US2379474A - Heating cabinet, incubator, and the like - Google Patents

Heating cabinet, incubator, and the like Download PDF

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US2379474A
US2379474A US509731A US50973143A US2379474A US 2379474 A US2379474 A US 2379474A US 509731 A US509731 A US 509731A US 50973143 A US50973143 A US 50973143A US 2379474 A US2379474 A US 2379474A
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chamber
duct
air
tubes
incubator
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Bramson Maurice
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/809Incubators or racks or holders for culture plates or containers

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  • the present invention relates to heating cabinets, incubators and the like, and is more especially directed toward incubators for bacteriological work where extremely close temperature regulation is important.
  • heating cabinets, ovens and the like must be maintained during long periods at temperatures within very close limits.
  • bacteriological incubators which additionally require the maintenance of a uniform temperature throughout all parts of the heating chamber during the prolonged period, as well as the constant supply of a flow of fresh air which may circulate through the chamber.
  • the present invention contemplates improvements in such heating cabinets whereby the uniformity of temperature throughout the heating chamber may be maintained and the air circulated. According to the present invention these results are obtained by comparatively inexpensive parts properly located with respect to one another. No moving parts are required and no thermostatic control is necessary other than the one for the primary purpose of maintaining a uniform temperature over the prolonged period where heating is necessary.
  • the fresh air is admitted in such a manner that it is thoroughly mixed before it is discharged into the chamber so as to overcome differential temperatures in various parts of the chamber, and at the same time the radiation of heat from the heating source is reduced to an amount to where it can cause no local excess heating.
  • Figure 1 is a vertical sectional view through an incubator (with doors removed) taken on the line i-
  • Figure 1a is a fragmentary view similar to Figure 1 illustrating a modified form of construction
  • Figure 2 is a horizontal sectional view taken on the line 2-2 of Figure 1;
  • Figure 3 is a vertical sectional view taken on the line 3-3 of Figure l;
  • Figure 4 is a perspective view of the incubator at a reduced scale
  • Figures 5 and 6 are top plan and side elevational views of the damper control.
  • the incubator employs a large rectangular box-like structure Iii which may be supported on legs II. It is provided with two swinging doors I2, i2 and is arranged for using an extraneous heater, such,
  • the in-' cubator has double walls at the top, bottom, sides and back which contain insulation and the doors are also insulated.
  • the box has a sheet metal liner i5 with a rear wall 86, end walls I1 and IS, a top wall l3 and a bottom wall 20.
  • is at the front below the door opening.
  • This liner forms an upper five-sided chamber opening toward the front and a shallow five-sided chamber opening downwardly.
  • a partition 22 extends across the lower boxlike chamber and is secured in place to the side, front and rear elements l3, I], I8 and 2
  • the duct 23 communicates with a flue or stack 24 which is suitably secured to the side wall 18.
  • the duct 23 communicates with a tube 25 extending laterally as indicated.
  • the outer housing 30 has a rear wall 3
  • the liner is secured in the housing in any suitable manner and the space between the liner walls and the housing walls and between the top oi. the housing and a cover 31 is filed with suitable insulating material, such as glass fibre.
  • Tubes 35 extend down through aligned openings in the top and bottom walls of the duct 23 andare long enough to extend through a bottom plate 36 which is suitably secured in inturned flanges 31 around the lower edges of the side, front and back walls of the housing. Before this plate 36 is in inserted position the tubes are in place as well as spacers 38 and 39 and the space is filled with insulation as indicated. Alter the bottom plate 36 is in place the lower ends of the tubes are upset, as indicated in the drawings, so that the tubes are secured in place.
  • a bailie 40 is secured to the bottom plate 20 so as to form a manifold into which all the tubes 35 discharge the air warmed and drawn in by convection.
  • This baffle requires all the air to travel towards the left, as indicated in Figures 1 and 2 of the drawings, and to be discharged past the left edge 4
  • a heat baffle in the form of a lower plate 42 and an upper late 43 with interposed insulation as indicated.
  • This heat baifle may be secured in place by screws indicated at 44.
  • the front part of the cover 3i carries two tubes 45, 46 for thermometers (not shown).
  • the source of heat may be a continuously operated gas or liquid fuel burner or an intermittently operated electric heater. Where the fuel burner is used the flame is allowed to enter a cone holes 54 into the space between the cone 50 and the chimney ii, to pass through a tube 55 into the tube 2-5 and therefore into the duct 23.
