US2271638A - Germicide - Google Patents
Germicide Download PDFInfo
- Publication number
- US2271638A US2271638A US370419A US37041940A US2271638A US 2271638 A US2271638 A US 2271638A US 370419 A US370419 A US 370419A US 37041940 A US37041940 A US 37041940A US 2271638 A US2271638 A US 2271638A
- Authority
- US
- United States
- Prior art keywords
- germicide
- solution
- molecular weight
- caustic
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002070 germicidal effect Effects 0.000 title description 25
- 239000000243 solution Substances 0.000 description 19
- 239000003518 caustics Substances 0.000 description 9
- 230000002147 killing effect Effects 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 229910001868 water Inorganic materials 0.000 description 5
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 241001467018 Typhis Species 0.000 description 3
- 229960002089 ferrous chloride Drugs 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 239000000417 fungicide Substances 0.000 description 3
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 241000233866 Fungi Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000095 emetic effect Effects 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000000266 injurious effect Effects 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Definitions
- This invention relates to germicides, and has for one of its objects, a germicidal product that is non-caustic and non-injurious to body tissue, and which product is non-toxic in any degree of concentration, and is healing to injured tissue.
- Another object is a germicide that has a faster killing action on microtirganisms, than any other non-caustic germicide of which I am aware and which germicide is considerably more germicidal than phenol and other caustic germicides of which I am aware when used in equivalent solutions.
- a still further object is a germicide that may be used in any degree of dilution on injured or uninjured body tissue with perfect safety, and the killing power of which, on microtirganisms, whether of the type such as Trycophyton interdigitalis, a fungus, or of the true germ type, such as E. typhi or S. aureus, and which germicide even in a relatively high dilution, will rapidly and positively kill microorganisms having a resistance to killing at least equal to that of Eberthella typhosa, Staphylococcus aures, or Tricophytan tonsuraus.
- germicide does not refer to antiseptics that are merely disinfectants or deodori'zers, but one that is capable of positively and effectively killing microiirganisms such as those already mentioned herein, and which 'are deemed to be among the most highly resistant to killing. To be effective, it is obvious that a germicide or fungicide must act quickly.
- my germicide or fungicide product comprises a mixture of one gram molecular weight of ferrous chloride to each two grams molecular weight of ferric chloride.
- this mixture is effective when used on body tissue, there being suflicient moisture on the skin or in the blood to effect the desired result, but in use, it is preferably in a solution of water, alcohol or both.
- a solution is a concentrated solution, but the preferred solution for a surgical germicide is a 4 to 5% solution of the solid comprising one gram molecular weight ferrous chloride with two grams molecular weight ferric chloride dissolved in from 12 to 13% iso propyl alcohol.
- the alcohol facilitates penetration, and such solution, tested by standard and approved methods against S. aureus and E.
- a non-caustic germicide mixture for solution in H2O comprising FeClz and FeCl: in the ratio of one gram molecular weight of FeClz to each two grams molecular weight of FeCls.
- a non-caustic germicidal solution comprising FeCh and FeCl3, in the ratio of one gram molecular weight of FeCl: to each two grams molecular weight of FeCl: dissolved in water.
- a non-caustic germicidal solution comprising FeCl-z and FeCla, in the ratio of one gram molecular weight of FeCh to each two grams molecular weight of FeCh, dissolved in alcohol and water.
- a non-caustic germicidal solution comprising a 4% to 5% solution of FeCl: and FeCl: in which the liquid is H20 and alcohol, the said alcohol being from 12% to 13% by weight of the total amount of liquid and there being substantially one gram only, molecular weight, of the FeClz to each two grams molecular weight of the FeCla in the solution.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Inorganic Chemistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
Patented Feb. 3, 1942 GERMICIDE Howard L. Guest, Roseville, CaliL, assignor of seventy-five per cent to L. A. Gunther, Robbins,
Calif.
N Drawing. Application December 16, 1940, Serial No. 370,419
4 Claims.
This invention relates to germicides, and has for one of its objects, a germicidal product that is non-caustic and non-injurious to body tissue, and which product is non-toxic in any degree of concentration, and is healing to injured tissue.
This application is a continuation-in-part of my application, Serial No. 364,244, filed Novemher 4, 1940, and now Patent No. 2,209,454. V
Another object is a germicide that has a faster killing action on microtirganisms, than any other non-caustic germicide of which I am aware and which germicide is considerably more germicidal than phenol and other caustic germicides of which I am aware when used in equivalent solutions.
A still further object is a germicide that may be used in any degree of dilution on injured or uninjured body tissue with perfect safety, and the killing power of which, on microtirganisms, whether of the type such as Trycophyton interdigitalis, a fungus, or of the true germ type, such as E. typhi or S. aureus, and which germicide even in a relatively high dilution, will rapidly and positively kill microorganisms having a resistance to killing at least equal to that of Eberthella typhosa, Staphylococcus aures, or Tricophytan tonsuraus.
