crude product is recrystallized from methyl isobutyl ketone giving about a 69% yield of hydrochloride, M. P. 141-146 C.
.EXAMPI5E5 (a) Ethyl A -cyclopentenyl- (l-methylbutyvcyanoacetata-To 18.4 g. (0.8 m.) of sodium melted under 180 cc. of dry toluene in a 1 liter flask, is slowly added (with vigorous stirring) 124 g. (0.8 m.) of ethyl (l-methylbutyD-cyanoacetate [Alexander and Cope, J. Am. Chem. Soc. 66, 886 (1944)]. When practically all of the sodium has reacted, 123 g. (1.2 m.) of A -cyclopentenyl chloride is added. Sodium chloride separates and the reaction mixture tests acidic almost immediately. Water is added, the layers are separated and the aqueous layer is extracted with ether. The organic layer is washed with saturated sodium chloride solution and the solvent is removed at reduced pressure. The product is distilled at reduced pressure, first from a Claisen flask and then through an efllcient column, giving about 125 g. (63%) of ethyl A cyclopentenyll-methylbutyl) cyanoacetate,
B. P. 95 C. (0.2 mm.); n =1.4678; d4 =0.9893. 0 R
(b) Ethyl cyclopentyl- KI-methyZbutyU-cyanoacetate.-A solution of 62.4 g. (0.25 m.) of ethyl A -cyclopentenyl-(l-methylbutyl) cyanoacetate in 100 cc. of ethanol is hydrogenated at room temperature and 50 pounds pressure using 0.2 65
flask, giving about 62 g. (98%) of ethyl cyclo- 70 pentyl-(l-methylbutyl)-cyanoacetate, B. P. 95 C. (0.27 mm.); n =1.4606; d4 =0.9762.
(c) Cyclopentyl- (1 -methylbutyl) -acetic acid.- A mixture of g. of ethyl cyclopentyl- (l-methylbutyl) -cyanoacetate with a solution of 75 5 precipitate separates which is collected, washed with water and dried; weight, 11 g. (35%). This proves to be cyclopentyl-(l-methylbutyl)-acetamide, and a sample when recrystallized from hexane melts at 94-109 C. The basic aqueous b filtrate from above is extracted with ether and then acidified with hydrochloric acid. The product is recovered and purified as in Example 1, part 0 giving about 11 g. (35%) 0t cyclopentyl- (l-methylbutyD-acetic acid. B. P. 96 C. (0.07 15 mm.); n =1.4623; d4 =0.9591.
(d) Beta-diethylaminoethul I cyclopentill-(lmethylbutyl) -acetate and its hudrochloride. Cyclopentyl-isobutylacetic acid (11 g., 0.055 m.) is neutralized to phenolphthalein with alcoholic sodium ethoxide, and 7.5 g. (0.055 m.) of betadiethylaminoethyl chloride in 25 cc. of isopropyl alcohol is then added. After standing for several days (or refluxing for several hours), the sodium chloride is removed by filtration, and the volatile 25 solvents are distilled off. The basic ester is dissolved in ether, washed with water and extracted with cold dilute hydrochloric acid. The acid solution is washed with ether and made basic with sodium carbonate. The liberated basic 3O ester is extracted with ether and the ether solu- 40 of 9.5 g. of the basic ester in absolute ether. A
crystalline precipitate forms which is filtered, washed with ether and dried, giving about 6.9 g. o! the hydrochloride. When recrystallized from methyl isobutyl ketone it melts at 99-103 C. Y
Additional compounds have been made by the methods outlined in the preceding examples and are disclosed in the following tables:
A. M alonates B. P. 0. ([1 mm.) no" usages 11 p 12 TABLE III-Continued Basic Bunk-Continued B P a Com a Y-N=B (D in) cmcmcn omoncm- -cmon we a on H: CHaCHl Onion] n cumin -cmcn 101 o in) CHICK.