  • the air entering the duct 23 at the right hand end will be at such a high temperature as to heat air coming through the right hand tube 3 to too high a temperature for direct admission into the incubator chamber, and it is for this reason and to avoid relatively strong jets of heated air that the bafile is utilized to accumulate all the heated air and mix it before it is admitted into the chamber.
  • a small amount of the air passing up through the bafile is allowed to enter the chamber through small holes 56 in the baffle and to thereby warm the bulb 51 of a thermal element which is connected to a bellows operator of conventional form enclosed in a casing indicated at 58 and arranged to act on the lever 59which supports the damper 53.
  • the thermal element 51 When the thermal element 51 is sati'sfied the bellows is expanded and the counterweight 50 opens the damper, and when the thermal element 51 is calling for heat the bellows i collapsed and the damper closed. Adjustment for the temperature is made by a knob 82 attached to the temperature responsive element so that its position can be adjusted and the exact temperature at which the damper is opened be controlled.
  • thermometer 63 is inserted into the tube 55 to facilitate adjusting the burner, and the bottom of the tube 55 is provided with an opening 64 which facilitates the admission of cold air into the duct when the damper 53 is opened so as to check the how of hot air and prevent continued rise in temperature after the thermostat has been satisfied.
  • Figure 1a illustrates the use of a manifold 55 in the'fresh air duct 66, this manifold taking in air from one end of the device and having a number of tubes 61 which open upwardly in the same way as the tubes 35 described above, so as to discharge air out under the bafile plate"! in the same manner as above described.
  • the manper in which the fresh air is introduced into the upwardly opening tubes will depend upon conditions met with in the design of the apparatus, for example, a number of laterally opening, individually arranged tubes may be employed instead of the manifold. It will also be understood that it is not always necessary to utilize the entire bottom of the chamber as duct surface.
  • a warming cabinet comprising means for defining a chamber for the reception of articles tobe heated, a vent for the chamber, the bottom of the-chamber being the top wall of a hot air duct, a heater for heating the duct hotter at one part than at another, upwardly opening tubes extending through the duct and opening below it so that fresh air may be heated in the tubes and circulate through the cabinet, and a baille plate above all the top tube openings and sloping downwardly toward the warmer part of the duct, the edge of the higher end of the baffle being spaced from the-adjacent side of the chamher to permit the-warmed air to rise.
  • a cabinet such as claimed in claim 1, having a temperature responsive device in the chamber for controlling the admission of heated air to the duct.
  • a cabinet such as claimed in claim 1, havin insulating material above the lower portion of the baffle to prevent radiation of heat from said portion of the bafiie into the chamber.
  • a cabinet such as claimed in claim 1, having a temperature responsive device carried by the bafile and controlling the admission of heated air to the duct.
  • An incubator or the like comprising a sheet metal liner forming an upper five-sided box-like chamber with an open front wall and having the bottom of the chamber disposed above the lower edges of the front, the rear and the sides of the liner to provide a lower downwardly opening rectangular chamber, a horizontal partition extending across the downwardly opening chamber to form a duct under the bottom of the first chamber, a flue carried by one end of the liner and communicating with the duct, a hot air supply for the other end of the duct, an outside housin about the liner and open at the front and bottom, a bottom plate across the bottom of the housing, insulation in the spaces between the housing and the liner top and sides and the bottom plate and partition, doors for the front opening, and fresh air tubes extending through the duct and the bottom plate for admitting fresh air to the upper chamber.
  • An incubator or the like having a liner providing a bottom wall and side and end walls for a. chamber, the bottom wall having tubes for the admission of heated fresh air, means for directing the flow of extraneously heated hot air underneath and across the said bottom wall whereby one end is heated more than the other and the fresh air admitted through the tubes nearer the source of heat is hotter than that admitted through the more remote tubes, a battle plate sloping upwardly away from the hotter end of the bottom, the upper edge of the bave plate being spaced from the front chamber wall, and an insulating bave above the lower end of the bafiie plate which diverts heated air toward the center of the chamber and preventsradiation of heat from the covered portion of the baffle plate.
  • An incubator or the like having means for defining a chamber, the chamber having a bottom wall which is the top of a duct for extraneousiy heated hot air and through which such hot air passes lengthwise, a row of vertical tubes extending through the duct for allowing the passage of warmed fresh air into the chamber of the incubator, a sloping cover plate secured to the top of the duct to form a common horizontal discharge manifold for all the tubes and being spaced farthest from the duct wall at the cooler end of the duct whereby the warmed fresh air must traverse the length of the manifold before being discharged into the chamber.

