US20230172614A1 - Aneurysm treatment with pushable ball segment - Google Patents
Aneurysm treatment with pushable ball segment Download PDFInfo
- Publication number
- US20230172614A1 US20230172614A1 US18/101,630 US202318101630A US2023172614A1 US 20230172614 A1 US20230172614 A1 US 20230172614A1 US 202318101630 A US202318101630 A US 202318101630A US 2023172614 A1 US2023172614 A1 US 2023172614A1
- Authority
- US
- United States
- Prior art keywords
- aneurysm
- segment
- tubular
- braid
- inversion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010002329 Aneurysm Diseases 0.000 title claims abstract description 243
- 238000011282 treatment Methods 0.000 title description 4
- 239000007943 implant Substances 0.000 claims abstract description 154
- 238000000034 method Methods 0.000 claims abstract description 63
- 238000007493 shaping process Methods 0.000 claims description 32
- 239000010410 layer Substances 0.000 claims description 18
- 210000004204 blood vessel Anatomy 0.000 claims description 12
- 239000002356 single layer Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 230000009977 dual effect Effects 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 description 10
- 239000002355 dual-layer Substances 0.000 description 10
- 230000003073 embolic effect Effects 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000012986 modification Methods 0.000 description 6
- 230000004048 modification Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 210000003484 anatomy Anatomy 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 210000005166 vasculature Anatomy 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000005056 compaction Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 208000022211 Arteriovenous Malformations Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 238000012276 Endovascular treatment Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000005744 arteriovenous malformation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
Definitions
- the present invention generally relates to medical instruments, and more particularly, to embolic implants for aneurysm therapy.
- Aneurysms can be complicated and difficult to treat. For example, treatment access may be limited or unavailable when an aneurysm is located proximate critical tissues. Such factors are of particular concern with cranial aneurysms due to the brain tissue surrounding cranial vessels and the corresponding limited treatment access.
- occlusive devices have typically incorporated multiple embolic coils that are delivered to the vasculature using microcatheter delivery systems.
- embolic coils that are delivered to the vasculature using microcatheter delivery systems.
- a delivery catheter with embolic coils is typically first inserted into non-cranial vasculature through a femoral artery in the hip or groin area. Thereafter, the catheter is guided to a location of interest within the cranium. The sac of the aneurysm can then be filled with the embolic material to create a thrombotic mass that protects the arterial walls from blood flow and related pressure.
- occlusive devices do have certain shortcomings, including mass effect, which can cause compression on the brain and its nerves.
- embolic coils delivered to the neck of the aneurysm can potentially have the adverse effect of impeding the flow of blood in the adjoining blood vessel, particularly if the entrance is overpacked. Conversely, if the entrance is insufficiently packed, blood flow can persist into the aneurysm. Treating certain aneurysm morphology (e.g. wide neck, bifurcation, etc.) can require ancillary devices such a stents or balloons to support the coil mass and obtain the desired packing density. Once implanted, the coils cannot easily be retracted or repositioned.
- embolic coils do not always effectively treat aneurysms as aneurysms treated with multiple coils often recanalize or compact because of poor coiling, lack of coverage across the aneurysm neck, blood flow, or large aneurysm size.
- neck-occlusive approaches endeavors to deliver and treat the entrance or “neck” of the aneurysm.
- neck approaches, by minimizing blood flow across the neck, a cessation of flow into the aneurysm may be achieved.
- the neck plane is an imaginary surface where the inner most layer of the parent wall would be but for the aneurysm.
- neck-occlusive approaches such as implanting a flow impeding device in the parent vessel, are not without drawbacks. Such an approach may impede blood flow into peripheral blood vessels while blocking the aneurysm neck in the parent vessel. Impeding flow to the peripheral blood vessel can unintentionally lead to severe damage if the openings of the vessels are blocked.
- tubular braided implants have the potential to easily, accurately, and safely treat an aneurysm or other arterio-venous malformation in a parent vessel without blocking flow into perforator vessels communicating with the parent vessel.
- tubular braided implants are a newer technology, and there is therefore capacity for improved geometries, configurations, delivery systems, etc. for the tubular braided implants.
- tubular braided implants can require unique delivery systems to prevent the braid from inverting or abrading when pushed through a microcatheter, and some simple delivery systems that push embolic coils through microcatheters from their proximal end may not be effective to deliver tubular braids.
- the implant can secure within an aneurysm sac and occlude at least a majority of the aneurysm's neck.
- the implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted.
- the implant can also have a retractable ball segment at the proximal end of the device made of the same braid that can be heat treated into an ellipsoid shape.
- the retractable ball segment can be movable from a position outside the aneurysm to a position at least partially enclosed within the implant to increase or decrease the height of the implant relative to the aneurysm or better conform the implant to the neck of the aneurysm.
- the dual layer can be shaped by expanding it radially, and the dual layer can be pressed distally into a first portion of the tubular braid already within the aneurysm.
- the first portion of the tubular braid can be moved towards the distal portion of an aneurysm wall so that the implant can partially or completely occlude an aneurysm neck.
- Pushing the dual layer into the first portion of the braid can help conform the implant to the shape of the aneurysm and resist compaction.
- the dual layer when expanded radially and pressed into the first portion of the braid also can provide additional coverage at the neck of the aneurysm to increase thrombosis.
- the dual layer can also be placed within the aneurysm sac with only a detachment point external to the sac.
- the tubular braid can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted.
- tubular braid can be shaped to a delivery shape that is extended to a single layer of tubular braid having a compressed circumference/diameter sized to be delivered through the microcatheter.
- the implant before the implant is released from the delivery system, the implant can be partially or fully retracted into the microcatheter and repositioned.
- An example method for forming an occlusive device to treat an aneurysm can include one or more of the following steps presented in no particular order, and the method can include additional steps not included here.
- An implant with a tubular braid, an open end, and a pinched end can be selected.
- the tubular braid can be shaped to a predetermined shape. Shaping the tubular braid to a predetermined shape can also include further steps. These steps can include inverting the tubular braid to form a distal inversion.
- the tubular braid can also be inverted to form a proximal inversion by moving the open end over at least a portion of the braid.
- a first segment of the tubular braid extending between the open end and the proximal inversion can be shaped.
- a second segment of the tubular braid extending between the proximal inversion and the distal inversion can be shaped.
- the open end can be positioned to encircle the second segment.
- a third segment extending from the distal inversion to the proximal inversion can be shaped.
- the second segment can be positioned to surround the third segment.
- a fourth segment of the tubular braid extending from the third segment radially outward from a central axis to cross the proximal inversion can be shaped and can fold and converge at the pinched end.
- the fourth segment can be positioned near the neck of an aneurysm.
- An example method for treating an aneurysm can include one or more of the following steps presented in no particular order, and the method can include additional steps not included here.
- a first portion of a tubular braided implant which can have a tubular braid, an open end, and a pinched end, can be positioned within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac.
- the first portion can have one or more inversions.
- a second portion of the tubular braided implant can be expanded radially to occlude a majority of a neck of the aneurysm.
- the second portion can be pressed distally into the first portion.
- the first portion of the tubular braided implant can be moved toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- expanding the second portion of the tubular braided implant can include positioning a fold in the second segment to define a substantially circular perimeter of the second portion and compressing the second portion along a central axis of the tubular braided implant such that the second portion can have a substantially circular shape having an area and two layers of braid over a majority of the area of the substantially circular shape.
- positioning the first portion of the tubular braided implant can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion.
- positioning the first portion of the tubular braided implant can further involve positioning a proximal inversion near the neck of the aneurysm and positioning a distal inversion approximate the distal portion of the aneurysm wall.
- positioning the first portion of the tubular braided implant can further involve positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose at least a portion of a wall of the aneurysm within the aneurysm's sac, and shaping a second segment of the tubular braid such that the first segment provides an outwardly radial force in a plane defining a boundary between the aneurysm and blood vessel branches, the force sufficient to appose the first segment to walls of the aneurysm.
- pressing the second portion distally into the first portion can further involve pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant.
- the tubular braid can include two inversions, a pinched end, and an open end.
- the tubular braid can also include four segments. The first segment can extend from the open end of the tubular braid to a proximal inversion. The second segment can be at least partially encircled by the open end and can extend from the proximal inversion to a distal inversion.
- the third segment can then be surrounded by the second segment and extend from the distal inversion to a ball segment.
- the ball segment can extend from a proximal end of the third segment and be shaped radially outward from a central axis of the tubular braid to form a substantially ellipsoid shape and converge at the pinched end.
- This form can be heat treated with a mold to set the implant into the predetermined shape, and once the mold is removed, the predetermined shape is formed.
- This example implant can then be implanted within an aneurysm.
- the aneurysm can have a range of different heights.
- the braid can have an outer layer corresponding to the first segment of the predetermined shape and positioned to contact an aneurysm wall.
- the braid can also have a proximal inversion corresponding to the proximal inversion of the predetermined shape positioned near an aneurysm neck, and a sack corresponding to the second segment of the predetermined shape that apposes the outer layer.
- a distal inversion can correspond to the distal inversion of the predetermined shape
- a third segment can correspond to the third segment in the predetermined shape.
- the first, second, and third segments can make up a first portion of the braid.
- the braid can also have a ball segment corresponding to the ball segment of the predetermined shape and extending from the third segment radially outward from a central axis to form a substantially ellipsoid shape and converge at the pinched end.
- the ball segment can be pressed distally into the first portion of the tubular braid.
- the ball segment When implanted, the ball segment can be positioned external to the aneurysm sac, extending across the aneurysm neck.
- the ball segment can occlude at least a portion of the aneurysm neck.
- the first portion of the tubular braid By pressing the ball segment into the first portion of the tubular braid, the first portion of the tubular braid can be moved towards the distal portion of an aneurysm wall. Pushing the ball segment into the first portion of the braid can appose the proximal inversion to provide a radially outward force against the proximal inversion so that the tubular braid contacts a wall of the aneurysm approximate a neck of the aneurysm.
- pushing the ball segment distally into the first portion of the tubular braid can push the third segment distally into the aneurysm towards a distal portion of the aneurysm wall.
- This movement of the third segment can be independent of distal movement of the outer layer and/or sack. This can extend the height of the implant to better conform to the height of the aneurysm.
- At least a portion of the ball segment can be enclosed by the sack.
- At least a portion of the ball segment can be positioned external to the sack.
- An example method for treating an aneurysm can include positioning a first portion of a tubular braided implant, the tubular braided implant having a tubular braid, an open end, and a pinched end, to circumferentially appose the aneurysm's walls.
- the first portion can include one or more inversions, including a distal inversion approximate a distal portion of the aneurysm wall.
- This example method can further include expanding a second portion of the tubular braided implant in connection with the first portion of the tubular braided implant radially to occlude a majority of the neck of the aneurysm.
- the second portion can be pressed distally into the first portion to provide a radial force against the first portion towards the aneurysm wall approximate the neck of the aneurysm in a plane defining a boundary between the aneurysm and blood vessel branches.
- the distal inversion can be moved toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- Another example method for forming an occlusive device to treat an aneurysm can include the step of inverting a tubular braid comprising an open end and a pinched end to form a distal inversion.
- the method can further involve inverting the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid.
- the method can also include shaping a first segment of the tubular braid extending between the open end and the proximal inversion.
- the example method can further include shaping a second segment of the tubular braid extending between the proximal inversion and the distal inversion.
- the method can also include positioning the open end to encircle the second segment.
- the method can further involve shaping a third segment extending from the distal inversion to the pinched end. Then, the method can include positioning the second segment to surround the third segment. The method can further include shaping a ball segment of the tubular braid extending from the third segment radially outward from a central axis to form a substantially ellipsoid and converge at the pinched end. The method can also involve applying a mold to the ball segment of the tubular braid and treating the ball segment with heat to conform the ball segment to a formed shape, the ball segment movable along a central axis of the tubular braid.
- FIG. 1 A is an illustration of an example implant having a tubular braid in a predetermined shape according to aspects of the present invention
- FIG. 1 B is an illustration of the example implant with the tubular braid in a first implanted shape according to aspects of the present invention
- FIGS. 2 A through 2 I are illustrations of an implant having a tubular braid that expands to an implanted shape similar to as illustrated in FIG. 1 B as the tubular braid exits a microcatheter according to aspects of the present inventions;
- FIGS. 3 A through 3 B are flow diagrams for a method of forming an occlusive device to treat an aneurysm
- FIGS. 4 A through 4 B are flow diagrams for a method for treating an aneurysm
- FIGS. 5 A through 5 B are illustrations of an example implant being formed into a predetermined shape according to aspects of the present invention.
- FIGS. 6 A through 6 C are illustrations of an implant having a tubular braid in an implanted shape according to aspects of the present invention.
- FIG. 7 is a flow diagram for a method of treating an aneurysm.
- FIG. 8 is a flow diagram for a method of forming an occlusive device to treat an aneurysm.
- Examples presented herein generally include a braided implant that can secure within an aneurysm sac and occlude a majority of the aneurysm's neck.
- the implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted.
- the implant can include a single layer of braid (e.g. a braid that can be extended to form a single layer tube) heat treated into multiple layers with retractable dual layer at the proximal end of the tubular braid. When compressed, the implant can be sufficiently short to mitigate friction forces produced when the implant is delivered unsheathed through the microcatheter.
- a first portion of the tubular braid can be positioned in an aneurysm, after which the retractable dual layer can be deployed from the microcatheter and pushed onto the first portion of the tubular braid.
- This configuration provides three layers of braid at the neck of the aneurysm.
- the dual layer can potentially cover any gap between the first portion of implanted tubular braid and the aneurysm neck, and can potentially increase metal coverage, decrease porosity of the implant, and increase stasis and blood flow diversion at the neck of the aneurysm to promote the sealing and healing of the aneurysm compared a similarly shaped braided implant lacking the dual layer.
- the entire implant can be retractable until a desired position is achieved.
- FIGS. 1 A and 1 B are illustrations of an example braided implant 100 that can have a predetermined shape as shown in FIG. 1 A and a distinct implanted shape as illustrated in FIG. 1 B .
- the implant 100 can treat a range of aneurysm sizes.
- the implant 100 can include a tubular braid 110 having an open end 114 and a pinched end 112 .
- the implant 100 can include a connection and detachment feature 150 (referred to equivalently as “connection feature” and “detachment feature” herein) attached to the braid 110 at the pinched end 112 .
- the pinched end 112 can include a marker band and/or soldered point with visibility, and/or the connection feature 150 can include radiopaque material.
- the tubular braid 110 can be formed in the predetermined shape ( FIG. 1 A ), collapsed for delivery through a microcatheter, attached to a delivery system at connection feature 150 , and implanted in an implanted shape such as the one shown in FIG. 1 B .
- the tubular braid 110 when in the predetermined shape, can include two inversions 122 , 124 , a pinched end 112 , and an open end 114 .
- the tubular braid 110 can include four segments, 142 , 144 , 146 , and 152 .
- the first segment 142 can extend from the open end 114 of the tubular braid 110 to a proximal inversion 122 .
- the second segment 144 can be encircled by the open end 114 and extend from the proximal inversion 122 to a distal inversion 124 .
- the third segment 146 can be surrounded by the second segment 144 and extend from the distal inversion 124 to the proximal inversion 122 .
- the first segment 142 , second segment 144 , and third segment 146 can form the first portion of the tubular braid 110 .
- the fourth segment 152 can extend from the third segment 146 radially outward from a central axis to cross the proximal inversion 122 , fold, and converge at the pinched end 112 .
- the fourth segment 152 can be partially encircled by the proximal inversion 122 .
- the tubular braid 110 When in the predetermined shape, the tubular braid 110 can be substantially radially symmetrical about a central vertical axis.
- the detachment feature 150 is illustrated in FIG. 1 A as a flat key that can be used with a mechanical delivery implant system (not pictured).
- the tubular braid 110 can be formed into the predetermined shape by first inverting the braid outwardly to separate the third segment 146 from the second segment 144 with a distal inversion 124 . Then, the second segment 144 can be shaped over a form to produce the substantially “S” shaped profile illustrated in FIG. 1 A . Next, the braid 110 can be inverted outwardly again to separate the second segment 144 from the first segment 142 with a proximal inversion 122 .
- the fourth segment 152 can be shaped by expanding the fourth segment 152 radially.
- the fourth segment 152 can be pressed distally into the first portion of the tubular braid 110 . It can also be advantageous to minimize a neck opening 126 defined by the lower extension of the “S” shape of second segment 144 to maximize occlusion of an aneurysm neck when the implant 100 is implanted.
- the tubular braid 110 can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted.
- the fourth segment 152 can comprise a diameter D 1 greater than or approximately equal to a maximum diameter D 2 of the first segment 142 .
- the fourth segment 152 can comprise a diameter D 1 lesser than a maximum diameter D 2 of the first segment 142 .
- the second segment 144 can form a sack, and at least a portion of the third segment 146 can positioned within the sack and at least a portion of the fourth segment 152 can be positioned external to the sack.
- the fourth segment 152 when implanted, can be positioned external to the aneurysm sac, extending across the aneurysm neck 16 .
- the fourth segment 152 can appose vasculature walls surrounding the aneurysm neck 16 when implanted.
- the shaped fourth segment 152 can also be placed within the aneurysm sac.
- the detachment feature 150 can be implanted centrally in the aneurysm neck 16 .
- the detachment feature 150 can be positioned external to the sac 12 .
- the tubular braid 110 in the implanted shape can be radially or vertically compressed or extended compared to the predetermined shape.
- the braid 110 when in the implanted shape, can have an outer layer 142 a corresponding to the first segment 142 of the predetermined shape and positioned to contact an aneurysm wall 14 of the aneurysm 10 , a proximal inversion 122 a corresponding to the proximal inversion 122 of the predetermined shape and positioned to be placed approximate a neck 16 of the aneurysm 10 , and a sack 144 a corresponding to the second segment 144 of the predetermined shape and positioned to appose a portion of the aneurysm wall 14 of the aneurysm 10 and apposing the outer layer 142 a.
- a distal inversion 124 a can correspond to the distal inversion 124 of the predetermined shape
- a third segment 146 a can correspond to the third segment 146 in the predetermined shape
- the braid 110 can also have a fourth segment 152 a corresponding to the fourth segment 152 of the predetermined shape and extending from the third segment 146 a radially outward from a central axis to cross the proximal inversion 122 a, fold, and converge at the pinched end 112 .
- the fourth segment 152 a can be pressed distally into the first portion of the tubular braid 110 .
- the first portion 142 a, 144 a, 146 a of the tubular braid 110 can be moved towards the distal portion of an aneurysm wall 15 to occlude a portion of the neck 16 of the aneurysm 10 .
