Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D213/81—Amides; Imides
  • C07D213/82—Amides; Imides in position 3

Definitions

• pyridine carboxylic acids can give new amido derivatives with amines such as morpholine (a complex function compound) giving results superior to those obtained up to this time with other derivatives of analogous kind.
• Our invention which is based upon the foregoing therapeutic discovery consists essentially in reacting, in the presence of suitable dehydrating reagents, and especially in the presence of phosphorus oxy-chloride, a pyridine carboxylic acid (alpha, beta or gamma) with morpholine, i. e., a secondary amine of the following formula:
• N o CH CQz which exhibits both a secondary amine function and an ether function.
• Example I We mix, as intimately as possible, 83 parts by weight of morpholine with 110 parts by weight of nicotinic acid and we add 50 parts by weight of phosphorus oxychloride, taking care that the reaction does not become too violent but, however, raising the temperature sufficiently to enable the reaction to proceed.
• This amide which at first has a viscous consistency, subsequently solidifies to form a solid which crystallizes normally and melts at a temperature of about 70 C. Its formula is:
• Example II hours we again add 9 kilograms of morpholine and the operation is continued.
• therapeutically useful compound having a melting pointof about 70 C.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Pyridine Compounds (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=26214028

Family Applications (1)

Country Status (5)

Cited By (3)

• 0
  • BE BE424052D patent/BE424052A/xx unknown
  • NL NL46009D patent/NL46009C/xx active
• 1937
  • 1937-08-17 US US159604A patent/US2188244A/en not_active Expired - Lifetime
  • 1937-10-11 CH CH200846D patent/CH200846A/fr unknown
  • 1937-10-12 GB GB27725/37A patent/GB503780A/en not_active Expired

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