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  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)

Description

M. BRAMSON July 3, 1945.
HEATING CABINETS, INCUBATORS, AND THE LIKE Filed Nov. 10, 1943 2 Sheets-Sheet 2 INVENTOR MAURICE BRA MSON ATTORNEY Patented July 3, 1945 UNITED STATES PATENT OFFICE HEATING CABINET, INUUBATOR, AND THE LIKE Claims.
The present invention relates to heating cabinets, incubators and the like, and is more especially directed toward incubators for bacteriological work where extremely close temperature regulation is important.
Many forms of heating cabinets, ovens and the like must be maintained during long periods at temperatures within very close limits. There is a type of such heating cabinets and ovens known as bacteriological incubators which additionally require the maintenance of a uniform temperature throughout all parts of the heating chamber during the prolonged period, as well as the constant supply of a flow of fresh air which may circulate through the chamber.
The present invention contemplates improvements in such heating cabinets whereby the uniformity of temperature throughout the heating chamber may be maintained and the air circulated. According to the present invention these results are obtained by comparatively inexpensive parts properly located with respect to one another. No moving parts are required and no thermostatic control is necessary other than the one for the primary purpose of maintaining a uniform temperature over the prolonged period where heating is necessary.
To accomplish all this the fresh air is admitted in such a manner that it is thoroughly mixed before it is discharged into the chamber so as to overcome differential temperatures in various parts of the chamber, and at the same time the radiation of heat from the heating source is reduced to an amount to where it can cause no local excess heating.
Other and further objects will hereinafter appear as the description proceeds.
The accompanying drawings show, for purposes of illustrating the present invention, an embodiment in which the invention may take form, together with modifications of certain parts, it being understood that the drawings are illustrative of the invention rather than limiting the same.
In these drawings:
Figure 1 is a vertical sectional view through an incubator (with doors removed) taken on the line i-| of Figure 2 and showing parts in elevation and parts broken away;
Figure 1a is a fragmentary view similar to Figure 1 illustrating a modified form of construction;
Figure 2 is a horizontal sectional view taken on the line 2-2 of Figure 1;
Figure 3 is a vertical sectional view taken on the line 3-3 of Figure l;
Figure 4 is a perspective view of the incubator at a reduced scale; and
Figures 5 and 6 are top plan and side elevational views of the damper control.
In the embodiment shown in the drawings the incubator employs a large rectangular box-like structure Iii which may be supported on legs II. It is provided with two swinging doors I2, i2 and is arranged for using an extraneous heater, such,
for example, as a liquid fuel burner. The in-' cubator has double walls at the top, bottom, sides and back which contain insulation and the doors are also insulated.
The box has a sheet metal liner i5 with a rear wall 86, end walls I1 and IS, a top wall l3 and a bottom wall 20. A strip 2| is at the front below the door opening. This liner forms an upper five-sided chamber opening toward the front and a shallow five-sided chamber opening downwardly.
A partition 22 extends across the lower boxlike chamber and is secured in place to the side, front and rear elements l3, I], I8 and 2| of the liner so as to form a duct 23 of the full size of the bottom 20. At the left end of Figures 1 and 2 the duct 23 communicates with a flue or stack 24 which is suitably secured to the side wall 18. At the right end the duct 23 communicates with a tube 25 extending laterally as indicated. The outer housing 30 has a rear wall 3| and end walls 32, 32. It is open at the front and framed as indicated in the drawings for openings 33, 33 for the two doors.
The liner is secured in the housing in any suitable manner and the space between the liner walls and the housing walls and between the top oi. the housing and a cover 31 is filed with suitable insulating material, such as glass fibre. Tubes 35 extend down through aligned openings in the top and bottom walls of the duct 23 andare long enough to extend through a bottom plate 36 which is suitably secured in inturned flanges 31 around the lower edges of the side, front and back walls of the housing. Before this plate 36 is in inserted position the tubes are in place as well as spacers 38 and 39 and the space is filled with insulation as indicated. Alter the bottom plate 36 is in place the lower ends of the tubes are upset, as indicated in the drawings, so that the tubes are secured in place.
A bailie 40 is secured to the bottom plate 20 so as to form a manifold into which all the tubes 35 discharge the air warmed and drawn in by convection. This baffle requires all the air to travel towards the left, as indicated in Figures 1 and 2 of the drawings, and to be discharged past the left edge 4| of the baflle plate. As the air coming up through the tubes near the right hand side of the figure will be heated too hot and would heat the lower end of the baflle to too high a temperature and cause radiation, this radiation is prevented by a heat baffle in the form of a lower plate 42 and an upper late 43 with interposed insulation as indicated. This heat baifle may be secured in place by screws indicated at 44.