- Pushing the fourth segment 152 a into the first portion of the braid 110 can help conform the implant 100 to the shape of the aneurysm 10 and resist compaction.
- the fourth segment 152 a when expanded radially and pressed into the first portion of the braid 110 also can provide additional coverage at the neck 16 of the aneurysm 10 to increase thrombosis and seal the aneurysm 10 .
- the fourth segment 152 a When the fourth segment 152 a is pressed into the first portion of the braid 110 , three layers of braid are present at the neck of the aneurysm.
- the fourth segment 152 a can cover spatial gaps between the first portion of implanted tubular braid 110 and the aneurysm neck 16 , and can potentially increase metal coverage, decrease porosity of the implant 100 , and increase stasis and blood flow diversion at the neck 16 of the aneurysm 10 to promote the sealing and thrombosis of the aneurysm 10 .
- the fourth segment 152 a can be shaped to occlude the majority of an aneurysm neck 16 when the device 100 is implanted.
- the fourth segment 152 a can be shaped to completely occlude an aneurysm neck 16 when the device 100 is implanted.
- the fourth segment 152 a can comprise a diameter D 1 greater than or approximately equal to a maximum diameter D 2 of the first segment 142 a.
- the fourth segment 152 a can comprise a diameter D 1 lesser than a maximum diameter D 2 of the first segment 142 a.
- the second segment 144 a can form a sack, and at least a portion of the third segment 146 a can be positioned within the sack and at least a portion of the fourth segment 152 a can be positioned external to the sack.
- the shaped fourth segment 152 a can also be placed within the aneurysm sac 12 with only the detachment point 150 external to the sac 12 .
- FIGS. 2 A through 2 I are illustrations of an example implant 100 having a braid 110 expanding to an implanted shape that is based on a predetermined shape and the anatomy of the aneurysm and nearby blood vessel as the braid 110 exits a microcatheter 600 .
- the implant 100 has a predetermined shape similar to the shape illustrated in FIG. 1 A .
- the braid 110 can be shaped to a delivery shape that is extended to a single layer of tubular braid having a compressed circumference/diameter sized to be delivered through the microcatheter 600 and a length L.
- the length L of a specific braid 110 can be tailored based on the size and shape of the aneurysm being treated.
- the length L can be approximately 1 inch in length.
- the detachment feature 150 can be attached to a delivery system at a proximal end of the implant 100 , the pinched end 112 can be positioned near the proximal end of the implant 100 , and the open end 114 can define the distal end of the implant 100 .
- Collapsing the braid 110 to a single layer tube can result in a braid 110 that has a sufficiently small diameter and a sufficiently short length L to mitigate effects of friction force on the braid 110 when it is delivered through the microcatheter, allowing the braid 110 to be delivered unsheathed in some applications
- the implant 100 can be delivered to an aneurysm 10 through the microcatheter 600 .
- the open end 114 can be positioned to exit the microcatheter 600 before any other portion of the braid 110 exits the microcatheter.
- the open end 114 can expand within the aneurysm sac 12 as it exits the microcatheter 600 .
- the illustrated aneurysm 10 is positioned at a bifurcation including a stem blood vessel 700 and two branch vessels 702 , and the microcatheter 600 is illustrated being delivered through the stem blood vessel 700 .
- the implant could be delivered to an aneurysm on a sidewall of a blood vessel through a curved microcatheter, and such a procedure is intended to be embraced by the scope of the present disclosure.
- the distal portion of the braid 110 can continue to expand radially within the aneurysm sac 12 as it exits the microcatheter 600 .
- the braid 110 can appose the aneurysm wall 14 and conform approximate the aneurysm neck 16 .
- the aneurysm 10 being treated can have a diameter that is less than the outer diameter of the tubular braid 110 in the predetermined shape so that the braid 110 tends to expand outwardly, providing a force against the aneurysm wall 14 and sealing approximate the perimeter of the aneurysm neck 16 .
- the braid 110 can form the proximal inversion 122 a defining the first segment 142 a as the braid 110 is further pushed out of the microcatheter 600 .
- the proximal inversion 122 a can be positioned approximate the aneurysm neck 16 .
- the distal inversion 124 a defining the second segment 144 a can also begin to form as the braid 110 is pushed out of the microcatheter 600 .
- the “S” shape of the second segment 144 a can begin to form as the braid 110 is further pushed from the microcatheter 600 .
- the fourth segment 152 a can radially expand outside the aneurysm 10 as the distal portion of the braid 110 continues to exit the microcatheter 600 .
- the fourth segment 152 a can then be compressed distally as it continues to radially expand, compressing the fourth segment 152 a up into the first portion of the braid 110 .
- the fourth segment 152 a can be compressed distally into the first portion of the braid 110 , at least partially occluding the neck 16 of the aneurysm 10 and the neck opening 126 .
- the pinched end 112 and/or the detachment point 150 can remain external to the aneurysm sac once the fourth segment 152 a has reached its final expanded and compressed state.
- the fourth segment 152 a when compressed can be compressed to a minimal thickness as to not become an obstruction to the surrounding blood vessels.
- the implant 100 Before the implant 100 is released from the delivery system, the implant 100 can be partially or fully retracted into the microcatheter 600 and repositioned.
- FIG. 3 A is a flow diagram for a method 300 for forming an occlusive device to treat an aneurysm 10 .
- Step 310 includes selecting an implant comprising a tubular braid, an open end, and a pinched end.
- Step 320 includes shaping the tubular braid to a predetermined shape, such as the one illustrated in FIG. 1 A .
- step 320 can further comprise additional steps.
- Step 322 includes inverting the tubular braid to form a distal inversion.
- Step 324 inverts the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid.
- Step 326 includes shaping a first segment of the tubular braid extending between the open end and the proximal inversion.
- Step 328 shapes a second segment of the tubular braid extending between the proximal inversion and the distal inversion.
- Step 330 includes positioning the open end to encircle the second segment.
- Step 332 shapes a third segment extending from the distal inversion to the proximal inversion.
- Step 334 includes positioning the second segment to surround the third segment.
- Step 336 shapes a fourth segment of the tubular braid extending from the third segment radially outward from a central axis to cross the proximal inversion, fold inwardly toward the central axis, and converge at the pinched end.
- Step 338 includes positioning the fourth segment approximate a neck of an aneurysm.
- step 320 of shaping the tubular braid to the predetermined shape can further include shaping the fourth segment to comprise a diameter greater than or approximately equal to a maximum diameter of the first segment.
- the step 320 of shaping the tubular braid to the predetermined shape can further include shaping the fourth segment to a diameter lesser than a maximum diameter of the first segment.
- the method 300 can further include shaping the tubular braided implant to a delivery shape sized to traverse a lumen of a microcatheter.
- FIG. 4 A is a flow diagram for a method 400 for a method for treating an aneurysm 10 .
- Step 410 positions a first portion of a tubular braided implant, the tubular braided implant comprising a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac.
- the first portion can include one or more inversions.
- Step 420 includes expanding a second portion of the tubular braided implant radially to occlude a majority of a neck of the aneurysm.
- Step 430 presses the second portion distally into the first portion.
- Step 440 includes moving the first portion of the tubular braided implant toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- step 420 can further include step 422 , which includes positioning a fold in the second segment to define a substantially circular perimeter of the second portion.
- step 420 can additionally, or alternatively include step 424 , which includes compressing the second portion along a central axis of the tubular braided implant such that the second portion comprises a substantially circular shape having an area and the second portion comprises two layers of braid over a majority of the area of the substantially circular shape.
- Step 410 can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion.
- Step 410 can further include positioning a proximal inversion in the first portion of the tubular braided implant approximate the neck of an aneurysm and positioning a distal inversion in the first portion of the tubular braided implant approximate the distal portion of the aneurysm wall.
- Step 410 can further include positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose an at least a portion of a wall of the aneurysm within the aneurysm's sac, and shaping a second segment of the tubular braid such that the first segment provides an outwardly radial force in a plane defining a boundary between the aneurysm and blood vessel branches, the force sufficient to appose the first segment to walls of the aneurysm.
- Step 430 can further include pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant.
- Step 440 can further include moving the distal inversion in the first portion of the tubular braided implant toward the distal portion of the aneurysm wall.
- the method 400 can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion.
- the method 400 can further include retracting the tubular braid until a desired position is achieved relative to the aneurysm.
- the method 400 can further comprise shaping the tubular braided implant to a delivery shape sized to traverse a lumen of a microcatheter.
- FIGS. 5 A through 5 B are illustrations of an example braided implant 200 as it is formed into a predetermined shape ( FIG. 5 B ).
- the implant 200 can treat a range of aneurysm sizes.
- the implant 200 can include a tubular braid 210 having an open end 214 and a pinched end 212 , similar to FIGS. 1 A and 1 B .
- the tubular braid 210 can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted.
- the tubular braid 210 When in the predetermined shape, the tubular braid 210 can be substantially radially symmetrical about a central vertical axis.
- the implant 200 can include a connection and detachment feature 150 as illustrated in prior figures.
- the pinched end 212 can include a marker band and/or soldered point with visibility, and/or the connection feature 150 can include radiopaque material.
- the tubular braid 210 can be formed in the predetermined shape ( FIG. 5 B ), collapsed to a delivery shape with a single layer of braid 210 for delivery through a microcatheter similar to FIG. 2 A , attached to a delivery system at connection feature 150 , and implanted in an implanted shape such as the ones shown in FIGS. 6 A- 6 C in a manner similar to the delivery described in FIGS. 2 A through 2 F .
- the tubular braid 210 can include two inversions, 222 , 224 , a pinched end, 212 , and an open end 214 .
- the tubular braid 210 as depicted in FIG. 5 A can include four segments, 242 , 244 , 246 , and 248 .
- the first segment 242 can extend from the open end 214 of the tubular braid 210 to a proximal inversion 222 .
- the second segment 244 can be encircled by the open end 214 and can extend from the proximal inversion 222 to a distal inversion 224 .
- the third segment 246 can be surrounded by the second segment 244 .
- the tubular braid can be formed into a predetermined shape by first inverting the braid 210 outwardly to separate the third segment 246 from the second segment 244 with a distal inversion 224 . Then, the second segment 244 can be shaped over a form or mold. The form can be in the shape of a sack. Next, the braid 210 can be inverted outwardly again to separate the second segment 244 from the first segment 242 with a proximal inversion 222 .
- the third segment 246 can span from the distal inversion 224 to the ball segment 248 .
- the first segment 242 , second segment 244 , and third segment 246 can form a first portion of the tubular braid 210 .
- the ball segment 248 can extend from a proximal portion of the third segment 246 radially outward from a central axis of the tubular braid 210 to form a substantially ellipsoid shape and converge at the pinched end 212 .
- a mold 220 can be applied, and this form wherein the ball segment 248 is shaped can be treated with heat in order to set the predetermined shape as depicted in FIG. 5 B .
- the ball segment 248 can be pressed distally into the first portion of the tubular braid 210 .
- the ball segment 248 can provide a radially outward force to appose the proximal inversion 222 .
- the ball segment 248 can be at least partially enclosed within the second segment 244 distal to the proximal inversion 222 .
- the ball segment 248 can also be fully enclosed within the second segment 244 distal to the proximal inversion 222 .
- the second segment 244 can form a sack, and at least a portion of the third segment 246 can positioned within the sack and at least a portion of the ball segment 248 can be positioned external to the sack.
- the ball segment 248 can occlude at least a portion of the proximal inversion 222 to seal the opening created by the proximal inversion 222 .
- FIGS. 6 A through 6 C are illustrations of an example braided implant 200 implanted within an aneurysm 10 .
- the tubular braid 210 can be radially or vertically compressed or extended compared to the predetermined shape to conform to aneurysms of varying sizes, heights, and shapes. As illustrated in FIG.
- the braid 210 when in the implanted shape in an aneurysm 10 with a height H 1 , the braid 210 can have an outer layer 242 a corresponding to the first segment 242 of the predetermined shape and positioned to contact an aneurysm wall 14 of the aneurysm 10 , a proximal inversion 222 a corresponding to the proximal inversion 222 of the predetermined shape and positioned to be placed approximate a neck 16 of the aneurysm 10 , and a sack 244 a corresponding to the second segment 244 of the predetermined shape and positioned to appose the outer layer 242 a.
- a distal inversion 224 a can correspond to the distal inversion 224 of the predetermined shape, and a third segment 246 a can correspond to the third segment 246 in the predetermined shape.
- the braid 210 can also have a ball segment 248 a corresponding to the ball segment 248 of the predetermined shape and extending from the third segment 246 a radially outward from a central axis to form a substantially ellipsoid shape and converge at the pinched end 212 .
- the ball segment 248 a can be pressed distally into the first portion of the tubular braid 210 .
- Pressing the ball segment 248 a distally into the first portion of the tubular braid 210 can result in multiple layers of braid 210 seated at the neck 16 of the aneurysm 10 . These multiple layers of braid 210 can inhibit blood flow into the aneurysm 10 by better occluding the aneurysm neck 16 , by better occluding the channel formed by the proximal inversion 222 a, or both.
- the ball segment 248 a when implanted, can be positioned external to the aneurysm 10 , extending across the aneurysm neck 16 .
- the ball segment 248 a can occlude at least a portion of the aneurysm neck 16 .
- the ball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a.
- FIG. 6 B depicts an implant 200 in an aneurysm 10 with a height H 2 .
- the height H 2 of the aneurysm in FIG. 6 B can be greater than the height H 1 of the aneurysm in FIG. 6 A .
- the first portion 242 a, 244 a, 246 a of the tubular braid 210 can be moved further into the aneurysm 10 towards the distal portion of an aneurysm wall 15 .
- the ball segment 248 a can occlude at least a portion of the neck 16 of the aneurysm 10 .
- the ball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a. Pushing the ball segment 248 a into the first portion of the braid 210 can also appose the proximal inversion 222 to provide a radially outward force against the proximal inversion 222 so that the tubular braid 210 apposes a wall 14 of the aneurysm 10 approximate a neck 16 of the aneurysm 10 .
- pushing the ball segment 248 a distally into the first portion of the tubular braid 210 can push the third segment 246 a distally into the aneurysm towards a distal portion of the aneurysm wall 15 , independent of distal movement of the outer layer 242 a and/or sack 244 a.
- This can extend the height of the implant 200 to better conform to the height of the aneurysm H 2 .
- At least a portion of the ball segment 248 a can be enclosed by the sack 244 a.
- At least a portion of the ball segment 248 a can be positioned external to the sack 244 a.
- the implant 200 can be deployed within an aneurysm with a height H 3 greater than H 1 and H 2 in FIGS. 6 A and 6 B respectively.
- the ball segment 248 a can be pushed distally even further into the first portion of the tubular braid 210 until it is completely enclosed within the sack 244 a.
- the first portion 242 a, 244 a, 246 a of the tubular braid 210 can be moved towards the distal portion of an aneurysm wall 15 .
- FIG. 6 C the implant 200 can be deployed within an aneurysm with a height H 3 greater than H 1 and H 2 in FIGS. 6 A and 6 B respectively.
- the ball segment 248 a can be pushed distally even further into the first portion of the tubular braid 210 until it is completely enclosed within the sack 244 a.
- the first portion 242 a, 244 a, 246 a of the tubular braid 210 can be moved towards the distal portion of an aneurysm wall 15
- pushing the ball segment 248 a distally into the first portion of the tubular braid 210 can push the third segment 246 a distally into the aneurysm towards a distal portion of the aneurysm wall 15 , independent of distal movement of the outer layer 242 a and/or sack 244 a.
- This can extend the height of the implant 200 to better conform to the height of the aneurysm H 3 .
- the ball segment 248 a can occlude at least a portion of the aneurysm neck 16 .
- the ball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a.
- the implant 200 can be used to treat implants of varying heights and widths depending on the positioning of the ball segment 248 relative to the first portion of the braid 210 .
- FIG. 7 is a flow diagram for a method 700 for treating an aneurysm 10 .
- the method 700 can be utilized to treat aneurysms of varying sizes, heights, and shapes with a single device.
- Step 710 positions a first portion of a tubular braided implant, the tubular braided implant having a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac.
- the first portion can include one or more inversions, including a distal inversion approximate a distal portion of the aneurysm wall.
- Step 720 includes expanding a second portion of the tubular braided implant in connection with the first portion of the tubular braided implant radially to occlude a majority of the neck of the aneurysm.
- Step 730 presses the second portion distally into the first portion to provide a radial force against the first portion towards the aneurysm wall approximate the neck of the aneurysm in a plane defining a boundary between the aneurysm and blood vessel branches.
- Step 740 moves the distal inversion toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- the step 710 of positioning the first portion of the tubular braided implant can further include positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, positioning a proximal inversion in the first portion of the tubular braided implant approximate the neck of an aneurysm; and shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose an at least a portion of a wall of the aneurysm within the aneurysm's sac.
- the step 720 of expanding the second portion of the tubular braided implant can further include compressing the second portion along a central axis of the tubular braided implant such that the second portion forms a substantially ellipsoidal shape.
- the step 730 of pressing the second portion distally into the first portion can further include apposing at least a part of the first portion with the second portion to provide an outwardly radial force along a central axis of the tubular braided implant from the second portion to the first portion.
- the step 730 of pressing the second portion distally can also involve pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant until the second portion of the tubular braided implant is at least partially enclosed by the proximal inversion.
- the step 730 of pressing the second portion distally can also disrupt the flow of blood into the aneurysm by placing multiple layers of braid approximate the neck of the aneurysm.
- the method 700 can further include shaping the tubular braided implant to a delivery shape with a single layer of braid sized to traverse a lumen of a microcatheter.
- FIG. 8 is a flow diagram for a method of forming an occlusive device to treat an aneurysm.
- the method can include inverting a tubular braid comprising an open end and a pinched end to form a distal inversion ( 810 ); inverting the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid ( 820 ); shaping a first segment of the tubular braid extending between the open end and the proximal inversion ( 830 ); shaping a second segment of the tubular braid extending between the proximal inversion and the distal inversion ( 840 ); positioning the open end to encircle the second segment ( 850 ); shaping a third segment extending from the distal inversion to the pinched end ( 860 ); positioning the second segment to surround the third segment ( 870 ); shaping a ball segment of the tubular braid extending from the third segment radially outward from a central axis to form a substantially ellip
- the method 800 can further include positioning the first segment, second segment, and third segment within an aneurysm, and advancing the ball segment distally into the proximal inversion. This step of advancing the ball segment distally into the proximal inversion can move the distal inversion towards a distal portion of a wall of the aneurysm, which can conform the device to the height of the aneurysm. In this manner, the device can be used to treat aneurysms of varying heights, shapes, and sizes.
