US2193188A - Noncapillary silk suture and method of preparing the same - Google Patents

Noncapillary silk suture and method of preparing the same Download PDF

Info

Publication number
US2193188A
US2193188A US21414738A US2193188A US 2193188 A US2193188 A US 2193188A US 21414738 A US21414738 A US 21414738A US 2193188 A US2193188 A US 2193188A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
silk
strand
suture
noncapillary
method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Theodore F Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Wyeth Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/14Post-treatment to improve physical properties
    • A61L17/145Coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/26Textiles, e.g. towels, beds, cloths
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913Rod, strand, filament or fiber
    • Y10T428/2933Coated or with bond, impregnation or core
    • Y10T428/2964Artificial fiber or filament
    • Y10T428/2965Cellulosic

Description

Patented Mar. 12, 1940 v UNITED STATES NONCAPILLARYSILK SUTURE AND METHOD "OF PREPARING THE SAME Theodore F. Bradley, Stamford, Conn, assignor to American Cyanamid Company, New

York,

N. Y., a corporation of Maine I NoDrawing. Application June 16, 1938, Serial No. 214,147

9 Claims. (Cl. 128-3355) The present invention relates to a method of making a noncapillary silk suture for surgical purposes and the suture per se. 7

Silkthreads, made by twisting or braiding a number of degummed and cleaned raw silk filaments, have been used in surgery as suture material for many years. However, when such a silk suture is embedded in infected tissue, bacteria are harbored in its interstices and the suture becomes a nidus of infection which does not subside until the silk sloughs out or is removed surgically. Because of its capillarity, there is always the possibility of the exposedend of a silk suture acting as a wick to carry infection into the tissue. Thematerial, therefore, has never come into general surgical use for this purpose.

It is a principal object of the invention to produce a silk suture made of a number of silk threads, twisted, braided, woven or otherwise associated together into a strand, which will be substantially noncap-illary, and this object can most effectively be accomplished by coating such suture material with a composition which will present an unbroken surface to moisture.

The proposal toreducethecapillarity of silk sutures is not a new one. Many attempts have been made to this end and while it has been found not particularly difficult to-treat a braided or twisted surgical silk so as to produce a satisfactory degree of noncapillarity, yet such treat-- ment resulted in lending undesirable characteristics to the product or was unsatisfactory for other reasons.

A surgical silk suitable for useas a suture must be soft, pliable, nonacidic, noncorrosive and physiologically harmless and be capable of withstanding heat or chemical sterilization. These factors have generally stood in the way of the production of a successful noncapillary surgeons silk, for any treatment which decreased capillarity was objectionable because such product did not meet the other necessary qualifications or because the stringent conditions of sterilizawithout detrimental effect.

silk suture by applying to the silk suture stock, hereinafter referred to as a strand, a composition including ethyl cellulose in a volatile solvent and then permitting or inducing the solvent to evaporate. Under these conditions, the ethyl cellulose forms an unbroken film on the exterior periphery of the suture strand and even penetrates the same to a desired extent, whereby the capillarity of the strand is reduced.

A noncapillary suture thus produced will withstand the usual heat and/or chemical st'erilization without substantial decrease in its noncapillarity. Where the sterilization treatment consists in contact with hot liquids, such as hot mineral 'oil, the suture will withstand the necessary high temperatures for the required periods Such heat sterilization treatment in oil is even beneficial in that it hasa tendency to maintain the pliability of the suture, and in use even when the excess oil is removed, a slight film thereof remains which, due to its water repellency, assists in maintaining the noncapillarity of the product.

The invention further contemplates a substantially noncapillary silk suture product in which the silk strand or strands are provided with one or more coatings of ethyl cellulose with or without an additional superficial coating of oil.

Alarge number of coatingand impregnating compositions were found to be satisfactory from the standpoint of actually reducing capillarity to the desired degree when applied to twisted or braided silk suture stock but resulted in lending stillness, u'npliability or other undesirable characteristics to the product, or the noncapillarity was materially destroyed when such products were subjected to heat and/or chemical sterilization or to other conditions to which sutures may be normally subjected.

Ethyl cellulose was found to be of outstanding value in that it met all of the stringent requirements without producing detrimental eifects while at the same time producing reduction in capillarity to the desired degree with optimum permanence.