The warm air item the interior of the chamber escapes up through vent openings 45, 45, as indicated in Figure 4, and generally these openings will be provided with dust caps which are omitted from the drawings. The front part of the cover 3i carries two tubes 45, 46 for thermometers (not shown).
The source of heat may be a continuously operated gas or liquid fuel burner or an intermittently operated electric heater. Where the fuel burner is used the flame is allowed to enter a cone holes 54 into the space between the cone 50 and the chimney ii, to pass through a tube 55 into the tube 2-5 and therefore into the duct 23.
The air entering the duct 23 at the right hand end will be at such a high temperature as to heat air coming through the right hand tube 3 to too high a temperature for direct admission into the incubator chamber, and it is for this reason and to avoid relatively strong jets of heated air that the bafile is utilized to accumulate all the heated air and mix it before it is admitted into the chamber. A small amount of the air passing up through the bafile is allowed to enter the chamber through small holes 56 in the baffle and to thereby warm the bulb 51 of a thermal element which is connected to a bellows operator of conventional form enclosed in a casing indicated at 58 and arranged to act on the lever 59which supports the damper 53. When the thermal element 51 is sati'sfied the bellows is expanded and the counterweight 50 opens the damper, and when the thermal element 51 is calling for heat the bellows i collapsed and the damper closed. Adjustment for the temperature is made by a knob 82 attached to the temperature responsive element so that its position can be adjusted and the exact temperature at which the damper is opened be controlled.
A thermometer 63is inserted into the tube 55 to facilitate adjusting the burner, and the bottom of the tube 55 is provided with an opening 64 which facilitates the admission of cold air into the duct when the damper 53 is opened so as to check the how of hot air and prevent continued rise in temperature after the thermostat has been satisfied.
Figure 1a. illustrates the use of a manifold 55 in the'fresh air duct 66, this manifold taking in air from one end of the device and having a number of tubes 61 which open upwardly in the same way as the tubes 35 described above, so as to discharge air out under the bafile plate"! in the same manner as above described.
It will, of course, be u derstood that the manper in which the fresh air is introduced into the upwardly opening tubes will depend upon conditions met with in the design of the apparatus, for example, a number of laterally opening, individually arranged tubes may be employed instead of the manifold. It will also be understood that it is not always necessary to utilize the entire bottom of the chamber as duct surface.
Since it is obvious that the invention may be embodied in other forms and constructions within the scope of the claims, I wish it to be understood that the particular forms shown are but two of'these forms, and various modifications and changes being possible, I do not otherwise limit myself in any way with respect thereto.
What is claimed is:
1. A warming cabinet comprising means for defining a chamber for the reception of articles tobe heated, a vent for the chamber, the bottom of the-chamber being the top wall of a hot air duct, a heater for heating the duct hotter at one part than at another, upwardly opening tubes extending through the duct and opening below it so that fresh air may be heated in the tubes and circulate through the cabinet, and a baille plate above all the top tube openings and sloping downwardly toward the warmer part of the duct, the edge of the higher end of the baffle being spaced from the-adjacent side of the chamher to permit the-warmed air to rise.
2. A cabinet such as claimed in claim 1, having a temperature responsive device in the chamber for controlling the admission of heated air to the duct.
3. A cabinet such as claimed in claim 1, havin insulating material above the lower portion of the baffle to prevent radiation of heat from said portion of the bafiie into the chamber.
4. A cabinet such as claimed in claim 1, having a temperature responsive device carried by the bafile and controlling the admission of heated air to the duct.
5. In an incubator or the like, means for defining a. chamber, insulation for the chamber, the chamber having a bottom at least a portion of which is formed by a sheet metal duct for the passage'of hot air lengthwise of the duct, fresh air tubes extending through the duct and opening above and below the meta baifie plate mounted adjacent the top wall of the duct andsloping upwardly away from the warmer end of the duct, the edge of the baflle atits higher end being spaced from the adjacent side of the chamber so that warmed air supplied by the fresh air tubes may rise into the chambenthe lower end of the baflle being covered by an insulating pad which prevents radiation of heat from the warmer end of the bafiie.
6. The improvement in rectangular heatin chambers with side walls, a top and a bottom, and having as a source of heat therefor a duct extending immediately under the bottom of the chamber, a heater connected to one end of the duct, and a draft tube connected to the other end of the'duct, whereby one end of the duct is hotter than the other, which comprises upwardly opening fresh air tubes extending completely through the duct and distributed rom t e hotter end to the cooler end, and means for baffling the flow of incoming fresh air to require it to flow horizontally toward the end wall of the chamber near the draft tube and prevent its rise directly from the hotter end of the duct.