- the method 800 can also include apposing the proximal inversion with at least a portion of the ball segment.
- the method 800 can further include moving the ball segment to a position at least partially enclosed by the second segment distal to the proximal inversion.
- the method 800 can also involve retracting the tubular braid until a desired position is achieved relative to the aneurysm.
- the terms “about” or “approximately” for any numerical values or ranges indicate a suitable dimensional tolerance that allows the part or collection of components to function for its intended purpose as described herein.
- the descriptions contained herein are examples of embodiments of the invention and are not intended in any way to limit the scope of the invention.
- the invention contemplates many variations and modifications of the implant, including: alternative delivery methods, alternative braid materials, alternative means for achieving a desired stiffness/flexibility of braid material, additional structures affixed to the implant (e.g. to aid in anchoring the implant, blood flow diversion, embolism formation, etc.), alternative predetermined braid shapes (e.g. one inversion, three inversions, four inversions, five or more inversions, non-radially symmetric shapes, alternative segment shapes, etc.), alternative implanted shapes, etc.
- the invention contemplates many variations and modifications to constructing the implant to include combinations of the aforementioned variations and modifications of the implant.
- the invention contemplates many variations and modifications of implanting the implant to accommodate combinations of the aforementioned variations and modifications of the implant. Modifications apparent to one of ordinary skill in the art following the teachings of this disclosure are intended to be within the scope of the claims which follow.
Abstract
The present invention provides a braided implant with a retractable dual proximal layer and methods for administering the braided implant to treat aneurysms. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can also have a retractable ball segment at the proximal end of the device made of the same braid that can be heat treated into an ellipsoid shape. The retractable ball segment can be movable from a position outside the aneurysm to a position at least partially enclosed within the implant to increase or decrease the height of the implant relative to the aneurysm or better conform the implant to the neck of the aneurysm.
Description
- This application is a divisional application of U.S. patent application Ser. No. 16/865,165 filed May 1, 2020, which is a continuation-in-part of U.S. patent application Ser. No. 16/853,135 filed Apr. 20, 2020, issued as U.S. Pat. No. 11,497,504 on Nov. 15, 2022, which is a continuation-in-part of U.S. patent application Ser. No. 16/418,199 filed May 21, 2019, issued as 10,653,4725 on May 19, 2020.
- U.S. patent application Ser. No. 16/865,165 filed May 1, 2020, is also a continuation-in-part of U.S. patent application Ser. No. 16/748,877 filed Jan. 22, 2020.
- The contents of all of which are incorporated herein by reference in their entirety.
- The present invention generally relates to medical instruments, and more particularly, to embolic implants for aneurysm therapy.
- Aneurysms can be complicated and difficult to treat. For example, treatment access may be limited or unavailable when an aneurysm is located proximate critical tissues. Such factors are of particular concern with cranial aneurysms due to the brain tissue surrounding cranial vessels and the corresponding limited treatment access.
- Prior solutions have included endovascular treatment access whereby an internal volume of the aneurysm sac is removed or excluded from arterial blood pressure and flow. In this respect, because the interior walls of the aneurysm may continue being subjected to flow of blood and related pressure, aneurysm rupture remains possible.
- Alternative to endovascular or other surgical approaches can include occlusive devices. Such devices have typically incorporated multiple embolic coils that are delivered to the vasculature using microcatheter delivery systems. For example, when treating cranial aneurysms, a delivery catheter with embolic coils is typically first inserted into non-cranial vasculature through a femoral artery in the hip or groin area. Thereafter, the catheter is guided to a location of interest within the cranium. The sac of the aneurysm can then be filled with the embolic material to create a thrombotic mass that protects the arterial walls from blood flow and related pressure. However, such occlusive devices do have certain shortcomings, including mass effect, which can cause compression on the brain and its nerves.
- For example, embolic coils delivered to the neck of the aneurysm can potentially have the adverse effect of impeding the flow of blood in the adjoining blood vessel, particularly if the entrance is overpacked. Conversely, if the entrance is insufficiently packed, blood flow can persist into the aneurysm. Treating certain aneurysm morphology (e.g. wide neck, bifurcation, etc.) can require ancillary devices such a stents or balloons to support the coil mass and obtain the desired packing density. Once implanted, the coils cannot easily be retracted or repositioned. Furthermore, embolic coils do not always effectively treat aneurysms as aneurysms treated with multiple coils often recanalize or compact because of poor coiling, lack of coverage across the aneurysm neck, blood flow, or large aneurysm size.
- Another particular type of occlusive approach endeavors to deliver and treat the entrance or “neck” of the aneurysm. In such “neck” approaches, by minimizing blood flow across the neck, a cessation of flow into the aneurysm may be achieved. It is understood that the neck plane is an imaginary surface where the inner most layer of the parent wall would be but for the aneurysm. However, neck-occlusive approaches, such as implanting a flow impeding device in the parent vessel, are not without drawbacks. Such an approach may impede blood flow into peripheral blood vessels while blocking the aneurysm neck in the parent vessel. Impeding flow to the peripheral blood vessel can unintentionally lead to severe damage if the openings of the vessels are blocked.
- Alternatives to embolic coils are being explored, such as tubular braided implants. Tubular braided implants have the potential to easily, accurately, and safely treat an aneurysm or other arterio-venous malformation in a parent vessel without blocking flow into perforator vessels communicating with the parent vessel. Compared to embolic coils, however, tubular braided implants are a newer technology, and there is therefore capacity for improved geometries, configurations, delivery systems, etc. for the tubular braided implants. For instance, delivery of tubular braided implants can require unique delivery systems to prevent the braid from inverting or abrading when pushed through a microcatheter, and some simple delivery systems that push embolic coils through microcatheters from their proximal end may not be effective to deliver tubular braids.
- There is therefore a need for improved methods, devices, and systems for implants for aneurysm treatment.
- It is an object of the present invention to provide systems, devices, and methods to meet the above-stated needs. Generally, it is an object of the present invention to provide a braided implant with a retractable dual proximal layer. The implant can secure within an aneurysm sac and occlude at least a majority of the aneurysm's neck. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can also have a retractable ball segment at the proximal end of the device made of the same braid that can be heat treated into an ellipsoid shape. The retractable ball segment can be movable from a position outside the aneurysm to a position at least partially enclosed within the implant to increase or decrease the height of the implant relative to the aneurysm or better conform the implant to the neck of the aneurysm.
- In some examples presented herein, the dual layer can be shaped by expanding it radially, and the dual layer can be pressed distally into a first portion of the tubular braid already within the aneurysm. By pressing the dual layer distally into the first portion of the tubular braid, the first portion of the tubular braid can be moved towards the distal portion of an aneurysm wall so that the implant can partially or completely occlude an aneurysm neck. Pushing the dual layer into the first portion of the braid can help conform the implant to the shape of the aneurysm and resist compaction. The dual layer when expanded radially and pressed into the first portion of the braid also can provide additional coverage at the neck of the aneurysm to increase thrombosis. In some examples, the dual layer can also be placed within the aneurysm sac with only a detachment point external to the sac.
- In some examples, the tubular braid can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted.
- In some examples the tubular braid can be shaped to a delivery shape that is extended to a single layer of tubular braid having a compressed circumference/diameter sized to be delivered through the microcatheter.
- In some examples, before the implant is released from the delivery system, the implant can be partially or fully retracted into the microcatheter and repositioned.
- An example method for forming an occlusive device to treat an aneurysm can include one or more of the following steps presented in no particular order, and the method can include additional steps not included here. An implant with a tubular braid, an open end, and a pinched end can be selected. The tubular braid can be shaped to a predetermined shape. Shaping the tubular braid to a predetermined shape can also include further steps. These steps can include inverting the tubular braid to form a distal inversion. The tubular braid can also be inverted to form a proximal inversion by moving the open end over at least a portion of the braid. A first segment of the tubular braid extending between the open end and the proximal inversion can be shaped. A second segment of the tubular braid extending between the proximal inversion and the distal inversion can be shaped. The open end can be positioned to encircle the second segment. A third segment extending from the distal inversion to the proximal inversion can be shaped. The second segment can be positioned to surround the third segment. A fourth segment of the tubular braid extending from the third segment radially outward from a central axis to cross the proximal inversion can be shaped and can fold and converge at the pinched end. The fourth segment can be positioned near the neck of an aneurysm.
- An example method for treating an aneurysm can include one or more of the following steps presented in no particular order, and the method can include additional steps not included here. A first portion of a tubular braided implant, which can have a tubular braid, an open end, and a pinched end, can be positioned within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac. The first portion can have one or more inversions. A second portion of the tubular braided implant can be expanded radially to occlude a majority of a neck of the aneurysm. The second portion can be pressed distally into the first portion. The first portion of the tubular braided implant can be moved toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- In some examples, expanding the second portion of the tubular braided implant can include positioning a fold in the second segment to define a substantially circular perimeter of the second portion and compressing the second portion along a central axis of the tubular braided implant such that the second portion can have a substantially circular shape having an area and two layers of braid over a majority of the area of the substantially circular shape.
- In some examples, positioning the first portion of the tubular braided implant can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion. In another example, positioning the first portion of the tubular braided implant can further involve positioning a proximal inversion near the neck of the aneurysm and positioning a distal inversion approximate the distal portion of the aneurysm wall. In another example, positioning the first portion of the tubular braided implant can further involve positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose at least a portion of a wall of the aneurysm within the aneurysm's sac, and shaping a second segment of the tubular braid such that the first segment provides an outwardly radial force in a plane defining a boundary between the aneurysm and blood vessel branches, the force sufficient to appose the first segment to walls of the aneurysm.
- In some examples, pressing the second portion distally into the first portion can further involve pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant.
- Another example implant can be formed in a series of steps and heat treated to be set to a predetermined shape. The tubular braid can include two inversions, a pinched end, and an open end. The tubular braid can also include four segments. The first segment can extend from the open end of the tubular braid to a proximal inversion. The second segment can be at least partially encircled by the open end and can extend from the proximal inversion to a distal inversion.
- The third segment can then be surrounded by the second segment and extend from the distal inversion to a ball segment. The ball segment can extend from a proximal end of the third segment and be shaped radially outward from a central axis of the tubular braid to form a substantially ellipsoid shape and converge at the pinched end. This form can be heat treated with a mold to set the implant into the predetermined shape, and once the mold is removed, the predetermined shape is formed.
- This example implant can then be implanted within an aneurysm. The aneurysm can have a range of different heights. When in the implanted shape, the braid can have an outer layer corresponding to the first segment of the predetermined shape and positioned to contact an aneurysm wall. The braid can also have a proximal inversion corresponding to the proximal inversion of the predetermined shape positioned near an aneurysm neck, and a sack corresponding to the second segment of the predetermined shape that apposes the outer layer. A distal inversion can correspond to the distal inversion of the predetermined shape, and a third segment can correspond to the third segment in the predetermined shape. The first, second, and third segments can make up a first portion of the braid. The braid can also have a ball segment corresponding to the ball segment of the predetermined shape and extending from the third segment radially outward from a central axis to form a substantially ellipsoid shape and converge at the pinched end. The ball segment can be pressed distally into the first portion of the tubular braid.
- When implanted, the ball segment can be positioned external to the aneurysm sac, extending across the aneurysm neck. The ball segment can occlude at least a portion of the aneurysm neck. By pressing the ball segment into the first portion of the tubular braid, the first portion of the tubular braid can be moved towards the distal portion of an aneurysm wall. Pushing the ball segment into the first portion of the braid can appose the proximal inversion to provide a radially outward force against the proximal inversion so that the tubular braid contacts a wall of the aneurysm approximate a neck of the aneurysm.
- In an alternative example, pushing the ball segment distally into the first portion of the tubular braid can push the third segment distally into the aneurysm towards a distal portion of the aneurysm wall. This movement of the third segment can be independent of distal movement of the outer layer and/or sack. This can extend the height of the implant to better conform to the height of the aneurysm. At least a portion of the ball segment can be enclosed by the sack. At least a portion of the ball segment can be positioned external to the sack.
- An example method for treating an aneurysm can include positioning a first portion of a tubular braided implant, the tubular braided implant having a tubular braid, an open end, and a pinched end, to circumferentially appose the aneurysm's walls. The first portion can include one or more inversions, including a distal inversion approximate a distal portion of the aneurysm wall. This example method can further include expanding a second portion of the tubular braided implant in connection with the first portion of the tubular braided implant radially to occlude a majority of the neck of the aneurysm. Then, the second portion can be pressed distally into the first portion to provide a radial force against the first portion towards the aneurysm wall approximate the neck of the aneurysm in a plane defining a boundary between the aneurysm and blood vessel branches. Lastly, the distal inversion can be moved toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion.
- Another example method for forming an occlusive device to treat an aneurysm can include the step of inverting a tubular braid comprising an open end and a pinched end to form a distal inversion. The method can further involve inverting the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid. The method can also include shaping a first segment of the tubular braid extending between the open end and the proximal inversion. The example method can further include shaping a second segment of the tubular braid extending between the proximal inversion and the distal inversion. The method can also include positioning the open end to encircle the second segment. The method can further involve shaping a third segment extending from the distal inversion to the pinched end. Then, the method can include positioning the second segment to surround the third segment. The method can further include shaping a ball segment of the tubular braid extending from the third segment radially outward from a central axis to form a substantially ellipsoid and converge at the pinched end. The method can also involve applying a mold to the ball segment of the tubular braid and treating the ball segment with heat to conform the ball segment to a formed shape, the ball segment movable along a central axis of the tubular braid.
- The above and further aspects of this invention are further discussed with reference to the following description in conjunction with the accompanying drawings, in which like numerals indicate like structural elements and features in various figures. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating principles of the invention. The figures depict one or more implementations of the inventive devices, by way of example only, not by way of limitation.
-
FIG. 1A is an illustration of an example implant having a tubular braid in a predetermined shape according to aspects of the present invention; -
FIG. 1B is an illustration of the example implant with the tubular braid in a first implanted shape according to aspects of the present invention; -
FIGS. 2A through 2I are illustrations of an implant having a tubular braid that expands to an implanted shape similar to as illustrated inFIG. 1B as the tubular braid exits a microcatheter according to aspects of the present inventions; -
FIGS. 3A through 3B are flow diagrams for a method of forming an occlusive device to treat an aneurysm; -
FIGS. 4A through 4B are flow diagrams for a method for treating an aneurysm; -
FIGS. 5A through 5B are illustrations of an example implant being formed into a predetermined shape according to aspects of the present invention; -
FIGS. 6A through 6C are illustrations of an implant having a tubular braid in an implanted shape according to aspects of the present invention; -
FIG. 7 is a flow diagram for a method of treating an aneurysm; and -
FIG. 8 is a flow diagram for a method of forming an occlusive device to treat an aneurysm. - Examples presented herein generally include a braided implant that can secure within an aneurysm sac and occlude a majority of the aneurysm's neck. The implant can include a tubular braid that can be set into a predetermined shape, compressed for delivery through a microcatheter, and implanted in at least one implanted position that is based on the predetermined shape and the geometry of the aneurysm in which the braid is implanted. The implant can include a single layer of braid (e.g. a braid that can be extended to form a single layer tube) heat treated into multiple layers with retractable dual layer at the proximal end of the tubular braid. When compressed, the implant can be sufficiently short to mitigate friction forces produced when the implant is delivered unsheathed through the microcatheter.
- A first portion of the tubular braid can be positioned in an aneurysm, after which the retractable dual layer can be deployed from the microcatheter and pushed onto the first portion of the tubular braid. This configuration provides three layers of braid at the neck of the aneurysm. The dual layer can potentially cover any gap between the first portion of implanted tubular braid and the aneurysm neck, and can potentially increase metal coverage, decrease porosity of the implant, and increase stasis and blood flow diversion at the neck of the aneurysm to promote the sealing and healing of the aneurysm compared a similarly shaped braided implant lacking the dual layer. The entire implant can be retractable until a desired position is achieved.