In preparing the ethyl cellulose solution with which the silk stock is to be treated, ethyl cellulose of various viscosities and different solvents may be employed. While ethyl cellulose of viscosities of from 10 to centipoises has been 50 used for these compositions, such as the methyl 5 or ethyl ether of ethylene glycol, toluene, ethanol or mixtures thereof, as well as other known solvents, the proportions being varied to give the desired concentration of ethyl cellulose. Mis cible diluents may also be employed and where these are noninflammable, such as carbon tetra chloride, their use may be desirable under some circumstances.

The preferred coating composition comprises the following substances in substantially the proportions specified:

Solution A Grams Ethyl cellulose20 centipoise grade 40 Toluene 120 Ethanol 40 200 (20% solids) Solution B Grams Solution A 40 Ethanol 10 Toluene 50 100 (8% solids) Suture stock silk may then be immersed in, sprayed or otherwise contacted with, such a solution for from one to two minutes, the excess solution removed and then the coated strand airdried or preferably at some elevated temperature to remove all of the volatile solvent. This operation may be repeated as many times as necessary in order to produce a coating of the desired thickness or Weight, dependent upon the circumstances. In order to reduce fire hazard due to the infiammability of the above solvents, requisite amounts of carbon tetra chloride may be added thereto as desired.

After the silk has thus been treated to render it noncapillary, it may be out into the required lengths, wound into small coils, placed in glass tubes, which are filled with a light mineral oil and then sealed by fusion of the glass, the sealed tubes may then be placed in an autoclave and heat sterilized. When this is complete, the tubes are ready for packaging. While the above method of sterilization is preferred, other standardized procedures may likewise be employed.

While the invention has been described with specific reference to certain embodiments, it is to be understood that it is not to be limited thereto but is to be construed broadly and restricted solely by the scope of the claims.

"coated with ethyl cellulose and having a superficial exterior coating of oil.

3. A substantially noncapillary non-water absorptive silk suture comprising a silk strand coatedwith ethyl cellulose and having a superficial exterior coating of mineral oil.

4. A method of making a substantially noncapillary silksuture which includes the following steps: contacting a silk strand with a solution of ethyl cellulose in an organic solvent, removing the strand from the solution and evaporating the solvent from the ethyl cellulose so as to produce an adherent coating of the latter on the strand.

5. A method of'making a substantially noncapillary silk suture which includes the following steps: immersing a silk strand in a solution of ethyl cellulose in an organic solvent, removing the strand from the solution, removing the excess solution from the strand and drying the strand.

6. A method of making a substantially noncapillary silk suture which includes the following steps: immersing the silk strand in ethyl cellulose dissolved in a mixture of toluene and ethyl alcohol, removingthe strand from the solution and drying the strand.

7. A method of making a substantially noncapillary silk suture which includes the following steps: immersing the silk strand in a solution of 20 centipoise viscosity ethyl cellulose in an organic solvent, removing the strand from the solution anddrying the strand.

8. A method of making a substantially noncapillary silk suture which includes the following steps: immersing a silk strand in an 8% solution of 20 centipoise viscosity ethyl cellulose in an organic solvent, removing the strand from the solution and drying the strand.

9. A method of making a substantially noncapillary silk suture which includes the following steps: immersing a silk strand in a solution of ethyl cellulose in an organic solvent, removing the strand from the solution and evaporating the solvent from the ethyl cellulose so as to produce an adherent coating of the latter on the strand and sterilizing the coated strand in mineral oil.

THEODORE F. BRADLEY.

US2193188A 1938-06-16 1938-06-16 Noncapillary silk suture and method of preparing the same Expired - Lifetime US2193188A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US2193188A US2193188A (en) 1938-06-16 1938-06-16 Noncapillary silk suture and method of preparing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2193188A US2193188A (en) 1938-06-16 1938-06-16 Noncapillary silk suture and method of preparing the same

Publications (1)

Publication Number Publication Date
US2193188A true US2193188A (en) 1940-03-12

Family

ID=22797954

Family Applications (1)

Application Number Title Priority Date Filing Date
US2193188A Expired - Lifetime US2193188A (en) 1938-06-16 1938-06-16 Noncapillary silk suture and method of preparing the same

Country Status (1)