Other objects and advantages will appear in the following description:
Before describing my germicide and fungicide in detail, it is important to understand that the word germicide, as used in the description and claims, does not refer to antiseptics that are merely disinfectants or deodori'zers, but one that is capable of positively and effectively killing microiirganisms such as those already mentioned herein, and which 'are deemed to be among the most highly resistant to killing. To be effective, it is obvious that a germicide or fungicide must act quickly.
The caustic nature of most germicides prevents their use safely in a concentration suitable for most eifectively destroying resistant bacteria in tissue. Also if accidentally taken internally, the results may be fatal to a person, or irreparable injury will generally follow, unless prompt steps are taken to arrest its action on internal tissue. With my germicide, no injury to any tissue can result, whether used on broken tissue or whether taken internally, in which latter instance it merely has an emetic action if a suflicient amount is taken.
Briefly described, my germicide or fungicide product comprises a mixture of one gram molecular weight of ferrous chloride to each two grams molecular weight of ferric chloride. In dry form, this mixture is effective when used on body tissue, there being suflicient moisture on the skin or in the blood to effect the desired result, but in use, it is preferably in a solution of water, alcohol or both. A solution is a concentrated solution, but the preferred solution for a surgical germicide is a 4 to 5% solution of the solid comprising one gram molecular weight ferrous chloride with two grams molecular weight ferric chloride dissolved in from 12 to 13% iso propyl alcohol. The alcohol facilitates penetration, and such solution, tested by standard and approved methods against S. aureus and E. typhi, as directed for testing germicides intended for personal use (Method of Reddishas recommended by American Public Health Association) will kill S. aureus and E. typhi in less than one minutes exposure. A 4% solution, exclusive of the alcohol, will kill these microorganisms in less than four minutes after exposure, and, of course, the killing time is proportionally reduced with an increase in the concentration of the solution.
It is pertinent to note that the substantially exact ratio of one gram molecular weight of vFeClz to two grams molecular weight of FeCh must be maintained in whatever solution is prepared, in order to obtain the desired results. The degree of concentration of the solution, may, of course, vary, according to the strength desired.
While I am aware of the fact that ferric chloride alone has been used before on traumatized tissue as a styptic or as an astringent, according to the authorities (Redeal, Disinfection and Disinfectants, second edition, page 121), it does not kill bacteria, and is condemned. It has no ofiicial recognition. Ferrous chloride alone has also been found to be absolutely non-germicidal. Ap-
plicant has discovered, however, that the combination of the two in the proportion herein described, produces a non-toxic, non-caustic germicide of materially greater killing power thanthe combination of ferric sulphate and ferrous sulphate as described in his United States Letters isms. Commercially, a mixture of the salts in the proper ratio to each other, may therefore be supplied to physicians or users for preparing the solution desired, or the solution may be supplied already mixed.
Having described my invention, I claim:
1. A non-caustic germicide mixture for solution in H2O comprising FeClz and FeCl: in the ratio of one gram molecular weight of FeClz to each two grams molecular weight of FeCls.
2. A non-caustic germicidal solution comprising FeCh and FeCl3, in the ratio of one gram molecular weight of FeCl: to each two grams molecular weight of FeCl: dissolved in water.
fit
3. A non-caustic germicidal solution comprising FeCl-z and FeCla, in the ratio of one gram molecular weight of FeCh to each two grams molecular weight of FeCh, dissolved in alcohol and water. v
4. A non-caustic germicidal solution comprising a 4% to 5% solution of FeCl: and FeCl: in which the liquid is H20 and alcohol, the said alcohol being from 12% to 13% by weight of the total amount of liquid and there being substantially one gram only, molecular weight, of the FeClz to each two grams molecular weight of the FeCla in the solution.
HOWARD L. GUEST.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US370419A US2271638A (en) | 1940-12-16 | 1940-12-16 | Germicide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US370419A US2271638A (en) | 1940-12-16 | 1940-12-16 | Germicide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2271638A true US2271638A (en) | 1942-02-03 |
Family
ID=23459578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US370419A Expired - Lifetime US2271638A (en) | 1940-12-16 | 1940-12-16 | Germicide |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2271638A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2585965A (en) * | 1946-03-01 | 1952-02-19 | Anthony J Salle | Iodine solution comprising an oxidation-reduction system |
-
1940
- 1940-12-16 US US370419A patent/US2271638A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2585965A (en) * | 1946-03-01 | 1952-02-19 | Anthony J Salle | Iodine solution comprising an oxidation-reduction system |
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