-
FIGS. 1A and 1B are illustrations of anexample braided implant 100 that can have a predetermined shape as shown inFIG. 1A and a distinct implanted shape as illustrated inFIG. 1B . Theimplant 100 can treat a range of aneurysm sizes. Theimplant 100 can include atubular braid 110 having anopen end 114 and apinched end 112. Theimplant 100 can include a connection and detachment feature 150 (referred to equivalently as “connection feature” and “detachment feature” herein) attached to thebraid 110 at thepinched end 112. Thepinched end 112 can include a marker band and/or soldered point with visibility, and/or theconnection feature 150 can include radiopaque material. Thetubular braid 110 can be formed in the predetermined shape (FIG. 1A ), collapsed for delivery through a microcatheter, attached to a delivery system atconnection feature 150, and implanted in an implanted shape such as the one shown inFIG. 1B . - Referring to
FIG. 1A , when in the predetermined shape, thetubular braid 110 can include twoinversions pinched end 112, and anopen end 114. Thetubular braid 110 can include four segments, 142, 144, 146, and 152. Thefirst segment 142 can extend from theopen end 114 of thetubular braid 110 to aproximal inversion 122. Thesecond segment 144 can be encircled by theopen end 114 and extend from theproximal inversion 122 to adistal inversion 124. Thethird segment 146 can be surrounded by thesecond segment 144 and extend from thedistal inversion 124 to theproximal inversion 122. Thefirst segment 142,second segment 144, andthird segment 146 can form the first portion of thetubular braid 110. Thefourth segment 152 can extend from thethird segment 146 radially outward from a central axis to cross theproximal inversion 122, fold, and converge at thepinched end 112. Thefourth segment 152 can be partially encircled by theproximal inversion 122. - When in the predetermined shape, the
tubular braid 110 can be substantially radially symmetrical about a central vertical axis. Thedetachment feature 150 is illustrated inFIG. 1A as a flat key that can be used with a mechanical delivery implant system (not pictured). Thetubular braid 110 can be formed into the predetermined shape by first inverting the braid outwardly to separate thethird segment 146 from thesecond segment 144 with adistal inversion 124. Then, thesecond segment 144 can be shaped over a form to produce the substantially “S” shaped profile illustrated inFIG. 1A . Next, thebraid 110 can be inverted outwardly again to separate thesecond segment 144 from thefirst segment 142 with aproximal inversion 122. Finally, thefourth segment 152 can be shaped by expanding thefourth segment 152 radially. Thefourth segment 152 can be pressed distally into the first portion of thetubular braid 110. It can also be advantageous to minimize aneck opening 126 defined by the lower extension of the “S” shape ofsecond segment 144 to maximize occlusion of an aneurysm neck when theimplant 100 is implanted. - The
tubular braid 110 can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted. When thetubular braid 110 is in the predetermined shape as depicted inFIG. 1A , thefourth segment 152 can comprise a diameter D1 greater than or approximately equal to a maximum diameter D2 of thefirst segment 142. Alternatively, when thetubular braid 110 is in the predetermined shape as depicted inFIG. 1A , thefourth segment 152 can comprise a diameter D1 lesser than a maximum diameter D2 of thefirst segment 142. When thetubular braid 110 is in the predetermined shape (FIG. 1A ), thesecond segment 144 can form a sack, and at least a portion of thethird segment 146 can positioned within the sack and at least a portion of thefourth segment 152 can be positioned external to the sack. As illustrated (FIG. 1B ), when implanted, thefourth segment 152 can be positioned external to the aneurysm sac, extending across theaneurysm neck 16. Preferably, thefourth segment 152 can appose vasculature walls surrounding theaneurysm neck 16 when implanted. Alternatively, the shapedfourth segment 152 can also be placed within the aneurysm sac. Thedetachment feature 150 can be implanted centrally in theaneurysm neck 16. Thedetachment feature 150 can be positioned external to thesac 12. - The
tubular braid 110 in the implanted shape (FIG. 1B ) can be radially or vertically compressed or extended compared to the predetermined shape. As illustrated inFIG. 1B , when in the implanted shape, thebraid 110 can have anouter layer 142 a corresponding to thefirst segment 142 of the predetermined shape and positioned to contact ananeurysm wall 14 of theaneurysm 10, aproximal inversion 122 a corresponding to theproximal inversion 122 of the predetermined shape and positioned to be placed approximate aneck 16 of theaneurysm 10, and a sack 144 a corresponding to thesecond segment 144 of the predetermined shape and positioned to appose a portion of theaneurysm wall 14 of theaneurysm 10 and apposing theouter layer 142 a. Adistal inversion 124 a can correspond to thedistal inversion 124 of the predetermined shape, a third segment 146 a can correspond to thethird segment 146 in the predetermined shape. Thebraid 110 can also have a fourth segment 152 a corresponding to thefourth segment 152 of the predetermined shape and extending from the third segment 146 a radially outward from a central axis to cross theproximal inversion 122 a, fold, and converge at thepinched end 112. As described inFIG. 1A , the fourth segment 152 a can be pressed distally into the first portion of thetubular braid 110. - By pressing the fourth segment 152 a distally into the first portion of the
tubular braid 110, thefirst portion 142 a, 144 a, 146 a of thetubular braid 110 can be moved towards the distal portion of ananeurysm wall 15 to occlude a portion of theneck 16 of theaneurysm 10. Pushing the fourth segment 152 a into the first portion of thebraid 110 can help conform theimplant 100 to the shape of theaneurysm 10 and resist compaction. The fourth segment 152 a when expanded radially and pressed into the first portion of thebraid 110 also can provide additional coverage at theneck 16 of theaneurysm 10 to increase thrombosis and seal theaneurysm 10. When the fourth segment 152 a is pressed into the first portion of thebraid 110, three layers of braid are present at the neck of the aneurysm. The fourth segment 152 a can cover spatial gaps between the first portion of implantedtubular braid 110 and theaneurysm neck 16, and can potentially increase metal coverage, decrease porosity of theimplant 100, and increase stasis and blood flow diversion at theneck 16 of theaneurysm 10 to promote the sealing and thrombosis of theaneurysm 10. The fourth segment 152 a can be shaped to occlude the majority of ananeurysm neck 16 when thedevice 100 is implanted. The fourth segment 152 a can be shaped to completely occlude ananeurysm neck 16 when thedevice 100 is implanted. - When the
tubular braid 110 is in the implanted shape (FIG. 1B ), the fourth segment 152 a can comprise a diameter D1 greater than or approximately equal to a maximum diameter D2 of thefirst segment 142 a. Alternatively, when thetubular braid 110 is in the implanted shape (FIG. 1B ), the fourth segment 152 a can comprise a diameter D1 lesser than a maximum diameter D2 of thefirst segment 142 a. When thetubular braid 110 is in the implanted shape (FIG. 1B ), the second segment 144 a can form a sack, and at least a portion of the third segment 146 a can be positioned within the sack and at least a portion of the fourth segment 152 a can be positioned external to the sack. The shaped fourth segment 152 a can also be placed within theaneurysm sac 12 with only thedetachment point 150 external to thesac 12. -
FIGS. 2A through 2I are illustrations of anexample implant 100 having abraid 110 expanding to an implanted shape that is based on a predetermined shape and the anatomy of the aneurysm and nearby blood vessel as thebraid 110 exits amicrocatheter 600. Theimplant 100 has a predetermined shape similar to the shape illustrated inFIG. 1A . As illustrated inFIG. 2A , thebraid 110 can be shaped to a delivery shape that is extended to a single layer of tubular braid having a compressed circumference/diameter sized to be delivered through themicrocatheter 600 and a length L. As will be appreciated and understood by a person of ordinary skill in the art, the length L of aspecific braid 110 can be tailored based on the size and shape of the aneurysm being treated. The length L can be approximately 1 inch in length. - During delivery through the
microcatheter 600, thedetachment feature 150 can be attached to a delivery system at a proximal end of theimplant 100, thepinched end 112 can be positioned near the proximal end of theimplant 100, and theopen end 114 can define the distal end of theimplant 100. Collapsing thebraid 110 to a single layer tube can result in abraid 110 that has a sufficiently small diameter and a sufficiently short length L to mitigate effects of friction force on thebraid 110 when it is delivered through the microcatheter, allowing thebraid 110 to be delivered unsheathed in some applications - As illustrated in
FIG. 2B , theimplant 100 can be delivered to ananeurysm 10 through themicrocatheter 600. Theopen end 114 can be positioned to exit themicrocatheter 600 before any other portion of thebraid 110 exits the microcatheter. Theopen end 114 can expand within theaneurysm sac 12 as it exits themicrocatheter 600. The illustratedaneurysm 10 is positioned at a bifurcation including astem blood vessel 700 and twobranch vessels 702, and themicrocatheter 600 is illustrated being delivered through thestem blood vessel 700. It is contemplated that the implant could be delivered to an aneurysm on a sidewall of a blood vessel through a curved microcatheter, and such a procedure is intended to be embraced by the scope of the present disclosure. As illustrated inFIG. 2C , the distal portion of thebraid 110 can continue to expand radially within theaneurysm sac 12 as it exits themicrocatheter 600. As thebraid 110 is further pushed distally from themicrocatheter 600, thebraid 110 can appose theaneurysm wall 14 and conform approximate theaneurysm neck 16. Theaneurysm 10 being treated can have a diameter that is less than the outer diameter of thetubular braid 110 in the predetermined shape so that thebraid 110 tends to expand outwardly, providing a force against theaneurysm wall 14 and sealing approximate the perimeter of theaneurysm neck 16. - As illustrated in
FIG. 2D , thebraid 110 can form theproximal inversion 122 a defining thefirst segment 142 a as thebraid 110 is further pushed out of themicrocatheter 600. Theproximal inversion 122 a can be positioned approximate theaneurysm neck 16. Thedistal inversion 124 a defining the second segment 144 a can also begin to form as thebraid 110 is pushed out of themicrocatheter 600. As illustrated inFIGS. 2E through 2F , the “S” shape of the second segment 144 a can begin to form as thebraid 110 is further pushed from themicrocatheter 600. - As illustrated in
FIG. 2G , once the first portion of thebraid 110, which can comprise thefirst segment 142 a, second segment 144 a, and third segment 146 a, is in place within theaneurysm sac 12, the fourth segment 152 a can radially expand outside theaneurysm 10 as the distal portion of thebraid 110 continues to exit themicrocatheter 600. - As illustrated in
FIG. 2H , the fourth segment 152 a can then be compressed distally as it continues to radially expand, compressing the fourth segment 152 a up into the first portion of thebraid 110. - Finally, as illustrated in
FIG. 2I , the fourth segment 152 a can be compressed distally into the first portion of thebraid 110, at least partially occluding theneck 16 of theaneurysm 10 and theneck opening 126. Thepinched end 112 and/or thedetachment point 150 can remain external to the aneurysm sac once the fourth segment 152 a has reached its final expanded and compressed state. The fourth segment 152 a when compressed can be compressed to a minimal thickness as to not become an obstruction to the surrounding blood vessels. - Before the
implant 100 is released from the delivery system, theimplant 100 can be partially or fully retracted into themicrocatheter 600 and repositioned. -
FIG. 3A is a flow diagram for amethod 300 for forming an occlusive device to treat ananeurysm 10. Step 310 includes selecting an implant comprising a tubular braid, an open end, and a pinched end. Step 320 includes shaping the tubular braid to a predetermined shape, such as the one illustrated inFIG. 1A . As illustrated inFIG. 3B , step 320 can further comprise additional steps. Step 322 includes inverting the tubular braid to form a distal inversion. Step 324 inverts the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid. Step 326 includes shaping a first segment of the tubular braid extending between the open end and the proximal inversion. Step 328 shapes a second segment of the tubular braid extending between the proximal inversion and the distal inversion. Step 330 includes positioning the open end to encircle the second segment. Step 332 shapes a third segment extending from the distal inversion to the proximal inversion. Step 334 includes positioning the second segment to surround the third segment. Step 336 shapes a fourth segment of the tubular braid extending from the third segment radially outward from a central axis to cross the proximal inversion, fold inwardly toward the central axis, and converge at the pinched end. Step 338 includes positioning the fourth segment approximate a neck of an aneurysm. - In
method 300, step 320 of shaping the tubular braid to the predetermined shape can further include shaping the fourth segment to comprise a diameter greater than or approximately equal to a maximum diameter of the first segment. Inmethod 300, thestep 320 of shaping the tubular braid to the predetermined shape can further include shaping the fourth segment to a diameter lesser than a maximum diameter of the first segment. Themethod 300 can further include shaping the tubular braided implant to a delivery shape sized to traverse a lumen of a microcatheter. -
FIG. 4A is a flow diagram for amethod 400 for a method for treating ananeurysm 10. Step 410 positions a first portion of a tubular braided implant, the tubular braided implant comprising a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac. The first portion can include one or more inversions. Step 420 includes expanding a second portion of the tubular braided implant radially to occlude a majority of a neck of the aneurysm. Step 430 presses the second portion distally into the first portion. Pressing the second portion distally into the first portion can create three layers of braid at the neck of the aneurysm. The second portion can cover any spatial gaps between the first portion and the aneurysm neck, and can potentially increase metal coverage, decrease porosity of the implant, and increase stasis and blood flow diversion at the neck of the aneurysm to promote the sealing and healing of the aneurysm. Step 440 includes moving the first portion of the tubular braided implant toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion. - As illustrated in
FIG. 4B , step 420 can further include step 422, which includes positioning a fold in the second segment to define a substantially circular perimeter of the second portion. Step 420 can additionally, or alternatively includestep 424, which includes compressing the second portion along a central axis of the tubular braided implant such that the second portion comprises a substantially circular shape having an area and the second portion comprises two layers of braid over a majority of the area of the substantially circular shape. - Step 410 can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion. Step 410 can further include positioning a proximal inversion in the first portion of the tubular braided implant approximate the neck of an aneurysm and positioning a distal inversion in the first portion of the tubular braided implant approximate the distal portion of the aneurysm wall. Step 410 can further include positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose an at least a portion of a wall of the aneurysm within the aneurysm's sac, and shaping a second segment of the tubular braid such that the first segment provides an outwardly radial force in a plane defining a boundary between the aneurysm and blood vessel branches, the force sufficient to appose the first segment to walls of the aneurysm.
- Step 430 can further include pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant. Step 440 can further include moving the distal inversion in the first portion of the tubular braided implant toward the distal portion of the aneurysm wall.
- The
method 400 can further include shaping the tubular braided implant to form a columnar post encircling a central axis of the tubular braided implant and extending a majority of a height of the first portion. Themethod 400 can further include retracting the tubular braid until a desired position is achieved relative to the aneurysm. Themethod 400 can further comprise shaping the tubular braided implant to a delivery shape sized to traverse a lumen of a microcatheter. -
FIGS. 5A through 5B are illustrations of anexample braided implant 200 as it is formed into a predetermined shape (FIG. 5B ). Theimplant 200 can treat a range of aneurysm sizes. Theimplant 200 can include atubular braid 210 having anopen end 214 and apinched end 212, similar toFIGS. 1A and 1B . Thetubular braid 210 can include memory shape material that can be heat set to a predetermined shape, can be deformed for delivery through a catheter, and can self-expand to an implanted shape that is based on the predetermined shape and confined by the anatomy of the aneurysm in which it is implanted. - When in the predetermined shape, the
tubular braid 210 can be substantially radially symmetrical about a central vertical axis. Theimplant 200 can include a connection and detachment feature 150 as illustrated in prior figures. Thepinched end 212 can include a marker band and/or soldered point with visibility, and/or theconnection feature 150 can include radiopaque material. Thetubular braid 210 can be formed in the predetermined shape (FIG. 5B ), collapsed to a delivery shape with a single layer ofbraid 210 for delivery through a microcatheter similar toFIG. 2A , attached to a delivery system atconnection feature 150, and implanted in an implanted shape such as the ones shown inFIGS. 6A-6C in a manner similar to the delivery described inFIGS. 2A through 2F . - Referring to
FIG. 5A , thetubular braid 210 can include two inversions, 222, 224, a pinched end, 212, and anopen end 214. Thetubular braid 210 as depicted inFIG. 5A can include four segments, 242, 244, 246, and 248. Thefirst segment 242 can extend from theopen end 214 of thetubular braid 210 to aproximal inversion 222. Thesecond segment 244 can be encircled by theopen end 214 and can extend from theproximal inversion 222 to adistal inversion 224. Thethird segment 246 can be surrounded by thesecond segment 244. - The tubular braid can be formed into a predetermined shape by first inverting the
braid 210 outwardly to separate thethird segment 246 from thesecond segment 244 with adistal inversion 224. Then, thesecond segment 244 can be shaped over a form or mold. The form can be in the shape of a sack. Next, thebraid 210 can be inverted outwardly again to separate thesecond segment 244 from thefirst segment 242 with aproximal inversion 222. - As further illustrated in
FIG. 5A , thethird segment 246 can span from thedistal inversion 224 to theball segment 248. Thefirst segment 242,second segment 244, andthird segment 246 can form a first portion of thetubular braid 210. Theball segment 248 can extend from a proximal portion of thethird segment 246 radially outward from a central axis of thetubular braid 210 to form a substantially ellipsoid shape and converge at thepinched end 212. Amold 220 can be applied, and this form wherein theball segment 248 is shaped can be treated with heat in order to set the predetermined shape as depicted inFIG. 5B . - As seen in
FIG. 5B , theball segment 248 can be pressed distally into the first portion of thetubular braid 210. When theball segment 248 is pressed distally into the first portion of thetubular braid 210, theball segment 248 can provide a radially outward force to appose theproximal inversion 222. Further, when theball segment 248 is pressed distally into the first portion of thetubular braid 210, theball segment 248 can be at least partially enclosed within thesecond segment 244 distal to theproximal inversion 222. Theball segment 248 can also be fully enclosed within thesecond segment 244 distal to theproximal inversion 222. When thetubular braid 210 is in the predetermined shape, thesecond segment 244 can form a sack, and at least a portion of thethird segment 246 can positioned within the sack and at least a portion of theball segment 248 can be positioned external to the sack. Theball segment 248 can occlude at least a portion of theproximal inversion 222 to seal the opening created by theproximal inversion 222. -
FIGS. 6A through 6C are illustrations of anexample braided implant 200 implanted within ananeurysm 10. Thetubular braid 210 can be radially or vertically compressed or extended compared to the predetermined shape to conform to aneurysms of varying sizes, heights, and shapes. As illustrated inFIG. 6A , when in the implanted shape in ananeurysm 10 with a height H1, thebraid 210 can have an outer layer 242 a corresponding to thefirst segment 242 of the predetermined shape and positioned to contact ananeurysm wall 14 of theaneurysm 10, a proximal inversion 222 a corresponding to theproximal inversion 222 of the predetermined shape and positioned to be placed approximate aneck 16 of theaneurysm 10, and a sack 244 a corresponding to thesecond segment 244 of the predetermined shape and positioned to appose the outer layer 242 a. Adistal inversion 224 a can correspond to thedistal inversion 224 of the predetermined shape, and a third segment 246 a can correspond to thethird segment 246 in the predetermined shape. Thebraid 210 can also have aball segment 248 a corresponding to theball segment 248 of the predetermined shape and extending from the third segment 246 a radially outward from a central axis to form a substantially ellipsoid shape and converge at thepinched end 212. As described inFIG. 5B , theball segment 248 a can be pressed distally into the first portion of thetubular braid 210. Pressing theball segment 248 a distally into the first portion of thetubular braid 210 can result in multiple layers ofbraid 210 seated at theneck 16 of theaneurysm 10. These multiple layers ofbraid 210 can inhibit blood flow into theaneurysm 10 by better occluding theaneurysm neck 16, by better occluding the channel formed by the proximal inversion 222 a, or both. - As illustrated in
FIG. 6A , when implanted, theball segment 248 a can be positioned external to theaneurysm 10, extending across theaneurysm neck 16. Theball segment 248 a can occlude at least a portion of theaneurysm neck 16. Theball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a. -
FIG. 6B depicts animplant 200 in ananeurysm 10 with a height H2. The height H2 of the aneurysm inFIG. 6B can be greater than the height H1 of the aneurysm inFIG. 6A . By pressing theball segment 248 a into the first portion of thetubular braid 210 within an aneurysm with a height H2, the first portion 242 a, 244 a, 246 a of thetubular braid 210 can be moved further into theaneurysm 10 towards the distal portion of ananeurysm wall 15. Theball segment 248 a can occlude at least a portion of theneck 16 of theaneurysm 10. Theball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a. Pushing theball segment 248 a into the first portion of thebraid 210 can also appose theproximal inversion 222 to provide a radially outward force against theproximal inversion 222 so that thetubular braid 210 apposes awall 14 of theaneurysm 10 approximate aneck 16 of theaneurysm 10. - Alternatively, pushing the
ball segment 248 a distally into the first portion of thetubular braid 210 can push the third segment 246 a distally into the aneurysm towards a distal portion of theaneurysm wall 15, independent of distal movement of the outer layer 242 a and/or sack 244 a. This can extend the height of theimplant 200 to better conform to the height of the aneurysm H2. At least a portion of theball segment 248 a can be enclosed by the sack 244 a. At least a portion of theball segment 248 a can be positioned external to the sack 244 a. - As illustrated in
FIG. 6C , theimplant 200 can be deployed within an aneurysm with a height H3 greater than H1 and H2 inFIGS. 6A and 6B respectively. As seen here, theball segment 248 a can be pushed distally even further into the first portion of thetubular braid 210 until it is completely enclosed within the sack 244 a. By pressing theball segment 248 a into the first portion of thetubular braid 210 within an aneurysm with a height H3, the first portion 242 a, 244 a, 246 a of thetubular braid 210 can be moved towards the distal portion of ananeurysm wall 15. Alternatively, as described inFIG. 6B , pushing theball segment 248 a distally into the first portion of thetubular braid 210 can push the third segment 246 a distally into the aneurysm towards a distal portion of theaneurysm wall 15, independent of distal movement of the outer layer 242 a and/or sack 244 a. This can extend the height of theimplant 200 to better conform to the height of the aneurysm H3. Theball segment 248 a can occlude at least a portion of theaneurysm neck 16. Theball segment 248 a can also occlude at least a portion of the proximal inversion 222 a to seal the opening created by the proximal inversion 222 a. In this way, theimplant 200 can be used to treat implants of varying heights and widths depending on the positioning of theball segment 248 relative to the first portion of thebraid 210. -
FIG. 7 is a flow diagram for amethod 700 for treating ananeurysm 10. Themethod 700 can be utilized to treat aneurysms of varying sizes, heights, and shapes with a single device. Step 710 positions a first portion of a tubular braided implant, the tubular braided implant having a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first portion circumferentially apposes walls within the sac. The first portion can include one or more inversions, including a distal inversion approximate a distal portion of the aneurysm wall. Step 720 includes expanding a second portion of the tubular braided implant in connection with the first portion of the tubular braided implant radially to occlude a majority of the neck of the aneurysm. Step 730 presses the second portion distally into the first portion to provide a radial force against the first portion towards the aneurysm wall approximate the neck of the aneurysm in a plane defining a boundary between the aneurysm and blood vessel branches. Lastly, Step 740 moves the distal inversion toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion. - The
step 710 of positioning the first portion of the tubular braided implant can further include positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall, positioning a proximal inversion in the first portion of the tubular braided implant approximate the neck of an aneurysm; and shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose an at least a portion of a wall of the aneurysm within the aneurysm's sac. - The step 720 of expanding the second portion of the tubular braided implant can further include compressing the second portion along a central axis of the tubular braided implant such that the second portion forms a substantially ellipsoidal shape.
