US2056779A - Medicament for the treatment of burns - Google Patents
Medicament for the treatment of burns Download PDFInfo
- Publication number
- US2056779A US2056779A US705A US70535A US2056779A US 2056779 A US2056779 A US 2056779A US 705 A US705 A US 705A US 70535 A US70535 A US 70535A US 2056779 A US2056779 A US 2056779A
- Authority
- US
- United States
- Prior art keywords
- oil
- ointment
- sulphonated
- tannic acid
- burns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title description 4
- 239000003921 oil Substances 0.000 description 28
- 235000019198 oils Nutrition 0.000 description 28
- 239000002674 ointment Substances 0.000 description 26
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 17
- 239000001263 FEMA 3042 Substances 0.000 description 17
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 17
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 17
- 229940033123 tannic acid Drugs 0.000 description 17
- 235000015523 tannic acid Nutrition 0.000 description 17
- 229920002258 tannic acid Polymers 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000007935 neutral effect Effects 0.000 description 7
- 239000002253 acid Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000001993 wax Substances 0.000 description 5
- RGCKGOZRHPZPFP-UHFFFAOYSA-N alizarin Chemical compound C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 4
- 229960005274 benzocaine Drugs 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229940045860 white wax Drugs 0.000 description 3
- CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 2
- 229960005213 amylmetacresol Drugs 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003883 ointment base Substances 0.000 description 2
- 238000009877 rendering Methods 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WHRZCXAVMTUTDD-UHFFFAOYSA-N 1h-furo[2,3-d]pyrimidin-2-one Chemical compound N1C(=O)N=C2OC=CC2=C1 WHRZCXAVMTUTDD-UHFFFAOYSA-N 0.000 description 1
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 235000006173 Larrea tridentata Nutrition 0.000 description 1
- 244000073231 Larrea tridentata Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 229960002126 creosote Drugs 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Definitions
- Afurther object is to provide a of bland ingredients, solid and liquid, to protannic acid ointment which can itself be reduce an ointment of smooth texture, of summoved from the burned surface by the use of cient softness for easy application, and yet of 15 water alone.
- the insufflcient viscosity to remain in 'place well at the vention comprises the novel composition of matbody temperature of the burned surface,and ter hereinafter described. still leave the ointment readily emulsifiable;
- an important feature of the invention is the this without using a large amount of the emuluse of a base or menstruum which is readily sifiable menstruum.
- the bland ingree 2o emulsifiable, in water preferably spontaneousdients,consisting of, say, neutral white parafly, so that an ointment which contains a wax fin oil of medium viscosity, white wax, and solid will not be repelled by a watery exudate of the paraflin,may constitute more than fifty per burned surface but will diffuse in the same and cent of the whole ointment, by weight, and the thereby bring the tannic acid quickly into consulphonated oil menstruum no more than fif- 25 tact with the injured tissue.
- the paraflln oil may vary from about 30 is best obtained by the use of a mixture of sulto 40 per c n depending on e viscosity phonated oils, of different surface activities, in sired. If white wax is used without solid p such proportions that the net tension, so to fin a little borax, say .75 to 1 per cent, may be 35 speak, is such as will give the desired capability added to assist in emulsiflcation, but borax tends of easy, preferably spontaneous, emulsiflcation.
- the sulphonated sperm oil creosote or phenolic derivative may be used to should be neutral.
- the other oil may be a suladva ta p a y amyl m t cresol, a d as phonated petroleum oil, preferably about the an analgesicIprefer p-ethyl aminobenzoate, also same as ordinary glycerin in viscosity, or a sulknown as benzocaine, but any other compatible phonated vegetable oil, for example sulphonated substance of like properties may be used for the castor oil (commonly known as Turkey-red oil) purpose.
- a relatively low water content say 15 to per cent, is' desirable, as the water is then so well surrounded by the unctuous or oily material that the loss of water .by evaporation after the dressing is applied to the burn is minimized and the ointment does not become dry or stiff.
- the ointment may be packaged in collapsible be employed if the blackening incident to simultaneous contact with metal and air is not objectionable.
- An ointment for the treatment of burns containing tannic acid in aqueous solution, and a sulphonated oil menstruum comprising neutral sulphonated sperm oil and neutral sulphonated petroleum oil in the ratio, by weight, of about 3:2, and in total amount to render the ointment spontaneously diflusible in water.
- a sulphonated oil menstruum comprising neutral sulphonated sperm oil and acid sulphonated castor oil in the ratio, by weight, of about 3:2, and in total amount adapted to render the ointment spontaneously diflusible in water.