Country Link
US (1) US2193188A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2578664A (en) * 1947-05-08 1951-12-18 Johnson & Johnson Sanitary napkin
US2734506A (en) * 1956-02-14 Silk sutures and ligatures
US2899337A (en) * 1955-03-15 1959-08-11 Fibrous absorbent ball and method of producing same
US3105493A (en) * 1960-04-21 1963-10-01 Phillips Petroleum Co Suture
US3187752A (en) * 1962-04-27 1965-06-08 American Cyanamid Co Non-absorbable silicone coated sutures and method of making
US3390681A (en) * 1966-04-04 1968-07-02 Sutures Inc Polyester suture having improved knotting characteristics
US3424164A (en) * 1966-05-20 1969-01-28 Ethicon Inc Silk suture
US3665927A (en) * 1968-05-29 1972-05-30 Sutures Inc Impregnation of polyfilamentous sutures with synthetic polymer particles
US3963031A (en) * 1974-12-11 1976-06-15 Ethicon, Inc. Juncture-lubricated needle-suture combination
US4865031A (en) * 1985-07-12 1989-09-12 Keeffe Paul J O Fabric and method of use for treatment of scars
US20020193829A1 (en) * 2001-03-26 2002-12-19 Tyco Healthcare Group Lp Oil coated sutures
EP1448765A2 (en) * 2001-11-16 2004-08-25 Tufts University Matrix for the production of tissue engineered ligaments, tendons and other tissue

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734506A (en) * 1956-02-14 Silk sutures and ligatures
US2578664A (en) * 1947-05-08 1951-12-18 Johnson & Johnson Sanitary napkin
US2899337A (en) * 1955-03-15 1959-08-11 Fibrous absorbent ball and method of producing same
US3105493A (en) * 1960-04-21 1963-10-01 Phillips Petroleum Co Suture
US3187752A (en) * 1962-04-27 1965-06-08 American Cyanamid Co Non-absorbable silicone coated sutures and method of making
US3390681A (en) * 1966-04-04 1968-07-02 Sutures Inc Polyester suture having improved knotting characteristics
US3424164A (en) * 1966-05-20 1969-01-28 Ethicon Inc Silk suture
US3665927A (en) * 1968-05-29 1972-05-30 Sutures Inc Impregnation of polyfilamentous sutures with synthetic polymer particles
US3963031A (en) * 1974-12-11 1976-06-15 Ethicon, Inc. Juncture-lubricated needle-suture combination
US4865031A (en) * 1985-07-12 1989-09-12 Keeffe Paul J O Fabric and method of use for treatment of scars
US20020193829A1 (en) * 2001-03-26 2002-12-19 Tyco Healthcare Group Lp Oil coated sutures
US20070265660A1 (en) * 2001-03-26 2007-11-15 Kennedy John J Oil coated sutures
EP1448765A2 (en) * 2001-11-16 2004-08-25 Tufts University Matrix for the production of tissue engineered ligaments, tendons and other tissue
EP2319547A3 (en) * 2001-11-16 2011-08-24 Tufts University Matrix for the production of ligaments, tendons and other tissue

Similar Documents

Publication Publication Date Title
US4027676A (en) Coated sutures
US2108765A (en) Preserving and disinfecting media
US4349470A (en) Protein polymer hydrogels
US2459896A (en) Silver impregnation
US4105034A (en) Poly(alkylene oxalate) absorbable coating for sutures
US2693438A (en) Preformed, nonadherent films for application to open lesions
US5108424A (en) Collagen-impregnated dacron graft
US5460962A (en) Peracetic acid sterilization of collagen or collagenous tissue
US20030236552A1 (en) Siliconized surgical needles and methods for their manufacture
US4416814A (en) Protein polymer hydrogels
US2872428A (en) Polyepoxide emulsions and method of treating textiles therewith
US8133269B2 (en) Vascular stent
US5116552A (en) Process for preparation of dried collagen sponge
GB538865A (en) Improvements relating to knitted fabrics and manufactured knitted articles
US3862452A (en) Hydrogel substitutes for tubular somatic organs
US5925065A (en) Coated gut suture
US2484813A (en) Spun suture
US2989755A (en) Surgeons' gloves and method of making the same
US2582242A (en) Cast for orthopedic use
US2472485A (en) Catheter-type instrument
US2475697A (en) Treatment of collagen strands
US2072302A (en) Polymerized vinyl alcohol articles and processes of making same
Cantore et al. Neurosurgical use of human dura mater sterilized by gamma rays and stored in alcohol: long-term results
EP0494648A2 (en) Siliconized surgical needle and method for its manufacture
US2734506A (en) Silk sutures and ligatures