- The
step 730 of pressing the second portion distally into the first portion can further include apposing at least a part of the first portion with the second portion to provide an outwardly radial force along a central axis of the tubular braided implant from the second portion to the first portion. Thestep 730 of pressing the second portion distally can also involve pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant until the second portion of the tubular braided implant is at least partially enclosed by the proximal inversion. Thestep 730 of pressing the second portion distally can also disrupt the flow of blood into the aneurysm by placing multiple layers of braid approximate the neck of the aneurysm. - The
method 700 can further include shaping the tubular braided implant to a delivery shape with a single layer of braid sized to traverse a lumen of a microcatheter. -
FIG. 8 is a flow diagram for a method of forming an occlusive device to treat an aneurysm. The method can include inverting a tubular braid comprising an open end and a pinched end to form a distal inversion (810); inverting the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid (820); shaping a first segment of the tubular braid extending between the open end and the proximal inversion (830); shaping a second segment of the tubular braid extending between the proximal inversion and the distal inversion (840); positioning the open end to encircle the second segment (850); shaping a third segment extending from the distal inversion to the pinched end (860); positioning the second segment to surround the third segment (870); shaping a ball segment of the tubular braid extending from the third segment radially outward from a central axis to form a substantially ellipsoid shape and converge at the pinched end (880); and applying a mold to the ball segment of the tubular braid and treating the ball segment with heat to conform the ball segment to the formed shape, the ball segment movable along a central axis of the tubular braid (890). - The
method 800 can further include positioning the first segment, second segment, and third segment within an aneurysm, and advancing the ball segment distally into the proximal inversion. This step of advancing the ball segment distally into the proximal inversion can move the distal inversion towards a distal portion of a wall of the aneurysm, which can conform the device to the height of the aneurysm. In this manner, the device can be used to treat aneurysms of varying heights, shapes, and sizes. - The
method 800 can also include apposing the proximal inversion with at least a portion of the ball segment. Themethod 800 can further include moving the ball segment to a position at least partially enclosed by the second segment distal to the proximal inversion. Themethod 800 can also involve retracting the tubular braid until a desired position is achieved relative to the aneurysm. - As used herein, the terms “about” or “approximately” for any numerical values or ranges indicate a suitable dimensional tolerance that allows the part or collection of components to function for its intended purpose as described herein.
- The descriptions contained herein are examples of embodiments of the invention and are not intended in any way to limit the scope of the invention. The invention contemplates many variations and modifications of the implant, including: alternative delivery methods, alternative braid materials, alternative means for achieving a desired stiffness/flexibility of braid material, additional structures affixed to the implant (e.g. to aid in anchoring the implant, blood flow diversion, embolism formation, etc.), alternative predetermined braid shapes (e.g. one inversion, three inversions, four inversions, five or more inversions, non-radially symmetric shapes, alternative segment shapes, etc.), alternative implanted shapes, etc. The invention contemplates many variations and modifications to constructing the implant to include combinations of the aforementioned variations and modifications of the implant. The invention contemplates many variations and modifications of implanting the implant to accommodate combinations of the aforementioned variations and modifications of the implant. Modifications apparent to one of ordinary skill in the art following the teachings of this disclosure are intended to be within the scope of the claims which follow.
Claims (20)
1. A method for treating an aneurysm, the method comprising:
positioning a first portion of a tubular braided implant, the tubular braided implant comprising a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first portion circumferentially apposes walls within the aneurysm sac, extends from the open end of the tubular braid, and comprises one or more inversions, including a distal inversion positioned approximate a distal portion of the aneurysm wall;
expanding a second portion of the tubular braided implant in connection with the first portion of the tubular braided implant radially to occlude a majority of a neck of the aneurysm;
pressing the second portion distally into the first portion to provide a radial force against the first portion towards the aneurysm wall approximate a neck of the aneurysm; and
moving the distal inversion toward a distal portion of the aneurysm wall as a result of pressing the second portion distally into the first portion,
wherein the second portion is pressed distally into the first portion in a plane defining a boundary between the aneurysm and a blood vessel branch.
2. The method of claim 1 , wherein expanding the second portion of the tubular braided implant further comprises:
compressing the second portion along a central axis of the tubular braided implant such that the second portion forms a substantially ellipsoidal shape.
3. The method of claim 1 , further comprising shaping the tubular braided implant to a delivery shape comprising a single layer of braid and sized to traverse a lumen of a microcatheter.
4. The method of claim 1 , wherein pressing the second portion distally into the first portion further comprises apposing at least a part of the first portion with the second portion to provide an outwardly radial force along a central axis of the tubular braided implant from the second portion to the first portion.
5. The method of claim 1 , wherein pressing the second portion distally into the first portion disrupts the flow of blood into the aneurysm by placing multiple layers of braid approximate the neck of the aneurysm.
6. The method of claim 1 , wherein positioning the first portion of the tubular braided implant further comprises:
positioning the open end of the tubular braided implant to circumferentially appose the aneurysm wall;
positioning a proximal inversion in the first portion of the tubular braided implant approximate the neck of an aneurysm; and
shaping a first segment of the tubular braid extending between the open end and the proximal inversion to appose an at least a portion of the wall of the aneurysm within the aneurysm's sac.
7. The method of claim 6 ,
wherein pressing the second portion distally into the first portion further comprises pressing the second portion of the tubular braided implant against the proximal inversion in the first portion of the tubular braided implant until the second portion of the tubular braided implant is at least partially enclosed by the proximal inversion, providing an outwardly radial force in a plane defining a boundary between the aneurysm and blood vessel branches.
8. The method of claim 1 ,
wherein pressing the second portion distally into the first portion further comprises enclosing the second portion of the tubular braided implant within the first portion of the tubular braided implant.
9. A method for treating an aneurysm, the method comprising:
positioning a first segment of a tubular braided implant, the tubular braided implant comprising a tubular braid, an open end, and a pinched end, within a sac of the aneurysm such that the first segment extends from the open end of the tubular braid to a proximal inversion;
positioning a second segment of the tubular braided implant within the aneurysm sac, the second segment encircled by the open end and extending from the proximal inversion to a distal inversion; and
positioning a third segment of the tubular braided implant within the aneurysm sac, the third segment surrounded by the second segment and extending from the distal inversion, and
advancing a ball segment depending from the third segment distally into the proximal inversion, the ball segment extending radially outward from a central axis, providing a radially outward force, and converging at the pinched end to appose the proximal inversion.
10. The method of claim 9 , wherein the ball segment is enclosed by the second segment distal to the proximal inversion.
11. The method of claim 9 , wherein when the tubular braided implant is implanted in the aneurysm, the ball segment occludes at least a portion of an aneurysm neck.
12. The method of claim 9 , wherein the radially outward force is exerted against the proximal inversion so that the tubular braided implant contacts a wall of the aneurysm approximate a neck of the aneurysm.
13. The method of claim 9 , wherein when the tubular braided implant is implanted in the aneurysm, the second segment forms a sack, at least a portion of the third segment is positioned within the sack, and at least a portion of the ball segment is positioned external to the sack.
14. The method of claim 9 , wherein when the tubular braided implant is implanted in the aneurysm,
the first segment forms an outer layer positioned to contact an aneurysm wall of the aneurysm,
the proximal inversion is positioned to be placed approximate an aneurysm neck of the aneurysm, and
the second segment forms a sack positioned to appose a portion of the aneurysm wall of the aneurysm and to appose the outer layer.
15. A method for forming an occlusive device to treat an aneurysm comprising:
inverting a tubular braid comprising an open end and a pinched end to form a distal inversion;
inverting the tubular braid to form a proximal inversion by moving the open end over at least a portion of the braid;
shaping a first segment of the tubular braid extending between the open end and the proximal inversion;
shaping a second segment of the tubular braid extending between the proximal inversion and the distal inversion;
positioning the open end to encircle the second segment;
shaping a third segment extending from the distal inversion to the pinched end;
positioning the second segment to surround the third segment;
shaping a ball segment of the tubular braid extending from the third segment radially outward from a central axis to form a substantially ellipsoid shape and converge at the pinched end; and
applying a mold to the ball segment of the tubular braid and treating the ball segment with heat to conform the ball segment to the formed shape, the ball segment movable along a central axis of the tubular braid.
16. The method of claim 15 further comprising:
positioning the first segment, second segment, and third segment within an aneurysm, and
advancing the ball segment distally into the proximal inversion.
17. The method of claim 16 , whereby advancing the ball segment distally into the proximal inversion moves the distal inversion towards a distal portion of a wall of the aneurysm to conform the device to the height of the aneurysm.
18. The claim of method 16, further comprising moving the ball segment to a position at least partially enclosed by the second segment distal to the proximal inversion.
19. The method of claim 16 , wherein when the tubular braided implant is implanted in the aneurysm, the ball segment occludes at least a portion of an aneurysm neck.
20. The method of claim 16 , wherein the ball segment provides a radially outward force, the radially outward force being exerted against the proximal inversion so that the tubular braided implant contacts a wall of the aneurysm approximate a neck of the aneurysm.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18/101,630 US20230172614A1 (en) | 2019-05-21 | 2023-01-26 | Aneurysm treatment with pushable ball segment |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/418,199 US10653425B1 (en) | 2019-05-21 | 2019-05-21 | Layered braided aneurysm treatment device |
US16/748,877 US11413046B2 (en) | 2019-05-21 | 2020-01-22 | Layered braided aneurysm treatment device |
US16/853,135 US11497504B2 (en) | 2019-05-21 | 2020-04-20 | Aneurysm treatment with pushable implanted braid |
US16/865,165 US11672542B2 (en) | 2019-05-21 | 2020-05-01 | Aneurysm treatment with pushable ball segment |
US18/101,630 US20230172614A1 (en) | 2019-05-21 | 2023-01-26 | Aneurysm treatment with pushable ball segment |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/865,165 Division US11672542B2 (en) | 2019-05-21 | 2020-05-01 | Aneurysm treatment with pushable ball segment |
Publications (1)
Publication Number | Publication Date |
---|---|
US20230172614A1 true US20230172614A1 (en) | 2023-06-08 |
Family
ID=73457694
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/865,165 Active 2039-06-24 US11672542B2 (en) | 2019-05-21 | 2020-05-01 | Aneurysm treatment with pushable ball segment |
US18/101,630 Pending US20230172614A1 (en) | 2019-05-21 | 2023-01-26 | Aneurysm treatment with pushable ball segment |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/865,165 Active 2039-06-24 US11672542B2 (en) | 2019-05-21 | 2020-05-01 | Aneurysm treatment with pushable ball segment |
Country Status (1)
Country | Link |
---|---|
US (2) | US11672542B2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11357511B2 (en) | 2008-05-01 | 2022-06-14 | Aneuclose Llc | Intrasacular aneurysm occlusion device with globular first configuration and bowl-shaped second configuration |
US11471164B2 (en) | 2008-05-01 | 2022-10-18 | Aneuclose Llc | Methods of occluding a cerebral aneurysm by inserting embolic members or material into an intrasacular implant |
US11583289B2 (en) | 2008-05-01 | 2023-02-21 | Aneuclose Llc | Aneurysm-occluding mesh ribbon with a series of loops or segments having distal-to-proximal variation in size, shape, and/or orientation |
US20230016312A1 (en) * | 2020-04-20 | 2023-01-19 | DePuy Synthes Products, Inc. | Aneurysm treatment with pushable implanted braid |
Family Cites Families (406)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2849002A (en) | 1956-03-12 | 1958-08-26 | Vincent J Oddo | Haemostatic catheter |
US3480017A (en) | 1966-04-27 | 1969-11-25 | Wallace B Shute | Cervical dilator |
US4085757A (en) | 1976-04-29 | 1978-04-25 | P Pevsner | Miniature balloon catheter method and apparatus |
US4282875A (en) | 1979-01-24 | 1981-08-11 | Serbinenko Fedor A | Occlusive device |
US4395806A (en) | 1980-05-08 | 1983-08-02 | Sorenson Research Co., Inc. | Method of manufacturing a detachable balloon catheter assembly |
US4364392A (en) | 1980-12-04 | 1982-12-21 | Wisconsin Alumni Research Foundation | Detachable balloon catheter |
US4545367A (en) | 1982-07-16 | 1985-10-08 | Cordis Corporation | Detachable balloon catheter and method of use |
US4517979A (en) | 1983-07-14 | 1985-05-21 | Cordis Corporation | Detachable balloon catheter |
WO1988003817A1 (en) | 1986-11-29 | 1988-06-02 | Terumo Kabushiki Kaisha | Catheter equipped with balloon |
US4836204A (en) | 1987-07-06 | 1989-06-06 | Landymore Roderick W | Method for effecting closure of a perforation in the septum of the heart |
US5067489A (en) | 1988-08-16 | 1991-11-26 | Flexmedics Corporation | Flexible guide with safety tip |
FR2641692A1 (en) | 1989-01-17 | 1990-07-20 | Nippon Zeon Co | Plug for closing an opening for a medical application, and device for the closure plug making use thereof |
US4991602A (en) | 1989-06-27 | 1991-02-12 | Flexmedics Corporation | Flexible guide wire with safety tip |
US5065772A (en) | 1989-10-13 | 1991-11-19 | Inamed Corporation | Inflatable cerivical pessary |
US5122136A (en) | 1990-03-13 | 1992-06-16 | The Regents Of The University Of California | Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas |
US6425893B1 (en) | 1990-03-13 | 2002-07-30 | The Regents Of The University Of California | Method and apparatus for fast electrolytic detachment of an implant |
JPH0546421Y2 (en) | 1990-08-23 | 1993-12-06 | ||
US5025060A (en) | 1990-10-15 | 1991-06-18 | Kansai Paint Co., Ltd. | Dispersion of fine particles of a polymer |