. CBQCH. 1 cmcmcn- -cmcn 1100114) 5 CHICK] CHI s........ cmcmcn- -cmcH,N (our!) e CH:
CHECK! 0.-.... CH|(CH|)|- -on.cn 10s a m) omen;
. CHsCH m cmcn-cn- -cmca 108 (0.00)
4 Ha Bl aCHI CIhCHu 11...... cmcmcmcn- -cn.cn,N m (0.35)
HI CHaCH:
CHaCH;
12...---- CHICHCHJCHF CH;C 83 (0. 025) He HaCH:
CHQCH] 1s....... cn cmcncnr- -cn,cm 97 o. 02)
Ha CHsCH:
omen
14....... CHsCHaCHCHg- CH|CH 95 (0. 005) on. n. omenmorpholinyl radicals; and acid addition and Hydro hlorid 5 quaternary ammonium salts thereof. 2. A substance or the group consisting oi basic esters of the formula 0.0110 mas-119.5 0.9204 111 114.5 0.9548
a 019166 101 -1os 0.9193 115 -11s i 0.9402 105 409 0. 9118 103. 5-105 0.9272 141 l46 38 1 5 wherein R is an alkyl group of 4-6 carbon atoms, 31 116 I Y is an alkylene bridge of 2-5 carbon atoms and 0-9176 111-5413 R and R" are lower alkyl groups; and acid addition and quaternary ammonium salts thereof. We claim: I 3. A substance of the group consisting of basic 1. A substance of the group consisting of basic esters of the formula esters of the formula a, a
' /CHr-CH!\ on coo Y N CHC0OY-N\ cm BB is cm-cm wherein R is an alkyl group of 4-6 carbon atoms, Y is an aikylen'e bridge of 2-5 carbon atoms and -N=B is a tertiary-amino group of the class consisting of di-lower-alkylamino, piperidyl and 4. A substance of the group consisting of the formula R omen;
wherein R is an alkyl group of 4-6 carbon atoms, and acid addition and quaternary ammonium salts thereof. 4
5. A substance of the group consisting of betadiethylaminoethyl cyclopentyl n butylacetate of the formula CHzCHa CH-C O CHzCHzN zCHzCHzCH: CHzCH;
and acid addition and quaternary ammonium salts thereof.
6. A substance of the group consisting of beta- (N-piperidyl) -ethyl cyclopentyl isobutylacetate of the formula CHzCHz CH-OOOCHzCH: CH2
HzCHCHs CHZC i and acid addition and quaternary ammonium salts thereof.
7. A substance of the group consisting of betadiethylaminoethyl cyclopentyl (2 ethylbutyl) acetate of the formula CHiCHa CHC O OCHzCHaN CHzCHCHzCHz CHzCH:
CHzCH:
and acid addition and quaternary ammonium salts thereof.
8. A substance of the group consisting of betadiethylaminoethyl cyclopentyl-isobutylacetate of the formula CHzCHa cn-coocmomn k mono-m onion,
and acid addition and quaternary ammonium salts thereof.
9. A substance of the group consisting of betadimethylaminoethyl cyclopentyl sec.-butylacetate of the formula cc-cooomcam ,Homcm cm and acid addition and quaternary ammonium salts thereof.
- ROBERT BRUCE MOFFE'I'I.
CHARLOTTE ANNE HART.
REFERENCES CITED The following references are of record in the file of this patent:
UNITED STATES PATENTS OTHER REFERENCES Yohe et 91.. Chem. Abstracts, vol. 22 (1928), pp. 2147-2148.
Adams, Chem. Abstracts, vol. 23 (1929), page 3543.
Certificate of Correction Patent No. 2,538,793 January 23, 1951 ROBERT BRUCE MOFFETT ET AL. ,It is hereby certified that error appears in the printed specification of the above numbered patent requiring correction as follows:
Column 4, line 35, for -i sobutlymalonate read -v lsobutylmalonate; column 7, line 36, for the word either read ether; columns 11 and 12, Table III, under the heading YN=B, opposite compound 5?, for
OHQHICH CHQCHflOH CH1CH; I read CH| Ha CHa I CHzCHl line 61, opposite compound 13, for 116477 read 116-117; column 13, line 1, after of, second occurrence, insert a cmnpoumd of; column 14, line 14,
for that portion of the formula reading CCCOOCH CH N read and that the said Letters Patent should be read as corrected above, so that the same may conform to the record of the case in the Patent Ofiice.
Signed and sealed this 10th day of April, A. D. 1951.
' THOMAS F. MURPHY, I
I Assistant Oommz'asioner of Patents.