- a tannic acid ointment for the treatment of burns which contains tannic acid in aqueous solution, and which also contains a sulphonated oil menstruum, giving an oil-water interfacial surface tension less than 0.5 dyne per centimeter,
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
' Patented Oet. 1936 I Q It 3 UNITED STATES PATENT OFFICE MEDICAMENT FOR THE TREATMENT OF BURNS Russel J. Fosbinder, Short Hills, N. 1., assignor to The Maltbie Chemical Company, Newark, N. 1., a corporation of New Jersey No Drawing. Application January I; 1935, Serial No. 705
4 Claims. (CL 16'l63) This invention relates to medicaments or No. 1765, and also with that kno as Nopco dressings for the treatment of burns by the ap- CT 2F.
plication of tannic acid, the value of which for The relative amounts of the two oils needed the purpose is now widely recognized. One obto give a. desired easy emulsification can be read- 5 ject of the invention is to provide a tannic acid ily found by trial, but it can be said that in gen- 5' medicament, preferably in the form of a noneral, using Nopco oil No. 1216 (sperm) and Nopdrying ointment which can be easily applied to co oil CT 2F (petroleum oil) or acid Turkey-red the injured surface with the assurance that the oil, a ratio, by weight, of about 3:2 has been tannic 'acidwill be quickly. efiective. Another .fo'und satisfactory.
object is to provide a tannic acid ointment which An important advantage of the use of the mix- 10 will permit bandages to be removed from the time of sulphonated oils is that the resulting l burned area without pain or injury to the unmenstruum can carry a large enough amount derlying tissues. Afurther object is to provide a of bland ingredients, solid and liquid, to protannic acid ointment which can itself be reduce an ointment of smooth texture, of summoved from the burned surface by the use of cient softness for easy application, and yet of 15 water alone. To these and other ends the insufflcient viscosity to remain in 'place well at the vention comprises the novel composition of matbody temperature of the burned surface,and ter hereinafter described. still leave the ointment readily emulsifiable; and
An important feature of the invention is the this without using a large amount of the emuluse of a base or menstruum which is readily sifiable menstruum. Thus the bland ingree 2o emulsifiable, in water, preferably spontaneousdients,consisting of, say, neutral white parafly, so that an ointment which contains a wax fin oil of medium viscosity, white wax, and solid will not be repelled by a watery exudate of the paraflin,may constitute more than fifty per burned surface but will diffuse in the same and cent of the whole ointment, by weight, and the thereby bring the tannic acid quickly into consulphonated oil menstruum no more than fif- 25 tact with the injured tissue. The'mcst effective teen per cent, and Still give d a nt h v n emulsifying agent for the purpose is sulphonated the desirable therapeutic and physical properoil, and I have found that for the best results the ties referred to. Using the three bland ingreinterfacial surface tension of the oil-wax and dientsnamed, with the sulphonated oil ranging water interface should be well below 0.5 dyne from about 12:9 25 per cent and a wax (bees- 30 per centimeter at about 65 C. I have also found wax and solid 'paraflin) content of about 23 per that the desired low interfacial surface tension Cent, the paraflln oil may vary from about 30 is best obtained by the use of a mixture of sulto 40 per c n depending on e viscosity phonated oils, of different surface activities, in sired. If white wax is used without solid p such proportions that the net tension, so to fin a little borax, say .75 to 1 per cent, may be 35 speak, is such as will give the desired capability added to assist in emulsiflcation, but borax tends of easy, preferably spontaneous, emulsiflcation. t make t Ointment, gritty when Solid Paraffin Particularly good results have been obtained in is Present that direction by the use of a sulphonated oil Another advantage of the emulsiflable mencontaining a substantial amount of higher fatty ltruum or base is that if the ointment carries an 40 (wax) alcohol or alcohols, with only a small antiseptic the latter will also be brought into the amount of glycerol or giyceride, for instance most. efiective contact with the injured tissues, sulphonated sperm oil, of which the oil on the along with the tannic acid. So, also, a local market with the trade name Nopco No, 1216 anesthetic or analgesic. As an antiseptic a 4,5 is a good example. The sulphonated sperm oil creosote or phenolic derivative may be used to should be neutral.- The other oil may be a suladva ta p a y amyl m t cresol, a d as phonated petroleum oil, preferably about the an analgesicIprefer p-ethyl aminobenzoate, also same as ordinary glycerin in viscosity, or a sulknown as benzocaine, but any other compatible phonated vegetable oil, for example sulphonated substance of like properties may be used for the castor oil (commonly known as Turkey-red oil) purpose. 50 which contains a relatively large amount of glyc- A further advantage of the quick emulsifying eride and little if any of the higher alcohols. property of the ointment is that it makes a rela- When Turkey-red oil is employed it may be acid tively small tannic acid content as effective as a in reaction. For the second oil good results have much larger amount in an unctuous dressing of been obtained with the grade known as Nopco the usual character. If the ointment emulsifies 66 Gay.