CA2380683C (en) | 1991-10-28 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Expandable stents and method for making same |
US5261916A (en) | 1991-12-12 | 1993-11-16 | Target Therapeutics | Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling |
ATE187053T1 (en) | 1991-12-12 | 1999-12-15 | Target Therapeutics Inc | UNCOUPLING, SLIDING, VESSEL-OCCLOSING SPIRAL WITH INTERLOCKING COUPLING ELEMENTS |
US5342387A (en) | 1992-06-18 | 1994-08-30 | American Biomed, Inc. | Artificial support for a blood vessel |
US5350397A (en) | 1992-11-13 | 1994-09-27 | Target Therapeutics, Inc. | Axially detachable embolic coil assembly |
US5334210A (en) | 1993-04-09 | 1994-08-02 | Cook Incorporated | Vascular occlusion assembly |
US5624449A (en) | 1993-11-03 | 1997-04-29 | Target Therapeutics | Electrolytically severable joint for endovascular embolic devices |
US5423829A (en) | 1993-11-03 | 1995-06-13 | Target Therapeutics, Inc. | Electrolytically severable joint for endovascular embolic devices |
JP2605559Y2 (en) | 1993-12-21 | 2000-07-24 | 株式会社パイオラックス | Treatment device for tubular organs |
US5846261A (en) | 1994-07-08 | 1998-12-08 | Aga Medical Corp. | Percutaneous catheter directed occlusion devices |
WO1996001591A1 (en) | 1994-07-08 | 1996-01-25 | Microvena Corporation | Method of forming medical devices; intravascular occlusion devices |
US5814062A (en) | 1994-12-22 | 1998-09-29 | Target Therapeutics, Inc. | Implant delivery assembly with expandable coupling/decoupling mechanism |
IL116561A0 (en) | 1994-12-30 | 1996-03-31 | Target Therapeutics Inc | Severable joint for detachable devices placed within the body |
US5634936A (en) | 1995-02-06 | 1997-06-03 | Scimed Life Systems, Inc. | Device for closing a septal defect |
US5645558A (en) | 1995-04-20 | 1997-07-08 | Medical University Of South Carolina | Anatomically shaped vasoocclusive device and method of making the same |
RU2157146C2 (en) | 1995-06-13 | 2000-10-10 | ВИЛЬЯМ КУК Европа, A/S | Device for performing implantation in blood vessels and hollow organs |
US6168622B1 (en) | 1996-01-24 | 2001-01-02 | Microvena Corporation | Method and apparatus for occluding aneurysms |
US5733294A (en) | 1996-02-28 | 1998-03-31 | B. Braun Medical, Inc. | Self expanding cardiovascular occlusion device, method of using and method of making the same |
US5853422A (en) | 1996-03-22 | 1998-12-29 | Scimed Life Systems, Inc. | Apparatus and method for closing a septal defect |
US6949116B2 (en) | 1996-05-08 | 2005-09-27 | Carag Ag | Device for plugging an opening such as in a wall of a hollow or tubular organ including biodegradable elements |
US5964797A (en) | 1996-08-30 | 1999-10-12 | Target Therapeutics, Inc. | Electrolytically deployable braided vaso-occlusion device |
US5941249A (en) | 1996-09-05 | 1999-08-24 | Maynard; Ronald S. | Distributed activator for a two-dimensional shape memory alloy |
US6254628B1 (en) | 1996-12-09 | 2001-07-03 | Micro Therapeutics, Inc. | Intracranial stent |
US6007573A (en) | 1996-09-18 | 1999-12-28 | Microtherapeutics, Inc. | Intracranial stent and method of use |
US5951599A (en) | 1997-07-09 | 1999-09-14 | Scimed Life Systems, Inc. | Occlusion system for endovascular treatment of an aneurysm |
US5928260A (en) | 1997-07-10 | 1999-07-27 | Scimed Life Systems, Inc. | Removable occlusion system for aneurysm neck |
DE69835958T2 (en) | 1997-08-04 | 2007-02-15 | Boston Scientific Ltd., Barbados | OCCLUSION SYSTEM FOR IMPROVING ANEURYSMAS |
US6063070A (en) | 1997-08-05 | 2000-05-16 | Target Therapeutics, Inc. | Detachable aneurysm neck bridge (II) |
GB9716497D0 (en) | 1997-08-05 | 1997-10-08 | Bridport Gundry Plc | Occlusion device |
JP4127960B2 (en) | 1997-08-05 | 2008-07-30 | ボストン サイエンティフィック リミテッド | Detachable aneurysm neck bridge |
US6086577A (en) | 1997-08-13 | 2000-07-11 | Scimed Life Systems, Inc. | Detachable aneurysm neck bridge (III) |
US5916235A (en) | 1997-08-13 | 1999-06-29 | The Regents Of The University Of California | Apparatus and method for the use of detachable coils in vascular aneurysms and body cavities |
US6146373A (en) | 1997-10-17 | 2000-11-14 | Micro Therapeutics, Inc. | Catheter system and method for injection of a liquid embolic composition and a solidification agent |
US6036720A (en) | 1997-12-15 | 2000-03-14 | Target Therapeutics, Inc. | Sheet metal aneurysm neck bridge |
ATE454098T1 (en) | 1998-02-10 | 2010-01-15 | Artemis Medical Inc | OCCLUSION, ANCHORING, CHIPING OR POWER CONTROL DEVICE |
US6379374B1 (en) | 1998-10-22 | 2002-04-30 | Cordis Neurovascular, Inc. | Small diameter embolic coil hydraulic deployment system |
US6063100A (en) | 1998-03-10 | 2000-05-16 | Cordis Corporation | Embolic coil deployment system with improved embolic coil |
US5925060A (en) | 1998-03-13 | 1999-07-20 | B. Braun Celsa | Covered self-expanding vascular occlusion device |
AU3454999A (en) | 1998-03-30 | 1999-10-18 | University Of Virginia Patent Foundation | Flow arrest, double balloon technique for occluding aneurysms or blood vessels |
US6168615B1 (en) | 1998-05-04 | 2001-01-02 | Micrus Corporation | Method and apparatus for occlusion and reinforcement of aneurysms |
SE514546C2 (en) | 1998-05-18 | 2001-03-12 | Allgon Ab | An antenna system and a radio communication device comprising an antenna system |
US6463317B1 (en) | 1998-05-19 | 2002-10-08 | Regents Of The University Of Minnesota | Device and method for the endovascular treatment of aneurysms |
US6113609A (en) | 1998-05-26 | 2000-09-05 | Scimed Life Systems, Inc. | Implantable tissue fastener and system for treating gastroesophageal reflux disease |
US5935148A (en) | 1998-06-24 | 1999-08-10 | Target Therapeutics, Inc. | Detachable, varying flexibility, aneurysm neck bridge |
US6096175A (en) | 1998-07-17 | 2000-08-01 | Micro Therapeutics, Inc. | Thin film stent |
WO2000013593A1 (en) | 1998-09-04 | 2000-03-16 | Boston Scientific Limited (Incorporated In Ireland) | Detachable aneurysm neck closure patch |
US7410482B2 (en) | 1998-09-04 | 2008-08-12 | Boston Scientific-Scimed, Inc. | Detachable aneurysm neck bridge |
WO2000021443A1 (en) | 1998-10-09 | 2000-04-20 | Cook Incorporated | Vasoocclusion coil device having a core therein |
US7128073B1 (en) | 1998-11-06 | 2006-10-31 | Ev3 Endovascular, Inc. | Method and device for left atrial appendage occlusion |
US7044134B2 (en) | 1999-11-08 | 2006-05-16 | Ev3 Sunnyvale, Inc | Method of implanting a device in the left atrial appendage |
US8016852B2 (en) | 1998-11-10 | 2011-09-13 | Stryker Corporation | Bioactive components for incorporation with vaso-occlusive members |
US6569179B2 (en) | 1998-11-10 | 2003-05-27 | Scimed Life Systems, Inc. | Bioactive three loop coil |
US6080183A (en) | 1998-11-24 | 2000-06-27 | Embol-X, Inc. | Sutureless vessel plug and methods of use |
EP3173035A1 (en) | 1999-02-01 | 2017-05-31 | Board of Regents, The University of Texas System | Woven intravascular devices |
US6428558B1 (en) | 1999-03-10 | 2002-08-06 | Cordis Corporation | Aneurysm embolization device |
US6375606B1 (en) | 1999-03-17 | 2002-04-23 | Stereotaxis, Inc. | Methods of and apparatus for treating vascular defects |
US6858034B1 (en) | 1999-05-20 | 2005-02-22 | Scimed Life Systems, Inc. | Stent delivery system for prevention of kinking, and method of loading and using same |
US6379329B1 (en) | 1999-06-02 | 2002-04-30 | Cordis Neurovascular, Inc. | Detachable balloon embolization device and method |
US6375668B1 (en) | 1999-06-02 | 2002-04-23 | Hanson S. Gifford | Devices and methods for treating vascular malformations |
US6551303B1 (en) | 1999-10-27 | 2003-04-22 | Atritech, Inc. | Barrier device for ostium of left atrial appendage |
US6689150B1 (en) | 1999-10-27 | 2004-02-10 | Atritech, Inc. | Filter apparatus for ostium of left atrial appendage |
US6994092B2 (en) | 1999-11-08 | 2006-02-07 | Ev3 Sunnyvale, Inc. | Device for containing embolic material in the LAA having a plurality of tissue retention structures |
US6331184B1 (en) | 1999-12-10 | 2001-12-18 | Scimed Life Systems, Inc. | Detachable covering for an implantable medical device |
US6350270B1 (en) | 2000-01-24 | 2002-02-26 | Scimed Life Systems, Inc. | Aneurysm liner |
US6346117B1 (en) | 2000-03-02 | 2002-02-12 | Prodesco, Inc. | Bag for use in the intravascular treatment of saccular aneurysms |
US6391037B1 (en) | 2000-03-02 | 2002-05-21 | Prodesco, Inc. | Bag for use in the intravascular treatment of saccular aneurysms |
US7153323B1 (en) | 2000-06-30 | 2006-12-26 | Boston Scientific Scimed, Inc. | Aneurysm liner with multi-segment extender |
US20020068974A1 (en) | 2000-07-21 | 2002-06-06 | Kuslich Stephen D. | Expandable porous mesh bag device and methods of use for reduction, filling, fixation and supporting of bone |
US6855154B2 (en) | 2000-08-11 | 2005-02-15 | University Of Louisville Research Foundation, Inc. | Endovascular aneurysm treatment device and method |
WO2002030487A2 (en) | 2000-10-11 | 2002-04-18 | Micro Thereapeutics, Inc. | Methods for treating aneurysms |
CA2431594A1 (en) | 2000-10-24 | 2002-09-12 | Martin Dieck | Device and methods for treating vascular malformations |
US6547804B2 (en) | 2000-12-27 | 2003-04-15 | Scimed Life Systems, Inc. | Selectively permeable highly distensible occlusion balloon |
US6866677B2 (en) | 2001-04-03 | 2005-03-15 | Medtronic Ave, Inc. | Temporary intraluminal filter guidewire and methods of use |
US20020147496A1 (en) | 2001-04-06 | 2002-10-10 | Integrated Vascular Systems, Inc. | Apparatus for treating spinal discs |
US20020188314A1 (en) | 2001-06-07 | 2002-12-12 | Microvena Corporation | Radiopaque distal embolic protection device |
US6454780B1 (en) | 2001-06-21 | 2002-09-24 | Scimed Life Systems, Inc. | Aneurysm neck obstruction device |
US20030181927A1 (en) | 2001-06-21 | 2003-09-25 | Wallace Michael P. | Aneurysm neck obstruction device |
US6572628B2 (en) | 2001-06-28 | 2003-06-03 | Cordis Neurovascular, Inc. | Method and apparatus for placing a medical agent into a vessel of the body |
US6964671B2 (en) | 2001-06-28 | 2005-11-15 | Cordis Neurovascular, Inc. | Method and apparatus for placing a medical agent into a vessel of the body |
US8715312B2 (en) | 2001-07-20 | 2014-05-06 | Microvention, Inc. | Aneurysm treatment device and method of use |
US7572288B2 (en) | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8252040B2 (en) | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
US20030028209A1 (en) | 2001-07-31 | 2003-02-06 | Clifford Teoh | Expandable body cavity liner device |
US6811560B2 (en) | 2001-09-20 | 2004-11-02 | Cordis Neurovascular, Inc. | Stent aneurysm embolization method and device |
US6802851B2 (en) | 2001-09-20 | 2004-10-12 | Gordia Neurovascular, Inc. | Stent aneurysm embolization method using collapsible member and embolic coils |
JP4350515B2 (en) | 2001-11-09 | 2009-10-21 | ルビコン・メデイカル・インコーポレイテツド | Stent delivery device |
JP2003190175A (en) | 2001-11-15 | 2003-07-08 | Cordis Neurovascular Inc | Aneurysm neck cover for sealing aneurysm |
JP4429589B2 (en) | 2001-11-15 | 2010-03-10 | コーディス・ニューロバスキュラー・インコーポレイテッド | Aneurysm embolization device using an occluding member |
US20060292206A1 (en) | 2001-11-26 | 2006-12-28 | Kim Steven W | Devices and methods for treatment of vascular aneurysms |
DE60315425T2 (en) | 2002-03-05 | 2008-06-26 | Salviac Ltd. | SYSTEM FOR PROTECTION FROM EMBOLICS |
US6773448B2 (en) | 2002-03-08 | 2004-08-10 | Ev3 Inc. | Distal protection devices having controllable wire motion |
US20030176884A1 (en) | 2002-03-12 | 2003-09-18 | Marwane Berrada | Everted filter device |
WO2003077776A1 (en) | 2002-03-15 | 2003-09-25 | Nmt Medical, Inc. | Coupling system useful in placement of implants |
US7695488B2 (en) | 2002-03-27 | 2010-04-13 | Boston Scientific Scimed, Inc. | Expandable body cavity liner device |
US20030195553A1 (en) | 2002-04-12 | 2003-10-16 | Scimed Life Systems, Inc. | System and method for retaining vaso-occlusive devices within an aneurysm |
US6833003B2 (en) | 2002-06-24 | 2004-12-21 | Cordis Neurovascular | Expandable stent and delivery system |
US20040034386A1 (en) | 2002-08-19 | 2004-02-19 | Michael Fulton | Aneurysm stent |
US8075585B2 (en) | 2002-08-29 | 2011-12-13 | Stryker Corporation | Device and method for treatment of a vascular defect |
US20040044391A1 (en) | 2002-08-29 | 2004-03-04 | Stephen Porter | Device for closure of a vascular defect and method of treating the same |
US7229454B2 (en) | 2003-01-07 | 2007-06-12 | Boston Scientific Scimed, Inc. | Occlusive cinching devices and methods of use |
US20040254594A1 (en) | 2003-01-24 | 2004-12-16 | Arthur Alfaro | Cardiac defect occlusion device |
US7744583B2 (en) | 2003-02-03 | 2010-06-29 | Boston Scientific Scimed | Systems and methods of de-endothelialization |
US7001369B2 (en) | 2003-03-27 | 2006-02-21 | Scimed Life Systems, Inc. | Medical device |
US7293562B2 (en) | 2003-03-27 | 2007-11-13 | Cierra, Inc. | Energy based devices and methods for treatment of anatomic tissue defects |
TWI221091B (en) | 2003-04-18 | 2004-09-21 | A Spine Holding Group Corp | Spine filling device |
US7597704B2 (en) | 2003-04-28 | 2009-10-06 | Atritech, Inc. | Left atrial appendage occlusion device with active expansion |
AU2004241111B2 (en) | 2003-05-15 | 2010-05-27 | Dsm Ip Assets B.V | Manufacture and use of implantable reticulated elastomeric matrices |
US7093527B2 (en) | 2003-06-10 | 2006-08-22 | Surpass Medical Ltd. | Method and apparatus for making intraluminal implants and construction particularly useful in such method and apparatus |
US7309345B2 (en) | 2003-07-25 | 2007-12-18 | Boston Scientific-Scimed, Inc. | Method and system for delivering an implant utilizing a lumen reducing member |
US7735493B2 (en) | 2003-08-15 | 2010-06-15 | Atritech, Inc. | System and method for delivering a left atrial appendage containment device |
DE10338702B9 (en) | 2003-08-22 | 2007-04-26 | Occlutech Gmbh | Occlusioninstrument |
US7371228B2 (en) | 2003-09-19 | 2008-05-13 | Medtronic Vascular, Inc. | Delivery of therapeutics to treat aneurysms |
US7232461B2 (en) | 2003-10-29 | 2007-06-19 | Cordis Neurovascular, Inc. | Neck covering device for an aneurysm |
AU2004289362A1 (en) | 2003-11-10 | 2005-05-26 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
US8231649B2 (en) | 2004-01-20 | 2012-07-31 | Boston Scientific Scimed, Inc. | Retrievable blood clot filter with retractable anchoring members |
JP2007519489A (en) | 2004-01-30 | 2007-07-19 | エヌエムティー メディカル, インコーポレイティッド | Welding system for closure of cardia |
US8777974B2 (en) | 2004-03-19 | 2014-07-15 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects |
US20050228434A1 (en) | 2004-03-19 | 2005-10-13 | Aga Medical Corporation | Multi-layer braided structures for occluding vascular defects |
US7678129B1 (en) | 2004-03-19 | 2010-03-16 | Advanced Cardiovascular Systems, Inc. | Locking component for an embolic filter assembly |
US9039724B2 (en) | 2004-03-19 | 2015-05-26 | Aga Medical Corporation | Device for occluding vascular defects |
BE1016067A3 (en) | 2004-06-03 | 2006-02-07 | Frid Noureddine | Luminal endoprosthesis FOR OBSTRUCTION OF ANEURYSM AND METHOD OF MANUFACTURING SUCH STENT. |
US9308382B2 (en) | 2004-06-10 | 2016-04-12 | Medtronic Urinary Solutions, Inc. | Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue |
US8048145B2 (en) | 2004-07-22 | 2011-11-01 | Endologix, Inc. | Graft systems having filling structures supported by scaffolds and methods for their use |
EP1827250B1 (en) | 2004-08-31 | 2018-05-16 | Cook Medical Technologies LLC | Device for treating an aneurysm |
US9655633B2 (en) | 2004-09-10 | 2017-05-23 | Penumbra, Inc. | System and method for treating ischemic stroke |
US7244270B2 (en) | 2004-09-16 | 2007-07-17 | Evera Medical | Systems and devices for soft tissue augmentation |
EP1788956B1 (en) | 2004-09-17 | 2011-11-09 | Codman & Shurtleff, Inc. | Vascular occlusion device with an embolic mesh ribbon |
WO2006034153A2 (en) | 2004-09-17 | 2006-03-30 | Cordis Neurovascular, Inc. | Thin film metallic devices for plugging aneurysms or vessels |
US20070270902A1 (en) | 2004-09-17 | 2007-11-22 | Slazas Robert R | Thin Film Metallic Devices for Plugging Aneurysms or Vessels |
EP1804719A2 (en) | 2004-09-22 | 2007-07-11 | Lee R. Guterman | Cranial aneurysm treatment arrangement |
US20060089637A1 (en) | 2004-10-14 | 2006-04-27 | Werneth Randell L | Ablation catheter |
JP2008519613A (en) | 2004-11-09 | 2008-06-12 | ボストン サイエンティフィック リミテッド | Vascular occlusion device with composite shaped proximal portion and smaller diameter distal |
US20060106421A1 (en) | 2004-11-16 | 2006-05-18 | Clifford Teoh | Expansible neck bridge |
US8562672B2 (en) | 2004-11-19 | 2013-10-22 | Medtronic, Inc. | Apparatus for treatment of cardiac valves and method of its manufacture |