Claims (1)
1. A SUBSTANCE OF THE GROUP CONSISTING OF BASIC ESTERS OF THE FORMULA
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US43542A US2538793A (en) | 1948-08-10 | 1948-08-10 | Alkamine esters of cyclopentylalkylacetic acids |
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US43542A US2538793A (en) | 1948-08-10 | 1948-08-10 | Alkamine esters of cyclopentylalkylacetic acids |
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US43542A Expired - Lifetime US2538793A (en) | 1948-08-10 | 1948-08-10 | Alkamine esters of cyclopentylalkylacetic acids |
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Cited By (6)
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US2691656A (en) * | 1954-10-12 | L-methyl-j-piperidylmethyi | ||
DE961349C (en) * | 1951-07-20 | 1957-04-04 | Sterling Drug Inc | Process for the production of highly effective anticholinergic compounds |
DE1033659B (en) * | 1957-01-24 | 1958-07-10 | Siegfried Ag | Process for the preparation of basic di (cyclopentyl) acetic acid esters |
US2987517A (en) * | 1954-04-20 | 1961-06-06 | Cilag Chemie | Alpha aryl-3-methyl-pentanoic acid-nu-lower alkyl heterocyclic esters |
US3065134A (en) * | 1958-02-19 | 1962-11-20 | Lab Jacques Logeais Soc D Expl | Choleretic hydroxycycloaliphatic acid process |
EP0438837A2 (en) * | 1989-11-30 | 1991-07-31 | MANNESMANN Aktiengesellschaft | Device for blasting the inside of a pipe |
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US1667123A (en) * | 1925-03-02 | 1928-04-24 | Koller Karl | Toy |
US1715052A (en) * | 1928-01-27 | 1929-05-28 | Abbott Lab | Cyclopentyl compound and process of making same |
GB532943A (en) * | 1938-08-05 | 1941-02-04 | Chem Ind Basel | Manufacture of alkamine esters and quaternary salts thereof |
CH220975A (en) * | 1938-08-05 | 1942-04-30 | Chem Ind Basel | Process for the preparation of a basic ester. |
CH221219A (en) * | 1938-08-05 | 1942-05-15 | Chem Ind Basel | Process for the preparation of a basic ester. |
US2351833A (en) * | 1942-04-08 | 1944-06-20 | American Cyanamid Co | N(alkyl,beta-4-morpholylalkyl) aminoalkanol esters |
US2417208A (en) * | 1943-08-04 | 1947-03-11 | Geigy Ag J R | Basic esters of monoalkyl isobutyl acetic acids |
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US1667123A (en) * | 1925-03-02 | 1928-04-24 | Koller Karl | Toy |
US1715052A (en) * | 1928-01-27 | 1929-05-28 | Abbott Lab | Cyclopentyl compound and process of making same |
GB532943A (en) * | 1938-08-05 | 1941-02-04 | Chem Ind Basel | Manufacture of alkamine esters and quaternary salts thereof |
US2265184A (en) * | 1938-08-05 | 1941-12-09 | Ciba Pharm Prod Inc | Basic esters and process of preparing same |
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CH221219A (en) * | 1938-08-05 | 1942-05-15 | Chem Ind Basel | Process for the preparation of a basic ester. |
CH221519A (en) * | 1938-08-05 | 1942-05-31 | Chem Ind Basel | Process for the preparation of a basic ester. |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2691656A (en) * | 1954-10-12 | L-methyl-j-piperidylmethyi | ||
DE961349C (en) * | 1951-07-20 | 1957-04-04 | Sterling Drug Inc | Process for the production of highly effective anticholinergic compounds |
US2987517A (en) * | 1954-04-20 | 1961-06-06 | Cilag Chemie | Alpha aryl-3-methyl-pentanoic acid-nu-lower alkyl heterocyclic esters |
DE1033659B (en) * | 1957-01-24 | 1958-07-10 | Siegfried Ag | Process for the preparation of basic di (cyclopentyl) acetic acid esters |
US3065134A (en) * | 1958-02-19 | 1962-11-20 | Lab Jacques Logeais Soc D Expl | Choleretic hydroxycycloaliphatic acid process |
EP0438837A2 (en) * | 1989-11-30 | 1991-07-31 | MANNESMANN Aktiengesellschaft | Device for blasting the inside of a pipe |
EP0438837A3 (en) * | 1989-11-30 | 1991-11-21 | Mannesmann Aktiengesellschaft | Device for blasting the inside of a pipe |
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