readily in the aqueous exudate of the burned surface the tannic acid is brought quickly into con! tact with the injured tissues and tanning occurs rapidly. On the other hand, if the emulsification is slow, only the tannic acid in the contiguous layer of the ointment reaches the burned surface quickly, so that unless this layer carries a relatively large amount of tannic acid the desired tanning is delayed. With a sulphonated oil content of about 15 per cent and bland ingredientsvabout 55 per cent, a tannic acid content of 5 of an aqueous solution of about percent concentration. A relatively low water content, say 15 to per cent, is' desirable, as the water is then so well surrounded by the unctuous or oily material that the loss of water .by evaporation after the dressing is applied to the burn is minimized and the ointment does not become dry or stiff.
The preferred formula for theointment is the following, which has been found to be thoroughly efficient:
. I Y Percent sulphonated oil-- Neutral sperm'oil. 8.6 Neutral petroleum oil or acid 14.85 Turkey-red bi] 6.25 Bland ingredients- 1' White paraffin oil, medium 33 Solid 'parailln, melting point v I 55.9 60 C 13.9 White wax (beeswax) 9. f Tannic acid, technical '17 Water 21.2 Amyl meta cresol, 0.04 p-ethyl aminobenzoate (benzo- 1.04 caine).. -Q 1 V In compounding the ointment the sulphonated oil component bland ingredients are heated together to about 0., with stirring.
-When the mix is homogenous thev 'amyl meta cresol is stirred in,.after which thetannic acid solution, at about 0., is-added slowly, with constant stirring. When the mass has partly cooled the benzocaine is added, the stirring being continued until the ointment has cooled to about 30 C., after which it is allowed to set.
The ointment may be packaged in collapsible be employed if the blackening incident to simultaneous contact with metal and air is not objectionable. I
It is to be understood that the invention is not limited to the specific details described above but may be embodied inother forms without departure from its spirit as defined by the following claims:
I claim:
1. An ointment for the treatment of burns, containing tannic acid in aqueous solution, and a sulphonated oil menstruum comprising neutral sulphonated sperm oil and neutral sulphonated petroleum oil in the ratio, by weight, of about 3:2, and in total amount to render the ointment spontaneously diflusible in water.
2. An ointment for the treatment of burns, containing tannic acid in aqueous solution, and
a sulphonated oil menstruum comprising neutral sulphonated sperm oil and acid sulphonated castor oil in the ratio, by weight, of about 3:2, and in total amount adapted to render the ointment spontaneously diflusible in water.
3. A tannic acid ointment for the treatment of burns, which contains tannic acid in aqueous solution, and which also contains a sulphonated oil menstruum, giving an oil-water interfacial surface tension less than 0.5 dyne per centimeter,
in amount rendering the ointment spontaneously difl'usible into water, and which ointment contains an ointment base. v
4. A tannic acid ointment for the treatment.
of burns, which contains tannic acid in aqueous solution, in a menstruum containing sulphonated oils of different oil-water interfaclal surface tensions, proportioned to give together an oil-water interfacial surface tension less than 0.5 dyne per centimeter and in-amount rendering the ointment spontaneously diflusible in water, one of said oils containing a higher fatty alcohol and the other substantially free from such alcohols, and which ointment contains an ointment base.
- RUSSEL J. FOSBINDER.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US705A US2056779A (en) | 1935-01-07 | 1935-01-07 | Medicament for the treatment of burns |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US705A US2056779A (en) | 1935-01-07 | 1935-01-07 | Medicament for the treatment of burns |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2056779A true US2056779A (en) | 1936-10-06 |
Family
ID=21692677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US705A Expired - Lifetime US2056779A (en) | 1935-01-07 | 1935-01-07 | Medicament for the treatment of burns |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2056779A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2539483A (en) * | 1945-03-28 | 1951-01-30 | Simon L Ruskin | Urea ascorbate and complexes containing the same and process for their manufacture |
-
1935
- 1935-01-07 US US705A patent/US2056779A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2539483A (en) * | 1945-03-28 | 1951-01-30 | Simon L Ruskin | Urea ascorbate and complexes containing the same and process for their manufacture |
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