US9545300B2 (en) | 2004-12-22 | 2017-01-17 | W. L. Gore & Associates, Inc. | Filament-wound implantable devices |
US20060155367A1 (en) | 2005-01-07 | 2006-07-13 | Hines Richard A | Micro-pleated stent assembly |
US20060155323A1 (en) | 2005-01-07 | 2006-07-13 | Porter Stephen C | Intra-aneurysm devices |
WO2006078988A2 (en) | 2005-01-21 | 2006-07-27 | Loubert Suddaby | Aneurysm repair method and apparatus |
US8025668B2 (en) | 2005-04-28 | 2011-09-27 | C. R. Bard, Inc. | Medical device removal system |
US7377932B2 (en) | 2005-06-02 | 2008-05-27 | Cordis Neurovascular, Inc. | Embolic coil delivery system with mechanical release mechanism |
US7985238B2 (en) | 2005-06-02 | 2011-07-26 | Codman & Shurtleff, Inc. | Embolic coil delivery system with spring wire release mechanism |
US9636115B2 (en) | 2005-06-14 | 2017-05-02 | Stryker Corporation | Vaso-occlusive delivery device with kink resistant, flexible distal end |
AU2006262447A1 (en) | 2005-06-20 | 2007-01-04 | Medtronic Ablation Frontiers Llc | Ablation catheter |
US8545530B2 (en) | 2005-10-19 | 2013-10-01 | Pulsar Vascular, Inc. | Implantable aneurysm closure systems and methods |
JP2009512515A (en) | 2005-10-19 | 2009-03-26 | パルサー バスキュラー インコーポレイテッド | Methods and systems for clipping within a vessel and repairing intraluminal and tissue defects. |
US8066036B2 (en) | 2005-11-17 | 2011-11-29 | Microvention, Inc. | Three-dimensional complex coil |
WO2007076480A2 (en) | 2005-12-23 | 2007-07-05 | Levy Elad I | Bifurcated aneurysm treatment arrangement |
US20070167876A1 (en) | 2006-01-17 | 2007-07-19 | Euteneuer Charles L | Occluding guidewire and methods |
US20070186933A1 (en) | 2006-01-17 | 2007-08-16 | Pulmonx | Systems and methods for delivering flow restrictive element to airway in lungs |
US7744652B2 (en) | 2006-01-23 | 2010-06-29 | Hesham Morsi | Aneurysm sealing device |
CN101049266B (en) | 2006-04-03 | 2010-11-17 | 孟坚 | Medical use obstruction appliance, and manufacturing method |
JP5171804B2 (en) | 2006-03-14 | 2013-03-27 | サーモピューティックス インコーポレイテッド | Aneurysm coil delivery system |
CN101431963A (en) | 2006-03-24 | 2009-05-13 | 比奥米瑞斯公司 | Self-expandable endovascular device for aneurysm occlusion |
US9757260B2 (en) | 2006-03-30 | 2017-09-12 | Medtronic Vascular, Inc. | Prosthesis with guide lumen |
US20070239206A1 (en) | 2006-03-31 | 2007-10-11 | Shelton Frederick E Iv | Suture with adhesive/sealant delivery mechanism |
US9615832B2 (en) | 2006-04-07 | 2017-04-11 | Penumbra, Inc. | Aneurysm occlusion system and method |
US20070288083A1 (en) | 2006-05-12 | 2007-12-13 | Hines Richard A | Exclusion Device and System For Delivery |
BRPI0711784B8 (en) | 2006-06-15 | 2021-06-22 | Microvention Inc | embolization device constructed of expandable polymer and its method of preparation |
US8062325B2 (en) | 2006-07-31 | 2011-11-22 | Codman & Shurtleff, Inc. | Implantable medical device detachment system and methods of using the same |
US20080097401A1 (en) | 2006-09-22 | 2008-04-24 | Trapp Benjamin M | Cerebral vasculature device |
DE102006050385A1 (en) | 2006-10-05 | 2008-04-10 | pfm Produkte für die Medizin AG | Implantable mechanism for use in human and/or animal body for e.g. closing atrium septum defect, has partial piece that is folded back on another partial piece from primary form into secondary form of carrying structure |
US20080103505A1 (en) | 2006-10-26 | 2008-05-01 | Hendrik Raoul Andre Fransen | Containment device for site-specific delivery of a therapeutic material and methods of use |
US8372114B2 (en) | 2006-11-13 | 2013-02-12 | Electroformed Stents, Inc. | Over-the-wire exclusion device and system for delivery |
EP2263605A1 (en) | 2006-11-20 | 2010-12-22 | SeptRx, Inc. | Device and method for preventing the undesired passage of emboli from a venous blood pool to an arterial blood pool |
WO2008074027A1 (en) | 2006-12-13 | 2008-06-19 | Biomerix Corporation | Aneurysm occlusion devices |
US11166703B2 (en) | 2007-01-23 | 2021-11-09 | Cvdevices, Llc | Devices, systems, and methods for atrial appendage occlusion using light cure |
ES2856081T3 (en) | 2007-04-16 | 2021-09-27 | Occlutech Holding Ag | Occlusor for the occlusion of an atrial appendage and its production procedure |
EP2444010B1 (en) | 2007-05-18 | 2017-03-01 | Stryker European Holdings I, LLC | Medical implant detachment systems |
JP2010527742A (en) | 2007-05-31 | 2010-08-19 | レックス メディカル リミテッド パートナーシップ | Left atrial appendage closure device |
WO2008151204A1 (en) | 2007-06-04 | 2008-12-11 | Sequent Medical Inc. | Methods and devices for treatment of vascular defects |
US8034061B2 (en) | 2007-07-12 | 2011-10-11 | Aga Medical Corporation | Percutaneous catheter directed intravascular occlusion devices |
US8361138B2 (en) | 2007-07-25 | 2013-01-29 | Aga Medical Corporation | Braided occlusion device having repeating expanded volume segments separated by articulation segments |
US8500773B2 (en) | 2007-08-01 | 2013-08-06 | Boston Scientific Scimed, Inc. | Spring detach joint for delivering a detachable implantable device |
EP2324775B1 (en) | 2007-08-02 | 2012-06-20 | Occlutech Holding AG | Method of producing a medical implantable device |
US20090082803A1 (en) | 2007-09-26 | 2009-03-26 | Aga Medical Corporation | Braided vascular devices having no end clamps |
US9414842B2 (en) | 2007-10-12 | 2016-08-16 | St. Jude Medical, Cardiology Division, Inc. | Multi-component vascular device |
US8066757B2 (en) | 2007-10-17 | 2011-11-29 | Mindframe, Inc. | Blood flow restoration and thrombus management methods |
CA2709379C (en) | 2007-12-21 | 2016-08-16 | Microvention, Inc. | Hydrogel filaments for biomedical uses |
US9259225B2 (en) | 2008-02-19 | 2016-02-16 | St. Jude Medical, Cardiology Division, Inc. | Medical devices for treating a target site and associated method |
US9138213B2 (en) | 2008-03-07 | 2015-09-22 | W.L. Gore & Associates, Inc. | Heart occlusion devices |
JP4719757B2 (en) | 2008-03-19 | 2011-07-06 | シスメックス株式会社 | Biological component analyzer, reaction cartridge of biological component analyzer, and extraction cartridge of biological component analyzer |
US8974518B2 (en) | 2008-03-25 | 2015-03-10 | Medtronic Vascular, Inc. | Eversible branch stent-graft and deployment method |
DE102008015781B4 (en) | 2008-03-26 | 2011-09-29 | Malte Neuss | Device for sealing defects in the vascular system |
DK2265193T3 (en) | 2008-04-21 | 2012-01-23 | Nfocus Neuromedical Inc | Embolic devices with braided ball and delivery systems |
WO2009135082A1 (en) | 2008-04-30 | 2009-11-05 | Medtronic, Inc. | Techniques for placing medical leads for electrical stimulation of nerve tissue |
US11464518B2 (en) | 2008-05-01 | 2022-10-11 | Aneuclose Llc | Proximal concave neck bridge with central lumen and distal net for occluding cerebral aneurysms |
JP2011519300A (en) | 2008-05-01 | 2011-07-07 | アニュクローズ エルエルシー | Aneurysm occlusion device |
US10716573B2 (en) | 2008-05-01 | 2020-07-21 | Aneuclose | Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm |
EP2279023B1 (en) | 2008-05-02 | 2020-12-02 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
US8454632B2 (en) | 2008-05-12 | 2013-06-04 | Xlumena, Inc. | Tissue anchor for securing tissue layers |
US8070694B2 (en) | 2008-07-14 | 2011-12-06 | Medtronic Vascular, Inc. | Fiber based medical devices and aspiration catheters |
US8333796B2 (en) | 2008-07-15 | 2012-12-18 | Penumbra, Inc. | Embolic coil implant system and implantation method |
US9232992B2 (en) | 2008-07-24 | 2016-01-12 | Aga Medical Corporation | Multi-layered medical device for treating a target site and associated method |
US9351715B2 (en) | 2008-07-24 | 2016-05-31 | St. Jude Medical, Cardiology Division, Inc. | Multi-layered medical device for treating a target site and associated method |
US8262692B2 (en) | 2008-09-05 | 2012-09-11 | Merlin Md Pte Ltd | Endovascular device |
US20100069948A1 (en) | 2008-09-12 | 2010-03-18 | Micrus Endovascular Corporation | Self-expandable aneurysm filling device, system and method of placement |
US8721714B2 (en) | 2008-09-17 | 2014-05-13 | Medtronic Corevalve Llc | Delivery system for deployment of medical devices |
US8992568B2 (en) | 2008-10-20 | 2015-03-31 | Neil Duggal | Systems and methods for cerebrospinal fluid repair |
US8523902B2 (en) | 2009-01-30 | 2013-09-03 | Kfx Medical Corporation | System and method for attaching soft tissue to bone |
CA2758509C (en) | 2009-04-15 | 2018-02-20 | Microvention, Inc. | Implant delivery system |
US8398671B2 (en) | 2009-04-16 | 2013-03-19 | Stryker Corporation | Electrical contact for occlusive device delivery system |
US20120071911A1 (en) | 2009-05-20 | 2012-03-22 | University Of Miami | Spherical helix embolic coils for the treatment of cerebral aneurysms |
US8758423B2 (en) | 2009-06-18 | 2014-06-24 | Graftcraft I Goteborg Ab | Device and method for treating ruptured aneurysms |
US20120010644A1 (en) | 2009-07-09 | 2012-01-12 | Sideris Eleftherios B | Method and apparatus for occluding a physiological opening |
EP2453940A2 (en) | 2009-07-13 | 2012-05-23 | Yissum Research Development Company of The Hebrew University of Jerusalem | Intraluminal polymeric devices for the treatment of aneurysms |
WO2011038017A1 (en) | 2009-09-22 | 2011-03-31 | Penumbra, Inc. | Manual actuation system for deployment of implant |
CA2778639A1 (en) | 2009-11-05 | 2011-05-12 | Sequent Medical Inc. | Multiple layer filamentary devices or treatment of vascular defects |
US20110202085A1 (en) | 2009-11-09 | 2011-08-18 | Siddharth Loganathan | Braid Ball Embolic Device Features |
US9814562B2 (en) | 2009-11-09 | 2017-11-14 | Covidien Lp | Interference-relief type delivery detachment systems |
US8226657B2 (en) | 2009-11-10 | 2012-07-24 | Carefusion 207, Inc. | Systems and methods for vertebral or other bone structure height restoration and stabilization |
US8734458B2 (en) | 2009-12-07 | 2014-05-27 | Globus Medical, Inc. | Methods and apparatus for treating vertebral fractures |
DE102009058132B4 (en) | 2009-12-12 | 2014-07-24 | Bentley Surgical Gmbh | Cylindrical occluder for sealing hollow cylindrical body vessels |
CN102188300B (en) | 2010-03-02 | 2014-05-28 | 上海微创医疗器械(集团)有限公司 | Aneurismal surgical device |
WO2011130081A1 (en) | 2010-04-14 | 2011-10-20 | Microvention, Inc. | Implant delivery device |
US8764811B2 (en) | 2010-04-20 | 2014-07-01 | Medtronic Vascular, Inc. | Controlled tip release stent graft delivery system and method |
EP2387951B1 (en) | 2010-05-23 | 2012-12-26 | Occlutech Holding AG | Braided medical device and manufacturing method therefore |
DK2585125T3 (en) | 2010-06-25 | 2014-12-08 | Fort Wayne Metals Res Prod | Biodegradable composite wire for medical devices |
US8876878B2 (en) | 2010-07-23 | 2014-11-04 | Medtronic, Inc. | Attachment mechanism for stent release |
BR112013005429A2 (en) | 2010-09-06 | 2016-06-07 | Nonwotecc Medical Gmbh | "device for closing openings or cavities in blood vessels" |
JP6087281B2 (en) | 2010-09-10 | 2017-03-01 | メディナ メディカル,インコーポレイテッド | Device and method for treating vascular abnormalities |
US8998947B2 (en) | 2010-09-10 | 2015-04-07 | Medina Medical, Inc. | Devices and methods for the treatment of vascular defects |
US20130066357A1 (en) | 2010-09-10 | 2013-03-14 | Maria Aboytes | Devices and methods for the treatment of vascular defects |
CN101933850B (en) | 2010-09-16 | 2012-07-18 | 先健科技(深圳)有限公司 | Stopper and manufacturing method thereof |
US8616040B2 (en) | 2010-09-17 | 2013-12-31 | Medtronic Vascular, Inc. | Method of forming a drug-eluting medical device |
DE102010053111B4 (en) | 2010-12-01 | 2012-10-25 | Acandis Gmbh & Co. Kg | Arrangement with a device for supplying a medical functional element |
KR20140004679A (en) | 2010-12-20 | 2014-01-13 | 마이크로벤션, 인코포레이티드 | Polymer stents and methods of manufacture |
US20120165732A1 (en) | 2010-12-23 | 2012-06-28 | Synthes Usa, Llc | Balloon catheter comprising a zero-profile tip |
CA2824284C (en) | 2011-01-17 | 2020-10-27 | Novita Therapeutics, Llc | Ballstent device and methods of use |
US11484318B2 (en) | 2011-01-17 | 2022-11-01 | Artio Medical, Inc. | Expandable body device and method of use |
US8647358B2 (en) | 2011-01-21 | 2014-02-11 | Obalon Therapeutics Inc. | Intragastric device |
DE102011011869A1 (en) | 2011-02-22 | 2012-08-23 | Phenox Gmbh | implant |
CA2828960A1 (en) | 2011-03-02 | 2012-09-07 | Joe Michael Eskridge | Endovascular closure system |
US20120283768A1 (en) | 2011-05-05 | 2012-11-08 | Sequent Medical Inc. | Method and apparatus for the treatment of large and giant vascular defects |
US9486604B2 (en) | 2011-05-12 | 2016-11-08 | Medtronic, Inc. | Packaging and preparation tray for a delivery system |
WO2012158668A1 (en) | 2011-05-17 | 2012-11-22 | Stryker Corporation | Method of fabricating an implantable medical device that includes one or more thin film polymer support layers |
EP3741314B1 (en) | 2011-05-23 | 2022-12-21 | Covidien LP | Retrieval systems |
WO2012166467A1 (en) | 2011-05-27 | 2012-12-06 | Stryker Corporation | Assembly for percutaneously inserting an implantable medical device, steering the device to a target location and deploying the device |
DE102011102955B4 (en) | 2011-05-31 | 2018-05-03 | Acandis Gmbh & Co. Kg | Medical implant for arranging a hollow body, in particular an aneurysm, and method for producing a medical implant |
EP2713905B1 (en) | 2011-06-03 | 2022-03-16 | Pulsar Vascular, Inc. | Systems for enclosing an anatomical opening, including shock absorbing aneurysm devices |
US8764787B2 (en) | 2011-06-17 | 2014-07-01 | Aga Medical Corporation | Occlusion device and associated deployment method |
US20120330341A1 (en) | 2011-06-22 | 2012-12-27 | Becking Frank P | Folded-Flat Aneurysm Embolization Devices |
WO2013016618A2 (en) | 2011-07-27 | 2013-01-31 | The Cleveland Clinic Foundation | Apparatus, system, and method for treating a regurgitant heart valve |
US9198668B2 (en) | 2011-08-04 | 2015-12-01 | Cook Medical Technologies Llc | Cerebral aneurysm closure device |
US20130035665A1 (en) | 2011-08-05 | 2013-02-07 | W. L. Gore & Associates, Inc. | Polymer-Based Occlusion Devices, Systems and Methods |
EP2567663A1 (en) | 2011-09-09 | 2013-03-13 | Occlutech Holding AG | A collapsible medical closing device, a method and a medical system for delivering an object |
US8734500B2 (en) | 2011-09-27 | 2014-05-27 | DePuy Synthes Products, LLC | Distal detachment mechanisms for vascular devices |
US9750565B2 (en) | 2011-09-30 | 2017-09-05 | Medtronic Advanced Energy Llc | Electrosurgical balloons |
US8261648B1 (en) | 2011-10-17 | 2012-09-11 | Sequent Medical Inc. | Braiding mechanism and methods of use |
US8993831B2 (en) | 2011-11-01 | 2015-03-31 | Arsenal Medical, Inc. | Foam and delivery system for treatment of postpartum hemorrhage |
US9579104B2 (en) | 2011-11-30 | 2017-02-28 | Covidien Lp | Positioning and detaching implants |
BR112014016789A8 (en) | 2012-01-06 | 2017-07-04 | Inceptus Medical LLC | expandable occlusion devices and methods of use |
CA3049059C (en) | 2012-01-17 | 2023-03-07 | Metactive Medical, Inc. | Expandable body device and method of use |
WO2013116860A1 (en) | 2012-02-02 | 2013-08-08 | Inceptus Medical LLC | Aneurysm graft devices and methods |
AU2013231845B2 (en) | 2012-03-16 | 2017-07-06 | Terumo Corporation | Stent and stent delivery device |
US9833625B2 (en) | 2012-03-26 | 2017-12-05 | Medtronic, Inc. | Implantable medical device delivery with inner and outer sheaths |
US9717421B2 (en) | 2012-03-26 | 2017-08-01 | Medtronic, Inc. | Implantable medical device delivery catheter with tether |
US9808255B2 (en) | 2012-03-30 | 2017-11-07 | DePuy Synthes Products, Inc. | Embolic coil detachment mechanism with flexible distal member, resistive electrical heating element and shape memory polymer element |
DE102012102844B4 (en) | 2012-04-02 | 2020-03-19 | Acandis Gmbh | Occlusion device for implantation within an aneurysm and arrangement with such an occlusion device |
US9242290B2 (en) | 2012-04-03 | 2016-01-26 | Medtronic Vascular, Inc. | Method and apparatus for creating formed elements used to make wound stents |
US20150133989A1 (en) | 2012-04-20 | 2015-05-14 | Inceptus Medical, Llc | Expandable occlusion devices and methods of use |
US9078659B2 (en) | 2012-04-23 | 2015-07-14 | Covidien Lp | Delivery system with hooks for resheathability |
US9700399B2 (en) | 2012-04-26 | 2017-07-11 | Medtronic Vascular, Inc. | Stopper to prevent graft material slippage in a closed web stent-graft |
US9549832B2 (en) | 2012-04-26 | 2017-01-24 | Medtronic Vascular, Inc. | Apparatus and methods for filling a drug eluting medical device via capillary action |