'l. The improvement claimed in claim 6, wherein the hotter end of the baffle is insulated to prevent heat radiation.
8. An incubator or the like comprising a sheet metal liner forming an upper five-sided box-like chamber with an open front wall and having the bottom of the chamber disposed above the lower edges of the front, the rear and the sides of the liner to provide a lower downwardly opening rectangular chamber, a horizontal partition extending across the downwardly opening chamber to form a duct under the bottom of the first chamber, a flue carried by one end of the liner and communicating with the duct, a hot air supply for the other end of the duct, an outside housin about the liner and open at the front and bottom, a bottom plate across the bottom of the housing, insulation in the spaces between the housing and the liner top and sides and the bottom plate and partition, doors for the front opening, and fresh air tubes extending through the duct and the bottom plate for admitting fresh air to the upper chamber.
9. An incubator or the like having a liner providing a bottom wall and side and end walls for a. chamber, the bottom wall having tubes for the admission of heated fresh air, means for directing the flow of extraneously heated hot air underneath and across the said bottom wall whereby one end is heated more than the other and the fresh air admitted through the tubes nearer the source of heat is hotter than that admitted through the more remote tubes, a battle plate sloping upwardly away from the hotter end of the bottom, the upper edge of the baiile plate being spaced from the front chamber wall, and an insulating baiile above the lower end of the bafiie plate which diverts heated air toward the center of the chamber and preventsradiation of heat from the covered portion of the baffle plate.
10. An incubator or the like having means for defining a chamber, the chamber having a bottom wall which is the top of a duct for extraneousiy heated hot air and through which such hot air passes lengthwise, a row of vertical tubes extending through the duct for allowing the passage of warmed fresh air into the chamber of the incubator, a sloping cover plate secured to the top of the duct to form a common horizontal discharge manifold for all the tubes and being spaced farthest from the duct wall at the cooler end of the duct whereby the warmed fresh air must traverse the length of the manifold before being discharged into the chamber.
MAURICE BRAMSON.
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US6174670B1 (en) 1996-06-04 2001-01-16 University Of Utah Research Foundation Monitoring amplification of DNA during PCR
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US20030217840A1 (en) * 2000-09-05 2003-11-27 Oldenburg Kevin R. Rapid thermal cycling device
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US20050000804A1 (en) * 2002-01-08 2005-01-06 Oldenburg Kevin R. Rapid thermal cycling device
US20050034849A1 (en) * 2002-01-08 2005-02-17 Oldenburg Kevin R. Method and apparatus for severing organic molecules by ultrasound
US20050064582A1 (en) * 1990-06-04 2005-03-24 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6787338B2 (en) 1990-06-04 2004-09-07 The University Of Utah Method for rapid thermal cycling of biological samples
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US7745205B2 (en) 1990-06-04 2010-06-29 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US20050064582A1 (en) * 1990-06-04 2005-03-24 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US6245514B1 (en) 1996-06-04 2001-06-12 University Of Utah Research Foundation Fluorescent donor-acceptor pair with low spectral overlap
US6174670B1 (en) 1996-06-04 2001-01-16 University Of Utah Research Foundation Monitoring amplification of DNA during PCR
US7670832B2 (en) 1996-06-04 2010-03-02 University Of Utah Research Foundation System for fluorescence monitoring
US20090311673A1 (en) * 1996-06-04 2009-12-17 Wittwer Carl T Nucleic acid amplification methods
US6569627B2 (en) 1996-06-04 2003-05-27 University Of Utah Research Foundation Monitoring hybridization during PCR using SYBR™ Green I
US20090258414A1 (en) * 1996-06-04 2009-10-15 Wittwer Carl T System for fluorescence monitoring
US20060029965A1 (en) * 1996-06-04 2006-02-09 Wittwer Carl T System for fluorescence monitoring
US6232079B1 (en) 1996-06-04 2001-05-15 University Of Utah Research Foundation PCR method for nucleic acid quantification utilizing second or third order rate constants
US20030217840A1 (en) * 2000-09-05 2003-11-27 Oldenburg Kevin R. Rapid thermal cycling device
US7025120B2 (en) 2000-09-05 2006-04-11 Oldenburg Kevin R Rapid thermal cycling device
US6640891B1 (en) 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7373968B2 (en) 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
US20050034849A1 (en) * 2002-01-08 2005-02-17 Oldenburg Kevin R. Method and apparatus for severing organic molecules by ultrasound
US20050000804A1 (en) * 2002-01-08 2005-01-06 Oldenburg Kevin R. Rapid thermal cycling device
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method

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