WO2013184595A1 (en) | 2012-06-04 | 2013-12-12 | Penumbra, Inc. | Aneurysm occlusion system and method |
US9149190B2 (en) | 2012-07-17 | 2015-10-06 | Stryker Corporation | Notification system of deviation from predefined conditions |
EP2882350B1 (en) | 2012-08-13 | 2019-09-25 | MicroVention, Inc. | Shaped removal device |
SG11201501184XA (en) | 2012-08-22 | 2015-05-28 | Phenox Gmbh | Implant |
US9504476B2 (en) | 2012-10-01 | 2016-11-29 | Microvention, Inc. | Catheter markers |
CA2887604C (en) | 2012-10-15 | 2021-05-18 | Microvention, Inc. | Liquid embolic compositions and uses thereof for treating vascular conditions |
US20140135811A1 (en) | 2012-11-13 | 2014-05-15 | Covidien Lp | Occlusive devices |
US10039536B2 (en) | 2012-11-16 | 2018-08-07 | W. L. Gore & Associates, Inc. | Implantable medical device deployment system |
US9539022B2 (en) | 2012-11-28 | 2017-01-10 | Microvention, Inc. | Matter conveyance system |
EP2928550B1 (en) | 2012-12-07 | 2023-06-07 | Medtronic, Inc. | Minimally invasive implantable neurostimulation system |
US10342546B2 (en) | 2013-01-14 | 2019-07-09 | Microvention, Inc. | Occlusive device |
US10716549B2 (en) | 2013-03-05 | 2020-07-21 | St. Jude Medical, Cardiology Division, Inc. | Medical device for treating a target site |
US10973523B2 (en) | 2013-03-08 | 2021-04-13 | Aga Medical Corporation | Medical device for treating a target site |
US9681861B2 (en) | 2013-03-11 | 2017-06-20 | St. Jude Medical, Cardiology Division, Inc. | Percutaneous catheter directed collapsible medical closure device |
US9539382B2 (en) | 2013-03-12 | 2017-01-10 | Medtronic, Inc. | Stepped catheters with flow restrictors and infusion systems using the same |
US9717502B2 (en) | 2013-03-14 | 2017-08-01 | Stryker Corporation | Vaso-occlusive device delivery system |
US9539011B2 (en) | 2013-03-14 | 2017-01-10 | Stryker Corporation | Vaso-occlusive device delivery system |
WO2014150824A1 (en) | 2013-03-14 | 2014-09-25 | Stryker Corporation | Vaso-occlusive device delivery system |
WO2014151123A1 (en) | 2013-03-15 | 2014-09-25 | Microvention, Inc. | Multi-component obstruction removal system and method |
CN105142545B (en) | 2013-03-15 | 2018-04-06 | 柯惠有限合伙公司 | Locking device |
US9398966B2 (en) | 2013-03-15 | 2016-07-26 | Medtronic Vascular, Inc. | Welded stent and stent delivery system |
EP3620203A1 (en) | 2013-03-15 | 2020-03-11 | Insera Therapeutics, Inc. | Vascular treatment devices |
EP2967806B1 (en) | 2013-03-15 | 2017-12-06 | Microvention, Inc. | Embolic protection device |
ES2717678T3 (en) | 2013-04-22 | 2019-06-24 | Stryker European Holdings I Llc | Procedure for loading drugs onto implant surfaces coated with hydroxyapatite |
US9445928B2 (en) | 2013-05-30 | 2016-09-20 | Medtronic Vascular, Inc. | Delivery system having a single handed deployment handle for a retractable outer sheath |
DE102013106031B4 (en) | 2013-06-11 | 2015-07-02 | Acandis Gmbh & Co. Kg | Medical implant and system with such an implant |
US9955976B2 (en) | 2013-08-16 | 2018-05-01 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
US9078658B2 (en) | 2013-08-16 | 2015-07-14 | Sequent Medical, Inc. | Filamentary devices for treatment of vascular defects |
CA2918098A1 (en) | 2013-08-20 | 2015-02-26 | Boston Scientific Scimed, Inc. | Braided hemostasis shaft for improved torsional response |
US10076399B2 (en) | 2013-09-13 | 2018-09-18 | Covidien Lp | Endovascular device engagement |
US9675782B2 (en) | 2013-10-10 | 2017-06-13 | Medtronic Vascular, Inc. | Catheter pull wire actuation mechanism |
US9955978B2 (en) | 2013-10-25 | 2018-05-01 | Medtronic Vascular, Inc. | Tissue compression device with multi-chamber bladder |
US9795400B2 (en) | 2013-11-13 | 2017-10-24 | Covidien Lp | Galvanically assisted attachment of medical devices to thrombus |
US9833604B2 (en) | 2013-12-20 | 2017-12-05 | Microvention, Inc. | Delivery adapter |
WO2015095806A2 (en) | 2013-12-20 | 2015-06-25 | Microvention, Inc. | Device delivery system |
US11154302B2 (en) | 2014-03-31 | 2021-10-26 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
US11076860B2 (en) | 2014-03-31 | 2021-08-03 | DePuy Synthes Products, Inc. | Aneurysm occlusion device |
WO2015157181A1 (en) | 2014-04-08 | 2015-10-15 | Stryker Corporation | Implant delivery system |
US9629635B2 (en) | 2014-04-14 | 2017-04-25 | Sequent Medical, Inc. | Devices for therapeutic vascular procedures |
WO2015160721A1 (en) | 2014-04-14 | 2015-10-22 | Sequent Medical Inc. | Devices for therapeutic vascular procedures |
JP6571760B2 (en) | 2014-04-30 | 2019-09-04 | シーラス エンドバスキュラー リミテッド | Occlusion device |
WO2015167997A1 (en) | 2014-04-30 | 2015-11-05 | Stryker Corporation | Implant delivery system and method of use |
PL3142586T3 (en) | 2014-05-14 | 2021-05-31 | President And Fellows Of Harvard College | Catheter device for transmitting and reflecting light |
US9060777B1 (en) | 2014-05-28 | 2015-06-23 | Tw Medical Technologies, Llc | Vaso-occlusive devices and methods of use |
WO2015184075A1 (en) | 2014-05-28 | 2015-12-03 | Stryker European Holdings I, Llc | Vaso-occlusive devices and methods of use |
CN105792879A (en) | 2014-06-04 | 2016-07-20 | 恩菲纽姆血管技术有限公司 | Low radial force vascular device and method of occlusion |
BR102014014407A2 (en) | 2014-06-12 | 2016-04-19 | Biocelere Agroindustrial Ltda | expression cassette to transform eukaryotic cell, genetically modified micro-organism with efficient xylose consumption, process for biofuel and biochemical production and biofuel and / or biochemical thus produced |
US8900304B1 (en) | 2014-06-17 | 2014-12-02 | Abdulrazzaq Alobaid | Kyphoplasty cement encapsulation balloon |
US9668898B2 (en) | 2014-07-24 | 2017-06-06 | Medtronic Vascular, Inc. | Stent delivery system having dynamic deployment and methods of manufacturing same |
US9770577B2 (en) | 2014-09-15 | 2017-09-26 | Medtronic Xomed, Inc. | Pressure relief for a catheter balloon device |
WO2016044647A2 (en) | 2014-09-17 | 2016-03-24 | Metactive Medical, Inc. | Expandable body device and method of use |
US9579484B2 (en) | 2014-09-19 | 2017-02-28 | Medtronic Vascular, Inc. | Sterile molded dispenser |
CN104605909A (en) | 2014-12-30 | 2015-05-13 | 先健科技(深圳)有限公司 | Plugging device, manufacturing method for plugging device and woven mesh pipe for manufacturing plugging device |
WO2016118420A1 (en) | 2015-01-20 | 2016-07-28 | Neurogami Medical, Inc. | Micrograft for the treatment of intracranial aneurysms and method for use |
US9692557B2 (en) | 2015-02-04 | 2017-06-27 | Stryker European Holdings I, Llc | Apparatus and methods for administering treatment within a bodily duct of a patient |
EP3261703A4 (en) | 2015-02-25 | 2018-10-24 | Galaxy Therapeutics, LLC | System for and method of treating aneurysms |
CN204683687U (en) | 2015-04-15 | 2015-10-07 | 中国人民解放军第二军医大学 | A kind of intracranial aneurysm neck reconstructing device |
CN104958087B (en) * | 2015-07-28 | 2018-09-25 | 杭州诺茂医疗科技有限公司 | A kind of occluder for left auricle |
US10154905B2 (en) | 2015-08-07 | 2018-12-18 | Medtronic Vascular, Inc. | System and method for deflecting a delivery catheter |
US10307168B2 (en) | 2015-08-07 | 2019-06-04 | Terumo Corporation | Complex coil and manufacturing techniques |
EP3334354B1 (en) | 2015-08-11 | 2021-03-03 | Terumo Corporation | System for implant delivery |
EP4327786A3 (en) | 2015-09-18 | 2024-05-01 | Terumo Corporation | Pushable implant delivery system |
WO2017049212A1 (en) | 2015-09-18 | 2017-03-23 | Microvention, Inc. | Vessel prosthesis |
WO2017049312A1 (en) | 2015-09-18 | 2017-03-23 | Microvention, Inc. | Releasable delivery system |
CN108348323B (en) | 2015-09-18 | 2021-11-16 | 微仙美国有限公司 | Implant retention, detachment and delivery system |
CN108024821B (en) | 2015-09-21 | 2020-10-30 | 斯瑞克公司 | Embolectomy device |
WO2017053271A1 (en) | 2015-09-21 | 2017-03-30 | Stryker Corporation | Embolectomy devices |
US10172632B2 (en) | 2015-09-22 | 2019-01-08 | Medtronic Vascular, Inc. | Occlusion bypassing apparatus with a re-entry needle and a stabilization tube |
US10314593B2 (en) | 2015-09-23 | 2019-06-11 | Covidien Lp | Occlusive devices |
US10478194B2 (en) | 2015-09-23 | 2019-11-19 | Covidien Lp | Occlusive devices |
WO2017062383A1 (en) | 2015-10-07 | 2017-04-13 | Stryker Corporation | Multiple barrel clot removal devices |
US10327791B2 (en) | 2015-10-07 | 2019-06-25 | Medtronic Vascular, Inc. | Occlusion bypassing apparatus with a re-entry needle and a distal stabilization balloon |
US10786302B2 (en) | 2015-10-09 | 2020-09-29 | Medtronic, Inc. | Method for closure and ablation of atrial appendage |
US10271873B2 (en) | 2015-10-26 | 2019-04-30 | Medtronic Vascular, Inc. | Sheathless guide catheter assembly |
US20170147765A1 (en) | 2015-11-19 | 2017-05-25 | Penumbra, Inc. | Systems and methods for treatment of stroke |
US10631946B2 (en) | 2015-11-30 | 2020-04-28 | Penumbra, Inc. | System for endoscopic intracranial procedures |
EP3386580B1 (en) | 2015-12-09 | 2023-11-01 | Medtronic Vascular Inc. | Catheter with a lumen shaped as an identification symbol |
US10500046B2 (en) | 2015-12-14 | 2019-12-10 | Medtronic, Inc. | Delivery system having retractable wires as a coupling mechanism and a deployment mechanism for a self-expanding prosthesis |
US10159568B2 (en) | 2015-12-14 | 2018-12-25 | Medtronic, Inc. | Delivery system having retractable wires as a coupling mechanism and a deployment mechanism for a self-expanding prosthesis |
CN114732470A (en) | 2015-12-30 | 2022-07-12 | 斯瑞克公司 | Embolization device and method of making same |
US20170189033A1 (en) | 2016-01-06 | 2017-07-06 | Microvention, Inc. | Occlusive Embolic Coil |
US10070950B2 (en) | 2016-02-09 | 2018-09-11 | Medtronic Vascular, Inc. | Endoluminal prosthetic assemblies, and associated systems and methods for percutaneous repair of a vascular tissue defect |
CN109219407B (en) | 2016-02-10 | 2022-05-13 | 微仙美国有限公司 | Device for vascular occlusion |
CA3014315C (en) | 2016-02-10 | 2022-03-01 | Microvention, Inc. | Intravascular treatment site access |
US10188500B2 (en) | 2016-02-12 | 2019-01-29 | Medtronic Vascular, Inc. | Stent graft with external scaffolding and method |
CN108697423A (en) | 2016-02-16 | 2018-10-23 | 伊瑟拉医疗公司 | The part flow arrangement of suction unit and anchoring |
US10952739B2 (en) | 2016-03-11 | 2021-03-23 | Sequent Medical, Inc. | Systems and methods for delivery of stents and stent-like devices |
CN109069160B (en) | 2016-03-17 | 2022-05-17 | S·珍耶那曼 | Occlusion of anatomical structures |
EP3436124B1 (en) | 2016-03-31 | 2022-08-31 | Medtronic Vascular Inc. | Expandable introducer sheath having a steering mechanism |
US20170281331A1 (en) | 2016-03-31 | 2017-10-05 | Medtronic Vascular, Inc. | Endoluminal prosthetic devices having fluid-absorbable compositions for repair of a vascular tissue defect |
US10695542B2 (en) | 2016-04-04 | 2020-06-30 | Medtronic Vascular, Inc. | Drug coated balloon |
US10252024B2 (en) | 2016-04-05 | 2019-04-09 | Stryker Corporation | Medical devices and methods of manufacturing same |
US10441407B2 (en) | 2016-04-12 | 2019-10-15 | Medtronic Vascular, Inc. | Gutter filling stent-graft and method |
US9987122B2 (en) | 2016-04-13 | 2018-06-05 | Medtronic Vascular, Inc. | Iliac branch device and method |
US10010403B2 (en) | 2016-04-18 | 2018-07-03 | Medtronic Vascular, Inc. | Stent-graft prosthesis and method of manufacture |
US20170304097A1 (en) | 2016-04-21 | 2017-10-26 | Medtronic Vascular, Inc. | Stent-graft delivery system having an inner shaft component with a loading pad or covering on a distal segment thereof for stent retention |
ES2809160T3 (en) | 2016-04-25 | 2021-03-03 | Stryker Corp | Inversion mechanical thrombectomy appliance |
US10940294B2 (en) | 2016-04-25 | 2021-03-09 | Medtronic Vascular, Inc. | Balloon catheter including a drug delivery sheath |
CN109310446B (en) | 2016-04-25 | 2021-08-27 | 斯瑞克公司 | Preloaded eversion retractor thrombectomy devices and methods |
US10028759B2 (en) | 2016-04-25 | 2018-07-24 | Stryker Corporation | Anti-jamming and macerating thrombectomy apparatuses and methods |
US10517711B2 (en) | 2016-04-25 | 2019-12-31 | Medtronic Vascular, Inc. | Dissection prosthesis system and method |
US10406011B2 (en) | 2016-04-28 | 2019-09-10 | Medtronic Vascular, Inc. | Implantable medical device delivery system |
US10191615B2 (en) | 2016-04-28 | 2019-01-29 | Medtronic Navigation, Inc. | Method and apparatus for image-based navigation |
US11147952B2 (en) | 2016-04-28 | 2021-10-19 | Medtronic Vascular, Inc. | Drug coated inflatable balloon having a thermal dependent release layer |
US10292844B2 (en) | 2016-05-17 | 2019-05-21 | Medtronic Vascular, Inc. | Method for compressing a stented prosthesis |
JP6803929B2 (en) | 2016-06-01 | 2020-12-23 | マイクロベンション インコーポレイテッドMicrovention, Inc. | Improved reinforced balloon catheter |
EP4094699A1 (en) | 2016-06-03 | 2022-11-30 | Stryker Corporation | Inverting thrombectomy apparatuses |
US20200000477A1 (en) | 2016-08-03 | 2020-01-02 | Henry Nita LLC | Embolization Plug |
US20190209178A1 (en) | 2016-09-14 | 2019-07-11 | Medinol Ltd. | Aneurysm closure device |
JP7139346B2 (en) | 2017-02-23 | 2022-09-20 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | Aneurysm device and delivery system |
US20180303531A1 (en) | 2017-04-24 | 2018-10-25 | Baxter International Inc. | Single-handed applicator |
WO2018218210A1 (en) | 2017-05-25 | 2018-11-29 | Microvention, Inc. | Adhesive occlusion systems |
CN107374688A (en) | 2017-07-17 | 2017-11-24 | 湖南瑞康通科技发展有限公司 | Plugging device in a kind of tube chamber |
WO2019038293A1 (en) | 2017-08-21 | 2019-02-28 | Cerus Endovascular Limited | Occlusion device |
US10806462B2 (en) | 2017-12-21 | 2020-10-20 | DePuy Synthes Products, Inc. | Implantable medical device detachment system with split tube and cylindrical coupling |
US10751065B2 (en) | 2017-12-22 | 2020-08-25 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10716574B2 (en) | 2017-12-22 | 2020-07-21 | DePuy Synthes Products, Inc. | Aneurysm device and delivery method |
US11103252B2 (en) | 2018-01-23 | 2021-08-31 | Swaminathan Jayaraman | Device to treat vascular defect and method of making the same |
US10905430B2 (en) | 2018-01-24 | 2021-02-02 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10806461B2 (en) | 2018-04-27 | 2020-10-20 | DePuy Synthes Products, Inc. | Implantable medical device detachment system with split tube |
US11058430B2 (en) | 2018-05-25 | 2021-07-13 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US11596412B2 (en) | 2018-05-25 | 2023-03-07 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US10939915B2 (en) | 2018-05-31 | 2021-03-09 | DePuy Synthes Products, Inc. | Aneurysm device and delivery system |
US11076861B2 (en) | 2018-10-12 | 2021-08-03 | DePuy Synthes Products, Inc. | Folded aneurysm treatment device and delivery method |
US10653425B1 (en) | 2019-05-21 | 2020-05-19 | DePuy Synthes Products, Inc. | Layered braided aneurysm treatment device |
-
2020
- 2020-05-01 US US16/865,165 patent/US11672542B2/en active Active
-
2023
- 2023-01-26 US US18/101,630 patent/US20230172614A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11672542B2 (en) | 2023-06-13 |
US20200367906A1 (en) | 2020-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11672542B2 (en) | Aneurysm treatment with pushable ball segment | |
US11583282B2 (en) | Layered braided aneurysm treatment device | |
US11633191B2 (en) | Folded aneurysm treatment device and delivery method | |
JP7139346B2 (en) | Aneurysm device and delivery system | |
US11547414B2 (en) | Spiral delivery system for embolic braid | |
US20220225997A1 (en) | Aneurysm treatment device | |
US20220323082A1 (en) | Layered braided aneurysm treatment device | |
US11607226B2 (en) | Layered braided aneurysm treatment device with corrugations | |
EP3718491A2 (en) | Aneurysm treatment device | |
EP3906863A2 (en) | Double layer braid for occlusion of aneurysms | |
EP3741313A1 (en) | Layered braided aneurysm treatment device | |
US11497504B2 (en) | Aneurysm treatment with pushable implanted braid | |
US20230016312A1 (en) | Aneurysm treatment with pushable implanted braid | |
US20220087681A1 (en) | Inverting braided aneurysm implant with dome feature | |
EP3854320A1 (en) | Layered braided aneurysm treatment device | |
US20240099720A1 (en) | Braided implant with detachment mechanism | |
US20240108354A1 (en) | Braided implant with integrated embolic coil |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: DEPUY SYNTHES PRODUCTS, INC., MASSACHUSETTS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:XU, RUIJIAO;GOROCHOW, LACEY;SIGNING DATES FROM 20200429 TO 20200430;REEL/FRAME:062494/0637 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |